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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3093976
log Bayes Factor = 65.2036
Chromosome 6   position 31,502,861  (GRCh37) Explore rs3093976 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.001 0.999
I25.1 Atherosclerotic heart disease
0.000 0.001 0.999
I20 Angina pectoris
0.000 0.002 0.998
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.004 0.996
I20.9 Angina pectoris, unspecified
0.000 0.008 0.992
E14.9 Without complications
0.000 0.012 0.988
I25.5 Ischaemic cardiomyopathy
0.000 0.012 0.988
E10.1 With ketoacidosis
0.000 0.013 0.987
E14.3 With ophthalmic complications
0.000 0.013 0.987
I20.0 Unstable angina
0.000 0.016 0.984
E10.4 With neurological complications
0.000 0.018 0.982
I22 Subsequent myocardial infarction
0.000 0.021 0.979
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.021 0.979
I25.2 Old myocardial infarction
0.000 0.031 0.969
G35-G37 Demyelinating diseases of the central nervous system
0.955 0.045 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.051 0.949
E83.1 Disorders of iron metabolism
0.949 0.051 0.000
G37 Other demyelinating diseases of central nervous system
0.946 0.054 0.000
I21 Acute myocardial infarction
0.000 0.060 0.940
E13 Other specified diabetes mellitus
0.000 0.071 0.929
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.072 0.928
G37.9 Demyelinating disease of central nervous system, unspecified
0.926 0.074 0.000
E70-E90 Metabolic disorders
0.000 0.079 0.921
I24 Other acute ischaemic heart diseases
0.000 0.089 0.911
E78.8 Other disorders of lipoprotein metabolism
0.000 0.094 0.906
I21.9 Acute myocardial infarction, unspecified
0.000 0.101 0.899
L40-L45 Papulosquamous disorders
0.000 0.104 0.896
I10 Essential (primary) hypertension
0.000 0.105 0.895
E10.2 With renal complications
0.000 0.118 0.882
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.120 0.880
E13.9 Without complications
0.000 0.122 0.878
E11.0 With coma
0.000 0.124 0.876
L43 Lichen planus
0.000 0.125 0.875
E11.2 With renal complications
0.000 0.126 0.874
R07.4 Chest pain, unspecified
0.000 0.129 0.871
L43.9 Lichen planus, unspecified
0.000 0.154 0.846
I25.3 Aneurysm of heart
0.000 0.155 0.845
L40.8 Other psoriasis
0.000 0.159 0.841
E11.1 With ketoacidosis
0.000 0.166 0.834
E78.2 Mixed hyperlipidaemia
0.000 0.166 0.834
G37.8 Other specified demyelinating diseases of central nervous system
0.830 0.170 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.171 0.829
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.176 0.824
E14.4 With neurological complications
0.000 0.176 0.824
E10.5 With peripheral circulatory complications
0.000 0.180 0.820
E10.8 With unspecified complications
0.000 0.181 0.819
I10-I15 Hypertensive diseases
0.000 0.185 0.815
E00-E07 Disorders of thyroid gland
0.000 0.188 0.812
I21.4 Acute subendocardial myocardial infarction
0.000 0.192 0.808
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.202 0.798
E10.0 With coma
0.000 0.207 0.793
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.219 0.781
I24.8 Other forms of acute ischaemic heart disease
0.000 0.219 0.781
L40.0 Psoriasis vulgaris
0.000 0.223 0.777
I23 Certain current complications following acute myocardial infarction
0.000 0.225 0.775
E03 Other hypothyroidism
0.000 0.226 0.774
E11.6 With other specified complications
0.000 0.231 0.769
E03.9 Hypothyroidism, unspecified
0.000 0.237 0.763
E85 Amyloidosis
0.000 0.241 0.759
E16 Other disorders of pancreatic internal secretion
0.000 0.251 0.749
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.253 0.747
E78.6 Lipoprotein deficiency
0.000 0.257 0.743
L43.8 Other lichen planus
0.000 0.259 0.741
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.734 0.266 0.000
E14.5 With peripheral circulatory complications
0.000 0.266 0.734
E10.6 With other specified complications
0.000 0.266 0.734
E14.6 With other specified complications
0.000 0.279 0.721
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.279 0.721
E74 Other disorders of carbohydrate metabolism
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.2 Withrenal complications
0.000 0.283 0.717
E14.1 With ketoacidosis
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
I15 Secondary hypertension
0.000 0.284 0.716
E05.9 Thyrotoxicosis, unspecified
0.000 0.286 0.714
E78.1 Pure hyperglyceridaemia
0.000 0.287 0.713
E78.5 Hyperlipidaemia, unspecified
0.000 0.296 0.704
E78.3 Hyperchylomicronaemia
0.000 0.298 0.702
E11.5 With peripheral circulatory complications
0.000 0.305 0.695
L40.3 Pustulosis palmaris et plantaris
0.000 0.305 0.694
I12 Hypertensive renal disease
0.000 0.311 0.689
G36 Other acute disseminated demyelination
0.688 0.312 0.000
E16.2 Hypoglycaemia, unspecified
0.000 0.320 0.680
G37.5 Concentric sclerosis [Balo]
0.678 0.322 0.000
G37.4 Subacute necrotising myelitis
0.678 0.322 0.000
G37.2 Central pontine myelinolysis
0.678 0.322 0.000
G37.1 Central demyelination of corpus callosum
0.678 0.322 0.000
G37.0 Diffuse sclerosis
0.678 0.322 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.326 0.674
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.333 0.667
E13.8 With unspecified complications
0.000 0.334 0.666
E13.7 With multiple complications
0.000 0.334 0.666
E13.6 With other specified complications
0.000 0.334 0.666
E13.5 With peripheral circulatory complications
0.000 0.334 0.666
E13.4 With neurological complications
0.000 0.334 0.666
E13.3 With ophthalmic complications
0.000 0.334 0.666
E13.2 With renal complications
0.000 0.334 0.666
E13.1 With ketoacidosis
0.000 0.334 0.666
E13.0 With coma
0.000 0.334 0.666
E78.4 Other hyperlipidaemia
0.000 0.335 0.664
E79 Disorders of purine and pyrimidine metabolism
0.000 0.339 0.661
E77 Disorders of glycoprotein metabolism
0.000 0.339 0.660
E76 Disorders of glycosaminoglycan metabolism
0.000 0.339 0.660
E72 Other disorders of amino-acid metabolism
0.000 0.339 0.660
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.339 0.660
E70 Disorders of aromatic amino-acid metabolism
0.000 0.339 0.660
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.339 0.660
I22.8 Subsequent myocardial infarction of other sites
0.000 0.343 0.657
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.348 0.651
L42 Pityriasis rosea
0.000 0.350 0.650
I15.1 Hypertension secondary to other renal disorders
0.000 0.351 0.649
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.351 0.649
E85.9 Amyloidosis, unspecified
0.000 0.357 0.643
L44 Other papulosquamous disorders
0.000 0.357 0.643
L41 Parapsoriasis
0.000 0.357 0.643
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.357 0.643
L43.3 Subacute (active) lichen planus
0.000 0.373 0.627
L43.2 Lichenoid drug reaction
0.000 0.373 0.627
L43.1 Bullous lichen planus
0.000 0.373 0.627
L43.0 Hypertrophic lichen planus
0.000 0.373 0.627
E11.4 With neurological complications
0.000 0.374 0.626
I11 Hypertensive heart disease
0.000 0.378 0.622
I20.1 Angina pectoris with documented spasm
0.000 0.383 0.617
I12.9 Hypertensive renal disease without renal failure
0.000 0.385 0.614
I23.8 Other current complications following acute myocardial infarction
0.000 0.386 0.614
E84 Cystic fibrosis
0.000 0.395 0.605
E40-E46 Malnutrition
0.000 0.403 0.597
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.404 0.595
E15 Nondiabetic hypoglycaemic coma
0.000 0.409 0.591
E16.1 Other hypoglycaemia
0.000 0.410 0.590
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.415 0.585
I13 Hypertensive heart and renal disease
0.000 0.416 0.584
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.418 0.582
E00 Congenital iodine-deficiency syndrome
0.000 0.418 0.582
I25.4 Coronary artery aneurysm
0.000 0.419 0.581
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.427 0.573
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.444 0.556
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.444 0.556
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.444 0.556
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.444 0.556
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.444 0.556
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.444 0.556
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.444 0.556
E03.5 Myxoedema coma
0.000 0.445 0.555
E03.4 Atrophy of thyroid (acquired)
0.000 0.445 0.555
E03.3 Postinfectious hypothyroidism
0.000 0.445 0.555
E03.1 Congenital hypothyroidism without goitre
0.000 0.445 0.555
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.445 0.555
E85.4 Organ-limited amyloidosis
0.000 0.445 0.554
E11.3 With ophthalmic complications
0.000 0.449 0.551
E85.8 Other amyloidosis
0.000 0.456 0.544
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.456 0.544
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.456 0.544
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.456 0.544
E73 Lactose intolerance
0.000 0.462 0.537
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.463 0.537
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.463 0.537
E16.4 Abnormal secretion of gastrin
0.000 0.463 0.537
E16.3 Increased secretion of glucagon
0.000 0.463 0.537
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.463 0.537
E05.5 Thyroid crisis or storm
0.000 0.464 0.536
E05.4 Thyrotoxicosis factitia
0.000 0.464 0.536
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.464 0.536
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.464 0.536
E85.3 Secondary systemic amyloidosis
0.000 0.467 0.533
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.467 0.533
E07 Other disorders of thyroid
0.000 0.470 0.530
E89.3 Postprocedural hypopituitarism
0.000 0.478 0.522
Chapter IX Diseases of the circulatory system
0.000 0.480 0.520
I24.1 Dressler's syndrome
0.000 0.480 0.519
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.483 0.517
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.485 0.515
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.485 0.515
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.485 0.515
E74.2 Disorders of galactose metabolism
0.000 0.485 0.515
E74.1 Disorders of fructose metabolism
0.000 0.485 0.515
E74.0 Glycogen storage disease
0.000 0.485 0.515
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
I15.8 Other secondary hypertension
0.000 0.486 0.514
I15.2 Hypertension secondary to endocrine disorders
0.000 0.486 0.514
I15.0 Renovascular hypertension
0.000 0.486 0.514
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.489 0.511
I15.9 Seconday hypertension, unspecified
0.000 0.496 0.503
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.498 0.502
E11.8 With unspecified complications
0.000 0.499 0.500
G36.0 Neuromyelitis optica [Devic]
0.497 0.503 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.505 0.494
G36.9 Acute disseminated demyelination, unspecified
0.493 0.507 0.000
G36.8 Other specified acute disseminated demyelination
0.493 0.507 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.493 0.507 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.517 0.483
E06 Thyroiditis
0.000 0.523 0.477
E83 Disorders of mineral metabolism
0.342 0.525 0.134
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.525 0.474
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.526 0.474
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.526 0.474
E79.1 Lesch-Nyhan syndrome
0.000 0.526 0.474
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.526 0.473
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.526 0.473
E70.3 Albinism
0.000 0.526 0.473
E70.2 Disorders of tyrosine metabolism
0.000 0.526 0.473
E70.1 Other hyperphenylalaninaemias
0.000 0.526 0.473
E70.0 Classical phenylketonuria
0.000 0.526 0.473
E71.3 Disorders of fatty-acid metabolism
0.000 0.526 0.473
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.526 0.473
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.526 0.473
E71.0 Maple-syrup-urine disease
0.000 0.526 0.473
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.526 0.473
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.526 0.473
E72.5 Disorders of glycine metabolism
0.000 0.526 0.473
E72.4 Disorders of ornithine metabolism
0.000 0.526 0.473
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.526 0.473
E72.2 Disorders of urea cycle metabolism
0.000 0.526 0.473
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.526 0.473
E72.0 Disorders of amino-acid transport
0.000 0.526 0.473
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.526 0.473
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.526 0.473
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.526 0.473
E76.2 Other mucopolysaccharidoses
0.000 0.526 0.473
E76.1 Mucopolysaccharidosis, type II
0.000 0.526 0.473
E76.0 Mucopolysaccharidosis, type I
0.000 0.526 0.473
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.526 0.473
E77.8 Other disorders of glycoprotein metabolism
0.000 0.526 0.473
E77.1 Defects in glycoprotein degradation
0.000 0.526 0.473
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.526 0.473
E75.6 Lipid storage disorder, unspecified
0.000 0.533 0.467
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.533 0.467
E75.3 Sphingolipidosis, unspecified
0.000 0.533 0.467
E75.2 Other sphingolipidosis
0.000 0.533 0.467
E75.1 Other gangliosidosis
0.000 0.533 0.467
E75.0 GM2 gangliosidosis
0.000 0.533 0.467
L41.9 Parapsoriasis, unspecified
0.000 0.539 0.461
L41.8 Other parapsoriasis
0.000 0.539 0.461
L41.5 Retiform parapsoriasis
0.000 0.539 0.461
L41.4 Large plaque parapsoriasis
0.000 0.539 0.461
L41.3 Small plaque parapsoriasis
0.000 0.539 0.461
L41.2 Lymphomatoid papulosis
0.000 0.539 0.461
L41.1 Pityriasis lichenoides chronica
0.000 0.539 0.461
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.539 0.461
L44.9 Papulosquamous disorder, unspecified
0.000 0.539 0.461
L44.8 Other specified papulosquamous disorders
0.000 0.539 0.461
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.539 0.461
L44.3 Lichen ruber moniliformis
0.000 0.539 0.461
L44.2 Lichen striatus
0.000 0.539 0.461
L44.1 Lichen nitidus
0.000 0.539 0.461
L44.0 Pityriasis rubra pilaris
0.000 0.539 0.461
E75.5 Other lipid storage disorders
0.000 0.542 0.458
E88 Other metabolic disorders
0.000 0.542 0.457
I12.0 Hypertensive renal disease with renal failure
0.000 0.547 0.453
E65-E68 Obesity and other hyperalimentation
0.000 0.554 0.446
E05.8 Other thyrotoxicosis
0.000 0.561 0.439
E84.8 Cystic fibrosis with other manifestations
0.000 0.566 0.433
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.566 0.433
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.566 0.433
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.572 0.428
E45 Retarded development following protein-energy malnutrition
0.000 0.572 0.428
E43 Unspecified severe protein-energy malnutrition
0.000 0.572 0.428
E42 Marasmic kwashiorkor
0.000 0.572 0.428
E41 Nutritional marasmus
0.000 0.572 0.428
E40 Kwashiorkor
0.000 0.572 0.428
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.573 0.427
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.573 0.427
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.573 0.427
E89.5 Postprocedural testicular hypofunction
0.000 0.573 0.427
E89.1 Postprocedural hypoinsulinaemia
0.000 0.573 0.427
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.581 0.419
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.581 0.419
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.581 0.419
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.581 0.419
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.582 0.418
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.582 0.418
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.582 0.418
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.582 0.418
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.582 0.418
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.582 0.418
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.582 0.418
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.582 0.418
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.586 0.413
E50-E64 Other nutritional deficiencies
0.000 0.592 0.407
E89.4 Postprocedural ovarian failure
0.000 0.599 0.401
K90 Intestinal malabsorption
0.000 0.606 0.394
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.608 0.392
E73.8 Other lactose intolerance
0.000 0.614 0.385
E73.1 Secondary lactase deficiency
0.000 0.614 0.385
E73.0 Congenital lactase deficiency
0.000 0.614 0.385
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.619 0.381
E07.1 Dyshormogenetic goitre
0.000 0.620 0.380
E07.0 Hypersecretion of calcitonin
0.000 0.620 0.380
E07.8 Other specified disorders of thyroid
0.000 0.621 0.378
E84.9 Cystic fibrosis, unspecified
0.001 0.622 0.378
E89.2 Postprocedural hypoparathyroidism
0.000 0.623 0.377
I00-I02 Acute rheumatic fever
0.000 0.627 0.373
E80.6 Other disorders of bilirubin metabolism
0.000 0.629 0.371
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.632 0.368
E88.2 Lipomatosis, not elsewhere classified
0.000 0.636 0.364
E46 Unspecified protein-energy malnutrition
0.000 0.641 0.359
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.645 0.354
E80.5 Crigler-Najjar syndrome
0.000 0.645 0.354
E80.3 Defects of catalase and peroxydase
0.000 0.645 0.354
E80.2 Other porphyria
0.000 0.645 0.354
E80.1 Porphyria cutanea tarda
0.000 0.645 0.354
E80.0 Hereditary erythropoietic porphyria
0.000 0.645 0.354
E06.5 Other chronic thyroiditis
0.000 0.658 0.342
E06.4 Drug-induced thyroiditis
0.000 0.658 0.342
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.658 0.342
E06.1 Subacute thyroiditis
0.000 0.658 0.342
E06.0 Acute thyroiditis
0.000 0.658 0.342
E83.9 Disorder of mineral metabolism, unspecified
0.245 0.659 0.096
E83.8 Other disorders of mineral metabolism
0.245 0.659 0.096
E83.2 Disorders of zinc metabolism
0.245 0.659 0.096
E83.0 Disorders of copper metabolism
0.245 0.659 0.096
E83.3 Disorders of phosphorus metabolism
0.286 0.668 0.046
E07.9 Disorder of thyroid, unspecified
0.000 0.669 0.331
E88.8 Other specified metabolic disorders
0.000 0.670 0.329
E03.8 Other specified hypothyroidism
0.001 0.671 0.328
E88.9 Metabolic disorder, unspecified
0.000 0.672 0.328
E88.3 Tumour lysis syndrome
0.000 0.675 0.324
E06.9 Thyroiditis, unspecified
0.000 0.675 0.325
E67 Other hyperalimentation
0.000 0.680 0.320
E68 Sequelae of hyperalimentation
0.000 0.680 0.320
E65 Localised adiposity
0.000 0.689 0.311
E44.1 Mild protein-energy malnutrition
0.000 0.693 0.307
E44.0 Moderate protein-energy malnutrition
0.000 0.693 0.307
E61 Deficiency of other nutrient elements
0.000 0.695 0.305
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.708 0.292
E63 Other nutritional deficiencies
0.000 0.708 0.292
E56 Other vitamin deficiencies
0.000 0.708 0.292
E51 Thiamine deficiency
0.000 0.708 0.292
E50 Vitamin A deficiency
0.000 0.708 0.292
E60 Dietary zinc deficiency
0.000 0.708 0.292
E59 Dietary selenium deficiency
0.000 0.708 0.292
E58 Dietary calcium deficiency
0.000 0.708 0.292
E54 Ascorbic acid deficiency
0.000 0.708 0.292
E52 Niacin deficiency [pellagra]
0.000 0.708 0.292
E20-E35 Disorders of other endocrine glands
0.000 0.715 0.285
K90.9 Intestinal malabsorption, unspecified
0.000 0.716 0.284
K90.3 Pancreatic steatorrhoea
0.000 0.717 0.283
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.717 0.283
K90.1 Tropical sprue
0.000 0.717 0.283
K90.8 Other intestinal malabsorption
0.000 0.717 0.283
I02 Rheumatic chorea
0.000 0.732 0.267
I01 Rheumatic fever with heart involvement
0.000 0.732 0.267
I00 Rheumatic fever without mention of heart involvement
0.000 0.732 0.267
E88.1 Lipodystrophy, not elsewhere classified
0.001 0.735 0.264
E06.3 Autoimmune thyroiditis
0.000 0.736 0.264
E73.9 Lactose intolerance, unspecified
0.001 0.737 0.263
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.746 0.254
E61.1 Iron deficiency
0.000 0.761 0.239
E89.0 Postprocedural hypothyroidism
0.000 0.761 0.238
E23 Hypofunction and other disorders of pituitary gland
0.000 0.764 0.236
E55 Vitamin D deficiency
0.000 0.768 0.232
E67.8 Other specified hyperalimentation
0.000 0.771 0.229
E67.3 Hypervitaminosis D
0.000 0.771 0.229
E67.2 Megavitamin-B6 syndrome
0.000 0.771 0.229
E67.1 Hypercarotenaemia
0.000 0.771 0.229
E67.0 Hypervitaminosis A
0.000 0.771 0.229
E22 Hyperfunction of pituitary gland
0.000 0.772 0.228
E61.9 Deficiency of nutrient element, unspecified
0.000 0.781 0.219
E61.8 Deficiency of other specified nutrient elements
0.000 0.781 0.219
E61.7 Deficiency of multiple nutrient elements
0.000 0.781 0.219
E61.6 Vanadium deficiency
0.000 0.781 0.219
E61.5 Molybdenum deficiency
0.000 0.781 0.219
E61.4 Chromium deficiency
0.000 0.781 0.219
E61.3 Manganese deficiency
0.000 0.781 0.219
E61.0 Copper deficiency
0.000 0.781 0.219
E50.9 Vitamin A deficiency, unspecified
0.000 0.790 0.210
E50.8 Other manifestations of vitamin A deficiency
0.000 0.790 0.210
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.790 0.210
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.790 0.210
E50.5 Vitamin A deficiency with night blindness
0.000 0.790 0.210
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.790 0.210
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.790 0.210
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.790 0.210
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.790 0.210
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.790 0.210
E51.9 Thiamine deficiency, unspecified
0.000 0.790 0.210
E51.8 Other manifestations of thiamine deficiency
0.000 0.790 0.210
E51.2 Wernicke's encephalopathy
0.000 0.790 0.210
E51.1 Beriberi
0.000 0.790 0.210
E56.9 Vitamin deficiency, unspecified
0.000 0.790 0.210
E56.8 Deficiency of other vitamins
0.000 0.790 0.210
E56.1 Deficiency of vitamin K
0.000 0.790 0.210
E56.0 Deficiency of vitamin E
0.000 0.790 0.210
E63.9 Nutritional deficiency, unspecified
0.000 0.790 0.210
E63.8 Other specified nutritional deficiencies
0.000 0.790 0.210
E63.1 Imbalance of constituents of food intake
0.000 0.790 0.210
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.790 0.210
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.790 0.210
E64.8 Sequelae of other nutritional deficiencies
0.000 0.790 0.210
E64.3 Sequelae of rickets
0.000 0.790 0.210
E64.2 Sequelae of vitamin C deficiency
0.000 0.790 0.210
E64.1 Sequelae of vitamin A deficiency
0.000 0.790 0.210
E64.0 Sequelae of protein-energy malnutrition
0.000 0.790 0.210
E61.2 Magnesium deficiency
0.000 0.790 0.209
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.796 0.204
E32 Diseases of thymus
0.000 0.796 0.204
E31 Polyglandular dysfunction
0.000 0.796 0.204
E30 Disorders of puberty, not elsewhere classified
0.000 0.796 0.204
E25 Adrenogenital disorders
0.000 0.796 0.204
E83.4 Disorders of magnesium metabolism
0.115 0.799 0.086
E26 Hyperaldosteronism
0.000 0.800 0.200
E23.6 Other disorders of pituitary gland
0.000 0.802 0.198
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.804 0.196
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.001 0.804 0.195
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.805 0.195
E23.2 Diabetes insipidus
0.000 0.806 0.193
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.808 0.192
I01.8 Other acute rheumatic heart disease
0.000 0.808 0.192
I01.2 Acute rheumatic myocarditis
0.000 0.808 0.192
I01.1 Acute rheumatic endocarditis
0.000 0.808 0.192
I01.0 Acute rheumatic pericarditis
0.000 0.808 0.192
I02.9 Rheumatic chorea without heart involvement
0.000 0.808 0.192
I02.0 Rheumatic chorea with heart involvement
0.000 0.808 0.192
E29 Testicular dysfunction
0.000 0.809 0.191
E24 Cushing's syndrome
0.000 0.809 0.191
E20 Hypoparathyroidism
0.000 0.817 0.183
E23.7 Disorder of pituitary gland, unspecified
0.000 0.821 0.179
E28 Ovarian dysfunction
0.000 0.824 0.176
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.831 0.169
E23.1 Drug-induced hypopituitarism
0.000 0.831 0.169
E55.0 Rickets, active
0.000 0.833 0.166
E22.1 Hyperprolactinaemia
0.000 0.836 0.164
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.836 0.163
E22.8 Other hyperfunction of pituitary gland
0.000 0.836 0.163
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.841 0.158
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.001 0.845 0.154
E21.3 Hyperparathyroidism, unspecified
0.000 0.847 0.153
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.851 0.149
E22.0 Acromegaly and pituitary gigantism
0.000 0.852 0.148
E80.4 Gilbert's syndrome
0.001 0.852 0.147
E34 Other endocrine disorders
0.000 0.852 0.147
E25.9 Adrenogenital disorder, unspecified
0.000 0.853 0.146
E25.8 Other adrenogenital disorders
0.000 0.853 0.146
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.853 0.146
E30.9 Disorder of puberty, unspecified
0.000 0.853 0.146
E30.8 Other disorders of puberty
0.000 0.853 0.146
E30.1 Precocious puberty
0.000 0.853 0.146
E30.0 Delayed puberty
0.000 0.853 0.146
E31.9 Polyglandular dysfunction, unspecified
0.000 0.853 0.146
E31.8 Other polyglandular dysfunction
0.000 0.853 0.146
E31.1 Polyglandular hyperfunction
0.000 0.853 0.146
E31.0 Autoimmune polyglandular failure
0.000 0.853 0.146
E32.9 Disease of thymus, unspecified
0.000 0.853 0.146
E32.8 Other diseases of thymus
0.000 0.853 0.146
E32.1 Abscess of thymus
0.000 0.853 0.146
E32.0 Persistent hyperplasia of thymus
0.000 0.853 0.146
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.853 0.146
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.853 0.146
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.853 0.146
E26.9 Hyperaldosteronism, unspecified
0.000 0.856 0.144
E26.8 Other hyperaldosteronism
0.000 0.856 0.144
E26.1 Secondary hyperaldosteronism
0.000 0.856 0.144
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.859 0.140
E21.4 Other specified disorders of parathyroid gland
0.000 0.859 0.140
E21.2 Other hyperparathyroidism
0.000 0.859 0.140
E26.0 Primary hyperaldosteronism
0.000 0.860 0.140
E83.5 Disorders of calcium metabolism
0.110 0.861 0.028
I28 Other diseases of pulmonary vessels
0.001 0.861 0.138
E29.9 Testicular dysfunction, unspecified
0.000 0.863 0.137
E29.8 Other testicular dysfunction
0.000 0.863 0.137
E29.0 Testicular hyperfunction
0.000 0.863 0.137
E24.8 Other Cushing's syndrome
0.000 0.863 0.137
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.863 0.137
E24.3 Ectopic ACTH syndrome
0.000 0.863 0.137
E24.2 Drug-induced Cushing's syndrome
0.000 0.863 0.137
E24.1 Nelson's syndrome
0.000 0.863 0.137
E24.0 Pituitary-dependent Cushing's disease
0.000 0.863 0.137
E53 Deficiency of other B group vitamins
0.001 0.868 0.131
E20.8 Other hypoparathyroidism
0.000 0.868 0.131

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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