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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3094691
log Bayes Factor = 96.3133
Chromosome 6   position 31,274,693  (GRCh37) Explore rs3094691 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
D86 Sarcoidosis
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
D86.9 Sarcoidosis, unspecified
0.000 0.000 1.000
G35 Multiple sclerosis
0.000 0.001 0.999
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.001 0.999
R31 Unspecified haematuria
0.999 0.001 0.000
L40.5 Arthropathic psoriasis
0.000 0.001 0.999
D80-D89 Certain disorders involving the immune mechanism
0.000 0.001 0.999
D50-D53 Nutritional anaemias
0.000 0.001 0.999
M45 Ankylosing spondylitis
0.998 0.002 0.000
E10.1 With ketoacidosis
0.000 0.003 0.997
D51 Vitamin B12 deficiency anaemia
0.000 0.004 0.996
E05.9 Thyrotoxicosis, unspecified
0.000 0.004 0.996
E50-E64 Other nutritional deficiencies
0.000 0.007 0.993
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.008 0.992
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.991 0.009 0.000
L40.0 Psoriasis vulgaris
0.000 0.009 0.991
E53 Deficiency of other B group vitamins
0.000 0.021 0.979
D50 Iron deficiency anaemia
0.000 0.026 0.974
E20-E35 Disorders of other endocrine glands
0.000 0.027 0.973
E27 Other disorders of adrenal gland
0.000 0.028 0.972
E27.1 Primary adrenocortical insufficiency
0.000 0.029 0.971
D50.9 Iron deficiency anaemia, unspecified
0.000 0.031 0.969
E55 Vitamin D deficiency
0.000 0.033 0.967
E53.8 Deficiency of other specified B group vitamins
0.000 0.034 0.966
E10.2 With renal complications
0.000 0.037 0.963
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.038 0.962
E14 Unspecified diabetes mellitus
0.000 0.051 0.949
E55.9 Vitamin D deficiency, unspecified
0.000 0.052 0.948
D86.1 Sarcoidosis of lymph nodes
0.000 0.055 0.945
D86.0 Sarcoidosis of lung
0.000 0.064 0.936
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.080 0.920
D55-D59 Haemolytic anaemias
0.000 0.081 0.919
E06 Thyroiditis
0.000 0.082 0.918
D69 Purpura and other haemorrhagic conditions
0.000 0.086 0.914
M45.X2 Ankylosing spondylitis (Cervical region)
0.911 0.089 0.000
E10.4 With neurological complications
0.000 0.092 0.908
E14.3 With ophthalmic complications
0.000 0.101 0.899
D86.8 Sarcoidosis of other and combined sites
0.000 0.114 0.886
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.119 0.881
D59 Acquired haemolytic anaemia
0.000 0.124 0.876
E40-E46 Malnutrition
0.000 0.129 0.871
E16 Other disorders of pancreatic internal secretion
0.000 0.137 0.863
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.143 0.857
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.144 0.856
E10.5 With peripheral circulatory complications
0.000 0.144 0.856
E16.2 Hypoglycaemia, unspecified
0.000 0.161 0.839
D68 Other coagulation defects
0.000 0.164 0.836
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.165 0.835
E06.3 Autoimmune thyroiditis
0.000 0.175 0.825
E22 Hyperfunction of pituitary gland
0.000 0.178 0.822
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.811 0.189 0.000
M45.X6 Ankylosing spondylitis (Lumbar region)
0.807 0.193 0.000
G37 Other demyelinating diseases of central nervous system
0.000 0.201 0.799
E27.2 Addisonian crisis
0.000 0.202 0.798
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.202 0.798
E10.0 With coma
0.000 0.207 0.793
E27.8 Other specified disorders of adrenal gland
0.000 0.208 0.792
D69.5 Secondary thrombocytopenia
0.000 0.211 0.789
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.215 0.785
L40.1 Generalised pustular psoriasis
0.000 0.215 0.785
D86.3 Sarcoidosis of skin
0.000 0.217 0.783
E20 Hypoparathyroidism
0.000 0.220 0.780
D53 Other nutritional anaemias
0.000 0.221 0.779
D59.1 Other autoimmune haemolytic anaemias
0.000 0.221 0.779
E46 Unspecified protein-energy malnutrition
0.000 0.221 0.779
E10.8 With unspecified complications
0.000 0.221 0.779
E06.9 Thyroiditis, unspecified
0.000 0.225 0.775
E10.7 With multiple complications
0.000 0.232 0.768
D82 Immunodeficiency associated with other major defects
0.000 0.232 0.768
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.000 0.234 0.766
E14.6 With other specified complications
0.000 0.237 0.763
D68.5 Primary Thrombophilia
0.000 0.240 0.760
E53.9 Vitamin B deficiency, unspecified
0.000 0.241 0.759
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.246 0.754
D66 Hereditary factor VIII deficiency
0.000 0.252 0.748
D58 Other hereditary haemolytic anaemias
0.000 0.254 0.746
E25 Adrenogenital disorders
0.000 0.258 0.742
D69.2 Other nonthrombocytopenic purpura
0.000 0.264 0.736
L40.4 Guttate psoriasis
0.000 0.264 0.735
K90 Intestinal malabsorption
0.000 0.267 0.733
D69.6 Thrombocytopenia, unspecified
0.000 0.269 0.731
E14.2 Withrenal complications
0.000 0.271 0.729
E14.8 With unspecified complications
0.000 0.272 0.728
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.274 0.725
L40.3 Pustulosis palmaris et plantaris
0.000 0.275 0.725
E22.0 Acromegaly and pituitary gigantism
0.000 0.276 0.724
D68.2 Hereditary deficiency of other clotting factors
0.000 0.277 0.723
E31 Polyglandular dysfunction
0.000 0.282 0.718
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.282 0.718
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
D81 Combined immunodeficiencies
0.000 0.284 0.716
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.715 0.285 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.715 0.285 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.715 0.285 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.715 0.285 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.715 0.285 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.286 0.714
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.286 0.714
D51.2 Transcobalamin II deficiency
0.000 0.286 0.714
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.286 0.714
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.288 0.712
E63 Other nutritional deficiencies
0.000 0.288 0.712
E50 Vitamin A deficiency
0.000 0.288 0.712
E60 Dietary zinc deficiency
0.000 0.288 0.712
E59 Dietary selenium deficiency
0.000 0.288 0.712
E52 Niacin deficiency [pellagra]
0.000 0.288 0.712
E14.1 With ketoacidosis
0.000 0.295 0.705
E10.6 With other specified complications
0.000 0.297 0.703
E53.1 Pyridoxine deficiency
0.000 0.298 0.702
E53.0 Riboflavin deficiency
0.000 0.298 0.702
D50.1 Sideropenic dysphagia
0.000 0.302 0.698
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.302 0.697
E32 Diseases of thymus
0.000 0.302 0.697
E30 Disorders of puberty, not elsewhere classified
0.000 0.302 0.697
E27.5 Adrenomedullary hyperfunction
0.000 0.303 0.696
E27.0 Other adrenocortical overactivity
0.000 0.303 0.696
E55.0 Rickets, active
0.000 0.307 0.693
D83 Common variable immunodeficiency
0.000 0.310 0.690
E51 Thiamine deficiency
0.000 0.310 0.690
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.311 0.689
D72 Other disorders of white blood cells
0.000 0.313 0.687
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.313 0.687
E14.7 With multiple complications
0.000 0.320 0.680
E14.0 With coma
0.000 0.320 0.680
D69.4 Other primary thrombocytopenia
0.000 0.326 0.674
E14.4 With neurological complications
0.000 0.326 0.673
E14.5 With peripheral circulatory complications
0.000 0.331 0.669
E56 Other vitamin deficiencies
0.000 0.336 0.663
E54 Ascorbic acid deficiency
0.000 0.339 0.660
E06.1 Subacute thyroiditis
0.000 0.340 0.660
E15 Nondiabetic hypoglycaemic coma
0.000 0.340 0.660
D55 Anaemia due to enzyme disorders
0.000 0.341 0.659
E06.4 Drug-induced thyroiditis
0.000 0.342 0.658
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.342 0.658
E06.0 Acute thyroiditis
0.000 0.342 0.658
E22.1 Hyperprolactinaemia
0.000 0.344 0.656
D69.8 Other specified haemorrhagic conditions
0.000 0.345 0.655
E05.8 Other thyrotoxicosis
0.000 0.351 0.649
D68.1 Hereditary factor XI deficiency
0.000 0.355 0.645
E34 Other endocrine disorders
0.000 0.356 0.644
K90.9 Intestinal malabsorption, unspecified
0.000 0.357 0.643
E20.9 Hypoparathyroidism, unspecified
0.000 0.357 0.642
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.359 0.641
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.364 0.636
D69.1 Qualitative platelet defects
0.000 0.370 0.630
D59.8 Other acquired haemolytic anaemias
0.000 0.372 0.628
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.372 0.628
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.372 0.628
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.372 0.628
D59.3 Haemolytic-uraemic syndrome
0.000 0.372 0.628
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.372 0.628
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.372 0.628
D72.8 Other specified disorders of white blood cells
0.000 0.373 0.627
E58 Dietary calcium deficiency
0.000 0.373 0.627
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.375 0.624
E45 Retarded development following protein-energy malnutrition
0.000 0.375 0.624
E43 Unspecified severe protein-energy malnutrition
0.000 0.375 0.624
E42 Marasmic kwashiorkor
0.000 0.375 0.624
E41 Nutritional marasmus
0.000 0.375 0.624
E40 Kwashiorkor
0.000 0.375 0.624
D84 Other immunodeficiencies
0.000 0.376 0.624
D53.9 Nutritional anaemia, unspecified
0.000 0.378 0.622
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.381 0.619
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.381 0.619
E16.4 Abnormal secretion of gastrin
0.000 0.381 0.619
E16.3 Increased secretion of glucagon
0.000 0.381 0.619
D70 Agranulocytosis
0.000 0.382 0.618
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.383 0.617
E06.5 Other chronic thyroiditis
0.000 0.383 0.617
E23 Hypofunction and other disorders of pituitary gland
0.000 0.386 0.614
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.395 0.605
D58.0 Hereditary spherocytosis
0.000 0.396 0.604
E13 Other specified diabetes mellitus
0.000 0.397 0.603
D67 Hereditary factor IX deficiency
0.000 0.397 0.602
E29 Testicular dysfunction
0.000 0.398 0.602
D82.1 Di George's syndrome
0.000 0.398 0.602
D75 Other diseases of blood and blood-forming organs
0.000 0.399 0.601
D69.9 Haemorrhagic condition, unspecified
0.000 0.402 0.598
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.410 0.589
E22.8 Other hyperfunction of pituitary gland
0.000 0.410 0.589
D57 Sickle-cell disorders
0.000 0.415 0.585
D52 Folate deficiency anaemia
0.000 0.418 0.581
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.423 0.577
G37.5 Concentric sclerosis [Balo]
0.000 0.427 0.573
G37.4 Subacute necrotising myelitis
0.000 0.427 0.573
G37.2 Central pontine myelinolysis
0.000 0.427 0.573
G37.1 Central demyelination of corpus callosum
0.000 0.427 0.573
G37.0 Diffuse sclerosis
0.000 0.427 0.573
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.431 0.569
D74 Methaemoglobinaemia
0.000 0.437 0.563
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.437 0.563
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.437 0.563
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.438 0.562
E20.8 Other hypoparathyroidism
0.000 0.440 0.560
E20.1 Pseudohypoparathyroidism
0.000 0.440 0.560
E20.0 Idiopathic hypoparathyroidism
0.000 0.440 0.560
D53.8 Other specified nutritional anaemias
0.000 0.441 0.559
D53.2 Scorbutic anaemia
0.000 0.441 0.559
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.441 0.559
D53.0 Protein deficiency anaemia
0.000 0.441 0.559
E11 Non-insulin-dependent diabetes mellitus
0.000 0.441 0.559
G36 Other acute disseminated demyelination
0.000 0.445 0.555
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.445 0.555
D68.4 Acquired coagulation factor deficiency
0.000 0.446 0.554
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.450 0.550
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.450 0.550
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.450 0.550
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.450 0.550
D82.2 Immunodeficiency with short-limbed stature
0.000 0.450 0.550
D82.0 Wiskott-Aldrich syndrome
0.000 0.450 0.550
E31.0 Autoimmune polyglandular failure
0.000 0.464 0.536
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.465 0.535
D58.1 Hereditary elliptocytosis
0.000 0.465 0.535
E25.9 Adrenogenital disorder, unspecified
0.000 0.468 0.532
E25.8 Other adrenogenital disorders
0.000 0.468 0.532
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.468 0.532
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.471 0.529
D58.2 Other haemoglobinopathies
0.000 0.474 0.526
K90.3 Pancreatic steatorrhoea
0.000 0.474 0.526
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.474 0.526
K90.1 Tropical sprue
0.000 0.474 0.526
D68.6 Other Thrombophilia
0.000 0.476 0.524
E31.9 Polyglandular dysfunction, unspecified
0.000 0.485 0.515
E31.8 Other polyglandular dysfunction
0.000 0.485 0.515
E31.1 Polyglandular hyperfunction
0.000 0.485 0.515
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
D56 Thalassaemia
0.000 0.486 0.513
D81.9 Combined immunodeficiency, unspecified
0.000 0.486 0.514
D81.8 Other combined immunodeficiencies
0.000 0.486 0.514
D81.7 Major histocompatibility complex class II deficiency
0.000 0.486 0.514
D81.6 Major histocompatibility complex class I deficiency
0.000 0.486 0.514
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.486 0.514
D81.4 Nezelof's syndrome
0.000 0.486 0.514
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.486 0.514
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.486 0.514
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.486 0.514
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.486 0.514
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.489 0.511
E23.7 Disorder of pituitary gland, unspecified
0.000 0.489 0.511
E50.9 Vitamin A deficiency, unspecified
0.000 0.489 0.511
E50.8 Other manifestations of vitamin A deficiency
0.000 0.489 0.511
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.489 0.511
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.489 0.511
E50.5 Vitamin A deficiency with night blindness
0.000 0.489 0.511
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.489 0.511
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.489 0.511
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.489 0.511
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.489 0.511
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.489 0.511
E63.9 Nutritional deficiency, unspecified
0.000 0.489 0.511
E63.8 Other specified nutritional deficiencies
0.000 0.489 0.511
E63.1 Imbalance of constituents of food intake
0.000 0.489 0.511
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.489 0.511
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.489 0.511
E64.8 Sequelae of other nutritional deficiencies
0.000 0.489 0.511
E64.3 Sequelae of rickets
0.000 0.489 0.511
E64.2 Sequelae of vitamin C deficiency
0.000 0.489 0.511
E64.1 Sequelae of vitamin A deficiency
0.000 0.489 0.511
E64.0 Sequelae of protein-energy malnutrition
0.000 0.489 0.511
L40.8 Other psoriasis
0.000 0.492 0.508
E11.1 With ketoacidosis
0.000 0.493 0.507
E24 Cushing's syndrome
0.000 0.493 0.507
E14.9 Without complications
0.000 0.498 0.502
K90.8 Other intestinal malabsorption
0.000 0.499 0.501
E30.9 Disorder of puberty, unspecified
0.000 0.500 0.500
E30.8 Other disorders of puberty
0.000 0.500 0.500
E30.1 Precocious puberty
0.000 0.500 0.500
E30.0 Delayed puberty
0.000 0.500 0.500
E32.9 Disease of thymus, unspecified
0.000 0.500 0.500
E32.8 Other diseases of thymus
0.000 0.500 0.500
E32.1 Abscess of thymus
0.000 0.500 0.500
E32.0 Persistent hyperplasia of thymus
0.000 0.500 0.500
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.500 0.500
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.500 0.500
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.500 0.500
E34.9 Endocrine disorder, unspecified
0.000 0.505 0.495
D83.8 Other common variable immunodeficiencies
0.000 0.505 0.495
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.505 0.495
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.505 0.495
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.505 0.495
E51.9 Thiamine deficiency, unspecified
0.000 0.505 0.495
E51.8 Other manifestations of thiamine deficiency
0.000 0.505 0.495
E51.1 Beriberi
0.000 0.505 0.495
E61 Deficiency of other nutrient elements
0.000 0.507 0.493
D72.9 Disorder of white blood cells, unspecified
0.000 0.507 0.493
D72.0 Genetic anomalies of leukocytes
0.000 0.507 0.493
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.508 0.492
E16.1 Other hypoglycaemia
0.000 0.522 0.477
E56.9 Vitamin deficiency, unspecified
0.000 0.524 0.476
E56.8 Deficiency of other vitamins
0.000 0.524 0.476
E56.0 Deficiency of vitamin E
0.000 0.524 0.476
D84.1 Defects in the complement system
0.000 0.527 0.473
E51.2 Wernicke's encephalopathy
0.000 0.527 0.473
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.527 0.473
D55.8 Other anaemias due to enzyme disorders
0.000 0.527 0.473
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.527 0.473
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.527 0.473
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.527 0.473
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.527 0.473
D83.9 Common variable immunodeficiency, unspecified
0.000 0.531 0.468
E07 Other disorders of thyroid
0.002 0.533 0.465
E34.0 Carcinoid syndrome
0.000 0.535 0.465
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.537 0.463
E34.5 Androgen resistance syndrome
0.000 0.538 0.462
E34.4 Constitutional tall stature
0.000 0.538 0.462
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.538 0.462
E34.1 Other hypersecretion of intestinal hormones
0.000 0.538 0.462
E26 Hyperaldosteronism
0.001 0.541 0.459
D72.1 Eosinophilia
0.000 0.542 0.458
E11.3 With ophthalmic complications
0.000 0.543 0.457
D89.3 Immune reconstitution syndrome
0.000 0.544 0.456
E27.9 Disorder of adrenal gland, unspecified
0.000 0.546 0.453
D75.0 Familial erythrocytosis
0.000 0.547 0.453
E44.1 Mild protein-energy malnutrition
0.000 0.552 0.448
E44.0 Moderate protein-energy malnutrition
0.000 0.552 0.448
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.553 0.447
E28 Ovarian dysfunction
0.000 0.554 0.445
D84.8 Other specified immunodeficiencies
0.000 0.557 0.442
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.559 0.440
E23.1 Drug-induced hypopituitarism
0.000 0.559 0.440
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.563 0.437
E11.8 With unspecified complications
0.000 0.564 0.436
E03 Other hypothyroidism
0.005 0.564 0.432
E11.5 With peripheral circulatory complications
0.000 0.565 0.435
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.567 0.433
D75.1 Secondary polycythaemia
0.000 0.568 0.432
E13.8 With unspecified complications
0.000 0.568 0.432
E13.7 With multiple complications
0.000 0.568 0.432
E13.6 With other specified complications
0.000 0.568 0.432
E13.5 With peripheral circulatory complications
0.000 0.568 0.432
E13.4 With neurological complications
0.000 0.568 0.432
E13.3 With ophthalmic complications
0.000 0.568 0.432
E13.2 With renal complications
0.000 0.568 0.432
E13.1 With ketoacidosis
0.000 0.568 0.432
E13.0 With coma
0.000 0.568 0.432
E29.9 Testicular dysfunction, unspecified
0.000 0.568 0.432
E29.8 Other testicular dysfunction
0.000 0.568 0.432
E29.0 Testicular hyperfunction
0.000 0.568 0.432
E23.6 Other disorders of pituitary gland
0.000 0.570 0.430
D89.1 Cryoglobulinaemia
0.000 0.571 0.429
M45-M49 Spondylopathies
0.428 0.572 0.000
E56.1 Deficiency of vitamin K
0.000 0.573 0.427
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.574 0.426
D57.8 Other sickle-cell disorders
0.000 0.580 0.420
D57.3 Sickle-cell trait
0.000 0.580 0.420
D57.2 Double heterozygous sickling disorders
0.000 0.580 0.420
D57.0 Sickle-cell anaemia with crisis
0.000 0.580 0.420
D52.8 Other folate deficiency anaemias
0.000 0.583 0.417
D52.1 Drug-induced folate deficiency anaemia
0.000 0.583 0.417
D52.0 Dietary folate deficiency anaemia
0.000 0.583 0.417
E34.8 Other specified endocrine disorders
0.000 0.585 0.415
D68.8 Other specified coagulation defects
0.000 0.590 0.409
E34.3 Short stature, not elsewhere classified
0.000 0.591 0.409
D74.9 Methaemoglobinaemia, unspecified
0.000 0.596 0.404
D74.8 Other methaemoglobinaemias
0.000 0.596 0.404
D74.0 Congenital methaemoglobinaemia
0.000 0.596 0.404
D80 Immunodeficiency with predominantly antibody defects
0.001 0.598 0.401
G36.9 Acute disseminated demyelination, unspecified
0.000 0.602 0.398
G36.8 Other specified acute disseminated demyelination
0.000 0.602 0.398
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.602 0.398
E24.0 Pituitary-dependent Cushing's disease
0.000 0.608 0.392
E65-E68 Obesity and other hyperalimentation
0.000 0.614 0.386
D68.0 Von Willebrand's disease
0.000 0.616 0.384
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.620 0.380
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.621 0.379
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.621 0.379
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.621 0.379
D69.0 Allergic purpura
0.001 0.621 0.379
E11.7 With multiple complications
0.000 0.621 0.379
D68.9 Coagulation defect, unspecified
0.000 0.624 0.376
M46 Other inflammatory spondylopathies
0.372 0.628 0.000
D60-D64 Aplastic and other anaemias
0.000 0.628 0.372
D56.9 Thalassaemia, unspecified
0.000 0.631 0.368
D56.8 Other thalassaemias
0.000 0.631 0.368
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.000 0.631 0.368
D56.2 Delta-beta thalassaemia
0.000 0.631 0.368
D56.0 Alpha thalassaemia
0.000 0.631 0.368
E03.8 Other specified hypothyroidism
0.002 0.633 0.365
M48 Other spondylopathies
0.365 0.635 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.636 0.363
E24.3 Ectopic ACTH syndrome
0.000 0.636 0.363
E24.1 Nelson's syndrome
0.000 0.636 0.363
D75.2 Essential thrombocytosis
0.000 0.639 0.361
E23.2 Diabetes insipidus
0.000 0.642 0.358
E04 Other non-toxic goitre
0.000 0.645 0.355
G36.0 Neuromyelitis optica [Devic]
0.000 0.646 0.354
E61.9 Deficiency of nutrient element, unspecified
0.000 0.646 0.353
E61.8 Deficiency of other specified nutrient elements
0.000 0.646 0.353
E61.7 Deficiency of multiple nutrient elements
0.000 0.646 0.353
E61.6 Vanadium deficiency
0.000 0.646 0.353
E61.5 Molybdenum deficiency
0.000 0.646 0.353
E61.4 Chromium deficiency
0.000 0.646 0.353
E61.3 Manganese deficiency
0.000 0.646 0.353
E61.0 Copper deficiency
0.000 0.646 0.353
L40-L45 Papulosquamous disorders
0.000 0.647 0.353
E07.8 Other specified disorders of thyroid
0.001 0.649 0.349
E11.4 With neurological complications
0.000 0.650 0.350
E11.0 With coma
0.000 0.653 0.346
D57.1 Sickle-cell anaemia without crisis
0.001 0.654 0.345
D76.3 Other histiocytosis syndromes
0.000 0.655 0.345
E11.6 With other specified complications
0.000 0.656 0.343
E24.8 Other Cushing's syndrome
0.000 0.661 0.339
E23.0 Hypopituitarism
0.000 0.661 0.339
E29.1 Testicular hypofunction
0.000 0.664 0.336
E07.1 Dyshormogenetic goitre
0.001 0.665 0.334
E07.0 Hypersecretion of calcitonin
0.001 0.665 0.334
D50.8 Other iron deficiency anaemias
0.000 0.667 0.333
E26.8 Other hyperaldosteronism
0.001 0.670 0.329
E26.1 Secondary hyperaldosteronism
0.001 0.670 0.329
E04.0 Non-toxic diffuse goitre
0.000 0.677 0.323
M48.0 Spinal stenosis
0.322 0.678 0.000
M46.9 Inflammatory spondylopathy, unspecified
0.322 0.678 0.000
E28.9 Ovarian dysfunction, unspecified
0.000 0.680 0.319
E28.8 Other ovarian dysfunction
0.000 0.680 0.319
E28.1 Androgen excess
0.000 0.680 0.319
E28.0 Oestrogen excess
0.000 0.680 0.319
E13.9 Without complications
0.000 0.682 0.318
D84.9 Immunodeficiency, unspecified
0.001 0.684 0.316
E61.2 Magnesium deficiency
0.000 0.684 0.316
D56.3 Thalassaemia trait
0.000 0.684 0.316
E03.0 Congenital hypothyroidism with diffuse goitre
0.003 0.686 0.311
M46.4 Discitis, unspecified
0.313 0.686 0.000
E03.5 Myxoedema coma
0.003 0.687 0.309
E03.4 Atrophy of thyroid (acquired)
0.003 0.687 0.309
E03.3 Postinfectious hypothyroidism
0.003 0.687 0.309
E28.3 Primary ovarian failure
0.000 0.687 0.312
E24.2 Drug-induced Cushing's syndrome
0.000 0.688 0.312
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.691 0.309
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)
0.308 0.692 0.000
E03.1 Congenital hypothyroidism without goitre
0.003 0.693 0.304
M48.02 Spinal stenosis (Cervical region)
0.307 0.693 0.000
D64 Other anaemias
0.000 0.693 0.307
D73 Diseases of spleen
0.000 0.694 0.306
D56.1 Beta thalassaemia
0.001 0.700 0.300
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.703 0.297
D80.8 Other immunodeficiencies with predominantly antibody defects
0.001 0.712 0.288
D80.7 Transient hypogammaglobulinaemia of infancy
0.001 0.712 0.288
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.001 0.712 0.288
D80.0 Hereditary hypogammaglobulinaemia
0.001 0.712 0.288
D52.9 Folate deficiency anaemia, unspecified
0.000 0.718 0.282
M48.08 Spinal stenosis (Sacral and sacrococcygeal region)
0.280 0.720 0.000
M48.09 Spinal stenosis (Site unspecified)
0.277 0.723 0.000
E67 Other hyperalimentation
0.000 0.723 0.277
E68 Sequelae of hyperalimentation
0.000 0.723 0.277
K90-K93 Other diseases of the digestive system
0.000 0.724 0.276
M46.2 Osteomyelitis of vertebra
0.274 0.726 0.000
M49 Spondylopathies in diseases classified elsewhere
0.274 0.726 0.000
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.726 0.274
M46.46 Discitis, unspecified (Lumbar region)
0.274 0.726 0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.001 0.727 0.272
E26.9 Hyperaldosteronism, unspecified
0.001 0.729 0.271
M48.9 Spondylopathy, unspecified
0.269 0.731 0.000
M46.8 Other specified inflammatory spondylopathies
0.267 0.733 0.000
M46.5 Other infective spondylopathies
0.267 0.733 0.000
M46.0 Spinal enthesopathy
0.265 0.735 0.000
M48.4 Fatigue fracture of vertebra
0.262 0.738 0.000
M48.3 Traumatic spondylopathy
0.262 0.738 0.000
M48.2 Kissing spine
0.262 0.738 0.000
M48.1 Ankylosing hyperostosis [Forestier]
0.262 0.738 0.000
M48.8 Other specified spondylopathies
0.262 0.738 0.000
D61 Other aplastic anaemias
0.000 0.744 0.256
E04.8 Other specified non-toxic goitre
0.000 0.745 0.255
L44 Other papulosquamous disorders
0.000 0.746 0.253
L41 Parapsoriasis
0.000 0.746 0.253

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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