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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs295318
log Bayes Factor = 14.2072
Chromosome 3   position 141,363,176  (GRCh37) Explore rs295318 on Ensembl!
Variant rs295318 is part of Cluster X0057

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.999 0.001 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.999 0.001 0.000
I30-I52 Other forms of heart disease
0.997 0.003 0.000
E70-E90 Metabolic disorders
0.996 0.004 0.000
Chapter X Diseases of the respiratory system
0.996 0.004 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.992 0.008 0.000
J90-J94 Other diseases of pleura
0.988 0.012 0.000
Chapter I Certain infectious and parasitic diseases
0.988 0.012 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.985 0.015 0.000
E86 Volume depletion
0.981 0.019 0.000
M05-M14 Inflammatory polyarthropathies
0.981 0.019 0.000
Chapter VI Diseases of the nervous system
0.980 0.020 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.977 0.023 0.000
G81 Hemiplegia
0.975 0.025 0.000
G81.9 Hemiplegia, unspecified
0.973 0.027 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.973 0.027 0.000
M10 Gout
0.966 0.034 0.000
A30-A49 Other bacterial diseases
0.965 0.035 0.000
J93 Pneumothorax
0.965 0.035 0.000
I27 Other pulmonary heart diseases
0.962 0.038 0.000
I20-I25 Ischaemic heart diseases
0.960 0.040 0.000
I50 Heart failure
0.958 0.042 0.000
E20-E35 Disorders of other endocrine glands
0.958 0.042 0.000
M10.9 Gout, unspecified
0.956 0.044 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.956 0.044 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.954 0.046 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.953 0.047 0.000
J95-J99 Other diseases of the respiratory system
0.949 0.051 0.000
Chapter VIII Diseases of the ear and mastoid process
0.947 0.053 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.943 0.057 0.000
I21 Acute myocardial infarction
0.942 0.058 0.000
I27.2 Other secondary pulmonary hypertension
0.941 0.059 0.000
I05-I09 Chronic rheumatic heart diseases
0.940 0.060 0.000
M45-M49 Spondylopathies
0.939 0.061 0.000
Chapter XX External causes of morbidity and mortality
0.937 0.063 0.000
I21.9 Acute myocardial infarction, unspecified
0.937 0.063 0.000
J93.9 Pneumothorax, unspecified
0.932 0.068 0.000
A49 Bacterial infection of unspecified site
0.931 0.069 0.000
I60-I69 Cerebrovascular diseases
0.930 0.070 0.000
M80-M85 Disorders of bone density and structure
0.929 0.071 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.926 0.074 0.000
I42 Cardiomyopathy
0.923 0.077 0.000
E87.6 Hypokalaemia
0.922 0.078 0.000
I71 Aortic aneurysm and dissection
0.921 0.079 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.912 0.088 0.000
M10.99 Gout, unspecified (Site unspecified)
0.909 0.091 0.000
I69 Sequelae of cerebrovascular disease
0.908 0.092 0.000
M40-M43 Deforming dorsopathies
0.907 0.093 0.000
I50.1 Left ventricular failure
0.902 0.098 0.000
M10.97 Gout, unspecified (Ankle and foot)
0.901 0.099 0.000
O60-O75 Complications of labour and delivery
0.884 0.116 0.000
I33 Acute and subacute endocarditis
0.882 0.118 0.000
Q60-Q64 Congenital malformations of the urinary system
0.880 0.120 0.000
L60-L75 Disorders of skin appendages
0.880 0.120 0.000
A49.8 Other bacterial infections of unspecified site
0.880 0.120 0.000
O72 Postpartum haemorrhage
0.878 0.122 0.000
I27.0 Primary pulmonary hypertension
0.874 0.126 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.873 0.127 0.000
J99 Respiratory disorders in diseases classified elsewhere
0.873 0.127 0.000
H65-H75 Diseases of middle ear and mastoid
0.873 0.127 0.000
L20-L30 Dermatitis and eczema
0.872 0.128 0.000
O72.1 Other immediate postpartum haemorrhage
0.870 0.130 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.870 0.130 0.000
I24 Other acute ischaemic heart diseases
0.869 0.131 0.000
I50.9 Heart failure, unspecified
0.868 0.132 0.000
M86-M90 Other osteopathies
0.867 0.133 0.000
O80-O84 Delivery
0.867 0.133 0.000
I45 Other conduction disorders
0.864 0.136 0.000
H90-H95 Other disorders of ear
0.864 0.136 0.000
Chapter XIV Diseases of the genitourinary system
0.863 0.137 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.862 0.138 0.000
L60 Nail disorders
0.861 0.139 0.000
I95 Hypotension
0.859 0.141 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.859 0.141 0.000
N17-N19 Renal failure
0.858 0.142 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.857 0.143 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.856 0.144 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.853 0.147 0.000
B25-B34 Other viral diseases
0.852 0.148 0.000
I08 Multiple valve diseases
0.852 0.148 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.851 0.149 0.000
Y40 Systemic antibiotics
0.843 0.157 0.000
L27 Dermatitis due to substances taken internally
0.842 0.158 0.000
O85-O92 Complications predominantly related to the puerperium
0.842 0.158 0.000
I74 Arterial embolism and thrombosis
0.841 0.159 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.841 0.159 0.000
N19 Unspecified renal failure
0.841 0.159 0.000
A00-A09 Intestinal infectious diseases
0.839 0.161 0.000
L60.0 Ingrowing nail
0.838 0.162 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.836 0.164 0.000
J98 Other respiratory disorders
0.835 0.165 0.000
I47 Paroxysmal tachycardia
0.835 0.165 0.000
N00-N08 Glomerular diseases
0.834 0.166 0.000
M47 Spondylosis
0.832 0.168 0.000
I46 Cardiac arrest
0.832 0.168 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.832 0.168 0.000
M45 Ankylosing spondylitis
0.831 0.169 0.000
J90 Pleural effusion, not elsewhere classified
0.829 0.171 0.000
A49.0 Staphylococcal infection, unspecified
0.829 0.171 0.000
M41 Scoliosis
0.827 0.173 0.000
A41 Other septicaemia
0.827 0.173 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.825 0.175 0.000
M80 Osteoporosis with pathological fracture
0.824 0.176 0.000
E87.7 Fluid overload
0.822 0.178 0.000
I42.2 Other hypertrophic cardiomyopathy
0.821 0.179 0.000
J92 Pleural plaque
0.820 0.180 0.000
Y57 Other and unspecified drugs and medicaments
0.820 0.180 0.000
J98.4 Other disorders of lung
0.819 0.181 0.000
N18 Chronic renal failure
0.818 0.182 0.000
E88 Other metabolic disorders
0.817 0.183 0.000
I34 Nonrheumatic mitral valve disorders
0.815 0.185 0.000
Q50-Q56 Congenital malformations of genital organs
0.814 0.186 0.000
M50-M54 Other dorsopathies
0.811 0.189 0.000
N03 Chronic nephritic syndrome
0.810 0.190 0.000
E50-E64 Other nutritional deficiencies
0.810 0.190 0.000
M13 Other arthritis
0.808 0.192 0.000
M85 Other disorders of bone density and structure
0.808 0.192 0.000
I42.1 Obstructive hypertrophic cardiomyopathy
0.804 0.196 0.000
L27.0 Generalised skin eruption due to drugs and medicaments
0.804 0.196 0.000
E23 Hypofunction and other disorders of pituitary gland
0.803 0.197 0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium
0.801 0.199 0.000
G90-G99 Other disorders of the nervous system
0.800 0.200 0.000
I33.0 Acute and subacute infective endocarditis
0.799 0.201 0.000
E21.0 Primary hyperparathyroidism
0.797 0.203 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.796 0.204 0.000
N03.9 Unspecified
0.793 0.207 0.000
E73 Lactose intolerance
0.792 0.208 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.790 0.210 0.000
L50-L54 Urticaria and erythema
0.790 0.210 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.789 0.210 0.000
I30 Acute pericarditis
0.789 0.211 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.789 0.211 0.000
E27 Other disorders of adrenal gland
0.789 0.211 0.000
I98.2 Oesophageal varices in diseases classified elsewhere
0.787 0.213 0.000
E80.4 Gilbert's syndrome
0.785 0.215 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.782 0.218 0.000
I08.0 Disorders of both mitral and aortic valves
0.782 0.218 0.000
A40 Streptococcal septicaemia
0.780 0.220 0.000
J91 Pleural effusion in conditions classified elsewhere
0.779 0.221 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.778 0.222 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.778 0.222 0.000
Q61 Cystic kidney disease
0.777 0.223 0.000
I07 Rheumatic tricuspid valve diseases
0.774 0.226 0.000
N18.5 Chronic kidney disease, stage 5
0.774 0.226 0.000
J93.1 Other spontaneous pneumothorax
0.773 0.227 0.000
Y52 Agents primarily affecting the cardiovascular system
0.771 0.229 0.000
G82 Paraplegia and tetraplegia
0.771 0.229 0.000
H91 Other hearing loss
0.769 0.231 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.767 0.233 0.000
Q80-Q89 Other congenital malformations
0.766 0.234 0.000
Chapter V Mental and behavioural disorders
0.766 0.234 0.000
J86 Pyothorax
0.766 0.234 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.765 0.235 0.000
B35-B49 Mycoses
0.764 0.236 0.000
I95.9 Hypotension, unspecified
0.763 0.237 0.000
B15-B19 Viral hepatitis
0.763 0.237 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.763 0.237 0.000
I70 Atherosclerosis
0.761 0.239 0.000
M07 Psoriatic and enteropathic arthropathies
0.760 0.240 0.000
M60-M63 Disorders of muscles
0.760 0.240 0.000
I24.9 Acute ischaemic heart disease, unspecified
0.760 0.240 0.000
J93.0 Spontaneous tension pneumothorax
0.758 0.242 0.000
Y43 Primarily systemic agents
0.758 0.242 0.000
I36 Nonrheumatic tricuspid valve disorders
0.757 0.243 0.000
I42.6 Alcoholic cardiomyopathy
0.757 0.243 0.000
M47.8 Other spondylosis
0.756 0.244 0.000
E87.0 Hyperosmolality and hypernatraemia
0.756 0.244 0.000
J99.8 Respiratory disorders in other diseases classified elsewhere
0.754 0.246 0.000
E40-E46 Malnutrition
0.749 0.250 0.000
J92.9 Pleural plaque without asbestos
0.747 0.253 0.000
I69.1 Sequelae of intracerebral haemorrhage
0.747 0.253 0.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.746 0.254 0.000
M47.86 Other spondylosis (Lumbar region)
0.745 0.255 0.000
M10.96 Gout, unspecified (Lower leg)
0.744 0.256 0.000
G12 Spinal muscular atrophy and related syndromes
0.744 0.256 0.000
I95.8 Other hypotension
0.743 0.257 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.742 0.258 0.000
M41.9 Scoliosis, unspecified
0.741 0.259 0.000
O00-O08 Pregnancy with abortive outcome
0.741 0.259 0.000
I45.1 Other and unspecified right bundle-branch block
0.740 0.260 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.739 0.261 0.000
M00-M03 Infectious arthropathies
0.737 0.263 0.000
J84 Other interstitial pulmonary diseases
0.737 0.263 0.000
O82 Single delivery by Caesarean section
0.737 0.263 0.000
I69.3 Sequelae of cerebral infarction
0.735 0.264 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.735 0.265 0.000
D50-D53 Nutritional anaemias
0.735 0.265 0.000
W20-W49 Exposure to inanimate mechanical forces
0.735 0.265 0.000
G70-G73 Diseases of myoneural junction and muscle
0.734 0.266 0.000
J40-J47 Chronic lower respiratory diseases
0.733 0.267 0.000
I24.8 Other forms of acute ischaemic heart disease
0.733 0.267 0.000
Q60 Renal agenesis and other reduction defects of kidney
0.733 0.267 0.000
I05 Rheumatic mitral valve diseases
0.732 0.268 0.000
H66 Suppurative and unspecified otitis media
0.731 0.269 0.000
I37 Pulmonary valve disorders
0.730 0.270 0.000
N10-N16 Renal tubulo-interstitial diseases
0.730 0.270 0.000
I31 Other diseases of pericardium
0.729 0.271 0.000
H72 Perforation of tympanic membrane
0.729 0.271 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.728 0.272 0.000
G91 Hydrocephalus
0.727 0.273 0.000
N25-N29 Other disorders of kidney and ureter
0.727 0.273 0.000
J99.0 Rheumatoid lung disease
0.726 0.273 0.000
M81 Osteoporosis without pathological fracture
0.726 0.274 0.000
A04 Other bacterial intestinal infections
0.726 0.274 0.000
E24 Cushing's syndrome
0.726 0.274 0.000
Y00-Y09 Assault
0.724 0.276 0.000
Y40.0 Penicillins
0.723 0.277 0.000
M80.9 Unspecified osteoporosis with pathological fracture
0.721 0.279 0.000
B99-B99 Other infectious diseases
0.721 0.279 0.000
I46.0 Cardiac arrest with successful resuscitation
0.721 0.279 0.000
H74 Other disorders of middle ear and mastoid
0.721 0.279 0.000
A41.9 Septicaemia, unspecified
0.720 0.280 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I71.0 Dissection of aorta [any part]
0.717 0.283 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.716 0.283 0.000
E20 Hypoparathyroidism
0.716 0.284 0.000
I62 Other nontraumatic intracranial haemorrhage
0.715 0.285 0.000
I52 Other heart disorders in diseases classified elsewhere
0.715 0.285 0.000
I48 Atrial fibrillation and flutter
0.715 0.285 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.715 0.285 0.000
I41 Myocarditis in diseases classified elsewhere
0.715 0.285 0.000
I40 Acute myocarditis
0.715 0.285 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.715 0.285 0.000
I32 Pericarditis in diseases classified elsewhere
0.715 0.285 0.000
E85 Amyloidosis
0.714 0.285 0.000
E84 Cystic fibrosis
0.714 0.285 0.000
E79 Disorders of purine and pyrimidine metabolism
0.714 0.285 0.000
E77 Disorders of glycoprotein metabolism
0.714 0.285 0.000
E76 Disorders of glycosaminoglycan metabolism
0.714 0.285 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.714 0.285 0.000
E74 Other disorders of carbohydrate metabolism
0.714 0.285 0.000
E72 Other disorders of amino-acid metabolism
0.714 0.285 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.714 0.285 0.000
E70 Disorders of aromatic amino-acid metabolism
0.714 0.285 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.714 0.285 0.000
M88 Paget's disease of bone [osteitis deformans]
0.713 0.287 0.000
B25 Cytomegaloviral disease
0.713 0.287 0.000
O61 Failed induction of labour
0.712 0.287 0.000
J44 Other chronic obstructive pulmonary disease
0.711 0.289 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.711 0.289 0.000
I60 Subarachnoid haemorrhage
0.710 0.290 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.710 0.290 0.000
J94 Other pleural conditions
0.709 0.291 0.000
M89 Other disorders of bone
0.709 0.291 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.708 0.292 0.000
B50-B64 Protozoal diseases
0.708 0.292 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.708 0.292 0.000
A75-A79 Rickettsioses
0.708 0.292 0.000
A70-A74 Other diseases caused by chlamydiae
0.708 0.292 0.000
A65-A69 Other spirochaetal diseases
0.708 0.292 0.000
A20-A28 Certain zoonotic bacterial diseases
0.708 0.292 0.000
A15-A19 Tuberculosis
0.708 0.292 0.000
J93.8 Other pneumothorax
0.708 0.292 0.000
J80 Adult respiratory distress syndrome
0.708 0.292 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.707 0.293 0.000
O72.0 Third-stage haemorrhage
0.707 0.293 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.706 0.293 0.000
Q35-Q37 Cleft lip and cleft palate
0.706 0.293 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.706 0.293 0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments
0.706 0.294 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.706 0.294 0.000
O80 Single spontaneous delivery
0.706 0.294 0.000
L27.1 Localised skin eruption due to drugs and medicaments
0.706 0.294 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.706 0.294 0.000
G80 Infantile cerebral palsy
0.705 0.294 0.000
Q10 Congenital malformations of eyelid, lachrymal apparatus and orbit
0.705 0.295 0.000
F30-F39 Mood [affective] disorders
0.705 0.295 0.000
Y40.9 Systemic antibiotic, unspecified
0.705 0.295 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.705 0.295 0.000
E28 Ovarian dysfunction
0.704 0.296 0.000
M14 Arthropathies in other diseases classified elsewhere
0.703 0.297 0.000
M12 Other specific arthropathies
0.703 0.297 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.703 0.297 0.000
M08 Juvenile arthritis
0.703 0.297 0.000
W50-W64 Exposure to animate mechanical forces
0.702 0.298 0.000
E29 Testicular dysfunction
0.702 0.298 0.000
M91-M94 Chondropathies
0.701 0.299 0.000
M54 Dorsalgia
0.700 0.300 0.000
I42.8 Other cardiomyopathies
0.700 0.300 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.699 0.301 0.000
Q18 Other congenital malformations of face and neck
0.699 0.301 0.000
G81.1 Spastic hemiplegia
0.699 0.301 0.000
G81.0 Flaccid hemiplegia
0.699 0.301 0.000
B65-B83 Helminthiases
0.698 0.302 0.000
H90 Conductive and sensorineural hearing loss
0.698 0.302 0.000
M46 Other inflammatory spondylopathies
0.698 0.302 0.000
I28 Other diseases of pulmonary vessels
0.697 0.303 0.000
I45.9 Conduction disorder, unspecified
0.697 0.303 0.000
M43 Other deforming dorsopathies
0.696 0.304 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.696 0.304 0.000
H93 Other disorders of ear, not elsewhere classified
0.694 0.306 0.000
N18.4 Chronic kidney disease, stage 4
0.694 0.306 0.000
M05 Seropositive rheumatoid arthritis
0.694 0.306 0.000
M47.9 Spondylosis, unspecified
0.694 0.306 0.000
H60-H62 Diseases of external ear
0.694 0.306 0.000
A09 Diarrhoea and gastro-enteritis of presumed infectious origin
0.693 0.307 0.000
M10.4 Other secondary gout
0.693 0.307 0.000
M10.3 Gout due to impairment of renal function
0.693 0.307 0.000
M10.2 Drug-induced gout
0.693 0.307 0.000
M10.1 Lead-induced gout
0.693 0.307 0.000
M10.0 Idiopathic gout
0.693 0.307 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.692 0.308 0.000
A48 Other bacterial diseases, not elsewhere classified
0.692 0.308 0.000
A44 Bartonellosis
0.692 0.308 0.000
A43 Nocardiosis
0.692 0.308 0.000
A42 Actinomycosis
0.692 0.308 0.000
A39 Meningococcal infection
0.692 0.308 0.000
A37 Whooping cough
0.692 0.308 0.000
A36 Diphtheria
0.692 0.308 0.000
A32 Listeriosis
0.692 0.308 0.000
A31 Infection due to other mycobacteria
0.692 0.308 0.000
A30 Leprosy [Hansen's disease]
0.692 0.308 0.000
A38 Scarlet fever
0.692 0.308 0.000
A35 Other tetanus
0.692 0.308 0.000
A34 Obstetrical tetanus
0.692 0.308 0.000
A33 Tetanus neonatorum
0.692 0.308 0.000
I47.2 Ventricular tachycardia
0.692 0.308 0.000
N99-N99 Other disorders of the genitourinary system
0.691 0.309 0.000
I27.8 Other specified pulmonary heart diseases
0.689 0.310 0.000
I27.1 Kyphoscoliotic heart disease
0.689 0.310 0.000
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.689 0.311 0.000
I23 Certain current complications following acute myocardial infarction
0.688 0.312 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.687 0.313 0.000
E34 Other endocrine disorders
0.687 0.313 0.000
E32 Diseases of thymus
0.687 0.313 0.000
E31 Polyglandular dysfunction
0.687 0.313 0.000
E30 Disorders of puberty, not elsewhere classified
0.687 0.313 0.000
E26 Hyperaldosteronism
0.687 0.313 0.000
E25 Adrenogenital disorders
0.687 0.313 0.000
I49 Other cardiac arrhythmias
0.687 0.313 0.000
I95.2 Hypotension due to drugs
0.686 0.314 0.000
M10.98 Gout, unspecified (Other)
0.685 0.315 0.000
M10.95 Gout, unspecified (Pelvic region and thigh)
0.685 0.315 0.000
M10.94 Gout, unspecified (Hand)
0.685 0.315 0.000
M10.93 Gout, unspecified (Forearm)
0.685 0.315 0.000
M10.92 Gout, unspecified (Upper arm)
0.685 0.315 0.000
M10.91 Gout, unspecified (Shoulder region)
0.685 0.315 0.000
M10.90 Gout, unspecified (Multiple sites)
0.685 0.315 0.000
E87.4 Mixed disorder of acid-base balance
0.685 0.315 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.685 0.315 0.000
I45.3 Trifascicular block
0.685 0.315 0.000
E87.3 Alkalosis
0.684 0.316 0.000
B34 Viral infection of unspecified site
0.684 0.316 0.000
M50 Cervical disk disorders
0.684 0.316 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.682 0.318 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.682 0.318 0.000
Y57.9 Drug or medicament, unspecified
0.681 0.319 0.000
J96 Respiratory failure, not elsewhere classified
0.680 0.319 0.000
J99.1 Respiratory disorders in other diffuse connective tissue disorders
0.680 0.320 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.680 0.320 0.000
D60-D64 Aplastic and other anaemias
0.680 0.320 0.000
W00-W19 Falls
0.679 0.321 0.000
J60-J70 Lung diseases due to external agents
0.678 0.322 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.678 0.322 0.000
O72.2 Delayed and secondary postpartum haemorrhage
0.677 0.323 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.677 0.323 0.000
L10-L14 Bullous disorders
0.676 0.324 0.000
Q00-Q07 Congenital malformations of the nervous system
0.676 0.324 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.675 0.325 0.000
M11 Other crystal arthropathies
0.675 0.325 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.674 0.326 0.000
I09 Other rheumatic heart diseases
0.674 0.326 0.000
I06 Rheumatic aortic valve diseases
0.674 0.326 0.000
Chapter XXII Codes for special purposes
0.674 0.326 0.000
A04.8 Other specified bacterial intestinal infections
0.674 0.326 0.000
G91.9 Hydrocephalus, unspecified
0.673 0.327 0.000
M49 Spondylopathies in diseases classified elsewhere
0.673 0.327 0.000
I51 Complications and ill-defined descriptions of heart disease
0.673 0.327 0.000
J86.9 Pyothorax without fistula
0.673 0.327 0.000
L60.8 Other nail disorders
0.673 0.327 0.000
Y35-Y36 Legal intervention and operations of war
0.672 0.328 0.000
Y10-Y34 Event of undetermined intent
0.672 0.328 0.000
X85-X99 Assault
0.672 0.328 0.000
X50-X57 Overexertion, travel and privation
0.672 0.328 0.000
X30-X39 Exposure to forces of nature
0.672 0.328 0.000
X20-X29 Contact with venomous animals and plants
0.672 0.328 0.000
X10-X19 Contact with heat and hot substances
0.672 0.328 0.000
X00-X09 Exposure to smoke, fire and flames
0.672 0.328 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.672 0.328 0.000
W75-W84 Other accidental threats to breathing
0.672 0.328 0.000
W65-W74 Accidental drowning and submersion
0.672 0.328 0.000
V98-V99 Other and unspecified transport accidents
0.672 0.328 0.000
V95-V97 Air and space transport accidents
0.672 0.328 0.000
V90-V94 Water transport accidents
0.672 0.328 0.000
V70-V79 Bus occupant injured in transport accident
0.672 0.328 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.672 0.328 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.672 0.328 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.672 0.328 0.000
V20-V29 Motorcycle rider injured in transport accident
0.672 0.328 0.000
V01-V09 Pedestrian injured in transport accident
0.672 0.328 0.000
M41.99 Scoliosis, unspecified (Site unspecified)
0.672 0.328 0.000
M85.8 Other specified disorders of bone density and structure
0.672 0.328 0.000
M41.8 Other forms of scoliosis
0.671 0.329 0.000
J00-J06 Acute upper respiratory infections
0.671 0.329 0.000
M86 Osteomyelitis
0.670 0.330 0.000
Y44 Agents primarily affecting blood constituents
0.670 0.330 0.000
L60.9 Nail disorder, unspecified
0.670 0.330 0.000
O99.5 Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium
0.669 0.331 0.000
L53 Other erythematous conditions
0.669 0.331 0.000
M65-M68 Disorders of synovium and tendon
0.669 0.331 0.000
J95 Postprocedural respiratory disorders, not elsewhere classified
0.668 0.332 0.000
I08.8 Other multiple valve diseases
0.668 0.332 0.000
A49.3 Mycoplasma infection, unspecified
0.668 0.332 0.000
A49.2 Haemophilus influenzae infection, unspecified
0.668 0.332 0.000
I42.9 Cardiomyopathy, unspecified
0.667 0.333 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.667 0.333 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.667 0.333 0.000
G12.2 Motor neuron disease
0.667 0.333 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.666 0.334 0.000
Y57.6 Other diagnostic agents
0.666 0.334 0.000
M83 Adult osteomalacia
0.666 0.334 0.000
M82 Osteoporosis in diseases classified elsewhere
0.666 0.334 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.666 0.334 0.000
E53 Deficiency of other B group vitamins
0.665 0.335 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.665 0.335 0.000
I47.9 Paroxysmal tachycardia, unspecified
0.664 0.336 0.000
Y59 Other and unspecified vaccines and biological substances
0.664 0.336 0.000
Y58 Bacterial vaccines
0.664 0.336 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.664 0.336 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.664 0.336 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.664 0.336 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.664 0.336 0.000
Y48 Anaesthetics and therapeutic gases
0.664 0.336 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.664 0.336 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.664 0.336 0.000
H65 Nonsuppurative otitis media
0.664 0.336 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.663 0.337 0.000
O90 Complications of the puerperium, not elsewhere classified
0.663 0.337 0.000
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.663 0.337 0.000
I47.0 Reentry ventricular arrhythmia
0.663 0.337 0.000
M13.9 Arthritis, unspecified
0.662 0.338 0.000
I42.7 Cardiomyopathy due to drugs and other external agents
0.662 0.338 0.000
I42.5 Other restrictive cardiomyopathy
0.662 0.338 0.000
I42.4 Endocardial fibroelastosis
0.662 0.338 0.000
I42.3 Endomyocardial (eosinophilic) disease
0.662 0.338 0.000
Q61.2 Polycystic kidney, adult type
0.662 0.338 0.000
I25 Chronic ischaemic heart disease
0.662 0.338 0.000
V40-V49 Car occupant injured in transport accident
0.661 0.338 0.000
O86 Other puerperal infections
0.661 0.339 0.000
I99 Other and unspecified disorders of circulatory system
0.661 0.339 0.000
N18.2 Chronic kidney disease, stage 2
0.661 0.339 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.660 0.339 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.660 0.339 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.660 0.339 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.660 0.339 0.000
J09-J18 Influenza and pneumonia
0.659 0.341 0.000
E21.3 Hyperparathyroidism, unspecified
0.658 0.342 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.658 0.342 0.000
L28 Lichen simplex chronicus and prurigo
0.658 0.342 0.000
M80.1 Postoophorectomy osteoporosis with pathological fracture
0.658 0.342 0.000
A49.9 Bacterial infection, unspecified
0.657 0.343 0.000
H91.9 Hearing loss, unspecified
0.656 0.344 0.000
M47.96 Spondylosis, unspecified (Lumbar region)
0.656 0.344 0.000
I07.1 Tricuspid insufficiency
0.655 0.345 0.000
E23.0 Hypopituitarism
0.655 0.345 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.654 0.345 0.000
O98 Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.654 0.346 0.000
O97 Death from sequelae of direct obstetric causes
0.654 0.346 0.000
O96 Death from any obstetric cause occurring more than 42 days but less than one year after delivery
0.654 0.346 0.000
O95 Obstetric death of unspecified cause
0.654 0.346 0.000
O94 Sequelae of complication of pregnancy, childbirth and the puerperium
0.654 0.346 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.654 0.346 0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria
0.654 0.346 0.000
O87 Venous complications in the puerperium
0.654 0.346 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.653 0.347 0.000
H66.3 Other chronic suppurative otitis media
0.653 0.347 0.000
L73 Other follicular disorders
0.652 0.348 0.000
E27.9 Disorder of adrenal gland, unspecified
0.652 0.348 0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.651 0.349 0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage
0.651 0.349 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.651 0.349 0.000
M42 Spinal osteochondrosis
0.650 0.350 0.000
M40 Kyphosis and lordosis
0.650 0.350 0.000
D51 Vitamin B12 deficiency anaemia
0.649 0.351 0.000
X60-X84 Intentional self-harm
0.649 0.351 0.000
M48 Other spondylopathies
0.647 0.352 0.000
G83 Other paralytic syndromes
0.646 0.354 0.000
E73.9 Lactose intolerance, unspecified
0.646 0.354 0.000
O99.8 Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
0.646 0.354 0.000
G11 Hereditary ataxia
0.645 0.354 0.000
Q23 Congenital malformations of aortic and mitral valves
0.645 0.355 0.000
I34.0 Mitral (valve) insufficiency
0.645 0.355 0.000
M50.1 Cervical disk disorder with radiculopathy
0.645 0.355 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.644 0.356 0.000
O99.3 Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
0.643 0.357 0.000
V80-V89 Other land transport accidents
0.643 0.357 0.000
E87.2 Acidosis
0.642 0.358 0.000
I27.9 Pulmonary heart disease, unspecified
0.641 0.358 0.000
I30.9 Acute pericarditis, unspecified
0.640 0.360 0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified
0.639 0.361 0.000
H91.1 Presbycusis
0.638 0.362 0.000
Y40.1 Cefalosporins and other -lactam antibiotics
0.638 0.362 0.000
I34.1 Mitral (valve) prolapse
0.638 0.362 0.000
H71 Cholesteatoma of middle ear
0.638 0.362 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.637 0.363 0.000
M85.0 Fibrous dysplasia (monostotic)
0.637 0.363 0.000
A80-A89 Viral infections of the central nervous system
0.636 0.363 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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