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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2857178
log Bayes Factor = 52.23
Chromosome 6   position 32,752,788  (GRCh37) Explore rs2857178 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
C44 Other malignant neoplasms of skin
0.000 0.000 1.000
M07.3 Other psoriatic arthropathies
0.000 0.000 1.000
M07 Psoriatic and enteropathic arthropathies
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
L40 Psoriasis
0.000 0.001 0.999
C44.7 Skin of lower limb, including hip
0.000 0.001 0.999
M05 Seropositive rheumatoid arthritis
0.000 0.001 0.999
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.001 0.999
L57.0 Actinic keratosis
0.000 0.002 0.998
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.002 0.998
C44.6 Skin of upper limb, including shoulder
0.000 0.003 0.997
E10.3 With ophthalmic complications
0.000 0.003 0.997
E05.9 Thyrotoxicosis, unspecified
0.000 0.003 0.997
L40.9 Psoriasis, unspecified
0.000 0.003 0.997
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.004 0.996
E70-E90 Metabolic disorders
0.000 0.004 0.996
E20-E35 Disorders of other endocrine glands
0.000 0.007 0.993
E78.0 Pure hypercholesterolaemia
0.000 0.008 0.992
C44.3 Skin of other and unspecified parts of face
0.000 0.008 0.992
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.009 0.991
E10.9 Without complications
0.000 0.009 0.991
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.009 0.991
G35-G37 Demyelinating diseases of the central nervous system
0.989 0.011 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.012 0.988
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.014 0.986
G37 Other demyelinating diseases of central nervous system
0.985 0.015 0.000
E23 Hypofunction and other disorders of pituitary gland
0.000 0.015 0.985
G37.9 Demyelinating disease of central nervous system, unspecified
0.980 0.020 0.000
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.023 0.977
E83.1 Disorders of iron metabolism
0.977 0.023 0.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.030 0.970
L40-L45 Papulosquamous disorders
0.000 0.039 0.961
C43-C44 Melanoma and other malignant neoplasms of skin
0.000 0.048 0.952
E78.5 Hyperlipidaemia, unspecified
0.000 0.057 0.943
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.058 0.942
C44.4 Skin of scalp and neck
0.000 0.064 0.936
E11.3 With ophthalmic complications
0.000 0.073 0.927
E23.6 Other disorders of pituitary gland
0.000 0.075 0.925
E27 Other disorders of adrenal gland
0.000 0.076 0.924
E23.7 Disorder of pituitary gland, unspecified
0.000 0.080 0.920
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.081 0.919
C44.2 Skin of ear and external auricular canal
0.000 0.084 0.916
E11.9 Without complications
0.000 0.090 0.910
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.000 0.090 0.910
D00-D09 In situ neoplasms
0.000 0.093 0.907
Chapter II Neoplasms
0.000 0.093 0.907
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.094 0.906
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.094 0.906
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.097 0.903
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.000 0.099 0.901
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.104 0.896
D06 Carcinoma in situ of cervix uteri
0.000 0.105 0.895
D04 Carcinoma in situ of skin
0.000 0.106 0.894
C83 Diffuse non-Hodgkin's lymphoma
0.000 0.107 0.893
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.000 0.109 0.891
C44.0 Skin of lip
0.000 0.111 0.889
D06.9 Cervix, unspecified
0.000 0.114 0.886
C83.3 Large cell (diffuse)
0.000 0.116 0.884
E10.1 With ketoacidosis
0.000 0.118 0.882
G37.8 Other specified demyelinating diseases of central nervous system
0.881 0.119 0.000
M06.0 Seronegative rheumatoid arthritis
0.000 0.120 0.880
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.120 0.880
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.122 0.878
E10.5 With peripheral circulatory complications
0.000 0.126 0.874
L43 Lichen planus
0.000 0.140 0.860
E10.0 With coma
0.000 0.144 0.856
E89.0 Postprocedural hypothyroidism
0.000 0.150 0.850
E27.1 Primary adrenocortical insufficiency
0.000 0.152 0.848
M10 Gout
0.000 0.158 0.842
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.158 0.842
E78.6 Lipoprotein deficiency
0.000 0.161 0.839
E23.2 Diabetes insipidus
0.000 0.169 0.831
E06 Thyroiditis
0.000 0.169 0.831
E78.2 Mixed hyperlipidaemia
0.000 0.171 0.829
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.000 0.171 0.829
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.000 0.176 0.824
L40.1 Generalised pustular psoriasis
0.000 0.177 0.823
D04.5 Skin of trunk
0.000 0.184 0.816
E78.1 Pure hyperglyceridaemia
0.000 0.186 0.814
D04.3 Skin of other and unspecified parts of face
0.000 0.186 0.814
E10.2 With renal complications
0.000 0.189 0.811
E11.2 With renal complications
0.000 0.193 0.807
G36 Other acute disseminated demyelination
0.802 0.197 0.000
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.199 0.801
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.201 0.799
C85.1 B-cell lymphoma, unspecified
0.000 0.205 0.795
C73 Malignant neoplasm of thyroid gland
0.000 0.208 0.792
M06.3 Rheumatoid nodule
0.000 0.208 0.792
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.213 0.787
E04 Other non-toxic goitre
0.000 0.218 0.782
E28 Ovarian dysfunction
0.000 0.218 0.782
E88 Other metabolic disorders
0.000 0.218 0.782
L40.0 Psoriasis vulgaris
0.000 0.226 0.774
E29 Testicular dysfunction
0.000 0.229 0.771
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.233 0.767
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.233 0.767
D37-D48 Neoplasms of uncertain or unknown behaviour
0.000 0.235 0.765
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.236 0.764
E06.3 Autoimmune thyroiditis
0.000 0.237 0.763
E23.0 Hypopituitarism
0.000 0.237 0.763
E13 Other specified diabetes mellitus
0.000 0.240 0.760
E26 Hyperaldosteronism
0.000 0.240 0.760
M06.4 Inflammatory polyarthropathy
0.000 0.240 0.760
E24 Cushing's syndrome
0.000 0.240 0.760
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.000 0.240 0.760
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.240 0.760
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.000 0.247 0.753
E84 Cystic fibrosis
0.000 0.249 0.751
C43 Malignant melanoma of skin
0.000 0.253 0.747
C91 Lymphoid leukaemia
0.000 0.254 0.746
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.257 0.743
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.260 0.740
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.261 0.739
D04.7 Skin of lower limb, including hip
0.000 0.262 0.738
L43.8 Other lichen planus
0.000 0.264 0.736
E11.1 With ketoacidosis
0.000 0.264 0.736
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.267 0.733
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.000 0.269 0.731
E10.8 With unspecified complications
0.000 0.270 0.730
L40.4 Guttate psoriasis
0.000 0.271 0.728
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.274 0.726
E79 Disorders of purine and pyrimidine metabolism
0.000 0.275 0.725
C82.0 Small cleaved cell, follicular
0.000 0.275 0.725
E11.8 With unspecified complications
0.000 0.275 0.725
D09 Carcinoma in situ of other and unspecified sites
0.000 0.280 0.720
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.280 0.720
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.000 0.282 0.718
L43.9 Lichen planus, unspecified
0.000 0.282 0.718
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
C44.8 Overlapping lesion of skin
0.000 0.283 0.717
M07.38 Other psoriatic arthropathies (Other)
0.000 0.283 0.717
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.283 0.717
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.283 0.717
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.283 0.717
M07.6 Other enteropathic arthropathies
0.000 0.283 0.717
M07.5 Arthropathy in ulcerative colitis
0.000 0.283 0.717
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.283 0.717
M07.2 Psoriatic spondylitis
0.000 0.283 0.717
M07.1 Arthritis mutilans
0.000 0.283 0.717
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
L40.3 Pustulosis palmaris et plantaris
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.284 0.716
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.284 0.716
M05.1 Rheumatoid lung disease
0.000 0.284 0.716
M05.0 Felty's syndrome
0.000 0.284 0.716
D04.2 Skin of ear and external auricular canal
0.000 0.284 0.716
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.284 0.716
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.284 0.716
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.284 0.716
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.284 0.716
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.284 0.716
D01 Carcinoma in situ of other and unspecified digestive organs
0.000 0.285 0.715
E89.4 Postprocedural ovarian failure
0.000 0.285 0.715
D04.4 Skin of scalp and neck
0.000 0.285 0.715
E77 Disorders of glycoprotein metabolism
0.000 0.286 0.714
E76 Disorders of glycosaminoglycan metabolism
0.000 0.286 0.714
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.286 0.714
E70 Disorders of aromatic amino-acid metabolism
0.000 0.286 0.714
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.286 0.714
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.288 0.712
E32 Diseases of thymus
0.000 0.288 0.712
E31 Polyglandular dysfunction
0.000 0.288 0.712
E30 Disorders of puberty, not elsewhere classified
0.000 0.288 0.712
L42 Pityriasis rosea
0.000 0.289 0.711
C43.3 Malignant melanoma of other and unspecified parts of face
0.000 0.289 0.711
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.290 0.710
E10.6 With other specified complications
0.000 0.291 0.709
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.291 0.709
E27.9 Disorder of adrenal gland, unspecified
0.000 0.293 0.707
G37.5 Concentric sclerosis [Balo]
0.706 0.294 0.000
G37.4 Subacute necrotising myelitis
0.706 0.294 0.000
G37.2 Central pontine myelinolysis
0.706 0.294 0.000
G37.1 Central demyelination of corpus callosum
0.706 0.294 0.000
G37.0 Diffuse sclerosis
0.706 0.294 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.294 0.706
E23.1 Drug-induced hypopituitarism
0.000 0.294 0.706
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.295 0.705
E05.8 Other thyrotoxicosis
0.000 0.295 0.705
D43.0 Brain, supratentorial
0.000 0.299 0.701
M10.9 Gout, unspecified
0.000 0.299 0.701
E11.0 With coma
0.000 0.299 0.700
E89.3 Postprocedural hypopituitarism
0.000 0.299 0.701
E04.0 Non-toxic diffuse goitre
0.000 0.302 0.698
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.304 0.696
E11.7 With multiple complications
0.000 0.304 0.696
D04.9 Skin, unspecified
0.000 0.305 0.695
C83.1 Small cleaved cell (diffuse)
0.000 0.307 0.693
C83.7 Burkitt's tumour
0.000 0.308 0.692
M06.8 Other specified rheumatoid arthritis
0.000 0.310 0.690
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.310 0.690
L44 Other papulosquamous disorders
0.000 0.311 0.689
L41 Parapsoriasis
0.000 0.311 0.689
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.311 0.689
M12 Other specific arthropathies
0.000 0.315 0.685
C02 Malignant neoplasm of other and unspecified parts of tongue
0.000 0.319 0.681
E03.1 Congenital hypothyroidism without goitre
0.000 0.319 0.681
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.000 0.319 0.681
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.320 0.680
E80.4 Gilbert's syndrome
0.000 0.320 0.680
E03.8 Other specified hypothyroidism
0.000 0.321 0.678
E27.8 Other specified disorders of adrenal gland
0.000 0.323 0.677
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.324 0.676
L57.5 Actinic granuloma
0.000 0.325 0.675
L57.3 Poikiloderma of Civatte
0.000 0.325 0.675
L57.2 Cutis rhomboidalis nuchae
0.000 0.325 0.675
L57.1 Actinic reticuloid
0.000 0.325 0.675
E85 Amyloidosis
0.000 0.325 0.675
E20 Hypoparathyroidism
0.000 0.327 0.673
G36.0 Neuromyelitis optica [Devic]
0.669 0.331 0.000
D03 Melanoma in situ
0.000 0.332 0.668
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.333 0.667
C82.2 Large cell, follicular
0.000 0.334 0.666
M10.0 Idiopathic gout
0.000 0.335 0.665
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.337 0.663
E27.5 Adrenomedullary hyperfunction
0.000 0.338 0.662
E27.0 Other adrenocortical overactivity
0.000 0.338 0.662
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.341 0.659
E89.5 Postprocedural testicular hypofunction
0.000 0.341 0.659
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.000 0.341 0.659
C84 Peripheral and cutaneous T-cell lymphomas
0.000 0.344 0.656
E25 Adrenogenital disorders
0.000 0.346 0.654
C91.9 Lymphoid leukaemia, unspecified
0.000 0.346 0.654
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.348 0.652
C94 Other leukaemias of specified cell type
0.000 0.348 0.652
L55 Sunburn
0.000 0.351 0.649
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.351 0.649
D46 Myelodysplastic syndromes
0.000 0.351 0.649
D02 Carcinoma in situ of middle ear and respiratory system
0.000 0.352 0.648
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.000 0.354 0.646
C85.0 Lymphosarcoma
0.000 0.354 0.646
E10.4 With neurological complications
0.000 0.355 0.645
D06.0 Endocervix
0.000 0.355 0.645
E78.4 Other hyperlipidaemia
0.000 0.357 0.643
D06.7 Other parts of cervix
0.000 0.358 0.642
D06.1 Exocervix
0.000 0.358 0.642
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.358 0.642
D04.8 Skin of other sites
0.000 0.359 0.641
D04.0 Skin of lip
0.000 0.359 0.641
C12 Malignant neoplasm of pyriform sinus
0.000 0.359 0.640
C83.6 Undifferentiated (diffuse)
0.000 0.360 0.640
C83.5 Lymphoblastic (diffuse)
0.000 0.360 0.640
C83.4 Immunoblastic (diffuse)
0.000 0.360 0.640
C83.2 Mixed small and large cell (diffuse)
0.000 0.360 0.640
E28.2 Polycystic ovarian syndrome
0.000 0.363 0.637
E88.8 Other specified metabolic disorders
0.000 0.365 0.635
E89.1 Postprocedural hypoinsulinaemia
0.000 0.365 0.635
E78.3 Hyperchylomicronaemia
0.000 0.365 0.634
C93 Monocytic leukaemia
0.000 0.367 0.633
M10.90 Gout, unspecified (Multiple sites)
0.000 0.367 0.633
E73 Lactose intolerance
0.000 0.369 0.631
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.369 0.631
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.369 0.631
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.369 0.631
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.369 0.631
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.369 0.631
M05.2 Rheumatoid vasculitis
0.000 0.371 0.629
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.372 0.628
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.372 0.627
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.374 0.626
C86 Other specified types of T/NK-cell lymphoma
0.000 0.376 0.624
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.000 0.377 0.623
E89.2 Postprocedural hypoparathyroidism
0.000 0.378 0.622
M11 Other crystal arthropathies
0.000 0.378 0.622
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.621 0.379 0.000
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.379 0.620
E04.9 Non-toxic goitre, unspecified
0.000 0.380 0.620
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.380 0.620
C07 Malignant neoplasm of parotid gland
0.000 0.380 0.620
L43.3 Subacute (active) lichen planus
0.000 0.383 0.617
L43.2 Lichenoid drug reaction
0.000 0.383 0.617
L43.1 Bullous lichen planus
0.000 0.383 0.617
L43.0 Hypertrophic lichen planus
0.000 0.383 0.617
E11.6 With other specified complications
0.000 0.384 0.616
E74 Other disorders of carbohydrate metabolism
0.000 0.386 0.614
E80.6 Other disorders of bilirubin metabolism
0.000 0.386 0.613
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.000 0.387 0.613
E29.1 Testicular hypofunction
0.000 0.389 0.611
E72 Other disorders of amino-acid metabolism
0.000 0.389 0.610
C88 Malignant immunoproliferative diseases
0.000 0.392 0.608
C03 Malignant neoplasm of gum
0.000 0.395 0.605
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.395 0.605
M10.4 Other secondary gout
0.000 0.396 0.604
M10.2 Drug-induced gout
0.000 0.396 0.604
M10.1 Lead-induced gout
0.000 0.396 0.604
L58 Radiodermatitis
0.000 0.399 0.601
C02.9 Tongue, unspecified
0.000 0.399 0.601
M06.34 Rheumatoid nodule (Hand)
0.000 0.404 0.596
E06.5 Other chronic thyroiditis
0.000 0.404 0.595
E06.4 Drug-induced thyroiditis
0.000 0.404 0.595
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.404 0.595
E06.0 Acute thyroiditis
0.000 0.404 0.595
C90 Multiple myeloma and malignant plasma cell neoplasms
0.000 0.405 0.595
D01.0 Colon
0.000 0.405 0.594
E88.2 Lipomatosis, not elsewhere classified
0.000 0.406 0.594
E26.0 Primary hyperaldosteronism
0.000 0.407 0.593
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.407 0.592
E88.9 Metabolic disorder, unspecified
0.000 0.408 0.592
D47.1 Chronic myeloproliferative disease
0.000 0.409 0.591
C82.6 Cutaneous follicle centre lymphoma
0.000 0.409 0.590
C82.5 Diffuse follicle centre lymphoma
0.000 0.409 0.590
C82.4 Follicular lymphoma grade IIIb
0.000 0.409 0.590
C08 Malignant neoplasm of other and unspecified major salivary glands
0.000 0.411 0.589
E80.1 Porphyria cutanea tarda
0.000 0.411 0.589
E13.9 Without complications
0.000 0.412 0.588
L56.9 Acute skin change due to ultraviolet radiation, unspecified
0.000 0.412 0.588
M10.3 Gout due to impairment of renal function
0.000 0.414 0.586
C95 Leukaemia of unspecified cell type
0.000 0.414 0.586
C02.1 Border of tongue
0.000 0.415 0.585
C91.5 Adult T-cell leukaemia
0.000 0.417 0.582
L10-L14 Bullous disorders
0.000 0.419 0.581
E24.0 Pituitary-dependent Cushing's disease
0.000 0.419 0.581
C82.1 Mixed small cleaved and large cell, follicular
0.000 0.421 0.578
D04.6 Skin of upper limb, including shoulder
0.000 0.423 0.577
E84.9 Cystic fibrosis, unspecified
0.000 0.424 0.575
G36.9 Acute disseminated demyelination, unspecified
0.575 0.424 0.000
G36.8 Other specified acute disseminated demyelination
0.575 0.424 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.575 0.424 0.000
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.427 0.573
E80.5 Crigler-Najjar syndrome
0.000 0.427 0.573
E80.3 Defects of catalase and peroxydase
0.000 0.427 0.573
E80.0 Hereditary erythropoietic porphyria
0.000 0.427 0.573
D09.0 Bladder
0.000 0.428 0.572
C13 Malignant neoplasm of hypopharynx
0.000 0.428 0.572
E06.9 Thyroiditis, unspecified
0.000 0.428 0.572
D47.2 Monoclonal gammopathy
0.000 0.428 0.572
C04 Malignant neoplasm of floor of mouth
0.000 0.429 0.571
D00.1 Oesophagus
0.000 0.430 0.570
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.430 0.570
C11 Malignant neoplasm of nasopharynx
0.000 0.430 0.570
E04.2 Non-toxic multinodular goitre
0.000 0.431 0.569
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.432 0.568
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.432 0.568
M06.38 Rheumatoid nodule (Other)
0.000 0.432 0.568
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.432 0.568
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.432 0.568
M06.33 Rheumatoid nodule (Forearm)
0.000 0.432 0.568
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.432 0.568
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.432 0.568
C91.4 Hairy-cell leukaemia
0.000 0.432 0.568
C43.6 Malignant melanoma of upper limb, including shoulder
0.000 0.433 0.567
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.435 0.564
L57.4 Cutis laxa senilis
0.000 0.436 0.564
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.000 0.436 0.564
C82.3 Follicular lymphoma grade IIIa
0.000 0.437 0.563
E04.8 Other specified non-toxic goitre
0.000 0.439 0.561
E28.9 Ovarian dysfunction, unspecified
0.000 0.440 0.560
E28.8 Other ovarian dysfunction
0.000 0.440 0.560
E28.1 Androgen excess
0.000 0.440 0.560
E28.0 Oestrogen excess
0.000 0.440 0.560
E88.3 Tumour lysis syndrome
0.000 0.440 0.560
D04.1 Skin of eyelid, including canthus
0.000 0.440 0.560
C75 Malignant neoplasm of other endocrine glands and related structures
0.000 0.440 0.560
C81 Hodgkin's disease
0.000 0.442 0.558
E24.9 Cushing's syndrome, unspecified
0.000 0.442 0.558
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
0.000 0.442 0.558
M14 Arthropathies in other diseases classified elsewhere
0.000 0.442 0.557
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.444 0.556
E78.8 Other disorders of lipoprotein metabolism
0.000 0.446 0.554
D03.5 Melanoma in situ of trunk
0.000 0.447 0.553
E29.9 Testicular dysfunction, unspecified
0.000 0.447 0.553
E29.8 Other testicular dysfunction
0.000 0.447 0.553
E29.0 Testicular hyperfunction
0.000 0.447 0.553
D43.2 Brain, unspecified
0.000 0.448 0.552
M10.94 Gout, unspecified (Hand)
0.000 0.449 0.551
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.000 0.449 0.551
C44.5 Skin of trunk
0.000 0.449 0.551
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.000 0.451 0.549
D43.4 Spinal cord
0.000 0.451 0.549
E28.3 Primary ovarian failure
0.000 0.451 0.549
C91.0 Acute lymphoblastic leukaemia
0.000 0.452 0.548
E24.2 Drug-induced Cushing's syndrome
0.000 0.454 0.546
E13.8 With unspecified complications
0.000 0.455 0.545
E13.7 With multiple complications
0.000 0.455 0.545
E13.6 With other specified complications
0.000 0.455 0.545
E13.5 With peripheral circulatory complications
0.000 0.455 0.545
E13.4 With neurological complications
0.000 0.455 0.545
E13.3 With ophthalmic complications
0.000 0.455 0.545
E13.2 With renal complications
0.000 0.455 0.545
E13.1 With ketoacidosis
0.000 0.455 0.545
E13.0 With coma
0.000 0.455 0.545
E26.9 Hyperaldosteronism, unspecified
0.000 0.455 0.545
E26.8 Other hyperaldosteronism
0.000 0.455 0.545
E26.1 Secondary hyperaldosteronism
0.000 0.455 0.545
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.455 0.545
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.455 0.545
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.455 0.545
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.455 0.545
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.455 0.545
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.455 0.545
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.455 0.545
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.455 0.545
E24.8 Other Cushing's syndrome
0.000 0.455 0.545
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.455 0.545
E24.3 Ectopic ACTH syndrome
0.000 0.455 0.545
E24.1 Nelson's syndrome
0.000 0.455 0.545
E83 Disorders of mineral metabolism
0.065 0.457 0.478
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.460 0.540
E11.5 With peripheral circulatory complications
0.000 0.460 0.540
M10.09 Idiopathic gout (Site unspecified)
0.000 0.461 0.539
E84.8 Cystic fibrosis with other manifestations
0.000 0.461 0.539
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.461 0.539
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.461 0.539
C84.5 Other and unspecified T-cell lymphomas
0.000 0.462 0.538
C43.7 Malignant melanoma of lower limb, including hip
0.000 0.462 0.538
L82 Seborrhoeic keratosis
0.000 0.463 0.537
C43.8 Overlapping malignant melanoma of skin
0.000 0.464 0.536
C43.0 Malignant melanoma of lip
0.000 0.464 0.536
D09.1 Other and unspecified urinary organs
0.000 0.465 0.535
C91.8 Mature B-cell leukaemia Burkitt-type
0.000 0.465 0.535
C91.7 Other lymphoid leukaemia
0.000 0.465 0.535
C91.6 Prolymphocytic leukaemia of T-cell type
0.000 0.465 0.535
C91.3 Prolymphocytic leukaemia
0.000 0.465 0.535
C91.2 Subacute lymphocytic leukaemia
0.000 0.465 0.535
D46.2 Refractory anaemia with excess of blasts
0.000 0.467 0.533
C43.4 Malignant melanoma of scalp and neck
0.000 0.468 0.532
D00.0 Lip, oral cavity and pharynx
0.000 0.468 0.532
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.000 0.469 0.531
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.469 0.531
C43.2 Malignant melanoma of ear and external auricular canal
0.000 0.469 0.531
C83.8 Other types of diffuse non-Hodgkin's lymphoma
0.000 0.469 0.530
D43.9 Central nervous system, unspecified
0.000 0.476 0.524
D43.7 Other parts of central nervous system
0.000 0.476 0.524
D43.3 Cranial nerves
0.000 0.476 0.524
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.000 0.477 0.523
M10.96 Gout, unspecified (Lower leg)
0.000 0.479 0.521
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.480 0.520
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.480 0.520
E79.1 Lesch-Nyhan syndrome
0.000 0.480 0.520
C74 Malignant neoplasm of adrenal gland
0.000 0.481 0.519
C00 Malignant neoplasm of lip
0.000 0.481 0.519
E21.3 Hyperparathyroidism, unspecified
0.000 0.482 0.518
D01.3 Anus and anal canal
0.000 0.483 0.517
D09.9 Carcinoma in situ, unspecified
0.000 0.484 0.516
D09.7 Carcinoma in situ of other specified sites
0.000 0.484 0.516
D09.3 Thyroid and other endocrine glands
0.000 0.484 0.516
D09.2 Eye
0.000 0.484 0.516
D40.0 Prostate
0.000 0.484 0.516
E21.4 Other specified disorders of parathyroid gland
0.000 0.484 0.516
E85.9 Amyloidosis, unspecified
0.000 0.484 0.516
D00.2 Stomach
0.000 0.485 0.515
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
M08.9 Juvenile arthritis, unspecified
0.000 0.486 0.514
M08.8 Other juvenile arthritis
0.000 0.486 0.514
M08.4 Pauciarticular juvenile arthritis
0.000 0.486 0.514
M08.3 Juvenile polyarthritis (seronegative)
0.000 0.486 0.514
M08.2 Juvenile arthritis with systemic onset
0.000 0.486 0.514
M08.1 Juvenile ankylosing spondylitis
0.000 0.486 0.514
M08.0 Juvenile rheumatoid arthritis
0.000 0.486 0.514
M09.8 Juvenile arthritis in other diseases classified elsewhere
0.000 0.486 0.514
M09.2 Juvenile arthritis in ulcerative colitis
0.000 0.486 0.514
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]
0.000 0.486 0.514
M09.0 Juvenile arthritis in psoriasis
0.000 0.486 0.514
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.486 0.514
M06.18 Adult-onset Still's disease (Other)
0.000 0.486 0.514
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.486 0.514
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.486 0.514
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.486 0.514
M06.14 Adult-onset Still's disease (Hand)
0.000 0.486 0.514
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.486 0.514
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.486 0.514
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.486 0.514
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.486 0.514
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.486 0.514
M06.28 Rheumatoid bursitis (Other)
0.000 0.486 0.514

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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