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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2859448
log Bayes Factor = 73.7242
Chromosome 6   position 31,436,273  (GRCh37) Explore rs2859448 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.001 0.999
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
E05.9 Thyrotoxicosis, unspecified
0.000 0.002 0.998
E70-E90 Metabolic disorders
0.000 0.003 0.997
E14.9 Without complications
0.000 0.005 0.995
E11 Non-insulin-dependent diabetes mellitus
0.000 0.005 0.995
E11.9 Without complications
0.000 0.006 0.994
E10.1 With ketoacidosis
0.000 0.007 0.993
E78.2 Mixed hyperlipidaemia
0.000 0.021 0.979
E10.4 With neurological complications
0.000 0.026 0.974
M45 Ankylosing spondylitis
0.966 0.034 0.000
E07 Other disorders of thyroid
0.000 0.036 0.964
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.958 0.042 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.058 0.942
M75.0 Adhesive capsulitis of shoulder
0.000 0.061 0.939
G35-G37 Demyelinating diseases of the central nervous system
0.935 0.065 0.000
G37 Other demyelinating diseases of central nervous system
0.921 0.079 0.000
E83.1 Disorders of iron metabolism
0.921 0.079 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.097 0.903
E14.3 With ophthalmic complications
0.000 0.114 0.886
G37.9 Demyelinating disease of central nervous system, unspecified
0.883 0.117 0.000
E78.8 Other disorders of lipoprotein metabolism
0.000 0.119 0.881
E11.5 With peripheral circulatory complications
0.000 0.120 0.880
E10.2 With renal complications
0.000 0.121 0.879
E13 Other specified diabetes mellitus
0.000 0.125 0.875
E10.0 With coma
0.000 0.162 0.838
E10.6 With other specified complications
0.000 0.173 0.827
E10.8 With unspecified complications
0.000 0.173 0.827
E74 Other disorders of carbohydrate metabolism
0.000 0.195 0.805
E13.9 Without complications
0.000 0.197 0.803
G37.8 Other specified demyelinating diseases of central nervous system
0.802 0.198 0.000
E88 Other metabolic disorders
0.000 0.200 0.800
E78.4 Other hyperlipidaemia
0.000 0.207 0.793
E14.8 With unspecified complications
0.000 0.215 0.785
E14.1 With ketoacidosis
0.000 0.225 0.775
E78.6 Lipoprotein deficiency
0.000 0.227 0.773
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.772 0.228 0.000
E11.0 With coma
0.000 0.233 0.767
E14.5 With peripheral circulatory complications
0.000 0.239 0.761
E79 Disorders of purine and pyrimidine metabolism
0.000 0.241 0.759
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.249 0.751
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.250 0.750
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.262 0.738
E11.6 With other specified complications
0.000 0.268 0.732
M45.X6 Ankylosing spondylitis (Lumbar region)
0.730 0.270 0.000
E40-E46 Malnutrition
0.000 0.273 0.727
E03.8 Other specified hypothyroidism
0.000 0.278 0.722
E14.4 With neurological complications
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.284 0.716
E14.2 Withrenal complications
0.000 0.284 0.716
E14.0 With coma
0.000 0.284 0.716
E77 Disorders of glycoprotein metabolism
0.000 0.285 0.715
E76 Disorders of glycosaminoglycan metabolism
0.000 0.285 0.715
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.285 0.715
E70 Disorders of aromatic amino-acid metabolism
0.000 0.285 0.715
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.285 0.715
E05.8 Other thyrotoxicosis
0.000 0.286 0.714
E11.7 With multiple complications
0.000 0.287 0.713
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.294 0.706
E88.2 Lipomatosis, not elsewhere classified
0.000 0.303 0.697
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.304 0.696
E10.5 With peripheral circulatory complications
0.000 0.307 0.693
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.692 0.307 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.692 0.307 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.692 0.307 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.692 0.307 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.692 0.307 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.692 0.307 0.000
E07.1 Dyshormogenetic goitre
0.000 0.308 0.691
E07.0 Hypersecretion of calcitonin
0.000 0.308 0.691
E85 Amyloidosis
0.000 0.308 0.691
E73 Lactose intolerance
0.000 0.313 0.687
E72 Other disorders of amino-acid metabolism
0.000 0.319 0.680
G36 Other acute disseminated demyelination
0.678 0.322 0.000
E03.1 Congenital hypothyroidism without goitre
0.000 0.337 0.663
G37.5 Concentric sclerosis [Balo]
0.660 0.340 0.000
G37.4 Subacute necrotising myelitis
0.660 0.340 0.000
G37.2 Central pontine myelinolysis
0.660 0.340 0.000
G37.1 Central demyelination of corpus callosum
0.660 0.340 0.000
G37.0 Diffuse sclerosis
0.660 0.340 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.659 0.340 0.000
E11.1 With ketoacidosis
0.000 0.341 0.659
E07.8 Other specified disorders of thyroid
0.000 0.341 0.659
E84 Cystic fibrosis
0.000 0.349 0.650
E89.3 Postprocedural hypopituitarism
0.000 0.357 0.643
E20-E35 Disorders of other endocrine glands
0.000 0.359 0.641
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.359 0.640
E11.2 With renal complications
0.000 0.365 0.635
E14.6 With other specified complications
0.000 0.367 0.633
E89.2 Postprocedural hypoparathyroidism
0.000 0.370 0.630
E13.8 With unspecified complications
0.000 0.372 0.627
E13.7 With multiple complications
0.000 0.372 0.627
E13.6 With other specified complications
0.000 0.372 0.627
E13.5 With peripheral circulatory complications
0.000 0.372 0.627
E13.4 With neurological complications
0.000 0.372 0.627
E13.2 With renal complications
0.000 0.372 0.627
E13.1 With ketoacidosis
0.000 0.372 0.627
E13.0 With coma
0.000 0.372 0.627
K90 Intestinal malabsorption
0.000 0.375 0.625
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.377 0.623
E88.8 Other specified metabolic disorders
0.000 0.379 0.621
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.403 0.597
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.596 0.404 0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.412 0.588
I83 Varicose veins of lower extremities
0.588 0.412 0.000
I83.0 Varicose veins of lower extremities with ulcer
0.587 0.413 0.000
E78.1 Pure hyperglyceridaemia
0.000 0.414 0.586
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.423 0.577
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.423 0.577
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.423 0.577
E74.2 Disorders of galactose metabolism
0.000 0.423 0.577
E74.1 Disorders of fructose metabolism
0.000 0.423 0.577
E85.9 Amyloidosis, unspecified
0.000 0.428 0.572
E13.3 With ophthalmic complications
0.000 0.431 0.569
E06 Thyroiditis
0.000 0.440 0.559
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.456 0.544
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.456 0.544
E79.1 Lesch-Nyhan syndrome
0.000 0.456 0.544
H20.9 Iridocyclitis, unspecified
0.540 0.460 0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.462 0.538
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.462 0.538
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.462 0.538
E89.5 Postprocedural testicular hypofunction
0.000 0.462 0.538
E89.1 Postprocedural hypoinsulinaemia
0.000 0.462 0.538
E46 Unspecified protein-energy malnutrition
0.000 0.469 0.531
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.479 0.521
E45 Retarded development following protein-energy malnutrition
0.000 0.479 0.521
E43 Unspecified severe protein-energy malnutrition
0.000 0.479 0.521
E42 Marasmic kwashiorkor
0.000 0.479 0.521
E41 Nutritional marasmus
0.000 0.479 0.521
E40 Kwashiorkor
0.000 0.479 0.521
E88.9 Metabolic disorder, unspecified
0.000 0.481 0.519
E88.3 Tumour lysis syndrome
0.000 0.484 0.515
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.487 0.513
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.487 0.513
E70.3 Albinism
0.000 0.487 0.513
E70.2 Disorders of tyrosine metabolism
0.000 0.487 0.513
E70.1 Other hyperphenylalaninaemias
0.000 0.487 0.513
E70.0 Classical phenylketonuria
0.000 0.487 0.513
E71.3 Disorders of fatty-acid metabolism
0.000 0.487 0.513
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.487 0.513
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.487 0.513
E71.0 Maple-syrup-urine disease
0.000 0.487 0.513
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.487 0.513
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.487 0.513
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.487 0.513
E76.2 Other mucopolysaccharidoses
0.000 0.487 0.513
E76.1 Mucopolysaccharidosis, type II
0.000 0.487 0.513
E76.0 Mucopolysaccharidosis, type I
0.000 0.487 0.513
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.487 0.513
E77.8 Other disorders of glycoprotein metabolism
0.000 0.487 0.513
E77.1 Defects in glycoprotein degradation
0.000 0.487 0.513
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.487 0.513
E27 Other disorders of adrenal gland
0.000 0.491 0.509
E65-E68 Obesity and other hyperalimentation
0.000 0.492 0.508
K90.9 Intestinal malabsorption, unspecified
0.000 0.494 0.506
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.496 0.503
E15 Nondiabetic hypoglycaemic coma
0.000 0.501 0.499
E85.8 Other amyloidosis
0.000 0.504 0.496
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.504 0.496
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.504 0.496
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.504 0.496
M75 Shoulder lesions
0.000 0.504 0.496
G36.0 Neuromyelitis optica [Devic]
0.494 0.505 0.000
E73.8 Other lactose intolerance
0.000 0.508 0.492
E73.1 Secondary lactase deficiency
0.000 0.508 0.492
E73.0 Congenital lactase deficiency
0.000 0.508 0.492
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.509 0.491
E74.0 Glycogen storage disease
0.000 0.512 0.488
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.512 0.488
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.512 0.488
E72.5 Disorders of glycine metabolism
0.000 0.512 0.488
E72.4 Disorders of ornithine metabolism
0.000 0.512 0.488
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.512 0.488
E72.2 Disorders of urea cycle metabolism
0.000 0.512 0.488
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.512 0.488
G36.9 Acute disseminated demyelination, unspecified
0.486 0.514 0.000
G36.8 Other specified acute disseminated demyelination
0.486 0.514 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.486 0.514 0.000
I83.1 Varicose veins of lower extremities with inflammation
0.484 0.516 0.000
E89.4 Postprocedural ovarian failure
0.000 0.517 0.483
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.518 0.481
E28 Ovarian dysfunction
0.000 0.520 0.480
E16 Other disorders of pancreatic internal secretion
0.000 0.523 0.477
E22 Hyperfunction of pituitary gland
0.000 0.525 0.475
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.473 0.527 0.000
E27.9 Disorder of adrenal gland, unspecified
0.000 0.528 0.472
E50-E64 Other nutritional deficiencies
0.000 0.529 0.471
E84.8 Cystic fibrosis with other manifestations
0.000 0.533 0.466
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.533 0.466
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.533 0.466
K90.8 Other intestinal malabsorption
0.000 0.535 0.464
E73.9 Lactose intolerance, unspecified
0.000 0.536 0.464
E83 Disorders of mineral metabolism
0.280 0.536 0.184
E23 Hypofunction and other disorders of pituitary gland
0.000 0.540 0.460
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.540 0.460
E32 Diseases of thymus
0.000 0.540 0.460
E31 Polyglandular dysfunction
0.000 0.540 0.460
E30 Disorders of puberty, not elsewhere classified
0.000 0.540 0.460
E25 Adrenogenital disorders
0.000 0.540 0.460
E75.6 Lipid storage disorder, unspecified
0.000 0.540 0.459
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.540 0.459
E75.3 Sphingolipidosis, unspecified
0.000 0.540 0.459
E75.2 Other sphingolipidosis
0.000 0.540 0.459
E75.1 Other gangliosidosis
0.000 0.540 0.459
E75.0 GM2 gangliosidosis
0.000 0.540 0.459
H20 Iridocyclitis
0.458 0.542 0.000
E26 Hyperaldosteronism
0.000 0.545 0.455
M75.4 Impingement syndrome of shoulder
0.000 0.546 0.454
E72.0 Disorders of amino-acid transport
0.000 0.546 0.453
K90.3 Pancreatic steatorrhoea
0.000 0.552 0.448
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.552 0.448
K90.1 Tropical sprue
0.000 0.552 0.448
E20 Hypoparathyroidism
0.000 0.558 0.442
E34 Other endocrine disorders
0.000 0.563 0.437
E85.3 Secondary systemic amyloidosis
0.000 0.566 0.434
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.571 0.429
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.576 0.424
E24 Cushing's syndrome
0.000 0.577 0.423
H20.1 Chronic iridocyclitis
0.421 0.579 0.000
E85.4 Organ-limited amyloidosis
0.000 0.581 0.419
E61 Deficiency of other nutrient elements
0.000 0.589 0.411
E11.3 With ophthalmic complications
0.000 0.590 0.410
E84.9 Cystic fibrosis, unspecified
0.000 0.598 0.402
E06.5 Other chronic thyroiditis
0.000 0.599 0.401
E06.4 Drug-induced thyroiditis
0.000 0.599 0.401
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.599 0.401
E06.1 Subacute thyroiditis
0.000 0.599 0.401
E06.0 Acute thyroiditis
0.000 0.599 0.401
E78.5 Hyperlipidaemia, unspecified
0.000 0.599 0.401
E29 Testicular dysfunction
0.000 0.602 0.398
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.602 0.398
E80.2 Other porphyria
0.001 0.602 0.397
E75.5 Other lipid storage disorders
0.000 0.615 0.385
E16.1 Other hypoglycaemia
0.000 0.616 0.384
M75.2 Bicipital tendinitis
0.000 0.616 0.384
E23.2 Diabetes insipidus
0.000 0.616 0.384
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.617 0.383
E65 Localised adiposity
0.000 0.618 0.382
E28.2 Polycystic ovarian syndrome
0.000 0.621 0.379
E44.1 Mild protein-energy malnutrition
0.000 0.626 0.374
E44.0 Moderate protein-energy malnutrition
0.000 0.626 0.374
E80.1 Porphyria cutanea tarda
0.001 0.627 0.372
E11.8 With unspecified complications
0.001 0.630 0.368
E23.6 Other disorders of pituitary gland
0.000 0.631 0.369
E61.1 Iron deficiency
0.000 0.634 0.366
M75.3 Calcific tendinitis of shoulder
0.000 0.634 0.366
E27.5 Adrenomedullary hyperfunction
0.000 0.635 0.365
E27.0 Other adrenocortical overactivity
0.000 0.635 0.365
E27.8 Other specified disorders of adrenal gland
0.000 0.635 0.365
E67 Other hyperalimentation
0.000 0.636 0.364
E68 Sequelae of hyperalimentation
0.000 0.636 0.364
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.638 0.361
E80.5 Crigler-Najjar syndrome
0.001 0.638 0.361
E80.3 Defects of catalase and peroxydase
0.001 0.638 0.361
E80.0 Hereditary erythropoietic porphyria
0.001 0.638 0.361
H20.0 Acute and subacute iridocyclitis
0.358 0.642 0.000
M75.8 Other shoulder lesions
0.000 0.644 0.355
E22.0 Acromegaly and pituitary gigantism
0.000 0.647 0.353
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.652 0.348
E28.9 Ovarian dysfunction, unspecified
0.000 0.656 0.344
E28.8 Other ovarian dysfunction
0.000 0.656 0.344
E28.1 Androgen excess
0.000 0.656 0.344
E28.0 Oestrogen excess
0.000 0.656 0.344
E06.9 Thyroiditis, unspecified
0.000 0.657 0.343
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.657 0.342
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.657 0.342
E16.4 Abnormal secretion of gastrin
0.000 0.657 0.342
E16.3 Increased secretion of glucagon
0.000 0.657 0.342
E11.4 With neurological complications
0.000 0.657 0.342
E80.6 Other disorders of bilirubin metabolism
0.001 0.659 0.340
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.659 0.340
E22.8 Other hyperfunction of pituitary gland
0.000 0.659 0.340
E23.7 Disorder of pituitary gland, unspecified
0.000 0.660 0.340
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.662 0.337
E63 Other nutritional deficiencies
0.000 0.662 0.337
E51 Thiamine deficiency
0.000 0.662 0.337
E50 Vitamin A deficiency
0.000 0.662 0.337
E60 Dietary zinc deficiency
0.000 0.662 0.337
E59 Dietary selenium deficiency
0.000 0.662 0.337
E54 Ascorbic acid deficiency
0.000 0.662 0.337
E52 Niacin deficiency [pellagra]
0.000 0.662 0.337
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.665 0.335
E21.3 Hyperparathyroidism, unspecified
0.000 0.667 0.333
E83.9 Disorder of mineral metabolism, unspecified
0.201 0.667 0.132
E83.8 Other disorders of mineral metabolism
0.201 0.667 0.132
E83.2 Disorders of zinc metabolism
0.201 0.667 0.132
E83.0 Disorders of copper metabolism
0.201 0.667 0.132
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.670 0.330
E23.1 Drug-induced hypopituitarism
0.000 0.670 0.330
E25.9 Adrenogenital disorder, unspecified
0.000 0.670 0.330
E25.8 Other adrenogenital disorders
0.000 0.670 0.330
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.670 0.330
E30.9 Disorder of puberty, unspecified
0.000 0.670 0.330
E30.8 Other disorders of puberty
0.000 0.670 0.330
E30.1 Precocious puberty
0.000 0.670 0.330
E30.0 Delayed puberty
0.000 0.670 0.330
E31.9 Polyglandular dysfunction, unspecified
0.000 0.670 0.330
E31.8 Other polyglandular dysfunction
0.000 0.670 0.330
E31.1 Polyglandular hyperfunction
0.000 0.670 0.330
E31.0 Autoimmune polyglandular failure
0.000 0.670 0.330
E32.9 Disease of thymus, unspecified
0.000 0.670 0.330
E32.8 Other diseases of thymus
0.000 0.670 0.330
E32.1 Abscess of thymus
0.000 0.670 0.330
E32.0 Persistent hyperplasia of thymus
0.000 0.670 0.330
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.670 0.330
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.670 0.330
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.670 0.330
E34.8 Other specified endocrine disorders
0.000 0.671 0.329
E06.3 Autoimmune thyroiditis
0.000 0.671 0.329
H20.2 Lens-induced iridocyclitis
0.328 0.671 0.000
E26.9 Hyperaldosteronism, unspecified
0.000 0.673 0.326
E26.8 Other hyperaldosteronism
0.000 0.673 0.326
E26.1 Secondary hyperaldosteronism
0.000 0.673 0.326
E28.3 Primary ovarian failure
0.000 0.675 0.325
E34.9 Endocrine disorder, unspecified
0.000 0.675 0.325
E26.0 Primary hyperaldosteronism
0.000 0.678 0.322
E56 Other vitamin deficiencies
0.000 0.679 0.321
E20.8 Other hypoparathyroidism
0.000 0.683 0.317
E20.1 Pseudohypoparathyroidism
0.000 0.683 0.317
E20.0 Idiopathic hypoparathyroidism
0.000 0.683 0.317
E24.2 Drug-induced Cushing's syndrome
0.000 0.683 0.317
E34.5 Androgen resistance syndrome
0.000 0.687 0.313
E34.4 Constitutional tall stature
0.000 0.687 0.313
E34.3 Short stature, not elsewhere classified
0.000 0.687 0.313
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.687 0.313
E34.1 Other hypersecretion of intestinal hormones
0.000 0.687 0.313
E78.9 Disorder of lipoprotein metabolism, unspecified
0.001 0.691 0.308
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.693 0.307
E21.4 Other specified disorders of parathyroid gland
0.000 0.693 0.307
M79.65 Pain in limb (Pelvic region and thigh)
0.000 0.695 0.305
E24.8 Other Cushing's syndrome
0.000 0.696 0.304
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.696 0.304
E24.3 Ectopic ACTH syndrome
0.000 0.696 0.304
E24.1 Nelson's syndrome
0.000 0.696 0.304
E61.2 Magnesium deficiency
0.000 0.698 0.301
E20.9 Hypoparathyroidism, unspecified
0.000 0.701 0.299
E61.9 Deficiency of nutrient element, unspecified
0.000 0.705 0.295
E61.8 Deficiency of other specified nutrient elements
0.000 0.705 0.295
E61.7 Deficiency of multiple nutrient elements
0.000 0.705 0.295
E61.6 Vanadium deficiency
0.000 0.705 0.295
E61.5 Molybdenum deficiency
0.000 0.705 0.295
E61.4 Chromium deficiency
0.000 0.705 0.295
E61.3 Manganese deficiency
0.000 0.705 0.295
E61.0 Copper deficiency
0.000 0.705 0.295
M75.9 Shoulder lesion, unspecified
0.000 0.706 0.294
E83.3 Disorders of phosphorus metabolism
0.238 0.708 0.054
E21.2 Other hyperparathyroidism
0.000 0.708 0.292
E24.0 Pituitary-dependent Cushing's disease
0.000 0.709 0.291
M75.5 Bursitis of shoulder
0.000 0.709 0.291
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.287 0.713 0.000
E29.9 Testicular dysfunction, unspecified
0.000 0.714 0.286
E29.8 Other testicular dysfunction
0.000 0.714 0.286
E29.0 Testicular hyperfunction
0.000 0.714 0.286
E58 Dietary calcium deficiency
0.000 0.717 0.283
E24.9 Cushing's syndrome, unspecified
0.000 0.735 0.264
E89.0 Postprocedural hypothyroidism
0.000 0.737 0.263
E67.8 Other specified hyperalimentation
0.000 0.739 0.261
E67.3 Hypervitaminosis D
0.000 0.739 0.261
E67.2 Megavitamin-B6 syndrome
0.000 0.739 0.261
E67.1 Hypercarotenaemia
0.000 0.739 0.261
E67.0 Hypervitaminosis A
0.000 0.739 0.261
M79.6 Pain in limb
0.000 0.740 0.260
H16 Keratitis
0.260 0.740 0.000
M75.81 Other shoulder lesions, right shoulder
0.000 0.745 0.255
H20.8 Other iridocyclitis
0.255 0.745 0.000
E34.0 Carcinoid syndrome
0.000 0.749 0.250
M70-M79 Other soft tissue disorders
0.000 0.750 0.250
H16.0 Corneal ulcer
0.249 0.751 0.000
H18 Other disorders of cornea
0.247 0.753 0.000
E22.1 Hyperprolactinaemia
0.000 0.754 0.245
E50.9 Vitamin A deficiency, unspecified
0.000 0.758 0.242
E50.8 Other manifestations of vitamin A deficiency
0.000 0.758 0.242
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.758 0.242
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.758 0.242
E50.5 Vitamin A deficiency with night blindness
0.000 0.758 0.242
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.758 0.242
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.758 0.242
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.758 0.242
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.758 0.242
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.758 0.242
E51.9 Thiamine deficiency, unspecified
0.000 0.758 0.242
E51.8 Other manifestations of thiamine deficiency
0.000 0.758 0.242
E51.2 Wernicke's encephalopathy
0.000 0.758 0.242
E51.1 Beriberi
0.000 0.758 0.242
E63.9 Nutritional deficiency, unspecified
0.000 0.758 0.242
E63.8 Other specified nutritional deficiencies
0.000 0.758 0.242
E63.1 Imbalance of constituents of food intake
0.000 0.758 0.242
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.758 0.242
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.758 0.242
E64.8 Sequelae of other nutritional deficiencies
0.000 0.758 0.242
E64.3 Sequelae of rickets
0.000 0.758 0.242
E64.2 Sequelae of vitamin C deficiency
0.000 0.758 0.242
E64.1 Sequelae of vitamin A deficiency
0.000 0.758 0.242
E64.0 Sequelae of protein-energy malnutrition
0.000 0.758 0.242
E27.1 Primary adrenocortical insufficiency
0.000 0.759 0.241
M79 Other soft tissue disorders, not elsewhere classified
0.000 0.761 0.239
M79.63 Pain in limb (Forearm)
0.000 0.767 0.233
E27.2 Addisonian crisis
0.001 0.767 0.232
E56.9 Vitamin deficiency, unspecified
0.000 0.769 0.230
E56.8 Deficiency of other vitamins
0.000 0.769 0.230
E56.0 Deficiency of vitamin E
0.000 0.769 0.230
E55 Vitamin D deficiency
0.000 0.771 0.229
M79.64 Pain in limb (Hand)
0.000 0.776 0.224
E29.1 Testicular hypofunction
0.000 0.776 0.224
H18.1 Bullous keratopathy
0.223 0.777 0.000
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.221 0.778 0.000
E56.1 Deficiency of vitamin K
0.000 0.786 0.214
H16.8 Other keratitis
0.212 0.788 0.000
H18.6 Keratoconus
0.209 0.791 0.000
H18.3 Changes in corneal membranes
0.206 0.794 0.000
M79.62 Pain in limb (Upper arm)
0.000 0.800 0.200
E83.4 Disorders of magnesium metabolism
0.074 0.803 0.123
M77 Other enthesopathies
0.000 0.804 0.196
M79.60 Pain in limb (Multiple sites)
0.000 0.808 0.192
H17 Corneal scars and opacities
0.191 0.809 0.000
H18.5 Hereditary corneal dystrophies
0.189 0.811 0.000
M79.7 Fibromyalgia
0.000 0.811 0.188
H18.2 Other corneal oedema
0.187 0.813 0.000
H16.4 Corneal neovascularisation
0.186 0.813 0.000
H16.3 Interstitial and deep keratitis
0.186 0.814 0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.186 0.814 0.000
H15 Disorders of sclera
0.185 0.815 0.000
M76 Enthesopathies of lower limb, excluding foot
0.000 0.816 0.184
M77.1 Lateral epicondylitis
0.000 0.817 0.183
H16.1 Other superficial keratitis without conjunctivitis
0.180 0.820 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.000 0.820 0.180
H18.7 Other corneal deformities
0.177 0.822 0.000
E53 Deficiency of other B group vitamins
0.000 0.824 0.175
H18.0 Corneal pigmentations and deposits
0.175 0.824 0.000
M79.67 Pain in limb (Ankle and foot)
0.000 0.825 0.175
H22.1 Iridocyclitis in other diseases classified elsewhere
0.175 0.825 0.000
M79.68 Pain in limb (Other)
0.000 0.825 0.174
M77.12 Lateral epicondylitis (Upper arm)
0.000 0.826 0.174
M79.3 Panniculitis, unspecified
0.000 0.829 0.171
M79.61 Pain in limb (Shoulder region)
0.000 0.830 0.170
E21.0 Primary hyperparathyroidism
0.000 0.830 0.169
M79.9 Soft tissue disorder, unspecified
0.000 0.831 0.169
E55.0 Rickets, active
0.000 0.835 0.164
M79.79 Fibromyalgia (Site unspecified)
0.000 0.836 0.164
M79.4 Hypertrophy of (infrapatellar) fat pad
0.000 0.839 0.161
H18.4 Corneal degeneration
0.160 0.840 0.000
H22.8 Other disorders of iris and ciliary body in diseases classified elsewhere
0.159 0.841 0.000
H22.0 Iridocyclitis in infectious and parasitic diseases classified elsewhere
0.159 0.841 0.000
H16.2 Keratoconjunctivitis
0.158 0.842 0.000
E16.2 Hypoglycaemia, unspecified
0.000 0.845 0.155
M79.1 Myalgia
0.000 0.849 0.151
H17.8 Other corneal scars and opacities
0.147 0.853 0.000
H21 Other disorders of iris and ciliary body
0.146 0.854 0.000
M76.8 Other enthesopathies of lower limb, excluding foot
0.000 0.854 0.146
M79.5 Residual foreign body in soft tissue
0.000 0.855 0.145
M77.8 Other enthesopathies, not elsewhere classified
0.000 0.859 0.141
M77.3 Calcaneal spur
0.000 0.859 0.141
M77.2 Periarthritis of wrist
0.000 0.859 0.141
M76.6 Achilles tendinitis
0.000 0.859 0.141
M77.0 Medial epicondylitis
0.000 0.860 0.140

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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