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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2857602
log Bayes Factor = 89.4881
Chromosome 6   position 31,533,378  (GRCh37) Explore rs2857602 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
I20.9 Angina pectoris, unspecified
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.001 0.999
E10.1 With ketoacidosis
0.000 0.001 0.999
E10.4 With neurological complications
0.000 0.002 0.998
I20.0 Unstable angina
0.000 0.003 0.997
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.003 0.997
E78.0 Pure hypercholesterolaemia
0.000 0.003 0.997
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.004 0.996
E70-E90 Metabolic disorders
0.000 0.004 0.996
E05.9 Thyrotoxicosis, unspecified
0.000 0.005 0.995
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.007 0.993
E14.9 Without complications
0.000 0.007 0.993
E14.3 With ophthalmic complications
0.000 0.008 0.992
E16 Other disorders of pancreatic internal secretion
0.000 0.012 0.988
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.013 0.987
E11.3 With ophthalmic complications
0.000 0.016 0.984
E16.2 Hypoglycaemia, unspecified
0.000 0.018 0.982
H36.0 Diabetic retinopathy
0.000 0.044 0.956
I22 Subsequent myocardial infarction
0.000 0.050 0.950
E10.2 With renal complications
0.000 0.052 0.948
M06.9 Rheumatoid arthritis, unspecified
0.000 0.053 0.947
I21 Acute myocardial infarction
0.000 0.057 0.943
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.060 0.940
I21.9 Acute myocardial infarction, unspecified
0.000 0.062 0.938
I24 Other acute ischaemic heart diseases
0.000 0.072 0.928
I25.5 Ischaemic cardiomyopathy
0.000 0.073 0.927
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.074 0.926
E11.1 With ketoacidosis
0.000 0.085 0.915
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.095 0.905
E10.0 With coma
0.000 0.105 0.895
E06 Thyroiditis
0.000 0.106 0.894
E88 Other metabolic disorders
0.000 0.115 0.885
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.118 0.882
I25.2 Old myocardial infarction
0.000 0.125 0.875
E13 Other specified diabetes mellitus
0.000 0.125 0.875
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.127 0.873
E10.5 With peripheral circulatory complications
0.000 0.127 0.873
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.127 0.873
I24.8 Other forms of acute ischaemic heart disease
0.000 0.128 0.872
E10.8 With unspecified complications
0.000 0.136 0.864
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.137 0.863
E11.0 With coma
0.000 0.147 0.853
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.148 0.852
E40-E46 Malnutrition
0.000 0.159 0.841
E14.6 With other specified complications
0.000 0.159 0.841
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.161 0.839
E06.3 Autoimmune thyroiditis
0.000 0.165 0.835
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.166 0.834
E14.8 With unspecified complications
0.000 0.179 0.821
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.183 0.817
E14.4 With neurological complications
0.000 0.186 0.814
E78.1 Pure hyperglyceridaemia
0.000 0.192 0.808
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.196 0.804
E10.6 With other specified complications
0.000 0.211 0.789
E11.2 With renal complications
0.000 0.213 0.787
E89.0 Postprocedural hypothyroidism
0.000 0.217 0.783
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.220 0.780
E74 Other disorders of carbohydrate metabolism
0.000 0.228 0.772
E13.9 Without complications
0.000 0.234 0.766
M06 Other rheumatoid arthritis
0.000 0.238 0.762
E78.6 Lipoprotein deficiency
0.000 0.238 0.762
E78.2 Mixed hyperlipidaemia
0.000 0.242 0.758
E78.4 Other hyperlipidaemia
0.000 0.244 0.756
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.245 0.755
E14.1 With ketoacidosis
0.000 0.246 0.754
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.248 0.752
E89.3 Postprocedural hypopituitarism
0.000 0.260 0.740
E14.2 Withrenal complications
0.000 0.264 0.736
E88.2 Lipomatosis, not elsewhere classified
0.000 0.268 0.732
E79 Disorders of purine and pyrimidine metabolism
0.000 0.269 0.731
E46 Unspecified protein-energy malnutrition
0.000 0.272 0.728
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.276 0.724
E14.5 With peripheral circulatory complications
0.000 0.280 0.719
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.281 0.719
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.716
E78.3 Hyperchylomicronaemia
0.000 0.286 0.714
E77 Disorders of glycoprotein metabolism
0.000 0.286 0.714
E76 Disorders of glycosaminoglycan metabolism
0.000 0.286 0.714
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.286 0.714
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.286 0.714
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.286 0.713
E15 Nondiabetic hypoglycaemic coma
0.000 0.288 0.712
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.291 0.709
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.291 0.709
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.291 0.709
E16.4 Abnormal secretion of gastrin
0.000 0.291 0.709
E16.3 Increased secretion of glucagon
0.000 0.291 0.709
E16.1 Other hypoglycaemia
0.000 0.292 0.708
I25.4 Coronary artery aneurysm
0.000 0.292 0.707
E84 Cystic fibrosis
0.000 0.293 0.707
E73 Lactose intolerance
0.000 0.301 0.699
E70 Disorders of aromatic amino-acid metabolism
0.000 0.306 0.694
I23 Certain current complications following acute myocardial infarction
0.000 0.306 0.694
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.307 0.693
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.309 0.691
M06.3 Rheumatoid nodule
0.000 0.311 0.689
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.313 0.687
E06.5 Other chronic thyroiditis
0.000 0.323 0.676
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.324 0.676
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.325 0.674
E88.3 Tumour lysis syndrome
0.000 0.327 0.673
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.328 0.672
M06.0 Seronegative rheumatoid arthritis
0.000 0.330 0.670
E13.3 With ophthalmic complications
0.000 0.331 0.669
I25.6 Silent myocardial ischaemia
0.000 0.335 0.665
E88.9 Metabolic disorder, unspecified
0.000 0.336 0.664
E11.6 With other specified complications
0.000 0.336 0.664
E89.4 Postprocedural ovarian failure
0.000 0.349 0.651
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.353 0.647
E72 Other disorders of amino-acid metabolism
0.000 0.356 0.644
E06.4 Drug-induced thyroiditis
0.000 0.359 0.641
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.359 0.641
E06.0 Acute thyroiditis
0.000 0.359 0.641
E88.8 Other specified metabolic disorders
0.000 0.369 0.631
E13.8 With unspecified complications
0.000 0.373 0.627
E13.7 With multiple complications
0.000 0.373 0.627
E13.6 With other specified complications
0.000 0.373 0.627
E13.5 With peripheral circulatory complications
0.000 0.373 0.627
E13.4 With neurological complications
0.000 0.373 0.627
E13.2 With renal complications
0.000 0.373 0.627
E13.1 With ketoacidosis
0.000 0.373 0.627
E13.0 With coma
0.000 0.373 0.627
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.374 0.626
E89.5 Postprocedural testicular hypofunction
0.000 0.374 0.626
E89.1 Postprocedural hypoinsulinaemia
0.000 0.374 0.626
E20-E35 Disorders of other endocrine glands
0.000 0.380 0.620
E78.8 Other disorders of lipoprotein metabolism
0.000 0.382 0.618
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.382 0.618
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.385 0.615
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.389 0.611
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.397 0.603
E45 Retarded development following protein-energy malnutrition
0.000 0.397 0.603
E43 Unspecified severe protein-energy malnutrition
0.000 0.397 0.603
E42 Marasmic kwashiorkor
0.000 0.397 0.603
E41 Nutritional marasmus
0.000 0.397 0.603
E40 Kwashiorkor
0.000 0.397 0.603
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.397 0.603
E14.0 With coma
0.000 0.400 0.599
E06.1 Subacute thyroiditis
0.000 0.404 0.596
I25.3 Aneurysm of heart
0.000 0.407 0.593
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.409 0.591
I20.1 Angina pectoris with documented spasm
0.000 0.416 0.584
I22.8 Subsequent myocardial infarction of other sites
0.000 0.422 0.578
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.422 0.578
E03.1 Congenital hypothyroidism without goitre
0.000 0.422 0.577
M06.34 Rheumatoid nodule (Hand)
0.000 0.429 0.571
E06.9 Thyroiditis, unspecified
0.000 0.430 0.570
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.430 0.569
E80.6 Other disorders of bilirubin metabolism
0.000 0.431 0.569
E83.1 Disorders of iron metabolism
0.563 0.437 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.440 0.560
I24.1 Dressler's syndrome
0.000 0.441 0.559
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.447 0.553
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.447 0.553
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.447 0.553
E74.2 Disorders of galactose metabolism
0.000 0.447 0.553
E74.1 Disorders of fructose metabolism
0.000 0.447 0.553
E74.0 Glycogen storage disease
0.000 0.447 0.553
E23 Hypofunction and other disorders of pituitary gland
0.000 0.451 0.549
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.451 0.549
M06.8 Other specified rheumatoid arthritis
0.000 0.453 0.547
M06.2 Rheumatoid bursitis
0.000 0.453 0.547
M06.1 Adult-onset Still's disease
0.000 0.453 0.547
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.459 0.541
E05.8 Other thyrotoxicosis
0.000 0.460 0.540
E11.8 With unspecified complications
0.000 0.465 0.535
E03.8 Other specified hypothyroidism
0.000 0.468 0.532
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.476 0.524
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.476 0.524
E79.1 Lesch-Nyhan syndrome
0.000 0.476 0.524
I23.8 Other current complications following acute myocardial infarction
0.000 0.478 0.522
E07 Other disorders of thyroid
0.000 0.479 0.521
E23.6 Other disorders of pituitary gland
0.000 0.479 0.521
E11.5 With peripheral circulatory complications
0.000 0.480 0.520
E86 Volume depletion
0.000 0.481 0.519
E24 Cushing's syndrome
0.000 0.483 0.517
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E71.3 Disorders of fatty-acid metabolism
0.000 0.488 0.512
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.488 0.512
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.488 0.512
E71.0 Maple-syrup-urine disease
0.000 0.488 0.512
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.488 0.512
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.488 0.512
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.488 0.512
E76.2 Other mucopolysaccharidoses
0.000 0.488 0.512
E76.1 Mucopolysaccharidosis, type II
0.000 0.488 0.512
E76.0 Mucopolysaccharidosis, type I
0.000 0.488 0.512
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.488 0.512
E77.8 Other disorders of glycoprotein metabolism
0.000 0.488 0.512
E77.1 Defects in glycoprotein degradation
0.000 0.488 0.512
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.488 0.512
H36 Retinal disorders in diseases classified elsewhere
0.000 0.490 0.510
E50-E64 Other nutritional deficiencies
0.000 0.490 0.510
E84.8 Cystic fibrosis with other manifestations
0.000 0.493 0.507
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.493 0.507
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.493 0.507
E73.8 Other lactose intolerance
0.000 0.499 0.501
E73.1 Secondary lactase deficiency
0.000 0.499 0.501
E73.0 Congenital lactase deficiency
0.000 0.499 0.501
G35 Multiple sclerosis
0.500 0.500 0.000
E84.9 Cystic fibrosis, unspecified
0.000 0.500 0.499
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.502 0.497
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.502 0.497
E70.2 Disorders of tyrosine metabolism
0.000 0.502 0.497
E70.1 Other hyperphenylalaninaemias
0.000 0.502 0.497
E70.0 Classical phenylketonuria
0.000 0.502 0.497
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.502 0.497
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.502 0.497
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.502 0.497
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.502 0.497
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.502 0.497
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.502 0.497
E75.6 Lipid storage disorder, unspecified
0.000 0.504 0.496
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.504 0.496
E75.3 Sphingolipidosis, unspecified
0.000 0.504 0.496
E75.2 Other sphingolipidosis
0.000 0.504 0.496
E75.1 Other gangliosidosis
0.000 0.504 0.496
E75.0 GM2 gangliosidosis
0.000 0.504 0.496
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.506 0.494
M06.38 Rheumatoid nodule (Other)
0.000 0.506 0.494
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.506 0.494
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.506 0.494
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.506 0.494
E80.2 Other porphyria
0.000 0.509 0.491
E80.1 Porphyria cutanea tarda
0.000 0.512 0.488
K90 Intestinal malabsorption
0.000 0.512 0.488
E73.9 Lactose intolerance, unspecified
0.000 0.514 0.486
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.516 0.484
E80.5 Crigler-Najjar syndrome
0.000 0.516 0.484
E80.3 Defects of catalase and peroxydase
0.000 0.516 0.484
E80.0 Hereditary erythropoietic porphyria
0.000 0.516 0.484
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.519 0.481
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.519 0.481
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.519 0.481
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.519 0.481
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.519 0.481
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.519 0.481
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.522 0.478
E70.3 Albinism
0.000 0.522 0.477
E28 Ovarian dysfunction
0.000 0.525 0.475
E75.5 Other lipid storage disorders
0.000 0.527 0.473
G35-G37 Demyelinating diseases of the central nervous system
0.468 0.532 0.000
E22 Hyperfunction of pituitary gland
0.000 0.533 0.467
G37 Other demyelinating diseases of central nervous system
0.464 0.536 0.000
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.538 0.461
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.538 0.461
E72.5 Disorders of glycine metabolism
0.000 0.538 0.461
E72.4 Disorders of ornithine metabolism
0.000 0.538 0.461
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.538 0.461
E72.2 Disorders of urea cycle metabolism
0.000 0.538 0.461
E65-E68 Obesity and other hyperalimentation
0.000 0.542 0.458
G37.9 Demyelinating disease of central nervous system, unspecified
0.456 0.544 0.000
I21.4 Acute subendocardial myocardial infarction
0.000 0.549 0.451
E61 Deficiency of other nutrient elements
0.000 0.549 0.451
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.550 0.449
E23.2 Diabetes insipidus
0.000 0.554 0.446
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.555 0.444
E32 Diseases of thymus
0.000 0.555 0.444
E31 Polyglandular dysfunction
0.000 0.555 0.444
E30 Disorders of puberty, not elsewhere classified
0.000 0.555 0.444
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.556 0.443
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.557 0.442
E21.3 Hyperparathyroidism, unspecified
0.000 0.565 0.435
M06.33 Rheumatoid nodule (Forearm)
0.000 0.566 0.434
E72.0 Disorders of amino-acid transport
0.000 0.566 0.434
E44.1 Mild protein-energy malnutrition
0.000 0.567 0.432
E44.0 Moderate protein-energy malnutrition
0.000 0.567 0.432
E24.0 Pituitary-dependent Cushing's disease
0.000 0.573 0.427
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.575 0.424
E24.2 Drug-induced Cushing's syndrome
0.000 0.578 0.422
M06.4 Inflammatory polyarthropathy
0.000 0.578 0.422
E26 Hyperaldosteronism
0.000 0.579 0.421
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.579 0.421
E61.1 Iron deficiency
0.000 0.582 0.418
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.594 0.405
E23.7 Disorder of pituitary gland, unspecified
0.000 0.601 0.399
E28.2 Polycystic ovarian syndrome
0.000 0.603 0.397
E25 Adrenogenital disorders
0.000 0.605 0.395
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.606 0.394
E23.1 Drug-induced hypopituitarism
0.000 0.606 0.394
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.608 0.392
M06.18 Adult-onset Still's disease (Other)
0.000 0.608 0.392
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.608 0.392
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.608 0.392
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.608 0.392
M06.14 Adult-onset Still's disease (Hand)
0.000 0.608 0.392
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.608 0.392
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.608 0.392
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.608 0.392
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.608 0.392
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.608 0.392
M06.28 Rheumatoid bursitis (Other)
0.000 0.608 0.392
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.608 0.392
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.608 0.392
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.608 0.392
M06.24 Rheumatoid bursitis (Hand)
0.000 0.608 0.392
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.608 0.392
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.608 0.392
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.608 0.392
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.608 0.392
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.608 0.392
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.608 0.392
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.608 0.392
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.608 0.392
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.608 0.392
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.608 0.392
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.608 0.392
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.608 0.392
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.608 0.392
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.608 0.392
K90.9 Intestinal malabsorption, unspecified
0.000 0.611 0.389
E20 Hypoparathyroidism
0.000 0.612 0.388
G37.8 Other specified demyelinating diseases of central nervous system
0.385 0.615 0.000
E22.0 Acromegaly and pituitary gigantism
0.000 0.615 0.385
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.616 0.384
E85 Amyloidosis
0.001 0.621 0.379
E07.1 Dyshormogenetic goitre
0.000 0.626 0.374
E07.0 Hypersecretion of calcitonin
0.000 0.626 0.374
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.629 0.371
E24.3 Ectopic ACTH syndrome
0.000 0.629 0.371
E24.1 Nelson's syndrome
0.000 0.629 0.371
E21.2 Other hyperparathyroidism
0.000 0.632 0.368
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.634 0.366
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.634 0.366
E63 Other nutritional deficiencies
0.000 0.634 0.366
E51 Thiamine deficiency
0.000 0.634 0.366
E50 Vitamin A deficiency
0.000 0.634 0.366
E60 Dietary zinc deficiency
0.000 0.634 0.366
E59 Dietary selenium deficiency
0.000 0.634 0.366
E52 Niacin deficiency [pellagra]
0.000 0.634 0.366
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.636 0.364
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.364 0.636 0.000
E24.8 Other Cushing's syndrome
0.000 0.636 0.364
E07.8 Other specified disorders of thyroid
0.000 0.637 0.362
E56 Other vitamin deficiencies
0.000 0.639 0.360
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.641 0.359
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.647 0.353
K90.3 Pancreatic steatorrhoea
0.000 0.650 0.350
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.650 0.350
K90.1 Tropical sprue
0.000 0.650 0.350
E21.4 Other specified disorders of parathyroid gland
0.000 0.652 0.348
K90.8 Other intestinal malabsorption
0.000 0.655 0.344
E24.9 Cushing's syndrome, unspecified
0.000 0.656 0.344
E28.9 Ovarian dysfunction, unspecified
0.000 0.660 0.340
E28.8 Other ovarian dysfunction
0.000 0.660 0.340
E28.1 Androgen excess
0.000 0.660 0.340
E28.0 Oestrogen excess
0.000 0.660 0.340
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.661 0.339
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.665 0.335
E22.8 Other hyperfunction of pituitary gland
0.000 0.665 0.335
E65 Localised adiposity
0.000 0.665 0.335
E58 Dietary calcium deficiency
0.000 0.666 0.334
E89.2 Postprocedural hypoparathyroidism
0.001 0.666 0.333
G37.5 Concentric sclerosis [Balo]
0.333 0.667 0.000
G37.4 Subacute necrotising myelitis
0.333 0.667 0.000
G37.2 Central pontine myelinolysis
0.333 0.667 0.000
G37.1 Central demyelination of corpus callosum
0.333 0.667 0.000
G37.0 Diffuse sclerosis
0.333 0.667 0.000
E67 Other hyperalimentation
0.000 0.672 0.328
E68 Sequelae of hyperalimentation
0.000 0.672 0.328
G36 Other acute disseminated demyelination
0.324 0.676 0.000
E61.9 Deficiency of nutrient element, unspecified
0.000 0.676 0.324
E61.8 Deficiency of other specified nutrient elements
0.000 0.676 0.324
E61.7 Deficiency of multiple nutrient elements
0.000 0.676 0.324
E61.6 Vanadium deficiency
0.000 0.676 0.324
E61.5 Molybdenum deficiency
0.000 0.676 0.324
E61.4 Chromium deficiency
0.000 0.676 0.324
E61.3 Manganese deficiency
0.000 0.676 0.324
E61.0 Copper deficiency
0.000 0.676 0.324
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.680 0.320
E30.9 Disorder of puberty, unspecified
0.000 0.681 0.319
E30.8 Other disorders of puberty
0.000 0.681 0.319
E30.1 Precocious puberty
0.000 0.681 0.319
E30.0 Delayed puberty
0.000 0.681 0.319
E31.9 Polyglandular dysfunction, unspecified
0.000 0.681 0.319
E31.8 Other polyglandular dysfunction
0.000 0.681 0.319
E31.1 Polyglandular hyperfunction
0.000 0.681 0.319
E31.0 Autoimmune polyglandular failure
0.000 0.681 0.319
E32.9 Disease of thymus, unspecified
0.000 0.681 0.319
E32.8 Other diseases of thymus
0.000 0.681 0.319
E32.1 Abscess of thymus
0.000 0.681 0.319
E32.0 Persistent hyperplasia of thymus
0.000 0.681 0.319
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.681 0.319
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.681 0.319
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.681 0.319
E29 Testicular dysfunction
0.000 0.686 0.314
E54 Ascorbic acid deficiency
0.000 0.688 0.312
E27 Other disorders of adrenal gland
0.000 0.689 0.311
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.697 0.302
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.697 0.302
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.697 0.302
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.697 0.302
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.697 0.302
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.697 0.302
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.697 0.302
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.697 0.302
E26.9 Hyperaldosteronism, unspecified
0.000 0.698 0.302
E26.8 Other hyperaldosteronism
0.000 0.698 0.302
E26.1 Secondary hyperaldosteronism
0.000 0.698 0.302
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.702 0.298
E83 Disorders of mineral metabolism
0.241 0.703 0.057
E28.3 Primary ovarian failure
0.000 0.705 0.295
E61.2 Magnesium deficiency
0.000 0.710 0.290
E25.9 Adrenogenital disorder, unspecified
0.000 0.717 0.283
E25.8 Other adrenogenital disorders
0.000 0.717 0.283
E26.0 Primary hyperaldosteronism
0.000 0.721 0.279
E20.1 Pseudohypoparathyroidism
0.000 0.722 0.278
E20.0 Idiopathic hypoparathyroidism
0.000 0.722 0.278
E34 Other endocrine disorders
0.001 0.722 0.277
E27.9 Disorder of adrenal gland, unspecified
0.000 0.726 0.274
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.728 0.271
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.728 0.271
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.728 0.271
E50.9 Vitamin A deficiency, unspecified
0.000 0.737 0.262
E50.8 Other manifestations of vitamin A deficiency
0.000 0.737 0.262
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.737 0.262
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.737 0.262
E50.5 Vitamin A deficiency with night blindness
0.000 0.737 0.262
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.737 0.262
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.737 0.262
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.737 0.262
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.737 0.262
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.737 0.262
E51.9 Thiamine deficiency, unspecified
0.000 0.737 0.262
E51.8 Other manifestations of thiamine deficiency
0.000 0.737 0.262
E51.2 Wernicke's encephalopathy
0.000 0.737 0.262
E51.1 Beriberi
0.000 0.737 0.262
E63.9 Nutritional deficiency, unspecified
0.000 0.737 0.262
E63.8 Other specified nutritional deficiencies
0.000 0.737 0.262
E63.1 Imbalance of constituents of food intake
0.000 0.737 0.262
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.737 0.262
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.737 0.262
E64.8 Sequelae of other nutritional deficiencies
0.000 0.737 0.262
E64.3 Sequelae of rickets
0.000 0.737 0.262
E64.2 Sequelae of vitamin C deficiency
0.000 0.737 0.262
E64.1 Sequelae of vitamin A deficiency
0.000 0.737 0.262
E64.0 Sequelae of protein-energy malnutrition
0.000 0.737 0.262
E56.9 Vitamin deficiency, unspecified
0.000 0.741 0.258
E56.8 Deficiency of other vitamins
0.000 0.741 0.258
E56.0 Deficiency of vitamin E
0.000 0.741 0.258
E20.9 Hypoparathyroidism, unspecified
0.000 0.742 0.258
E56.1 Deficiency of vitamin K
0.000 0.747 0.253
E55 Vitamin D deficiency
0.000 0.747 0.253
E20.8 Other hypoparathyroidism
0.000 0.752 0.247
E85.4 Organ-limited amyloidosis
0.000 0.755 0.244
E22.1 Hyperprolactinaemia
0.000 0.757 0.243
E67.8 Other specified hyperalimentation
0.000 0.764 0.235
E67.3 Hypervitaminosis D
0.000 0.764 0.235
E67.2 Megavitamin-B6 syndrome
0.000 0.764 0.235
E67.1 Hypercarotenaemia
0.000 0.764 0.235
E67.0 Hypervitaminosis A
0.000 0.764 0.235
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.767 0.233
G36.9 Acute disseminated demyelination, unspecified
0.232 0.767 0.000
G36.8 Other specified acute disseminated demyelination
0.232 0.767 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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