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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2857605
log Bayes Factor = 73.6921
Chromosome 6   position 31,524,851  (GRCh37) Explore rs2857605 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
L40.9 Psoriasis, unspecified
0.000 0.001 0.999
I25.1 Atherosclerotic heart disease
0.000 0.001 0.999
I20 Angina pectoris
0.000 0.002 0.998
I20.9 Angina pectoris, unspecified
0.000 0.002 0.998
L40-L45 Papulosquamous disorders
0.000 0.003 0.997
L43 Lichen planus
0.000 0.004 0.996
L43.9 Lichen planus, unspecified
0.000 0.005 0.995
L40.5 Arthropathic psoriasis
0.000 0.006 0.994
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.008 0.992
E83.1 Disorders of iron metabolism
0.992 0.008 0.000
E14.3 With ophthalmic complications
0.000 0.012 0.988
E14.9 Without complications
0.000 0.016 0.984
E10.4 With neurological complications
0.000 0.018 0.982
G35-G37 Demyelinating diseases of the central nervous system
0.982 0.018 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.019 0.981
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.019 0.981
G37 Other demyelinating diseases of central nervous system
0.979 0.021 0.000
E10.1 With ketoacidosis
0.000 0.026 0.974
G37.9 Demyelinating disease of central nervous system, unspecified
0.967 0.033 0.000
I24 Other acute ischaemic heart diseases
0.000 0.034 0.966
E70-E90 Metabolic disorders
0.004 0.039 0.958
I22 Subsequent myocardial infarction
0.000 0.040 0.960
I25.5 Ischaemic cardiomyopathy
0.000 0.043 0.957
E00-E07 Disorders of thyroid gland
0.000 0.053 0.947
E03.9 Hypothyroidism, unspecified
0.000 0.054 0.946
E03 Other hypothyroidism
0.000 0.055 0.945
E11.3 With ophthalmic complications
0.000 0.071 0.929
E78.8 Other disorders of lipoprotein metabolism
0.000 0.085 0.915
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.096 0.904
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.098 0.902
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.101 0.899
E10.2 With renal complications
0.000 0.104 0.896
I24.8 Other forms of acute ischaemic heart disease
0.000 0.114 0.886
E13 Other specified diabetes mellitus
0.000 0.115 0.885
J45.9 Asthma, unspecified
0.000 0.117 0.883
I25.3 Aneurysm of heart
0.000 0.118 0.882
I20.0 Unstable angina
0.000 0.126 0.874
I25.2 Old myocardial infarction
0.000 0.131 0.869
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.134 0.866
G37.8 Other specified demyelinating diseases of central nervous system
0.863 0.137 0.000
E10.8 With unspecified complications
0.000 0.139 0.861
L43.8 Other lichen planus
0.000 0.142 0.858
E10.5 With peripheral circulatory complications
0.000 0.148 0.852
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.149 0.851
I10 Essential (primary) hypertension
0.000 0.149 0.851
E16 Other disorders of pancreatic internal secretion
0.000 0.154 0.846
E11.1 With ketoacidosis
0.000 0.155 0.845
E10.0 With coma
0.000 0.164 0.836
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.835 0.165 0.000
E11.6 With other specified complications
0.000 0.178 0.822
E11.0 With coma
0.000 0.182 0.818
E83 Disorders of mineral metabolism
0.777 0.191 0.032
E10.6 With other specified complications
0.000 0.193 0.807
E13.9 Without complications
0.000 0.197 0.803
L42 Pityriasis rosea
0.000 0.200 0.800
I10-I15 Hypertensive diseases
0.000 0.209 0.791
E14.8 With unspecified complications
0.000 0.212 0.788
E78.2 Mixed hyperlipidaemia
0.000 0.237 0.763
E16.2 Hypoglycaemia, unspecified
0.000 0.238 0.762
E14.1 With ketoacidosis
0.000 0.244 0.756
E74 Other disorders of carbohydrate metabolism
0.002 0.245 0.753
I23 Certain current complications following acute myocardial infarction
0.000 0.247 0.753
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.249 0.751
L40.1 Generalised pustular psoriasis
0.000 0.249 0.751
L40.8 Other psoriasis
0.000 0.261 0.739
E14.6 With other specified complications
0.000 0.265 0.734
E78.6 Lipoprotein deficiency
0.000 0.267 0.733
E40-E46 Malnutrition
0.000 0.268 0.731
E83.3 Disorders of phosphorus metabolism
0.722 0.271 0.007
E16.1 Other hypoglycaemia
0.000 0.279 0.721
E07 Other disorders of thyroid
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.716
E14.2 Withrenal complications
0.000 0.283 0.716
E14.0 With coma
0.000 0.283 0.716
L44 Other papulosquamous disorders
0.000 0.285 0.715
L41 Parapsoriasis
0.000 0.285 0.715
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.285 0.715
L43.3 Subacute (active) lichen planus
0.000 0.286 0.714
L43.2 Lichenoid drug reaction
0.000 0.286 0.714
L43.1 Bullous lichen planus
0.000 0.286 0.714
L43.0 Hypertrophic lichen planus
0.000 0.286 0.714
E14.4 With neurological complications
0.000 0.289 0.711
E78.3 Hyperchylomicronaemia
0.000 0.296 0.704
L40.3 Pustulosis palmaris et plantaris
0.000 0.297 0.703
G37.5 Concentric sclerosis [Balo]
0.702 0.298 0.000
G37.4 Subacute necrotising myelitis
0.702 0.298 0.000
G37.2 Central pontine myelinolysis
0.702 0.298 0.000
G37.1 Central demyelination of corpus callosum
0.702 0.298 0.000
G37.0 Diffuse sclerosis
0.702 0.298 0.000
G36 Other acute disseminated demyelination
0.699 0.301 0.000
E79 Disorders of purine and pyrimidine metabolism
0.003 0.301 0.696
I12 Hypertensive renal disease
0.000 0.309 0.691
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.310 0.690
E14.5 With peripheral circulatory complications
0.000 0.310 0.690
E77 Disorders of glycoprotein metabolism
0.003 0.311 0.687
E76 Disorders of glycosaminoglycan metabolism
0.003 0.311 0.687
E72 Other disorders of amino-acid metabolism
0.003 0.311 0.687
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.003 0.311 0.687
E70 Disorders of aromatic amino-acid metabolism
0.003 0.311 0.687
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.003 0.311 0.687
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.003 0.313 0.684
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.321 0.679
E00 Congenital iodine-deficiency syndrome
0.000 0.321 0.679
E03.5 Myxoedema coma
0.000 0.322 0.678
E03.4 Atrophy of thyroid (acquired)
0.000 0.322 0.678
E03.3 Postinfectious hypothyroidism
0.000 0.322 0.678
E03.1 Congenital hypothyroidism without goitre
0.000 0.322 0.678
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.322 0.678
E78.4 Other hyperlipidaemia
0.000 0.337 0.663
I15 Secondary hypertension
0.000 0.340 0.660
I24.1 Dressler's syndrome
0.000 0.342 0.658
H36.0 Diabetic retinopathy
0.000 0.345 0.655
E15 Nondiabetic hypoglycaemic coma
0.000 0.353 0.647
I12.9 Hypertensive renal disease without renal failure
0.000 0.357 0.643
E50-E64 Other nutritional deficiencies
0.000 0.358 0.642
E78.1 Pure hyperglyceridaemia
0.000 0.359 0.640
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.360 0.640
E84 Cystic fibrosis
0.003 0.361 0.636
E11.2 With renal complications
0.000 0.362 0.638
E13.8 With unspecified complications
0.000 0.365 0.635
E13.7 With multiple complications
0.000 0.365 0.635
E13.6 With other specified complications
0.000 0.365 0.635
E13.5 With peripheral circulatory complications
0.000 0.365 0.635
E13.4 With neurological complications
0.000 0.365 0.635
E13.3 With ophthalmic complications
0.000 0.365 0.635
E13.2 With renal complications
0.000 0.365 0.635
E13.1 With ketoacidosis
0.000 0.365 0.635
E13.0 With coma
0.000 0.365 0.635
I11 Hypertensive heart disease
0.000 0.367 0.633
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.375 0.625
I25.4 Coronary artery aneurysm
0.000 0.378 0.621
E78.5 Hyperlipidaemia, unspecified
0.000 0.381 0.619
E88 Other metabolic disorders
0.002 0.392 0.606
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.392 0.606
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.393 0.607
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.393 0.607
E16.4 Abnormal secretion of gastrin
0.000 0.393 0.607
E16.3 Increased secretion of glucagon
0.000 0.393 0.607
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.399 0.600
L40.0 Psoriasis vulgaris
0.000 0.410 0.590
E83.9 Disorder of mineral metabolism, unspecified
0.557 0.420 0.023
E83.8 Other disorders of mineral metabolism
0.557 0.420 0.023
E83.2 Disorders of zinc metabolism
0.557 0.420 0.023
E83.0 Disorders of copper metabolism
0.557 0.420 0.023
H36 Retinal disorders in diseases classified elsewhere
0.000 0.423 0.577
E61 Deficiency of other nutrient elements
0.000 0.423 0.577
I23.8 Other current complications following acute myocardial infarction
0.000 0.424 0.575
I13 Hypertensive heart and renal disease
0.000 0.433 0.567
E07.9 Disorder of thyroid, unspecified
0.000 0.433 0.567
Chapter IX Diseases of the circulatory system
0.000 0.438 0.562
E03.8 Other specified hypothyroidism
0.000 0.439 0.561
E83.5 Disorders of calcium metabolism
0.557 0.441 0.002
I22.8 Subsequent myocardial infarction of other sites
0.000 0.445 0.555
E46 Unspecified protein-energy malnutrition
0.000 0.447 0.553
I15.1 Hypertension secondary to other renal disorders
0.000 0.447 0.553
E06 Thyroiditis
0.000 0.451 0.549
E11.5 With peripheral circulatory complications
0.000 0.453 0.547
E73 Lactose intolerance
0.003 0.454 0.543
E74.9 Disorder of carbohydrate metabolism, unspecified
0.002 0.458 0.540
E74.8 Other specified disorders of carbohydrate metabolism
0.002 0.458 0.540
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.002 0.458 0.540
E74.2 Disorders of galactose metabolism
0.002 0.458 0.540
E74.1 Disorders of fructose metabolism
0.002 0.458 0.540
E74.0 Glycogen storage disease
0.002 0.458 0.540
E11.8 With unspecified complications
0.000 0.459 0.541
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.460 0.540
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.460 0.540
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.460 0.540
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.460 0.540
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.460 0.540
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.460 0.540
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.460 0.540
E61.1 Iron deficiency
0.000 0.468 0.532
E85 Amyloidosis
0.003 0.469 0.528
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.469 0.530
I21 Acute myocardial infarction
0.000 0.475 0.525
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.475 0.524
E45 Retarded development following protein-energy malnutrition
0.000 0.475 0.524
E43 Unspecified severe protein-energy malnutrition
0.000 0.475 0.524
E42 Marasmic kwashiorkor
0.000 0.475 0.524
E41 Nutritional marasmus
0.000 0.475 0.524
E40 Kwashiorkor
0.000 0.475 0.524
H30-H36 Disorders of choroid and retina
0.000 0.479 0.521
E88.2 Lipomatosis, not elsewhere classified
0.001 0.479 0.520
H35 Other retinal disorders
0.000 0.484 0.516
E07.1 Dyshormogenetic goitre
0.000 0.485 0.515
E07.0 Hypersecretion of calcitonin
0.000 0.485 0.515
H35.8 Other specified retinal disorders
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
L41.9 Parapsoriasis, unspecified
0.000 0.487 0.512
L41.8 Other parapsoriasis
0.000 0.487 0.512
L41.5 Retiform parapsoriasis
0.000 0.487 0.512
L41.4 Large plaque parapsoriasis
0.000 0.487 0.512
L41.3 Small plaque parapsoriasis
0.000 0.487 0.512
L41.2 Lymphomatoid papulosis
0.000 0.487 0.512
L41.1 Pityriasis lichenoides chronica
0.000 0.487 0.512
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.487 0.512
L44.9 Papulosquamous disorder, unspecified
0.000 0.487 0.512
L44.8 Other specified papulosquamous disorders
0.000 0.487 0.512
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.487 0.512
L44.3 Lichen ruber moniliformis
0.000 0.487 0.512
L44.2 Lichen striatus
0.000 0.487 0.512
L44.1 Lichen nitidus
0.000 0.487 0.512
L44.0 Pityriasis rubra pilaris
0.000 0.487 0.512
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.002 0.489 0.509
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.001 0.493 0.505
K90 Intestinal malabsorption
0.000 0.494 0.506
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.495 0.505
I20.1 Angina pectoris with documented spasm
0.000 0.496 0.504
G36.9 Acute disseminated demyelination, unspecified
0.501 0.499 0.000
G36.8 Other specified acute disseminated demyelination
0.501 0.499 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.501 0.499 0.000
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.002 0.499 0.499
E79.8 Other disorders of purine and pyrimidine metabolism
0.002 0.499 0.499
E79.1 Lesch-Nyhan syndrome
0.002 0.499 0.499
E07.8 Other specified disorders of thyroid
0.000 0.501 0.498
G36.0 Neuromyelitis optica [Devic]
0.496 0.504 0.000
I15.9 Seconday hypertension, unspecified
0.000 0.504 0.496
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.002 0.506 0.492
E70.8 Other disorders of aromatic amino-acid metabolism
0.002 0.506 0.492
E70.3 Albinism
0.002 0.506 0.492
E70.2 Disorders of tyrosine metabolism
0.002 0.506 0.492
E70.1 Other hyperphenylalaninaemias
0.002 0.506 0.492
E70.0 Classical phenylketonuria
0.002 0.506 0.492
E71.3 Disorders of fatty-acid metabolism
0.002 0.506 0.492
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.002 0.506 0.492
E71.1 Other disorders of branched-chain amino-acid metabolism
0.002 0.506 0.492
E71.0 Maple-syrup-urine disease
0.002 0.506 0.492
E72.9 Disorder of amino-acid metabolism, unspecified
0.002 0.506 0.492
E72.8 Other specified disorders of amino-acid metabolism
0.002 0.506 0.492
E72.5 Disorders of glycine metabolism
0.002 0.506 0.492
E72.4 Disorders of ornithine metabolism
0.002 0.506 0.492
E72.3 Disorders of lysine and hydroxylysine metabolism
0.002 0.506 0.492
E72.2 Disorders of urea cycle metabolism
0.002 0.506 0.492
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.002 0.506 0.492
E72.0 Disorders of amino-acid transport
0.002 0.506 0.492
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.002 0.506 0.492
E76.8 Other disorders of glucosaminoglycan metabolism
0.002 0.506 0.492
E76.3 Mucopolysaccharidosis, unspecified
0.002 0.506 0.492
E76.2 Other mucopolysaccharidoses
0.002 0.506 0.492
E76.1 Mucopolysaccharidosis, type II
0.002 0.506 0.492
E76.0 Mucopolysaccharidosis, type I
0.002 0.506 0.492
E77.9 Disorder of glycoprotein metabolism, unspecified
0.002 0.506 0.492
E77.8 Other disorders of glycoprotein metabolism
0.002 0.506 0.492
E77.1 Defects in glycoprotein degradation
0.002 0.506 0.492
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.002 0.506 0.492
E75.6 Lipid storage disorder, unspecified
0.002 0.507 0.491
E75.4 Neuronal ceroid lipofuscinosis
0.002 0.507 0.491
E75.3 Sphingolipidosis, unspecified
0.002 0.507 0.491
E75.2 Other sphingolipidosis
0.002 0.507 0.491
E75.1 Other gangliosidosis
0.002 0.507 0.491
E75.0 GM2 gangliosidosis
0.002 0.507 0.491
E75.5 Other lipid storage disorders
0.002 0.510 0.488
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.513 0.487
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.513 0.487
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.513 0.487
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.513 0.487
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.513 0.487
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.513 0.487
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.513 0.487
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.513 0.487
I21.4 Acute subendocardial myocardial infarction
0.000 0.515 0.485
I15.8 Other secondary hypertension
0.000 0.527 0.473
I15.2 Hypertension secondary to endocrine disorders
0.000 0.527 0.473
I15.0 Renovascular hypertension
0.000 0.527 0.473
E80 Disorders of porphyrin and bilirubin metabolism
0.004 0.539 0.457
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.540 0.460
E63 Other nutritional deficiencies
0.000 0.540 0.460
E51 Thiamine deficiency
0.000 0.540 0.460
E50 Vitamin A deficiency
0.000 0.540 0.460
E60 Dietary zinc deficiency
0.000 0.540 0.460
E59 Dietary selenium deficiency
0.000 0.540 0.460
E58 Dietary calcium deficiency
0.000 0.540 0.460
E54 Ascorbic acid deficiency
0.000 0.540 0.460
E52 Niacin deficiency [pellagra]
0.000 0.540 0.460
E84.8 Cystic fibrosis with other manifestations
0.002 0.542 0.456
E84.1 Cystic fibrosis with intestinal manifestations
0.002 0.542 0.456
E84.0 Cystic fibrosis with pulmonary manifestations
0.002 0.542 0.456
E88.8 Other specified metabolic disorders
0.002 0.554 0.444
E56 Other vitamin deficiencies
0.000 0.564 0.436
E88.3 Tumour lysis syndrome
0.002 0.564 0.435
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.565 0.435
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.571 0.429
E88.9 Metabolic disorder, unspecified
0.002 0.573 0.426
H35.0 Background retinopathy and retinal vascular changes
0.000 0.579 0.421
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.581 0.419
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.586 0.414
E61.9 Deficiency of nutrient element, unspecified
0.000 0.586 0.413
E61.8 Deficiency of other specified nutrient elements
0.000 0.586 0.413
E61.7 Deficiency of multiple nutrient elements
0.000 0.586 0.413
E61.6 Vanadium deficiency
0.000 0.586 0.413
E61.5 Molybdenum deficiency
0.000 0.586 0.413
E61.4 Chromium deficiency
0.000 0.586 0.413
E61.3 Manganese deficiency
0.000 0.586 0.413
E61.0 Copper deficiency
0.000 0.586 0.413
H35.4 Peripheral retinal degeneration
0.000 0.590 0.410
E84.9 Cystic fibrosis, unspecified
0.002 0.592 0.405
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.593 0.407
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.593 0.407
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.593 0.407
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.593 0.407
H35.6 Retinal haemorrhage
0.000 0.594 0.406
E61.2 Magnesium deficiency
0.000 0.595 0.405
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.597 0.403
I00-I02 Acute rheumatic fever
0.000 0.597 0.403
E89.3 Postprocedural hypopituitarism
0.001 0.604 0.396
I12.0 Hypertensive renal disease with renal failure
0.000 0.604 0.396
H31 Other disorders of choroid
0.000 0.605 0.394
E06.5 Other chronic thyroiditis
0.000 0.606 0.394
E06.4 Drug-induced thyroiditis
0.000 0.606 0.394
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.606 0.394
E06.1 Subacute thyroiditis
0.000 0.606 0.394
E06.0 Acute thyroiditis
0.000 0.606 0.394
H35.5 Hereditary retinal dystrophy
0.000 0.607 0.393
E73.8 Other lactose intolerance
0.002 0.608 0.389
E73.1 Secondary lactase deficiency
0.002 0.608 0.389
E73.0 Congenital lactase deficiency
0.002 0.608 0.389
H35.2 Other proliferative retinopathy
0.000 0.611 0.389
H34 Retinal vascular occlusions
0.000 0.615 0.385
E65-E68 Obesity and other hyperalimentation
0.000 0.618 0.382
E85.8 Other amyloidosis
0.002 0.619 0.379
E85.2 Heredofamilial amyloidosis, unspecified
0.002 0.619 0.379
E85.1 Neuropathic heredofamilial amyloidosis
0.002 0.619 0.379
E85.0 Nonneuropathic heredofamilial amyloidosis
0.002 0.619 0.379
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.623 0.377
E44.1 Mild protein-energy malnutrition
0.000 0.624 0.376
E44.0 Moderate protein-energy malnutrition
0.000 0.624 0.376
H30 Chorioretinal inflammation
0.000 0.624 0.376
E85.9 Amyloidosis, unspecified
0.002 0.626 0.372
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.626 0.374
E11.4 With neurological complications
0.000 0.627 0.373
K90.8 Other intestinal malabsorption
0.000 0.628 0.372
I21.9 Acute myocardial infarction, unspecified
0.000 0.628 0.372
H35.1 Retinopathy of prematurity
0.000 0.630 0.370
H35.7 Separation of retinal layers
0.000 0.631 0.369
E89.2 Postprocedural hypoparathyroidism
0.001 0.634 0.366
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.001 0.637 0.362
E89.8 Other postprocedural endocrine and metabolic disorders
0.001 0.637 0.362
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.001 0.637 0.362
E89.5 Postprocedural testicular hypofunction
0.001 0.637 0.362
E89.1 Postprocedural hypoinsulinaemia
0.001 0.637 0.362
K90.3 Pancreatic steatorrhoea
0.000 0.637 0.363
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.637 0.363
K90.1 Tropical sprue
0.000 0.637 0.363
E05.5 Thyroid crisis or storm
0.000 0.638 0.362
E05.4 Thyrotoxicosis factitia
0.000 0.638 0.362
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.638 0.362
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.638 0.362
E88.1 Lipodystrophy, not elsewhere classified
0.002 0.640 0.358
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.645 0.355
E85.3 Secondary systemic amyloidosis
0.002 0.650 0.348
E06.9 Thyroiditis, unspecified
0.000 0.654 0.346
E80.6 Other disorders of bilirubin metabolism
0.003 0.660 0.337
E55 Vitamin D deficiency
0.000 0.667 0.333
E89.4 Postprocedural ovarian failure
0.001 0.667 0.332
H34.8 Other retinal vascular occlusions
0.000 0.669 0.331
E06.3 Autoimmune thyroiditis
0.000 0.669 0.331
E80.7 Disorder of bilirubin metabolism, unspecified
0.003 0.670 0.328
E80.5 Crigler-Najjar syndrome
0.003 0.670 0.328
E80.3 Defects of catalase and peroxydase
0.003 0.670 0.328
E80.2 Other porphyria
0.003 0.670 0.328
E80.1 Porphyria cutanea tarda
0.003 0.670 0.328
E80.0 Hereditary erythropoietic porphyria
0.003 0.670 0.328
E50.9 Vitamin A deficiency, unspecified
0.000 0.670 0.330
E50.8 Other manifestations of vitamin A deficiency
0.000 0.670 0.330
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.670 0.330
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.670 0.330
E50.5 Vitamin A deficiency with night blindness
0.000 0.670 0.330
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.670 0.330
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.670 0.330
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.670 0.330
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.670 0.330
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.670 0.330
E51.9 Thiamine deficiency, unspecified
0.000 0.670 0.330
E51.8 Other manifestations of thiamine deficiency
0.000 0.670 0.330
E51.2 Wernicke's encephalopathy
0.000 0.670 0.330
E51.1 Beriberi
0.000 0.670 0.330
E63.9 Nutritional deficiency, unspecified
0.000 0.670 0.330
E63.8 Other specified nutritional deficiencies
0.000 0.670 0.330
E63.1 Imbalance of constituents of food intake
0.000 0.670 0.330
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.670 0.330
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.670 0.330
E64.8 Sequelae of other nutritional deficiencies
0.000 0.670 0.330
E64.3 Sequelae of rickets
0.000 0.670 0.330
E64.2 Sequelae of vitamin C deficiency
0.000 0.670 0.330
E64.1 Sequelae of vitamin A deficiency
0.000 0.670 0.330
E64.0 Sequelae of protein-energy malnutrition
0.000 0.670 0.330
K90.9 Intestinal malabsorption, unspecified
0.000 0.672 0.328
E56.9 Vitamin deficiency, unspecified
0.000 0.687 0.313
E56.8 Deficiency of other vitamins
0.000 0.687 0.313
E56.0 Deficiency of vitamin E
0.000 0.687 0.313
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.688 0.312
H31.0 Chorioretinal scars
0.000 0.690 0.310
E05.8 Other thyrotoxicosis
0.000 0.691 0.308
E83.4 Disorders of magnesium metabolism
0.289 0.692 0.019
J45 Asthma
0.000 0.695 0.305
H31.1 Choroidal degeneration
0.000 0.700 0.300
H35.9 Retinal disorder, unspecified
0.000 0.701 0.299
K60.2 Anal fissure, unspecified
0.000 0.709 0.291
E53 Deficiency of other B group vitamins
0.000 0.709 0.291
E56.1 Deficiency of vitamin K
0.000 0.711 0.289
I02 Rheumatic chorea
0.000 0.711 0.289
I01 Rheumatic fever with heart involvement
0.000 0.711 0.289
I00 Rheumatic fever without mention of heart involvement
0.000 0.711 0.289
H31.3 Choroidal haemorrhage and rupture
0.000 0.714 0.286
E85.4 Organ-limited amyloidosis
0.003 0.714 0.283
H31.9 Disorder of choroid, unspecified
0.000 0.717 0.283
H31.4 Choroidal detachment
0.000 0.717 0.283
H31.2 Hereditary choroidal dystrophy
0.000 0.717 0.283
H34.0 Transient retinal artery occlusion
0.000 0.724 0.276
E67 Other hyperalimentation
0.000 0.726 0.274
E68 Sequelae of hyperalimentation
0.000 0.726 0.274
H30.9 Chorioretinal inflammation, unspecified
0.000 0.729 0.271
H30.8 Other chorioretinal inflammations
0.000 0.730 0.269
H30.2 Posterior cyclitis
0.000 0.730 0.269
H30.1 Disseminated chorioretinal inflammation
0.000 0.730 0.269
H30.0 Focal chorioretinal inflammation
0.000 0.730 0.269
H32.8 Other chorioretinal disorders in diseases classified elsewhere
0.000 0.732 0.268
H32.0 Chorioretinal inflammation in infectious and parasitic diseases classified elsewhere
0.000 0.732 0.268
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.002 0.740 0.259
H34.2 Other retinal artery occlusions
0.000 0.742 0.258
H34.9 Retinal vascular occlusion, unspecified
0.000 0.746 0.254
H31.8 Other specified disorders of choroid
0.000 0.751 0.249
E73.9 Lactose intolerance, unspecified
0.003 0.751 0.246
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.753 0.247
H34.1 Central retinal artery occlusion
0.000 0.759 0.241
E55.0 Rickets, active
0.000 0.761 0.239
I20.8 Other forms of angina pectoris
0.000 0.764 0.236
E05.9 Thyrotoxicosis, unspecified
0.000 0.776 0.224
E65 Localised adiposity
0.000 0.779 0.221
K60 Fissure and fistula of anal and rectal regions
0.000 0.780 0.220
J45.1 Nonallergic asthma
0.000 0.781 0.219
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.783 0.217
K90-K93 Other diseases of the digestive system
0.000 0.784 0.216
E53.1 Pyridoxine deficiency
0.000 0.791 0.208
E53.0 Riboflavin deficiency
0.000 0.791 0.208
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.793 0.207
I01.8 Other acute rheumatic heart disease
0.000 0.793 0.207
I01.2 Acute rheumatic myocarditis
0.000 0.793 0.207
I01.1 Acute rheumatic endocarditis
0.000 0.793 0.207
I01.0 Acute rheumatic pericarditis
0.000 0.793 0.207
I02.9 Rheumatic chorea without heart involvement
0.000 0.793 0.207
I02.0 Rheumatic chorea with heart involvement
0.000 0.793 0.207
K60.0 Acute anal fissure
0.000 0.799 0.201
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.001 0.800 0.200
Chapter XII Diseases of the skin and subcutaneous tissue
0.002 0.800 0.197
# Top node
0.000 0.803 0.197
E67.8 Other specified hyperalimentation
0.000 0.803 0.196
E67.3 Hypervitaminosis D
0.000 0.803 0.196
E67.2 Megavitamin-B6 syndrome
0.000 0.803 0.196
E67.1 Hypercarotenaemia
0.000 0.803 0.196
E67.0 Hypervitaminosis A
0.000 0.803 0.196
Chapter VII Diseases of the eye and adnexa
0.000 0.804 0.196
E20-E35 Disorders of other endocrine glands
0.002 0.806 0.192
J45.8 Mixed asthma
0.000 0.809 0.191
Chapter XI Diseases of the digestive system
0.000 0.813 0.187
H43-H45 Disorders of vitreous body and globe
0.000 0.814 0.186
J40-J47 Chronic lower respiratory diseases
0.000 0.815 0.185
E53.9 Vitamin B deficiency, unspecified
0.000 0.816 0.184
K60.5 Anorectal fistula
0.000 0.817 0.182
H43 Disorders of vitreous body
0.000 0.818 0.182
K70-K77 Diseases of liver
0.000 0.826 0.174
K55-K64 Other diseases of intestines
0.000 0.828 0.172
Chapter X Diseases of the respiratory system
0.000 0.832 0.168
H43.3 Other vitreous opacities
0.000 0.834 0.166
K75 Other inflammatory liver diseases
0.000 0.837 0.163
K74 Fibrosis and cirrhosis of liver
0.000 0.838 0.162
K60.4 Rectal fistula
0.000 0.840 0.160
J92.9 Pleural plaque without asbestos
0.000 0.840 0.160
K58 Irritable bowel syndrome
0.000 0.841 0.159
J42 Unspecified chronic bronchitis
0.000 0.842 0.158
J92 Pleural plaque
0.000 0.842 0.158

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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