TreeWAS – Variant ID: rs2954029

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E78.0 Pure hypercholesterolaemia	0.000	0.000	1.000
I25.1 Atherosclerotic heart disease	0.000	0.000	1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.000	0.000	1.000
E78.5 Hyperlipidaemia, unspecified	0.000	0.002	0.998
I25 Chronic ischaemic heart disease	0.000	0.006	0.994
E78.2 Mixed hyperlipidaemia	0.000	0.037	0.963
I25.8 Other forms of chronic ischaemic heart disease	0.000	0.038	0.962
I25.3 Aneurysm of heart	0.000	0.079	0.921
I25.9 Chronic ischaemic heart disease, unspecified	0.000	0.128	0.872
E78.1 Pure hyperglyceridaemia	0.000	0.146	0.854
K76.0 Fatty (change of) liver, not elsewhere classified	0.000	0.153	0.847
I25.0 Atherosclerotic cardiovascular disease, so described	0.000	0.156	0.844
E78.4 Other hyperlipidaemia	0.000	0.166	0.834
I25.4 Coronary artery aneurysm	0.000	0.204	0.796
E78.6 Lipoprotein deficiency	0.000	0.272	0.728
E78.8 Other disorders of lipoprotein metabolism	0.000	0.281	0.719
I25.5 Ischaemic cardiomyopathy	0.000	0.307	0.693
I25.6 Silent myocardial ischaemia	0.000	0.319	0.681
E78.9 Disorder of lipoprotein metabolism, unspecified	0.000	0.353	0.647
E78.3 Hyperchylomicronaemia	0.000	0.403	0.596
I25.2 Old myocardial infarction	0.000	0.417	0.583
I21.1 Acute transmural myocardial infarction of inferior wall	0.000	0.443	0.557
I20-I25 Ischaemic heart diseases	0.000	0.467	0.533
I21 Acute myocardial infarction	0.000	0.468	0.532
I21.0 Acute transmural myocardial infarction of anterior wall	0.000	0.564	0.436
I21.4 Acute subendocardial myocardial infarction	0.000	0.582	0.418
I21.X Presumed acute myicardial infaction (unconfirmed)	0.000	0.619	0.381
I23 Certain current complications following acute myocardial infarction	0.000	0.640	0.360
I50.1 Left ventricular failure	0.000	0.662	0.338
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.000	0.742	0.258
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.000	0.742	0.258
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.000	0.742	0.258
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.000	0.742	0.258
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.000	0.742	0.258
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.000	0.742	0.258
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.000	0.742	0.258
I50 Heart failure	0.000	0.758	0.242
I23.8 Other current complications following acute myocardial infarction	0.000	0.764	0.236
K76 Other diseases of liver	0.000	0.764	0.236
I50.0 Congestive heart failure	0.000	0.765	0.235
I21.2 Acute transmural myocardial infarction of other sites	0.000	0.767	0.233
I21.3 Acute transmural myocardial infarction of unspecified site	0.001	0.776	0.224
K76.7 Hepatorenal syndrome	0.000	0.797	0.203
K76.6 Portal hypertension	0.000	0.806	0.194
K76.5 Hepatic veno-occlusive disease	0.000	0.831	0.169
K76.4 Peliosis hepatis	0.000	0.831	0.169
K76.3 Infarction of liver	0.000	0.831	0.169
K76.2 Central haemorrhagic necrosis of liver	0.000	0.831	0.169
K76.1 Chronic passive congestion of liver	0.000	0.850	0.149
I22 Subsequent myocardial infarction	0.000	0.851	0.148
I24 Other acute ischaemic heart diseases	0.000	0.864	0.136
K76.9 Liver disease, unspecified	0.000	0.887	0.113
I22.0 Subsequent myocardial infarction of anterior wall	0.000	0.894	0.106
I21.9 Acute myocardial infarction, unspecified	0.000	0.900	0.100
I24.1 Dressler's syndrome	0.000	0.906	0.094
I22.9 Subsequent myocardial infarction of unspecified site	0.000	0.919	0.081
I20 Angina pectoris	0.000	0.922	0.078
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.000	0.926	0.073
I22.1 Subsequent myocardial infarction of inferior wall	0.000	0.927	0.073
I24.9 Acute ischaemic heart disease, unspecified	0.000	0.929	0.070
K76.8 Other specified diseases of liver	0.000	0.938	0.062
I35.2 Aortic (valve) stenosis with insufficiency	0.000	0.939	0.061
I35 Nonrheumatic aortic valve disorders	0.000	0.944	0.056
I22.8 Subsequent myocardial infarction of other sites	0.000	0.945	0.054
I35.0 Aortic (valve) stenosis	0.000	0.947	0.053
I50.9 Heart failure, unspecified	0.000	0.949	0.051
I35.9 Aortic valve disorder, unspecified	0.000	0.950	0.050
I20.9 Angina pectoris, unspecified	0.000	0.953	0.047
I20.8 Other forms of angina pectoris	0.000	0.959	0.041
I24.8 Other forms of acute ischaemic heart disease	0.000	0.960	0.040
I30-I52 Other forms of heart disease	0.000	0.964	0.036
I35.1 Aortic (valve) insufficiency	0.000	0.968	0.032
I31 Other diseases of pericardium	0.000	0.969	0.031
I35.8 Other aortic valve disorders	0.000	0.970	0.030
I31.9 Disease of pericardium, unspecified	0.000	0.970	0.030
I42.6 Alcoholic cardiomyopathy	0.000	0.971	0.029
I42 Cardiomyopathy	0.000	0.971	0.029
I33 Acute and subacute endocarditis	0.000	0.971	0.029
I37 Pulmonary valve disorders	0.000	0.972	0.028
I20.1 Angina pectoris with documented spasm	0.000	0.972	0.028
Chapter IX Diseases of the circulatory system	0.000	0.973	0.027
I52 Other heart disorders in diseases classified elsewhere	0.000	0.974	0.026
I48 Atrial fibrillation and flutter	0.000	0.974	0.026
I41 Myocarditis in diseases classified elsewhere	0.000	0.974	0.026
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.000	0.974	0.026
I32 Pericarditis in diseases classified elsewhere	0.000	0.974	0.026
I40 Acute myocarditis	0.000	0.975	0.025
I33.0 Acute and subacute infective endocarditis	0.000	0.976	0.024
I42.9 Cardiomyopathy, unspecified	0.000	0.976	0.024
I37.1 Pulmonary valve insufficiency	0.000	0.977	0.023
I47 Paroxysmal tachycardia	0.000	0.977	0.023
I43 Cardiomyopathy in diseases classified elsewhere	0.000	0.977	0.023
I31.8 Other specified diseases of pericardium	0.000	0.978	0.022
I31.2 Haemopericardium, not elsewhere classified	0.000	0.978	0.022
I31.0 Chronic adhesive pericarditis	0.000	0.978	0.022
I42.7 Cardiomyopathy due to drugs and other external agents	0.000	0.979	0.021
I42.0 Dilated cardiomyopathy	0.000	0.979	0.021
I31.1 Chronic constrictive pericarditis	0.000	0.979	0.021
I42.4 Endocardial fibroelastosis	0.000	0.979	0.021
I42.5 Other restrictive cardiomyopathy	0.000	0.979	0.021
I42.3 Endomyocardial (eosinophilic) disease	0.000	0.979	0.021
I30 Acute pericarditis	0.000	0.979	0.021
I00-I02 Acute rheumatic fever	0.000	0.979	0.021
I37.9 Pulmonary valve disorder, unspecified	0.000	0.979	0.020
I37.8 Other pulmonary valve disorders	0.000	0.979	0.020
I37.2 Pulmonary valve stenosis with insufficiency	0.000	0.979	0.020
I36 Nonrheumatic tricuspid valve disorders	0.000	0.980	0.020
I37.0 Pulmonary valve stenosis	0.000	0.981	0.019
I33.9 Acute endocarditis, unspecified	0.000	0.981	0.019
I32.8 Pericarditis in other diseases classified elsewhere	0.000	0.981	0.019
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere	0.000	0.981	0.019
I32.0 Pericarditis in bacterial diseases classified elsewhere	0.000	0.981	0.019
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere	0.000	0.981	0.019
I39.4 Multiple valve disorders in diseases classified elsewhere	0.000	0.981	0.019
I39.3 Pulmonary valve disorders in diseases classified elsewhere	0.000	0.981	0.019
I39.2 Tricuspid valve disorders in diseases classified elsewhere	0.000	0.981	0.019
I39.1 Aortic valve disorders in diseases classified elsewhere	0.000	0.981	0.019
I39.0 Mitral valve disorders in diseases classified elsewhere	0.000	0.981	0.019
I41.8 Myocarditis in other diseases classified elsewhere	0.000	0.981	0.019
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere	0.000	0.981	0.019
I41.1 Myocarditis in viral diseases classified elsewhere	0.000	0.981	0.019
I41.0 Myocarditis in bacterial diseases classified elsewhere	0.000	0.981	0.019
I48.9 Atrial fibrillation and atrial flutter, unspecified	0.000	0.981	0.019
I48.4 Atypical atrial flutter	0.000	0.981	0.019
I48.3 Typical atrial flutter	0.000	0.981	0.019
I48.2 Chronic atrial fibrillation	0.000	0.981	0.019
I48.1 Persistent atrial fibrillation	0.000	0.981	0.019
I48.0 Paroxysmal atrial fibrillation	0.000	0.981	0.019
I52.8 Other heart disorders in other diseases classified elsewhere	0.000	0.981	0.019
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere	0.000	0.981	0.019
I52.0 Other heart disorders in bacterial diseases classified elsewhere	0.000	0.981	0.019
I47.1 Supraventricular tachycardia	0.000	0.981	0.019
I40.8 Other acute myocarditis	0.000	0.982	0.018
I40.1 Isolated myocarditis	0.000	0.982	0.018
I42.8 Other cardiomyopathies	0.000	0.982	0.018
I40.9 Acute myocarditis, unspecified	0.000	0.982	0.018
I40.0 Infective myocarditis	0.000	0.982	0.017
I20.0 Unstable angina	0.000	0.983	0.017
I47.2 Ventricular tachycardia	0.000	0.983	0.017
I43.8 Cardiomyopathy in other diseases classified elsewhere	0.000	0.983	0.016
I43.2 Cardiomyopathy in nutritional diseases	0.000	0.983	0.016
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.017	0.983	0.000
I00 Rheumatic fever without mention of heart involvement	0.000	0.984	0.016
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere	0.000	0.985	0.015
I30.8 Other forms of acute pericarditis	0.000	0.985	0.015
I30.0 Acute nonspecific idiopathic pericarditis	0.000	0.985	0.015
I02 Rheumatic chorea	0.000	0.985	0.015
I01 Rheumatic fever with heart involvement	0.000	0.985	0.015
I47.9 Paroxysmal tachycardia, unspecified	0.000	0.985	0.015
I43.1 Cardiomyopathy in metabolic diseases	0.000	0.985	0.015
I36.9 Nonrheumatic tricuspid valve disorder, unspecified	0.000	0.985	0.014
I36.8 Other nonrheumatic tricuspid valve disorders	0.000	0.985	0.014
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency	0.000	0.985	0.014
I36.0 Nonrheumatic tricuspid (valve) stenosis	0.000	0.985	0.014
I95-I99 Other and unspecified disorders of the circulatory system	0.000	0.986	0.014
I98.2 Oesophageal varices in diseases classified elsewhere	0.000	0.986	0.014
I98 Other disorders of circulatory system in diseases classified elsewhere	0.000	0.986	0.014
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)	0.000	0.986	0.014
I30.9 Acute pericarditis, unspecified	0.000	0.986	0.014
I31.3 Pericardial effusion (noninflammatory)	0.000	0.987	0.013
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.013	0.987	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.013	0.987	0.000
B34.9 Viral infection, unspecified	0.000	0.987	0.013
I34 Nonrheumatic mitral valve disorders	0.000	0.987	0.013
I78.1 Naevus, nonneoplastic	0.000	0.987	0.013
T39.0 Salicylates	0.012	0.988	0.000
I30.1 Infective pericarditis	0.000	0.988	0.012
I38 Endocarditis, valve unspecified	0.000	0.988	0.012
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.012	0.988	0.000
I46 Cardiac arrest	0.000	0.988	0.012
T36-T50 Poisoning by drugs, medicaments and biological substances	0.011	0.989	0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.011	0.989	0.000
E10.3 With ophthalmic complications	0.011	0.989	0.000
I01.9 Acute rheumatic heart disease, unspecified	0.000	0.989	0.011
I01.8 Other acute rheumatic heart disease	0.000	0.989	0.011
I01.2 Acute rheumatic myocarditis	0.000	0.989	0.011
I01.1 Acute rheumatic endocarditis	0.000	0.989	0.011
I01.0 Acute rheumatic pericarditis	0.000	0.989	0.011
I02.9 Rheumatic chorea without heart involvement	0.000	0.989	0.011
I02.0 Rheumatic chorea with heart involvement	0.000	0.989	0.011
I34.2 Nonrheumatic mitral (valve) stenosis	0.000	0.989	0.011
I78 Diseases of capillaries	0.000	0.989	0.011
K70-K77 Diseases of liver	0.000	0.989	0.011
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere	0.000	0.989	0.010
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere	0.000	0.990	0.010
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere	0.000	0.990	0.010
I98.0 Cardiovascular syphilis	0.000	0.990	0.010
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.010	0.990	0.000
I47.0 Reentry ventricular arrhythmia	0.000	0.990	0.010
B34 Viral infection of unspecified site	0.000	0.990	0.010
T50.9 Other and unspecified drugs, medicaments and biological substances	0.010	0.990	0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.010	0.990	0.000
I42.2 Other hypertrophic cardiomyopathy	0.000	0.990	0.010
T39.4 Antirheumatics, not elsewhere classified	0.010	0.990	0.000
T39.2 Pyrazolone derivatives	0.010	0.990	0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.010	0.990	0.000
T37.8 Other specified systemic anti-infectives and antiparasitics	0.010	0.990	0.000
I78.0 Hereditary haemorrhagic telangiectasia	0.000	0.990	0.009
T50.8 Diagnostic agents	0.009	0.990	0.000
H26.4 After-cataract	0.000	0.991	0.009
B34.4 Papovirus infection, unspecified	0.000	0.991	0.009
T43.0 Tricyclic and tetracyclic antidepressants	0.009	0.991	0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.009	0.991	0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.009	0.991	0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.009	0.991	0.000
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.009	0.991	0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.009	0.991	0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.009	0.991	0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.009	0.991	0.000
T44.1 Other parasympathomimetics [cholinergics]	0.009	0.991	0.000
T44.0 Anticholinesterase agents	0.009	0.991	0.000
I10-I15 Hypertensive diseases	0.000	0.991	0.009
I34.8 Other nonrheumatic mitral valve disorders	0.000	0.991	0.009
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.009	0.991	0.000
T50.1 Loop [high-ceiling] diuretics	0.009	0.991	0.000
I46.1 Sudden cardiac death, so described	0.000	0.991	0.009
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.009	0.991	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.000	0.991	0.009
B34.8 Other viral infections of unspecified site	0.000	0.991	0.009
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.008	0.991	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.008	0.992	0.000
I36.1 Nonrheumatic tricuspid (valve) insufficiency	0.000	0.992	0.008
T50.7 Analeptics and opioid receptor antagonists	0.008	0.992	0.000
T50.5 Appetite depressants	0.008	0.992	0.000
T50.3 Electrolytic, caloric and water-balance agents	0.008	0.992	0.000
T50.0 Mineralocorticoids and their antagonists	0.008	0.992	0.000
T43.2 Other and unspecified antidepressants	0.008	0.992	0.000
T43.3 Phenothiazine antipsychotics and neuroleptics	0.008	0.992	0.000
T50.4 Drugs affecting uric acid metabolism	0.008	0.992	0.000
K73 Chronic hepatitis, not elsewhere classified	0.000	0.992	0.008
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.008	0.992	0.000
I99 Other and unspecified disorders of circulatory system	0.000	0.992	0.008
K71 Toxic liver disease	0.000	0.992	0.008
I78.9 Disease of capillaries, unspecified	0.000	0.992	0.008
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.008	0.992	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.008	0.992	0.000
T50.6 Antidotes and chelating agents, not elsewhere classified	0.008	0.992	0.000
K77 Liver disorders in diseases classified elsewhere	0.000	0.992	0.008
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.008	0.992	0.000
T37.5 Antiviral drugs	0.008	0.992	0.000
T37.4 Anthelminthics	0.008	0.992	0.000
T37.3 Other antiprotozoal drugs	0.008	0.992	0.000
T37.2 Antimalarials and drugs acting on other blood protozoa	0.008	0.992	0.000
T37.1 Antimycobacterial drugs	0.008	0.992	0.000
T37.0 Sulphonamides	0.008	0.992	0.000
H26.2 Complicated cataract	0.000	0.992	0.008
B34.3 Parvovirus infection, unspecified	0.000	0.992	0.007
B34.2 Coronavirus infection, unspecified	0.000	0.992	0.007
B34.0 Adenovirus infection, unspecified	0.000	0.992	0.007
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.008	0.992	0.000
C44.5 Skin of trunk	0.008	0.992	0.000
T43.8 Other psychotropic drugs, not elsewhere classified	0.007	0.993	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.007	0.993	0.000
I42.1 Obstructive hypertrophic cardiomyopathy	0.001	0.993	0.007
T43.6 Psychostimulants with abuse potential	0.007	0.993	0.000
E10 Insulin-dependent diabetes mellitus	0.007	0.993	0.000
B34.1 Enterovirus infection, unspecified	0.000	0.993	0.007
I34.0 Mitral (valve) insufficiency	0.000	0.993	0.007
T43.9 Psychotropic drug, unspecified	0.007	0.993	0.000
T36 Poisoning by systemic antibiotics	0.007	0.993	0.000
I11 Hypertensive heart disease	0.000	0.993	0.007
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.007	0.993	0.000
K73.9 Chronic hepatitis, unspecified	0.000	0.993	0.007
U89.8 Agent resistant to other single specified antibiotic	0.000	0.993	0.007
K71.6 Toxic liver disease with hepatitis, not elsewhere classified	0.000	0.993	0.007
K73.8 Other chronic hepatitis, not elsewhere classified	0.000	0.993	0.007
I13 Hypertensive heart and renal disease	0.000	0.993	0.007
E10.4 With neurological complications	0.007	0.993	0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.007	0.993	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.000	0.993	0.007
T49.9 Topical agent, unspecified	0.006	0.993	0.000
T49.8 Other topical agents	0.006	0.993	0.000
T49.7 Dental drugs, topically applied	0.006	0.993	0.000
T49.6 Otorhinolaryngological drugs and preparations	0.006	0.993	0.000
T49.5 Ophthalmological drugs and preparations	0.006	0.993	0.000
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.006	0.993	0.000
T49.3 Emollients, demulcents and protectants	0.006	0.993	0.000
T49.2 Local astringents and local detergents	0.006	0.993	0.000
T49.1 Antipruritics	0.006	0.993	0.000
K71.0 Toxic liver disease with cholestasis	0.000	0.994	0.006
T47.6 Antidiarrhoeal drugs	0.006	0.994	0.000
E10.5 With peripheral circulatory complications	0.006	0.994	0.000
T41.5 Therapeutic gases	0.006	0.994	0.000
T41.4 Anaesthetic, unspecified	0.006	0.994	0.000
T41.3 Local anaesthetics	0.006	0.994	0.000
T41.2 Other and unspecified general anaesthetics	0.006	0.994	0.000
T41.1 Intravenous anaesthetics	0.006	0.994	0.000
T41.0 Inhaled anaesthetics	0.006	0.994	0.000
I12 Hypertensive renal disease	0.000	0.994	0.006
I12.9 Hypertensive renal disease without renal failure	0.000	0.994	0.006
T38.1 Thyroid hormones and substitutes	0.006	0.994	0.000
Q23 Congenital malformations of aortic and mitral valves	0.006	0.994	0.000
Q23.1 Congenital insufficiency of aortic valve	0.006	0.994	0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified	0.000	0.994	0.006
K71.1 Toxic liver disease with hepatic necrosis	0.000	0.994	0.006
T38.0 Glucocorticoids and synthetic analogues	0.006	0.994	0.000
T40.5 Cocaine	0.006	0.994	0.000
I78.8 Other diseases of capillaries	0.000	0.994	0.006
K73.1 Chronic lobular hepatitis, not elsewhere classified	0.000	0.994	0.006
K73.0 Chronic persistent hepatitis, not elsewhere classified	0.000	0.994	0.006
T38.9 Other and unspecified hormone antagonists	0.006	0.994	0.000
T38.7 Androgens and anabolic congeners	0.006	0.994	0.000
T38.5 Other oestrogens and progestogens	0.006	0.994	0.000
T38.4 Oral contraceptives	0.006	0.994	0.000
T38.2 Antithyroid drugs	0.006	0.994	0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.006	0.994	0.000
K71.8 Toxic liver disease with other disorders of liver	0.000	0.994	0.006
K71.7 Toxic liver disease with fibrosis and cirrhosis of liver	0.000	0.994	0.006
K71.5 Toxic liver disease with chronic active hepatitis	0.000	0.994	0.006
K71.4 Toxic liver disease with chronic lobular hepatitis	0.000	0.994	0.006
K71.3 Toxic liver disease with chronic persistent hepatitis	0.000	0.994	0.006
K71.2 Toxic liver disease with acute hepatitis	0.000	0.994	0.006
E10.2 With renal complications	0.006	0.994	0.000
H26 Other cataract	0.000	0.994	0.006
T47.2 Stimulant laxatives	0.006	0.994	0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.006	0.994	0.000
T47.8 Other agents primarily affecting the gastro-intestinal system	0.006	0.994	0.000
T47.7 Emetics	0.006	0.994	0.000
T47.5 Digestants	0.006	0.994	0.000
T47.3 Saline and osmotic laxatives	0.006	0.994	0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system	0.006	0.994	0.000
T48.4 Expectorants	0.006	0.994	0.000
T48.3 Antitussives	0.006	0.994	0.000
T48.2 Other and unspecified agents primarily acting on muscles	0.006	0.994	0.000
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.006	0.994	0.000
T48.0 Oxytocic drugs	0.006	0.994	0.000
K77.8 Liver disorders in other diseases classified elsewhere	0.000	0.994	0.006
K77.0 Liver disorders in infectious and parasitic diseases classified elsewhere	0.000	0.994	0.006
I72.3 Aneurysm of iliac artery	0.000	0.994	0.006
T40.3 Methadone	0.006	0.994	0.000
T45.2 Vitamins, not elsewhere classified	0.006	0.994	0.000
T48.5 Anti-common-cold drugs	0.006	0.994	0.000
T38.8 Other and unspecified hormones and their synthetic substitutes	0.006	0.994	0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]	0.006	0.994	0.000
T40.8 Lysergide [LSD]	0.006	0.994	0.000
T40.7 Cannabis (derivatives)	0.006	0.994	0.000
T40.1 Heroin	0.006	0.994	0.000
T40.0 Opium	0.006	0.994	0.000
I72 Other aneurysm	0.000	0.994	0.006
Q28.2 Arteriovenous malformation of cerebral vessels	0.006	0.994	0.000
I71 Aortic aneurysm and dissection	0.000	0.994	0.006
I11.0 Hypertensive heart disease with (congestive) heart failure	0.000	0.994	0.006
I97 Postprocedural disorders of circulatory system, not elsewhere classified	0.000	0.994	0.005
Q23.3 Congenital mitral insufficiency	0.005	0.994	0.000
T40.6 Other and unspecified narcotics	0.005	0.994	0.000
T47.0 Histamine H(2)-receptor antagonists	0.005	0.994	0.000
T48.6 Antiasthmatics, not elsewhere classified	0.005	0.994	0.000
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified	0.005	0.994	0.000
T43.4 Butyrophenone and thioxanthene neuroleptics	0.005	0.994	0.000
T47.4 Other laxatives	0.005	0.994	0.000
Q28 Other congenital malformations of circulatory system	0.005	0.994	0.000
T47.1 Other antacids and anti-gastric-secretion drugs	0.005	0.994	0.000
I05-I09 Chronic rheumatic heart diseases	0.000	0.994	0.005
T45.9 Primarily systemic and haematological agent, unspecified	0.005	0.995	0.000
T45.8 Other primarily systemic and haematological agents	0.005	0.995	0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants	0.005	0.995	0.000
T45.6 Fibrinolysis-affecting drugs	0.005	0.995	0.000
T45.4 Iron and its compounds	0.005	0.995	0.000
T45.3 Enzymes, not elsewhere classified	0.005	0.995	0.000
Q27 Other congenital malformations of peripheral vascular system	0.005	0.995	0.000
Q23.0 Congenital stenosis of aortic valve	0.005	0.995	0.000
T45.5 Anticoagulants	0.005	0.995	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.005	0.995	0.000
H26.1 Traumatic cataract	0.000	0.995	0.005
E10.0 With coma	0.005	0.995	0.000
T36.4 Tetracyclines	0.005	0.995	0.000
T36.9 Systemic antibiotic, unspecified	0.005	0.995	0.000
T36.8 Other systemic antibiotics	0.005	0.995	0.000
T36.7 Antifungal antibiotics, systemically used	0.005	0.995	0.000
T36.6 Rifamycins	0.005	0.995	0.000
T36.5 Aminoglycosides	0.005	0.995	0.000
T36.2 Chloramphenicol group	0.005	0.995	0.000
T36.1 Cefalosporins and other Beta-lactam antibiotics	0.005	0.995	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.005	0.995	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.005	0.995	0.000
I71.3 Abdominal aortic aneurysm, ruptured	0.000	0.995	0.005
K75 Other inflammatory liver diseases	0.000	0.995	0.005
K71.9 Toxic liver disease, unspecified	0.000	0.995	0.005
I11.9 Hypertensive heart disease without (congestive) heart failure	0.000	0.995	0.005
Q27.8 Other specified congenital malformations of peripheral vascular system	0.005	0.995	0.000
E10.7 With multiple complications	0.005	0.995	0.000
H26.0 Infantile, juvenile and presenile cataract	0.000	0.995	0.005
E10.8 With unspecified complications	0.005	0.995	0.000
E10.6 With other specified complications	0.005	0.995	0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.000	0.995	0.005
I13.9 Hypertensive heart and renal disease, unspecified	0.000	0.995	0.005
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure	0.000	0.995	0.005
I13.1 Hypertensive heart and renal disease with renal failure	0.000	0.995	0.005
I13.0 Hypertensive heart and renal disease with (congestive) heart failure	0.000	0.995	0.005
T40.2 Other opioids	0.005	0.995	0.000
K73.2 Chronic active hepatitis, not elsewhere classified	0.000	0.995	0.005
I28 Other diseases of pulmonary vessels	0.000	0.995	0.005
I72.1 Aneurysm of artery of upper extremity	0.000	0.995	0.005
T36.3 Macrolides	0.005	0.995	0.000
I51 Complications and ill-defined descriptions of heart disease	0.000	0.995	0.005
U89 Agent resistant to other and unspecified antibiotics	0.000	0.995	0.005
T43.5 Other and unspecified antipsychotics and neuroleptics	0.005	0.995	0.000
I72.2 Aneurysm of renal artery	0.000	0.995	0.005
K72 Hepatic failure, not elsewhere classified	0.000	0.995	0.005
I51.8 Other ill-defined heart diseases	0.000	0.995	0.005
T45.1 Antineoplastic and immunosuppressive drugs	0.005	0.995	0.000
Q23.9 Congenital malformation of aortic and mitral valves, unspecified	0.005	0.995	0.000
Q23.8 Other congenital malformations of aortic and mitral valves	0.005	0.995	0.000
Q23.4 Hypoplastic left heart syndrome	0.005	0.995	0.000
Q23.2 Congenital mitral stenosis	0.005	0.995	0.000
T40.4 Other synthetic narcotics	0.005	0.995	0.000
K75.3 Granulomatous hepatitis, not elsewhere classified	0.000	0.995	0.005
Q28.0 Arteriovenous malformation of precerebral vessels	0.005	0.995	0.000
I73 Other peripheral vascular diseases	0.000	0.995	0.005
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.000	0.995	0.004
I46.9 Cardiac arrest, unspecified	0.000	0.995	0.005
Q27.3 Peripheral arteriovenous malformation	0.005	0.995	0.000
Z95.1 Presence of aortocoronary bypass graft	0.000	0.995	0.005
Q25 Congenital malformations of great arteries	0.005	0.995	0.000
E10.1 With ketoacidosis	0.005	0.995	0.000
H26.3 Drug-induced cataract	0.000	0.995	0.004
B27.9 Infectious mononucleosis, unspecified	0.000	0.995	0.004
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture	0.000	0.995	0.004
T45.0 Antiallergic and antiemetic drugs	0.004	0.996	0.000
Q27.9 Congenital malformation of peripheral vascular system, unspecified	0.004	0.996	0.000
B27 Infectious mononucleosis	0.000	0.996	0.004
I72.6 Aneurysm and dissection of vertebral artery	0.000	0.996	0.004
I72.5 Aneurysm and dissection of other precerebral arteries	0.000	0.996	0.004
T42.1 Iminostilbenes	0.004	0.996	0.000
K70 Alcoholic liver disease	0.000	0.996	0.004
B25-B34 Other viral diseases	0.000	0.996	0.004
I71.8 Aortic aneurysm of unspecified site, ruptured	0.000	0.996	0.004
I71.5 Thoracoabdominal aortic aneurysm, ruptured	0.000	0.996	0.004
I71.1 Thoracic aortic aneurysm, ruptured	0.000	0.996	0.004
I71.0 Dissection of aorta [any part]	0.000	0.996	0.004
Q24 Other congenital malformations of heart	0.004	0.996	0.000
T36.0 Penicillins	0.004	0.996	0.000
T46.3 Coronary vasodilators, not elsewhere classified	0.004	0.996	0.000
I74.9 Embolism and thrombosis of unspecified artery	0.000	0.996	0.004
Q28.9 Congenital malformation of circulatory system, unspecified	0.004	0.996	0.000
Q28.8 Other specified congenital malformations of circulatory system	0.004	0.996	0.000
Q28.1 Other malformations of precerebral vessels	0.004	0.996	0.000
D25.9 Leiomyoma of uterus, unspecified	0.000	0.996	0.004
Q27.4 Congenital phlebectasia	0.004	0.996	0.000
Q27.2 Other congenital malformations of renal artery	0.004	0.996	0.000
Q27.1 Congenital renal artery stenosis	0.004	0.996	0.000
Q27.0 Congenital absence and hypoplasia of umbilical artery	0.004	0.996	0.000
I97.2 Postmastectomy lymphoedema syndrome	0.000	0.996	0.004
Q24.0 Dextrocardia	0.004	0.996	0.000
Q26 Congenital malformations of great veins	0.004	0.996	0.000
Q20 Congenital malformations of cardiac chambers and connexions	0.004	0.996	0.000
I72.8 Aneurysm of other specified arteries	0.000	0.996	0.004
I74 Arterial embolism and thrombosis	0.000	0.996	0.004
T42.3 Barbiturates	0.004	0.996	0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.004	0.996	0.000
T42.5 Mixed antiepileptics, not elsewhere classified	0.004	0.996	0.000
T42.2 Succinimides and oxazolidinediones	0.004	0.996	0.000
I73.8 Other specified peripheral vascular diseases	0.000	0.996	0.004
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.004	0.996	0.000
T46.8 Antivaricose drugs, including sclerosing agents	0.004	0.996	0.000
T46.7 Peripheral vasodilators	0.004	0.996	0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.004	0.996	0.000
I15 Secondary hypertension	0.000	0.996	0.004
K75.2 Nonspecific reactive hepatitis	0.000	0.996	0.004
K75.1 Phlebitis of portal vein	0.000	0.996	0.004
U89.9 Agent resistant to unspecified antibiotic	0.000	0.996	0.004
I28.8 Other specified diseases of pulmonary vessels	0.000	0.996	0.004
Q25.0 Patent ductus arteriosus	0.004	0.996	0.000
I70 Atherosclerosis	0.000	0.996	0.004
E28.2 Polycystic ovarian syndrome	0.000	0.996	0.004
I95 Hypotension	0.000	0.996	0.004
I46.0 Cardiac arrest with successful resuscitation	0.000	0.996	0.004
T39.1 4-Aminophenol derivatives	0.004	0.996	0.000
I28.0 Arteriovenous fistula of pulmonary vessels	0.000	0.996	0.004
K75.0 Abscess of liver	0.000	0.996	0.004
I09 Other rheumatic heart diseases	0.000	0.996	0.004
Q22 Congenital malformations of pulmonary and tricuspid valves	0.004	0.996	0.000
I28.1 Aneurysm of pulmonary artery	0.000	0.996	0.004
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.004	0.996	0.000
I51.2 Rupture of papillary muscle, not elsewhere classified	0.000	0.996	0.004
I73.9 Peripheral vascular disease, unspecified	0.000	0.996	0.004
Q28.3 Other malformations of cerebral vessels	0.004	0.996	0.000
I51.5 Myocardial degeneration	0.000	0.996	0.004
I06 Rheumatic aortic valve diseases	0.000	0.996	0.004
T46.1 Calcium-channel blockers	0.004	0.996	0.000
Q25.4 Other congenital malformations of aorta	0.004	0.996	0.000
T46.4 Angiotensin-converting-enzyme inhibitors	0.004	0.996	0.000
I51.3 Intracardiac thrombosis, not elsewhere classified	0.000	0.996	0.004
Q25.3 Stenosis of aorta	0.004	0.996	0.000
I97.0 Postcardiotomy syndrome	0.000	0.996	0.003
I97.1 Other functional disturbances following cardiac surgery	0.000	0.996	0.003
I79.1 Aortitis in diseases classified elsewhere	0.000	0.996	0.003
I79.0 Aneurysm of aorta in diseases classified elsewhere	0.000	0.996	0.003
Q24.6 Congenital heart block	0.004	0.996	0.000
Q24.4 Congenital subaortic stenosis	0.004	0.996	0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.003	0.996	0.000
I07 Rheumatic tricuspid valve diseases	0.000	0.996	0.004
I28.9 Disease of pulmonary vessels, unspecified	0.000	0.996	0.003
I95.0 Idiopathic hypotension	0.000	0.996	0.004
I97.9 Postprocedural disorder of circulatory system, unspecified	0.000	0.996	0.003
K72.0 Acute and subacute hepatic failure	0.000	0.996	0.003
Q25.9 Congenital malformation of great arteries, unspecified	0.003	0.996	0.000
Q25.8 Other congenital malformations of great arteries	0.003	0.996	0.000
Q25.7 Other congenital malformations of pulmonary artery	0.003	0.996	0.000
Q25.5 Atresia of pulmonary artery	0.003	0.996	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations