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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2857198
log Bayes Factor = 50.434
Chromosome 6   position 32,746,920  (GRCh37) Explore rs2857198 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
M07.3 Other psoriatic arthropathies
0.000 0.000 1.000
C44 Other malignant neoplasms of skin
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
M07 Psoriatic and enteropathic arthropathies
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
L57.0 Actinic keratosis
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.001 0.999
C44.7 Skin of lower limb, including hip
0.000 0.001 0.999
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.001 0.999
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.003 0.997
L40.9 Psoriasis, unspecified
0.000 0.003 0.997
E05.9 Thyrotoxicosis, unspecified
0.000 0.003 0.997
C44.3 Skin of other and unspecified parts of face
0.000 0.004 0.996
E10.3 With ophthalmic complications
0.000 0.004 0.996
E20-E35 Disorders of other endocrine glands
0.000 0.004 0.996
C44.6 Skin of upper limb, including shoulder
0.000 0.004 0.996
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.007 0.993
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.007 0.993
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.008 0.992
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.010 0.990
E23 Hypofunction and other disorders of pituitary gland
0.000 0.011 0.989
E83.1 Disorders of iron metabolism
0.987 0.013 0.000
E10.9 Without complications
0.000 0.013 0.987
G35-G37 Demyelinating diseases of the central nervous system
0.986 0.014 0.000
E70-E90 Metabolic disorders
0.000 0.018 0.982
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.018 0.982
G37 Other demyelinating diseases of central nervous system
0.981 0.019 0.000
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.020 0.980
G37.9 Demyelinating disease of central nervous system, unspecified
0.973 0.027 0.000
L40-L45 Papulosquamous disorders
0.000 0.028 0.972
E78.0 Pure hypercholesterolaemia
0.000 0.031 0.969
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.041 0.959
E11 Non-insulin-dependent diabetes mellitus
0.000 0.042 0.958
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.066 0.934
E23.6 Other disorders of pituitary gland
0.000 0.069 0.931
E23.7 Disorder of pituitary gland, unspecified
0.000 0.074 0.926
C43-C44 Melanoma and other malignant neoplasms of skin
0.000 0.075 0.925
C44.2 Skin of ear and external auricular canal
0.000 0.075 0.925
C44.4 Skin of scalp and neck
0.000 0.078 0.922
E27 Other disorders of adrenal gland
0.000 0.082 0.918
E11.3 With ophthalmic complications
0.000 0.084 0.916
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.085 0.915
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.090 0.910
E78.5 Hyperlipidaemia, unspecified
0.000 0.096 0.904
E10.5 With peripheral circulatory complications
0.000 0.097 0.903
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.105 0.895
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.114 0.886
C44.0 Skin of lip
0.000 0.119 0.881
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.120 0.880
E11.9 Without complications
0.000 0.123 0.877
G37.8 Other specified demyelinating diseases of central nervous system
0.875 0.125 0.000
E06 Thyroiditis
0.000 0.130 0.870
D00-D09 In situ neoplasms
0.000 0.131 0.869
L43 Lichen planus
0.000 0.132 0.868
Chapter II Neoplasms
0.000 0.133 0.867
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.000 0.133 0.867
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.000 0.141 0.859
D04 Carcinoma in situ of skin
0.000 0.142 0.858
D06 Carcinoma in situ of cervix uteri
0.000 0.146 0.854
E27.1 Primary adrenocortical insufficiency
0.000 0.149 0.851
M06.0 Seronegative rheumatoid arthritis
0.000 0.150 0.850
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.000 0.150 0.850
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.152 0.848
D06.9 Cervix, unspecified
0.000 0.157 0.843
E89.0 Postprocedural hypothyroidism
0.000 0.157 0.843
E10.1 With ketoacidosis
0.000 0.157 0.843
E23.2 Diabetes insipidus
0.000 0.158 0.842
E04 Other non-toxic goitre
0.000 0.161 0.839
E10.0 With coma
0.000 0.161 0.839
E78.2 Mixed hyperlipidaemia
0.000 0.163 0.837
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.165 0.835
C83 Diffuse non-Hodgkin's lymphoma
0.000 0.170 0.830
E78.6 Lipoprotein deficiency
0.000 0.171 0.829
L40.1 Generalised pustular psoriasis
0.000 0.175 0.825
E28 Ovarian dysfunction
0.000 0.186 0.814
E06.3 Autoimmune thyroiditis
0.000 0.187 0.813
M10 Gout
0.000 0.187 0.813
C83.3 Large cell (diffuse)
0.000 0.187 0.813
E78.1 Pure hyperglyceridaemia
0.000 0.192 0.807
L40.0 Psoriasis vulgaris
0.000 0.197 0.803
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.198 0.802
M06.3 Rheumatoid nodule
0.000 0.198 0.802
D37-D48 Neoplasms of uncertain or unknown behaviour
0.000 0.201 0.799
G36 Other acute disseminated demyelination
0.799 0.201 0.000
E88 Other metabolic disorders
0.000 0.211 0.789
D04.5 Skin of trunk
0.000 0.212 0.788
E10.2 With renal complications
0.000 0.214 0.786
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.214 0.786
E29 Testicular dysfunction
0.000 0.214 0.786
E23.0 Hypopituitarism
0.000 0.217 0.783
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.000 0.222 0.778
E11.2 With renal complications
0.000 0.225 0.775
D04.3 Skin of other and unspecified parts of face
0.000 0.226 0.774
E13 Other specified diabetes mellitus
0.000 0.227 0.773
E24 Cushing's syndrome
0.000 0.228 0.772
M06.4 Inflammatory polyarthropathy
0.000 0.231 0.769
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.233 0.767
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.000 0.233 0.767
C85.1 B-cell lymphoma, unspecified
0.000 0.242 0.758
E04.0 Non-toxic diffuse goitre
0.000 0.248 0.752
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.250 0.750
E05.8 Other thyrotoxicosis
0.000 0.253 0.747
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.253 0.747
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.256 0.744
E84 Cystic fibrosis
0.000 0.258 0.742
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.259 0.741
E26 Hyperaldosteronism
0.000 0.260 0.740
E11.1 With ketoacidosis
0.000 0.262 0.738
D04.7 Skin of lower limb, including hip
0.000 0.263 0.737
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.263 0.737
D43.0 Brain, supratentorial
0.000 0.264 0.736
L43.9 Lichen planus, unspecified
0.000 0.264 0.736
E10.8 With unspecified complications
0.000 0.265 0.735
C73 Malignant neoplasm of thyroid gland
0.000 0.265 0.735
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.000 0.265 0.735
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.265 0.734
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.000 0.267 0.733
L40.4 Guttate psoriasis
0.000 0.270 0.730
L43.8 Other lichen planus
0.000 0.271 0.729
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.274 0.726
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.274 0.726
E89.3 Postprocedural hypopituitarism
0.000 0.275 0.725
L42 Pityriasis rosea
0.000 0.276 0.724
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
M07.38 Other psoriatic arthropathies (Other)
0.000 0.283 0.717
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.283 0.717
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.283 0.717
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.283 0.717
C44.8 Overlapping lesion of skin
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
M07.6 Other enteropathic arthropathies
0.000 0.283 0.717
M07.5 Arthropathy in ulcerative colitis
0.000 0.283 0.717
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.283 0.717
M07.2 Psoriatic spondylitis
0.000 0.283 0.717
M07.1 Arthritis mutilans
0.000 0.283 0.717
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.283 0.717
E79 Disorders of purine and pyrimidine metabolism
0.000 0.283 0.717
L40.3 Pustulosis palmaris et plantaris
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.284 0.716
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.284 0.716
M05.1 Rheumatoid lung disease
0.000 0.284 0.716
M05.0 Felty's syndrome
0.000 0.284 0.716
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.284 0.716
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.284 0.716
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.284 0.716
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.284 0.716
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.284 0.716
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.000 0.285 0.715
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.286 0.714
E32 Diseases of thymus
0.000 0.286 0.714
E31 Polyglandular dysfunction
0.000 0.286 0.714
E30 Disorders of puberty, not elsewhere classified
0.000 0.286 0.714
E10.6 With other specified complications
0.000 0.287 0.713
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.287 0.713
D09 Carcinoma in situ of other and unspecified sites
0.000 0.287 0.713
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.288 0.712
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.289 0.711
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.291 0.709
E23.1 Drug-induced hypopituitarism
0.000 0.291 0.709
E77 Disorders of glycoprotein metabolism
0.000 0.296 0.704
E76 Disorders of glycosaminoglycan metabolism
0.000 0.296 0.704
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.296 0.704
E70 Disorders of aromatic amino-acid metabolism
0.000 0.296 0.704
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.296 0.704
C91 Lymphoid leukaemia
0.000 0.296 0.704
G37.5 Concentric sclerosis [Balo]
0.703 0.296 0.000
G37.4 Subacute necrotising myelitis
0.703 0.296 0.000
G37.2 Central pontine myelinolysis
0.703 0.296 0.000
G37.1 Central demyelination of corpus callosum
0.703 0.296 0.000
G37.0 Diffuse sclerosis
0.703 0.296 0.000
E11.0 With coma
0.000 0.300 0.700
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.301 0.699
L44 Other papulosquamous disorders
0.000 0.303 0.697
L41 Parapsoriasis
0.000 0.303 0.697
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.303 0.697
E11.8 With unspecified complications
0.000 0.303 0.696
D46 Myelodysplastic syndromes
0.000 0.305 0.695
M06.8 Other specified rheumatoid arthritis
0.000 0.309 0.691
D04.2 Skin of ear and external auricular canal
0.000 0.309 0.691
D04.4 Skin of scalp and neck
0.000 0.309 0.691
D01 Carcinoma in situ of other and unspecified digestive organs
0.000 0.312 0.688
E03.8 Other specified hypothyroidism
0.000 0.312 0.688
L57.5 Actinic granuloma
0.000 0.313 0.687
L57.3 Poikiloderma of Civatte
0.000 0.313 0.687
L57.2 Cutis rhomboidalis nuchae
0.000 0.313 0.687
L57.1 Actinic reticuloid
0.000 0.313 0.687
E28.2 Polycystic ovarian syndrome
0.000 0.313 0.687
E11.7 With multiple complications
0.000 0.313 0.687
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.314 0.686
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.000 0.315 0.685
C43 Malignant melanoma of skin
0.000 0.315 0.685
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.317 0.682
E03.1 Congenital hypothyroidism without goitre
0.000 0.318 0.682
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.319 0.681
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.319 0.681
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.319 0.681
E20 Hypoparathyroidism
0.000 0.321 0.678
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.322 0.678
E27.9 Disorder of adrenal gland, unspecified
0.000 0.323 0.677
E04.9 Non-toxic goitre, unspecified
0.000 0.324 0.676
E89.4 Postprocedural ovarian failure
0.000 0.324 0.676
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.326 0.674
L82 Seborrhoeic keratosis
0.000 0.330 0.670
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.000 0.330 0.670
L55 Sunburn
0.000 0.331 0.669
D04.9 Skin, unspecified
0.000 0.331 0.669
M12 Other specific arthropathies
0.000 0.333 0.667
E10.4 With neurological complications
0.000 0.335 0.665
G36.0 Neuromyelitis optica [Devic]
0.665 0.335 0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.000 0.336 0.664
E04.2 Non-toxic multinodular goitre
0.000 0.341 0.659
E27.5 Adrenomedullary hyperfunction
0.000 0.342 0.658
E27.0 Other adrenocortical overactivity
0.000 0.342 0.658
E25 Adrenogenital disorders
0.000 0.343 0.657
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.344 0.656
E78.4 Other hyperlipidaemia
0.000 0.346 0.654
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.347 0.653
E89.5 Postprocedural testicular hypofunction
0.000 0.347 0.653
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.348 0.652
C43.3 Malignant melanoma of other and unspecified parts of face
0.000 0.351 0.649
C82.0 Small cleaved cell, follicular
0.000 0.351 0.649
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.649 0.351 0.000
C83.1 Small cleaved cell (diffuse)
0.000 0.352 0.648
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.354 0.646
M10.0 Idiopathic gout
0.000 0.354 0.646
C83.7 Burkitt's tumour
0.000 0.355 0.645
E88.8 Other specified metabolic disorders
0.000 0.357 0.643
M10.9 Gout, unspecified
0.000 0.359 0.641
C02 Malignant neoplasm of other and unspecified parts of tongue
0.000 0.360 0.640
D47.2 Monoclonal gammopathy
0.000 0.362 0.638
C84 Peripheral and cutaneous T-cell lymphomas
0.000 0.364 0.636
E29.1 Testicular hypofunction
0.000 0.365 0.635
D47.1 Chronic myeloproliferative disease
0.000 0.366 0.634
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.366 0.634
E89.1 Postprocedural hypoinsulinaemia
0.000 0.370 0.630
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.370 0.630
M05.2 Rheumatoid vasculitis
0.000 0.370 0.630
E89.2 Postprocedural hypoparathyroidism
0.000 0.373 0.627
E78.3 Hyperchylomicronaemia
0.000 0.374 0.626
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.375 0.625
D02 Carcinoma in situ of middle ear and respiratory system
0.000 0.376 0.624
L56.9 Acute skin change due to ultraviolet radiation, unspecified
0.000 0.376 0.624
E06.5 Other chronic thyroiditis
0.000 0.376 0.623
E06.4 Drug-induced thyroiditis
0.000 0.376 0.623
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.376 0.623
E06.0 Acute thyroiditis
0.000 0.376 0.623
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.377 0.622
L43.3 Subacute (active) lichen planus
0.000 0.378 0.622
L43.2 Lichenoid drug reaction
0.000 0.378 0.622
L43.1 Bullous lichen planus
0.000 0.378 0.622
L43.0 Hypertrophic lichen planus
0.000 0.378 0.622
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.378 0.622
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.379 0.621
C94 Other leukaemias of specified cell type
0.000 0.379 0.621
M11 Other crystal arthropathies
0.000 0.379 0.621
E06.9 Thyroiditis, unspecified
0.000 0.380 0.620
C91.9 Lymphoid leukaemia, unspecified
0.000 0.381 0.619
E11.6 With other specified complications
0.000 0.381 0.619
D06.0 Endocervix
0.000 0.382 0.618
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.000 0.384 0.616
C85.0 Lymphosarcoma
0.000 0.384 0.616
D04.8 Skin of other sites
0.000 0.384 0.615
D04.0 Skin of lip
0.000 0.384 0.615
L85 Other epidermal thickening
0.000 0.386 0.614
L58 Radiodermatitis
0.000 0.386 0.614
D06.7 Other parts of cervix
0.000 0.388 0.612
D06.1 Exocervix
0.000 0.388 0.612
E27.8 Other specified disorders of adrenal gland
0.000 0.389 0.611
E13.9 Without complications
0.000 0.390 0.610
M06.34 Rheumatoid nodule (Hand)
0.000 0.390 0.610
E74 Other disorders of carbohydrate metabolism
0.000 0.390 0.610
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.390 0.610
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.390 0.610
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.390 0.610
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.390 0.610
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.390 0.610
D03 Melanoma in situ
0.000 0.391 0.609
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.392 0.608
E73 Lactose intolerance
0.000 0.394 0.606
C86 Other specified types of T/NK-cell lymphoma
0.000 0.394 0.606
C93 Monocytic leukaemia
0.000 0.395 0.605
C12 Malignant neoplasm of pyriform sinus
0.000 0.395 0.605
E21.3 Hyperparathyroidism, unspecified
0.000 0.396 0.604
E72 Other disorders of amino-acid metabolism
0.000 0.396 0.603
E88.2 Lipomatosis, not elsewhere classified
0.000 0.397 0.603
E04.8 Other specified non-toxic goitre
0.000 0.398 0.602
E80.4 Gilbert's syndrome
0.000 0.398 0.602
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.400 0.600
E88.9 Metabolic disorder, unspecified
0.000 0.401 0.599
C88 Malignant immunoproliferative diseases
0.000 0.401 0.598
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.402 0.598
L94 Other localised connective tissue disorders
0.000 0.403 0.597
C83.6 Undifferentiated (diffuse)
0.000 0.405 0.595
C83.5 Lymphoblastic (diffuse)
0.000 0.405 0.595
C83.4 Immunoblastic (diffuse)
0.000 0.405 0.595
C83.2 Mixed small and large cell (diffuse)
0.000 0.405 0.595
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.000 0.406 0.594
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.000 0.408 0.592
E24.0 Pituitary-dependent Cushing's disease
0.000 0.408 0.592
E85 Amyloidosis
0.000 0.411 0.589
D43.2 Brain, unspecified
0.000 0.411 0.589
C07 Malignant neoplasm of parotid gland
0.000 0.412 0.588
L85.8 Other specified epidermal thickening
0.000 0.412 0.588
L10-L14 Bullous disorders
0.000 0.414 0.586
C95 Leukaemia of unspecified cell type
0.000 0.415 0.585
E28.9 Ovarian dysfunction, unspecified
0.000 0.416 0.583
E28.8 Other ovarian dysfunction
0.000 0.416 0.583
E28.1 Androgen excess
0.000 0.416 0.583
E28.0 Oestrogen excess
0.000 0.416 0.583
M10.4 Other secondary gout
0.000 0.417 0.583
M10.2 Drug-induced gout
0.000 0.417 0.583
M10.1 Lead-induced gout
0.000 0.417 0.583
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.420 0.580
D09.0 Bladder
0.000 0.420 0.580
D43.4 Spinal cord
0.000 0.423 0.577
E28.3 Primary ovarian failure
0.000 0.424 0.576
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.425 0.575
M06.38 Rheumatoid nodule (Other)
0.000 0.425 0.575
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.425 0.575
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.425 0.575
M06.33 Rheumatoid nodule (Forearm)
0.000 0.425 0.575
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.425 0.575
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.425 0.575
E24.9 Cushing's syndrome, unspecified
0.000 0.426 0.574
D01.0 Colon
0.000 0.427 0.573
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.000 0.427 0.573
G36.9 Acute disseminated demyelination, unspecified
0.573 0.427 0.000
G36.8 Other specified acute disseminated demyelination
0.573 0.427 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.573 0.427 0.000
D46.2 Refractory anaemia with excess of blasts
0.000 0.427 0.573
C90 Multiple myeloma and malignant plasma cell neoplasms
0.000 0.428 0.572
E21.0 Primary hyperparathyroidism
0.000 0.428 0.572
C82.2 Large cell, follicular
0.000 0.429 0.571
C03 Malignant neoplasm of gum
0.000 0.429 0.571
E84.9 Cystic fibrosis, unspecified
0.000 0.430 0.570
C02.9 Tongue, unspecified
0.000 0.431 0.569
D46.9 Myelodysplastic syndrome, unspecified
0.000 0.431 0.569
L57.4 Cutis laxa senilis
0.000 0.432 0.567
M10.3 Gout due to impairment of renal function
0.000 0.434 0.566
M14 Arthropathies in other diseases classified elsewhere
0.000 0.434 0.566
E88.3 Tumour lysis syndrome
0.000 0.434 0.566
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.435 0.565
E21.4 Other specified disorders of parathyroid gland
0.000 0.436 0.564
E29.9 Testicular dysfunction, unspecified
0.000 0.437 0.563
E29.8 Other testicular dysfunction
0.000 0.437 0.563
E29.0 Testicular hyperfunction
0.000 0.437 0.563
M10.90 Gout, unspecified (Multiple sites)
0.000 0.440 0.560
E78.8 Other disorders of lipoprotein metabolism
0.000 0.440 0.560
L92 Granulomatous disorders of skin and subcutaneous tissue
0.000 0.442 0.558
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.000 0.443 0.557
E24.2 Drug-induced Cushing's syndrome
0.000 0.443 0.557
E11.5 With peripheral circulatory complications
0.000 0.443 0.557
E26.0 Primary hyperaldosteronism
0.000 0.444 0.556
C08 Malignant neoplasm of other and unspecified major salivary glands
0.000 0.444 0.556
E13.8 With unspecified complications
0.000 0.446 0.554
E13.7 With multiple complications
0.000 0.446 0.554
E13.6 With other specified complications
0.000 0.446 0.554
E13.5 With peripheral circulatory complications
0.000 0.446 0.554
E13.4 With neurological complications
0.000 0.446 0.554
E13.3 With ophthalmic complications
0.000 0.446 0.554
E13.2 With renal complications
0.000 0.446 0.554
E13.1 With ketoacidosis
0.000 0.446 0.554
E13.0 With coma
0.000 0.446 0.554
E24.8 Other Cushing's syndrome
0.000 0.446 0.554
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.446 0.554
E24.3 Ectopic ACTH syndrome
0.000 0.446 0.554
E24.1 Nelson's syndrome
0.000 0.446 0.554
C02.1 Border of tongue
0.000 0.447 0.553
C81 Hodgkin's disease
0.000 0.447 0.553
D40.0 Prostate
0.000 0.448 0.552
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.449 0.551
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.449 0.551
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.449 0.551
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.449 0.551
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.449 0.551
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.449 0.551
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.449 0.551
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.449 0.551
C91.5 Adult T-cell leukaemia
0.000 0.449 0.551
D43.9 Central nervous system, unspecified
0.000 0.450 0.550
D43.7 Other parts of central nervous system
0.000 0.450 0.550
D43.3 Cranial nerves
0.000 0.450 0.550
E21.2 Other hyperparathyroidism
0.000 0.450 0.550
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.454 0.546
L56.8 Other specified acute skin changes due to ultraviolet radiation
0.000 0.454 0.546
D09.1 Other and unspecified urinary organs
0.000 0.457 0.543
D04.6 Skin of upper limb, including shoulder
0.000 0.457 0.543
E80.1 Porphyria cutanea tarda
0.000 0.458 0.542
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.000 0.458 0.542
D48.5 Skin
0.000 0.458 0.542
C91.4 Hairy-cell leukaemia
0.000 0.460 0.540
D04.1 Skin of eyelid, including canthus
0.000 0.460 0.540
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.461 0.539
D43.1 Brain, infratentorial
0.000 0.461 0.538
E80.6 Other disorders of bilirubin metabolism
0.000 0.462 0.538
C11 Malignant neoplasm of nasopharynx
0.000 0.463 0.537
D47.9 Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
0.000 0.463 0.537
L56.3 Solar urticaria
0.000 0.464 0.535
L56.2 Photocontact dermatitis [berloque dermatitis]
0.000 0.464 0.535
L56.1 Drug photoallergic response
0.000 0.464 0.535
L56.0 Drug phototoxic response
0.000 0.464 0.535
D47.3 Essential (haemorrhagic) thrombocythaemia
0.000 0.466 0.534
D00.1 Oesophagus
0.000 0.466 0.533
E84.8 Cystic fibrosis with other manifestations
0.000 0.468 0.532
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.468 0.532
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.468 0.532
E26.9 Hyperaldosteronism, unspecified
0.000 0.469 0.530
E26.8 Other hyperaldosteronism
0.000 0.469 0.530
E26.1 Secondary hyperaldosteronism
0.000 0.469 0.530
M13 Other arthritis
0.000 0.472 0.528
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
0.000 0.472 0.528
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.000 0.472 0.527
C82.6 Cutaneous follicle centre lymphoma
0.000 0.473 0.527
C82.5 Diffuse follicle centre lymphoma
0.000 0.473 0.527
C82.4 Follicular lymphoma grade IIIb
0.000 0.473 0.527
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.473 0.527
E80.5 Crigler-Najjar syndrome
0.000 0.473 0.527
E80.3 Defects of catalase and peroxydase
0.000 0.473 0.527
E80.0 Hereditary erythropoietic porphyria
0.000 0.473 0.527
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.473 0.526
C75 Malignant neoplasm of other endocrine glands and related structures
0.000 0.473 0.526
D47.7 Other specified neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.000 0.475 0.525
D47.5 Chronic eosinophilic leukaemia [hypereosinophilic syndrome]
0.000 0.475 0.525
D47.0 Histiocytic and mast cell tumours of uncertain and unknown behaviour
0.000 0.475 0.525
C84.5 Other and unspecified T-cell lymphomas
0.000 0.475 0.525
M10.09 Idiopathic gout (Site unspecified)
0.000 0.475 0.525
L94.2 Calcinosis cutis
0.000 0.476 0.524
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.000 0.478 0.522
E40-E46 Malnutrition
0.000 0.478 0.522
C91.0 Acute lymphoblastic leukaemia
0.000 0.478 0.522
D46.7 Other myelodysplastic syndromes
0.000 0.480 0.520
C82.1 Mixed small cleaved and large cell, follicular
0.000 0.480 0.520
C04 Malignant neoplasm of floor of mouth
0.000 0.480 0.519
C13 Malignant neoplasm of hypopharynx
0.000 0.484 0.516
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
M08.9 Juvenile arthritis, unspecified
0.000 0.486 0.514
M08.8 Other juvenile arthritis
0.000 0.486 0.514
M08.4 Pauciarticular juvenile arthritis
0.000 0.486 0.514
M08.3 Juvenile polyarthritis (seronegative)
0.000 0.486 0.514
M08.2 Juvenile arthritis with systemic onset
0.000 0.486 0.514
M08.1 Juvenile ankylosing spondylitis
0.000 0.486 0.514
M08.0 Juvenile rheumatoid arthritis
0.000 0.486 0.514
M09.8 Juvenile arthritis in other diseases classified elsewhere
0.000 0.486 0.514
M09.2 Juvenile arthritis in ulcerative colitis
0.000 0.486 0.514
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]
0.000 0.486 0.514
M09.0 Juvenile arthritis in psoriasis
0.000 0.486 0.514
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.486 0.514
M06.18 Adult-onset Still's disease (Other)
0.000 0.486 0.514
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.486 0.514
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.486 0.514
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.486 0.514
M06.14 Adult-onset Still's disease (Hand)
0.000 0.486 0.514
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.486 0.514
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.486 0.514
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.486 0.514
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.486 0.514
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.486 0.514
M06.28 Rheumatoid bursitis (Other)
0.000 0.486 0.514
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.486 0.514
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.486 0.514
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.486 0.514
M06.24 Rheumatoid bursitis (Hand)
0.000 0.486 0.514
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.486 0.514
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.486 0.514
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.486 0.514
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.486 0.514

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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