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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3093993
log Bayes Factor = 49.0311
Chromosome 6   position 31,490,725  (GRCh37) Explore rs3093993 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.003 0.997
E05.9 Thyrotoxicosis, unspecified
0.000 0.004 0.996
E00-E07 Disorders of thyroid gland
0.000 0.005 0.995
E11 Non-insulin-dependent diabetes mellitus
0.000 0.007 0.993
E11.9 Without complications
0.000 0.009 0.991
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.011 0.989
E14.3 With ophthalmic complications
0.000 0.012 0.988
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.012 0.988
J45.9 Asthma, unspecified
0.000 0.016 0.984
E10.1 With ketoacidosis
0.000 0.022 0.978
E10.4 With neurological complications
0.000 0.029 0.971
E03 Other hypothyroidism
0.000 0.031 0.969
E14.9 Without complications
0.000 0.031 0.969
E03.9 Hypothyroidism, unspecified
0.000 0.035 0.965
E10.2 With renal complications
0.000 0.076 0.924
E11.0 With coma
0.000 0.079 0.921
M06.9 Rheumatoid arthritis, unspecified
0.000 0.138 0.862
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.141 0.859
E14.8 With unspecified complications
0.000 0.157 0.843
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.165 0.835
E10.8 With unspecified complications
0.000 0.197 0.803
G35-G37 Demyelinating diseases of the central nervous system
0.801 0.199 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.204 0.796
E13 Other specified diabetes mellitus
0.000 0.205 0.795
E10.0 With coma
0.000 0.209 0.791
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.209 0.791
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.218 0.782
E11.5 With peripheral circulatory complications
0.000 0.224 0.776
E10.5 With peripheral circulatory complications
0.000 0.227 0.773
E07 Other disorders of thyroid
0.000 0.236 0.764
E14.6 With other specified complications
0.000 0.237 0.763
G37 Other demyelinating diseases of central nervous system
0.760 0.240 0.000
E83.1 Disorders of iron metabolism
0.753 0.247 0.000
E14.1 With ketoacidosis
0.000 0.252 0.748
E14.5 With peripheral circulatory complications
0.000 0.257 0.743
E14.4 With neurological complications
0.000 0.263 0.737
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.272 0.728
E06 Thyroiditis
0.000 0.280 0.720
E10.7 With multiple complications
0.000 0.283 0.717
E10.6 With other specified complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.716
E14.2 Withrenal complications
0.000 0.283 0.716
E14.0 With coma
0.000 0.283 0.716
E05.5 Thyroid crisis or storm
0.000 0.285 0.715
E05.4 Thyrotoxicosis factitia
0.000 0.285 0.715
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.285 0.715
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.285 0.715
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.286 0.714
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.287 0.713
E00 Congenital iodine-deficiency syndrome
0.000 0.287 0.713
G37.9 Demyelinating disease of central nervous system, unspecified
0.713 0.287 0.000
E11.7 With multiple complications
0.000 0.288 0.712
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.300 0.700
E03.5 Myxoedema coma
0.000 0.305 0.695
E03.4 Atrophy of thyroid (acquired)
0.000 0.305 0.695
E03.3 Postinfectious hypothyroidism
0.000 0.305 0.695
E11.2 With renal complications
0.000 0.312 0.688
E11.1 With ketoacidosis
0.000 0.315 0.685
E03.1 Congenital hypothyroidism without goitre
0.000 0.321 0.679
E05.8 Other thyrotoxicosis
0.000 0.330 0.670
E11.6 With other specified complications
0.000 0.332 0.668
K90 Intestinal malabsorption
0.000 0.333 0.667
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.333 0.667
E13.9 Without complications
0.000 0.345 0.655
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.351 0.649
E16 Other disorders of pancreatic internal secretion
0.000 0.352 0.648
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.361 0.639
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.365 0.635
G37.8 Other specified demyelinating diseases of central nervous system
0.633 0.367 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.372 0.628
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.376 0.624
K90.9 Intestinal malabsorption, unspecified
0.000 0.380 0.620
E40-E46 Malnutrition
0.000 0.392 0.608
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.399 0.601
M45 Ankylosing spondylitis
0.000 0.403 0.597
E65-E68 Obesity and other hyperalimentation
0.000 0.409 0.590
G36 Other acute disseminated demyelination
0.577 0.423 0.000
E06.9 Thyroiditis, unspecified
0.000 0.428 0.572
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.429 0.570
E13.8 With unspecified complications
0.000 0.430 0.570
E13.7 With multiple complications
0.000 0.430 0.570
E13.6 With other specified complications
0.000 0.430 0.570
E13.5 With peripheral circulatory complications
0.000 0.430 0.570
E13.4 With neurological complications
0.000 0.430 0.570
E13.2 With renal complications
0.000 0.430 0.570
E13.1 With ketoacidosis
0.000 0.430 0.570
E13.0 With coma
0.000 0.430 0.570
E15 Nondiabetic hypoglycaemic coma
0.000 0.433 0.567
E11.8 With unspecified complications
0.000 0.433 0.566
E13.3 With ophthalmic complications
0.000 0.442 0.558
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.450 0.550
E07.1 Dyshormogenetic goitre
0.000 0.452 0.548
E07.0 Hypersecretion of calcitonin
0.000 0.452 0.548
G37.5 Concentric sclerosis [Balo]
0.545 0.455 0.000
G37.4 Subacute necrotising myelitis
0.545 0.455 0.000
G37.2 Central pontine myelinolysis
0.545 0.455 0.000
G37.1 Central demyelination of corpus callosum
0.545 0.455 0.000
G37.0 Diffuse sclerosis
0.545 0.455 0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.531 0.469 0.000
E16.1 Other hypoglycaemia
0.000 0.483 0.517
E06.5 Other chronic thyroiditis
0.000 0.483 0.517
E06.4 Drug-induced thyroiditis
0.000 0.483 0.517
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.483 0.517
E06.1 Subacute thyroiditis
0.000 0.483 0.517
E06.0 Acute thyroiditis
0.000 0.483 0.517
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.488 0.511
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.488 0.511
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.488 0.511
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.488 0.511
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.488 0.511
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.488 0.511
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.488 0.511
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.488 0.511
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.493 0.507
E16.2 Hypoglycaemia, unspecified
0.000 0.493 0.507
E07.8 Other specified disorders of thyroid
0.000 0.497 0.503
K90.8 Other intestinal malabsorption
0.000 0.512 0.488
E65 Localised adiposity
0.000 0.517 0.483
K90.3 Pancreatic steatorrhoea
0.000 0.521 0.478
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.521 0.478
K90.1 Tropical sprue
0.000 0.521 0.478
M06 Other rheumatoid arthritis
0.000 0.530 0.470
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.534 0.466
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.535 0.465
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.535 0.465
E16.4 Abnormal secretion of gastrin
0.000 0.535 0.465
E16.3 Increased secretion of glucagon
0.000 0.535 0.465
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.536 0.464
E06.3 Autoimmune thyroiditis
0.000 0.550 0.450
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.564 0.436
E45 Retarded development following protein-energy malnutrition
0.000 0.564 0.436
E43 Unspecified severe protein-energy malnutrition
0.000 0.564 0.436
E42 Marasmic kwashiorkor
0.000 0.564 0.436
E41 Nutritional marasmus
0.000 0.564 0.436
E40 Kwashiorkor
0.000 0.564 0.436
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.572 0.428
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.572 0.428
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.572 0.428
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.572 0.428
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.572 0.428
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.572 0.428
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.572 0.428
E67 Other hyperalimentation
0.000 0.576 0.423
E68 Sequelae of hyperalimentation
0.000 0.576 0.423
G36.0 Neuromyelitis optica [Devic]
0.417 0.583 0.000
G36.9 Acute disseminated demyelination, unspecified
0.414 0.586 0.000
G36.8 Other specified acute disseminated demyelination
0.414 0.586 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.414 0.586 0.000
M06.4 Inflammatory polyarthropathy
0.000 0.592 0.408
E50-E64 Other nutritional deficiencies
0.000 0.596 0.404
E11.4 With neurological complications
0.000 0.615 0.385
E03.8 Other specified hypothyroidism
0.001 0.635 0.364
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.636 0.364
M06.3 Rheumatoid nodule
0.000 0.644 0.356
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.648 0.352
M06.8 Other specified rheumatoid arthritis
0.000 0.663 0.337
M06.2 Rheumatoid bursitis
0.000 0.663 0.337
M06.1 Adult-onset Still's disease
0.000 0.663 0.337
E46 Unspecified protein-energy malnutrition
0.000 0.664 0.335
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.682 0.317
E44.1 Mild protein-energy malnutrition
0.000 0.687 0.313
E44.0 Moderate protein-energy malnutrition
0.000 0.687 0.313
E51 Thiamine deficiency
0.000 0.693 0.307
M06.34 Rheumatoid nodule (Hand)
0.000 0.694 0.306
E67.8 Other specified hyperalimentation
0.000 0.696 0.304
E67.3 Hypervitaminosis D
0.000 0.696 0.304
E67.2 Megavitamin-B6 syndrome
0.000 0.696 0.304
E67.1 Hypercarotenaemia
0.000 0.696 0.304
E67.0 Hypervitaminosis A
0.000 0.696 0.304
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.707 0.293
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.707 0.293
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.707 0.293
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.707 0.293
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.707 0.293
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.707 0.293
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.707 0.293
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.707 0.293
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.710 0.290
E63 Other nutritional deficiencies
0.000 0.710 0.290
E50 Vitamin A deficiency
0.000 0.710 0.290
E60 Dietary zinc deficiency
0.000 0.710 0.290
E59 Dietary selenium deficiency
0.000 0.710 0.290
E58 Dietary calcium deficiency
0.000 0.710 0.290
E54 Ascorbic acid deficiency
0.000 0.710 0.290
E52 Niacin deficiency [pellagra]
0.000 0.710 0.290
E56 Other vitamin deficiencies
0.000 0.714 0.286
R07.4 Chest pain, unspecified
0.000 0.733 0.267
M06.0 Seronegative rheumatoid arthritis
0.000 0.743 0.257
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.744 0.256
M06.38 Rheumatoid nodule (Other)
0.000 0.744 0.256
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.744 0.256
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.744 0.256
M06.33 Rheumatoid nodule (Forearm)
0.000 0.744 0.256
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.744 0.256
E20-E35 Disorders of other endocrine glands
0.000 0.751 0.249
E61 Deficiency of other nutrient elements
0.000 0.751 0.249
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.755 0.245
E55 Vitamin D deficiency
0.000 0.756 0.244
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.758 0.241
M06.18 Adult-onset Still's disease (Other)
0.000 0.758 0.241
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.758 0.241
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.758 0.241
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.758 0.241
M06.14 Adult-onset Still's disease (Hand)
0.000 0.758 0.241
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.758 0.241
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.758 0.241
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.758 0.241
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.758 0.241
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.758 0.241
M06.28 Rheumatoid bursitis (Other)
0.000 0.758 0.241
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.758 0.241
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.758 0.241
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.758 0.241
M06.24 Rheumatoid bursitis (Hand)
0.000 0.758 0.241
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.758 0.241
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.758 0.241
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.758 0.241
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.758 0.241
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.758 0.241
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.758 0.241
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.758 0.241
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.758 0.241
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.758 0.241
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.758 0.241
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.758 0.241
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.758 0.241
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.758 0.241
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.758 0.241
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.760 0.240
E51.2 Wernicke's encephalopathy
0.000 0.762 0.238
J45 Asthma
0.000 0.766 0.233
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.771 0.229
E51.9 Thiamine deficiency, unspecified
0.000 0.780 0.220
E51.8 Other manifestations of thiamine deficiency
0.000 0.780 0.220
E51.1 Beriberi
0.000 0.780 0.220
E22 Hyperfunction of pituitary gland
0.000 0.782 0.218
E50.9 Vitamin A deficiency, unspecified
0.000 0.792 0.208
E50.8 Other manifestations of vitamin A deficiency
0.000 0.792 0.208
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.792 0.208
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.792 0.208
E50.5 Vitamin A deficiency with night blindness
0.000 0.792 0.208
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.792 0.208
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.792 0.208
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.792 0.208
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.792 0.208
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.792 0.208
E63.9 Nutritional deficiency, unspecified
0.000 0.792 0.208
E63.8 Other specified nutritional deficiencies
0.000 0.792 0.208
E63.1 Imbalance of constituents of food intake
0.000 0.792 0.208
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.792 0.208
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.792 0.208
E64.8 Sequelae of other nutritional deficiencies
0.000 0.792 0.208
E64.3 Sequelae of rickets
0.000 0.792 0.208
E64.2 Sequelae of vitamin C deficiency
0.000 0.792 0.208
E64.1 Sequelae of vitamin A deficiency
0.000 0.792 0.208
E64.0 Sequelae of protein-energy malnutrition
0.000 0.792 0.208
E83 Disorders of mineral metabolism
0.186 0.793 0.021
E56.9 Vitamin deficiency, unspecified
0.000 0.795 0.205
E56.8 Deficiency of other vitamins
0.000 0.795 0.205
E56.0 Deficiency of vitamin E
0.000 0.795 0.205
E29 Testicular dysfunction
0.000 0.796 0.204
E56.1 Deficiency of vitamin K
0.000 0.798 0.202
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.803 0.197
E22.1 Hyperprolactinaemia
0.000 0.810 0.190
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.815 0.185
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.815 0.185
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.815 0.185
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.815 0.185
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.815 0.185
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.815 0.185
E25 Adrenogenital disorders
0.000 0.819 0.181
E70-E90 Metabolic disorders
0.004 0.820 0.176
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.820 0.180
E11.3 With ophthalmic complications
0.000 0.821 0.179
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.821 0.179
E32 Diseases of thymus
0.000 0.821 0.179
E31 Polyglandular dysfunction
0.000 0.821 0.179
E30 Disorders of puberty, not elsewhere classified
0.000 0.821 0.179
E61.9 Deficiency of nutrient element, unspecified
0.000 0.821 0.178
E61.8 Deficiency of other specified nutrient elements
0.000 0.821 0.178
E61.7 Deficiency of multiple nutrient elements
0.000 0.821 0.178
E61.6 Vanadium deficiency
0.000 0.821 0.178
E61.5 Molybdenum deficiency
0.000 0.821 0.178
E61.4 Chromium deficiency
0.000 0.821 0.178
E61.3 Manganese deficiency
0.000 0.821 0.178
E61.0 Copper deficiency
0.000 0.821 0.178
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.823 0.177
E23 Hypofunction and other disorders of pituitary gland
0.000 0.823 0.176
E55.0 Rickets, active
0.000 0.825 0.175
E61.2 Magnesium deficiency
0.000 0.828 0.172
E29.1 Testicular hypofunction
0.000 0.829 0.171
J45.8 Mixed asthma
0.000 0.830 0.169
J45.1 Nonallergic asthma
0.000 0.832 0.167
E83.3 Disorders of phosphorus metabolism
0.160 0.834 0.006
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.835 0.165
E20 Hypoparathyroidism
0.000 0.836 0.164
E24 Cushing's syndrome
0.000 0.837 0.163
E04 Other non-toxic goitre
0.000 0.837 0.163
E26 Hyperaldosteronism
0.000 0.838 0.162
E85 Amyloidosis
0.001 0.839 0.160
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.844 0.156
E22.8 Other hyperfunction of pituitary gland
0.000 0.844 0.156
E53 Deficiency of other B group vitamins
0.000 0.849 0.151
E78.0 Pure hypercholesterolaemia
0.000 0.850 0.150
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.851 0.149
E83.9 Disorder of mineral metabolism, unspecified
0.134 0.851 0.015
E83.8 Other disorders of mineral metabolism
0.134 0.851 0.015
E83.2 Disorders of zinc metabolism
0.134 0.851 0.015
E83.0 Disorders of copper metabolism
0.134 0.851 0.015
E66 Obesity
0.000 0.853 0.147
E61.1 Iron deficiency
0.000 0.853 0.147
E78.2 Mixed hyperlipidaemia
0.000 0.853 0.146
E29.9 Testicular dysfunction, unspecified
0.000 0.854 0.146
E29.8 Other testicular dysfunction
0.000 0.854 0.146
E29.0 Testicular hyperfunction
0.000 0.854 0.146
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.001 0.855 0.144
E23.2 Diabetes insipidus
0.000 0.857 0.143
E85.9 Amyloidosis, unspecified
0.001 0.857 0.142
E22.0 Acromegaly and pituitary gigantism
0.000 0.858 0.142
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.859 0.141
E23.6 Other disorders of pituitary gland
0.000 0.861 0.139
E79 Disorders of purine and pyrimidine metabolism
0.003 0.861 0.136
E24.2 Drug-induced Cushing's syndrome
0.000 0.864 0.136
E28 Ovarian dysfunction
0.000 0.865 0.135
E34 Other endocrine disorders
0.000 0.867 0.133
E78.8 Other disorders of lipoprotein metabolism
0.000 0.867 0.133
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.868 0.132
E25.9 Adrenogenital disorder, unspecified
0.000 0.870 0.130
E25.8 Other adrenogenital disorders
0.000 0.870 0.130
E55.9 Vitamin D deficiency, unspecified
0.000 0.870 0.130
E77 Disorders of glycoprotein metabolism
0.003 0.870 0.127
E76 Disorders of glycosaminoglycan metabolism
0.003 0.870 0.127
E72 Other disorders of amino-acid metabolism
0.003 0.870 0.127
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.003 0.870 0.127
E70 Disorders of aromatic amino-acid metabolism
0.003 0.870 0.127
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.003 0.870 0.127
E30.9 Disorder of puberty, unspecified
0.000 0.871 0.128
E30.8 Other disorders of puberty
0.000 0.871 0.128
E30.1 Precocious puberty
0.000 0.871 0.128
E30.0 Delayed puberty
0.000 0.871 0.128
E31.9 Polyglandular dysfunction, unspecified
0.000 0.871 0.128
E31.8 Other polyglandular dysfunction
0.000 0.871 0.128
E31.1 Polyglandular hyperfunction
0.000 0.871 0.128
E31.0 Autoimmune polyglandular failure
0.000 0.871 0.128
E32.9 Disease of thymus, unspecified
0.000 0.871 0.128
E32.8 Other diseases of thymus
0.000 0.871 0.128
E32.1 Abscess of thymus
0.000 0.871 0.128
E32.0 Persistent hyperplasia of thymus
0.000 0.871 0.128
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.871 0.128
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.871 0.128
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.871 0.128
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.873 0.127
E23.1 Drug-induced hypopituitarism
0.000 0.873 0.127
E85.4 Organ-limited amyloidosis
0.001 0.874 0.125
E89.3 Postprocedural hypopituitarism
0.000 0.875 0.125
E66.0 Obesity due to excess calories
0.000 0.877 0.123
E78.5 Hyperlipidaemia, unspecified
0.000 0.877 0.123
E85.3 Secondary systemic amyloidosis
0.001 0.878 0.121
E74 Other disorders of carbohydrate metabolism
0.003 0.878 0.119
E78.6 Lipoprotein deficiency
0.000 0.879 0.121
E23.7 Disorder of pituitary gland, unspecified
0.000 0.880 0.120
E78.3 Hyperchylomicronaemia
0.000 0.881 0.118
E78.1 Pure hyperglyceridaemia
0.000 0.882 0.118
E20.8 Other hypoparathyroidism
0.000 0.882 0.117
E20.1 Pseudohypoparathyroidism
0.000 0.882 0.117
E20.0 Idiopathic hypoparathyroidism
0.000 0.882 0.117
E24.8 Other Cushing's syndrome
0.000 0.883 0.117
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.883 0.117
E24.3 Ectopic ACTH syndrome
0.000 0.883 0.117
E24.1 Nelson's syndrome
0.000 0.883 0.117
E04.8 Other specified non-toxic goitre
0.000 0.883 0.117
E26.9 Hyperaldosteronism, unspecified
0.000 0.884 0.116
E26.8 Other hyperaldosteronism
0.000 0.884 0.116
E26.1 Secondary hyperaldosteronism
0.000 0.884 0.116
E85.8 Other amyloidosis
0.001 0.884 0.115
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.884 0.115
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.884 0.115
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.884 0.115
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.885 0.115
E84 Cystic fibrosis
0.003 0.886 0.111
E73 Lactose intolerance
0.003 0.887 0.110
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.887 0.112
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.003 0.888 0.109
E78.4 Other hyperlipidaemia
0.000 0.889 0.111
E53.1 Pyridoxine deficiency
0.000 0.891 0.108
E53.0 Riboflavin deficiency
0.000 0.891 0.108
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.002 0.891 0.107
E66.1 Drug-induced obesity
0.000 0.894 0.105
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.001 0.896 0.104
E89.8 Other postprocedural endocrine and metabolic disorders
0.001 0.896 0.104
E89.5 Postprocedural testicular hypofunction
0.001 0.896 0.104
E89.1 Postprocedural hypoinsulinaemia
0.001 0.896 0.104
E20.9 Hypoparathyroidism, unspecified
0.000 0.898 0.102
E80 Disorders of porphyrin and bilirubin metabolism
0.002 0.899 0.099
E89.2 Postprocedural hypoparathyroidism
0.000 0.899 0.101
E28.3 Primary ovarian failure
0.000 0.900 0.100
E34.8 Other specified endocrine disorders
0.000 0.900 0.099
E24.0 Pituitary-dependent Cushing's disease
0.000 0.900 0.099
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.002 0.900 0.098
E79.8 Other disorders of purine and pyrimidine metabolism
0.002 0.900 0.098
E79.1 Lesch-Nyhan syndrome
0.002 0.900 0.098
E04.0 Non-toxic diffuse goitre
0.000 0.901 0.099
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.901 0.099
E26.0 Primary hyperaldosteronism
0.000 0.901 0.099
E89.0 Postprocedural hypothyroidism
0.000 0.902 0.098
E28.9 Ovarian dysfunction, unspecified
0.000 0.903 0.097
E28.8 Other ovarian dysfunction
0.000 0.903 0.097
E28.1 Androgen excess
0.000 0.903 0.097
E28.0 Oestrogen excess
0.000 0.903 0.097
E34.5 Androgen resistance syndrome
0.000 0.904 0.096
E34.4 Constitutional tall stature
0.000 0.904 0.096
E34.3 Short stature, not elsewhere classified
0.000 0.904 0.096
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.904 0.096
E34.1 Other hypersecretion of intestinal hormones
0.000 0.904 0.096
E89.4 Postprocedural ovarian failure
0.001 0.905 0.094
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.002 0.907 0.091
E70.8 Other disorders of aromatic amino-acid metabolism
0.002 0.907 0.091
E70.3 Albinism
0.002 0.907 0.091
E70.2 Disorders of tyrosine metabolism
0.002 0.907 0.091
E70.1 Other hyperphenylalaninaemias
0.002 0.907 0.091
E70.0 Classical phenylketonuria
0.002 0.907 0.091
E71.3 Disorders of fatty-acid metabolism
0.002 0.907 0.091
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.002 0.907 0.091
E71.1 Other disorders of branched-chain amino-acid metabolism
0.002 0.907 0.091
E71.0 Maple-syrup-urine disease
0.002 0.907 0.091
E72.9 Disorder of amino-acid metabolism, unspecified
0.002 0.907 0.091
E72.8 Other specified disorders of amino-acid metabolism
0.002 0.907 0.091
E72.5 Disorders of glycine metabolism
0.002 0.907 0.091
E72.4 Disorders of ornithine metabolism
0.002 0.907 0.091
E72.3 Disorders of lysine and hydroxylysine metabolism
0.002 0.907 0.091
E72.2 Disorders of urea cycle metabolism
0.002 0.907 0.091
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.002 0.907 0.091
E72.0 Disorders of amino-acid transport
0.002 0.907 0.091
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.002 0.907 0.091
E76.8 Other disorders of glucosaminoglycan metabolism
0.002 0.907 0.091
E76.3 Mucopolysaccharidosis, unspecified
0.002 0.907 0.091
E76.2 Other mucopolysaccharidoses
0.002 0.907 0.091
E76.1 Mucopolysaccharidosis, type II
0.002 0.907 0.091
E76.0 Mucopolysaccharidosis, type I
0.002 0.907 0.091
E77.9 Disorder of glycoprotein metabolism, unspecified
0.002 0.907 0.091
E77.8 Other disorders of glycoprotein metabolism
0.002 0.907 0.091
E77.1 Defects in glycoprotein degradation
0.002 0.907 0.091
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.002 0.907 0.091
E74.3 Other disorders of intestinal carbohydrate absorption
0.002 0.907 0.091
E53.9 Vitamin B deficiency, unspecified
0.000 0.912 0.087
E74.9 Disorder of carbohydrate metabolism, unspecified
0.002 0.912 0.085
E74.8 Other specified disorders of carbohydrate metabolism
0.002 0.912 0.085
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.002 0.912 0.085
E74.2 Disorders of galactose metabolism
0.002 0.912 0.085
E74.1 Disorders of fructose metabolism
0.002 0.912 0.085
E23.0 Hypopituitarism
0.000 0.914 0.086
E24.9 Cushing's syndrome, unspecified
0.000 0.914 0.086
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.915 0.085
E04.9 Non-toxic goitre, unspecified
0.000 0.915 0.085
E34.0 Carcinoid syndrome
0.000 0.915 0.084
E21.4 Other specified disorders of parathyroid gland
0.000 0.917 0.083
E21.2 Other hyperparathyroidism
0.000 0.917 0.083
E84.8 Cystic fibrosis with other manifestations
0.002 0.918 0.080
E84.1 Cystic fibrosis with intestinal manifestations
0.002 0.918 0.080
E73.8 Other lactose intolerance
0.002 0.919 0.079
E73.1 Secondary lactase deficiency
0.002 0.919 0.079
E73.0 Congenital lactase deficiency
0.002 0.919 0.079
E75.6 Lipid storage disorder, unspecified
0.003 0.919 0.078
E75.4 Neuronal ceroid lipofuscinosis
0.003 0.919 0.078
E75.3 Sphingolipidosis, unspecified
0.003 0.919 0.078
E75.1 Other gangliosidosis
0.003 0.919 0.078
E75.0 GM2 gangliosidosis
0.003 0.919 0.078
E04.1 Non-toxic single thyroid nodule
0.000 0.920 0.080
H00.1 Chalazion
0.080 0.920 0.000
E75.5 Other lipid storage disorders
0.002 0.921 0.077
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.921 0.079
E83.5 Disorders of calcium metabolism
0.076 0.921 0.002
E80.6 Other disorders of bilirubin metabolism
0.002 0.924 0.074
E84.9 Cystic fibrosis, unspecified
0.003 0.924 0.073
E84.0 Cystic fibrosis with pulmonary manifestations
0.003 0.926 0.072
E80.7 Disorder of bilirubin metabolism, unspecified
0.002 0.927 0.071
E80.5 Crigler-Najjar syndrome
0.002 0.927 0.071
E80.3 Defects of catalase and peroxydase
0.002 0.927 0.071
E80.2 Other porphyria
0.002 0.927 0.071
E80.1 Porphyria cutanea tarda
0.002 0.927 0.071
E80.0 Hereditary erythropoietic porphyria
0.002 0.927 0.071
E74.0 Glycogen storage disease
0.003 0.928 0.069

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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