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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs28659842
log Bayes Factor = 12.442
Chromosome 22   position 24,776,451  (GRCh37) Explore rs28659842 on Ensembl!
Variant rs28659842 is part of Cluster X0057

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.999 0.001 0.000
Chapter IX Diseases of the circulatory system
0.998 0.002 0.000
E70-E90 Metabolic disorders
0.998 0.002 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.998 0.002 0.000
I30-I52 Other forms of heart disease
0.995 0.005 0.000
Chapter VIII Diseases of the ear and mastoid process
0.995 0.005 0.000
I34 Nonrheumatic mitral valve disorders
0.994 0.006 0.000
E87.2 Acidosis
0.990 0.010 0.000
Chapter XX External causes of morbidity and mortality
0.990 0.010 0.000
I34.0 Mitral (valve) insufficiency
0.989 0.011 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.987 0.013 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.986 0.014 0.000
Chapter VI Diseases of the nervous system
0.979 0.021 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.978 0.022 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.977 0.023 0.000
I05-I09 Chronic rheumatic heart diseases
0.974 0.026 0.000
E87.5 Hyperkalaemia
0.970 0.030 0.000
Chapter I Certain infectious and parasitic diseases
0.968 0.032 0.000
S00-S09 Injuries to the head
0.964 0.036 0.000
H90-H95 Other disorders of ear
0.954 0.046 0.000
H65-H75 Diseases of middle ear and mastoid
0.952 0.048 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.951 0.049 0.000
S01 Open wound of head
0.948 0.052 0.000
M05-M14 Inflammatory polyarthropathies
0.947 0.053 0.000
M20-M25 Other joint disorders
0.940 0.060 0.000
I05 Rheumatic mitral valve diseases
0.940 0.060 0.000
B95-B98 Bacterial, viral and other infectious agents
0.932 0.068 0.000
T81 Complications of procedures, not elsewhere classified
0.930 0.070 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.924 0.076 0.000
D50-D53 Nutritional anaemias
0.924 0.076 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.924 0.076 0.000
I27 Other pulmonary heart diseases
0.920 0.080 0.000
M25 Other joint disorders, not elsewhere classified
0.918 0.082 0.000
I42 Cardiomyopathy
0.918 0.082 0.000
S40-S49 Injuries to the shoulder and upper arm
0.917 0.083 0.000
Y43 Primarily systemic agents
0.916 0.084 0.000
T81.3 Disruption of operation wound, not elsewhere classified
0.908 0.092 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.903 0.097 0.000
H71 Cholesteatoma of middle ear
0.902 0.098 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.895 0.105 0.000
H92 Otalgia and effusion of ear
0.892 0.108 0.000
G70-G73 Diseases of myoneural junction and muscle
0.890 0.110 0.000
M10 Gout
0.886 0.114 0.000
G90-G99 Other disorders of the nervous system
0.884 0.116 0.000
I34.2 Nonrheumatic mitral (valve) stenosis
0.884 0.116 0.000
M07 Psoriatic and enteropathic arthropathies
0.883 0.117 0.000
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified
0.880 0.120 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.879 0.121 0.000
Chapter X Diseases of the respiratory system
0.878 0.122 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.876 0.124 0.000
S70-S79 Injuries to the hip and thigh
0.875 0.125 0.000
I27.0 Primary pulmonary hypertension
0.875 0.125 0.000
D50 Iron deficiency anaemia
0.874 0.126 0.000
E87.0 Hyperosmolality and hypernatraemia
0.871 0.129 0.000
S01.0 Open wound of scalp
0.870 0.130 0.000
A30-A49 Other bacterial diseases
0.870 0.130 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.869 0.131 0.000
M25.4 Effusion of joint
0.869 0.131 0.000
G40-G47 Episodic and paroxysmal disorders
0.869 0.131 0.000
T18 Foreign body in alimentary tract
0.869 0.131 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.868 0.132 0.000
I05.9 Mitral valve disease, unspecified
0.862 0.138 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.861 0.139 0.000
M35 Other systemic involvement of connective tissue
0.861 0.139 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.859 0.141 0.000
Y43.3 Other antineoplastic drugs
0.855 0.145 0.000
D50.9 Iron deficiency anaemia, unspecified
0.855 0.145 0.000
Chapter XIV Diseases of the genitourinary system
0.854 0.146 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.853 0.147 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.847 0.153 0.000
B95.4 Other streptococcus as the cause of diseases classified to other chapters
0.847 0.153 0.000
N60-N64 Disorders of breast
0.847 0.153 0.000
M10.9 Gout, unspecified
0.843 0.157 0.000
D80-D89 Certain disorders involving the immune mechanism
0.843 0.157 0.000
I46 Cardiac arrest
0.841 0.159 0.000
M07.3 Other psoriatic arthropathies
0.838 0.162 0.000
G30-G32 Other degenerative diseases of the nervous system
0.834 0.166 0.000
I34.1 Mitral (valve) prolapse
0.833 0.167 0.000
H60-H62 Diseases of external ear
0.832 0.168 0.000
H93 Other disorders of ear, not elsewhere classified
0.831 0.169 0.000
S01.9 Open wound of head, part unspecified
0.831 0.169 0.000
T18.1 Foreign body in oesophagus
0.829 0.171 0.000
G40 Epilepsy
0.828 0.172 0.000
M25.5 Pain in joint
0.828 0.172 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.825 0.175 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.824 0.176 0.000
M65-M68 Disorders of synovium and tendon
0.822 0.178 0.000
I31 Other diseases of pericardium
0.821 0.179 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.820 0.179 0.000
H65 Nonsuppurative otitis media
0.820 0.180 0.000
N60 Benign mammary dysplasia
0.816 0.184 0.000
L20-L30 Dermatitis and eczema
0.814 0.186 0.000
A41 Other septicaemia
0.813 0.187 0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters
0.813 0.187 0.000
S60-S69 Injuries to the wrist and hand
0.812 0.188 0.000
S01.3 Open wound of ear
0.812 0.188 0.000
E86 Volume depletion
0.811 0.189 0.000
H92.1 Otorrhoea
0.810 0.190 0.000
I08 Multiple valve diseases
0.809 0.191 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.808 0.192 0.000
E83 Disorders of mineral metabolism
0.808 0.192 0.000
N61 Inflammatory disorders of breast
0.807 0.193 0.000
I42.1 Obstructive hypertrophic cardiomyopathy
0.803 0.197 0.000
N60.1 Diffuse cystic mastopathy
0.801 0.199 0.000
I05.2 Mitral stenosis with insufficiency
0.797 0.203 0.000
M21 Other acquired deformities of limbs
0.795 0.205 0.000
B98 Other specified infectious agents as the cause of diseases classified to other chapters
0.794 0.206 0.000
S20-S29 Injuries to the thorax
0.793 0.207 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.792 0.208 0.000
G70 Myasthenia gravis and other myoneural disorders
0.791 0.209 0.000
J00-J06 Acute upper respiratory infections
0.788 0.212 0.000
I05.0 Mitral stenosis
0.786 0.214 0.000
S40 Superficial injury of shoulder and upper arm
0.785 0.215 0.000
M35.3 Polymyalgia rheumatica
0.784 0.216 0.000
S06 Intracranial injury
0.784 0.216 0.000
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts
0.784 0.216 0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.783 0.217 0.000
Y95 Nosocomial condition
0.782 0.218 0.000
E00-E07 Disorders of thyroid gland
0.780 0.220 0.000
M15-M19 Arthrosis
0.779 0.221 0.000
Y52 Agents primarily affecting the cardiovascular system
0.778 0.222 0.000
M10.99 Gout, unspecified (Site unspecified)
0.778 0.222 0.000
B95.8 Unspecified staphylococcus as the cause of diseases classified to other chapters
0.777 0.223 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.775 0.224 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.775 0.224 0.000
E87.7 Fluid overload
0.774 0.226 0.000
Chapter VII Diseases of the eye and adnexa
0.773 0.227 0.000
J95-J99 Other diseases of the respiratory system
0.773 0.227 0.000
T79-T79 Certain early complications of trauma
0.772 0.228 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.771 0.229 0.000
I10-I15 Hypertensive diseases
0.771 0.229 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.771 0.229 0.000
I33 Acute and subacute endocarditis
0.768 0.232 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.767 0.233 0.000
L40-L45 Papulosquamous disorders
0.766 0.234 0.000
D70 Agranulocytosis
0.764 0.236 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.763 0.237 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.762 0.238 0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified
0.760 0.240 0.000
B15-B19 Viral hepatitis
0.760 0.240 0.000
S01.4 Open wound of cheek and temporomandibular area
0.759 0.241 0.000
Y40 Systemic antibiotics
0.758 0.242 0.000
G93 Other disorders of brain
0.757 0.243 0.000
M80-M85 Disorders of bone density and structure
0.757 0.243 0.000
E88 Other metabolic disorders
0.756 0.244 0.000
H92.0 Otalgia
0.756 0.244 0.000
M19 Other arthrosis
0.756 0.244 0.000
M25.46 Effusion of joint (Lower leg)
0.755 0.245 0.000
D60-D64 Aplastic and other anaemias
0.755 0.245 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.755 0.245 0.000
S01.8 Open wound of other parts of head
0.755 0.245 0.000
X50-X57 Overexertion, travel and privation
0.754 0.245 0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.754 0.246 0.000
T93 Sequelae of injuries of lower limb
0.752 0.248 0.000
E89.0 Postprocedural hypothyroidism
0.750 0.250 0.000
T87 Complications peculiar to reattachment and amputation
0.749 0.251 0.000
S80-S89 Injuries to the knee and lower leg
0.747 0.253 0.000
M25.45 Effusion of joint (Pelvic region and thigh)
0.746 0.254 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.746 0.254 0.000
E40-E46 Malnutrition
0.745 0.255 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.745 0.255 0.000
N17-N19 Renal failure
0.744 0.256 0.000
A41.9 Septicaemia, unspecified
0.744 0.256 0.000
G40.9 Epilepsy, unspecified
0.744 0.256 0.000
H60 Otitis externa
0.743 0.257 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.743 0.257 0.000
V20-V29 Motorcycle rider injured in transport accident
0.743 0.257 0.000
I42.9 Cardiomyopathy, unspecified
0.742 0.258 0.000
Q21 Congenital malformations of cardiac septa
0.742 0.258 0.000
E20-E35 Disorders of other endocrine glands
0.741 0.259 0.000
H74 Other disorders of middle ear and mastoid
0.740 0.260 0.000
I27.9 Pulmonary heart disease, unspecified
0.739 0.261 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.739 0.261 0.000
I30 Acute pericarditis
0.739 0.261 0.000
I07 Rheumatic tricuspid valve diseases
0.738 0.261 0.000
Y42.7 Androgens and anabolic congeners
0.738 0.262 0.000
I27.2 Other secondary pulmonary hypertension
0.737 0.263 0.000
M67 Other disorders of synovium and tendon
0.737 0.263 0.000
J00 Acute nasopharyngitis [common cold]
0.735 0.265 0.000
S62 Fracture at wrist and hand level
0.735 0.265 0.000
M91-M94 Chondropathies
0.734 0.266 0.000
T86 Failure and rejection of transplanted organs and tissues
0.733 0.267 0.000
E73 Lactose intolerance
0.730 0.270 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.729 0.271 0.000
Y43.4 Immunosuppressive agents
0.728 0.272 0.000
M34 Systemic sclerosis
0.728 0.272 0.000
L29 Pruritus
0.727 0.272 0.000
G54 Nerve root and plexus disorders
0.727 0.273 0.000
M06 Other rheumatoid arthritis
0.726 0.274 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.726 0.274 0.000
H90 Conductive and sensorineural hearing loss
0.726 0.274 0.000
S70 Superficial injury of hip and thigh
0.723 0.277 0.000
W20-W49 Exposure to inanimate mechanical forces
0.722 0.278 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.722 0.278 0.000
M25.51 Pain in joint (Shoulder region)
0.721 0.279 0.000
G70.0 Myasthenia gravis
0.720 0.280 0.000
S90-S99 Injuries to the ankle and foot
0.719 0.281 0.000
S10-S19 Injuries to the neck
0.719 0.281 0.000
M31 Other necrotising vasculopathies
0.718 0.282 0.000
G96 Other disorders of central nervous system
0.718 0.282 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.717 0.283 0.000
M25.53 Pain in joint (Forearm)
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.716 0.284 0.000
E85 Amyloidosis
0.716 0.284 0.000
E84 Cystic fibrosis
0.716 0.284 0.000
E79 Disorders of purine and pyrimidine metabolism
0.716 0.284 0.000
E77 Disorders of glycoprotein metabolism
0.716 0.284 0.000
E76 Disorders of glycosaminoglycan metabolism
0.716 0.284 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.716 0.284 0.000
E74 Other disorders of carbohydrate metabolism
0.716 0.284 0.000
E72 Other disorders of amino-acid metabolism
0.716 0.284 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.716 0.284 0.000
E70 Disorders of aromatic amino-acid metabolism
0.716 0.284 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.716 0.284 0.000
H55-H59 Other disorders of eye and adnexa
0.716 0.284 0.000
E87.4 Mixed disorder of acid-base balance
0.715 0.285 0.000
E87.3 Alkalosis
0.715 0.285 0.000
M25.47 Effusion of joint (Ankle and foot)
0.715 0.285 0.000
H66 Suppurative and unspecified otitis media
0.715 0.285 0.000
I52 Other heart disorders in diseases classified elsewhere
0.713 0.287 0.000
I48 Atrial fibrillation and flutter
0.713 0.287 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.713 0.287 0.000
I41 Myocarditis in diseases classified elsewhere
0.713 0.287 0.000
I40 Acute myocarditis
0.713 0.287 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.713 0.287 0.000
I37 Pulmonary valve disorders
0.713 0.287 0.000
I36 Nonrheumatic tricuspid valve disorders
0.713 0.287 0.000
I32 Pericarditis in diseases classified elsewhere
0.713 0.287 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.713 0.287 0.000
X20-X29 Contact with venomous animals and plants
0.713 0.287 0.000
I34.8 Other nonrheumatic mitral valve disorders
0.713 0.287 0.000
S01.5 Open wound of lip and oral cavity
0.712 0.288 0.000
I12 Hypertensive renal disease
0.711 0.289 0.000
M25.0 Haemarthrosis
0.710 0.290 0.000
Y35-Y36 Legal intervention and operations of war
0.710 0.290 0.000
Y10-Y34 Event of undetermined intent
0.710 0.290 0.000
Y00-Y09 Assault
0.710 0.290 0.000
X85-X99 Assault
0.710 0.290 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.710 0.290 0.000
X30-X39 Exposure to forces of nature
0.710 0.290 0.000
X10-X19 Contact with heat and hot substances
0.710 0.290 0.000
X00-X09 Exposure to smoke, fire and flames
0.710 0.290 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.710 0.290 0.000
W75-W84 Other accidental threats to breathing
0.710 0.290 0.000
W65-W74 Accidental drowning and submersion
0.710 0.290 0.000
W50-W64 Exposure to animate mechanical forces
0.710 0.290 0.000
V98-V99 Other and unspecified transport accidents
0.710 0.290 0.000
V95-V97 Air and space transport accidents
0.710 0.290 0.000
V90-V94 Water transport accidents
0.710 0.290 0.000
V70-V79 Bus occupant injured in transport accident
0.710 0.290 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.710 0.290 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.710 0.290 0.000
V40-V49 Car occupant injured in transport accident
0.710 0.290 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.710 0.290 0.000
V01-V09 Pedestrian injured in transport accident
0.710 0.290 0.000
Q00-Q07 Congenital malformations of the nervous system
0.709 0.291 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.708 0.291 0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip
0.708 0.292 0.000
M60-M63 Disorders of muscles
0.708 0.292 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.708 0.292 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.707 0.292 0.000
D55-D59 Haemolytic anaemias
0.707 0.293 0.000
M25.56 Pain in joint (Lower leg)
0.707 0.293 0.000
D52 Folate deficiency anaemia
0.706 0.293 0.000
N10-N16 Renal tubulo-interstitial diseases
0.706 0.294 0.000
Y60 Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care
0.706 0.294 0.000
I38 Endocarditis, valve unspecified
0.706 0.294 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.705 0.295 0.000
M19.0 Primary arthrosis of other joints
0.705 0.295 0.000
T91 Sequelae of injuries of neck and trunk
0.705 0.295 0.000
B35-B49 Mycoses
0.704 0.295 0.000
M00-M03 Infectious arthropathies
0.704 0.296 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.704 0.296 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.703 0.297 0.000
T92 Sequelae of injuries of upper limb
0.702 0.298 0.000
A41.0 Septicaemia due to Staphylococcus aureus
0.701 0.299 0.000
Y59 Other and unspecified vaccines and biological substances
0.701 0.299 0.000
Y58 Bacterial vaccines
0.701 0.299 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.701 0.299 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.701 0.299 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.701 0.299 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.701 0.299 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.701 0.299 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.701 0.299 0.000
Y48 Anaesthetics and therapeutic gases
0.701 0.299 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.701 0.299 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.701 0.299 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.701 0.299 0.000
A80-A89 Viral infections of the central nervous system
0.701 0.299 0.000
I09 Other rheumatic heart diseases
0.698 0.302 0.000
I06 Rheumatic aortic valve diseases
0.698 0.302 0.000
I42.2 Other hypertrophic cardiomyopathy
0.698 0.302 0.000
S50-S59 Injuries to the elbow and forearm
0.698 0.302 0.000
I46.0 Cardiac arrest with successful resuscitation
0.698 0.302 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.697 0.303 0.000
G71 Primary disorders of muscles
0.697 0.303 0.000
V80-V89 Other land transport accidents
0.696 0.304 0.000
B98.0 Helicobacter pylori [H.pylori] as the cause of diseases classified to other chapters
0.696 0.304 0.000
M25.8 Other specified joint disorders
0.696 0.304 0.000
Y42.5 Other oestrogens and progestogens
0.694 0.305 0.000
B99-B99 Other infectious diseases
0.694 0.306 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.694 0.306 0.000
B65-B83 Helminthiases
0.694 0.306 0.000
B50-B64 Protozoal diseases
0.694 0.306 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.694 0.306 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.694 0.306 0.000
A75-A79 Rickettsioses
0.694 0.306 0.000
A70-A74 Other diseases caused by chlamydiae
0.694 0.306 0.000
A65-A69 Other spirochaetal diseases
0.694 0.306 0.000
A20-A28 Certain zoonotic bacterial diseases
0.694 0.306 0.000
A15-A19 Tuberculosis
0.694 0.306 0.000
H65.3 Chronic mucoid otitis media
0.694 0.306 0.000
N62 Hypertrophy of breast
0.693 0.306 0.000
E16 Other disorders of pancreatic internal secretion
0.693 0.307 0.000
S08 Traumatic amputation of part of head
0.691 0.309 0.000
S07 Crushing injury of head
0.691 0.309 0.000
S05 Injury of eye and orbit
0.691 0.309 0.000
S04 Injury of cranial nerves
0.691 0.309 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.691 0.309 0.000
I08.8 Other multiple valve diseases
0.691 0.309 0.000
V10-V19 Pedal cyclist injured in transport accident
0.691 0.309 0.000
H93.1 Tinnitus
0.691 0.309 0.000
G40.7 Petit mal, unspecified, without grand mal seizures
0.691 0.309 0.000
H69 Other disorders of Eustachian tube
0.690 0.310 0.000
T81.7 Vascular complications following a procedure, not elsewhere classified
0.690 0.310 0.000
I42.0 Dilated cardiomyopathy
0.689 0.311 0.000
M10.90 Gout, unspecified (Multiple sites)
0.689 0.311 0.000
N60.2 Fibroadenosis of breast
0.689 0.311 0.000
G90 Disorders of autonomic nervous system
0.688 0.312 0.000
Y44 Agents primarily affecting blood constituents
0.688 0.312 0.000
S09 Other and unspecified injuries of head
0.685 0.315 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.685 0.315 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.685 0.315 0.000
J60-J70 Lung diseases due to external agents
0.684 0.316 0.000
M07.36 Other psoriatic arthropathies (Lower leg)
0.684 0.316 0.000
H94 Other disorders of ear in diseases classified elsewhere
0.684 0.316 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.684 0.316 0.000
Q80-Q89 Other congenital malformations
0.684 0.316 0.000
D75 Other diseases of blood and blood-forming organs
0.683 0.317 0.000
H93.9 Disorder of ear, unspecified
0.683 0.317 0.000
G43 Migraine
0.683 0.317 0.000
B95.3 Streptococcus pneumoniae as the cause of diseases classified to other chapters
0.683 0.317 0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.683 0.317 0.000
H70 Mastoiditis and related conditions
0.683 0.317 0.000
H68 Eustachian salpingitis and obstruction
0.683 0.317 0.000
H67 Otitis media in diseases classified elsewhere
0.683 0.317 0.000
I28 Other diseases of pulmonary vessels
0.682 0.318 0.000
H60.9 Otitis externa, unspecified
0.681 0.319 0.000
S01.7 Multiple open wounds of head
0.680 0.320 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.679 0.321 0.000
M14 Arthropathies in other diseases classified elsewhere
0.679 0.321 0.000
M12 Other specific arthropathies
0.679 0.321 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.679 0.321 0.000
M08 Juvenile arthritis
0.679 0.321 0.000
H80-H83 Diseases of inner ear
0.678 0.322 0.000
M35.0 Sicca syndrome [Sjogren]
0.678 0.322 0.000
G72 Other myopathies
0.675 0.325 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.675 0.325 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.674 0.326 0.000
M33 Dermatopolymyositis
0.674 0.326 0.000
M32 Systemic lupus erythematosus
0.674 0.326 0.000
M30 Polyarteritis nodosa and related conditions
0.674 0.326 0.000
I05.8 Other mitral valve diseases
0.674 0.326 0.000
I05.1 Rheumatic mitral insufficiency
0.674 0.326 0.000
I42.8 Other cardiomyopathies
0.673 0.326 0.000
S32 Fracture of lumbar spine and pelvis
0.673 0.327 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.673 0.327 0.000
S40.0 Contusion of shoulder and upper arm
0.673 0.327 0.000
Chapter V Mental and behavioural disorders
0.672 0.328 0.000
Q50-Q56 Congenital malformations of genital organs
0.671 0.329 0.000
M50-M54 Other dorsopathies
0.670 0.330 0.000
M25.57 Pain in joint (Ankle and foot)
0.670 0.330 0.000
D86 Sarcoidosis
0.669 0.331 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.669 0.331 0.000
S42 Fracture of shoulder and upper arm
0.669 0.331 0.000
M10.97 Gout, unspecified (Ankle and foot)
0.669 0.331 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.668 0.331 0.000
B25-B34 Other viral diseases
0.668 0.332 0.000
I12.0 Hypertensive renal disease with renal failure
0.668 0.332 0.000
T81.9 Unspecified complication of procedure
0.667 0.333 0.000
T81.6 Acute reaction to foreign substance accidentally left during a procedure
0.667 0.333 0.000
T81.1 Shock during or resulting from a procedure, not elsewhere classified
0.667 0.333 0.000
S01.1 Open wound of eyelid and periocular area
0.666 0.334 0.000
L40 Psoriasis
0.666 0.334 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.665 0.335 0.000
L27 Dermatitis due to substances taken internally
0.665 0.335 0.000
T17 Foreign body in respiratory tract
0.664 0.336 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.664 0.336 0.000
Y57 Other and unspecified drugs and medicaments
0.664 0.336 0.000
E83.1 Disorders of iron metabolism
0.664 0.336 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.663 0.337 0.000
Q35-Q37 Cleft lip and cleft palate
0.663 0.337 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.663 0.337 0.000
M19.9 Arthrosis, unspecified
0.663 0.337 0.000
D53 Other nutritional anaemias
0.662 0.338 0.000
T19 Foreign body in genito-urinary tract
0.662 0.338 0.000
T15 Foreign body on external eye
0.662 0.338 0.000
T16 Foreign body in ear
0.662 0.338 0.000
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
0.661 0.339 0.000
N64 Other disorders of breast
0.661 0.339 0.000
S72 Fracture of femur
0.660 0.340 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.660 0.340 0.000
I27.8 Other specified pulmonary heart diseases
0.660 0.340 0.000
I27.1 Kyphoscoliotic heart disease
0.660 0.340 0.000
I26 Pulmonary embolism
0.660 0.340 0.000
G83 Other paralytic syndromes
0.660 0.340 0.000
M07.30 Other psoriatic arthropathies (Multiple sites)
0.659 0.340 0.000
M67.8 Other specified disorders of synovium and tendon
0.659 0.341 0.000
D80 Immunodeficiency with predominantly antibody defects
0.659 0.341 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.659 0.341 0.000
I46.9 Cardiac arrest, unspecified
0.659 0.341 0.000
M25.9 Joint disorder, unspecified
0.658 0.341 0.000
M25.3 Other instability of joint
0.658 0.341 0.000
M25.2 Flail joint
0.658 0.341 0.000
M25.1 Fistula of joint
0.658 0.341 0.000
I42.7 Cardiomyopathy due to drugs and other external agents
0.658 0.341 0.000
I42.6 Alcoholic cardiomyopathy
0.658 0.341 0.000
I42.5 Other restrictive cardiomyopathy
0.658 0.341 0.000
I42.4 Endocardial fibroelastosis
0.658 0.341 0.000
I42.3 Endomyocardial (eosinophilic) disease
0.658 0.341 0.000
H40-H42 Glaucoma
0.658 0.342 0.000
L02 Cutaneous abscess, furuncle and carbuncle
0.658 0.342 0.000
S48 Traumatic amputation of shoulder and upper arm
0.657 0.342 0.000
S45 Injury of blood vessels at shoulder and upper arm level
0.657 0.342 0.000
S44 Injury of nerves at shoulder and upper arm level
0.657 0.342 0.000
S41 Open wound of shoulder and upper arm
0.657 0.342 0.000
S47 Crushing injury of shoulder and upper arm
0.657 0.342 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.657 0.343 0.000
Y43.9 Primarily systemic agent, unspecified
0.657 0.343 0.000
Y43.8 Other primarily systemic agents, not elsewhere classified
0.657 0.343 0.000
Y43.6 Enzymes, not elsewhere classified
0.657 0.343 0.000
Y43.5 Acidifying and alkalising agents
0.657 0.343 0.000
Y43.2 Antineoplastic natural products
0.657 0.343 0.000
Y43.1 Antineoplastic antimetabolites
0.657 0.343 0.000
Y43.0 Antiallergic and antiemetic drugs
0.657 0.343 0.000
A46 Erysipelas
0.656 0.344 0.000
M25.54 Pain in joint (Hand)
0.656 0.344 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.655 0.345 0.000
I31.3 Pericardial effusion (noninflammatory)
0.655 0.345 0.000
G97.8 Other postprocedural disorders of nervous system
0.654 0.346 0.000
N18 Chronic renal failure
0.654 0.346 0.000
J85 Abscess of lung and mediastinum
0.653 0.347 0.000
J09-J18 Influenza and pneumonia
0.653 0.347 0.000
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure
0.653 0.347 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.652 0.348 0.000
I51 Complications and ill-defined descriptions of heart disease
0.652 0.348 0.000
Q28 Other congenital malformations of circulatory system
0.651 0.349 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.651 0.349 0.000
X60-X84 Intentional self-harm
0.650 0.349 0.000
Chapter XXII Codes for special purposes
0.650 0.350 0.000
J95 Postprocedural respiratory disorders, not elsewhere classified
0.650 0.350 0.000
S06.5 Traumatic subdural haemorrhage
0.649 0.351 0.000
S80 Superficial injury of lower leg
0.649 0.351 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.649 0.351 0.000
H10-H13 Disorders of conjunctiva
0.648 0.351 0.000
L23 Allergic contact dermatitis
0.648 0.352 0.000
M24 Other specific joint derangements
0.648 0.352 0.000
B95.2 Streptococcus, group D, as the cause of diseases classified to other chapters
0.648 0.352 0.000
G82 Paraplegia and tetraplegia
0.647 0.353 0.000
D73 Diseases of spleen
0.647 0.353 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.647 0.353 0.000
I31.9 Disease of pericardium, unspecified
0.647 0.353 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.646 0.354 0.000
J81 Pulmonary oedema
0.646 0.354 0.000
Y45.1 Salicylates
0.646 0.354 0.000
G54.0 Brachial plexus disorders
0.644 0.356 0.000
D51 Vitamin B12 deficiency anaemia
0.643 0.357 0.000
E83.3 Disorders of phosphorus metabolism
0.643 0.357 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.642 0.358 0.000
T98 Sequelae of other and unspecified effects of external causes
0.642 0.358 0.000
T95 Sequelae of burns, corrosions and frostbite
0.642 0.358 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.642 0.358 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.642 0.358 0.000
Q21.1 Atrial septal defect
0.641 0.359 0.000
H92.2 Otorrhagia
0.640 0.360 0.000
I49 Other cardiac arrhythmias
0.640 0.360 0.000
E83.4 Disorders of magnesium metabolism
0.639 0.361 0.000
S62.6 Fracture of other finger
0.639 0.361 0.000
G73 Disorders of myoneural junction and muscle in diseases classified elsewhere
0.638 0.362 0.000
G41 Status epilepticus
0.637 0.363 0.000
T85.2 Mechanical complication of intraocular lens
0.637 0.363 0.000
G50 Disorders of trigeminal nerve
0.637 0.363 0.000
N00-N08 Glomerular diseases
0.637 0.363 0.000
M21.1 Varus deformity, not elsewhere classified
0.637 0.363 0.000
H57 Other disorders of eye and adnexa
0.637 0.363 0.000
M10.4 Other secondary gout
0.635 0.364 0.000
M10.3 Gout due to impairment of renal function
0.635 0.364 0.000
M10.2 Drug-induced gout
0.635 0.364 0.000
M10.1 Lead-induced gout
0.635 0.364 0.000
M10.0 Idiopathic gout
0.635 0.364 0.000
T93.8 Sequelae of other specified injuries of lower limb
0.636 0.364 0.000
G97.0 Cerebrospinal fluid leak from spinal puncture
0.635 0.364 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.635 0.365 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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