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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3095227
log Bayes Factor = 47.3464
Chromosome 6   position 31,491,000  (GRCh37) Explore rs3095227 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.004 0.996
E05.9 Thyrotoxicosis, unspecified
0.000 0.005 0.995
E11 Non-insulin-dependent diabetes mellitus
0.000 0.007 0.993
E00-E07 Disorders of thyroid gland
0.000 0.007 0.993
E11.9 Without complications
0.000 0.009 0.991
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.011 0.989
E14.3 With ophthalmic complications
0.000 0.013 0.987
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.019 0.981
E10.1 With ketoacidosis
0.000 0.020 0.980
E10.4 With neurological complications
0.000 0.028 0.972
E14.9 Without complications
0.000 0.032 0.968
E03 Other hypothyroidism
0.000 0.059 0.941
E03.9 Hypothyroidism, unspecified
0.000 0.068 0.932
E10.2 With renal complications
0.000 0.072 0.928
E11.0 With coma
0.000 0.075 0.925
J45.9 Asthma, unspecified
0.000 0.091 0.909
E14.8 With unspecified complications
0.000 0.155 0.845
E83.1 Disorders of iron metabolism
0.830 0.170 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.180 0.820
E13 Other specified diabetes mellitus
0.000 0.188 0.812
E10.8 With unspecified complications
0.000 0.193 0.807
G35-G37 Demyelinating diseases of the central nervous system
0.800 0.200 0.000
E10.0 With coma
0.000 0.205 0.795
E07 Other disorders of thyroid
0.000 0.213 0.787
E10.5 With peripheral circulatory complications
0.000 0.216 0.784
E14.6 With other specified complications
0.000 0.234 0.766
E11.5 With peripheral circulatory complications
0.000 0.238 0.762
G37 Other demyelinating diseases of central nervous system
0.759 0.241 0.000
E14.5 With peripheral circulatory complications
0.000 0.255 0.745
E06 Thyroiditis
0.000 0.256 0.744
E14.4 With neurological complications
0.000 0.260 0.740
E14.1 With ketoacidosis
0.000 0.263 0.737
M06.9 Rheumatoid arthritis, unspecified
0.000 0.263 0.737
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.267 0.733
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.276 0.724
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.716
E14.2 Withrenal complications
0.000 0.283 0.716
E14.0 With coma
0.000 0.283 0.716
E05.5 Thyroid crisis or storm
0.000 0.286 0.714
E05.4 Thyrotoxicosis factitia
0.000 0.286 0.714
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.286 0.714
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.286 0.714
E11.2 With renal complications
0.000 0.287 0.713
E11.7 With multiple complications
0.000 0.288 0.712
G37.9 Demyelinating disease of central nervous system, unspecified
0.712 0.288 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.288 0.712
E00 Congenital iodine-deficiency syndrome
0.000 0.288 0.712
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.290 0.710
E16 Other disorders of pancreatic internal secretion
0.000 0.301 0.699
E10.6 With other specified complications
0.000 0.307 0.693
E13.9 Without complications
0.000 0.311 0.688
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.314 0.686
E11.1 With ketoacidosis
0.000 0.315 0.685
E11.6 With other specified complications
0.000 0.320 0.680
E03.5 Myxoedema coma
0.000 0.325 0.675
E03.4 Atrophy of thyroid (acquired)
0.000 0.325 0.675
E03.3 Postinfectious hypothyroidism
0.000 0.325 0.675
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.326 0.674
E05.8 Other thyrotoxicosis
0.000 0.327 0.673
E07.9 Disorder of thyroid, unspecified
0.000 0.338 0.662
E03.1 Congenital hypothyroidism without goitre
0.000 0.339 0.661
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.361 0.638
K90 Intestinal malabsorption
0.000 0.362 0.638
G37.8 Other specified demyelinating diseases of central nervous system
0.637 0.363 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.377 0.623
M45 Ankylosing spondylitis
0.000 0.387 0.613
E65-E68 Obesity and other hyperalimentation
0.000 0.393 0.607
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.393 0.607
E06.9 Thyroiditis, unspecified
0.000 0.395 0.605
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.399 0.601
E15 Nondiabetic hypoglycaemic coma
0.000 0.412 0.588
E16.2 Hypoglycaemia, unspecified
0.000 0.413 0.587
K90.9 Intestinal malabsorption, unspecified
0.000 0.416 0.584
E13.8 With unspecified complications
0.000 0.418 0.582
E13.7 With multiple complications
0.000 0.418 0.582
E13.6 With other specified complications
0.000 0.418 0.582
E13.5 With peripheral circulatory complications
0.000 0.418 0.582
E13.4 With neurological complications
0.000 0.418 0.582
E13.2 With renal complications
0.000 0.418 0.582
E13.1 With ketoacidosis
0.000 0.418 0.582
E13.0 With coma
0.000 0.418 0.582
E40-E46 Malnutrition
0.000 0.424 0.576
G36 Other acute disseminated demyelination
0.575 0.425 0.000
E11.8 With unspecified complications
0.000 0.425 0.575
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.433 0.567
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.436 0.564
E07.1 Dyshormogenetic goitre
0.000 0.436 0.564
E07.0 Hypersecretion of calcitonin
0.000 0.436 0.564
E13.3 With ophthalmic complications
0.000 0.440 0.559
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.441 0.559
G37.5 Concentric sclerosis [Balo]
0.544 0.456 0.000
G37.4 Subacute necrotising myelitis
0.544 0.456 0.000
G37.2 Central pontine myelinolysis
0.544 0.456 0.000
G37.1 Central demyelination of corpus callosum
0.544 0.456 0.000
G37.0 Diffuse sclerosis
0.544 0.456 0.000
E16.1 Other hypoglycaemia
0.000 0.458 0.542
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.460 0.540
E06.5 Other chronic thyroiditis
0.000 0.466 0.533
E06.4 Drug-induced thyroiditis
0.000 0.466 0.533
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.466 0.533
E06.1 Subacute thyroiditis
0.000 0.466 0.533
E06.0 Acute thyroiditis
0.000 0.466 0.533
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.475 0.525
E07.8 Other specified disorders of thyroid
0.000 0.477 0.523
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.477 0.523
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.521 0.478 0.000
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.489 0.510
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.489 0.510
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.489 0.510
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.489 0.510
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.489 0.510
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.489 0.510
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.489 0.510
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.489 0.510
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.496 0.504
E65 Localised adiposity
0.000 0.498 0.502
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.499 0.501
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.499 0.501
E16.4 Abnormal secretion of gastrin
0.000 0.499 0.501
E16.3 Increased secretion of glucagon
0.000 0.499 0.501
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.520 0.480
E06.3 Autoimmune thyroiditis
0.000 0.526 0.474
K90.8 Other intestinal malabsorption
0.000 0.532 0.468
K90.3 Pancreatic steatorrhoea
0.000 0.543 0.457
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.543 0.457
K90.1 Tropical sprue
0.000 0.543 0.457
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.550 0.450
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.560 0.440
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.560 0.440
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.560 0.440
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.560 0.440
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.560 0.440
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.560 0.440
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.560 0.440
E67 Other hyperalimentation
0.000 0.565 0.435
E68 Sequelae of hyperalimentation
0.000 0.565 0.435
E50-E64 Other nutritional deficiencies
0.000 0.575 0.425
G36.0 Neuromyelitis optica [Devic]
0.414 0.586 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.587 0.413
E45 Retarded development following protein-energy malnutrition
0.000 0.587 0.413
E43 Unspecified severe protein-energy malnutrition
0.000 0.587 0.413
E42 Marasmic kwashiorkor
0.000 0.587 0.413
E41 Nutritional marasmus
0.000 0.587 0.413
E40 Kwashiorkor
0.000 0.587 0.413
G36.9 Acute disseminated demyelination, unspecified
0.412 0.587 0.000
G36.8 Other specified acute disseminated demyelination
0.412 0.587 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.412 0.587 0.000
E11.4 With neurological complications
0.000 0.590 0.410
M06 Other rheumatoid arthritis
0.000 0.608 0.392
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.645 0.355
E03.8 Other specified hypothyroidism
0.001 0.649 0.350
M06.4 Inflammatory polyarthropathy
0.000 0.669 0.331
R07.4 Chest pain, unspecified
0.000 0.671 0.329
E20-E35 Disorders of other endocrine glands
0.000 0.674 0.326
E51 Thiamine deficiency
0.000 0.676 0.324
E67.8 Other specified hyperalimentation
0.000 0.688 0.312
E67.3 Hypervitaminosis D
0.000 0.688 0.312
E67.2 Megavitamin-B6 syndrome
0.000 0.688 0.312
E67.1 Hypercarotenaemia
0.000 0.688 0.312
E67.0 Hypervitaminosis A
0.000 0.688 0.312
E58 Dietary calcium deficiency
0.000 0.688 0.312
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.695 0.305
E63 Other nutritional deficiencies
0.000 0.695 0.305
E50 Vitamin A deficiency
0.000 0.695 0.305
E60 Dietary zinc deficiency
0.000 0.695 0.305
E59 Dietary selenium deficiency
0.000 0.695 0.305
E54 Ascorbic acid deficiency
0.000 0.695 0.305
E52 Niacin deficiency [pellagra]
0.000 0.695 0.305
M06.3 Rheumatoid nodule
0.000 0.697 0.303
E56 Other vitamin deficiencies
0.000 0.698 0.302
E44.1 Mild protein-energy malnutrition
0.000 0.703 0.296
E44.0 Moderate protein-energy malnutrition
0.000 0.703 0.296
E22 Hyperfunction of pituitary gland
0.000 0.712 0.288
M06.8 Other specified rheumatoid arthritis
0.000 0.719 0.281
M06.2 Rheumatoid bursitis
0.000 0.719 0.281
M06.1 Adult-onset Still's disease
0.000 0.719 0.281
E46 Unspecified protein-energy malnutrition
0.000 0.719 0.280
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.726 0.274
E61 Deficiency of other nutrient elements
0.000 0.730 0.270
E29 Testicular dysfunction
0.000 0.736 0.264
M06.34 Rheumatoid nodule (Hand)
0.000 0.738 0.262
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.740 0.260
E55 Vitamin D deficiency
0.000 0.744 0.256
E22.1 Hyperprolactinaemia
0.000 0.748 0.252
E51.2 Wernicke's encephalopathy
0.000 0.749 0.251
E23 Hypofunction and other disorders of pituitary gland
0.000 0.758 0.242
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.762 0.238
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.762 0.238
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.762 0.238
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.762 0.238
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.762 0.238
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.762 0.238
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.762 0.238
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.762 0.238
E25 Adrenogenital disorders
0.000 0.763 0.237
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.764 0.236
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.766 0.234
E32 Diseases of thymus
0.000 0.766 0.234
E31 Polyglandular dysfunction
0.000 0.766 0.234
E30 Disorders of puberty, not elsewhere classified
0.000 0.766 0.234
E51.9 Thiamine deficiency, unspecified
0.000 0.768 0.232
E51.8 Other manifestations of thiamine deficiency
0.000 0.768 0.232
E51.1 Beriberi
0.000 0.768 0.232
E70-E90 Metabolic disorders
0.003 0.768 0.229
E83 Disorders of mineral metabolism
0.197 0.771 0.032
M06.0 Seronegative rheumatoid arthritis
0.000 0.780 0.220
E29.1 Testicular hypofunction
0.000 0.780 0.220
E50.9 Vitamin A deficiency, unspecified
0.000 0.781 0.219
E50.8 Other manifestations of vitamin A deficiency
0.000 0.781 0.219
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.781 0.219
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.781 0.219
E50.5 Vitamin A deficiency with night blindness
0.000 0.781 0.219
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.781 0.219
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.781 0.219
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.781 0.219
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.781 0.219
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.781 0.219
E63.9 Nutritional deficiency, unspecified
0.000 0.781 0.219
E63.8 Other specified nutritional deficiencies
0.000 0.781 0.219
E63.1 Imbalance of constituents of food intake
0.000 0.781 0.219
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.781 0.219
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.781 0.219
E64.8 Sequelae of other nutritional deficiencies
0.000 0.781 0.219
E64.3 Sequelae of rickets
0.000 0.781 0.219
E64.2 Sequelae of vitamin C deficiency
0.000 0.781 0.219
E64.1 Sequelae of vitamin A deficiency
0.000 0.781 0.219
E64.0 Sequelae of protein-energy malnutrition
0.000 0.781 0.219
E24 Cushing's syndrome
0.000 0.782 0.218
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.782 0.217
M06.38 Rheumatoid nodule (Other)
0.000 0.782 0.217
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.782 0.217
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.782 0.217
M06.33 Rheumatoid nodule (Forearm)
0.000 0.782 0.217
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.782 0.217
E56.9 Vitamin deficiency, unspecified
0.000 0.783 0.216
E56.8 Deficiency of other vitamins
0.000 0.783 0.216
E56.0 Deficiency of vitamin E
0.000 0.783 0.216
E20 Hypoparathyroidism
0.000 0.785 0.215
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.785 0.215
E56.1 Deficiency of vitamin K
0.000 0.787 0.213
J45 Asthma
0.000 0.789 0.211
E26 Hyperaldosteronism
0.000 0.790 0.210
E85 Amyloidosis
0.001 0.790 0.209
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.791 0.209
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.793 0.207
E22.8 Other hyperfunction of pituitary gland
0.000 0.793 0.207
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.794 0.205
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.798 0.202
M06.18 Adult-onset Still's disease (Other)
0.000 0.798 0.202
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.798 0.202
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.798 0.202
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.798 0.202
M06.14 Adult-onset Still's disease (Hand)
0.000 0.798 0.202
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.798 0.202
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.798 0.202
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.798 0.202
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.798 0.202
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.798 0.202
M06.28 Rheumatoid bursitis (Other)
0.000 0.798 0.202
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.798 0.202
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.798 0.202
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.798 0.202
M06.24 Rheumatoid bursitis (Hand)
0.000 0.798 0.202
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.798 0.202
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.798 0.202
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.798 0.202
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.798 0.202
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.798 0.202
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.798 0.202
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.798 0.202
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.798 0.202
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.798 0.202
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.798 0.202
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.798 0.202
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.798 0.202
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.798 0.202
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.798 0.202
E23.2 Diabetes insipidus
0.000 0.801 0.199
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.804 0.196
E61.9 Deficiency of nutrient element, unspecified
0.000 0.806 0.193
E61.8 Deficiency of other specified nutrient elements
0.000 0.806 0.193
E61.7 Deficiency of multiple nutrient elements
0.000 0.806 0.193
E61.6 Vanadium deficiency
0.000 0.806 0.193
E61.5 Molybdenum deficiency
0.000 0.806 0.193
E61.4 Chromium deficiency
0.000 0.806 0.193
E61.3 Manganese deficiency
0.000 0.806 0.193
E61.0 Copper deficiency
0.000 0.806 0.193
E78.2 Mixed hyperlipidaemia
0.000 0.807 0.193
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.808 0.192
E22.0 Acromegaly and pituitary gigantism
0.000 0.808 0.192
E23.6 Other disorders of pituitary gland
0.000 0.808 0.192
E29.9 Testicular dysfunction, unspecified
0.000 0.810 0.189
E29.8 Other testicular dysfunction
0.000 0.810 0.189
E29.0 Testicular hyperfunction
0.000 0.810 0.189
E61.2 Magnesium deficiency
0.000 0.813 0.187
E85.9 Amyloidosis, unspecified
0.000 0.813 0.186
E11.3 With ophthalmic complications
0.000 0.813 0.187
E55.0 Rickets, active
0.000 0.816 0.183
E24.2 Drug-induced Cushing's syndrome
0.000 0.817 0.183
E78.0 Pure hypercholesterolaemia
0.000 0.817 0.183
E79 Disorders of purine and pyrimidine metabolism
0.002 0.821 0.177
E34 Other endocrine disorders
0.000 0.822 0.178
E83.3 Disorders of phosphorus metabolism
0.169 0.822 0.009
E78.8 Other disorders of lipoprotein metabolism
0.000 0.824 0.176
E78.5 Hyperlipidaemia, unspecified
0.000 0.826 0.174
E28 Ovarian dysfunction
0.000 0.826 0.174
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.826 0.174
E23.1 Drug-induced hypopituitarism
0.000 0.826 0.174
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.827 0.173
E25.9 Adrenogenital disorder, unspecified
0.000 0.830 0.170
E25.8 Other adrenogenital disorders
0.000 0.830 0.170
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.830 0.170
E89.3 Postprocedural hypopituitarism
0.000 0.831 0.169
E30.9 Disorder of puberty, unspecified
0.000 0.832 0.168
E30.8 Other disorders of puberty
0.000 0.832 0.168
E30.1 Precocious puberty
0.000 0.832 0.168
E30.0 Delayed puberty
0.000 0.832 0.168
E31.9 Polyglandular dysfunction, unspecified
0.000 0.832 0.168
E31.8 Other polyglandular dysfunction
0.000 0.832 0.168
E31.1 Polyglandular hyperfunction
0.000 0.832 0.168
E31.0 Autoimmune polyglandular failure
0.000 0.832 0.168
E32.9 Disease of thymus, unspecified
0.000 0.832 0.168
E32.8 Other diseases of thymus
0.000 0.832 0.168
E32.1 Abscess of thymus
0.000 0.832 0.168
E32.0 Persistent hyperplasia of thymus
0.000 0.832 0.168
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.832 0.168
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.832 0.168
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.832 0.168
E61.1 Iron deficiency
0.000 0.834 0.166
E77 Disorders of glycoprotein metabolism
0.002 0.834 0.164
E76 Disorders of glycosaminoglycan metabolism
0.002 0.834 0.164
E72 Other disorders of amino-acid metabolism
0.002 0.834 0.164
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.002 0.834 0.164
E70 Disorders of aromatic amino-acid metabolism
0.002 0.834 0.164
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.002 0.834 0.164
E23.7 Disorder of pituitary gland, unspecified
0.000 0.834 0.166
E85.4 Organ-limited amyloidosis
0.001 0.835 0.165
E83.9 Disorder of mineral metabolism, unspecified
0.141 0.836 0.023
E83.8 Other disorders of mineral metabolism
0.141 0.836 0.023
E83.2 Disorders of zinc metabolism
0.141 0.836 0.023
E83.0 Disorders of copper metabolism
0.141 0.836 0.023
E66 Obesity
0.000 0.838 0.162
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.838 0.162
E85.3 Secondary systemic amyloidosis
0.001 0.840 0.159
L40.9 Psoriasis, unspecified
0.159 0.841 0.000
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.842 0.158
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.842 0.158
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.842 0.158
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.842 0.158
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.842 0.158
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.842 0.158
E78.6 Lipoprotein deficiency
0.000 0.842 0.158
E24.8 Other Cushing's syndrome
0.000 0.843 0.157
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.843 0.157
E24.3 Ectopic ACTH syndrome
0.000 0.843 0.157
E24.1 Nelson's syndrome
0.000 0.843 0.157
E78.1 Pure hyperglyceridaemia
0.000 0.844 0.155
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.845 0.155
E20.8 Other hypoparathyroidism
0.000 0.845 0.154
E20.1 Pseudohypoparathyroidism
0.000 0.845 0.154
E20.0 Idiopathic hypoparathyroidism
0.000 0.845 0.154
E78.3 Hyperchylomicronaemia
0.000 0.846 0.154
J45.8 Mixed asthma
0.000 0.847 0.153
E53 Deficiency of other B group vitamins
0.000 0.848 0.152
E74 Other disorders of carbohydrate metabolism
0.002 0.848 0.150
J45.1 Nonallergic asthma
0.000 0.849 0.151
E26.9 Hyperaldosteronism, unspecified
0.000 0.849 0.151
E26.8 Other hyperaldosteronism
0.000 0.849 0.151
E26.1 Secondary hyperaldosteronism
0.000 0.849 0.151
E85.8 Other amyloidosis
0.001 0.849 0.150
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.849 0.150
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.849 0.150
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.849 0.150
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.850 0.150
E84 Cystic fibrosis
0.002 0.854 0.144
E73 Lactose intolerance
0.002 0.854 0.144
E78.4 Other hyperlipidaemia
0.000 0.854 0.146
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.002 0.856 0.142
E04 Other non-toxic goitre
0.000 0.858 0.142
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.859 0.139
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.862 0.138
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.862 0.138
E89.5 Postprocedural testicular hypofunction
0.000 0.862 0.138
E89.1 Postprocedural hypoinsulinaemia
0.000 0.862 0.138
E66.0 Obesity due to excess calories
0.000 0.863 0.137
E20.9 Hypoparathyroidism, unspecified
0.000 0.864 0.136
E55.9 Vitamin D deficiency, unspecified
0.000 0.866 0.134
E24.0 Pituitary-dependent Cushing's disease
0.000 0.866 0.134
E34.8 Other specified endocrine disorders
0.000 0.866 0.134
E89.2 Postprocedural hypoparathyroidism
0.000 0.866 0.133
E89.0 Postprocedural hypothyroidism
0.000 0.869 0.131
E80 Disorders of porphyrin and bilirubin metabolism
0.002 0.870 0.128
E23.0 Hypopituitarism
0.000 0.871 0.129
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.872 0.128
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.002 0.872 0.127
E79.8 Other disorders of purine and pyrimidine metabolism
0.002 0.872 0.127
E79.1 Lesch-Nyhan syndrome
0.002 0.872 0.127
E34.5 Androgen resistance syndrome
0.000 0.872 0.128
E34.4 Constitutional tall stature
0.000 0.872 0.128
E34.3 Short stature, not elsewhere classified
0.000 0.872 0.128
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.872 0.128
E34.1 Other hypersecretion of intestinal hormones
0.000 0.872 0.128
E26.0 Primary hyperaldosteronism
0.000 0.873 0.127
E89.4 Postprocedural ovarian failure
0.000 0.874 0.126
E28.9 Ovarian dysfunction, unspecified
0.000 0.875 0.125
E28.8 Other ovarian dysfunction
0.000 0.875 0.125
E28.1 Androgen excess
0.000 0.875 0.125
E28.0 Oestrogen excess
0.000 0.875 0.125
E28.3 Primary ovarian failure
0.000 0.875 0.125
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.877 0.123
E24.9 Cushing's syndrome, unspecified
0.000 0.879 0.120
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.880 0.120
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.002 0.881 0.118
E70.8 Other disorders of aromatic amino-acid metabolism
0.002 0.881 0.118
E70.3 Albinism
0.002 0.881 0.118
E70.2 Disorders of tyrosine metabolism
0.002 0.881 0.118
E70.1 Other hyperphenylalaninaemias
0.002 0.881 0.118
E70.0 Classical phenylketonuria
0.002 0.881 0.118
E71.3 Disorders of fatty-acid metabolism
0.002 0.881 0.118
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.002 0.881 0.118
E71.1 Other disorders of branched-chain amino-acid metabolism
0.002 0.881 0.118
E71.0 Maple-syrup-urine disease
0.002 0.881 0.118
E72.9 Disorder of amino-acid metabolism, unspecified
0.002 0.881 0.118
E72.8 Other specified disorders of amino-acid metabolism
0.002 0.881 0.118
E72.5 Disorders of glycine metabolism
0.002 0.881 0.118
E72.4 Disorders of ornithine metabolism
0.002 0.881 0.118
E72.3 Disorders of lysine and hydroxylysine metabolism
0.002 0.881 0.118
E72.2 Disorders of urea cycle metabolism
0.002 0.881 0.118
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.002 0.881 0.118
E72.0 Disorders of amino-acid transport
0.002 0.881 0.118
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.002 0.881 0.118
E76.8 Other disorders of glucosaminoglycan metabolism
0.002 0.881 0.118
E76.3 Mucopolysaccharidosis, unspecified
0.002 0.881 0.118
E76.2 Other mucopolysaccharidoses
0.002 0.881 0.118
E76.1 Mucopolysaccharidosis, type II
0.002 0.881 0.118
E76.0 Mucopolysaccharidosis, type I
0.002 0.881 0.118
E77.9 Disorder of glycoprotein metabolism, unspecified
0.002 0.881 0.118
E77.8 Other disorders of glycoprotein metabolism
0.002 0.881 0.118
E77.1 Defects in glycoprotein degradation
0.002 0.881 0.118
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.002 0.881 0.118
E66.1 Drug-induced obesity
0.000 0.883 0.116
E21.4 Other specified disorders of parathyroid gland
0.000 0.884 0.116
E21.2 Other hyperparathyroidism
0.000 0.884 0.116
E34.0 Carcinoid syndrome
0.000 0.886 0.114
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.887 0.112
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.887 0.113
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.889 0.111
E53.1 Pyridoxine deficiency
0.000 0.891 0.109
E53.0 Riboflavin deficiency
0.000 0.891 0.109
E74.9 Disorder of carbohydrate metabolism, unspecified
0.002 0.891 0.108
E74.8 Other specified disorders of carbohydrate metabolism
0.002 0.891 0.108
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.002 0.891 0.108
E74.2 Disorders of galactose metabolism
0.002 0.891 0.108
E74.1 Disorders of fructose metabolism
0.002 0.891 0.108
E84.8 Cystic fibrosis with other manifestations
0.002 0.895 0.103
E84.1 Cystic fibrosis with intestinal manifestations
0.002 0.895 0.103
E73.8 Other lactose intolerance
0.002 0.895 0.103
E73.1 Secondary lactase deficiency
0.002 0.895 0.103
E73.0 Congenital lactase deficiency
0.002 0.895 0.103
E75.6 Lipid storage disorder, unspecified
0.002 0.896 0.102
E75.4 Neuronal ceroid lipofuscinosis
0.002 0.896 0.102
E75.3 Sphingolipidosis, unspecified
0.002 0.896 0.102
E75.1 Other gangliosidosis
0.002 0.896 0.102
E75.0 GM2 gangliosidosis
0.002 0.896 0.102
E04.8 Other specified non-toxic goitre
0.000 0.898 0.102
E75.5 Other lipid storage disorders
0.002 0.898 0.100
L40 Psoriasis
0.102 0.898 0.000
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.902 0.097
E84.9 Cystic fibrosis, unspecified
0.002 0.903 0.095
E84.0 Cystic fibrosis with pulmonary manifestations
0.002 0.905 0.093
E80.6 Other disorders of bilirubin metabolism
0.001 0.906 0.093
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.906 0.092
E80.5 Crigler-Najjar syndrome
0.001 0.906 0.092
E80.3 Defects of catalase and peroxydase
0.001 0.906 0.092
E80.2 Other porphyria
0.001 0.906 0.092
E80.1 Porphyria cutanea tarda
0.001 0.906 0.092
E80.0 Hereditary erythropoietic porphyria
0.001 0.906 0.092
E21.3 Hyperparathyroidism, unspecified
0.000 0.907 0.093
L40.0 Psoriasis vulgaris
0.091 0.909 0.000
E74.0 Glycogen storage disease
0.002 0.910 0.088
E27 Other disorders of adrenal gland
0.000 0.913 0.087

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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