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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3093981
log Bayes Factor = 62.784
Chromosome 6   position 31,497,457  (GRCh37) Explore rs3093981 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.001 0.999
E78.0 Pure hypercholesterolaemia
0.000 0.002 0.998
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.006 0.994
E14.9 Without complications
0.000 0.010 0.990
I20 Angina pectoris
0.000 0.010 0.990
I25.5 Ischaemic cardiomyopathy
0.000 0.013 0.987
E10.1 With ketoacidosis
0.000 0.013 0.987
E14.3 With ophthalmic complications
0.000 0.014 0.986
E10.4 With neurological complications
0.000 0.019 0.981
I22 Subsequent myocardial infarction
0.000 0.021 0.979
I20.9 Angina pectoris, unspecified
0.000 0.024 0.976
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.025 0.975
G35-G37 Demyelinating diseases of the central nervous system
0.970 0.030 0.000
G37 Other demyelinating diseases of central nervous system
0.964 0.036 0.000
E83.1 Disorders of iron metabolism
0.957 0.043 0.000
I20.0 Unstable angina
0.000 0.045 0.955
I25.2 Old myocardial infarction
0.000 0.046 0.954
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.050 0.950
G37.9 Demyelinating disease of central nervous system, unspecified
0.949 0.051 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.052 0.948
E70-E90 Metabolic disorders
0.000 0.060 0.940
I21 Acute myocardial infarction
0.000 0.071 0.929
E13 Other specified diabetes mellitus
0.000 0.076 0.924
I10 Essential (primary) hypertension
0.000 0.095 0.905
E78.8 Other disorders of lipoprotein metabolism
0.000 0.111 0.889
L40-L45 Papulosquamous disorders
0.000 0.112 0.888
E10.2 With renal complications
0.000 0.119 0.881
I21.9 Acute myocardial infarction, unspecified
0.000 0.120 0.880
I24 Other acute ischaemic heart diseases
0.000 0.122 0.878
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.128 0.872
E11.2 With renal complications
0.000 0.128 0.872
E00-E07 Disorders of thyroid gland
0.000 0.130 0.870
E13.9 Without complications
0.000 0.131 0.869
L43 Lichen planus
0.000 0.139 0.861
E11.0 With coma
0.000 0.143 0.857
G37.8 Other specified demyelinating diseases of central nervous system
0.847 0.153 0.000
I25.3 Aneurysm of heart
0.000 0.156 0.844
L40.8 Other psoriasis
0.000 0.159 0.841
E03 Other hypothyroidism
0.000 0.170 0.830
I10-I15 Hypertensive diseases
0.000 0.170 0.830
L43.9 Lichen planus, unspecified
0.000 0.170 0.830
E11.1 With ketoacidosis
0.000 0.175 0.825
E14.4 With neurological complications
0.000 0.177 0.823
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.178 0.822
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.179 0.821
E03.9 Hypothyroidism, unspecified
0.000 0.182 0.818
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.187 0.813
R07.4 Chest pain, unspecified
0.000 0.188 0.812
E10.8 With unspecified complications
0.000 0.190 0.810
E10.5 With peripheral circulatory complications
0.000 0.204 0.795
I21.4 Acute subendocardial myocardial infarction
0.000 0.206 0.794
E05.9 Thyrotoxicosis, unspecified
0.000 0.206 0.794
E10.0 With coma
0.000 0.207 0.793
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.790 0.210 0.000
E78.2 Mixed hyperlipidaemia
0.000 0.211 0.789
E11.6 With other specified complications
0.000 0.217 0.783
L40.0 Psoriasis vulgaris
0.000 0.224 0.776
I23 Certain current complications following acute myocardial infarction
0.000 0.225 0.775
E85 Amyloidosis
0.000 0.227 0.773
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.230 0.770
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.248 0.752
E78.6 Lipoprotein deficiency
0.000 0.260 0.740
E10.6 With other specified complications
0.000 0.267 0.733
E74 Other disorders of carbohydrate metabolism
0.000 0.268 0.732
E16 Other disorders of pancreatic internal secretion
0.000 0.271 0.729
I15 Secondary hypertension
0.000 0.271 0.729
I24.8 Other forms of acute ischaemic heart disease
0.000 0.274 0.726
E14.6 With other specified complications
0.000 0.279 0.721
E10.7 With multiple complications
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.5 With peripheral circulatory complications
0.000 0.283 0.717
E14.2 Withrenal complications
0.000 0.283 0.717
E14.1 With ketoacidosis
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
L43.8 Other lichen planus
0.000 0.289 0.711
E78.1 Pure hyperglyceridaemia
0.000 0.291 0.709
E11.5 With peripheral circulatory complications
0.000 0.293 0.707
G36 Other acute disseminated demyelination
0.699 0.300 0.000
E78.3 Hyperchylomicronaemia
0.000 0.301 0.699
L40.3 Pustulosis palmaris et plantaris
0.000 0.306 0.694
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.307 0.693
G37.5 Concentric sclerosis [Balo]
0.691 0.308 0.000
G37.4 Subacute necrotising myelitis
0.691 0.308 0.000
G37.2 Central pontine myelinolysis
0.691 0.308 0.000
G37.1 Central demyelination of corpus callosum
0.691 0.308 0.000
G37.0 Diffuse sclerosis
0.691 0.308 0.000
I12 Hypertensive renal disease
0.000 0.318 0.682
E79 Disorders of purine and pyrimidine metabolism
0.000 0.325 0.674
E77 Disorders of glycoprotein metabolism
0.000 0.326 0.674
E76 Disorders of glycosaminoglycan metabolism
0.000 0.326 0.674
E72 Other disorders of amino-acid metabolism
0.000 0.326 0.674
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.326 0.674
E70 Disorders of aromatic amino-acid metabolism
0.000 0.326 0.674
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.326 0.674
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.328 0.672
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.334 0.666
E78.5 Hyperlipidaemia, unspecified
0.000 0.334 0.666
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.335 0.665
E13.8 With unspecified complications
0.000 0.338 0.662
E13.7 With multiple complications
0.000 0.338 0.662
E13.6 With other specified complications
0.000 0.338 0.662
E13.5 With peripheral circulatory complications
0.000 0.338 0.662
E13.4 With neurological complications
0.000 0.338 0.662
E13.3 With ophthalmic complications
0.000 0.338 0.662
E13.2 With renal complications
0.000 0.338 0.662
E13.1 With ketoacidosis
0.000 0.338 0.662
E13.0 With coma
0.000 0.338 0.662
E78.4 Other hyperlipidaemia
0.000 0.339 0.661
I15.1 Hypertension secondary to other renal disorders
0.000 0.340 0.660
I22.8 Subsequent myocardial infarction of other sites
0.000 0.344 0.655
E85.9 Amyloidosis, unspecified
0.000 0.345 0.654
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.347 0.653
I11 Hypertensive heart disease
0.000 0.349 0.651
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.352 0.648
E16.2 Hypoglycaemia, unspecified
0.000 0.356 0.644
L42 Pityriasis rosea
0.000 0.356 0.644
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.362 0.638
L44 Other papulosquamous disorders
0.000 0.363 0.637
L41 Parapsoriasis
0.000 0.363 0.637
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.363 0.637
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.376 0.623
E00 Congenital iodine-deficiency syndrome
0.000 0.376 0.623
E11.4 With neurological complications
0.000 0.381 0.619
L43.3 Subacute (active) lichen planus
0.000 0.382 0.617
L43.2 Lichenoid drug reaction
0.000 0.382 0.617
L43.1 Bullous lichen planus
0.000 0.382 0.617
L43.0 Hypertrophic lichen planus
0.000 0.382 0.617
E84 Cystic fibrosis
0.000 0.383 0.617
I23.8 Other current complications following acute myocardial infarction
0.000 0.387 0.613
I20.1 Angina pectoris with documented spasm
0.000 0.392 0.608
I12.9 Hypertensive renal disease without renal failure
0.000 0.397 0.603
E40-E46 Malnutrition
0.000 0.401 0.599
E03.5 Myxoedema coma
0.000 0.405 0.595
E03.4 Atrophy of thyroid (acquired)
0.000 0.405 0.595
E03.3 Postinfectious hypothyroidism
0.000 0.405 0.595
E03.1 Congenital hypothyroidism without goitre
0.000 0.405 0.595
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.405 0.595
I13 Hypertensive heart and renal disease
0.000 0.405 0.595
E05.5 Thyroid crisis or storm
0.000 0.410 0.590
E05.4 Thyrotoxicosis factitia
0.000 0.410 0.590
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.410 0.590
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.410 0.590
E15 Nondiabetic hypoglycaemic coma
0.000 0.412 0.588
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.415 0.584
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.417 0.583
I25.4 Coronary artery aneurysm
0.000 0.420 0.580
E16.1 Other hypoglycaemia
0.000 0.427 0.573
E89.3 Postprocedural hypopituitarism
0.000 0.428 0.572
Chapter IX Diseases of the circulatory system
0.000 0.428 0.572
E85.4 Organ-limited amyloidosis
0.000 0.436 0.564
E07 Other disorders of thyroid
0.000 0.442 0.557
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.444 0.555
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.444 0.555
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.444 0.555
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.444 0.555
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.444 0.555
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.444 0.555
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.444 0.555
E85.8 Other amyloidosis
0.000 0.446 0.554
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.446 0.554
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.446 0.554
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.446 0.554
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.447 0.553
E73 Lactose intolerance
0.000 0.452 0.548
E85.3 Secondary systemic amyloidosis
0.000 0.458 0.542
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.463 0.537
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.470 0.530
E06 Thyroiditis
0.000 0.470 0.530
E11.3 With ophthalmic complications
0.000 0.473 0.527
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.475 0.525
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.475 0.525
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.475 0.525
E74.2 Disorders of galactose metabolism
0.000 0.475 0.525
E74.1 Disorders of fructose metabolism
0.000 0.475 0.525
E74.0 Glycogen storage disease
0.000 0.475 0.525
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.477 0.523
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.477 0.523
E16.4 Abnormal secretion of gastrin
0.000 0.477 0.523
E16.3 Increased secretion of glucagon
0.000 0.477 0.523
I15.8 Other secondary hypertension
0.000 0.477 0.523
I15.2 Hypertension secondary to endocrine disorders
0.000 0.477 0.523
I15.0 Renovascular hypertension
0.000 0.477 0.523
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.478 0.522
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.482 0.518
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
I15.9 Seconday hypertension, unspecified
0.000 0.488 0.512
G36.0 Neuromyelitis optica [Devic]
0.505 0.495 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.497 0.503
G36.9 Acute disseminated demyelination, unspecified
0.501 0.498 0.000
G36.8 Other specified acute disseminated demyelination
0.501 0.498 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.501 0.498 0.000
I24.1 Dressler's syndrome
0.000 0.500 0.500
E11.8 With unspecified complications
0.000 0.500 0.499
E83 Disorders of mineral metabolism
0.358 0.504 0.137
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.516 0.484
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.516 0.483
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.516 0.483
E79.1 Lesch-Nyhan syndrome
0.000 0.516 0.483
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.516 0.483
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.516 0.483
E70.3 Albinism
0.000 0.516 0.483
E70.2 Disorders of tyrosine metabolism
0.000 0.516 0.483
E70.1 Other hyperphenylalaninaemias
0.000 0.516 0.483
E70.0 Classical phenylketonuria
0.000 0.516 0.483
E71.3 Disorders of fatty-acid metabolism
0.000 0.516 0.483
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.516 0.483
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.516 0.483
E71.0 Maple-syrup-urine disease
0.000 0.516 0.483
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.516 0.483
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.516 0.483
E72.5 Disorders of glycine metabolism
0.000 0.516 0.483
E72.4 Disorders of ornithine metabolism
0.000 0.516 0.483
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.516 0.483
E72.2 Disorders of urea cycle metabolism
0.000 0.516 0.483
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.516 0.483
E72.0 Disorders of amino-acid transport
0.000 0.516 0.483
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.516 0.483
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.516 0.483
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.516 0.483
E76.2 Other mucopolysaccharidoses
0.000 0.516 0.483
E76.1 Mucopolysaccharidosis, type II
0.000 0.516 0.483
E76.0 Mucopolysaccharidosis, type I
0.000 0.516 0.483
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.516 0.483
E77.8 Other disorders of glycoprotein metabolism
0.000 0.516 0.483
E77.1 Defects in glycoprotein degradation
0.000 0.516 0.483
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.516 0.483
E05.8 Other thyrotoxicosis
0.000 0.517 0.482
E75.6 Lipid storage disorder, unspecified
0.000 0.523 0.477
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.523 0.477
E75.3 Sphingolipidosis, unspecified
0.000 0.523 0.477
E75.2 Other sphingolipidosis
0.000 0.523 0.477
E75.1 Other gangliosidosis
0.000 0.523 0.477
E75.0 GM2 gangliosidosis
0.000 0.523 0.477
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.531 0.468
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.531 0.468
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.531 0.468
E89.5 Postprocedural testicular hypofunction
0.000 0.531 0.468
E89.1 Postprocedural hypoinsulinaemia
0.000 0.531 0.468
E75.5 Other lipid storage disorders
0.000 0.532 0.467
E88 Other metabolic disorders
0.000 0.535 0.464
E65-E68 Obesity and other hyperalimentation
0.000 0.542 0.458
L41.9 Parapsoriasis, unspecified
0.000 0.543 0.457
L41.8 Other parapsoriasis
0.000 0.543 0.457
L41.5 Retiform parapsoriasis
0.000 0.543 0.457
L41.4 Large plaque parapsoriasis
0.000 0.543 0.457
L41.3 Small plaque parapsoriasis
0.000 0.543 0.457
L41.2 Lymphomatoid papulosis
0.000 0.543 0.457
L41.1 Pityriasis lichenoides chronica
0.000 0.543 0.457
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.543 0.457
L44.9 Papulosquamous disorder, unspecified
0.000 0.543 0.457
L44.8 Other specified papulosquamous disorders
0.000 0.543 0.457
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.543 0.457
L44.3 Lichen ruber moniliformis
0.000 0.543 0.457
L44.2 Lichen striatus
0.000 0.543 0.457
L44.1 Lichen nitidus
0.000 0.543 0.457
L44.0 Pityriasis rubra pilaris
0.000 0.543 0.457
K90 Intestinal malabsorption
0.000 0.549 0.451
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.553 0.447
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.553 0.447
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.553 0.447
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.553 0.447
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.553 0.447
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.553 0.447
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.553 0.447
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.553 0.447
E50-E64 Other nutritional deficiencies
0.000 0.555 0.445
E84.8 Cystic fibrosis with other manifestations
0.000 0.557 0.442
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.557 0.442
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.557 0.442
E89.4 Postprocedural ovarian failure
0.000 0.560 0.440
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.571 0.429
E45 Retarded development following protein-energy malnutrition
0.000 0.571 0.429
E43 Unspecified severe protein-energy malnutrition
0.000 0.571 0.429
E42 Marasmic kwashiorkor
0.000 0.571 0.429
E41 Nutritional marasmus
0.000 0.571 0.429
E40 Kwashiorkor
0.000 0.571 0.429
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.573 0.427
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.573 0.427
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.573 0.427
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.573 0.427
I12.0 Hypertensive renal disease with renal failure
0.000 0.577 0.423
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.586 0.414
E89.2 Postprocedural hypoparathyroidism
0.000 0.588 0.412
I00-I02 Acute rheumatic fever
0.000 0.590 0.410
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.591 0.409
E07.1 Dyshormogenetic goitre
0.000 0.600 0.400
E07.0 Hypersecretion of calcitonin
0.000 0.600 0.400
E07.8 Other specified disorders of thyroid
0.000 0.603 0.397
E73.8 Other lactose intolerance
0.000 0.607 0.393
E73.1 Secondary lactase deficiency
0.000 0.607 0.393
E73.0 Congenital lactase deficiency
0.000 0.607 0.393
E84.9 Cystic fibrosis, unspecified
0.001 0.614 0.385
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.615 0.384
E06.5 Other chronic thyroiditis
0.000 0.620 0.380
E06.4 Drug-induced thyroiditis
0.000 0.620 0.380
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.620 0.380
E06.1 Subacute thyroiditis
0.000 0.620 0.380
E06.0 Acute thyroiditis
0.000 0.620 0.380
E80.6 Other disorders of bilirubin metabolism
0.000 0.622 0.377
E88.2 Lipomatosis, not elsewhere classified
0.000 0.630 0.369
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.639 0.361
E80.5 Crigler-Najjar syndrome
0.000 0.639 0.361
E80.3 Defects of catalase and peroxydase
0.000 0.639 0.361
E80.2 Other porphyria
0.000 0.639 0.361
E80.1 Porphyria cutanea tarda
0.000 0.639 0.361
E80.0 Hereditary erythropoietic porphyria
0.000 0.639 0.361
E06.9 Thyroiditis, unspecified
0.000 0.640 0.360
E83.9 Disorder of mineral metabolism, unspecified
0.257 0.644 0.099
E83.8 Other disorders of mineral metabolism
0.257 0.644 0.099
E83.2 Disorders of zinc metabolism
0.257 0.644 0.099
E83.0 Disorders of copper metabolism
0.257 0.644 0.099
E03.8 Other specified hypothyroidism
0.001 0.649 0.351
E46 Unspecified protein-energy malnutrition
0.000 0.652 0.348
E83.3 Disorders of phosphorus metabolism
0.301 0.652 0.047
E89.0 Postprocedural hypothyroidism
0.000 0.657 0.343
E61 Deficiency of other nutrient elements
0.000 0.658 0.342
E07.9 Disorder of thyroid, unspecified
0.000 0.663 0.337
E88.8 Other specified metabolic disorders
0.000 0.665 0.334
E88.9 Metabolic disorder, unspecified
0.000 0.667 0.333
E20-E35 Disorders of other endocrine glands
0.000 0.667 0.332
E88.3 Tumour lysis syndrome
0.000 0.670 0.329
E67 Other hyperalimentation
0.000 0.671 0.329
E68 Sequelae of hyperalimentation
0.000 0.671 0.329
K90.3 Pancreatic steatorrhoea
0.000 0.677 0.323
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.677 0.323
K90.1 Tropical sprue
0.000 0.677 0.323
K90.8 Other intestinal malabsorption
0.000 0.677 0.323
K90.9 Intestinal malabsorption, unspecified
0.000 0.677 0.323
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.681 0.319
E63 Other nutritional deficiencies
0.000 0.681 0.319
E56 Other vitamin deficiencies
0.000 0.681 0.319
E51 Thiamine deficiency
0.000 0.681 0.319
E50 Vitamin A deficiency
0.000 0.681 0.319
E60 Dietary zinc deficiency
0.000 0.681 0.319
E59 Dietary selenium deficiency
0.000 0.681 0.319
E58 Dietary calcium deficiency
0.000 0.681 0.319
E54 Ascorbic acid deficiency
0.000 0.681 0.319
E52 Niacin deficiency [pellagra]
0.000 0.681 0.319
E65 Localised adiposity
0.000 0.681 0.319
E06.3 Autoimmune thyroiditis
0.000 0.685 0.315
E44.1 Mild protein-energy malnutrition
0.000 0.692 0.308
E44.0 Moderate protein-energy malnutrition
0.000 0.692 0.308
I02 Rheumatic chorea
0.000 0.706 0.294
I01 Rheumatic fever with heart involvement
0.000 0.706 0.294
I00 Rheumatic fever without mention of heart involvement
0.000 0.706 0.294
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.711 0.289
E23 Hypofunction and other disorders of pituitary gland
0.000 0.718 0.282
E61.1 Iron deficiency
0.000 0.729 0.271
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.731 0.269
E88.1 Lipodystrophy, not elsewhere classified
0.001 0.731 0.268
E73.9 Lactose intolerance, unspecified
0.001 0.733 0.266
E22 Hyperfunction of pituitary gland
0.000 0.735 0.265
E55 Vitamin D deficiency
0.000 0.740 0.260
E61.9 Deficiency of nutrient element, unspecified
0.000 0.755 0.245
E61.8 Deficiency of other specified nutrient elements
0.000 0.755 0.245
E61.7 Deficiency of multiple nutrient elements
0.000 0.755 0.245
E61.6 Vanadium deficiency
0.000 0.755 0.245
E61.5 Molybdenum deficiency
0.000 0.755 0.245
E61.4 Chromium deficiency
0.000 0.755 0.245
E61.3 Manganese deficiency
0.000 0.755 0.245
E61.0 Copper deficiency
0.000 0.755 0.245
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.756 0.244
E61.2 Magnesium deficiency
0.000 0.759 0.241
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.761 0.238
E32 Diseases of thymus
0.000 0.761 0.238
E31 Polyglandular dysfunction
0.000 0.761 0.238
E30 Disorders of puberty, not elsewhere classified
0.000 0.761 0.238
E25 Adrenogenital disorders
0.000 0.761 0.238
E23.2 Diabetes insipidus
0.000 0.763 0.237
E23.6 Other disorders of pituitary gland
0.000 0.763 0.237
E67.8 Other specified hyperalimentation
0.000 0.764 0.236
E67.3 Hypervitaminosis D
0.000 0.764 0.236
E67.2 Megavitamin-B6 syndrome
0.000 0.764 0.236
E67.1 Hypercarotenaemia
0.000 0.764 0.236
E67.0 Hypervitaminosis A
0.000 0.764 0.236
E26 Hyperaldosteronism
0.000 0.766 0.233
E50.9 Vitamin A deficiency, unspecified
0.000 0.771 0.229
E50.8 Other manifestations of vitamin A deficiency
0.000 0.771 0.229
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.771 0.229
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.771 0.229
E50.5 Vitamin A deficiency with night blindness
0.000 0.771 0.229
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.771 0.229
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.771 0.229
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.771 0.229
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.771 0.229
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.771 0.229
E51.9 Thiamine deficiency, unspecified
0.000 0.771 0.229
E51.8 Other manifestations of thiamine deficiency
0.000 0.771 0.229
E51.2 Wernicke's encephalopathy
0.000 0.771 0.229
E51.1 Beriberi
0.000 0.771 0.229
E56.9 Vitamin deficiency, unspecified
0.000 0.771 0.229
E56.8 Deficiency of other vitamins
0.000 0.771 0.229
E56.1 Deficiency of vitamin K
0.000 0.771 0.229
E56.0 Deficiency of vitamin E
0.000 0.771 0.229
E63.9 Nutritional deficiency, unspecified
0.000 0.771 0.229
E63.8 Other specified nutritional deficiencies
0.000 0.771 0.229
E63.1 Imbalance of constituents of food intake
0.000 0.771 0.229
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.771 0.229
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.771 0.229
E64.8 Sequelae of other nutritional deficiencies
0.000 0.771 0.229
E64.3 Sequelae of rickets
0.000 0.771 0.229
E64.2 Sequelae of vitamin C deficiency
0.000 0.771 0.229
E64.1 Sequelae of vitamin A deficiency
0.000 0.771 0.229
E64.0 Sequelae of protein-energy malnutrition
0.000 0.771 0.229
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.772 0.228
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.774 0.226
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.002 0.775 0.223
E29 Testicular dysfunction
0.000 0.777 0.223
E24 Cushing's syndrome
0.000 0.778 0.222
E23.7 Disorder of pituitary gland, unspecified
0.000 0.786 0.214
E20 Hypoparathyroidism
0.000 0.786 0.213
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.789 0.211
I01.8 Other acute rheumatic heart disease
0.000 0.789 0.211
I01.2 Acute rheumatic myocarditis
0.000 0.789 0.211
I01.1 Acute rheumatic endocarditis
0.000 0.789 0.211
I01.0 Acute rheumatic pericarditis
0.000 0.789 0.211
I02.9 Rheumatic chorea without heart involvement
0.000 0.789 0.211
I02.0 Rheumatic chorea with heart involvement
0.000 0.789 0.211
E83.4 Disorders of magnesium metabolism
0.115 0.794 0.091
E21.3 Hyperparathyroidism, unspecified
0.000 0.797 0.203
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.798 0.202
E23.1 Drug-induced hypopituitarism
0.000 0.798 0.202
M45 Ankylosing spondylitis
0.000 0.798 0.202
E28 Ovarian dysfunction
0.000 0.800 0.200
E22.1 Hyperprolactinaemia
0.000 0.810 0.190
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.810 0.190
E22.8 Other hyperfunction of pituitary gland
0.000 0.810 0.190
E55.0 Rickets, active
0.000 0.813 0.187
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.814 0.186
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.819 0.181
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.825 0.175
E21.4 Other specified disorders of parathyroid gland
0.000 0.825 0.175
E21.2 Other hyperparathyroidism
0.000 0.825 0.175
E34 Other endocrine disorders
0.000 0.828 0.171
E22.0 Acromegaly and pituitary gigantism
0.000 0.828 0.171
E25.9 Adrenogenital disorder, unspecified
0.000 0.829 0.171
E25.8 Other adrenogenital disorders
0.000 0.829 0.171
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.829 0.171
E30.9 Disorder of puberty, unspecified
0.000 0.829 0.171
E30.8 Other disorders of puberty
0.000 0.829 0.171
E30.1 Precocious puberty
0.000 0.829 0.171
E30.0 Delayed puberty
0.000 0.829 0.171
E31.9 Polyglandular dysfunction, unspecified
0.000 0.829 0.171
E31.8 Other polyglandular dysfunction
0.000 0.829 0.171
E31.1 Polyglandular hyperfunction
0.000 0.829 0.171
E31.0 Autoimmune polyglandular failure
0.000 0.829 0.171
E32.9 Disease of thymus, unspecified
0.000 0.829 0.171
E32.8 Other diseases of thymus
0.000 0.829 0.171
E32.1 Abscess of thymus
0.000 0.829 0.171
E32.0 Persistent hyperplasia of thymus
0.000 0.829 0.171
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.829 0.171
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.829 0.171
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.829 0.171
E26.9 Hyperaldosteronism, unspecified
0.000 0.832 0.167
E26.8 Other hyperaldosteronism
0.000 0.832 0.167
E26.1 Secondary hyperaldosteronism
0.000 0.832 0.167
M75.0 Adhesive capsulitis of shoulder
0.000 0.835 0.165
E26.0 Primary hyperaldosteronism
0.000 0.837 0.162
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.837 0.163
H66.3 Other chronic suppurative otitis media
0.000 0.838 0.162
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.839 0.161
E29.9 Testicular dysfunction, unspecified
0.000 0.840 0.160
E29.8 Other testicular dysfunction
0.000 0.840 0.160
E29.0 Testicular hyperfunction
0.000 0.840 0.160
E24.8 Other Cushing's syndrome
0.000 0.840 0.159
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.840 0.159
E24.3 Ectopic ACTH syndrome
0.000 0.840 0.159
E24.2 Drug-induced Cushing's syndrome
0.000 0.840 0.159
E24.1 Nelson's syndrome
0.000 0.840 0.159
E24.0 Pituitary-dependent Cushing's disease
0.000 0.840 0.159

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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