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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3093978
log Bayes Factor = 65.45
Chromosome 6   position 31,498,497  (GRCh37) Explore rs3093978 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.001 0.999
I25.1 Atherosclerotic heart disease
0.000 0.001 0.999
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.003 0.997
I20 Angina pectoris
0.000 0.006 0.994
I25.5 Ischaemic cardiomyopathy
0.000 0.008 0.992
E14.9 Without complications
0.000 0.011 0.989
E14.3 With ophthalmic complications
0.000 0.011 0.989
E10.1 With ketoacidosis
0.000 0.012 0.988
I22 Subsequent myocardial infarction
0.000 0.013 0.987
E10.4 With neurological complications
0.000 0.018 0.982
I20.9 Angina pectoris, unspecified
0.000 0.020 0.980
I20.0 Unstable angina
0.000 0.025 0.975
G35-G37 Demyelinating diseases of the central nervous system
0.975 0.025 0.000
G37 Other demyelinating diseases of central nervous system
0.970 0.030 0.000
I25.2 Old myocardial infarction
0.000 0.032 0.968
I21 Acute myocardial infarction
0.000 0.035 0.965
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.037 0.963
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.043 0.957
G37.9 Demyelinating disease of central nervous system, unspecified
0.956 0.044 0.000
I10 Essential (primary) hypertension
0.000 0.067 0.933
I21.9 Acute myocardial infarction, unspecified
0.000 0.071 0.929
E13 Other specified diabetes mellitus
0.000 0.072 0.928
E83.1 Disorders of iron metabolism
0.927 0.072 0.000
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.075 0.925
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.079 0.921
E70-E90 Metabolic disorders
0.000 0.088 0.912
I24 Other acute ischaemic heart diseases
0.000 0.111 0.889
E10.2 With renal complications
0.000 0.118 0.882
E78.8 Other disorders of lipoprotein metabolism
0.000 0.121 0.879
E13.9 Without complications
0.000 0.123 0.877
E11.2 With renal complications
0.000 0.126 0.874
E11.1 With ketoacidosis
0.000 0.134 0.866
E11.0 With coma
0.000 0.135 0.865
L40-L45 Papulosquamous disorders
0.000 0.136 0.864
I10-I15 Hypertensive diseases
0.000 0.136 0.864
I21.4 Acute subendocardial myocardial infarction
0.000 0.147 0.853
G37.8 Other specified demyelinating diseases of central nervous system
0.851 0.149 0.000
I25.3 Aneurysm of heart
0.000 0.155 0.845
R07.4 Chest pain, unspecified
0.000 0.155 0.845
L40.8 Other psoriasis
0.000 0.159 0.841
L43 Lichen planus
0.000 0.164 0.836
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.172 0.828
E14.4 With neurological complications
0.000 0.176 0.824
E10.8 With unspecified complications
0.000 0.181 0.819
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.186 0.814
E00-E07 Disorders of thyroid gland
0.000 0.187 0.812
L43.9 Lichen planus, unspecified
0.000 0.197 0.803
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.198 0.802
E10.5 With peripheral circulatory complications
0.000 0.203 0.797
E10.0 With coma
0.000 0.207 0.793
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.793 0.207 0.000
E78.2 Mixed hyperlipidaemia
0.000 0.219 0.781
I23 Certain current complications following acute myocardial infarction
0.000 0.225 0.775
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.228 0.772
E11.6 With other specified complications
0.000 0.232 0.768
L40.0 Psoriasis vulgaris
0.000 0.232 0.768
E16 Other disorders of pancreatic internal secretion
0.000 0.238 0.762
I15 Secondary hypertension
0.000 0.241 0.759
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.246 0.754
E85 Amyloidosis
0.000 0.249 0.751
E03 Other hypothyroidism
0.000 0.249 0.751
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.253 0.747
E05.9 Thyrotoxicosis, unspecified
0.000 0.254 0.746
I24.8 Other forms of acute ischaemic heart disease
0.000 0.257 0.743
I12 Hypertensive renal disease
0.000 0.262 0.738
E14.5 With peripheral circulatory complications
0.000 0.266 0.734
E10.6 With other specified complications
0.000 0.266 0.734
E78.6 Lipoprotein deficiency
0.000 0.269 0.731
E03.9 Hypothyroidism, unspecified
0.000 0.269 0.731
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.272 0.728
E14.6 With other specified complications
0.000 0.279 0.721
E10.7 With multiple complications
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.2 Withrenal complications
0.000 0.283 0.717
E14.1 With ketoacidosis
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
E74 Other disorders of carbohydrate metabolism
0.000 0.289 0.711
G36 Other acute disseminated demyelination
0.702 0.298 0.000
E78.1 Pure hyperglyceridaemia
0.000 0.299 0.701
E16.2 Hypoglycaemia, unspecified
0.000 0.300 0.700
G37.5 Concentric sclerosis [Balo]
0.695 0.305 0.000
G37.4 Subacute necrotising myelitis
0.695 0.305 0.000
G37.2 Central pontine myelinolysis
0.695 0.305 0.000
G37.1 Central demyelination of corpus callosum
0.695 0.305 0.000
G37.0 Diffuse sclerosis
0.695 0.305 0.000
L40.3 Pustulosis palmaris et plantaris
0.000 0.306 0.694
E11.5 With peripheral circulatory complications
0.000 0.306 0.694
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.308 0.692
E78.3 Hyperchylomicronaemia
0.000 0.309 0.690
L43.8 Other lichen planus
0.000 0.310 0.690
I15.1 Hypertension secondary to other renal disorders
0.000 0.312 0.688
I11 Hypertensive heart disease
0.000 0.322 0.678
E13.8 With unspecified complications
0.000 0.334 0.666
E13.7 With multiple complications
0.000 0.334 0.666
E13.6 With other specified complications
0.000 0.334 0.666
E13.5 With peripheral circulatory complications
0.000 0.334 0.666
E13.4 With neurological complications
0.000 0.334 0.666
E13.3 With ophthalmic complications
0.000 0.334 0.666
E13.2 With renal complications
0.000 0.334 0.666
E13.1 With ketoacidosis
0.000 0.334 0.666
E13.0 With coma
0.000 0.334 0.666
I22.8 Subsequent myocardial infarction of other sites
0.000 0.337 0.662
I12.9 Hypertensive renal disease without renal failure
0.000 0.341 0.659
E79 Disorders of purine and pyrimidine metabolism
0.000 0.345 0.654
E77 Disorders of glycoprotein metabolism
0.000 0.346 0.654
E76 Disorders of glycosaminoglycan metabolism
0.000 0.346 0.654
E72 Other disorders of amino-acid metabolism
0.000 0.346 0.654
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.346 0.654
E70 Disorders of aromatic amino-acid metabolism
0.000 0.346 0.654
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.346 0.654
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.346 0.654
E78.4 Other hyperlipidaemia
0.000 0.347 0.653
E11.4 With neurological complications
0.000 0.350 0.650
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.355 0.645
E85.9 Amyloidosis, unspecified
0.000 0.364 0.636
E78.5 Hyperlipidaemia, unspecified
0.000 0.369 0.631
L42 Pityriasis rosea
0.000 0.373 0.627
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.377 0.623
L44 Other papulosquamous disorders
0.000 0.380 0.620
L41 Parapsoriasis
0.000 0.380 0.620
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.380 0.620
I13 Hypertensive heart and renal disease
0.000 0.381 0.619
I23.8 Other current complications following acute myocardial infarction
0.000 0.386 0.614
I20.1 Angina pectoris with documented spasm
0.000 0.386 0.614
L43.3 Subacute (active) lichen planus
0.000 0.401 0.599
L43.2 Lichenoid drug reaction
0.000 0.401 0.599
L43.1 Bullous lichen planus
0.000 0.401 0.599
L43.0 Hypertrophic lichen planus
0.000 0.401 0.599
E16.1 Other hypoglycaemia
0.000 0.401 0.599
E84 Cystic fibrosis
0.000 0.401 0.599
E15 Nondiabetic hypoglycaemic coma
0.000 0.406 0.594
E11.3 With ophthalmic complications
0.000 0.415 0.585
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.417 0.583
E00 Congenital iodine-deficiency syndrome
0.000 0.417 0.583
I25.4 Coronary artery aneurysm
0.000 0.419 0.581
E40-E46 Malnutrition
0.000 0.423 0.577
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.423 0.577
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.427 0.573
Chapter IX Diseases of the circulatory system
0.000 0.433 0.567
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.433 0.566
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.444 0.556
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.444 0.556
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.444 0.556
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.444 0.556
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.444 0.556
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.444 0.556
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.444 0.556
E05.5 Thyroid crisis or storm
0.000 0.446 0.554
E05.4 Thyrotoxicosis factitia
0.000 0.446 0.554
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.446 0.554
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.446 0.554
E85.4 Organ-limited amyloidosis
0.000 0.452 0.548
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.454 0.546
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.454 0.546
E16.4 Abnormal secretion of gastrin
0.000 0.454 0.546
E16.3 Increased secretion of glucagon
0.000 0.454 0.546
I15.8 Other secondary hypertension
0.000 0.456 0.544
I15.2 Hypertension secondary to endocrine disorders
0.000 0.456 0.544
I15.0 Renovascular hypertension
0.000 0.456 0.544
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.459 0.541
E85.8 Other amyloidosis
0.000 0.461 0.538
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.461 0.538
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.461 0.538
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.461 0.538
E03.5 Myxoedema coma
0.000 0.461 0.538
E03.4 Atrophy of thyroid (acquired)
0.000 0.461 0.538
E03.3 Postinfectious hypothyroidism
0.000 0.461 0.538
E03.1 Congenital hypothyroidism without goitre
0.000 0.461 0.538
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.461 0.538
I15.9 Seconday hypertension, unspecified
0.000 0.467 0.533
E73 Lactose intolerance
0.000 0.468 0.532
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.471 0.529
E85.3 Secondary systemic amyloidosis
0.000 0.473 0.527
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.475 0.525
E07 Other disorders of thyroid
0.000 0.476 0.523
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.490 0.510
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.490 0.510
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.490 0.510
E74.2 Disorders of galactose metabolism
0.000 0.490 0.510
E74.1 Disorders of fructose metabolism
0.000 0.490 0.510
E74.0 Glycogen storage disease
0.000 0.490 0.510
G36.0 Neuromyelitis optica [Devic]
0.507 0.493 0.000
I24.1 Dressler's syndrome
0.000 0.493 0.506
G36.9 Acute disseminated demyelination, unspecified
0.504 0.496 0.000
G36.8 Other specified acute disseminated demyelination
0.504 0.496 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.504 0.496 0.000
I12.0 Hypertensive renal disease with renal failure
0.000 0.496 0.504
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.498 0.502
E89.3 Postprocedural hypopituitarism
0.000 0.498 0.502
E11.8 With unspecified complications
0.000 0.500 0.500
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.501 0.499
E06 Thyroiditis
0.000 0.503 0.497
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.507 0.493
E05.8 Other thyrotoxicosis
0.000 0.508 0.492
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.530 0.470
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.531 0.469
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.531 0.469
E79.1 Lesch-Nyhan syndrome
0.000 0.531 0.469
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.531 0.469
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.531 0.469
E70.3 Albinism
0.000 0.531 0.469
E70.2 Disorders of tyrosine metabolism
0.000 0.531 0.469
E70.1 Other hyperphenylalaninaemias
0.000 0.531 0.469
E70.0 Classical phenylketonuria
0.000 0.531 0.469
E71.3 Disorders of fatty-acid metabolism
0.000 0.531 0.469
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.531 0.469
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.531 0.469
E71.0 Maple-syrup-urine disease
0.000 0.531 0.469
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.531 0.469
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.531 0.469
E72.5 Disorders of glycine metabolism
0.000 0.531 0.469
E72.4 Disorders of ornithine metabolism
0.000 0.531 0.469
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.531 0.469
E72.2 Disorders of urea cycle metabolism
0.000 0.531 0.469
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.531 0.469
E72.0 Disorders of amino-acid transport
0.000 0.531 0.469
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.531 0.469
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.531 0.469
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.531 0.469
E76.2 Other mucopolysaccharidoses
0.000 0.531 0.469
E76.1 Mucopolysaccharidosis, type II
0.000 0.531 0.469
E76.0 Mucopolysaccharidosis, type I
0.000 0.531 0.469
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.531 0.469
E77.8 Other disorders of glycoprotein metabolism
0.000 0.531 0.469
E77.1 Defects in glycoprotein degradation
0.000 0.531 0.469
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.531 0.469
E83 Disorders of mineral metabolism
0.304 0.534 0.161
E75.6 Lipid storage disorder, unspecified
0.000 0.537 0.462
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.537 0.462
E75.3 Sphingolipidosis, unspecified
0.000 0.537 0.462
E75.2 Other sphingolipidosis
0.000 0.537 0.462
E75.1 Other gangliosidosis
0.000 0.537 0.462
E75.0 GM2 gangliosidosis
0.000 0.537 0.462
E88 Other metabolic disorders
0.000 0.538 0.462
E75.5 Other lipid storage disorders
0.000 0.546 0.453
L41.9 Parapsoriasis, unspecified
0.000 0.555 0.444
L41.8 Other parapsoriasis
0.000 0.555 0.444
L41.5 Retiform parapsoriasis
0.000 0.555 0.444
L41.4 Large plaque parapsoriasis
0.000 0.555 0.444
L41.3 Small plaque parapsoriasis
0.000 0.555 0.444
L41.2 Lymphomatoid papulosis
0.000 0.555 0.444
L41.1 Pityriasis lichenoides chronica
0.000 0.555 0.444
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.555 0.444
L44.9 Papulosquamous disorder, unspecified
0.000 0.555 0.444
L44.8 Other specified papulosquamous disorders
0.000 0.555 0.444
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.555 0.444
L44.3 Lichen ruber moniliformis
0.000 0.555 0.444
L44.2 Lichen striatus
0.000 0.555 0.444
L44.1 Lichen nitidus
0.000 0.555 0.444
L44.0 Pityriasis rubra pilaris
0.000 0.555 0.444
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.556 0.444
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.556 0.444
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.556 0.444
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.556 0.444
E65-E68 Obesity and other hyperalimentation
0.000 0.559 0.441
E84.8 Cystic fibrosis with other manifestations
0.000 0.570 0.429
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.570 0.429
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.570 0.429
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.573 0.427
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.582 0.418
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.582 0.418
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.582 0.418
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.582 0.418
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.582 0.418
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.582 0.418
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.582 0.418
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.582 0.418
E50-E64 Other nutritional deficiencies
0.000 0.586 0.414
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.586 0.414
E45 Retarded development following protein-energy malnutrition
0.000 0.586 0.414
E43 Unspecified severe protein-energy malnutrition
0.000 0.586 0.414
E42 Marasmic kwashiorkor
0.000 0.586 0.414
E41 Nutritional marasmus
0.000 0.586 0.414
E40 Kwashiorkor
0.000 0.586 0.414
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.589 0.411
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.589 0.411
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.589 0.411
E89.5 Postprocedural testicular hypofunction
0.000 0.589 0.411
E89.1 Postprocedural hypoinsulinaemia
0.000 0.589 0.411
I00-I02 Acute rheumatic fever
0.000 0.593 0.407
K90 Intestinal malabsorption
0.000 0.610 0.390
E89.4 Postprocedural ovarian failure
0.000 0.614 0.385
E73.8 Other lactose intolerance
0.000 0.618 0.381
E73.1 Secondary lactase deficiency
0.000 0.618 0.381
E73.0 Congenital lactase deficiency
0.000 0.618 0.381
E07.1 Dyshormogenetic goitre
0.000 0.624 0.375
E07.0 Hypersecretion of calcitonin
0.000 0.624 0.375
E84.9 Cystic fibrosis, unspecified
0.001 0.625 0.374
E07.8 Other specified disorders of thyroid
0.000 0.627 0.373
E80.6 Other disorders of bilirubin metabolism
0.000 0.630 0.370
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.632 0.368
E88.2 Lipomatosis, not elsewhere classified
0.000 0.632 0.367
E89.2 Postprocedural hypoparathyroidism
0.000 0.638 0.362
E06.5 Other chronic thyroiditis
0.000 0.643 0.357
E06.4 Drug-induced thyroiditis
0.000 0.643 0.357
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.643 0.357
E06.1 Subacute thyroiditis
0.000 0.643 0.357
E06.0 Acute thyroiditis
0.000 0.643 0.357
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.646 0.353
E80.5 Crigler-Najjar syndrome
0.000 0.646 0.353
E80.3 Defects of catalase and peroxydase
0.000 0.646 0.353
E80.2 Other porphyria
0.000 0.646 0.353
E80.1 Porphyria cutanea tarda
0.000 0.646 0.353
E80.0 Hereditary erythropoietic porphyria
0.000 0.646 0.353
E06.9 Thyroiditis, unspecified
0.000 0.662 0.338
E83.9 Disorder of mineral metabolism, unspecified
0.218 0.666 0.116
E83.8 Other disorders of mineral metabolism
0.218 0.666 0.116
E83.2 Disorders of zinc metabolism
0.218 0.666 0.116
E83.0 Disorders of copper metabolism
0.218 0.666 0.116
E88.8 Other specified metabolic disorders
0.000 0.667 0.333
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.668 0.332
E88.9 Metabolic disorder, unspecified
0.000 0.668 0.331
E46 Unspecified protein-energy malnutrition
0.000 0.670 0.330
E88.3 Tumour lysis syndrome
0.000 0.672 0.328
E07.9 Disorder of thyroid, unspecified
0.000 0.681 0.319
E03.8 Other specified hypothyroidism
0.001 0.682 0.318
E67 Other hyperalimentation
0.000 0.684 0.316
E68 Sequelae of hyperalimentation
0.000 0.684 0.316
E83.3 Disorders of phosphorus metabolism
0.255 0.689 0.055
E61 Deficiency of other nutrient elements
0.000 0.691 0.309
E65 Localised adiposity
0.000 0.693 0.307
E06.3 Autoimmune thyroiditis
0.000 0.703 0.297
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.703 0.297
E63 Other nutritional deficiencies
0.000 0.703 0.297
E56 Other vitamin deficiencies
0.000 0.703 0.297
E51 Thiamine deficiency
0.000 0.703 0.297
E50 Vitamin A deficiency
0.000 0.703 0.297
E60 Dietary zinc deficiency
0.000 0.703 0.297
E59 Dietary selenium deficiency
0.000 0.703 0.297
E58 Dietary calcium deficiency
0.000 0.703 0.297
E54 Ascorbic acid deficiency
0.000 0.703 0.297
E52 Niacin deficiency [pellagra]
0.000 0.703 0.297
E44.1 Mild protein-energy malnutrition
0.000 0.703 0.297
E44.0 Moderate protein-energy malnutrition
0.000 0.703 0.297
I02 Rheumatic chorea
0.000 0.708 0.292
I01 Rheumatic fever with heart involvement
0.000 0.708 0.292
I00 Rheumatic fever without mention of heart involvement
0.000 0.708 0.292
E20-E35 Disorders of other endocrine glands
0.000 0.713 0.287
K90.9 Intestinal malabsorption, unspecified
0.000 0.720 0.280
K90.3 Pancreatic steatorrhoea
0.000 0.720 0.280
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.720 0.280
K90.1 Tropical sprue
0.000 0.720 0.280
K90.8 Other intestinal malabsorption
0.000 0.720 0.280
E88.1 Lipodystrophy, not elsewhere classified
0.001 0.733 0.267
E73.9 Lactose intolerance, unspecified
0.001 0.740 0.259
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.749 0.251
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.755 0.245
E55 Vitamin D deficiency
0.000 0.757 0.243
E61.1 Iron deficiency
0.000 0.758 0.242
E23 Hypofunction and other disorders of pituitary gland
0.000 0.762 0.238
E22 Hyperfunction of pituitary gland
0.000 0.771 0.229
E67.8 Other specified hyperalimentation
0.000 0.773 0.227
E67.3 Hypervitaminosis D
0.000 0.773 0.227
E67.2 Megavitamin-B6 syndrome
0.000 0.773 0.227
E67.1 Hypercarotenaemia
0.000 0.773 0.227
E67.0 Hypervitaminosis A
0.000 0.773 0.227
E61.9 Deficiency of nutrient element, unspecified
0.000 0.778 0.222
E61.8 Deficiency of other specified nutrient elements
0.000 0.778 0.222
E61.7 Deficiency of multiple nutrient elements
0.000 0.778 0.222
E61.6 Vanadium deficiency
0.000 0.778 0.222
E61.5 Molybdenum deficiency
0.000 0.778 0.222
E61.4 Chromium deficiency
0.000 0.778 0.222
E61.3 Manganese deficiency
0.000 0.778 0.222
E61.0 Copper deficiency
0.000 0.778 0.222
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.001 0.782 0.217
E50.9 Vitamin A deficiency, unspecified
0.000 0.787 0.213
E50.8 Other manifestations of vitamin A deficiency
0.000 0.787 0.213
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.787 0.213
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.787 0.213
E50.5 Vitamin A deficiency with night blindness
0.000 0.787 0.213
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.787 0.213
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.787 0.213
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.787 0.213
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.787 0.213
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.787 0.213
E51.9 Thiamine deficiency, unspecified
0.000 0.787 0.213
E51.8 Other manifestations of thiamine deficiency
0.000 0.787 0.213
E51.2 Wernicke's encephalopathy
0.000 0.787 0.213
E51.1 Beriberi
0.000 0.787 0.213
E56.9 Vitamin deficiency, unspecified
0.000 0.787 0.213
E56.8 Deficiency of other vitamins
0.000 0.787 0.213
E56.1 Deficiency of vitamin K
0.000 0.787 0.213
E56.0 Deficiency of vitamin E
0.000 0.787 0.213
E63.9 Nutritional deficiency, unspecified
0.000 0.787 0.213
E63.8 Other specified nutritional deficiencies
0.000 0.787 0.213
E63.1 Imbalance of constituents of food intake
0.000 0.787 0.213
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.787 0.213
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.787 0.213
E64.8 Sequelae of other nutritional deficiencies
0.000 0.787 0.213
E64.3 Sequelae of rickets
0.000 0.787 0.213
E64.2 Sequelae of vitamin C deficiency
0.000 0.787 0.213
E64.1 Sequelae of vitamin A deficiency
0.000 0.787 0.213
E64.0 Sequelae of protein-energy malnutrition
0.000 0.787 0.213
E61.2 Magnesium deficiency
0.000 0.787 0.213
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.790 0.209
I01.8 Other acute rheumatic heart disease
0.000 0.790 0.209
I01.2 Acute rheumatic myocarditis
0.000 0.790 0.209
I01.1 Acute rheumatic endocarditis
0.000 0.790 0.209
I01.0 Acute rheumatic pericarditis
0.000 0.790 0.209
I02.9 Rheumatic chorea without heart involvement
0.000 0.790 0.209
I02.0 Rheumatic chorea with heart involvement
0.000 0.790 0.209
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.794 0.206
E32 Diseases of thymus
0.000 0.794 0.206
E31 Polyglandular dysfunction
0.000 0.794 0.206
E30 Disorders of puberty, not elsewhere classified
0.000 0.794 0.206
E25 Adrenogenital disorders
0.000 0.794 0.206
E83.4 Disorders of magnesium metabolism
0.089 0.797 0.114
E89.0 Postprocedural hypothyroidism
0.000 0.798 0.202
E26 Hyperaldosteronism
0.000 0.798 0.202
E23.6 Other disorders of pituitary gland
0.000 0.800 0.199
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.803 0.196
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.804 0.196
E23.2 Diabetes insipidus
0.000 0.805 0.195
E29 Testicular dysfunction
0.000 0.807 0.193
E24 Cushing's syndrome
0.000 0.808 0.192
E20 Hypoparathyroidism
0.000 0.815 0.184
E28 Ovarian dysfunction
0.000 0.817 0.183
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.818 0.182
E23.7 Disorder of pituitary gland, unspecified
0.000 0.819 0.180
E55.0 Rickets, active
0.000 0.825 0.174
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.829 0.170
E23.1 Drug-induced hypopituitarism
0.000 0.829 0.170
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.001 0.832 0.167
E22.1 Hyperprolactinaemia
0.000 0.835 0.165
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.835 0.164
E22.8 Other hyperfunction of pituitary gland
0.000 0.835 0.164
I20.8 Other forms of angina pectoris
0.000 0.840 0.160
E21.3 Hyperparathyroidism, unspecified
0.000 0.842 0.158
I28 Other diseases of pulmonary vessels
0.001 0.846 0.154
E80.4 Gilbert's syndrome
0.000 0.848 0.152
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.850 0.149
E22.0 Acromegaly and pituitary gigantism
0.000 0.851 0.149
E25.9 Adrenogenital disorder, unspecified
0.000 0.852 0.148
E25.8 Other adrenogenital disorders
0.000 0.852 0.148
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.852 0.148
E30.9 Disorder of puberty, unspecified
0.000 0.852 0.148
E30.8 Other disorders of puberty
0.000 0.852 0.148
E30.1 Precocious puberty
0.000 0.852 0.148
E30.0 Delayed puberty
0.000 0.852 0.148
E31.9 Polyglandular dysfunction, unspecified
0.000 0.852 0.148
E31.8 Other polyglandular dysfunction
0.000 0.852 0.148
E31.1 Polyglandular hyperfunction
0.000 0.852 0.148
E31.0 Autoimmune polyglandular failure
0.000 0.852 0.148
E32.9 Disease of thymus, unspecified
0.000 0.852 0.148
E32.8 Other diseases of thymus
0.000 0.852 0.148
E32.1 Abscess of thymus
0.000 0.852 0.148
E32.0 Persistent hyperplasia of thymus
0.000 0.852 0.148
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.852 0.148
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.852 0.148
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.852 0.148
E34 Other endocrine disorders
0.000 0.853 0.147
E26.9 Hyperaldosteronism, unspecified
0.000 0.855 0.145
E26.8 Other hyperaldosteronism
0.000 0.855 0.145
E26.1 Secondary hyperaldosteronism
0.000 0.855 0.145
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.859 0.141
E21.4 Other specified disorders of parathyroid gland
0.000 0.859 0.141
E21.2 Other hyperparathyroidism
0.000 0.859 0.141
E26.0 Primary hyperaldosteronism
0.000 0.859 0.140
E29.9 Testicular dysfunction, unspecified
0.000 0.862 0.138
E29.8 Other testicular dysfunction
0.000 0.862 0.138
E29.0 Testicular hyperfunction
0.000 0.862 0.138
E24.8 Other Cushing's syndrome
0.000 0.862 0.138
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.862 0.138
E24.3 Ectopic ACTH syndrome
0.000 0.862 0.138
E24.2 Drug-induced Cushing's syndrome
0.000 0.862 0.138
E24.1 Nelson's syndrome
0.000 0.862 0.138
E24.0 Pituitary-dependent Cushing's disease
0.000 0.862 0.138
E53 Deficiency of other B group vitamins
0.001 0.864 0.135
E20.8 Other hypoparathyroidism
0.000 0.867 0.132

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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