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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3115537
log Bayes Factor = 64.4347
Chromosome 6   position 31,497,835  (GRCh37) Explore rs3115537 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.001 0.999
I25.1 Atherosclerotic heart disease
0.000 0.001 0.999
E78.0 Pure hypercholesterolaemia
0.000 0.001 0.999
I20 Angina pectoris
0.000 0.004 0.996
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.007 0.993
E14.3 With ophthalmic complications
0.000 0.010 0.990
I25.5 Ischaemic cardiomyopathy
0.000 0.012 0.988
E14.9 Without complications
0.000 0.012 0.988
E10.1 With ketoacidosis
0.000 0.012 0.988
I20.9 Angina pectoris, unspecified
0.000 0.014 0.986
E10.4 With neurological complications
0.000 0.017 0.983
I22 Subsequent myocardial infarction
0.000 0.019 0.981
I20.0 Unstable angina
0.000 0.024 0.976
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.026 0.974
G35-G37 Demyelinating diseases of the central nervous system
0.962 0.038 0.000
I25.2 Old myocardial infarction
0.000 0.039 0.961
E83.1 Disorders of iron metabolism
0.959 0.041 0.000
G37 Other demyelinating diseases of central nervous system
0.955 0.045 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.048 0.952
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.051 0.949
I21 Acute myocardial infarction
0.000 0.053 0.947
E70-E90 Metabolic disorders
0.000 0.060 0.940
G37.9 Demyelinating disease of central nervous system, unspecified
0.936 0.064 0.000
E13 Other specified diabetes mellitus
0.000 0.073 0.927
I10 Essential (primary) hypertension
0.000 0.082 0.918
I21.9 Acute myocardial infarction, unspecified
0.000 0.095 0.905
I24 Other acute ischaemic heart diseases
0.000 0.105 0.895
E78.8 Other disorders of lipoprotein metabolism
0.000 0.109 0.891
E00-E07 Disorders of thyroid gland
0.000 0.110 0.890
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.116 0.884
E10.2 With renal complications
0.000 0.117 0.883
E11.2 With renal complications
0.000 0.122 0.878
L40-L45 Papulosquamous disorders
0.000 0.126 0.874
E13.9 Without complications
0.000 0.126 0.874
E11.0 With coma
0.000 0.134 0.866
E03 Other hypothyroidism
0.000 0.135 0.865
E03.9 Hypothyroidism, unspecified
0.000 0.142 0.858
L40.8 Other psoriasis
0.000 0.145 0.855
I25.3 Aneurysm of heart
0.000 0.152 0.848
L43 Lichen planus
0.000 0.152 0.848
R07.4 Chest pain, unspecified
0.000 0.155 0.845
I10-I15 Hypertensive diseases
0.000 0.159 0.841
E11.1 With ketoacidosis
0.000 0.163 0.837
G37.8 Other specified demyelinating diseases of central nervous system
0.837 0.163 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.165 0.835
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.166 0.834
E14.4 With neurological complications
0.000 0.175 0.825
I21.4 Acute subendocardial myocardial infarction
0.000 0.176 0.824
E10.8 With unspecified complications
0.000 0.179 0.821
L43.9 Lichen planus, unspecified
0.000 0.182 0.818
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.184 0.816
E05.9 Thyrotoxicosis, unspecified
0.000 0.198 0.802
E10.5 With peripheral circulatory complications
0.000 0.200 0.800
E10.0 With coma
0.000 0.205 0.794
E78.2 Mixed hyperlipidaemia
0.000 0.206 0.794
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.206 0.794
L40.0 Psoriasis vulgaris
0.000 0.218 0.782
E85 Amyloidosis
0.000 0.223 0.777
I23 Certain current complications following acute myocardial infarction
0.000 0.224 0.776
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.775 0.225 0.000
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.227 0.773
E11.6 With other specified complications
0.000 0.228 0.772
I24.8 Other forms of acute ischaemic heart disease
0.000 0.238 0.762
E16 Other disorders of pancreatic internal secretion
0.000 0.247 0.753
I15 Secondary hypertension
0.000 0.259 0.741
E78.6 Lipoprotein deficiency
0.000 0.260 0.740
E10.6 With other specified complications
0.000 0.265 0.735
E14.5 With peripheral circulatory complications
0.000 0.265 0.734
E74 Other disorders of carbohydrate metabolism
0.000 0.266 0.734
E14.6 With other specified complications
0.000 0.278 0.722
I12 Hypertensive renal disease
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.2 Withrenal complications
0.000 0.283 0.717
E14.1 With ketoacidosis
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
E78.1 Pure hyperglyceridaemia
0.000 0.288 0.712
E78.3 Hyperchylomicronaemia
0.000 0.302 0.698
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.302 0.698
L40.3 Pustulosis palmaris et plantaris
0.000 0.305 0.695
E11.5 With peripheral circulatory complications
0.000 0.305 0.695
L43.8 Other lichen planus
0.000 0.306 0.694
G36 Other acute disseminated demyelination
0.693 0.307 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.312 0.688
G37.5 Concentric sclerosis [Balo]
0.684 0.315 0.000
G37.4 Subacute necrotising myelitis
0.684 0.315 0.000
G37.2 Central pontine myelinolysis
0.684 0.315 0.000
G37.1 Central demyelination of corpus callosum
0.684 0.315 0.000
G37.0 Diffuse sclerosis
0.684 0.315 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.321 0.679
E16.2 Hypoglycaemia, unspecified
0.000 0.324 0.676
E77 Disorders of glycoprotein metabolism
0.000 0.326 0.674
E76 Disorders of glycosaminoglycan metabolism
0.000 0.326 0.674
E72 Other disorders of amino-acid metabolism
0.000 0.326 0.674
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.326 0.674
E70 Disorders of aromatic amino-acid metabolism
0.000 0.326 0.674
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.326 0.674
I15.1 Hypertension secondary to other renal disorders
0.000 0.327 0.673
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.331 0.669
E79 Disorders of purine and pyrimidine metabolism
0.000 0.332 0.668
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.335 0.665
E13.8 With unspecified complications
0.000 0.336 0.664
E13.7 With multiple complications
0.000 0.336 0.664
E13.6 With other specified complications
0.000 0.336 0.664
E13.5 With peripheral circulatory complications
0.000 0.336 0.664
E13.4 With neurological complications
0.000 0.336 0.664
E13.3 With ophthalmic complications
0.000 0.336 0.664
E13.2 With renal complications
0.000 0.336 0.664
E13.1 With ketoacidosis
0.000 0.336 0.664
E13.0 With coma
0.000 0.336 0.664
E78.4 Other hyperlipidaemia
0.000 0.336 0.664
I22.8 Subsequent myocardial infarction of other sites
0.000 0.339 0.661
E85.9 Amyloidosis, unspecified
0.000 0.341 0.659
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.347 0.653
I12.9 Hypertensive renal disease without renal failure
0.000 0.361 0.639
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.362 0.638
E00 Congenital iodine-deficiency syndrome
0.000 0.362 0.638
L42 Pityriasis rosea
0.000 0.364 0.635
I11 Hypertensive heart disease
0.000 0.366 0.634
L44 Other papulosquamous disorders
0.000 0.373 0.627
L41 Parapsoriasis
0.000 0.373 0.627
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.373 0.627
E78.5 Hyperlipidaemia, unspecified
0.000 0.373 0.627
I20.1 Angina pectoris with documented spasm
0.000 0.377 0.623
E03.5 Myxoedema coma
0.000 0.379 0.620
E03.4 Atrophy of thyroid (acquired)
0.000 0.379 0.620
E03.3 Postinfectious hypothyroidism
0.000 0.379 0.620
E03.1 Congenital hypothyroidism without goitre
0.000 0.379 0.620
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.379 0.620
E84 Cystic fibrosis
0.000 0.382 0.617
I23.8 Other current complications following acute myocardial infarction
0.000 0.384 0.616
E11.4 With neurological complications
0.000 0.385 0.615
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.389 0.611
L43.3 Subacute (active) lichen planus
0.000 0.392 0.608
L43.2 Lichenoid drug reaction
0.000 0.392 0.608
L43.1 Bullous lichen planus
0.000 0.392 0.608
L43.0 Hypertrophic lichen planus
0.000 0.392 0.608
E40-E46 Malnutrition
0.000 0.396 0.604
I13 Hypertensive heart and renal disease
0.000 0.397 0.603
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.400 0.600
E15 Nondiabetic hypoglycaemic coma
0.000 0.401 0.599
E05.5 Thyroid crisis or storm
0.000 0.402 0.598
E05.4 Thyrotoxicosis factitia
0.000 0.402 0.598
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.402 0.598
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.402 0.598
E16.1 Other hypoglycaemia
0.000 0.407 0.593
E07 Other disorders of thyroid
0.000 0.412 0.588
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.413 0.586
I25.4 Coronary artery aneurysm
0.000 0.417 0.583
E85.4 Organ-limited amyloidosis
0.000 0.431 0.569
E85.8 Other amyloidosis
0.000 0.443 0.557
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.443 0.557
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.443 0.557
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.443 0.557
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.443 0.556
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.443 0.556
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.443 0.556
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.443 0.556
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.443 0.556
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.443 0.556
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.443 0.556
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.449 0.551
Chapter IX Diseases of the circulatory system
0.000 0.449 0.551
E73 Lactose intolerance
0.000 0.450 0.550
E11.3 With ophthalmic complications
0.000 0.452 0.548
E85.3 Secondary systemic amyloidosis
0.000 0.454 0.546
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.458 0.542
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.460 0.540
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.460 0.540
E16.4 Abnormal secretion of gastrin
0.000 0.460 0.540
E16.3 Increased secretion of glucagon
0.000 0.460 0.540
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.463 0.536
I15.8 Other secondary hypertension
0.000 0.469 0.531
I15.2 Hypertension secondary to endocrine disorders
0.000 0.469 0.531
I15.0 Renovascular hypertension
0.000 0.469 0.531
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.474 0.526
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.474 0.526
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.474 0.526
E74.2 Disorders of galactose metabolism
0.000 0.474 0.526
E74.1 Disorders of fructose metabolism
0.000 0.474 0.526
E74.0 Glycogen storage disease
0.000 0.474 0.526
E89.3 Postprocedural hypopituitarism
0.000 0.477 0.523
E06 Thyroiditis
0.000 0.478 0.522
I15.9 Seconday hypertension, unspecified
0.000 0.478 0.522
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.480 0.520
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.482 0.517
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
I24.1 Dressler's syndrome
0.000 0.489 0.511
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.492 0.508
E11.8 With unspecified complications
0.000 0.497 0.502
G36.0 Neuromyelitis optica [Devic]
0.500 0.500 0.000
G36.9 Acute disseminated demyelination, unspecified
0.497 0.503 0.000
G36.8 Other specified acute disseminated demyelination
0.497 0.503 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.497 0.503 0.000
E05.8 Other thyrotoxicosis
0.000 0.509 0.491
E88 Other metabolic disorders
0.000 0.512 0.487
I12.0 Hypertensive renal disease with renal failure
0.000 0.512 0.488
E83 Disorders of mineral metabolism
0.342 0.514 0.143
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.517 0.483
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.517 0.483
E70.3 Albinism
0.000 0.517 0.483
E70.2 Disorders of tyrosine metabolism
0.000 0.517 0.483
E70.1 Other hyperphenylalaninaemias
0.000 0.517 0.483
E70.0 Classical phenylketonuria
0.000 0.517 0.483
E71.3 Disorders of fatty-acid metabolism
0.000 0.517 0.483
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.517 0.483
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.517 0.483
E71.0 Maple-syrup-urine disease
0.000 0.517 0.483
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.517 0.483
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.517 0.483
E72.5 Disorders of glycine metabolism
0.000 0.517 0.483
E72.4 Disorders of ornithine metabolism
0.000 0.517 0.483
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.517 0.483
E72.2 Disorders of urea cycle metabolism
0.000 0.517 0.483
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.517 0.483
E72.0 Disorders of amino-acid transport
0.000 0.517 0.483
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.517 0.483
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.517 0.483
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.517 0.483
E76.2 Other mucopolysaccharidoses
0.000 0.517 0.483
E76.1 Mucopolysaccharidosis, type II
0.000 0.517 0.483
E76.0 Mucopolysaccharidosis, type I
0.000 0.517 0.483
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.517 0.483
E77.8 Other disorders of glycoprotein metabolism
0.000 0.517 0.483
E77.1 Defects in glycoprotein degradation
0.000 0.517 0.483
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.517 0.483
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.521 0.479
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.521 0.479
E79.1 Lesch-Nyhan syndrome
0.000 0.521 0.479
E75.6 Lipid storage disorder, unspecified
0.000 0.523 0.477
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.523 0.477
E75.3 Sphingolipidosis, unspecified
0.000 0.523 0.477
E75.2 Other sphingolipidosis
0.000 0.523 0.477
E75.1 Other gangliosidosis
0.000 0.523 0.477
E75.0 GM2 gangliosidosis
0.000 0.523 0.477
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.527 0.473
E75.5 Other lipid storage disorders
0.000 0.532 0.468
E65-E68 Obesity and other hyperalimentation
0.000 0.541 0.459
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.542 0.458
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.542 0.458
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.542 0.458
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.542 0.458
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.542 0.458
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.542 0.458
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.542 0.458
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.542 0.458
L41.9 Parapsoriasis, unspecified
0.000 0.550 0.450
L41.8 Other parapsoriasis
0.000 0.550 0.450
L41.5 Retiform parapsoriasis
0.000 0.550 0.450
L41.4 Large plaque parapsoriasis
0.000 0.550 0.450
L41.3 Small plaque parapsoriasis
0.000 0.550 0.450
L41.2 Lymphomatoid papulosis
0.000 0.550 0.450
L41.1 Pityriasis lichenoides chronica
0.000 0.550 0.450
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.550 0.450
L44.9 Papulosquamous disorder, unspecified
0.000 0.550 0.450
L44.8 Other specified papulosquamous disorders
0.000 0.550 0.450
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.550 0.450
L44.3 Lichen ruber moniliformis
0.000 0.550 0.450
L44.2 Lichen striatus
0.000 0.550 0.450
L44.1 Lichen nitidus
0.000 0.550 0.450
L44.0 Pityriasis rubra pilaris
0.000 0.550 0.450
E84.8 Cystic fibrosis with other manifestations
0.000 0.557 0.443
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.557 0.443
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.557 0.443
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.567 0.433
E45 Retarded development following protein-energy malnutrition
0.000 0.567 0.433
E43 Unspecified severe protein-energy malnutrition
0.000 0.567 0.433
E42 Marasmic kwashiorkor
0.000 0.567 0.433
E41 Nutritional marasmus
0.000 0.567 0.433
E40 Kwashiorkor
0.000 0.567 0.433
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.567 0.432
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.567 0.432
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.567 0.432
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.567 0.432
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.570 0.430
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.570 0.430
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.570 0.430
E89.5 Postprocedural testicular hypofunction
0.000 0.570 0.430
E89.1 Postprocedural hypoinsulinaemia
0.000 0.570 0.430
K90 Intestinal malabsorption
0.000 0.577 0.423
E07.1 Dyshormogenetic goitre
0.000 0.578 0.422
E07.0 Hypersecretion of calcitonin
0.000 0.578 0.422
E07.8 Other specified disorders of thyroid
0.000 0.579 0.421
E50-E64 Other nutritional deficiencies
0.000 0.585 0.414
E89.4 Postprocedural ovarian failure
0.000 0.595 0.404
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.600 0.400
I00-I02 Acute rheumatic fever
0.000 0.605 0.395
E73.8 Other lactose intolerance
0.000 0.605 0.394
E73.1 Secondary lactase deficiency
0.000 0.605 0.394
E73.0 Congenital lactase deficiency
0.000 0.605 0.394
E88.2 Lipomatosis, not elsewhere classified
0.000 0.611 0.388
E84.9 Cystic fibrosis, unspecified
0.000 0.613 0.386
E80.6 Other disorders of bilirubin metabolism
0.000 0.618 0.382
E89.2 Postprocedural hypoparathyroidism
0.000 0.618 0.381
E06.5 Other chronic thyroiditis
0.000 0.625 0.375
E06.4 Drug-induced thyroiditis
0.000 0.625 0.375
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.625 0.375
E06.1 Subacute thyroiditis
0.000 0.625 0.375
E06.0 Acute thyroiditis
0.000 0.625 0.375
E07.9 Disorder of thyroid, unspecified
0.000 0.627 0.373
E03.8 Other specified hypothyroidism
0.001 0.631 0.369
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.635 0.364
E80.5 Crigler-Najjar syndrome
0.000 0.635 0.364
E80.3 Defects of catalase and peroxydase
0.000 0.635 0.364
E80.2 Other porphyria
0.000 0.635 0.364
E80.1 Porphyria cutanea tarda
0.000 0.635 0.364
E80.0 Hereditary erythropoietic porphyria
0.000 0.635 0.364
E06.9 Thyroiditis, unspecified
0.000 0.643 0.357
E46 Unspecified protein-energy malnutrition
0.000 0.644 0.356
E88.8 Other specified metabolic disorders
0.000 0.648 0.351
E88.9 Metabolic disorder, unspecified
0.000 0.650 0.350
E88.3 Tumour lysis syndrome
0.000 0.650 0.350
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.651 0.349
E83.9 Disorder of mineral metabolism, unspecified
0.246 0.651 0.103
E83.8 Other disorders of mineral metabolism
0.246 0.651 0.103
E83.2 Disorders of zinc metabolism
0.246 0.651 0.103
E83.0 Disorders of copper metabolism
0.246 0.651 0.103
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.652 0.347
E83.3 Disorders of phosphorus metabolism
0.285 0.665 0.050
E67 Other hyperalimentation
0.000 0.671 0.329
E68 Sequelae of hyperalimentation
0.000 0.671 0.329
E65 Localised adiposity
0.000 0.679 0.321
E44.1 Mild protein-energy malnutrition
0.000 0.689 0.310
E44.0 Moderate protein-energy malnutrition
0.000 0.689 0.310
E61 Deficiency of other nutrient elements
0.000 0.691 0.309
K90.9 Intestinal malabsorption, unspecified
0.000 0.693 0.307
K90.8 Other intestinal malabsorption
0.000 0.696 0.304
K90.3 Pancreatic steatorrhoea
0.000 0.697 0.303
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.697 0.303
K90.1 Tropical sprue
0.000 0.697 0.303
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.703 0.297
E63 Other nutritional deficiencies
0.000 0.703 0.297
E56 Other vitamin deficiencies
0.000 0.703 0.297
E51 Thiamine deficiency
0.000 0.703 0.297
E50 Vitamin A deficiency
0.000 0.703 0.297
E60 Dietary zinc deficiency
0.000 0.703 0.297
E59 Dietary selenium deficiency
0.000 0.703 0.297
E58 Dietary calcium deficiency
0.000 0.703 0.297
E54 Ascorbic acid deficiency
0.000 0.703 0.297
E52 Niacin deficiency [pellagra]
0.000 0.703 0.297
E06.3 Autoimmune thyroiditis
0.000 0.713 0.287
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.715 0.284
I02 Rheumatic chorea
0.000 0.717 0.283
I01 Rheumatic fever with heart involvement
0.000 0.717 0.283
I00 Rheumatic fever without mention of heart involvement
0.000 0.717 0.283
E88.1 Lipodystrophy, not elsewhere classified
0.001 0.717 0.282
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.727 0.273
E73.9 Lactose intolerance, unspecified
0.001 0.729 0.270
E20-E35 Disorders of other endocrine glands
0.000 0.731 0.269
E61.1 Iron deficiency
0.000 0.759 0.241
E89.0 Postprocedural hypothyroidism
0.000 0.763 0.237
E55 Vitamin D deficiency
0.000 0.764 0.236
E67.8 Other specified hyperalimentation
0.000 0.764 0.236
E67.3 Hypervitaminosis D
0.000 0.764 0.236
E67.2 Megavitamin-B6 syndrome
0.000 0.764 0.236
E67.1 Hypercarotenaemia
0.000 0.764 0.236
E67.0 Hypervitaminosis A
0.000 0.764 0.236
E61.9 Deficiency of nutrient element, unspecified
0.000 0.778 0.222
E61.8 Deficiency of other specified nutrient elements
0.000 0.778 0.222
E61.7 Deficiency of multiple nutrient elements
0.000 0.778 0.222
E61.6 Vanadium deficiency
0.000 0.778 0.222
E61.5 Molybdenum deficiency
0.000 0.778 0.222
E61.4 Chromium deficiency
0.000 0.778 0.222
E61.3 Manganese deficiency
0.000 0.778 0.222
E61.0 Copper deficiency
0.000 0.778 0.222
E23 Hypofunction and other disorders of pituitary gland
0.000 0.778 0.222
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.001 0.784 0.215
E22 Hyperfunction of pituitary gland
0.000 0.785 0.214
E50.9 Vitamin A deficiency, unspecified
0.000 0.787 0.213
E50.8 Other manifestations of vitamin A deficiency
0.000 0.787 0.213
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.787 0.213
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.787 0.213
E50.5 Vitamin A deficiency with night blindness
0.000 0.787 0.213
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.787 0.213
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.787 0.213
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.787 0.213
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.787 0.213
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.787 0.213
E51.9 Thiamine deficiency, unspecified
0.000 0.787 0.213
E51.8 Other manifestations of thiamine deficiency
0.000 0.787 0.213
E51.2 Wernicke's encephalopathy
0.000 0.787 0.213
E51.1 Beriberi
0.000 0.787 0.213
E56.9 Vitamin deficiency, unspecified
0.000 0.787 0.213
E56.8 Deficiency of other vitamins
0.000 0.787 0.213
E56.1 Deficiency of vitamin K
0.000 0.787 0.213
E56.0 Deficiency of vitamin E
0.000 0.787 0.213
E63.9 Nutritional deficiency, unspecified
0.000 0.787 0.213
E63.8 Other specified nutritional deficiencies
0.000 0.787 0.213
E63.1 Imbalance of constituents of food intake
0.000 0.787 0.213
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.787 0.213
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.787 0.213
E64.8 Sequelae of other nutritional deficiencies
0.000 0.787 0.213
E64.3 Sequelae of rickets
0.000 0.787 0.213
E64.2 Sequelae of vitamin C deficiency
0.000 0.787 0.213
E64.1 Sequelae of vitamin A deficiency
0.000 0.787 0.213
E64.0 Sequelae of protein-energy malnutrition
0.000 0.787 0.213
E61.2 Magnesium deficiency
0.000 0.787 0.213
E83.4 Disorders of magnesium metabolism
0.108 0.796 0.096
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.797 0.203
I01.8 Other acute rheumatic heart disease
0.000 0.797 0.203
I01.2 Acute rheumatic myocarditis
0.000 0.797 0.203
I01.1 Acute rheumatic endocarditis
0.000 0.797 0.203
I01.0 Acute rheumatic pericarditis
0.000 0.797 0.203
I02.9 Rheumatic chorea without heart involvement
0.000 0.797 0.203
I02.0 Rheumatic chorea with heart involvement
0.000 0.797 0.203
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.807 0.193
E32 Diseases of thymus
0.000 0.807 0.193
E31 Polyglandular dysfunction
0.000 0.807 0.193
E30 Disorders of puberty, not elsewhere classified
0.000 0.807 0.193
E25 Adrenogenital disorders
0.000 0.807 0.193
E26 Hyperaldosteronism
0.000 0.811 0.189
E23.6 Other disorders of pituitary gland
0.000 0.813 0.187
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.817 0.183
E29 Testicular dysfunction
0.000 0.818 0.181
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.001 0.819 0.181
E23.2 Diabetes insipidus
0.000 0.819 0.181
E24 Cushing's syndrome
0.000 0.820 0.180
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.825 0.175
E20 Hypoparathyroidism
0.000 0.827 0.173
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.828 0.172
E55.0 Rickets, active
0.000 0.830 0.169
E23.7 Disorder of pituitary gland, unspecified
0.000 0.831 0.169
E28 Ovarian dysfunction
0.000 0.836 0.164
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.841 0.159
E23.1 Drug-induced hypopituitarism
0.000 0.841 0.159
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.842 0.158
E80.4 Gilbert's syndrome
0.000 0.844 0.156
E22.1 Hyperprolactinaemia
0.000 0.845 0.155
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.846 0.154
E22.8 Other hyperfunction of pituitary gland
0.000 0.846 0.154
I28 Other diseases of pulmonary vessels
0.001 0.847 0.152
E83.5 Disorders of calcium metabolism
0.120 0.852 0.028
E34 Other endocrine disorders
0.000 0.860 0.140
E22.0 Acromegaly and pituitary gigantism
0.000 0.860 0.140
E25.9 Adrenogenital disorder, unspecified
0.000 0.862 0.138
E25.8 Other adrenogenital disorders
0.000 0.862 0.138
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.862 0.138
E30.9 Disorder of puberty, unspecified
0.000 0.862 0.138
E30.8 Other disorders of puberty
0.000 0.862 0.138
E30.1 Precocious puberty
0.000 0.862 0.138
E30.0 Delayed puberty
0.000 0.862 0.138
E31.9 Polyglandular dysfunction, unspecified
0.000 0.862 0.138
E31.8 Other polyglandular dysfunction
0.000 0.862 0.138
E31.1 Polyglandular hyperfunction
0.000 0.862 0.138
E31.0 Autoimmune polyglandular failure
0.000 0.862 0.138
E32.9 Disease of thymus, unspecified
0.000 0.862 0.138
E32.8 Other diseases of thymus
0.000 0.862 0.138
E32.1 Abscess of thymus
0.000 0.862 0.138
E32.0 Persistent hyperplasia of thymus
0.000 0.862 0.138
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.862 0.138
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.862 0.138
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.862 0.138
E26.9 Hyperaldosteronism, unspecified
0.000 0.864 0.136
E26.8 Other hyperaldosteronism
0.000 0.864 0.136
E26.1 Secondary hyperaldosteronism
0.000 0.864 0.136
E53 Deficiency of other B group vitamins
0.001 0.866 0.133
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.867 0.133
E26.0 Primary hyperaldosteronism
0.000 0.867 0.132
E21.3 Hyperparathyroidism, unspecified
0.000 0.868 0.132
E29.9 Testicular dysfunction, unspecified
0.000 0.870 0.130
E29.8 Other testicular dysfunction
0.000 0.870 0.130
E29.0 Testicular hyperfunction
0.000 0.870 0.130
E24.8 Other Cushing's syndrome
0.000 0.870 0.129
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.870 0.129
E24.3 Ectopic ACTH syndrome
0.000 0.870 0.129
E24.2 Drug-induced Cushing's syndrome
0.000 0.870 0.129
E24.1 Nelson's syndrome
0.000 0.870 0.129
E24.0 Pituitary-dependent Cushing's disease
0.000 0.870 0.129
I05-I09 Chronic rheumatic heart diseases
0.000 0.872 0.128
E66 Obesity
0.000 0.873 0.127
I27 Other pulmonary heart diseases
0.001 0.874 0.125

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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