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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3093948
log Bayes Factor = 67.4826
Chromosome 6   position 31,501,413  (GRCh37) Explore rs3093948 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.003 0.997
I20 Angina pectoris
0.000 0.006 0.994
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.007 0.993
E14.9 Without complications
0.000 0.008 0.992
E14.3 With ophthalmic complications
0.000 0.008 0.992
E10.1 With ketoacidosis
0.000 0.010 0.990
I25.5 Ischaemic cardiomyopathy
0.000 0.011 0.989
E10.4 With neurological complications
0.000 0.015 0.985
I20.9 Angina pectoris, unspecified
0.000 0.016 0.984
I22 Subsequent myocardial infarction
0.000 0.016 0.984
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.022 0.978
E70-E90 Metabolic disorders
0.000 0.028 0.972
E83.1 Disorders of iron metabolism
0.970 0.030 0.000
I25.2 Old myocardial infarction
0.000 0.035 0.965
G35-G37 Demyelinating diseases of the central nervous system
0.962 0.038 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.041 0.959
I20.0 Unstable angina
0.000 0.041 0.959
G37 Other demyelinating diseases of central nervous system
0.955 0.045 0.000
E00-E07 Disorders of thyroid gland
0.000 0.055 0.945
I21 Acute myocardial infarction
0.000 0.057 0.943
G37.9 Demyelinating disease of central nervous system, unspecified
0.935 0.065 0.000
E13 Other specified diabetes mellitus
0.000 0.073 0.927
R07.4 Chest pain, unspecified
0.000 0.073 0.927
E78.8 Other disorders of lipoprotein metabolism
0.000 0.074 0.926
E03 Other hypothyroidism
0.000 0.075 0.925
E03.9 Hypothyroidism, unspecified
0.000 0.082 0.918
I24 Other acute ischaemic heart diseases
0.000 0.087 0.913
I21.9 Acute myocardial infarction, unspecified
0.000 0.097 0.903
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.098 0.902
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.099 0.901
L40-L45 Papulosquamous disorders
0.000 0.107 0.893
E10.2 With renal complications
0.000 0.111 0.889
E11.2 With renal complications
0.000 0.114 0.886
E13.9 Without complications
0.000 0.125 0.875
E11.0 With coma
0.000 0.128 0.872
E05.9 Thyrotoxicosis, unspecified
0.000 0.129 0.871
L43 Lichen planus
0.000 0.131 0.869
E78.2 Mixed hyperlipidaemia
0.000 0.138 0.862
G37.8 Other specified demyelinating diseases of central nervous system
0.852 0.148 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.149 0.851
E11.1 With ketoacidosis
0.000 0.154 0.846
L40.8 Other psoriasis
0.000 0.155 0.845
L43.9 Lichen planus, unspecified
0.000 0.158 0.842
I25.3 Aneurysm of heart
0.000 0.161 0.839
E10.5 With peripheral circulatory complications
0.000 0.168 0.832
I21.4 Acute subendocardial myocardial infarction
0.000 0.168 0.832
E14.4 With neurological complications
0.000 0.173 0.827
E10.8 With unspecified complications
0.000 0.175 0.825
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.178 0.822
E85 Amyloidosis
0.000 0.186 0.813
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.196 0.804
E10.0 With coma
0.000 0.202 0.798
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.206 0.794
I24.8 Other forms of acute ischaemic heart disease
0.000 0.207 0.793
I23 Certain current complications following acute myocardial infarction
0.000 0.221 0.779
L40.0 Psoriasis vulgaris
0.000 0.228 0.772
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.766 0.234 0.000
E11.6 With other specified complications
0.000 0.237 0.763
E16 Other disorders of pancreatic internal secretion
0.000 0.240 0.760
E78.6 Lipoprotein deficiency
0.000 0.242 0.757
E74 Other disorders of carbohydrate metabolism
0.000 0.244 0.756
E78.5 Hyperlipidaemia, unspecified
0.000 0.259 0.741
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.259 0.741
E10.6 With other specified complications
0.000 0.261 0.739
E14.5 With peripheral circulatory complications
0.000 0.263 0.737
E78.1 Pure hyperglyceridaemia
0.000 0.267 0.733
E14.6 With other specified complications
0.000 0.275 0.724
L43.8 Other lichen planus
0.000 0.277 0.723
E10.7 With multiple complications
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.2 Withrenal complications
0.000 0.283 0.717
E14.1 With ketoacidosis
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.288 0.712
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.295 0.704
I10 Essential (primary) hypertension
0.000 0.299 0.701
E79 Disorders of purine and pyrimidine metabolism
0.000 0.300 0.700
L40.3 Pustulosis palmaris et plantaris
0.000 0.303 0.697
E77 Disorders of glycoprotein metabolism
0.000 0.303 0.697
E76 Disorders of glycosaminoglycan metabolism
0.000 0.303 0.697
E72 Other disorders of amino-acid metabolism
0.000 0.303 0.697
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.303 0.697
E70 Disorders of aromatic amino-acid metabolism
0.000 0.303 0.697
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.303 0.697
E85.9 Amyloidosis, unspecified
0.000 0.305 0.695
E11.5 With peripheral circulatory complications
0.000 0.307 0.693
G36 Other acute disseminated demyelination
0.692 0.308 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.311 0.689
G37.5 Concentric sclerosis [Balo]
0.685 0.315 0.000
G37.4 Subacute necrotising myelitis
0.685 0.315 0.000
G37.2 Central pontine myelinolysis
0.685 0.315 0.000
G37.1 Central demyelination of corpus callosum
0.685 0.315 0.000
G37.0 Diffuse sclerosis
0.685 0.315 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.323 0.677
E00 Congenital iodine-deficiency syndrome
0.000 0.323 0.677
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.323 0.676
E16.2 Hypoglycaemia, unspecified
0.000 0.325 0.675
E13.8 With unspecified complications
0.000 0.335 0.665
E13.7 With multiple complications
0.000 0.335 0.665
E13.6 With other specified complications
0.000 0.335 0.665
E13.5 With peripheral circulatory complications
0.000 0.335 0.665
E13.4 With neurological complications
0.000 0.335 0.665
E13.3 With ophthalmic complications
0.000 0.335 0.665
E13.2 With renal complications
0.000 0.335 0.665
E13.1 With ketoacidosis
0.000 0.335 0.665
E13.0 With coma
0.000 0.335 0.665
E03.5 Myxoedema coma
0.000 0.337 0.663
E03.4 Atrophy of thyroid (acquired)
0.000 0.337 0.663
E03.3 Postinfectious hypothyroidism
0.000 0.337 0.663
E03.1 Congenital hypothyroidism without goitre
0.000 0.337 0.663
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.337 0.663
E78.4 Other hyperlipidaemia
0.000 0.342 0.658
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.343 0.657
L42 Pityriasis rosea
0.000 0.347 0.653
I20.1 Angina pectoris with documented spasm
0.000 0.352 0.648
E05.5 Thyroid crisis or storm
0.000 0.354 0.646
E05.4 Thyrotoxicosis factitia
0.000 0.354 0.646
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.354 0.646
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.354 0.646
I22.8 Subsequent myocardial infarction of other sites
0.000 0.356 0.644
I10-I15 Hypertensive diseases
0.000 0.358 0.642
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.359 0.641
L44 Other papulosquamous disorders
0.000 0.360 0.640
L41 Parapsoriasis
0.000 0.360 0.640
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.360 0.640
E84 Cystic fibrosis
0.000 0.360 0.640
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.361 0.638
E07 Other disorders of thyroid
0.000 0.362 0.638
L43.3 Subacute (active) lichen planus
0.000 0.377 0.623
L43.2 Lichenoid drug reaction
0.000 0.377 0.623
L43.1 Bullous lichen planus
0.000 0.377 0.623
L43.0 Hypertrophic lichen planus
0.000 0.377 0.623
I23.8 Other current complications following acute myocardial infarction
0.000 0.379 0.621
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.380 0.620
E40-E46 Malnutrition
0.000 0.384 0.616
E15 Nondiabetic hypoglycaemic coma
0.000 0.390 0.610
E11.4 With neurological complications
0.000 0.392 0.608
E85.4 Organ-limited amyloidosis
0.000 0.398 0.602
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.398 0.602
E16.1 Other hypoglycaemia
0.000 0.398 0.602
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.404 0.596
I25.4 Coronary artery aneurysm
0.000 0.410 0.590
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.412 0.587
E85.8 Other amyloidosis
0.000 0.417 0.583
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.417 0.583
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.417 0.583
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.417 0.583
E85.3 Secondary systemic amyloidosis
0.000 0.426 0.574
E73 Lactose intolerance
0.000 0.426 0.574
E89.3 Postprocedural hypopituitarism
0.000 0.433 0.567
I15 Secondary hypertension
0.000 0.440 0.560
E06 Thyroiditis
0.000 0.441 0.559
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.441 0.559
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.441 0.559
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.441 0.559
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.441 0.559
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.441 0.559
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.441 0.559
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.441 0.559
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.455 0.545
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.455 0.545
E16.4 Abnormal secretion of gastrin
0.000 0.455 0.545
E16.3 Increased secretion of glucagon
0.000 0.455 0.545
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.458 0.542
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.458 0.542
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.458 0.542
E74.2 Disorders of galactose metabolism
0.000 0.458 0.542
E74.1 Disorders of fructose metabolism
0.000 0.458 0.542
E74.0 Glycogen storage disease
0.000 0.458 0.542
I12 Hypertensive renal disease
0.000 0.462 0.538
E83 Disorders of mineral metabolism
0.434 0.463 0.103
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.463 0.537
E05.8 Other thyrotoxicosis
0.000 0.466 0.534
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.471 0.529
E11.3 With ophthalmic complications
0.000 0.475 0.525
I24.1 Dressler's syndrome
0.000 0.475 0.525
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.477 0.523
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E11.8 With unspecified complications
0.000 0.490 0.510
I11 Hypertensive heart disease
0.000 0.492 0.508
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.495 0.504
I15.1 Hypertension secondary to other renal disorders
0.000 0.497 0.503
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.498 0.502
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.498 0.502
E79.1 Lesch-Nyhan syndrome
0.000 0.498 0.502
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.500 0.499
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.500 0.499
E70.3 Albinism
0.000 0.500 0.499
E70.2 Disorders of tyrosine metabolism
0.000 0.500 0.499
E70.1 Other hyperphenylalaninaemias
0.000 0.500 0.499
E70.0 Classical phenylketonuria
0.000 0.500 0.499
E71.3 Disorders of fatty-acid metabolism
0.000 0.500 0.499
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.500 0.499
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.500 0.499
E71.0 Maple-syrup-urine disease
0.000 0.500 0.499
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.500 0.499
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.500 0.499
E72.5 Disorders of glycine metabolism
0.000 0.500 0.499
E72.4 Disorders of ornithine metabolism
0.000 0.500 0.499
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.500 0.499
E72.2 Disorders of urea cycle metabolism
0.000 0.500 0.499
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.500 0.499
E72.0 Disorders of amino-acid transport
0.000 0.500 0.499
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.500 0.499
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.500 0.499
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.500 0.499
E76.2 Other mucopolysaccharidoses
0.000 0.500 0.499
E76.1 Mucopolysaccharidosis, type II
0.000 0.500 0.499
E76.0 Mucopolysaccharidosis, type I
0.000 0.500 0.499
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.500 0.499
E77.8 Other disorders of glycoprotein metabolism
0.000 0.500 0.499
E77.1 Defects in glycoprotein degradation
0.000 0.500 0.499
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.500 0.499
G36.0 Neuromyelitis optica [Devic]
0.498 0.502 0.000
G36.9 Acute disseminated demyelination, unspecified
0.496 0.504 0.000
G36.8 Other specified acute disseminated demyelination
0.496 0.504 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.496 0.504 0.000
E75.6 Lipid storage disorder, unspecified
0.000 0.506 0.494
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.506 0.494
E75.3 Sphingolipidosis, unspecified
0.000 0.506 0.494
E75.2 Other sphingolipidosis
0.000 0.506 0.494
E75.1 Other gangliosidosis
0.000 0.506 0.494
E75.0 GM2 gangliosidosis
0.000 0.506 0.494
E88 Other metabolic disorders
0.000 0.510 0.490
E75.5 Other lipid storage disorders
0.000 0.514 0.486
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.514 0.486
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.514 0.486
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.514 0.486
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.514 0.486
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.514 0.486
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.514 0.486
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.514 0.486
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.514 0.486
I12.9 Hypertensive renal disease without renal failure
0.000 0.518 0.482
E07.8 Other specified disorders of thyroid
0.000 0.539 0.461
I13 Hypertensive heart and renal disease
0.000 0.540 0.460
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.541 0.459
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.541 0.459
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.541 0.459
E89.5 Postprocedural testicular hypofunction
0.000 0.541 0.459
E89.1 Postprocedural hypoinsulinaemia
0.000 0.541 0.459
L41.9 Parapsoriasis, unspecified
0.000 0.541 0.459
L41.8 Other parapsoriasis
0.000 0.541 0.459
L41.5 Retiform parapsoriasis
0.000 0.541 0.459
L41.4 Large plaque parapsoriasis
0.000 0.541 0.459
L41.3 Small plaque parapsoriasis
0.000 0.541 0.459
L41.2 Lymphomatoid papulosis
0.000 0.541 0.459
L41.1 Pityriasis lichenoides chronica
0.000 0.541 0.459
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.541 0.459
L44.9 Papulosquamous disorder, unspecified
0.000 0.541 0.459
L44.8 Other specified papulosquamous disorders
0.000 0.541 0.459
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.541 0.459
L44.3 Lichen ruber moniliformis
0.000 0.541 0.459
L44.2 Lichen striatus
0.000 0.541 0.459
L44.1 Lichen nitidus
0.000 0.541 0.459
L44.0 Pityriasis rubra pilaris
0.000 0.541 0.459
E84.8 Cystic fibrosis with other manifestations
0.000 0.541 0.459
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.541 0.459
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.541 0.459
E65-E68 Obesity and other hyperalimentation
0.000 0.541 0.459
E07.1 Dyshormogenetic goitre
0.000 0.542 0.458
E07.0 Hypersecretion of calcitonin
0.000 0.542 0.458
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.558 0.442
E45 Retarded development following protein-energy malnutrition
0.000 0.558 0.442
E43 Unspecified severe protein-energy malnutrition
0.000 0.558 0.442
E42 Marasmic kwashiorkor
0.000 0.558 0.442
E41 Nutritional marasmus
0.000 0.558 0.442
E40 Kwashiorkor
0.000 0.558 0.442
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.566 0.434
E89.4 Postprocedural ovarian failure
0.000 0.566 0.433
E50-E64 Other nutritional deficiencies
0.000 0.582 0.418
Chapter IX Diseases of the circulatory system
0.000 0.583 0.417
E07.9 Disorder of thyroid, unspecified
0.000 0.586 0.414
E73.8 Other lactose intolerance
0.000 0.588 0.411
E73.1 Secondary lactase deficiency
0.000 0.588 0.411
E73.0 Congenital lactase deficiency
0.000 0.588 0.411
E83.3 Disorders of phosphorus metabolism
0.375 0.593 0.032
E84.9 Cystic fibrosis, unspecified
0.000 0.598 0.401
I15.8 Other secondary hypertension
0.000 0.598 0.402
I15.2 Hypertension secondary to endocrine disorders
0.000 0.598 0.402
I15.0 Renovascular hypertension
0.000 0.598 0.402
E06.5 Other chronic thyroiditis
0.000 0.599 0.401
E06.4 Drug-induced thyroiditis
0.000 0.599 0.401
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.599 0.401
E06.1 Subacute thyroiditis
0.000 0.599 0.401
E06.0 Acute thyroiditis
0.000 0.599 0.401
E80.6 Other disorders of bilirubin metabolism
0.000 0.601 0.399
I15.9 Seconday hypertension, unspecified
0.000 0.603 0.396
E88.2 Lipomatosis, not elsewhere classified
0.000 0.608 0.392
E83.9 Disorder of mineral metabolism, unspecified
0.311 0.615 0.074
E83.8 Other disorders of mineral metabolism
0.311 0.615 0.074
E83.2 Disorders of zinc metabolism
0.311 0.615 0.074
E83.0 Disorders of copper metabolism
0.311 0.615 0.074
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.620 0.379
E80.5 Crigler-Najjar syndrome
0.000 0.620 0.379
E80.3 Defects of catalase and peroxydase
0.000 0.620 0.379
E80.2 Other porphyria
0.000 0.620 0.379
E80.1 Porphyria cutanea tarda
0.000 0.620 0.379
E80.0 Hereditary erythropoietic porphyria
0.000 0.620 0.379
K90 Intestinal malabsorption
0.000 0.621 0.379
E03.8 Other specified hypothyroidism
0.001 0.621 0.378
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.625 0.375
E89.2 Postprocedural hypoparathyroidism
0.000 0.630 0.370
E06.9 Thyroiditis, unspecified
0.000 0.631 0.369
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.638 0.362
E46 Unspecified protein-energy malnutrition
0.000 0.643 0.357
E88.8 Other specified metabolic disorders
0.000 0.645 0.354
E88.9 Metabolic disorder, unspecified
0.000 0.648 0.351
E88.3 Tumour lysis syndrome
0.000 0.651 0.349
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.657 0.343
I12.0 Hypertensive renal disease with renal failure
0.000 0.666 0.334
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.670 0.330
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.670 0.330
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.670 0.330
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.670 0.330
E67 Other hyperalimentation
0.000 0.671 0.329
E68 Sequelae of hyperalimentation
0.000 0.671 0.329
E06.3 Autoimmune thyroiditis
0.000 0.671 0.328
E61 Deficiency of other nutrient elements
0.000 0.676 0.324
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.677 0.323
E44.1 Mild protein-energy malnutrition
0.000 0.683 0.317
E44.0 Moderate protein-energy malnutrition
0.000 0.683 0.317
E65 Localised adiposity
0.000 0.687 0.313
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.700 0.300
E63 Other nutritional deficiencies
0.000 0.700 0.300
E51 Thiamine deficiency
0.000 0.700 0.300
E50 Vitamin A deficiency
0.000 0.700 0.300
E60 Dietary zinc deficiency
0.000 0.700 0.300
E59 Dietary selenium deficiency
0.000 0.700 0.300
E58 Dietary calcium deficiency
0.000 0.700 0.300
E54 Ascorbic acid deficiency
0.000 0.700 0.300
E52 Niacin deficiency [pellagra]
0.000 0.700 0.300
E89.0 Postprocedural hypothyroidism
0.000 0.701 0.299
I00-I02 Acute rheumatic fever
0.000 0.701 0.299
E73.9 Lactose intolerance, unspecified
0.001 0.711 0.288
E88.1 Lipodystrophy, not elsewhere classified
0.001 0.715 0.285
E56 Other vitamin deficiencies
0.000 0.717 0.283
K90.9 Intestinal malabsorption, unspecified
0.000 0.726 0.274
K90.8 Other intestinal malabsorption
0.000 0.726 0.274
K90.3 Pancreatic steatorrhoea
0.000 0.728 0.272
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.728 0.272
K90.1 Tropical sprue
0.000 0.728 0.272
E61.1 Iron deficiency
0.000 0.738 0.262
E67.8 Other specified hyperalimentation
0.000 0.764 0.236
E67.3 Hypervitaminosis D
0.000 0.764 0.236
E67.2 Megavitamin-B6 syndrome
0.000 0.764 0.236
E67.1 Hypercarotenaemia
0.000 0.764 0.236
E67.0 Hypervitaminosis A
0.000 0.764 0.236
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.766 0.234
E55 Vitamin D deficiency
0.000 0.767 0.233
E61.9 Deficiency of nutrient element, unspecified
0.000 0.767 0.232
E61.8 Deficiency of other specified nutrient elements
0.000 0.767 0.232
E61.7 Deficiency of multiple nutrient elements
0.000 0.767 0.232
E61.6 Vanadium deficiency
0.000 0.767 0.232
E61.5 Molybdenum deficiency
0.000 0.767 0.232
E61.4 Chromium deficiency
0.000 0.767 0.232
E61.3 Manganese deficiency
0.000 0.767 0.232
E61.0 Copper deficiency
0.000 0.767 0.232
E83.4 Disorders of magnesium metabolism
0.169 0.772 0.059
E61.2 Magnesium deficiency
0.000 0.776 0.224
E20-E35 Disorders of other endocrine glands
0.000 0.778 0.222
E50.9 Vitamin A deficiency, unspecified
0.000 0.785 0.215
E50.8 Other manifestations of vitamin A deficiency
0.000 0.785 0.215
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.785 0.215
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.785 0.215
E50.5 Vitamin A deficiency with night blindness
0.000 0.785 0.215
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.785 0.215
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.785 0.215
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.785 0.215
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.785 0.215
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.785 0.215
E51.9 Thiamine deficiency, unspecified
0.000 0.785 0.215
E51.8 Other manifestations of thiamine deficiency
0.000 0.785 0.215
E51.2 Wernicke's encephalopathy
0.000 0.785 0.215
E51.1 Beriberi
0.000 0.785 0.215
E63.9 Nutritional deficiency, unspecified
0.000 0.785 0.215
E63.8 Other specified nutritional deficiencies
0.000 0.785 0.215
E63.1 Imbalance of constituents of food intake
0.000 0.785 0.215
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.785 0.215
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.785 0.215
E64.8 Sequelae of other nutritional deficiencies
0.000 0.785 0.215
E64.3 Sequelae of rickets
0.000 0.785 0.215
E64.2 Sequelae of vitamin C deficiency
0.000 0.785 0.215
E64.1 Sequelae of vitamin A deficiency
0.000 0.785 0.215
E64.0 Sequelae of protein-energy malnutrition
0.000 0.785 0.215
I02 Rheumatic chorea
0.000 0.785 0.214
I01 Rheumatic fever with heart involvement
0.000 0.785 0.214
I00 Rheumatic fever without mention of heart involvement
0.000 0.785 0.214
E56.9 Vitamin deficiency, unspecified
0.000 0.797 0.203
E56.8 Deficiency of other vitamins
0.000 0.797 0.203
E56.0 Deficiency of vitamin E
0.000 0.797 0.203
E56.1 Deficiency of vitamin K
0.000 0.814 0.185
E23 Hypofunction and other disorders of pituitary gland
0.000 0.819 0.180
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.002 0.823 0.175
E83.5 Disorders of calcium metabolism
0.147 0.833 0.020
E55.0 Rickets, active
0.000 0.833 0.167
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.834 0.166
E22 Hyperfunction of pituitary gland
0.000 0.835 0.165
E80.4 Gilbert's syndrome
0.000 0.836 0.164
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.841 0.159
E32 Diseases of thymus
0.000 0.841 0.159
E31 Polyglandular dysfunction
0.000 0.841 0.159
E30 Disorders of puberty, not elsewhere classified
0.000 0.841 0.159
E25 Adrenogenital disorders
0.000 0.841 0.159
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.001 0.841 0.159
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.846 0.154
I01.8 Other acute rheumatic heart disease
0.000 0.846 0.154
I01.2 Acute rheumatic myocarditis
0.000 0.846 0.154
I01.1 Acute rheumatic endocarditis
0.000 0.846 0.154
I01.0 Acute rheumatic pericarditis
0.000 0.846 0.154
I02.9 Rheumatic chorea without heart involvement
0.000 0.846 0.154
I02.0 Rheumatic chorea with heart involvement
0.000 0.846 0.154
E26 Hyperaldosteronism
0.000 0.847 0.153
E23.6 Other disorders of pituitary gland
0.000 0.847 0.153
E24 Cushing's syndrome
0.000 0.849 0.150
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.851 0.149
E23.2 Diabetes insipidus
0.000 0.851 0.149
E29 Testicular dysfunction
0.000 0.855 0.145
E20 Hypoparathyroidism
0.000 0.856 0.144
E28 Ovarian dysfunction
0.000 0.860 0.140
E53 Deficiency of other B group vitamins
0.001 0.861 0.138
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.864 0.136
I20.8 Other forms of angina pectoris
0.000 0.866 0.134
E23.7 Disorder of pituitary gland, unspecified
0.000 0.868 0.131
M45 Ankylosing spondylitis
0.000 0.870 0.130
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.870 0.130
E23.1 Drug-induced hypopituitarism
0.000 0.870 0.130
E66 Obesity
0.000 0.872 0.128
I28 Other diseases of pulmonary vessels
0.001 0.874 0.125
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.875 0.125
E34 Other endocrine disorders
0.000 0.881 0.118
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.882 0.118
E22.8 Other hyperfunction of pituitary gland
0.000 0.882 0.118
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.882 0.118
E21.3 Hyperparathyroidism, unspecified
0.000 0.884 0.116
E25.9 Adrenogenital disorder, unspecified
0.000 0.886 0.114
E25.8 Other adrenogenital disorders
0.000 0.886 0.114
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.886 0.114
E30.9 Disorder of puberty, unspecified
0.000 0.886 0.114
E30.8 Other disorders of puberty
0.000 0.886 0.114
E30.1 Precocious puberty
0.000 0.886 0.114
E30.0 Delayed puberty
0.000 0.886 0.114
E31.9 Polyglandular dysfunction, unspecified
0.000 0.886 0.114
E31.8 Other polyglandular dysfunction
0.000 0.886 0.114
E31.1 Polyglandular hyperfunction
0.000 0.886 0.114
E31.0 Autoimmune polyglandular failure
0.000 0.886 0.114
E32.9 Disease of thymus, unspecified
0.000 0.886 0.114
E32.8 Other diseases of thymus
0.000 0.886 0.114
E32.1 Abscess of thymus
0.000 0.886 0.114
E32.0 Persistent hyperplasia of thymus
0.000 0.886 0.114
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.886 0.114
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.886 0.114
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.886 0.114
I27 Other pulmonary heart diseases
0.001 0.889 0.110
E22.1 Hyperprolactinaemia
0.000 0.889 0.110
E26.9 Hyperaldosteronism, unspecified
0.000 0.890 0.110
E26.8 Other hyperaldosteronism
0.000 0.890 0.110
E26.1 Secondary hyperaldosteronism
0.000 0.890 0.110
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.891 0.109
E24.8 Other Cushing's syndrome
0.000 0.892 0.108
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.892 0.108
E24.3 Ectopic ACTH syndrome
0.000 0.892 0.108
E24.2 Drug-induced Cushing's syndrome
0.000 0.892 0.108
E24.1 Nelson's syndrome
0.000 0.892 0.108
E24.0 Pituitary-dependent Cushing's disease
0.000 0.892 0.108
E22.0 Acromegaly and pituitary gigantism
0.000 0.892 0.108
E66.0 Obesity due to excess calories
0.000 0.893 0.107
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.893 0.107

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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