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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2856705
log Bayes Factor = 51.1465
Chromosome 6   position 32,670,956  (GRCh37) Explore rs2856705 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
M35.3 Polymyalgia rheumatica
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
M35 Other systemic involvement of connective tissue
0.000 0.000 1.000
Chapter VII Diseases of the eye and adnexa
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.000 0.001 0.999
E03 Other hypothyroidism
0.000 0.001 0.999
M20-M25 Other joint disorders
0.000 0.001 0.999
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.001 0.999
H36 Retinal disorders in diseases classified elsewhere
0.000 0.002 0.998
E03.9 Hypothyroidism, unspecified
0.000 0.002 0.998
H30-H36 Disorders of choroid and retina
0.000 0.003 0.997
M05 Seropositive rheumatoid arthritis
0.000 0.003 0.997
E05.9 Thyrotoxicosis, unspecified
0.000 0.004 0.996
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.004 0.996
E10.1 With ketoacidosis
0.000 0.005 0.995
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.006 0.994
L20-L30 Dermatitis and eczema
0.000 0.008 0.992
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.009 0.991
H04 Disorders of lachrymal system
0.000 0.012 0.988
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.017 0.983
H02 Other disorders of eyelid
0.000 0.018 0.982
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.023 0.977
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.023 0.977
M35.0 Sicca syndrome [Sjogren]
0.000 0.024 0.976
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified
0.000 0.034 0.966
H04.5 Stenosis and insufficiency of lachrymal passages
0.000 0.034 0.966
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.034 0.966
E20-E35 Disorders of other endocrine glands
0.000 0.037 0.963
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.043 0.957
L30 Other dermatitis
0.000 0.046 0.954
E27 Other disorders of adrenal gland
0.000 0.050 0.950
H02.1 Ectropion of eyelid
0.000 0.053 0.947
H02.0 Entropion and trichiasis of eyelid
0.000 0.056 0.944
N48 Other disorders of penis
0.937 0.063 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.063 0.937
M34 Systemic sclerosis
0.000 0.068 0.932
N48.6 Balanitis xerotica obliterans
0.931 0.069 0.000
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.071 0.929
E10.5 With peripheral circulatory complications
0.000 0.076 0.924
L98.8 Other specified disorders of skin and subcutaneous tissue
0.000 0.077 0.923
Chapter X Diseases of the respiratory system
0.000 0.082 0.918
E11 Non-insulin-dependent diabetes mellitus
0.000 0.082 0.918
N40-N51 Diseases of male genital organs
0.916 0.084 0.000
M06.0 Seronegative rheumatoid arthritis
0.000 0.088 0.912
N47 Redundant prepuce, phimosis and paraphimosis
0.911 0.089 0.000
E11.3 With ophthalmic complications
0.000 0.090 0.910
L30.9 Dermatitis, unspecified
0.000 0.091 0.909
E10.4 With neurological complications
0.000 0.096 0.904
E06 Thyroiditis
0.000 0.098 0.902
L27 Dermatitis due to substances taken internally
0.000 0.099 0.901
L81 Other disorders of pigmentation
0.000 0.102 0.898
J80-J84 Other respiratory diseases principally affecting the interstitium
0.000 0.103 0.897
J20-J22 Other acute lower respiratory infections
0.000 0.105 0.895
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.105 0.895
N48.8 Other specified disorders of penis
0.894 0.106 0.000
D50-D53 Nutritional anaemias
0.000 0.107 0.893
H05 Disorders of orbit
0.000 0.110 0.890
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.111 0.889
D60-D64 Aplastic and other anaemias
0.000 0.114 0.886
L98.4 Chronic ulcer of skin, not elsewhere classified
0.000 0.117 0.883
E10.2 With renal complications
0.000 0.120 0.880
L29 Pruritus
0.000 0.121 0.879
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.121 0.879
Chapter V Mental and behavioural disorders
0.000 0.123 0.877
J22 Unspecified acute lower respiratory infection
0.000 0.125 0.875
M34.9 Systemic sclerosis, unspecified
0.000 0.136 0.864
N45 Orchitis and epididymitis
0.863 0.137 0.000
L81.4 Other melanin hyperpigmentation
0.000 0.137 0.863
D68 Other coagulation defects
0.000 0.140 0.860
D61 Other aplastic anaemias
0.000 0.142 0.858
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.142 0.858
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.143 0.857
L57.0 Actinic keratosis
0.000 0.146 0.854
M31 Other necrotising vasculopathies
0.000 0.146 0.854
J80 Adult respiratory distress syndrome
0.000 0.148 0.852
H55-H59 Other disorders of eye and adnexa
0.000 0.152 0.848
M60-M63 Disorders of muscles
0.000 0.153 0.847
F30-F39 Mood [affective] disorders
0.000 0.154 0.846
M06.3 Rheumatoid nodule
0.000 0.156 0.844
N48.0 Leukoplakia of penis
0.842 0.158 0.000
H04.8 Other disorders of lachrymal system
0.000 0.158 0.842
H04.2 Epiphora
0.000 0.160 0.840
L27.0 Generalised skin eruption due to drugs and medicaments
0.000 0.160 0.840
D61.9 Aplastic anaemia, unspecified
0.000 0.161 0.839
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.000 0.164 0.836
L98.0 Pyogenic granuloma
0.000 0.167 0.833
E28 Ovarian dysfunction
0.000 0.167 0.833
E06.3 Autoimmune thyroiditis
0.000 0.171 0.829
N45.9 Orchitis, epididymitis and epididymo-orchitis without abscess
0.828 0.172 0.000
J95-J99 Other diseases of the respiratory system
0.000 0.174 0.826
L83 Acanthosis nigricans
0.000 0.174 0.825
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.179 0.820
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.000 0.181 0.819
M35.1 Other overlap syndromes
0.000 0.181 0.819
N48.9 Disorder of penis, unspecified
0.817 0.183 0.000
L94 Other localised connective tissue disorders
0.000 0.184 0.816
L00-L08 Infections of the skin and subcutaneous tissue
0.000 0.185 0.815
H53-H54 Visual disturbances and blindness
0.000 0.193 0.807
J84 Other interstitial pulmonary diseases
0.000 0.195 0.805
F31 Bipolar affective disorder
0.000 0.199 0.801
L29.0 Pruritus ani
0.000 0.200 0.800
D50 Iron deficiency anaemia
0.000 0.202 0.798
L30.8 Other specified dermatitis
0.000 0.203 0.797
L93 Lupus erythematosus
0.000 0.205 0.795
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.210 0.790
H02.9 Disorder of eyelid, unspecified
0.000 0.212 0.788
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.214 0.786
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.216 0.784
E20 Hypoparathyroidism
0.000 0.217 0.783
E27.8 Other specified disorders of adrenal gland
0.000 0.218 0.782
J00-J06 Acute upper respiratory infections
0.000 0.220 0.780
D68.5 Primary Thrombophilia
0.000 0.220 0.780
N48.4 Impotence of organic origin
0.776 0.224 0.000
H02.6 Xanthelasma of eyelid
0.000 0.227 0.773
L80 Vitiligo
0.000 0.231 0.769
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.232 0.768
E50-E64 Other nutritional deficiencies
0.000 0.235 0.765
H05.2 Exophthalmic conditions
0.000 0.235 0.765
F32 Depressive episode
0.000 0.239 0.761
L85 Other epidermal thickening
0.000 0.241 0.759
G35 Multiple sclerosis
0.000 0.242 0.758
M31.3 Wegener's granulomatosis
0.000 0.242 0.758
E70-E90 Metabolic disorders
0.000 0.242 0.758
D52 Folate deficiency anaemia
0.000 0.245 0.755
E07 Other disorders of thyroid
0.000 0.245 0.755
L20 Atopic dermatitis
0.000 0.245 0.755
D62 Acute posthaemorrhagic anaemia
0.000 0.246 0.754
Chapter I Certain infectious and parasitic diseases
0.000 0.247 0.753
M62 Other disorders of muscle
0.000 0.250 0.750
E29 Testicular dysfunction
0.000 0.250 0.750
M34.1 CR(E)ST syndrome
0.000 0.252 0.748
N48.5 Ulcer of penis
0.747 0.253 0.000
J98 Other respiratory disorders
0.000 0.253 0.747
M35.7 Hypermobility syndrome
0.000 0.254 0.746
H55 Nystagmus and other irregular eye movements
0.000 0.254 0.746
M32 Systemic lupus erythematosus
0.000 0.254 0.746
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.256 0.744
J00 Acute nasopharyngitis [common cold]
0.000 0.257 0.743
L02 Cutaneous abscess, furuncle and carbuncle
0.000 0.258 0.742
E28.2 Polycystic ovarian syndrome
0.000 0.261 0.739
N49 Inflammatory disorders of male genital organs, not elsewhere classified
0.738 0.262 0.000
H05.0 Acute inflammation of orbit
0.000 0.262 0.738
M07 Psoriatic and enteropathic arthropathies
0.000 0.267 0.733
N44 Torsion of testis
0.733 0.267 0.000
B35-B49 Mycoses
0.000 0.267 0.733
M06.34 Rheumatoid nodule (Hand)
0.000 0.268 0.732
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.268 0.732
B37 Candidiasis
0.000 0.269 0.731
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.269 0.731
B37.8 Candidiasis of other sites
0.000 0.270 0.730
D68.0 Von Willebrand's disease
0.000 0.272 0.728
H04.4 Chronic inflammation of lachrymal passages
0.000 0.272 0.728
F20 Schizophrenia
0.000 0.273 0.727
M21 Other acquired deformities of limbs
0.000 0.273 0.727
F32.2 Severe depressive episode without psychotic symptoms
0.000 0.274 0.726
H53 Visual disturbances
0.000 0.275 0.725
L98.9 Disorder of skin and subcutaneous tissue, unspecified
0.000 0.275 0.725
H04.9 Disorder of lachrymal system, unspecified
0.000 0.276 0.724
E11.1 With ketoacidosis
0.000 0.277 0.723
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.278 0.722
D50.8 Other iron deficiency anaemias
0.000 0.278 0.722
E10.6 With other specified complications
0.000 0.278 0.722
H06.2 Dysthyroid exophthalmos
0.000 0.281 0.719
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.000 0.281 0.719
E04 Other non-toxic goitre
0.000 0.281 0.719
E05.8 Other thyrotoxicosis
0.000 0.282 0.718
L25 Unspecified contact dermatitis
0.000 0.283 0.717
E10.8 With unspecified complications
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E10.0 With coma
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
M12 Other specific arthropathies
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.283 0.717
M35.8 Other specified systemic involvement of connective tissue
0.000 0.283 0.717
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.283 0.717
M35.5 Multifocal fibrosclerosis
0.000 0.283 0.717
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.283 0.717
M35.2 Behcet's disease
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.284 0.716
E03.4 Atrophy of thyroid (acquired)
0.000 0.284 0.716
E03.3 Postinfectious hypothyroidism
0.000 0.284 0.716
E03.1 Congenital hypothyroidism without goitre
0.000 0.284 0.716
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.284 0.716
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.284 0.716
H02.5 Other disorders affecting eyelid function
0.000 0.284 0.716
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.284 0.716
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.284 0.716
E11.2 With renal complications
0.000 0.285 0.715
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.285 0.715
H30 Chorioretinal inflammation
0.000 0.285 0.715
M05.8 Other seropositive rheumatoid arthritis
0.000 0.285 0.715
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.285 0.715
M05.2 Rheumatoid vasculitis
0.000 0.285 0.715
M05.1 Rheumatoid lung disease
0.000 0.285 0.715
M05.0 Felty's syndrome
0.000 0.285 0.715
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.286 0.714
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.286 0.714
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.286 0.714
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.286 0.714
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.286 0.714
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.286 0.714
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.286 0.714
Chapter VI Diseases of the nervous system
0.000 0.287 0.713
L24 Irritant contact dermatitis
0.000 0.289 0.711
L21 Seborrhoeic dermatitis
0.000 0.289 0.711
L26 Exfoliative dermatitis
0.000 0.289 0.711
L22 Diaper [napkin] dermatitis
0.000 0.289 0.711
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.289 0.711
H04.3 Acute and unspecified inflammation of lachrymal passages
0.000 0.289 0.711
N41 Inflammatory diseases of prostate
0.711 0.289 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.290 0.710
J20 Acute bronchitis
0.000 0.291 0.709
H04.6 Other changes in lachrymal passages
0.000 0.291 0.709
H04.0 Dacryoadenitis
0.000 0.291 0.709
D68.9 Coagulation defect, unspecified
0.000 0.294 0.706
H02.7 Other degenerative disorders of eyelid and periocular area
0.000 0.296 0.704
E27.2 Addisonian crisis
0.000 0.299 0.701
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.000 0.300 0.700
L87 Transepidermal elimination disorders
0.000 0.300 0.700
L88 Pyoderma gangrenosum
0.000 0.300 0.700
L86 Keratoderma in diseases classified elsewhere
0.000 0.300 0.700
M65-M68 Disorders of synovium and tendon
0.000 0.300 0.700
J84.9 Interstitial pulmonary disease, unspecified
0.000 0.301 0.699
L02.4 Cutaneous abscess, furuncle and carbuncle of limb
0.000 0.302 0.698
D68.8 Other specified coagulation defects
0.000 0.302 0.698
H01 Other inflammation of eyelid
0.000 0.303 0.697
L23 Allergic contact dermatitis
0.000 0.303 0.696
H53.9 Visual disturbance, unspecified
0.000 0.304 0.696
M62.8 Other specified disorders of muscle
0.000 0.307 0.693
H57 Other disorders of eye and adnexa
0.000 0.307 0.693
L98.7 Excessive and redundant skin and subcutaneous tissue
0.000 0.307 0.693
L98.6 Other infiltrative disorders of skin and subcutaneous tissue
0.000 0.307 0.693
L98.5 Mucinosis of skin
0.000 0.307 0.693
L98.3 Eosinophilic cellulitis [Wells]
0.000 0.307 0.693
L98.1 Factitial dermatitis
0.000 0.307 0.693
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.309 0.691
E32 Diseases of thymus
0.000 0.309 0.691
E31 Polyglandular dysfunction
0.000 0.309 0.691
E30 Disorders of puberty, not elsewhere classified
0.000 0.309 0.691
H02.2 Lagophthalmos
0.000 0.311 0.688
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.312 0.688
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.314 0.686
L58 Radiodermatitis
0.000 0.314 0.686
L55 Sunburn
0.000 0.314 0.686
L95 Vasculitis limited to skin, not elsewhere classified
0.000 0.315 0.685
F32.1 Moderate depressive episode
0.000 0.315 0.685
M21.0 Valgus deformity, not elsewhere classified
0.000 0.315 0.685
L30.5 Pityriasis alba
0.000 0.316 0.684
L30.4 Erythema intertrigo
0.000 0.316 0.684
L30.3 Infective dermatitis
0.000 0.316 0.684
L30.2 Cutaneous autosensitisation
0.000 0.316 0.684
L30.1 Dyshidrosis [pompholyx]
0.000 0.316 0.684
L30.0 Nummular dermatitis
0.000 0.316 0.684
M06.4 Inflammatory polyarthropathy
0.000 0.317 0.683
J95 Postprocedural respiratory disorders, not elsewhere classified
0.000 0.317 0.683
E27.5 Adrenomedullary hyperfunction
0.000 0.319 0.681
E27.0 Other adrenocortical overactivity
0.000 0.319 0.681
E27.9 Disorder of adrenal gland, unspecified
0.000 0.320 0.680
L02.2 Cutaneous abscess, furuncle and carbuncle of trunk
0.000 0.321 0.679
A50-A64 Infections with a predominantly sexual mode of transmission
0.000 0.322 0.678
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.324 0.676
E23 Hypofunction and other disorders of pituitary gland
0.000 0.324 0.676
E11.0 With coma
0.000 0.324 0.676
E14 Unspecified diabetes mellitus
0.000 0.325 0.675
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.327 0.673
L08 Other local infections of skin and subcutaneous tissue
0.000 0.327 0.673
N48.3 Priapism
0.672 0.328 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.329 0.671
L29.9 Pruritus, unspecified
0.000 0.329 0.671
E03.8 Other specified hypothyroidism
0.000 0.331 0.669
M34.8 Other forms of systemic sclerosis
0.000 0.332 0.668
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.332 0.668
M34.0 Progressive systemic sclerosis
0.000 0.332 0.668
B37.0 Candidal stomatitis
0.000 0.334 0.666
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.334 0.666
L57.5 Actinic granuloma
0.000 0.334 0.666
L57.3 Poikiloderma of Civatte
0.000 0.334 0.666
L57.2 Cutis rhomboidalis nuchae
0.000 0.334 0.666
L57.1 Actinic reticuloid
0.000 0.334 0.666
L93.0 Discoid lupus erythematosus
0.000 0.335 0.665
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.336 0.664
E26 Hyperaldosteronism
0.000 0.336 0.664
J98.4 Other disorders of lung
0.000 0.337 0.663
M00-M03 Infectious arthropathies
0.000 0.338 0.662
L57.4 Cutis laxa senilis
0.000 0.339 0.661
F23 Acute and transient psychotic disorders
0.000 0.340 0.660
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.342 0.658
F80-F89 Disorders of psychological development
0.000 0.342 0.658
E11.7 With multiple complications
0.000 0.342 0.658
L28 Lichen simplex chronicus and prurigo
0.000 0.342 0.658
F30 Manic episode
0.000 0.342 0.657
E89.0 Postprocedural hypothyroidism
0.000 0.343 0.657
D52.9 Folate deficiency anaemia, unspecified
0.000 0.343 0.657
N51 Disorders of male genital organs in diseases classified elsewhere
0.657 0.343 0.000
F34 Persistent mood [affective] disorders
0.000 0.343 0.656
F31.0 Bipolar affective disorder, current episode hypomanic
0.000 0.345 0.655
E06.9 Thyroiditis, unspecified
0.000 0.345 0.654
L94.0 Localised scleroderma [morphea]
0.000 0.346 0.654
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.346 0.654
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.346 0.654
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.346 0.654
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.346 0.654
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.346 0.654
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.346 0.654
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.346 0.654
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.346 0.654
E20.9 Hypoparathyroidism, unspecified
0.000 0.346 0.654
F22 Persistent delusional disorders
0.000 0.346 0.653
F00-F09 Organic, including symptomatic, mental disorders
0.000 0.347 0.653
F31.9 Bipolar affective disorder, unspecified
0.000 0.348 0.652
E11.8 With unspecified complications
0.000 0.348 0.652
J81 Pulmonary oedema
0.000 0.349 0.651
L94.2 Calcinosis cutis
0.000 0.349 0.651
D51 Vitamin B12 deficiency anaemia
0.000 0.349 0.651
D68.6 Other Thrombophilia
0.000 0.350 0.650
M30 Polyarteritis nodosa and related conditions
0.000 0.351 0.649
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.000 0.352 0.648
J84.1 Other interstitial pulmonary diseases with fibrosis
0.000 0.352 0.648
E06.5 Other chronic thyroiditis
0.000 0.353 0.647
E06.4 Drug-induced thyroiditis
0.000 0.353 0.647
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.353 0.647
E06.1 Subacute thyroiditis
0.000 0.353 0.647
E06.0 Acute thyroiditis
0.000 0.353 0.647
L27.9 Dermatitis due to unspecified substance taken internally
0.000 0.354 0.646
L27.8 Dermatitis due to other substances taken internally
0.000 0.354 0.646
L27.2 Dermatitis due to ingested food
0.000 0.354 0.646
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.000 0.356 0.644
L81.7 Pigmented purpuric dermatosis
0.000 0.356 0.644
L81.6 Other disorders of diminished melanin formation
0.000 0.356 0.644
L81.5 Leukoderma, not elsewhere classified
0.000 0.356 0.644
L81.3 Cafe au lait spots
0.000 0.356 0.644
L81.2 Freckles
0.000 0.356 0.644
L81.1 Chloasma
0.000 0.356 0.644
L81.0 Postinflammatory hyperpigmentation
0.000 0.356 0.644
N46 Male infertility
0.643 0.356 0.000
J98.0 Diseases of bronchus, not elsewhere classified
0.000 0.358 0.642
M21.06 Valgus deformity, not elsewhere classified (Lower leg)
0.000 0.358 0.642
J82 Pulmonary eosinophilia, not elsewhere classified
0.000 0.359 0.641
L81.8 Other specified disorders of pigmentation
0.000 0.359 0.641
E53 Deficiency of other B group vitamins
0.000 0.359 0.641
F20.0 Paranoid schizophrenia
0.000 0.361 0.639
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.000 0.361 0.639
H05.9 Disorder of orbit, unspecified
0.000 0.362 0.638
H05.5 Retained (old) foreign body following penetrating wound of orbit
0.000 0.362 0.638
H05.4 Enophthalmos
0.000 0.362 0.638
H05.3 Deformity of orbit
0.000 0.362 0.638
H05.1 Chronic inflammatory disorders of orbit
0.000 0.362 0.638
D67 Hereditary factor IX deficiency
0.000 0.362 0.638
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.362 0.638
M11 Other crystal arthropathies
0.000 0.364 0.636
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.365 0.635
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.365 0.635
N48.1 Balanoposthitis
0.632 0.368 0.000
J98.9 Respiratory disorder, unspecified
0.000 0.368 0.632
M62.80 Other specified disorders of muscle (Multiple sites)
0.000 0.368 0.632
H16 Keratitis
0.000 0.369 0.631
N50 Other disorders of male genital organs
0.631 0.369 0.000
L29.3 Anogenital pruritus, unspecified
0.000 0.370 0.630
L29.1 Pruritus scroti
0.000 0.370 0.630
H05.8 Other disorders of orbit
0.000 0.370 0.629
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.000 0.371 0.629
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.000 0.371 0.629
L27.1 Localised skin eruption due to drugs and medicaments
0.000 0.372 0.628
M14 Arthropathies in other diseases classified elsewhere
0.000 0.373 0.627
H03 Disorders of eyelid in diseases classified elsewhere
0.000 0.374 0.626
A63 Other predominantly sexually transmitted diseases, not elsewhere classified
0.000 0.374 0.626
L05 Pilonidal cyst
0.000 0.374 0.626
M33 Dermatopolymyositis
0.000 0.375 0.625
F39 Unspecified mood [affective] disorder
0.000 0.377 0.622
D53 Other nutritional anaemias
0.000 0.378 0.622
L29.8 Other pruritus
0.000 0.379 0.621
N48.2 Other inflammatory disorders of penis
0.621 0.379 0.000
L10-L14 Bullous disorders
0.000 0.379 0.621
F70-F79 Mental retardation
0.000 0.382 0.618
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.382 0.618
D55-D59 Haemolytic anaemias
0.000 0.382 0.617
D68.4 Acquired coagulation factor deficiency
0.000 0.384 0.616
D68.1 Hereditary factor XI deficiency
0.000 0.384 0.616
D61.8 Other specified aplastic anaemias
0.000 0.385 0.615
D61.3 Idiopathic aplastic anaemia
0.000 0.385 0.615
D61.2 Aplastic anaemia due to other external agents
0.000 0.385 0.615
D61.1 Drug-induced aplastic anaemia
0.000 0.385 0.615
D61.0 Constitutional aplastic anaemia
0.000 0.385 0.615
L08.9 Local infection of skin and subcutaneous tissue, unspecified
0.000 0.386 0.614
D68.2 Hereditary deficiency of other clotting factors
0.000 0.387 0.613
J21 Acute bronchiolitis
0.000 0.387 0.613
M31.9 Necrotising vasculopathy, unspecified
0.000 0.387 0.612
M31.8 Other specified necrotising vasculopathies
0.000 0.387 0.612
M31.7 Microscopic polyangiitis
0.000 0.387 0.612
M31.4 Aortic arch syndrome [Takayasu]
0.000 0.387 0.612
M31.2 Lethal midline granuloma
0.000 0.387 0.612
M31.1 Thrombotic microangiopathy
0.000 0.387 0.612
M31.0 Hypersensitivity angiitis
0.000 0.387 0.612
B07 Viral warts
0.000 0.388 0.612
N49.2 Inflammatory disorders of scrotum
0.611 0.389 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.000 0.389 0.610
L85.8 Other specified epidermal thickening
0.000 0.390 0.610
H58 Other disorders of eye and adnexa in diseases classified elsewhere
0.000 0.390 0.610
E04.0 Non-toxic diffuse goitre
0.000 0.392 0.608
M63 Disorders of muscle in diseases classified elsewhere
0.000 0.393 0.607
M61 Calcification and ossification of muscle
0.000 0.393 0.607
F38 Other mood [affective] disorders
0.000 0.393 0.607
N45.0 Orchitis, epididymitis and epididymo-orchitis with abscess
0.607 0.393 0.000
F25 Schizoaffective disorders
0.000 0.393 0.606
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.395 0.605
M06.38 Rheumatoid nodule (Other)
0.000 0.395 0.605
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.395 0.605
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.395 0.605
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.395 0.605
M06.33 Rheumatoid nodule (Forearm)
0.000 0.395 0.605
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.395 0.605
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.395 0.605
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.395 0.605
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.395 0.605
M22 Disorders of patella
0.000 0.396 0.604
J01 Acute sinusitis
0.000 0.396 0.603
J84.8 Other specified interstitial pulmonary diseases
0.000 0.397 0.603
E16 Other disorders of pancreatic internal secretion
0.000 0.398 0.602
E25 Adrenogenital disorders
0.000 0.399 0.601
H06.3 Other disorders of orbit in diseases classified elsewhere
0.000 0.400 0.599
H06.1 Parasitic infestation of orbit in diseases classified elsewhere
0.000 0.400 0.599
H06.0 Disorders of lachrymal system in diseases classified elsewhere
0.000 0.400 0.599
E28.9 Ovarian dysfunction, unspecified
0.000 0.403 0.597
E28.8 Other ovarian dysfunction
0.000 0.403 0.597
E28.3 Primary ovarian failure
0.000 0.403 0.597
E28.1 Androgen excess
0.000 0.403 0.597
E28.0 Oestrogen excess
0.000 0.403 0.597
E29.1 Testicular hypofunction
0.000 0.403 0.597
L92 Granulomatous disorders of skin and subcutaneous tissue
0.000 0.403 0.597
J96 Respiratory failure, not elsewhere classified
0.000 0.408 0.592
L84 Corns and callosities
0.000 0.408 0.591
H53.0 Amblyopia ex anopsia
0.000 0.409 0.591
J04 Acute laryngitis and tracheitis
0.000 0.409 0.591
L82 Seborrhoeic keratosis
0.000 0.410 0.590
H10-H13 Disorders of conjunctiva
0.000 0.410 0.590
L98.2 Febrile neutrophilic dermatosis [Sweet]
0.000 0.410 0.590
A63.0 Anogenital (venereal) warts
0.000 0.411 0.589
E07.8 Other specified disorders of thyroid
0.000 0.411 0.589
F28 Other nonorganic psychotic disorders
0.000 0.412 0.587
F24 Induced delusional disorder
0.000 0.412 0.587
F21 Schizotypal disorder
0.000 0.412 0.587
J20.9 Acute bronchitis, unspecified
0.000 0.413 0.587
F29 Unspecified nonorganic psychosis
0.000 0.413 0.587
H04.1 Other disorders of lachrymal gland
0.000 0.413 0.587
J95.0 Tracheostomy malfunction
0.000 0.414 0.586
L94.9 Localised connective tissue disorder, unspecified
0.000 0.415 0.585
L94.8 Other specified localised connective tissue disorders
0.000 0.415 0.585
L94.6 Ainhum
0.000 0.415 0.585
L94.5 Poikiloderma vasculare atrophicans
0.000 0.415 0.585
L94.4 Gottron's papules
0.000 0.415 0.585
L94.3 Sclerodactyly
0.000 0.415 0.585
L94.1 Linear scleroderma
0.000 0.415 0.585
L20.9 Atopic dermatitis, unspecified
0.000 0.415 0.585
L01 Impetigo
0.000 0.416 0.584
L00 Staphylococcal scalded skin syndrome
0.000 0.416 0.584
L29.2 Pruritus vulvae
0.000 0.418 0.582
N41.0 Acute prostatitis
0.582 0.418 0.000
J98.5 Diseases of mediastinum, not elsewhere classified
0.000 0.418 0.582
E88 Other metabolic disorders
0.000 0.419 0.581
H53.2 Diplopia
0.000 0.420 0.580
M65 Synovitis and tenosynovitis
0.000 0.420 0.580
H46 Optic neuritis
0.000 0.421 0.579
E73 Lactose intolerance
0.000 0.422 0.578
J84.0 Alveolar and parietoalveolar conditions
0.000 0.422 0.577
F32.3 Severe depressive episode with psychotic symptoms
0.000 0.423 0.577
M60 Myositis
0.000 0.423 0.576
E65-E68 Obesity and other hyperalimentation
0.000 0.424 0.576
F31.8 Other bipolar affective disorders
0.000 0.426 0.574
F31.7 Bipolar affective disorder, currently in remission
0.000 0.426 0.574
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms
0.000 0.426 0.574
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms
0.000 0.426 0.574
E22 Hyperfunction of pituitary gland
0.000 0.426 0.574

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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