TreeWAS – Variant ID: rs2853926

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Click here to show this figure without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
K90.0 Coeliac disease	0.000	0.000	1.000
L40.9 Psoriasis, unspecified	1.000	0.000	0.000
L40.5 Arthropathic psoriasis	1.000	0.000	0.000
L40 Psoriasis	1.000	0.000	0.000
E10 Insulin-dependent diabetes mellitus	0.000	0.000	1.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.000	1.000
E10-E14 Diabetes mellitus	0.000	0.000	1.000
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.000	1.000
E00-E07 Disorders of thyroid gland	0.000	0.000	1.000
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.001	0.999
L40.0 Psoriasis vulgaris	0.998	0.002	0.000
E10.3 With ophthalmic complications	0.000	0.010	0.990
E05.9 Thyrotoxicosis, unspecified	0.000	0.013	0.987
E03.9 Hypothyroidism, unspecified	0.986	0.014	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.016	0.984
E65-E68 Obesity and other hyperalimentation	0.000	0.023	0.977
E16 Other disorders of pancreatic internal secretion	0.000	0.027	0.973
M35 Other systemic involvement of connective tissue	0.000	0.029	0.971
E10.2 With renal complications	0.000	0.030	0.970
E10.9 Without complications	0.000	0.032	0.968
M20-M25 Other joint disorders	0.000	0.033	0.967
M35.3 Polymyalgia rheumatica	0.000	0.034	0.966
M25 Other joint disorders, not elsewhere classified	0.000	0.035	0.965
M25.5 Pain in joint	0.000	0.035	0.965
E16.2 Hypoglycaemia, unspecified	0.000	0.037	0.963
M35.0 Sicca syndrome [Sjogren]	0.000	0.039	0.961
M25.51 Pain in joint (Shoulder region)	0.000	0.046	0.954
E66 Obesity	0.000	0.046	0.954
E66.8 Other obesity	0.000	0.058	0.942
M34 Systemic sclerosis	0.000	0.071	0.929
M21 Other acquired deformities of limbs	0.000	0.081	0.919
M25.55 Pain in joint (Pelvic region and thigh)	0.000	0.087	0.913
M25.9 Joint disorder, unspecified	0.000	0.092	0.908
E10.1 With ketoacidosis	0.000	0.104	0.896
M25.54 Pain in joint (Hand)	0.000	0.105	0.895
E10.4 With neurological complications	0.000	0.119	0.881
M21.1 Varus deformity, not elsewhere classified	0.000	0.132	0.868
M34.9 Systemic sclerosis, unspecified	0.000	0.134	0.866
L40.8 Other psoriasis	0.862	0.138	0.000
E03 Other hypothyroidism	0.761	0.148	0.091
M25.96 Joint disorder, unspecified (Lower leg)	0.000	0.149	0.851
M21.16 Varus deformity, not elsewhere classified (Lower leg)	0.000	0.151	0.849
M21.0 Valgus deformity, not elsewhere classified	0.000	0.154	0.846
E16.0 Drug-induced hypoglycaemia without coma	0.000	0.168	0.832
L40.1 Generalised pustular psoriasis	0.829	0.171	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.000	0.181	0.819
M34.8 Other forms of systemic sclerosis	0.000	0.189	0.811
M21.06 Valgus deformity, not elsewhere classified (Lower leg)	0.000	0.197	0.803
M25.58 Pain in joint (Other)	0.000	0.198	0.802
E14 Unspecified diabetes mellitus	0.000	0.200	0.800
M25.52 Pain in joint (Upper arm)	0.000	0.201	0.799
E10.8 With unspecified complications	0.000	0.206	0.794
E66.0 Obesity due to excess calories	0.000	0.207	0.793
E06 Thyroiditis	0.000	0.212	0.788
E65 Localised adiposity	0.000	0.218	0.782
M25.59 Pain in joint (Site unspecified)	0.000	0.218	0.782
E50-E64 Other nutritional deficiencies	0.000	0.220	0.780
E66.2 Extreme obesity with alveolar hypoventilation	0.000	0.223	0.777
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.000	0.226	0.774
M32 Systemic lupus erythematosus	0.000	0.240	0.760
E10.6 With other specified complications	0.000	0.242	0.758
E10.0 With coma	0.000	0.246	0.754
M35.2 Behcet's disease	0.000	0.250	0.750
M25.0 Haemarthrosis	0.000	0.256	0.744
L40.4 Guttate psoriasis	0.742	0.258	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.262	0.738
M31 Other necrotising vasculopathies	0.000	0.266	0.734
M30 Polyarteritis nodosa and related conditions	0.000	0.268	0.732
E14.3 With ophthalmic complications	0.000	0.269	0.731
M25.94 Joint disorder, unspecified (Hand)	0.000	0.275	0.725
M21.7 Unequal limb length (acquired)	0.000	0.282	0.718
L40.3 Pustulosis palmaris et plantaris	0.717	0.283	0.000
L40.2 Acrodermatitis continua	0.717	0.283	0.000
E10.7 With multiple complications	0.000	0.283	0.717
E12 Malnutrition-related diabetes mellitus	0.000	0.283	0.717
E05.8 Other thyrotoxicosis	0.000	0.283	0.717
E05.5 Thyroid crisis or storm	0.000	0.283	0.717
E05.4 Thyrotoxicosis factitia	0.000	0.283	0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.283	0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.283	0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.283	0.717
E00 Congenital iodine-deficiency syndrome	0.000	0.283	0.717
E15 Nondiabetic hypoglycaemic coma	0.000	0.294	0.705
M21.4 Flat foot [pes planus] (acquired)	0.000	0.296	0.704
E67 Other hyperalimentation	0.000	0.299	0.700
E68 Sequelae of hyperalimentation	0.000	0.299	0.700
E16.9 Disorder of pancreatic internal secretion, unspecified	0.000	0.303	0.697
E16.8 Other specified disorders of pancreatic internal secretion	0.000	0.303	0.697
E16.4 Abnormal secretion of gastrin	0.000	0.303	0.697
E16.3 Increased secretion of glucagon	0.000	0.303	0.697
M35.9 Systemic involvement of connective tissue, unspecified	0.000	0.304	0.696
M35.6 Relapsing panniculitis [Weber-Christian]	0.000	0.304	0.696
M35.5 Multifocal fibrosclerosis	0.000	0.304	0.696
M35.4 Diffuse (eosinophilic) fasciitis	0.000	0.304	0.696
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.000	0.307	0.693
M25.2 Flail joint	0.000	0.308	0.692
M25.1 Fistula of joint	0.000	0.308	0.692
M25.97 Joint disorder, unspecified (Ankle and foot)	0.000	0.310	0.690
E06.9 Thyroiditis, unspecified	0.000	0.311	0.689
E10.5 With peripheral circulatory complications	0.000	0.315	0.685
E66.1 Drug-induced obesity	0.000	0.316	0.684
M35.7 Hypermobility syndrome	0.000	0.317	0.683
M34.1 CR(E)ST syndrome	0.000	0.320	0.680
M25.53 Pain in joint (Forearm)	0.000	0.322	0.678
M35.8 Other specified systemic involvement of connective tissue	0.000	0.326	0.674
M25.95 Joint disorder, unspecified (Pelvic region and thigh)	0.000	0.331	0.668
M25.56 Pain in joint (Lower leg)	0.000	0.332	0.668
M34.2 Systemic sclerosis induced by drugs and chemicals	0.000	0.334	0.666
M34.0 Progressive systemic sclerosis	0.000	0.334	0.666
M25.8 Other specified joint disorders	0.000	0.337	0.663
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.000	0.344	0.656
M21.8 Other specified acquired deformities of limbs	0.000	0.346	0.654
E03.8 Other specified hypothyroidism	0.610	0.347	0.043
M25.99 Joint disorder, unspecified (Site unspecified)	0.000	0.349	0.651
M25.98 Joint disorder, unspecified (Other)	0.000	0.349	0.651
M25.92 Joint disorder, unspecified (Upper arm)	0.000	0.349	0.651
M25.90 Joint disorder, unspecified (Multiple sites)	0.000	0.349	0.651
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.000	0.349	0.651
M32.1 Systemic lupus erythematosus with organ or system involvement	0.000	0.350	0.650
M35.1 Other overlap syndromes	0.000	0.351	0.648
M21.9 Acquired deformity of limb, unspecified	0.000	0.351	0.648
E14.8 With unspecified complications	0.000	0.353	0.647
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.590	0.358	0.052
E03.0 Congenital hypothyroidism with diffuse goitre	0.579	0.362	0.059
M21.3 Wrist or foot drop (acquired)	0.000	0.364	0.636
M21.6 Other acquired deformities of ankle and foot	0.000	0.367	0.633
M25.93 Joint disorder, unspecified (Forearm)	0.000	0.371	0.629
M31.6 Other giant cell arteritis	0.000	0.377	0.623
E13 Other specified diabetes mellitus	0.000	0.377	0.622
M21.19 Varus deformity, not elsewhere classified (Site unspecified)	0.000	0.378	0.622
M21.18 Varus deformity, not elsewhere classified (Other)	0.000	0.378	0.622
M21.15 Varus deformity, not elsewhere classified (Pelvic region and thigh)	0.000	0.378	0.622
M21.14 Varus deformity, not elsewhere classified (Hand)	0.000	0.378	0.622
M21.13 Varus deformity, not elsewhere classified (Forearm)	0.000	0.378	0.622
M21.12 Varus deformity, not elsewhere classified (Upper arm)	0.000	0.378	0.622
M21.11 Varus deformity, not elsewhere classified (Shoulder region)	0.000	0.378	0.622
M21.10 Varus deformity, not elsewhere classified (Multiple sites)	0.000	0.378	0.622
E11 Non-insulin-dependent diabetes mellitus	0.000	0.380	0.620
J47 Bronchiectasis	0.000	0.381	0.619
E03.1 Congenital hypothyroidism without goitre	0.555	0.383	0.061
E14.1 With ketoacidosis	0.000	0.383	0.617
M25.91 Joint disorder, unspecified (Shoulder region)	0.000	0.386	0.613
E04 Other non-toxic goitre	0.000	0.388	0.612
E07 Other disorders of thyroid	0.000	0.388	0.612
E03.5 Myxoedema coma	0.546	0.389	0.065
E03.4 Atrophy of thyroid (acquired)	0.546	0.389	0.065
E03.3 Postinfectious hypothyroidism	0.546	0.389	0.065
M24 Other specific joint derangements	0.000	0.390	0.610
M21.09 Valgus deformity, not elsewhere classified (Site unspecified)	0.000	0.393	0.606
M21.08 Valgus deformity, not elsewhere classified (Other)	0.000	0.393	0.606
M21.05 Valgus deformity, not elsewhere classified (Pelvic region and thigh)	0.000	0.393	0.606
M21.04 Valgus deformity, not elsewhere classified (Hand)	0.000	0.393	0.606
M21.03 Valgus deformity, not elsewhere classified (Forearm)	0.000	0.393	0.606
M21.02 Valgus deformity, not elsewhere classified (Upper arm)	0.000	0.393	0.606
M21.01 Valgus deformity, not elsewhere classified (Shoulder region)	0.000	0.393	0.606
M21.00 Valgus deformity, not elsewhere classified (Multiple sites)	0.000	0.393	0.606
E55 Vitamin D deficiency	0.000	0.395	0.605
M21.75 Unequal limb length (acquired) (Pelvic region and thigh)	0.000	0.397	0.603
E14.6 With other specified complications	0.000	0.405	0.595
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.000	0.409	0.591
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.000	0.412	0.587
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.000	0.412	0.587
E40-E46 Malnutrition	0.000	0.413	0.587
M25.06 Haemarthrosis (Lower leg)	0.000	0.414	0.586
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.000	0.420	0.580
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.000	0.422	0.578
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.000	0.423	0.576
E58 Dietary calcium deficiency	0.000	0.424	0.576
E14.7 With multiple complications	0.000	0.426	0.574
E14.2 Withrenal complications	0.000	0.426	0.574
E14.0 With coma	0.000	0.426	0.574
E53 Deficiency of other B group vitamins	0.000	0.430	0.570
M25.3 Other instability of joint	0.000	0.430	0.570
M24.1 Other articular cartilage disorders	0.000	0.430	0.570
E04.9 Non-toxic goitre, unspecified	0.000	0.431	0.569
E06.4 Drug-induced thyroiditis	0.000	0.435	0.565
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.000	0.435	0.565
E06.1 Subacute thyroiditis	0.000	0.435	0.565
E06.0 Acute thyroiditis	0.000	0.435	0.565
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.000	0.435	0.565
M25.84 Other specified joint disorders (Hand)	0.000	0.441	0.559
E64 Sequelae of malnutrition and other nutritional deficiencies	0.000	0.441	0.559
E63 Other nutritional deficiencies	0.000	0.441	0.559
E51 Thiamine deficiency	0.000	0.441	0.559
E50 Vitamin A deficiency	0.000	0.441	0.559
E60 Dietary zinc deficiency	0.000	0.441	0.559
E59 Dietary selenium deficiency	0.000	0.441	0.559
E54 Ascorbic acid deficiency	0.000	0.441	0.559
E52 Niacin deficiency [pellagra]	0.000	0.441	0.559
E14.5 With peripheral circulatory complications	0.000	0.443	0.557
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.000	0.443	0.557
E61 Deficiency of other nutrient elements	0.000	0.443	0.556
E06.3 Autoimmune thyroiditis	0.000	0.444	0.556
E56 Other vitamin deficiencies	0.000	0.444	0.556
M31.1 Thrombotic microangiopathy	0.000	0.449	0.551
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.000	0.450	0.550
M21.47 Flat foot [pes planus] (acquired)-Ankle/foot	0.000	0.450	0.550
M32.9 Systemic lupus erythematosus, unspecified	0.000	0.455	0.545
M32.0 Drug-induced systemic lupus erythematosus	0.000	0.455	0.545
M25.81 Other specified joint disorders (Shoulder region)	0.000	0.457	0.543
E11.5 With peripheral circulatory complications	0.000	0.460	0.540
E16.1 Other hypoglycaemia	0.000	0.462	0.538
E11.8 With unspecified complications	0.000	0.466	0.534
M25.09 Haemarthrosis (Site unspecified)	0.000	0.466	0.534
M25.08 Haemarthrosis (Other)	0.000	0.466	0.534
M25.07 Haemarthrosis (Ankle and foot)	0.000	0.466	0.534
M25.05 Haemarthrosis (Pelvic region and thigh)	0.000	0.466	0.534
M25.04 Haemarthrosis (Hand)	0.000	0.466	0.534
M25.03 Haemarthrosis (Forearm)	0.000	0.466	0.534
M25.02 Haemarthrosis (Upper arm)	0.000	0.466	0.534
M25.01 Haemarthrosis (Shoulder region)	0.000	0.466	0.534
M25.00 Haemarthrosis (Multiple sites)	0.000	0.466	0.534
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.000	0.469	0.530
M31.8 Other specified necrotising vasculopathies	0.000	0.473	0.527
M31.4 Aortic arch syndrome [Takayasu]	0.000	0.473	0.527
M31.2 Lethal midline granuloma	0.000	0.473	0.527
M25.87 Other specified joint disorders (Ankle and foot)	0.000	0.474	0.526
M30.8 Other conditions related to polyarteritis nodosa	0.000	0.475	0.525
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.000	0.475	0.525
M30.2 Juvenile polyarteritis	0.000	0.475	0.525
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.000	0.478	0.522
M24.16 Other articular cartilage disorders (Lower leg)	0.000	0.483	0.517
M21.79 Unequal limb length (acquired) (Site unspecified)	0.000	0.485	0.515
M21.78 Unequal limb length (acquired)-Other	0.000	0.485	0.515
M21.77 Unequal limb length (acquired) (Ankle and foot)	0.000	0.485	0.515
M21.74 Unequal limb length (acquired) (Hand)	0.000	0.485	0.515
M21.73 Unequal limb length (acquired) (Forearm)	0.000	0.485	0.515
M21.72 Unequal limb length (acquired) (Upper arm)	0.000	0.485	0.515
M21.71 Unequal limb length (acquired)-Shldr region	0.000	0.485	0.515
M21.70 Unequal limb length (acquired) (Multiple sites)	0.000	0.485	0.515
M31.0 Hypersensitivity angiitis	0.000	0.486	0.514
E12.9 Without complications	0.000	0.486	0.514
E12.8 With unspecified complications	0.000	0.486	0.514
E12.7 With multiple complications	0.000	0.486	0.514
E12.6 With other specified complications	0.000	0.486	0.514
E12.5 With peripheral circulatory complications	0.000	0.486	0.514
E12.4 With neurological complications	0.000	0.486	0.514
E12.3 With ophthalmic complications	0.000	0.486	0.514
E12.2 With renal complications	0.000	0.486	0.514
E12.1 With ketoacidosis	0.000	0.486	0.514
E12.0 With coma	0.000	0.486	0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.000	0.486	0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.000	0.486	0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.000	0.486	0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.000	0.486	0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.486	0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.000	0.486	0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.000	0.486	0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.000	0.486	0.514
M25.86 Other specified joint disorders (Lower leg)	0.000	0.489	0.511
E11.3 With ophthalmic complications	0.000	0.494	0.506
M21.49 Flat foot [pes planus] (acquired)-Site unspec	0.000	0.495	0.505
M21.48 Flat foot [pes planus] (acquired)-Other	0.000	0.495	0.505
M21.46 Flat foot [pes planus] (acquired)-Lower leg	0.000	0.495	0.505
M21.45 Flat foot [pes planus] (acquired)-Pelvic/thigh	0.000	0.495	0.505
M21.44 Flat foot [pes planus] (acquired)-Hand	0.000	0.495	0.505
M21.43 Flat foot [pes planus] (acquired)-Forearm	0.000	0.495	0.505
M21.42 Flat foot [pes planus] (acquired)-Upper arm	0.000	0.495	0.505
M21.41 Flat foot [pes planus] (acquired)-Shldr region	0.000	0.495	0.505
M21.40 Flat foot [pes planus] (acquired)-Mult sites	0.000	0.495	0.505
M30.0 Polyarteritis nodosa	0.000	0.495	0.505
E67.8 Other specified hyperalimentation	0.000	0.498	0.502
E67.3 Hypervitaminosis D	0.000	0.498	0.502
E67.2 Megavitamin-B6 syndrome	0.000	0.498	0.502
E67.1 Hypercarotenaemia	0.000	0.498	0.502
E67.0 Hypervitaminosis A	0.000	0.498	0.502
M24.0 Loose body in joint	0.000	0.498	0.502
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified	0.000	0.501	0.499
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.000	0.503	0.497
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.000	0.503	0.497
M36.3 Arthropathy in other blood disorders	0.000	0.503	0.497
M36.2 Haemophilic arthropathy	0.000	0.503	0.497
M36.1 Arthropathy in neoplastic disease	0.000	0.503	0.497
M36.0 Dermato(poly)myositis in neoplastic disease	0.000	0.503	0.497
M25.19 Fistula of joint (Site unspecified)	0.000	0.504	0.496
M25.18 Fistula of joint (Other)	0.000	0.504	0.496
M25.17 Fistula of joint (Ankle and foot)	0.000	0.504	0.496
M25.16 Fistula of joint (Lower leg)	0.000	0.504	0.496
M25.15 Fistula of joint (Pelvic region and thigh)	0.000	0.504	0.496
M25.14 Fistula of joint (Hand)	0.000	0.504	0.496
M25.13 Fistula of joint (Forearm)	0.000	0.504	0.496
M25.12 Fistula of joint (Upper arm)	0.000	0.504	0.496
M25.11 Fistula of joint (Shoulder region)	0.000	0.504	0.496
M25.10 Fistula of joint (Multiple sites)	0.000	0.504	0.496
M25.29 Flail joint (Site unspecified)	0.000	0.504	0.496
M25.28 Flail joint (Other)	0.000	0.504	0.496
M25.27 Flail joint (Ankle and foot)	0.000	0.504	0.496
M25.26 Flail joint (Lower leg)	0.000	0.504	0.496
M25.25 Flail joint (Pelvic region and thigh)	0.000	0.504	0.496
M25.24 Flail joint (Hand)	0.000	0.504	0.496
M25.23 Flail joint (Forearm)	0.000	0.504	0.496
M25.22 Flail joint (Upper arm)	0.000	0.504	0.496
M25.21 Flail joint (Shoulder region)	0.000	0.504	0.496
M25.20 Flail joint (Multiple sites)	0.000	0.504	0.496
M31.9 Necrotising vasculopathy, unspecified	0.000	0.509	0.491
K90 Intestinal malabsorption	0.000	0.509	0.491
M07.39 Other psoriatic arthropathies (Site unspecified)	0.488	0.512	0.000
E14.4 With neurological complications	0.000	0.520	0.480
E55.9 Vitamin D deficiency, unspecified	0.000	0.520	0.480
E53.9 Vitamin B deficiency, unspecified	0.000	0.520	0.480
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.000	0.523	0.477
M25.89 Other specified joint disorders (Site unspecified)	0.000	0.524	0.476
M25.82 Other specified joint disorders (Upper arm)	0.000	0.524	0.476
M25.80 Other specified joint disorders (Multiple sites)	0.000	0.524	0.476
M21.37 Wrist or foot drop (acquired) (Ankle and foot)	0.000	0.528	0.472
M32.8 Other forms of systemic lupus erythematosus	0.000	0.529	0.471
M21.89 Other specified acquired deformities of limbs (Site unspecified)	0.000	0.531	0.469
M21.88 Other specified acquired deformities of limbs-Other	0.000	0.531	0.469
M21.87 Other specified acquired deformities of limbs (Ankle and foot)	0.000	0.531	0.469
M21.86 Other specified acquired deformities of limbs (Lower leg)	0.000	0.531	0.469
M21.84 Other specified acquired deformities of limbs (Hand)	0.000	0.531	0.469
M21.83 Other specified acquired deformities of limbs (Forearm)	0.000	0.531	0.469
M21.82 Other specified acquired deformities of limbs (Upper arm)	0.000	0.531	0.469
M21.81 Other specified acquired deformities of limbs (Shoulder region)	0.000	0.531	0.469
M21.80 Other specified acquired deformities of limbs (Multiple sites)	0.000	0.531	0.469
M21.97 Acquired deformity of limb, unspecified (Ankle and foot)	0.000	0.532	0.468
E11.2 With renal complications	0.000	0.533	0.467
M24.2 Disorder of ligament	0.000	0.533	0.467
M21.76 Unequal limb length (acquired) (Lower leg)	0.000	0.534	0.465
M21.99 Acquired deformity of limb, unspecified (Site unspecified)	0.000	0.535	0.465
M21.98 Acquired deformity of limb, unspecified-Other	0.000	0.535	0.465
M21.96 Acquired deformity of limb, unspecified (Lower leg)	0.000	0.535	0.465
M21.95 Acquired deformity of limb, unspecified (Pelvic region and thigh)	0.000	0.535	0.465
M21.93 Acquired deformity of limb, unspecified (Forearm)	0.000	0.535	0.465
M21.92 Acquired deformity of limb, unspecified (Upper arm)	0.000	0.535	0.465
M21.91 Acquired deformity of limb, unspecified (Shoulder region)	0.000	0.535	0.465
M21.90 Acquired deformity of limb, unspecified (Multiple sites)	0.000	0.535	0.465
M21.85 Other specified acquired deformities of limbs (Pelvic region and thigh)	0.000	0.536	0.464
M07.3 Other psoriatic arthropathies	0.463	0.537	0.000
E06.5 Other chronic thyroiditis	0.000	0.538	0.461
M24.13 Other articular cartilage disorders (Forearm)	0.000	0.539	0.461
E11.6 With other specified complications	0.000	0.541	0.459
M21.39 Wrist or foot drop (acquired)-Site unspec	0.000	0.544	0.456
M21.38 Wrist or foot drop (acquired)-Other	0.000	0.544	0.456
M21.36 Wrist or foot drop (acquired)-Lower leg	0.000	0.544	0.456
M21.35 Wrist or foot drop (acquired)-Pelvic/thigh	0.000	0.544	0.456
M21.34 Wrist or foot drop (acquired) (Hand)	0.000	0.544	0.456
M21.32 Wrist or foot drop (acquired)-Upper arm	0.000	0.544	0.456
M21.31 Wrist or foot drop (acquired)-Shldr region	0.000	0.544	0.456
M21.30 Wrist or foot drop (acquired) (Multiple sites)	0.000	0.544	0.456
M33 Dermatopolymyositis	0.001	0.544	0.455
M21.69 Other acquired deformities of ankle and foot-Site unspec	0.000	0.546	0.454
M21.68 Other acquired deformities of ankle and foot-Other	0.000	0.546	0.454
M21.66 Other acquired deformities of ankle and foot-Lower leg	0.000	0.546	0.454
M21.65 Other acquired deformities of ankle and foot-Pelvic/thigh	0.000	0.546	0.454
M21.64 Other acquired deformities of ankle and foot-Hand	0.000	0.546	0.454
M21.63 Other acquired deformities of ankle and foot-Forearm	0.000	0.546	0.454
M21.62 Other acquired deformities of ankle and foot-Upper arm	0.000	0.546	0.454
M21.61 Other acquired deformities of ankle and foot-Shldr region	0.000	0.546	0.454
M21.60 Other acquired deformities of ankle and foot-Mult sites	0.000	0.546	0.454
E20-E35 Disorders of other endocrine glands	0.000	0.546	0.454
M31.7 Microscopic polyangiitis	0.000	0.548	0.452
M21.94 Acquired deformity of limb, unspecified (Hand)	0.000	0.549	0.451
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.000	0.553	0.446
E13.8 With unspecified complications	0.000	0.553	0.446
E13.7 With multiple complications	0.000	0.553	0.446
E13.6 With other specified complications	0.000	0.553	0.446
E13.5 With peripheral circulatory complications	0.000	0.553	0.446
E13.4 With neurological complications	0.000	0.553	0.446
E13.3 With ophthalmic complications	0.000	0.553	0.446
E13.2 With renal complications	0.000	0.553	0.446
E13.1 With ketoacidosis	0.000	0.553	0.446
E13.0 With coma	0.000	0.553	0.446
E07.8 Other specified disorders of thyroid	0.000	0.554	0.446
M22 Disorders of patella	0.000	0.555	0.445
E11.7 With multiple complications	0.000	0.555	0.445
M25.31 Other instability of joint (Shoulder region)	0.000	0.561	0.439
E04.8 Other specified non-toxic goitre	0.000	0.561	0.439
E07.1 Dyshormogenetic goitre	0.000	0.561	0.439
E07.0 Hypersecretion of calcitonin	0.000	0.561	0.439
M24.9 Joint derangement, unspecified	0.000	0.563	0.437
E61.2 Magnesium deficiency	0.000	0.564	0.436
E55.0 Rickets, active	0.000	0.566	0.434
M31.3 Wegener's granulomatosis	0.000	0.567	0.432
M24.01 Loose body in joint (Shoulder region)	0.000	0.571	0.429
M21.67 Other acquired deformities of ankle and foot-Ankle/foot	0.000	0.572	0.428
M25.36 Other instability of joint (Lower leg)	0.000	0.575	0.425
E34 Other endocrine disorders	0.000	0.577	0.423
E44 Protein-energy malnutrition of moderate and mild degree	0.000	0.579	0.421
E45 Retarded development following protein-energy malnutrition	0.000	0.579	0.421
E43 Unspecified severe protein-energy malnutrition	0.000	0.579	0.421
E42 Marasmic kwashiorkor	0.000	0.579	0.421
E41 Nutritional marasmus	0.000	0.579	0.421
E40 Kwashiorkor	0.000	0.579	0.421
M24.02 Loose body in joint (Upper arm)	0.000	0.581	0.419
M21.33 Wrist or foot drop (acquired) (Forearm)	0.000	0.588	0.412
M24.27 Disorder of ligament (Ankle and foot)	0.000	0.588	0.412
M07.30 Other psoriatic arthropathies (Multiple sites)	0.412	0.588	0.000
M25.83 Other specified joint disorders (Forearm)	0.000	0.590	0.409
E53.1 Pyridoxine deficiency	0.000	0.591	0.409
E53.0 Riboflavin deficiency	0.000	0.591	0.409
M25.39 Other instability of joint (Site unspecified)	0.000	0.591	0.408
M25.38 Other instability of joint (Other)	0.000	0.591	0.408
M25.35 Other instability of joint (Pelvic region and thigh)	0.000	0.591	0.408
M25.32 Other instability of joint (Upper arm)	0.000	0.591	0.408
M25.30 Other instability of joint (Multiple sites)	0.000	0.591	0.408
M24.19 Other articular cartilage disorders (Site unspecified)	0.000	0.591	0.408
M24.18 Other articular cartilage disorders (Other)	0.000	0.591	0.408
M24.14 Other articular cartilage disorders (Hand)	0.000	0.591	0.408
M24.12 Other articular cartilage disorders (Upper arm)	0.000	0.591	0.408
M24.10 Other articular cartilage disorders (Multiple sites)	0.000	0.591	0.408
M21.17 Varus deformity, not elsewhere classified (Ankle and foot)	0.000	0.593	0.407
E50.9 Vitamin A deficiency, unspecified	0.000	0.599	0.401
E50.8 Other manifestations of vitamin A deficiency	0.000	0.599	0.401
E50.7 Other ocular manifestations of vitamin A deficiency	0.000	0.599	0.401
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.000	0.599	0.401
E50.5 Vitamin A deficiency with night blindness	0.000	0.599	0.401
E50.4 Vitamin A deficiency with keratomalacia	0.000	0.599	0.401
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.000	0.599	0.401
E50.2 Vitamin A deficiency with corneal xerosis	0.000	0.599	0.401
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.000	0.599	0.401
E50.0 Vitamin A deficiency with conjunctival xerosis	0.000	0.599	0.401
E51.9 Thiamine deficiency, unspecified	0.000	0.599	0.401
E51.8 Other manifestations of thiamine deficiency	0.000	0.599	0.401
E51.2 Wernicke's encephalopathy	0.000	0.599	0.401
E51.1 Beriberi	0.000	0.599	0.401
E63.9 Nutritional deficiency, unspecified	0.000	0.599	0.401
E63.8 Other specified nutritional deficiencies	0.000	0.599	0.401
E63.1 Imbalance of constituents of food intake	0.000	0.599	0.401
E63.0 Essential fatty acid [EFA] deficiency	0.000	0.599	0.401
E64.9 Sequelae of unspecified nutritional deficiency	0.000	0.599	0.401
E64.8 Sequelae of other nutritional deficiencies	0.000	0.599	0.401
E64.3 Sequelae of rickets	0.000	0.599	0.401
E64.2 Sequelae of vitamin C deficiency	0.000	0.599	0.401
E64.1 Sequelae of vitamin A deficiency	0.000	0.599	0.401
E64.0 Sequelae of protein-energy malnutrition	0.000	0.599	0.401
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.000	0.600	0.400
M21.2 Flexion deformity	0.000	0.600	0.400
E61.9 Deficiency of nutrient element, unspecified	0.000	0.601	0.399
E61.8 Deficiency of other specified nutrient elements	0.000	0.601	0.399
E61.7 Deficiency of multiple nutrient elements	0.000	0.601	0.399
E61.6 Vanadium deficiency	0.000	0.601	0.399
E61.5 Molybdenum deficiency	0.000	0.601	0.399
E61.4 Chromium deficiency	0.000	0.601	0.399
E61.3 Manganese deficiency	0.000	0.601	0.399
E61.0 Copper deficiency	0.000	0.601	0.399
E56.9 Vitamin deficiency, unspecified	0.000	0.601	0.398
E56.8 Deficiency of other vitamins	0.000	0.601	0.398
E56.0 Deficiency of vitamin E	0.000	0.601	0.398
M24.7 Protrusio acetabuli	0.000	0.604	0.396
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)	0.395	0.605	0.000
E56.1 Deficiency of vitamin K	0.000	0.605	0.395
E27 Other disorders of adrenal gland	0.000	0.606	0.394
M24.5 Contracture of joint	0.000	0.606	0.394
E11.0 With coma	0.000	0.606	0.394
M23 Internal derangement of knee	0.000	0.607	0.393
M32.90 Systemic lupus erythematosus, unspecified, Multiple sites	0.000	0.609	0.391
K90.9 Intestinal malabsorption, unspecified	0.000	0.610	0.390
E04.0 Non-toxic diffuse goitre	0.000	0.611	0.389
E27.1 Primary adrenocortical insufficiency	0.000	0.616	0.384
M07.38 Other psoriatic arthropathies (Other)	0.384	0.616	0.000
M21.59 Acquired clawhand, clubhand, clawfoot and clubfoot-Site uns	0.000	0.619	0.380
M21.58 Acquired clawhand, clubhand, clawfoot and clubfoot-Other	0.000	0.619	0.380
M21.56 Acquired clawhand, clubhand, clawfoot and clubfoot-Lower le	0.000	0.619	0.380
M21.55 Acquired clawhand, clubhand, clawfoot and clubfoot-Pelvic/t	0.000	0.619	0.380
M21.53 Acquired clawhand, clubhand, clawfoot and clubfoot-Forearm	0.000	0.619	0.380
M21.52 Acquired clawhand, clubhand, clawfoot and clubfoot-Upper ar	0.000	0.619	0.380
M21.51 Acquired clawhand, clubhand, clawfoot and clubfoot-Shldr re	0.000	0.619	0.380
M21.50 Acquired clawhand, clubhand, clawfoot and clubfoot (Multiple sites)	0.000	0.619	0.380
M25.33 Other instability of joint (Forearm)	0.000	0.620	0.380
M22.4 Chondromalacia patellae	0.000	0.623	0.377
E11.4 With neurological complications	0.000	0.627	0.373
M24.04 Loose body in joint (Hand)	0.000	0.628	0.372
M24.21 Disorder of ligament (Shoulder region)	0.000	0.629	0.371
M07.34 Other psoriatic arthropathies (Hand)	0.371	0.629	0.000
M25.50 Pain in joint (Multiple sites)	0.000	0.629	0.371
E34.8 Other specified endocrine disorders	0.000	0.630	0.370
M07.31 Other psoriatic arthropathies (Shoulder region)	0.365	0.635	0.000
K90.8 Other intestinal malabsorption	0.000	0.636	0.364
M24.4 Recurrent dislocation and subluxation of joint	0.000	0.636	0.364
M24.09 Loose body in joint (Site unspecified)	0.000	0.640	0.360
M24.08 Loose body in joint (Other)	0.000	0.640	0.360
M24.06 Loose body in joint-Lower leg	0.000	0.640	0.360
M24.05 Loose body in joint (Pelvic region and thigh)	0.000	0.640	0.360
M24.00 Loose body in joint (Multiple sites)	0.000	0.640	0.360
M25.34 Other instability of joint (Hand)	0.000	0.642	0.358
M24.03 Loose body in joint (Forearm)	0.000	0.644	0.356
E34.0 Carcinoid syndrome	0.000	0.646	0.354
M07.37 Other psoriatic arthropathies (Ankle and foot)	0.353	0.646	0.000
E22 Hyperfunction of pituitary gland	0.000	0.647	0.353
E13.9 Without complications	0.000	0.648	0.352
K90.3 Pancreatic steatorrhoea	0.000	0.648	0.352
K90.2 Blind loop syndrome, not elsewhere classified	0.000	0.648	0.352
K90.1 Tropical sprue	0.000	0.648	0.352
E61.1 Iron deficiency	0.000	0.653	0.347
E29 Testicular dysfunction	0.000	0.660	0.340
E34.9 Endocrine disorder, unspecified	0.000	0.664	0.336
M25.88 Other specified joint disorders (Other)	0.000	0.664	0.335
M22.9 Disorder of patella, unspecified	0.000	0.665	0.335
M24.29 Disorder of ligament (Site unspecified)	0.000	0.665	0.335
M24.25 Disorder of ligament (Pelvic region and thigh)	0.000	0.665	0.335
M24.22 Disorder of ligament (Upper arm)	0.000	0.665	0.335
M24.20 Disorder of ligament (Multiple sites)	0.000	0.665	0.335
M25.4 Effusion of joint	0.000	0.668	0.332
M07.33 Other psoriatic arthropathies (Forearm)	0.332	0.668	0.000
M07.32 Other psoriatic arthropathies (Upper arm)	0.332	0.668	0.000
M33.9 Dermatopolymyositis, unspecified	0.001	0.673	0.326
M33.0 Juvenile dermatomyositis	0.001	0.673	0.326
M21.54 Acquired clawhand, clubhand, clawfoot and clubfoot (Hand)	0.000	0.673	0.326
M21.57 Acquired clawhand, clubhand, clawfoot and clubfoot (Ankle and foot)	0.000	0.674	0.326

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations