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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3093992
log Bayes Factor = 47.5428
Chromosome 6   position 31,491,131  (GRCh37) Explore rs3093992 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.002 0.998
E05.9 Thyrotoxicosis, unspecified
0.000 0.002 0.998
E00-E07 Disorders of thyroid gland
0.000 0.003 0.997
E11 Non-insulin-dependent diabetes mellitus
0.000 0.006 0.994
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.007 0.993
E11.9 Without complications
0.000 0.008 0.992
E14.3 With ophthalmic complications
0.000 0.012 0.988
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.013 0.987
E10.1 With ketoacidosis
0.000 0.019 0.981
E03 Other hypothyroidism
0.000 0.025 0.975
E10.4 With neurological complications
0.000 0.027 0.973
E03.9 Hypothyroidism, unspecified
0.000 0.029 0.971
E14.9 Without complications
0.000 0.029 0.971
E10.2 With renal complications
0.000 0.071 0.929
E11.0 With coma
0.000 0.079 0.921
J45.9 Asthma, unspecified
0.000 0.129 0.871
E14.8 With unspecified complications
0.000 0.155 0.845
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.156 0.844
E10.8 With unspecified complications
0.000 0.192 0.808
G35-G37 Demyelinating diseases of the central nervous system
0.807 0.193 0.000
E13 Other specified diabetes mellitus
0.000 0.195 0.805
E10.0 With coma
0.000 0.204 0.796
E11.5 With peripheral circulatory complications
0.000 0.221 0.779
E07 Other disorders of thyroid
0.000 0.221 0.779
E10.5 With peripheral circulatory complications
0.000 0.226 0.774
G37 Other demyelinating diseases of central nervous system
0.768 0.232 0.000
E14.6 With other specified complications
0.000 0.248 0.752
E14.5 With peripheral circulatory complications
0.000 0.255 0.745
E06 Thyroiditis
0.000 0.255 0.745
E14.4 With neurological complications
0.000 0.259 0.741
E16 Other disorders of pancreatic internal secretion
0.000 0.263 0.737
E83.1 Disorders of iron metabolism
0.736 0.264 0.000
E14.1 With ketoacidosis
0.000 0.277 0.723
G37.9 Demyelinating disease of central nervous system, unspecified
0.723 0.277 0.000
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.716
E14.2 Withrenal complications
0.000 0.283 0.716
E14.0 With coma
0.000 0.283 0.716
E05.5 Thyroid crisis or storm
0.000 0.284 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.284 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.284 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.284 0.716
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.285 0.715
E00 Congenital iodine-deficiency syndrome
0.000 0.285 0.715
E11.7 With multiple complications
0.000 0.287 0.713
E11.2 With renal complications
0.000 0.295 0.705
E03.5 Myxoedema coma
0.000 0.301 0.699
E03.4 Atrophy of thyroid (acquired)
0.000 0.301 0.699
E03.3 Postinfectious hypothyroidism
0.000 0.301 0.699
E10.6 With other specified complications
0.000 0.306 0.694
E11.1 With ketoacidosis
0.000 0.312 0.688
E03.1 Congenital hypothyroidism without goitre
0.000 0.315 0.685
E13.9 Without complications
0.000 0.323 0.677
E11.6 With other specified complications
0.000 0.331 0.669
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.334 0.666
E05.8 Other thyrotoxicosis
0.000 0.339 0.661
E07.9 Disorder of thyroid, unspecified
0.000 0.354 0.646
K90 Intestinal malabsorption
0.000 0.354 0.646
G37.8 Other specified demyelinating diseases of central nervous system
0.645 0.355 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.359 0.641
E16.2 Hypoglycaemia, unspecified
0.000 0.362 0.638
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.363 0.637
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.371 0.629
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.373 0.626
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.386 0.614
E65-E68 Obesity and other hyperalimentation
0.000 0.386 0.614
E06.9 Thyroiditis, unspecified
0.000 0.393 0.607
E15 Nondiabetic hypoglycaemic coma
0.000 0.395 0.605
K90.9 Intestinal malabsorption, unspecified
0.000 0.406 0.594
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.413 0.587
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.414 0.586
G36 Other acute disseminated demyelination
0.580 0.419 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.420 0.580
E11.8 With unspecified complications
0.000 0.423 0.577
E13.8 With unspecified complications
0.000 0.423 0.577
E13.7 With multiple complications
0.000 0.423 0.577
E13.6 With other specified complications
0.000 0.423 0.577
E13.5 With peripheral circulatory complications
0.000 0.423 0.577
E13.4 With neurological complications
0.000 0.423 0.577
E13.2 With renal complications
0.000 0.423 0.577
E13.1 With ketoacidosis
0.000 0.423 0.577
E13.0 With coma
0.000 0.423 0.577
E16.1 Other hypoglycaemia
0.000 0.427 0.572
E40-E46 Malnutrition
0.000 0.432 0.568
E07.1 Dyshormogenetic goitre
0.000 0.441 0.559
E07.0 Hypersecretion of calcitonin
0.000 0.441 0.559
E13.3 With ophthalmic complications
0.000 0.445 0.555
M45 Ankylosing spondylitis
0.000 0.447 0.553
G37.5 Concentric sclerosis [Balo]
0.551 0.449 0.000
G37.4 Subacute necrotising myelitis
0.551 0.449 0.000
G37.2 Central pontine myelinolysis
0.551 0.449 0.000
G37.1 Central demyelination of corpus callosum
0.551 0.449 0.000
G37.0 Diffuse sclerosis
0.551 0.449 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.456 0.544
E06.5 Other chronic thyroiditis
0.000 0.466 0.534
E06.4 Drug-induced thyroiditis
0.000 0.466 0.534
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.466 0.534
E06.1 Subacute thyroiditis
0.000 0.466 0.534
E06.0 Acute thyroiditis
0.000 0.466 0.534
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.468 0.532
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.471 0.528
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.471 0.528
E16.4 Abnormal secretion of gastrin
0.000 0.471 0.528
E16.3 Increased secretion of glucagon
0.000 0.471 0.528
E11.4 With neurological complications
0.000 0.473 0.527
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.527 0.473 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.477 0.523
E07.8 Other specified disorders of thyroid
0.000 0.480 0.519
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.487 0.513
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.487 0.513
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.487 0.513
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.487 0.513
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.487 0.513
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.487 0.513
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.487 0.513
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.487 0.513
E65 Localised adiposity
0.000 0.491 0.509
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.495 0.505
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.508 0.492
K90.8 Other intestinal malabsorption
0.000 0.525 0.475
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.528 0.472
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.530 0.470
E06.3 Autoimmune thyroiditis
0.000 0.531 0.469
K90.3 Pancreatic steatorrhoea
0.000 0.537 0.463
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.537 0.463
K90.1 Tropical sprue
0.000 0.537 0.463
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.546 0.454
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.549 0.451
E67 Other hyperalimentation
0.000 0.560 0.440
E68 Sequelae of hyperalimentation
0.000 0.560 0.440
G36.0 Neuromyelitis optica [Devic]
0.418 0.582 0.000
G36.9 Acute disseminated demyelination, unspecified
0.416 0.584 0.000
G36.8 Other specified acute disseminated demyelination
0.416 0.584 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.416 0.584 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.590 0.409
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.593 0.407
E45 Retarded development following protein-energy malnutrition
0.000 0.593 0.407
E43 Unspecified severe protein-energy malnutrition
0.000 0.593 0.407
E42 Marasmic kwashiorkor
0.000 0.593 0.407
E41 Nutritional marasmus
0.000 0.593 0.407
E40 Kwashiorkor
0.000 0.593 0.407
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.604 0.396
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.604 0.396
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.604 0.396
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.604 0.396
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.604 0.396
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.604 0.396
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.604 0.396
E50-E64 Other nutritional deficiencies
0.000 0.605 0.395
E03.8 Other specified hypothyroidism
0.001 0.635 0.364
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.638 0.362
M06 Other rheumatoid arthritis
0.000 0.655 0.345
E20-E35 Disorders of other endocrine glands
0.000 0.682 0.318
E67.8 Other specified hyperalimentation
0.000 0.684 0.316
E67.3 Hypervitaminosis D
0.000 0.684 0.316
E67.2 Megavitamin-B6 syndrome
0.000 0.684 0.316
E67.1 Hypercarotenaemia
0.000 0.684 0.316
E67.0 Hypervitaminosis A
0.000 0.684 0.316
E51 Thiamine deficiency
0.000 0.699 0.301
M06.4 Inflammatory polyarthropathy
0.000 0.708 0.292
E44.1 Mild protein-energy malnutrition
0.000 0.708 0.292
E44.0 Moderate protein-energy malnutrition
0.000 0.708 0.292
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.717 0.283
E63 Other nutritional deficiencies
0.000 0.717 0.283
E50 Vitamin A deficiency
0.000 0.717 0.283
E60 Dietary zinc deficiency
0.000 0.717 0.283
E59 Dietary selenium deficiency
0.000 0.717 0.283
E54 Ascorbic acid deficiency
0.000 0.717 0.283
E52 Niacin deficiency [pellagra]
0.000 0.717 0.283
E56 Other vitamin deficiencies
0.000 0.720 0.280
E58 Dietary calcium deficiency
0.000 0.721 0.278
E22 Hyperfunction of pituitary gland
0.000 0.722 0.278
R07.4 Chest pain, unspecified
0.000 0.727 0.273
M06.3 Rheumatoid nodule
0.000 0.732 0.268
E46 Unspecified protein-energy malnutrition
0.000 0.737 0.263
E29 Testicular dysfunction
0.000 0.748 0.252
E61 Deficiency of other nutrient elements
0.000 0.749 0.250
M06.8 Other specified rheumatoid arthritis
0.000 0.752 0.248
M06.2 Rheumatoid bursitis
0.000 0.752 0.248
M06.1 Adult-onset Still's disease
0.000 0.752 0.248
E22.1 Hyperprolactinaemia
0.000 0.756 0.244
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.758 0.242
E23 Hypofunction and other disorders of pituitary gland
0.000 0.760 0.240
E70-E90 Metabolic disorders
0.002 0.761 0.236
E51.2 Wernicke's encephalopathy
0.000 0.766 0.234
M06.34 Rheumatoid nodule (Hand)
0.000 0.768 0.232
E55 Vitamin D deficiency
0.000 0.768 0.232
E11.3 With ophthalmic complications
0.000 0.769 0.231
E25 Adrenogenital disorders
0.000 0.769 0.231
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.770 0.229
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.772 0.228
E32 Diseases of thymus
0.000 0.772 0.228
E31 Polyglandular dysfunction
0.000 0.772 0.228
E30 Disorders of puberty, not elsewhere classified
0.000 0.772 0.228
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.776 0.224
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.778 0.222
E85 Amyloidosis
0.001 0.782 0.218
E51.9 Thiamine deficiency, unspecified
0.000 0.784 0.216
E51.8 Other manifestations of thiamine deficiency
0.000 0.784 0.216
E51.1 Beriberi
0.000 0.784 0.216
E24 Cushing's syndrome
0.000 0.786 0.214
E20 Hypoparathyroidism
0.000 0.790 0.210
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.790 0.210
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.790 0.210
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.790 0.210
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.790 0.210
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.790 0.210
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.790 0.210
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.790 0.210
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.790 0.210
E29.1 Testicular hypofunction
0.000 0.795 0.205
E26 Hyperaldosteronism
0.000 0.795 0.205
E50.9 Vitamin A deficiency, unspecified
0.000 0.797 0.203
E50.8 Other manifestations of vitamin A deficiency
0.000 0.797 0.203
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.797 0.203
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.797 0.203
E50.5 Vitamin A deficiency with night blindness
0.000 0.797 0.203
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.797 0.203
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.797 0.203
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.797 0.203
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.797 0.203
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.797 0.203
E63.9 Nutritional deficiency, unspecified
0.000 0.797 0.203
E63.8 Other specified nutritional deficiencies
0.000 0.797 0.203
E63.1 Imbalance of constituents of food intake
0.000 0.797 0.203
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.797 0.203
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.797 0.203
E64.8 Sequelae of other nutritional deficiencies
0.000 0.797 0.203
E64.3 Sequelae of rickets
0.000 0.797 0.203
E64.2 Sequelae of vitamin C deficiency
0.000 0.797 0.203
E64.1 Sequelae of vitamin A deficiency
0.000 0.797 0.203
E64.0 Sequelae of protein-energy malnutrition
0.000 0.797 0.203
E78.2 Mixed hyperlipidaemia
0.000 0.799 0.201
E56.9 Vitamin deficiency, unspecified
0.000 0.799 0.201
E56.8 Deficiency of other vitamins
0.000 0.799 0.201
E56.0 Deficiency of vitamin E
0.000 0.799 0.201
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.800 0.199
E22.8 Other hyperfunction of pituitary gland
0.000 0.800 0.199
E56.1 Deficiency of vitamin K
0.000 0.802 0.198
E23.2 Diabetes insipidus
0.000 0.802 0.198
E85.9 Amyloidosis, unspecified
0.000 0.804 0.196
E83 Disorders of mineral metabolism
0.156 0.804 0.040
E78.0 Pure hypercholesterolaemia
0.000 0.804 0.196
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.805 0.195
E23.6 Other disorders of pituitary gland
0.000 0.807 0.193
M06.0 Seronegative rheumatoid arthritis
0.000 0.807 0.192
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.808 0.192
M06.38 Rheumatoid nodule (Other)
0.000 0.808 0.192
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.808 0.192
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.808 0.192
M06.33 Rheumatoid nodule (Forearm)
0.000 0.808 0.192
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.808 0.192
J45 Asthma
0.000 0.808 0.192
E78.8 Other disorders of lipoprotein metabolism
0.000 0.812 0.188
E22.0 Acromegaly and pituitary gigantism
0.000 0.814 0.186
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.815 0.185
E79 Disorders of purine and pyrimidine metabolism
0.002 0.816 0.183
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.818 0.182
E29.9 Testicular dysfunction, unspecified
0.000 0.819 0.181
E29.8 Other testicular dysfunction
0.000 0.819 0.181
E29.0 Testicular hyperfunction
0.000 0.819 0.181
E61.9 Deficiency of nutrient element, unspecified
0.000 0.820 0.180
E61.8 Deficiency of other specified nutrient elements
0.000 0.820 0.180
E61.7 Deficiency of multiple nutrient elements
0.000 0.820 0.180
E61.6 Vanadium deficiency
0.000 0.820 0.180
E61.5 Molybdenum deficiency
0.000 0.820 0.180
E61.4 Chromium deficiency
0.000 0.820 0.180
E61.3 Manganese deficiency
0.000 0.820 0.180
E61.0 Copper deficiency
0.000 0.820 0.180
E24.2 Drug-induced Cushing's syndrome
0.000 0.821 0.179
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.822 0.178
M06.18 Adult-onset Still's disease (Other)
0.000 0.822 0.178
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.822 0.178
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.822 0.178
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.822 0.178
M06.14 Adult-onset Still's disease (Hand)
0.000 0.822 0.178
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.822 0.178
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.822 0.178
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.822 0.178
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.822 0.178
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.822 0.178
M06.28 Rheumatoid bursitis (Other)
0.000 0.822 0.178
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.822 0.178
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.822 0.178
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.822 0.178
M06.24 Rheumatoid bursitis (Hand)
0.000 0.822 0.178
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.822 0.178
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.822 0.178
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.822 0.178
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.822 0.178
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.822 0.178
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.822 0.178
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.822 0.178
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.822 0.178
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.822 0.178
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.822 0.178
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.822 0.178
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.822 0.178
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.822 0.178
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.822 0.178
E78.5 Hyperlipidaemia, unspecified
0.000 0.824 0.176
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.826 0.173
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.827 0.172
E23.1 Drug-induced hypopituitarism
0.000 0.827 0.172
E89.3 Postprocedural hypopituitarism
0.000 0.828 0.172
E77 Disorders of glycoprotein metabolism
0.002 0.829 0.170
E76 Disorders of glycosaminoglycan metabolism
0.002 0.829 0.170
E72 Other disorders of amino-acid metabolism
0.002 0.829 0.170
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.002 0.829 0.170
E70 Disorders of aromatic amino-acid metabolism
0.002 0.829 0.170
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.002 0.829 0.170
E85.4 Organ-limited amyloidosis
0.000 0.831 0.169
E85.3 Secondary systemic amyloidosis
0.001 0.831 0.169
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.831 0.169
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.831 0.169
E34 Other endocrine disorders
0.000 0.832 0.168
E28 Ovarian dysfunction
0.000 0.832 0.168
E61.2 Magnesium deficiency
0.000 0.833 0.167
E66 Obesity
0.000 0.833 0.167
E55.0 Rickets, active
0.000 0.833 0.166
E25.9 Adrenogenital disorder, unspecified
0.000 0.834 0.166
E25.8 Other adrenogenital disorders
0.000 0.834 0.166
E23.7 Disorder of pituitary gland, unspecified
0.000 0.835 0.165
E78.6 Lipoprotein deficiency
0.000 0.835 0.164
E30.9 Disorder of puberty, unspecified
0.000 0.836 0.163
E30.8 Other disorders of puberty
0.000 0.836 0.163
E30.1 Precocious puberty
0.000 0.836 0.163
E30.0 Delayed puberty
0.000 0.836 0.163
E31.9 Polyglandular dysfunction, unspecified
0.000 0.836 0.163
E31.8 Other polyglandular dysfunction
0.000 0.836 0.163
E31.1 Polyglandular hyperfunction
0.000 0.836 0.163
E31.0 Autoimmune polyglandular failure
0.000 0.836 0.163
E32.9 Disease of thymus, unspecified
0.000 0.836 0.163
E32.8 Other diseases of thymus
0.000 0.836 0.163
E32.1 Abscess of thymus
0.000 0.836 0.163
E32.0 Persistent hyperplasia of thymus
0.000 0.836 0.163
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.836 0.163
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.836 0.163
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.836 0.163
E61.1 Iron deficiency
0.000 0.837 0.163
E78.1 Pure hyperglyceridaemia
0.000 0.838 0.162
L40.9 Psoriasis, unspecified
0.162 0.838 0.000
E78.3 Hyperchylomicronaemia
0.000 0.839 0.160
E85.8 Other amyloidosis
0.001 0.843 0.156
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.843 0.156
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.843 0.156
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.843 0.156
E74 Other disorders of carbohydrate metabolism
0.002 0.846 0.152
E24.8 Other Cushing's syndrome
0.000 0.847 0.153
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.847 0.153
E24.3 Ectopic ACTH syndrome
0.000 0.847 0.153
E24.1 Nelson's syndrome
0.000 0.847 0.153
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.847 0.153
E20.8 Other hypoparathyroidism
0.000 0.849 0.151
E20.1 Pseudohypoparathyroidism
0.000 0.849 0.151
E20.0 Idiopathic hypoparathyroidism
0.000 0.849 0.151
E84 Cystic fibrosis
0.002 0.849 0.149
E73 Lactose intolerance
0.002 0.851 0.147
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.002 0.851 0.147
E26.9 Hyperaldosteronism, unspecified
0.000 0.853 0.147
E26.8 Other hyperaldosteronism
0.000 0.853 0.147
E26.1 Secondary hyperaldosteronism
0.000 0.853 0.147
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.853 0.147
E78.4 Other hyperlipidaemia
0.000 0.854 0.146
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.855 0.144
E83.3 Disorders of phosphorus metabolism
0.130 0.857 0.012
E53 Deficiency of other B group vitamins
0.000 0.859 0.141
E83.9 Disorder of mineral metabolism, unspecified
0.112 0.859 0.029
E83.8 Other disorders of mineral metabolism
0.112 0.859 0.029
E83.2 Disorders of zinc metabolism
0.112 0.859 0.029
E83.0 Disorders of copper metabolism
0.112 0.859 0.029
E66.0 Obesity due to excess calories
0.000 0.859 0.140
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.860 0.140
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.860 0.140
E89.5 Postprocedural testicular hypofunction
0.000 0.860 0.140
E89.1 Postprocedural hypoinsulinaemia
0.000 0.860 0.140
J45.8 Mixed asthma
0.000 0.860 0.140
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.862 0.138
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.862 0.138
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.862 0.138
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.862 0.138
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.862 0.138
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.862 0.138
J45.1 Nonallergic asthma
0.000 0.862 0.138
E89.2 Postprocedural hypoparathyroidism
0.000 0.864 0.136
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.865 0.135
E20.9 Hypoparathyroidism, unspecified
0.000 0.867 0.133
E04 Other non-toxic goitre
0.000 0.867 0.133
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.868 0.131
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.868 0.131
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.868 0.131
E79.1 Lesch-Nyhan syndrome
0.001 0.868 0.131
E24.0 Pituitary-dependent Cushing's disease
0.000 0.869 0.131
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.870 0.130
E89.4 Postprocedural ovarian failure
0.000 0.872 0.128
E23.0 Hypopituitarism
0.000 0.873 0.126
E89.0 Postprocedural hypothyroidism
0.000 0.875 0.125
E26.0 Primary hyperaldosteronism
0.000 0.875 0.125
E34.8 Other specified endocrine disorders
0.000 0.876 0.124
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.877 0.122
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.877 0.122
E70.3 Albinism
0.001 0.877 0.122
E70.2 Disorders of tyrosine metabolism
0.001 0.877 0.122
E70.1 Other hyperphenylalaninaemias
0.001 0.877 0.122
E70.0 Classical phenylketonuria
0.001 0.877 0.122
E71.3 Disorders of fatty-acid metabolism
0.001 0.877 0.122
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.877 0.122
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.877 0.122
E71.0 Maple-syrup-urine disease
0.001 0.877 0.122
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.877 0.122
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.877 0.122
E72.5 Disorders of glycine metabolism
0.001 0.877 0.122
E72.4 Disorders of ornithine metabolism
0.001 0.877 0.122
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.877 0.122
E72.2 Disorders of urea cycle metabolism
0.001 0.877 0.122
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.877 0.122
E72.0 Disorders of amino-acid transport
0.001 0.877 0.122
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.877 0.122
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.877 0.122
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.877 0.122
E76.2 Other mucopolysaccharidoses
0.001 0.877 0.122
E76.1 Mucopolysaccharidosis, type II
0.001 0.877 0.122
E76.0 Mucopolysaccharidosis, type I
0.001 0.877 0.122
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.877 0.122
E77.8 Other disorders of glycoprotein metabolism
0.001 0.877 0.122
E77.1 Defects in glycoprotein degradation
0.001 0.877 0.122
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.877 0.122
E21.4 Other specified disorders of parathyroid gland
0.000 0.879 0.121
E21.2 Other hyperparathyroidism
0.000 0.879 0.121
E34.5 Androgen resistance syndrome
0.000 0.879 0.121
E34.4 Constitutional tall stature
0.000 0.879 0.121
E34.3 Short stature, not elsewhere classified
0.000 0.879 0.121
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.879 0.121
E34.1 Other hypersecretion of intestinal hormones
0.000 0.879 0.121
E28.9 Ovarian dysfunction, unspecified
0.000 0.879 0.120
E28.8 Other ovarian dysfunction
0.000 0.879 0.120
E28.1 Androgen excess
0.000 0.879 0.120
E28.0 Oestrogen excess
0.000 0.879 0.120
E28.3 Primary ovarian failure
0.000 0.880 0.120
E66.1 Drug-induced obesity
0.000 0.880 0.120
E24.9 Cushing's syndrome, unspecified
0.000 0.881 0.118
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.884 0.116
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.884 0.116
E55.9 Vitamin D deficiency, unspecified
0.000 0.885 0.115
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.885 0.115
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.887 0.112
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.889 0.109
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.889 0.109
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.889 0.109
E74.2 Disorders of galactose metabolism
0.001 0.889 0.109
E74.1 Disorders of fructose metabolism
0.001 0.889 0.109
E84.8 Cystic fibrosis with other manifestations
0.002 0.892 0.107
E84.1 Cystic fibrosis with intestinal manifestations
0.002 0.892 0.107
E34.0 Carcinoid syndrome
0.000 0.892 0.108
E73.8 Other lactose intolerance
0.001 0.893 0.106
E73.1 Secondary lactase deficiency
0.001 0.893 0.106
E73.0 Congenital lactase deficiency
0.001 0.893 0.106
E75.6 Lipid storage disorder, unspecified
0.002 0.893 0.105
E75.4 Neuronal ceroid lipofuscinosis
0.002 0.893 0.105
E75.3 Sphingolipidosis, unspecified
0.002 0.893 0.105
E75.1 Other gangliosidosis
0.002 0.893 0.105
E75.0 GM2 gangliosidosis
0.002 0.893 0.105
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.894 0.106
L40 Psoriasis
0.106 0.894 0.000
E75.5 Other lipid storage disorders
0.002 0.895 0.103
E53.1 Pyridoxine deficiency
0.000 0.899 0.101
E53.0 Riboflavin deficiency
0.000 0.899 0.101
E84.9 Cystic fibrosis, unspecified
0.002 0.900 0.099
E21.3 Hyperparathyroidism, unspecified
0.000 0.901 0.099
E84.0 Cystic fibrosis with pulmonary manifestations
0.002 0.902 0.096
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.903 0.097
E80.6 Other disorders of bilirubin metabolism
0.001 0.904 0.095
E04.8 Other specified non-toxic goitre
0.000 0.905 0.095
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.905 0.094
E80.5 Crigler-Najjar syndrome
0.001 0.905 0.094
E80.3 Defects of catalase and peroxydase
0.001 0.905 0.094
E80.2 Other porphyria
0.001 0.905 0.094
E80.1 Porphyria cutanea tarda
0.001 0.905 0.094
E80.0 Hereditary erythropoietic porphyria
0.001 0.905 0.094
L40.0 Psoriasis vulgaris
0.094 0.906 0.000
E27 Other disorders of adrenal gland
0.000 0.909 0.091
E74.0 Glycogen storage disease
0.002 0.909 0.089

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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