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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs301
log Bayes Factor = 5.37678
Chromosome 8   position 19,816,934  (GRCh37) Explore rs301 on Ensembl!
Variant rs301 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.001 0.999
I21 Acute myocardial infarction
0.000 0.006 0.994
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.007 0.993
I22 Subsequent myocardial infarction
0.000 0.008 0.992
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.026 0.974
I21.9 Acute myocardial infarction, unspecified
0.000 0.031 0.969
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.036 0.964
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.085 0.915
E78.0 Pure hypercholesterolaemia
0.000 0.091 0.909
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.098 0.902
E78.2 Mixed hyperlipidaemia
0.000 0.099 0.901
E78.5 Hyperlipidaemia, unspecified
0.000 0.102 0.898
I25.4 Coronary artery aneurysm
0.000 0.109 0.891
I25.2 Old myocardial infarction
0.000 0.111 0.889
I77 Other disorders of arteries and arterioles
0.000 0.121 0.879
I77.1 Stricture of artery
0.000 0.122 0.878
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.123 0.877
I71 Aortic aneurysm and dissection
0.000 0.152 0.848
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.152 0.848
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.153 0.847
I24 Other acute ischaemic heart diseases
0.000 0.155 0.845
I73 Other peripheral vascular diseases
0.000 0.166 0.834
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.172 0.828
E78.1 Pure hyperglyceridaemia
0.000 0.179 0.821
I73.9 Peripheral vascular disease, unspecified
0.000 0.187 0.813
I21.4 Acute subendocardial myocardial infarction
0.000 0.197 0.803
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.203 0.797
I70 Atherosclerosis
0.000 0.212 0.788
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.213 0.787
I77.8 Other specified disorders of arteries and arterioles
0.000 0.226 0.774
I71.0 Dissection of aorta [any part]
0.000 0.239 0.761
I73.8 Other specified peripheral vascular diseases
0.000 0.247 0.753
E78.4 Other hyperlipidaemia
0.000 0.249 0.751
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.252 0.748
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.277 0.723
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.279 0.721
I77.0 Arteriovenous fistula, acquired
0.000 0.283 0.717
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.287 0.712
I25.5 Ischaemic cardiomyopathy
0.000 0.289 0.711
Chapter IX Diseases of the circulatory system
0.000 0.304 0.696
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.000 0.317 0.683
I71.3 Abdominal aortic aneurysm, ruptured
0.000 0.319 0.681
I23 Certain current complications following acute myocardial infarction
0.000 0.320 0.680
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.327 0.673
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.332 0.668
E78.6 Lipoprotein deficiency
0.000 0.340 0.660
I77.2 Rupture of artery
0.000 0.342 0.658
E78.3 Hyperchylomicronaemia
0.000 0.344 0.656
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.367 0.633
I77.5 Necrosis of artery
0.000 0.370 0.630
I77.4 Coeliac artery compression syndrome
0.000 0.370 0.630
I77.3 Arterial fibromuscular dysplasia
0.000 0.370 0.630
I71.8 Aortic aneurysm of unspecified site, ruptured
0.000 0.392 0.608
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.000 0.392 0.608
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.000 0.392 0.608
I71.1 Thoracic aortic aneurysm, ruptured
0.000 0.392 0.608
I70.1 Atherosclerosis of renal artery
0.000 0.394 0.606
I70.0 Atherosclerosis of aorta
0.000 0.406 0.594
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.413 0.587
I70.9 Generalised and unspecified atherosclerosis
0.000 0.435 0.565
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.435 0.564
I79.1 Aortitis in diseases classified elsewhere
0.000 0.435 0.564
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.435 0.564
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.000 0.446 0.554
I25.3 Aneurysm of heart
0.000 0.458 0.542
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.459 0.541
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.461 0.539
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.477 0.523
I74 Arterial embolism and thrombosis
0.000 0.491 0.509
I24.1 Dressler's syndrome
0.000 0.494 0.506
E78.8 Other disorders of lipoprotein metabolism
0.000 0.499 0.500
I78 Diseases of capillaries
0.000 0.507 0.493
I22.8 Subsequent myocardial infarction of other sites
0.000 0.512 0.488
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.512 0.487
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.512 0.487
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.512 0.487
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.512 0.487
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.512 0.487
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.512 0.487
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.512 0.487
I24.8 Other forms of acute ischaemic heart disease
0.000 0.513 0.487
I70.8 Atherosclerosis of other arteries
0.000 0.514 0.486
I00-I02 Acute rheumatic fever
0.000 0.515 0.485
I70.10 Atherosclerosis of renal artery (without gangrene)
0.000 0.524 0.476
I20 Angina pectoris
0.000 0.534 0.466
I25.6 Silent myocardial ischaemia
0.001 0.543 0.456
I70.00 Atherosclerosis of aorta (without gangrene)
0.000 0.546 0.454
I23.8 Other current complications following acute myocardial infarction
0.000 0.549 0.450
I77.6 Arteritis, unspecified
0.000 0.559 0.441
I74.8 Embolism and thrombosis of other arteries
0.000 0.562 0.438
I70.11 Atherosclerosis of renal artery (with gangrene)
0.000 0.565 0.435
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.570 0.430
I70.01 Atherosclerosis of aorta (with gangrene)
0.000 0.574 0.426
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.000 0.595 0.405
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.000 0.595 0.405
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.595 0.404
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.599 0.401
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.606 0.394
I97.2 Postmastectomy lymphoedema syndrome
0.000 0.638 0.362
I20.9 Angina pectoris, unspecified
0.000 0.643 0.357
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.643 0.357
I20.0 Unstable angina
0.000 0.643 0.357
I78.9 Disease of capillaries, unspecified
0.000 0.647 0.353
I70.81 Atherosclerosis of other arteries (with gangrene)
0.000 0.651 0.348
I02 Rheumatic chorea
0.000 0.652 0.348
I01 Rheumatic fever with heart involvement
0.000 0.652 0.348
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.653 0.346
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.656 0.344
I97.1 Other functional disturbances following cardiac surgery
0.000 0.656 0.344
I00 Rheumatic fever without mention of heart involvement
0.000 0.665 0.335
I78.8 Other diseases of capillaries
0.000 0.702 0.298
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.705 0.295
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.706 0.294
I97.9 Postprocedural disorder of circulatory system, unspecified
0.000 0.712 0.287
I97.0 Postcardiotomy syndrome
0.000 0.712 0.287
I74.5 Embolism and thrombosis of iliac artery
0.000 0.716 0.284
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.723 0.277
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.725 0.275
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.727 0.273
I70.80 Atherosclerosis of other arteries (without gangrene)
0.001 0.730 0.269
I72 Other aneurysm
0.000 0.732 0.267
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.746 0.254
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.750 0.250
I01.8 Other acute rheumatic heart disease
0.000 0.750 0.250
I01.2 Acute rheumatic myocarditis
0.000 0.750 0.250
I01.1 Acute rheumatic endocarditis
0.000 0.750 0.250
I01.0 Acute rheumatic pericarditis
0.000 0.750 0.250
I02.9 Rheumatic chorea without heart involvement
0.000 0.750 0.250
I02.0 Rheumatic chorea with heart involvement
0.000 0.750 0.250
I99 Other and unspecified disorders of circulatory system
0.000 0.752 0.248
I20.1 Angina pectoris with documented spasm
0.000 0.769 0.231
I05-I09 Chronic rheumatic heart diseases
0.000 0.778 0.222
I28 Other diseases of pulmonary vessels
0.000 0.784 0.216
I78.1 Naevus, nonneoplastic
0.000 0.785 0.215
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.794 0.206
I72.4 Aneurysm of artery of lower extremity
0.000 0.794 0.206
I72.2 Aneurysm of renal artery
0.000 0.798 0.202
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.808 0.192
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.808 0.192
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.000 0.810 0.190
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.000 0.817 0.182
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.817 0.182
I98.0 Cardiovascular syphilis
0.000 0.817 0.182
I72.9 Aneurysm of unspecified site
0.000 0.818 0.181
I72.1 Aneurysm of artery of upper extremity
0.000 0.821 0.178
I26 Pulmonary embolism
0.000 0.831 0.168
I07 Rheumatic tricuspid valve diseases
0.000 0.834 0.166
I09 Other rheumatic heart diseases
0.000 0.839 0.160
I28.8 Other specified diseases of pulmonary vessels
0.000 0.841 0.158
I72.3 Aneurysm of iliac artery
0.000 0.843 0.156
I28.9 Disease of pulmonary vessels, unspecified
0.000 0.845 0.155
I28.1 Aneurysm of pulmonary artery
0.000 0.845 0.155
I28.0 Arteriovenous fistula of pulmonary vessels
0.000 0.845 0.155
I20.8 Other forms of angina pectoris
0.000 0.846 0.154
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.000 0.857 0.143
I06 Rheumatic aortic valve diseases
0.000 0.862 0.137
I05 Rheumatic mitral valve diseases
0.000 0.870 0.130
I07.1 Tricuspid insufficiency
0.000 0.874 0.126
I07.9 Tricuspid valve disease, unspecified
0.000 0.881 0.119
I07.8 Other tricuspid valve diseases
0.000 0.881 0.119
I07.2 Tricuspid stenosis with insufficiency
0.000 0.881 0.119
I07.0 Tricuspid stenosis
0.000 0.881 0.119
I09.9 Rheumatic heart disease, unspecified
0.000 0.883 0.116
I72.0 Aneurysm of carotid artery
0.001 0.885 0.115
I09.8 Other specified rheumatic heart diseases
0.000 0.885 0.115
I09.2 Chronic rheumatic pericarditis
0.000 0.885 0.115
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.000 0.885 0.115
I09.0 Rheumatic myocarditis
0.000 0.885 0.115
I98.2 Oesophageal varices in diseases classified elsewhere
0.000 0.886 0.114
I72.8 Aneurysm of other specified arteries
0.001 0.888 0.111
I05.1 Rheumatic mitral insufficiency
0.000 0.891 0.109
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.901 0.099
I06.8 Other rheumatic aortic valve diseases
0.000 0.901 0.099
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.901 0.099
I06.1 Rheumatic aortic insufficiency
0.000 0.901 0.099
I27 Other pulmonary heart diseases
0.000 0.903 0.097
I05.8 Other mitral valve diseases
0.000 0.906 0.093
I05.0 Mitral stenosis
0.000 0.913 0.087
I10-I15 Hypertensive diseases
0.000 0.917 0.083
I06.0 Rheumatic aortic stenosis
0.001 0.923 0.077
I95 Hypotension
0.000 0.927 0.073
I05.2 Mitral stenosis with insufficiency
0.000 0.928 0.072
I27.8 Other specified pulmonary heart diseases
0.000 0.930 0.070
I05.9 Mitral valve disease, unspecified
0.000 0.930 0.070
I27.1 Kyphoscoliotic heart disease
0.000 0.930 0.070
I27.9 Pulmonary heart disease, unspecified
0.000 0.937 0.063
I11 Hypertensive heart disease
0.000 0.941 0.058
I13 Hypertensive heart and renal disease
0.000 0.943 0.056
I95.8 Other hypotension
0.000 0.944 0.056
I73.0 Raynaud's syndrome
0.000 0.946 0.053
I27.0 Primary pulmonary hypertension
0.000 0.951 0.049
I95.0 Idiopathic hypotension
0.000 0.951 0.049
N90 Other noninflammatory disorders of vulva and perineum
0.000 0.952 0.048
N90.4 Leukoplakia of vulva
0.000 0.952 0.048
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.953 0.047
N90.9 Noninflammatory disorder of vulva and perineum, unspecified
0.000 0.953 0.047
I15 Secondary hypertension
0.000 0.954 0.046
N90.7 Vulvar cyst
0.000 0.955 0.045
N90.5 Atrophy of vulva
0.000 0.956 0.044
N90.6 Hypertrophy of vulva
0.000 0.958 0.042
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.959 0.041
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.959 0.041
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.959 0.041
N90.1 Moderate vulvar dysplasia
0.000 0.962 0.038
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.963 0.037
I95.1 Orthostatic hypotension
0.000 0.964 0.036
G50.0 Trigeminal neuralgia
0.000 0.964 0.036
N90.2 Severe vulvar dysplasia, not elsewhere classified
0.000 0.965 0.035
N90.0 Mild vulvar dysplasia
0.000 0.965 0.035
I15.8 Other secondary hypertension
0.000 0.966 0.033
I15.2 Hypertension secondary to endocrine disorders
0.000 0.966 0.033
I15.1 Hypertension secondary to other renal disorders
0.000 0.967 0.033
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.967 0.033
I27.2 Other secondary pulmonary hypertension
0.000 0.968 0.032
N90.3 Dysplasia of vulva, unspecified
0.000 0.969 0.030
I15.0 Renovascular hypertension
0.000 0.972 0.028
I15.9 Seconday hypertension, unspecified
0.000 0.972 0.027
I08 Multiple valve diseases
0.001 0.976 0.023
I95.2 Hypotension due to drugs
0.000 0.977 0.022
I08.8 Other multiple valve diseases
0.000 0.980 0.020
N90.8 Other specified noninflammatory disorders of vulva and perineum
0.000 0.980 0.020
I12 Hypertensive renal disease
0.000 0.981 0.018
I08.9 Multiple valve disease, unspecified
0.000 0.982 0.018
R16.1 Splenomegaly, not elsewhere classified
0.016 0.984 0.000
I95.9 Hypotension, unspecified
0.000 0.984 0.016
G50 Disorders of trigeminal nerve
0.000 0.985 0.015
E70-E90 Metabolic disorders
0.000 0.988 0.012
I08.2 Disorders of both aortic and tricuspid valves
0.001 0.988 0.011
G50.1 Atypical facial pain
0.000 0.989 0.011
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
0.000 0.989 0.011
G50.8 Other disorders of trigeminal nerve
0.000 0.989 0.011
I63 Cerebral infarction
0.000 0.990 0.010
I60-I69 Cerebrovascular diseases
0.000 0.990 0.010
G50.9 Disorder of trigeminal nerve, unspecified
0.000 0.990 0.010
E73 Lactose intolerance
0.000 0.990 0.010
E85 Amyloidosis
0.000 0.990 0.010
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.000 0.990 0.010
I63.3 Cerebral infarction due to thrombosis of cerebral arteries
0.000 0.991 0.009
E79 Disorders of purine and pyrimidine metabolism
0.000 0.991 0.009
E74 Other disorders of carbohydrate metabolism
0.000 0.991 0.009
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.991 0.009
I63.8 Other cerebral infarction
0.000 0.991 0.009
E84 Cystic fibrosis
0.000 0.991 0.009
E77 Disorders of glycoprotein metabolism
0.000 0.991 0.009
E76 Disorders of glycosaminoglycan metabolism
0.000 0.991 0.009
E72 Other disorders of amino-acid metabolism
0.000 0.991 0.009
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.991 0.009
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.991 0.009
E88 Other metabolic disorders
0.000 0.991 0.009
E73.9 Lactose intolerance, unspecified
0.000 0.992 0.008
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.992 0.008
E85.4 Organ-limited amyloidosis
0.000 0.992 0.008
I63.0 Cerebral infarction due to thrombosis of precerebral arteries
0.000 0.992 0.008
M25.57 Pain in joint (Ankle and foot)
0.000 0.992 0.008
E70 Disorders of aromatic amino-acid metabolism
0.000 0.992 0.008
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
0.000 0.992 0.008
I63.1 Cerebral infarction due to embolism of precerebral arteries
0.000 0.992 0.008
K08.3 Retained dental root
0.000 0.992 0.008
E85.3 Secondary systemic amyloidosis
0.000 0.992 0.007
R16 Hepatomegaly and splenomegaly, not elsewhere classified
0.007 0.993 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.000 0.993 0.007
H74.3 Other acquired abnormalities of ear ossicles
0.000 0.993 0.007
H74.9 Disorder of middle ear and mastoid, unspecified
0.000 0.993 0.007
E73.8 Other lactose intolerance
0.000 0.993 0.007
E73.1 Secondary lactase deficiency
0.000 0.993 0.007
E73.0 Congenital lactase deficiency
0.000 0.993 0.007
E85.8 Other amyloidosis
0.000 0.993 0.007
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.993 0.007
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.993 0.007
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.993 0.007
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.993 0.007
E85.9 Amyloidosis, unspecified
0.000 0.993 0.007
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.993 0.007
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.993 0.007
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.993 0.007
H74 Other disorders of middle ear and mastoid
0.000 0.993 0.007
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.993 0.007
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.993 0.007
E79.1 Lesch-Nyhan syndrome
0.000 0.993 0.007
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.993 0.007
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.993 0.007
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.993 0.007
E74.2 Disorders of galactose metabolism
0.000 0.993 0.007
E74.1 Disorders of fructose metabolism
0.000 0.993 0.007
E74.0 Glycogen storage disease
0.000 0.993 0.007
H72 Perforation of tympanic membrane
0.000 0.993 0.007
E71.3 Disorders of fatty-acid metabolism
0.000 0.993 0.006
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.993 0.006
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.993 0.006
E71.0 Maple-syrup-urine disease
0.000 0.993 0.006
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.993 0.006
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.993 0.006
E72.5 Disorders of glycine metabolism
0.000 0.993 0.006
E72.4 Disorders of ornithine metabolism
0.000 0.993 0.006
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.993 0.006
E72.2 Disorders of urea cycle metabolism
0.000 0.993 0.006
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.993 0.006
E72.0 Disorders of amino-acid transport
0.000 0.993 0.006
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.993 0.006
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.993 0.006
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.993 0.006
E76.2 Other mucopolysaccharidoses
0.000 0.993 0.006
E76.1 Mucopolysaccharidosis, type II
0.000 0.993 0.006
E76.0 Mucopolysaccharidosis, type I
0.000 0.993 0.006
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.993 0.006
E77.8 Other disorders of glycoprotein metabolism
0.000 0.993 0.006
E77.1 Defects in glycoprotein degradation
0.000 0.993 0.006
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.993 0.006
E84.9 Cystic fibrosis, unspecified
0.000 0.993 0.006
E84.8 Cystic fibrosis with other manifestations
0.000 0.993 0.006
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.993 0.006
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.993 0.006
H72.0 Central perforation of tympanic membrane
0.000 0.993 0.007
E88.9 Metabolic disorder, unspecified
0.000 0.993 0.006
E88.3 Tumour lysis syndrome
0.000 0.993 0.006
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.993 0.006
O99.8 Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
0.000 0.993 0.007
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.000 0.994 0.006
E88.8 Other specified metabolic disorders
0.000 0.994 0.006
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.006 0.994 0.000
I63.4 Cerebral infarction due to embolism of cerebral arteries
0.000 0.994 0.006
R16.2 Hepatomegaly with splenomegaly, not elsewhere classified
0.006 0.994 0.000
E75.6 Lipid storage disorder, unspecified
0.000 0.994 0.006
E75.5 Other lipid storage disorders
0.000 0.994 0.006
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.994 0.006
E75.3 Sphingolipidosis, unspecified
0.000 0.994 0.006
E75.1 Other gangliosidosis
0.000 0.994 0.006
E75.0 GM2 gangliosidosis
0.000 0.994 0.006
E88.2 Lipomatosis, not elsewhere classified
0.000 0.994 0.006
H65-H75 Diseases of middle ear and mastoid
0.000 0.994 0.006
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.994 0.006
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.994 0.006
E70.2 Disorders of tyrosine metabolism
0.000 0.994 0.006
E70.1 Other hyperphenylalaninaemias
0.000 0.994 0.006
E70.0 Classical phenylketonuria
0.000 0.994 0.006
K58.0 Irritable bowel syndrome with diarrhoea
0.000 0.994 0.006
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.000 0.994 0.006
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.000 0.994 0.005
I68.0 Cerebral amyloid angiopathy
0.000 0.994 0.005
I68.8 Other cerebrovascular disorders in diseases classified elsewhere
0.000 0.994 0.005
I68.2 Cerebral arteritis in other diseases classified elsewhere
0.000 0.994 0.005
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere
0.000 0.994 0.005
H72.1 Attic perforation of tympanic membrane
0.000 0.994 0.006
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.994 0.006
H70.9 Mastoiditis, unspecified
0.000 0.994 0.005
E86 Volume depletion
0.000 0.994 0.006
H70 Mastoiditis and related conditions
0.000 0.994 0.005
H66 Suppurative and unspecified otitis media
0.000 0.995 0.005
E75.2 Other sphingolipidosis
0.000 0.995 0.005
E80.2 Other porphyria
0.000 0.995 0.005
H72.8 Other perforations of tympanic membrane
0.000 0.995 0.005
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.000 0.995 0.005
I83 Varicose veins of lower extremities
0.000 0.995 0.005
E11.9 Without complications
0.000 0.995 0.005
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.995 0.005
E80.5 Crigler-Najjar syndrome
0.000 0.995 0.005
E80.3 Defects of catalase and peroxydase
0.000 0.995 0.005
E80.0 Hereditary erythropoietic porphyria
0.000 0.995 0.005
R16.0 Hepatomegaly, not elsewhere classified
0.005 0.995 0.000
E11.5 With peripheral circulatory complications
0.000 0.995 0.005
I12.9 Hypertensive renal disease without renal failure
0.001 0.995 0.005
H72.9 Perforation of tympanic membrane, unspecified
0.000 0.995 0.005
H72.2 Other marginal perforations of tympanic membrane
0.000 0.995 0.005
I83.0 Varicose veins of lower extremities with ulcer
0.000 0.995 0.005
I87 Other disorders of veins
0.000 0.995 0.005
I87.1 Compression of vein
0.000 0.995 0.005
H74.4 Polyp of middle ear
0.000 0.995 0.005
H74.2 Discontinuity and dislocation of ear ossicles
0.000 0.995 0.005
E80.4 Gilbert's syndrome
0.000 0.995 0.005
E70.3 Albinism
0.000 0.995 0.005
H74.8 Other specified disorders of middle ear and mastoid
0.000 0.995 0.005
H73 Other disorders of tympanic membrane
0.000 0.995 0.005
M70.65 Trochanteric bursitis-Pelvic/Thigh
0.000 0.995 0.005
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries
0.000 0.995 0.005
I81 Portal vein thrombosis
0.000 0.995 0.005
I62 Other nontraumatic intracranial haemorrhage
0.000 0.995 0.005
E80.1 Porphyria cutanea tarda
0.000 0.995 0.004
H66.9 Otitis media, unspecified
0.000 0.995 0.005
H74.1 Adhesive middle ear disease
0.000 0.995 0.004
K42.9 Umbilical hernia without obstruction or gangrene
0.000 0.995 0.005
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.000 0.995 0.004
H68 Eustachian salpingitis and obstruction
0.000 0.995 0.004
H67 Otitis media in diseases classified elsewhere
0.000 0.995 0.004
H66.3 Other chronic suppurative otitis media
0.000 0.996 0.004
I66.9 Occlusion and stenosis of unspecified cerebral artery
0.000 0.996 0.004
I65.9 Occlusion and stenosis of unspecified precerebral artery
0.000 0.996 0.004
I65.1 Occlusion and stenosis of basilar artery
0.000 0.996 0.004
I66.8 Occlusion and stenosis of other cerebral artery
0.000 0.996 0.004
I66.3 Occlusion and stenosis of cerebellar arteries
0.000 0.996 0.004
I66.2 Occlusion and stenosis of posterior cerebral artery
0.000 0.996 0.004
I66.1 Occlusion and stenosis of anterior cerebral artery
0.000 0.996 0.004
H66.1 Chronic tubotympanic suppurative otitis media
0.000 0.996 0.004
H66.4 Suppurative otitis media, unspecified
0.000 0.996 0.004
H73.8 Other specified disorders of tympanic membrane
0.000 0.996 0.004
S20.8 Superficial injuries of other and unspecified parts of thorax
0.004 0.996 0.000
H71 Cholesteatoma of middle ear
0.000 0.996 0.004
H66.2 Chronic atticoantral suppurative otitis media
0.000 0.996 0.004
I88 Nonspecific lymphadenitis
0.000 0.996 0.004
E11 Non-insulin-dependent diabetes mellitus
0.000 0.996 0.004
H70.2 Petrositis
0.000 0.996 0.004
H70.0 Acute mastoiditis
0.000 0.996 0.004
E80.6 Other disorders of bilirubin metabolism
0.000 0.996 0.004
C67.5 Bladder neck
0.004 0.996 0.000
H66.0 Acute suppurative otitis media
0.000 0.996 0.004
C18.9 Colon, unspecified
0.000 0.996 0.004
H70.8 Other mastoiditis and related conditions
0.000 0.996 0.004
I87.9 Disorder of vein, unspecified
0.000 0.996 0.004
I87.0 Postphlebitic syndrome
0.000 0.996 0.004
H70.1 Chronic mastoiditis
0.000 0.996 0.004
E11.1 With ketoacidosis
0.000 0.996 0.004
H74.0 Tympanosclerosis
0.000 0.996 0.004
I66.4 Occlusion and stenosis of multiple and bilateral cerebral arteries
0.001 0.996 0.003
I65.8 Occlusion and stenosis of other precerebral artery
0.000 0.996 0.004
I65.2 Occlusion and stenosis of carotid artery
0.000 0.996 0.004
H73.1 Chronic myringitis
0.000 0.996 0.004
H73.0 Acute myringitis
0.000 0.996 0.004
I65.0 Occlusion and stenosis of vertebral artery
0.000 0.996 0.004
I87.8 Other specified disorders of veins
0.000 0.996 0.004
I62.1 Nontraumatic extradural haemorrhage
0.000 0.996 0.003
I66.0 Occlusion and stenosis of middle cerebral artery
0.001 0.996 0.003
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.996 0.004
S20.2 Contusion of thorax
0.004 0.996 0.000
H67.8 Otitis media in other diseases classified elsewhere
0.000 0.996 0.003
H67.1 Otitis media in viral diseases classified elsewhere
0.000 0.996 0.003
H67.0 Otitis media in bacterial diseases classified elsewhere
0.000 0.996 0.003
H68.1 Obstruction of Eustachian tube
0.000 0.996 0.003
H68.0 Eustachian salpingitis
0.000 0.996 0.003
H75.8 Other specified disorders of middle ear and mastoid in diseases classified elsewhere
0.000 0.996 0.003
H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere
0.000 0.996 0.003
K08.8 Other specified disorders of teeth and supporting structures
0.000 0.996 0.004
I08.0 Disorders of both mitral and aortic valves
0.001 0.997 0.003
E11.0 With coma
0.000 0.997 0.003
C67.1 Dome of bladder
0.003 0.997 0.000
C67 Malignant neoplasm of bladder
0.003 0.997 0.000
H73.9 Disorder of tympanic membrane, unspecified
0.000 0.997 0.003
I88.1 Chronic lymphadenitis, except mesenteric
0.000 0.997 0.003
K08 Other disorders of teeth and supporting structures
0.000 0.997 0.003
E11.8 With unspecified complications
0.000 0.997 0.003
O00.1 Tubal pregnancy
0.003 0.997 0.000
Z13.6 Special screening examination for cardiovascular disorders
0.003 0.997 0.000
H69 Other disorders of Eustachian tube
0.000 0.997 0.003
E11.7 With multiple complications
0.000 0.997 0.003
I83.1 Varicose veins of lower extremities with inflammation
0.000 0.997 0.003
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.000 0.997 0.003
I85 Oesophageal varices
0.000 0.997 0.003
I88.8 Other nonspecific lymphadenitis
0.000 0.997 0.003
I88.0 Nonspecific mesenteric lymphadenitis
0.000 0.997 0.003
S20 Superficial injury of thorax
0.003 0.997 0.000
E11.3 With ophthalmic complications
0.000 0.997 0.003
E11.2 With renal complications
0.000 0.997 0.003
G97.8 Other postprocedural disorders of nervous system
0.000 0.997 0.003
C67.2 Lateral wall of bladder
0.003 0.997 0.000
A04.8 Other specified bacterial intestinal infections
0.000 0.997 0.003
I62.9 Intracranial haemorrhage (nontraumatic), unspecified
0.000 0.997 0.003
I88.9 Nonspecific lymphadenitis, unspecified
0.000 0.997 0.003
O14.9 Preeclampsia, unspecified
0.003 0.997 0.000
O03.4 Incomplete, without complication
0.000 0.997 0.003
J36 Peritonsillar abscess
0.003 0.997 0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.997 0.003
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.997 0.003
E89.5 Postprocedural testicular hypofunction
0.000 0.997 0.003
E89.1 Postprocedural hypoinsulinaemia
0.000 0.997 0.003
K25.3 Acute without haemorrhage or perforation
0.003 0.997 0.000
G97.1 Other reaction to spinal and lumbar puncture
0.000 0.997 0.003
C67.6 Ureteric orifice
0.003 0.997 0.000
L27.0 Generalised skin eruption due to drugs and medicaments
0.000 0.997 0.003
E11.6 With other specified complications
0.000 0.997 0.003
E89.3 Postprocedural hypopituitarism
0.000 0.997 0.003
I51.9 Heart disease, unspecified
0.000 0.997 0.003
C67.8 Overlapping lesion of bladder
0.003 0.997 0.000
C67.7 Urachus
0.003 0.997 0.000
C67.0 Trigone of bladder
0.003 0.997 0.000
K08.0 Exfoliation of teeth due to systemic causes
0.000 0.997 0.003
H69.0 Patulous Eustachian tube
0.000 0.997 0.002
C67.4 Posterior wall of bladder
0.003 0.997 0.000
E89.4 Postprocedural ovarian failure
0.000 0.997 0.002
C67.3 Anterior wall of bladder
0.003 0.997 0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.997 0.002
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.000 0.997 0.003
E89.2 Postprocedural hypoparathyroidism
0.000 0.997 0.002
G97.0 Cerebrospinal fluid leak from spinal puncture
0.000 0.997 0.003
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.000 0.997 0.003
C67.9 Bladder, unspecified
0.003 0.997 0.000
S20.7 Multiple superficial injuries of thorax
0.002 0.997 0.000
W19.4 Street and highway
0.003 0.997 0.000
S06.20 Diffuse brain injury (without open intracranial wound)
0.000 0.997 0.002
H20.9 Iridocyclitis, unspecified
0.002 0.997 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.001 0.997 0.002
H69.8 Other specified disorders of Eustachian tube
0.000 0.998 0.002
S20.1 Other and unspecified superficial injuries of breast
0.002 0.998 0.000
I87.2 Venous insufficiency (chronic) (peripheral)
0.000 0.998 0.002
S20.4 Other superficial injuries of back wall of thorax
0.002 0.998 0.000
S20.0 Contusion of breast
0.002 0.998 0.000
M90.75 Fracture of bone in neoplastic disease (Pelvic region and thigh)
0.002 0.998 0.000
L43.9 Lichen planus, unspecified
0.002 0.998 0.000
N94.8 Other specified conditions associated with female genital organs and menstrual cycle
0.000 0.998 0.002
S06.30 Focal brain injury (without open intracranial wound)
0.000 0.998 0.002
H05.2 Exophthalmic conditions
0.002 0.998 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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