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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2858312
log Bayes Factor = 111.228
Chromosome 6   position 32,667,230  (GRCh37) Explore rs2858312 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
J45.9 Asthma, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
N48 Other disorders of penis
1.000 0.000 0.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
N47 Redundant prepuce, phimosis and paraphimosis
1.000 0.000 0.000
E16.2 Hypoglycaemia, unspecified
0.000 0.001 0.999
N48.6 Balanitis xerotica obliterans
0.999 0.001 0.000
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
E10.4 With neurological complications
0.000 0.002 0.998
E16 Other disorders of pancreatic internal secretion
0.000 0.002 0.998
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.002 0.998
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.002 0.998
N40-N51 Diseases of male genital organs
0.996 0.004 0.000
E14.3 With ophthalmic complications
0.000 0.004 0.996
E10.2 With renal complications
0.000 0.006 0.994
E10.5 With peripheral circulatory complications
0.000 0.014 0.986
N48.1 Balanoposthitis
0.983 0.017 0.000
N48.0 Leukoplakia of penis
0.982 0.018 0.000
L90.0 Lichen sclerosus et atrophicus
0.943 0.057 0.000
R31 Unspecified haematuria
0.942 0.058 0.000
E50-E64 Other nutritional deficiencies
0.000 0.083 0.917
E55 Vitamin D deficiency
0.000 0.112 0.888
E00-E07 Disorders of thyroid gland
0.003 0.112 0.885
N45 Orchitis and epididymitis
0.884 0.116 0.000
L90 Atrophic disorders of skin
0.869 0.131 0.000
E55.9 Vitamin D deficiency, unspecified
0.000 0.132 0.868
N48.8 Other specified disorders of penis
0.859 0.141 0.000
L90.5 Scar conditions and fibrosis of skin
0.854 0.146 0.000
N48.5 Ulcer of penis
0.853 0.147 0.000
N44 Torsion of testis
0.850 0.150 0.000
E10.0 With coma
0.000 0.150 0.850
E14.9 Without complications
0.000 0.155 0.845
N48.2 Other inflammatory disorders of penis
0.842 0.158 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.001 0.161 0.839
E10.8 With unspecified complications
0.000 0.168 0.832
N48.9 Disorder of penis, unspecified
0.825 0.175 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.183 0.817
E14.6 With other specified complications
0.000 0.206 0.794
E14.8 With unspecified complications
0.000 0.208 0.792
E40-E46 Malnutrition
0.000 0.213 0.787
N45.9 Orchitis, epididymitis and epididymo-orchitis without abscess
0.769 0.231 0.000
E14.5 With peripheral circulatory complications
0.000 0.233 0.767
E03 Other hypothyroidism
0.601 0.235 0.164
E10.6 With other specified complications
0.000 0.236 0.764
E11 Non-insulin-dependent diabetes mellitus
0.000 0.239 0.761
N48.3 Priapism
0.725 0.275 0.000
E14.2 Withrenal complications
0.000 0.279 0.721
E51 Thiamine deficiency
0.000 0.280 0.720
E11.3 With ophthalmic complications
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.284 0.716
E14.0 With coma
0.000 0.284 0.716
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.284 0.716
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.284 0.716
E16.4 Abnormal secretion of gastrin
0.000 0.284 0.716
E16.3 Increased secretion of glucagon
0.000 0.284 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.284 0.715
N45.0 Orchitis, epididymitis and epididymo-orchitis with abscess
0.709 0.291 0.000
N51 Disorders of male genital organs in diseases classified elsewhere
0.705 0.295 0.000
D07.1 Vulva
0.704 0.296 0.000
E14.1 With ketoacidosis
0.000 0.298 0.702
N42 Other disorders of prostate
0.698 0.302 0.000
D07 Carcinoma in situ of other and unspecified genital organs
0.697 0.303 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.307 0.693
N48.4 Impotence of organic origin
0.692 0.308 0.000
D00-D09 In situ neoplasms
0.691 0.309 0.000
E06 Thyroiditis
0.001 0.316 0.682
D06 Carcinoma in situ of cervix uteri
0.682 0.318 0.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.322 0.678
E14.4 With neurological complications
0.000 0.327 0.672
D06.9 Cervix, unspecified
0.670 0.330 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.343 0.657
E63 Other nutritional deficiencies
0.000 0.343 0.657
E50 Vitamin A deficiency
0.000 0.343 0.657
E60 Dietary zinc deficiency
0.000 0.343 0.657
E59 Dietary selenium deficiency
0.000 0.343 0.657
E54 Ascorbic acid deficiency
0.000 0.343 0.657
E52 Niacin deficiency [pellagra]
0.000 0.343 0.657
D07.4 Penis
0.645 0.355 0.000
N49 Inflammatory disorders of male genital organs, not elsewhere classified
0.643 0.356 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.002 0.362 0.636
E55.0 Rickets, active
0.000 0.363 0.637
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.002 0.363 0.635
E00 Congenital iodine-deficiency syndrome
0.002 0.363 0.635
E46 Unspecified protein-energy malnutrition
0.000 0.364 0.636
D04 Carcinoma in situ of skin
0.628 0.372 0.000
N41 Inflammatory diseases of prostate
0.624 0.376 0.000
L90.9 Atrophic disorder of skin, unspecified
0.623 0.377 0.000
L90.8 Other atrophic disorders of skin
0.623 0.377 0.000
L90.6 Striae atrophicae
0.623 0.377 0.000
L90.4 Acrodermatitis chronica atrophicans
0.623 0.377 0.000
L90.3 Atrophoderma of Pasini and Pierini
0.623 0.377 0.000
L90.2 Anetoderma of Jadassohn-Pellizzari
0.623 0.377 0.000
L90.1 Anetoderma of Schweninger-Buzzi
0.623 0.377 0.000
J45 Asthma
0.620 0.380 0.000
E07 Other disorders of thyroid
0.002 0.382 0.617
E58 Dietary calcium deficiency
0.000 0.393 0.607
E05.5 Thyroid crisis or storm
0.001 0.398 0.601
E05.4 Thyrotoxicosis factitia
0.001 0.398 0.601
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.001 0.398 0.601
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.001 0.398 0.601
E56 Other vitamin deficiencies
0.000 0.405 0.595
E11.2 With renal complications
0.000 0.412 0.588
E53 Deficiency of other B group vitamins
0.000 0.414 0.586
D04.7 Skin of lower limb, including hip
0.581 0.419 0.000
D09 Carcinoma in situ of other and unspecified sites
0.579 0.421 0.000
E51.2 Wernicke's encephalopathy
0.000 0.422 0.578
E11.8 With unspecified complications
0.000 0.423 0.577
N42.9 Disorder of prostate, unspecified
0.575 0.425 0.000
D03 Melanoma in situ
0.575 0.425 0.000
D01 Carcinoma in situ of other and unspecified digestive organs
0.567 0.433 0.000
D04.9 Skin, unspecified
0.565 0.435 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.435 0.564
E45 Retarded development following protein-energy malnutrition
0.000 0.435 0.564
E43 Unspecified severe protein-energy malnutrition
0.000 0.435 0.564
E42 Marasmic kwashiorkor
0.000 0.435 0.564
E41 Nutritional marasmus
0.000 0.435 0.564
E40 Kwashiorkor
0.000 0.435 0.564
E11.0 With coma
0.000 0.441 0.559
E03.1 Congenital hypothyroidism without goitre
0.451 0.441 0.108
E11.1 With ketoacidosis
0.000 0.443 0.557
E16.1 Other hypoglycaemia
0.000 0.444 0.556
D02 Carcinoma in situ of middle ear and respiratory system
0.549 0.450 0.000
E03.5 Myxoedema coma
0.431 0.452 0.118
E03.4 Atrophy of thyroid (acquired)
0.431 0.452 0.118
E03.3 Postinfectious hypothyroidism
0.431 0.452 0.118
N90 Other noninflammatory disorders of vulva and perineum
0.547 0.453 0.000
E61 Deficiency of other nutrient elements
0.000 0.453 0.547
E11.7 With multiple complications
0.000 0.454 0.546
E11.5 With peripheral circulatory complications
0.000 0.454 0.546
N90.4 Leukoplakia of vulva
0.546 0.454 0.000
D06.0 Endocervix
0.545 0.455 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.443 0.456 0.101
E03.0 Congenital hypothyroidism with diffuse goitre
0.428 0.458 0.115
D03.2 Melanoma in situ of ear and external auricular canal
0.538 0.462 0.000
E07.8 Other specified disorders of thyroid
0.001 0.463 0.536
D06.1 Exocervix
0.536 0.464 0.000
E06.9 Thyroiditis, unspecified
0.001 0.465 0.535
D04.3 Skin of other and unspecified parts of face
0.529 0.471 0.000
E03.8 Other specified hypothyroidism
0.434 0.473 0.092
N90.7 Vulvar cyst
0.526 0.474 0.000
N46 Male infertility
0.523 0.476 0.000
N42.8 Other specified disorders of prostate
0.522 0.478 0.000
N42.1 Congestion and haemorrhage of prostate
0.522 0.478 0.000
E06.3 Autoimmune thyroiditis
0.000 0.482 0.518
J45.0 Predominantly allergic asthma
0.518 0.482 0.000
N41.0 Acute prostatitis
0.517 0.483 0.000
E51.9 Thiamine deficiency, unspecified
0.000 0.484 0.516
E51.8 Other manifestations of thiamine deficiency
0.000 0.484 0.516
E51.1 Beriberi
0.000 0.484 0.516
E04 Other non-toxic goitre
0.000 0.484 0.515
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
N90.8 Other specified noninflammatory disorders of vulva and perineum
0.509 0.491 0.000
D09.1 Other and unspecified urinary organs
0.507 0.493 0.000
N51.8 Other disorders of male genital organs in diseases classified elsewhere
0.505 0.494 0.000
N51.1 Disorders of testis and epididymis in diseases classified elsewhere
0.505 0.494 0.000
N51.0 Disorders of prostate in diseases classified elsewhere
0.505 0.494 0.000
E11.6 With other specified complications
0.000 0.496 0.504
N42.3 Dysplasia of prostate
0.500 0.500 0.000
D07.6 Other and unspecified male genital organs
0.500 0.500 0.000
D07.3 Other and unspecified female genital organs
0.500 0.500 0.000
D07.0 Endometrium
0.500 0.500 0.000
N51.2 Balanitis in diseases classified elsewhere
0.496 0.503 0.000
D04.4 Skin of scalp and neck
0.490 0.510 0.000
E06.4 Drug-induced thyroiditis
0.001 0.510 0.489
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.001 0.510 0.489
E06.1 Subacute thyroiditis
0.001 0.510 0.489
E06.0 Acute thyroiditis
0.001 0.510 0.489
D06.7 Other parts of cervix
0.489 0.511 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.512 0.488
D01.3 Anus and anal canal
0.486 0.514 0.000
N90.9 Noninflammatory disorder of vulva and perineum, unspecified
0.486 0.514 0.000
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.486 0.514 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.516 0.483
E05.8 Other thyrotoxicosis
0.001 0.519 0.481
N90.3 Dysplasia of vulva, unspecified
0.481 0.519 0.000
N90.1 Moderate vulvar dysplasia
0.480 0.520 0.000
E04.0 Non-toxic diffuse goitre
0.000 0.522 0.478
E13 Other specified diabetes mellitus
0.001 0.526 0.474
E50.9 Vitamin A deficiency, unspecified
0.000 0.529 0.471
E50.8 Other manifestations of vitamin A deficiency
0.000 0.529 0.471
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.529 0.471
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.529 0.471
E50.5 Vitamin A deficiency with night blindness
0.000 0.529 0.471
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.529 0.471
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.529 0.471
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.529 0.471
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.529 0.471
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.529 0.471
E63.9 Nutritional deficiency, unspecified
0.000 0.529 0.471
E63.8 Other specified nutritional deficiencies
0.000 0.529 0.471
E63.1 Imbalance of constituents of food intake
0.000 0.529 0.471
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.529 0.471
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.529 0.471
E64.8 Sequelae of other nutritional deficiencies
0.000 0.529 0.471
E64.3 Sequelae of rickets
0.000 0.529 0.471
E64.2 Sequelae of vitamin C deficiency
0.000 0.529 0.471
E64.1 Sequelae of vitamin A deficiency
0.000 0.529 0.471
E64.0 Sequelae of protein-energy malnutrition
0.000 0.529 0.471
J45.8 Mixed asthma
0.470 0.530 0.000
D09.7 Carcinoma in situ of other specified sites
0.469 0.531 0.000
D07.2 Vagina
0.468 0.532 0.000
J45.1 Nonallergic asthma
0.466 0.534 0.000
N42.2 Atrophy of prostate
0.465 0.535 0.000
N49.9 Inflammatory disorder of unspecified male genital organ
0.461 0.538 0.000
N49.1 Inflammatory disorders of spermatic cord, tunica vaginalis and vas deferens
0.461 0.538 0.000
N49.0 Inflammatory disorders of seminal vesicle
0.461 0.538 0.000
E06.5 Other chronic thyroiditis
0.001 0.540 0.459
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.002 0.543 0.455
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.002 0.543 0.455
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.002 0.543 0.455
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.002 0.543 0.455
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.002 0.543 0.455
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.002 0.543 0.455
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.002 0.543 0.455
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.002 0.543 0.455
N41.1 Chronic prostatitis
0.455 0.545 0.000
D03.5 Melanoma in situ of trunk
0.453 0.547 0.000
D03.8 Melanoma in situ of other sites
0.453 0.547 0.000
E53.9 Vitamin B deficiency, unspecified
0.000 0.548 0.452
D04.8 Skin of other sites
0.450 0.550 0.000
D04.0 Skin of lip
0.450 0.550 0.000
N41.3 Prostatocystitis
0.448 0.552 0.000
N41.2 Abscess of prostate
0.448 0.552 0.000
H36 Retinal disorders in diseases classified elsewhere
0.000 0.556 0.444
E07.1 Dyshormogenetic goitre
0.001 0.557 0.442
E07.0 Hypersecretion of calcitonin
0.001 0.557 0.442
N90.0 Mild vulvar dysplasia
0.441 0.559 0.000
D02.0 Larynx
0.435 0.565 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.566 0.434
N49.8 Inflammatory disorders of other specified male genital organs
0.431 0.569 0.000
N49.2 Inflammatory disorders of scrotum
0.427 0.573 0.000
E56.9 Vitamin deficiency, unspecified
0.000 0.573 0.427
E56.8 Deficiency of other vitamins
0.000 0.573 0.427
E56.0 Deficiency of vitamin E
0.000 0.573 0.427
E53.1 Pyridoxine deficiency
0.000 0.580 0.420
E53.0 Riboflavin deficiency
0.000 0.580 0.420
E11.4 With neurological complications
0.000 0.581 0.419
D03.6 Melanoma in situ of upper limb, including shoulder
0.417 0.583 0.000
N41.8 Other inflammatory diseases of prostate
0.415 0.585 0.000
D09.9 Carcinoma in situ, unspecified
0.415 0.585 0.000
D09.3 Thyroid and other endocrine glands
0.415 0.585 0.000
D09.2 Eye
0.415 0.585 0.000
D03.9 Melanoma in situ, unspecified
0.412 0.588 0.000
D03.1 Melanoma in situ of eyelid, including canthus
0.412 0.588 0.000
D03.0 Melanoma in situ of lip
0.412 0.588 0.000
E27 Other disorders of adrenal gland
0.000 0.588 0.412
D02.2 Bronchus and lung
0.412 0.588 0.000
D04.1 Skin of eyelid, including canthus
0.411 0.589 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.592 0.408
E65-E68 Obesity and other hyperalimentation
0.000 0.593 0.407
D01.9 Digestive organ, unspecified
0.406 0.593 0.000
D01.7 Other specified digestive organs
0.406 0.593 0.000
D01.5 Liver, gallbladder and bile ducts
0.406 0.593 0.000
D01.4 Other and unspecified parts of intestine
0.406 0.593 0.000
D01.2 Rectum
0.406 0.593 0.000
D01.1 Rectosigmoid junction
0.406 0.593 0.000
E44.1 Mild protein-energy malnutrition
0.000 0.595 0.405
E44.0 Moderate protein-energy malnutrition
0.000 0.595 0.405
N43 Hydrocele and spermatocele
0.400 0.600 0.000
D02.4 Respiratory system, unspecified
0.394 0.606 0.000
D02.3 Other parts of respiratory system
0.394 0.606 0.000
D02.1 Trachea
0.394 0.606 0.000
N90.2 Severe vulvar dysplasia, not elsewhere classified
0.392 0.607 0.000
E61.9 Deficiency of nutrient element, unspecified
0.000 0.608 0.392
E61.8 Deficiency of other specified nutrient elements
0.000 0.608 0.392
E61.7 Deficiency of multiple nutrient elements
0.000 0.608 0.392
E61.6 Vanadium deficiency
0.000 0.608 0.392
E61.5 Molybdenum deficiency
0.000 0.608 0.392
E61.4 Chromium deficiency
0.000 0.608 0.392
E61.3 Manganese deficiency
0.000 0.608 0.392
E61.0 Copper deficiency
0.000 0.608 0.392
E61.2 Magnesium deficiency
0.000 0.610 0.390
N30.2 Other chronic cystitis
0.390 0.610 0.000
D01.0 Colon
0.389 0.611 0.000
G37 Other demyelinating diseases of central nervous system
0.000 0.616 0.384
N30 Cystitis
0.380 0.620 0.000
D03.7 Melanoma in situ of lower limb, including hip
0.377 0.623 0.000
N90.6 Hypertrophy of vulva
0.375 0.625 0.000
N30.1 Interstitial cystitis (chronic)
0.371 0.629 0.000
E04.8 Other specified non-toxic goitre
0.000 0.630 0.369
E56.1 Deficiency of vitamin K
0.000 0.635 0.364
E34 Other endocrine disorders
0.000 0.636 0.364
D04.2 Skin of ear and external auricular canal
0.364 0.636 0.000
E27.8 Other specified disorders of adrenal gland
0.000 0.640 0.360
N30.0 Acute cystitis
0.359 0.641 0.000
D00.0 Lip, oral cavity and pharynx
0.354 0.646 0.000
G36 Other acute disseminated demyelination
0.000 0.650 0.350
D00.2 Stomach
0.348 0.652 0.000
D04.5 Skin of trunk
0.346 0.654 0.000
E13.8 With unspecified complications
0.001 0.660 0.340
E13.7 With multiple complications
0.001 0.660 0.340
E13.6 With other specified complications
0.001 0.660 0.340
E13.5 With peripheral circulatory complications
0.001 0.660 0.340
E13.4 With neurological complications
0.001 0.660 0.340
E13.2 With renal complications
0.001 0.660 0.340
E13.1 With ketoacidosis
0.001 0.660 0.340
E13.0 With coma
0.001 0.660 0.340
D00.1 Oesophagus
0.332 0.668 0.000
E70-E90 Metabolic disorders
0.000 0.670 0.330
N42.0 Calculus of prostate
0.328 0.672 0.000
E28 Ovarian dysfunction
0.000 0.674 0.326
E13.3 With ophthalmic complications
0.001 0.675 0.325
E83.1 Disorders of iron metabolism
0.000 0.677 0.323
N30.4 Irradiation cystitis
0.319 0.681 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.682 0.318
E83 Disorders of mineral metabolism
0.000 0.682 0.318
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.689 0.311
E32 Diseases of thymus
0.000 0.689 0.311
E31 Polyglandular dysfunction
0.000 0.689 0.311
E30 Disorders of puberty, not elsewhere classified
0.000 0.689 0.311
N43.2 Other hydrocele
0.311 0.689 0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.690 0.310
D09.0 Bladder
0.309 0.691 0.000
N30.3 Trigonitis
0.306 0.694 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.696 0.304
N43.1 Infected hydrocele
0.300 0.700 0.000
E87.7 Fluid overload
0.000 0.701 0.299
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.704 0.296
E27.5 Adrenomedullary hyperfunction
0.000 0.704 0.296
E27.0 Other adrenocortical overactivity
0.000 0.704 0.296
E04.2 Non-toxic multinodular goitre
0.000 0.704 0.296
D03.4 Melanoma in situ of scalp and neck
0.293 0.706 0.000
E34.0 Carcinoid syndrome
0.000 0.707 0.293
E53.8 Deficiency of other specified B group vitamins
0.000 0.707 0.293
E67 Other hyperalimentation
0.000 0.708 0.292
E68 Sequelae of hyperalimentation
0.000 0.708 0.292
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.711 0.289
N43.0 Encysted hydrocele
0.287 0.713 0.000
E61.1 Iron deficiency
0.000 0.715 0.285
E04.9 Non-toxic goitre, unspecified
0.000 0.716 0.284
E26 Hyperaldosteronism
0.000 0.718 0.282
E34.9 Endocrine disorder, unspecified
0.000 0.718 0.282
E20 Hypoparathyroidism
0.000 0.720 0.280
G37.5 Concentric sclerosis [Balo]
0.000 0.725 0.275
G37.4 Subacute necrotising myelitis
0.000 0.725 0.275
G37.2 Central pontine myelinolysis
0.000 0.725 0.275
G37.1 Central demyelination of corpus callosum
0.000 0.725 0.275
G37.0 Diffuse sclerosis
0.000 0.725 0.275
E34.8 Other specified endocrine disorders
0.000 0.727 0.273
E22 Hyperfunction of pituitary gland
0.000 0.729 0.271
N30.8 Other cystitis
0.271 0.729 0.000
E25 Adrenogenital disorders
0.000 0.731 0.269
E87.5 Hyperkalaemia
0.000 0.737 0.263
K90 Intestinal malabsorption
0.000 0.738 0.262
E34.5 Androgen resistance syndrome
0.000 0.739 0.261
E34.4 Constitutional tall stature
0.000 0.739 0.261
E34.3 Short stature, not elsewhere classified
0.000 0.739 0.261
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.739 0.261
E34.1 Other hypersecretion of intestinal hormones
0.000 0.739 0.261
E65 Localised adiposity
0.000 0.739 0.260
E29 Testicular dysfunction
0.000 0.741 0.259
D03.3 Melanoma in situ of other and unspecified parts of face
0.259 0.741 0.000
N90.5 Atrophy of vulva
0.259 0.741 0.000
E23 Hypofunction and other disorders of pituitary gland
0.000 0.743 0.257
E27.9 Disorder of adrenal gland, unspecified
0.000 0.744 0.256
E83.4 Disorders of magnesium metabolism
0.000 0.749 0.251
E28.2 Polycystic ovarian syndrome
0.000 0.749 0.251
D04.6 Skin of upper limb, including shoulder
0.251 0.749 0.000
G36.9 Acute disseminated demyelination, unspecified
0.000 0.749 0.251
G36.8 Other specified acute disseminated demyelination
0.000 0.749 0.251
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.749 0.251
G36.0 Neuromyelitis optica [Devic]
0.000 0.749 0.251
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.750 0.250
E79 Disorders of purine and pyrimidine metabolism
0.000 0.756 0.243
E84 Cystic fibrosis
0.000 0.762 0.238
N41.9 Inflammatory disease of prostate, unspecified
0.237 0.763 0.000
E77 Disorders of glycoprotein metabolism
0.000 0.764 0.236
E76 Disorders of glycosaminoglycan metabolism
0.000 0.764 0.236
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.764 0.236
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.764 0.236
E73 Lactose intolerance
0.000 0.764 0.236
E27.2 Addisonian crisis
0.000 0.766 0.234
E28.9 Ovarian dysfunction, unspecified
0.000 0.766 0.234
E28.8 Other ovarian dysfunction
0.000 0.766 0.234
E28.1 Androgen excess
0.000 0.766 0.234
E28.0 Oestrogen excess
0.000 0.766 0.234
E28.3 Primary ovarian failure
0.000 0.771 0.229
E83.8 Other disorders of mineral metabolism
0.000 0.772 0.228
E83.2 Disorders of zinc metabolism
0.000 0.772 0.228
E83.0 Disorders of copper metabolism
0.000 0.772 0.228
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.772 0.228
E72 Other disorders of amino-acid metabolism
0.000 0.775 0.225
E30.9 Disorder of puberty, unspecified
0.000 0.776 0.223
E30.8 Other disorders of puberty
0.000 0.776 0.223
E30.1 Precocious puberty
0.000 0.776 0.223
E30.0 Delayed puberty
0.000 0.776 0.223
E31.9 Polyglandular dysfunction, unspecified
0.000 0.776 0.223
E31.8 Other polyglandular dysfunction
0.000 0.776 0.223
E31.1 Polyglandular hyperfunction
0.000 0.776 0.223
E31.0 Autoimmune polyglandular failure
0.000 0.776 0.223
E32.9 Disease of thymus, unspecified
0.000 0.776 0.223
E32.8 Other diseases of thymus
0.000 0.776 0.223
E32.1 Abscess of thymus
0.000 0.776 0.223
E32.0 Persistent hyperplasia of thymus
0.000 0.776 0.223
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.776 0.223
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.776 0.223
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.776 0.223
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.779 0.221
E70 Disorders of aromatic amino-acid metabolism
0.000 0.781 0.219
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.781 0.218
E87.4 Mixed disorder of acid-base balance
0.000 0.781 0.218
E23.7 Disorder of pituitary gland, unspecified
0.000 0.784 0.216
E88 Other metabolic disorders
0.000 0.790 0.210
E67.8 Other specified hyperalimentation
0.000 0.790 0.210
E67.3 Hypervitaminosis D
0.000 0.790 0.210
E67.2 Megavitamin-B6 syndrome
0.000 0.790 0.210
E67.1 Hypercarotenaemia
0.000 0.790 0.210
E67.0 Hypervitaminosis A
0.000 0.790 0.210
N43.4 Spermatocele
0.208 0.792 0.000
E22.1 Hyperprolactinaemia
0.000 0.797 0.202
E07.9 Disorder of thyroid, unspecified
0.001 0.798 0.201
E26.9 Hyperaldosteronism, unspecified
0.000 0.798 0.202
E26.8 Other hyperaldosteronism
0.000 0.798 0.202
E26.1 Secondary hyperaldosteronism
0.000 0.798 0.202
E20.8 Other hypoparathyroidism
0.000 0.799 0.201
E20.1 Pseudohypoparathyroidism
0.000 0.799 0.201
E20.0 Idiopathic hypoparathyroidism
0.000 0.799 0.201
E22.0 Acromegaly and pituitary gigantism
0.000 0.800 0.200
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.802 0.198
E74 Other disorders of carbohydrate metabolism
0.000 0.803 0.197
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.804 0.196
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.805 0.195
E22.8 Other hyperfunction of pituitary gland
0.000 0.805 0.195
E25.9 Adrenogenital disorder, unspecified
0.000 0.807 0.193
E25.8 Other adrenogenital disorders
0.000 0.807 0.193
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.810 0.190
K90.3 Pancreatic steatorrhoea
0.000 0.812 0.188
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.812 0.188
K90.1 Tropical sprue
0.000 0.812 0.188
E29.8 Other testicular dysfunction
0.000 0.814 0.186
E29.0 Testicular hyperfunction
0.000 0.814 0.186
E23.6 Other disorders of pituitary gland
0.000 0.814 0.186
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.815 0.184
E23.1 Drug-induced hypopituitarism
0.000 0.815 0.184
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.818 0.182
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.818 0.182
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.825 0.175
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.825 0.175
E79.1 Lesch-Nyhan syndrome
0.000 0.825 0.175
E26.0 Primary hyperaldosteronism
0.000 0.827 0.173
E84.9 Cystic fibrosis, unspecified
0.000 0.828 0.172
E84.8 Cystic fibrosis with other manifestations
0.000 0.829 0.171
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.829 0.171
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.829 0.171
E71.3 Disorders of fatty-acid metabolism
0.000 0.830 0.170
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.830 0.170
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.830 0.170
E71.0 Maple-syrup-urine disease
0.000 0.830 0.170
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.830 0.170
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.830 0.170
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.830 0.170
E76.2 Other mucopolysaccharidoses
0.000 0.830 0.170
E76.1 Mucopolysaccharidosis, type II
0.000 0.830 0.170
E76.0 Mucopolysaccharidosis, type I
0.000 0.830 0.170
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.830 0.170
E77.8 Other disorders of glycoprotein metabolism
0.000 0.830 0.170
E77.1 Defects in glycoprotein degradation
0.000 0.830 0.170
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.830 0.170
E20.9 Hypoparathyroidism, unspecified
0.000 0.830 0.169
E73.8 Other lactose intolerance
0.000 0.831 0.169
E73.1 Secondary lactase deficiency
0.000 0.831 0.169
E73.0 Congenital lactase deficiency
0.000 0.831 0.169
D07.5 Prostate
0.168 0.832 0.000
E29.9 Testicular dysfunction, unspecified
0.000 0.832 0.168
E73.9 Lactose intolerance, unspecified
0.000 0.832 0.168
K90.8 Other intestinal malabsorption
0.000 0.835 0.165
E87.2 Acidosis
0.000 0.837 0.163
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.839 0.161
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.839 0.161
E72.5 Disorders of glycine metabolism
0.000 0.839 0.161
E72.4 Disorders of ornithine metabolism
0.000 0.839 0.161
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.839 0.161
E72.2 Disorders of urea cycle metabolism
0.000 0.839 0.161
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.839 0.161
E29.1 Testicular hypofunction
0.000 0.841 0.159
E89.0 Postprocedural hypothyroidism
0.000 0.841 0.159
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.842 0.158
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.843 0.157
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.843 0.157
E70.2 Disorders of tyrosine metabolism
0.000 0.843 0.157
E70.1 Other hyperphenylalaninaemias
0.000 0.843 0.157
E70.0 Classical phenylketonuria
0.000 0.843 0.157

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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