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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3129795
log Bayes Factor = 55.9612
Chromosome 6   position 28,984,755  (GRCh37) Explore rs3129795 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10.9 Without complications
0.000 0.001 0.999
E10-E14 Diabetes mellitus
0.000 0.005 0.995
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.018 0.982
E10.3 With ophthalmic complications
0.000 0.021 0.979
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.044 0.956
E10.2 With renal complications
0.000 0.045 0.955
E00-E07 Disorders of thyroid gland
0.000 0.058 0.942
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.061 0.939
E05.9 Thyrotoxicosis, unspecified
0.000 0.062 0.938
E16 Other disorders of pancreatic internal secretion
0.000 0.062 0.938
E16.2 Hypoglycaemia, unspecified
0.000 0.080 0.920
E20-E35 Disorders of other endocrine glands
0.000 0.081 0.919
E10.4 With neurological complications
0.000 0.082 0.918
E14 Unspecified diabetes mellitus
0.000 0.123 0.877
E10.5 With peripheral circulatory complications
0.000 0.138 0.862
E24 Cushing's syndrome
0.000 0.153 0.847
E13 Other specified diabetes mellitus
0.000 0.162 0.838
E23 Hypofunction and other disorders of pituitary gland
0.000 0.174 0.826
E10.1 With ketoacidosis
0.000 0.181 0.819
E10.6 With other specified complications
0.000 0.188 0.812
E05.8 Other thyrotoxicosis
0.000 0.214 0.786
E16.1 Other hypoglycaemia
0.000 0.217 0.783
E24.9 Cushing's syndrome, unspecified
0.000 0.220 0.780
E10.0 With coma
0.000 0.220 0.780
E20 Hypoparathyroidism
0.000 0.222 0.778
E13.9 Without complications
0.000 0.264 0.736
E50-E64 Other nutritional deficiencies
0.000 0.264 0.736
E14.1 With ketoacidosis
0.000 0.271 0.729
E28 Ovarian dysfunction
0.000 0.272 0.728
E14.3 With ophthalmic complications
0.000 0.279 0.721
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.287 0.713
E23.2 Diabetes insipidus
0.000 0.297 0.703
E23.7 Disorder of pituitary gland, unspecified
0.000 0.301 0.699
E14.5 With peripheral circulatory complications
0.000 0.305 0.695
E29 Testicular dysfunction
0.000 0.306 0.694
E07 Other disorders of thyroid
0.000 0.310 0.690
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.310 0.690
E15 Nondiabetic hypoglycaemic coma
0.000 0.314 0.685
E25 Adrenogenital disorders
0.000 0.317 0.683
E34 Other endocrine disorders
0.000 0.320 0.680
E20.9 Hypoparathyroidism, unspecified
0.000 0.324 0.676
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.325 0.675
E00 Congenital iodine-deficiency syndrome
0.000 0.325 0.675
E05.5 Thyroid crisis or storm
0.000 0.327 0.673
E05.4 Thyrotoxicosis factitia
0.000 0.327 0.673
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.327 0.673
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.327 0.673
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.327 0.672
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.327 0.672
E16.4 Abnormal secretion of gastrin
0.000 0.327 0.672
E16.3 Increased secretion of glucagon
0.000 0.327 0.672
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.333 0.667
E40-E46 Malnutrition
0.000 0.333 0.667
E24.2 Drug-induced Cushing's syndrome
0.000 0.340 0.660
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.341 0.659
E32 Diseases of thymus
0.000 0.341 0.659
E30 Disorders of puberty, not elsewhere classified
0.000 0.341 0.659
E23.0 Hypopituitarism
0.000 0.346 0.654
E14.8 With unspecified complications
0.000 0.352 0.648
E06 Thyroiditis
0.000 0.360 0.640
E14.4 With neurological complications
0.000 0.361 0.638
E55 Vitamin D deficiency
0.000 0.363 0.637
E11 Non-insulin-dependent diabetes mellitus
0.000 0.365 0.635
E14.2 Withrenal complications
0.000 0.369 0.631
E14.7 With multiple complications
0.000 0.371 0.629
E14.6 With other specified complications
0.000 0.371 0.629
E14.0 With coma
0.000 0.371 0.629
E24.8 Other Cushing's syndrome
0.000 0.393 0.607
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.393 0.607
E24.3 Ectopic ACTH syndrome
0.000 0.393 0.607
E24.1 Nelson's syndrome
0.000 0.393 0.607
E24.0 Pituitary-dependent Cushing's disease
0.000 0.393 0.607
E31 Polyglandular dysfunction
0.000 0.394 0.605
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.395 0.604
E13.8 With unspecified complications
0.000 0.399 0.601
E13.7 With multiple complications
0.000 0.399 0.601
E13.6 With other specified complications
0.000 0.399 0.601
E13.5 With peripheral circulatory complications
0.000 0.399 0.601
E13.4 With neurological complications
0.000 0.399 0.601
E13.2 With renal complications
0.000 0.399 0.601
E13.1 With ketoacidosis
0.000 0.399 0.601
E13.0 With coma
0.000 0.399 0.601
E28.2 Polycystic ovarian syndrome
0.000 0.402 0.598
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.407 0.592
E23.1 Drug-induced hypopituitarism
0.000 0.407 0.592
E22 Hyperfunction of pituitary gland
0.000 0.411 0.589
E11.6 With other specified complications
0.000 0.421 0.579
E70-E90 Metabolic disorders
0.001 0.424 0.575
E13.3 With ophthalmic complications
0.000 0.425 0.575
E78.0 Pure hypercholesterolaemia
0.000 0.425 0.575
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.426 0.574
E55.9 Vitamin D deficiency, unspecified
0.000 0.433 0.567
E10.8 With unspecified complications
0.000 0.439 0.560
E20.8 Other hypoparathyroidism
0.000 0.442 0.558
E20.1 Pseudohypoparathyroidism
0.000 0.442 0.558
E20.0 Idiopathic hypoparathyroidism
0.000 0.442 0.558
E11.2 With renal complications
0.000 0.446 0.554
E27 Other disorders of adrenal gland
0.000 0.447 0.553
E07.8 Other specified disorders of thyroid
0.000 0.463 0.537
E34.8 Other specified endocrine disorders
0.000 0.465 0.535
E14.9 Without complications
0.000 0.466 0.534
E29.1 Testicular hypofunction
0.000 0.468 0.532
E06.9 Thyroiditis, unspecified
0.000 0.469 0.531
E11.0 With coma
0.000 0.470 0.530
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.472 0.527
E63 Other nutritional deficiencies
0.000 0.472 0.527
E56 Other vitamin deficiencies
0.000 0.472 0.527
E50 Vitamin A deficiency
0.000 0.472 0.527
E60 Dietary zinc deficiency
0.000 0.472 0.527
E59 Dietary selenium deficiency
0.000 0.472 0.527
E54 Ascorbic acid deficiency
0.000 0.472 0.527
E52 Niacin deficiency [pellagra]
0.000 0.472 0.527
E51 Thiamine deficiency
0.000 0.473 0.526
E11.1 With ketoacidosis
0.000 0.477 0.522
E28.9 Ovarian dysfunction, unspecified
0.000 0.478 0.522
E28.8 Other ovarian dysfunction
0.000 0.478 0.522
E28.1 Androgen excess
0.000 0.478 0.522
E28.0 Oestrogen excess
0.000 0.478 0.522
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.487 0.513
E58 Dietary calcium deficiency
0.000 0.487 0.513
E28.3 Primary ovarian failure
0.000 0.488 0.512
E12.9 Without complications
0.000 0.489 0.511
E12.8 With unspecified complications
0.000 0.489 0.511
E12.7 With multiple complications
0.000 0.489 0.511
E12.6 With other specified complications
0.000 0.489 0.511
E12.5 With peripheral circulatory complications
0.000 0.489 0.511
E12.4 With neurological complications
0.000 0.489 0.511
E12.3 With ophthalmic complications
0.000 0.489 0.511
E12.2 With renal complications
0.000 0.489 0.511
E12.1 With ketoacidosis
0.000 0.489 0.511
E12.0 With coma
0.000 0.489 0.511
E23.6 Other disorders of pituitary gland
0.000 0.490 0.510
E78.5 Hyperlipidaemia, unspecified
0.000 0.495 0.505
E29.9 Testicular dysfunction, unspecified
0.000 0.502 0.498
E29.8 Other testicular dysfunction
0.000 0.502 0.498
E29.0 Testicular hyperfunction
0.000 0.502 0.498
E07.1 Dyshormogenetic goitre
0.000 0.505 0.494
E07.0 Hypersecretion of calcitonin
0.000 0.505 0.494
E26 Hyperaldosteronism
0.001 0.506 0.493
E78.1 Pure hyperglyceridaemia
0.000 0.507 0.493
E25.9 Adrenogenital disorder, unspecified
0.000 0.510 0.489
E25.8 Other adrenogenital disorders
0.000 0.510 0.489
E34.5 Androgen resistance syndrome
0.000 0.512 0.488
E34.4 Constitutional tall stature
0.000 0.512 0.488
E34.3 Short stature, not elsewhere classified
0.000 0.512 0.488
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.512 0.488
E34.1 Other hypersecretion of intestinal hormones
0.000 0.512 0.488
E85 Amyloidosis
0.000 0.516 0.484
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.516 0.484
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.516 0.484
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.516 0.484
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.516 0.484
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.516 0.484
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.516 0.484
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.516 0.484
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.516 0.484
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.519 0.481
E34.9 Endocrine disorder, unspecified
0.000 0.519 0.481
E22.0 Acromegaly and pituitary gigantism
0.000 0.521 0.479
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.522 0.478
E45 Retarded development following protein-energy malnutrition
0.000 0.522 0.478
E43 Unspecified severe protein-energy malnutrition
0.000 0.522 0.478
E42 Marasmic kwashiorkor
0.000 0.522 0.478
E41 Nutritional marasmus
0.000 0.522 0.478
E40 Kwashiorkor
0.000 0.522 0.478
E74 Other disorders of carbohydrate metabolism
0.001 0.525 0.474
E30.9 Disorder of puberty, unspecified
0.000 0.527 0.473
E30.8 Other disorders of puberty
0.000 0.527 0.473
E30.1 Precocious puberty
0.000 0.527 0.473
E30.0 Delayed puberty
0.000 0.527 0.473
E32.9 Disease of thymus, unspecified
0.000 0.527 0.473
E32.8 Other diseases of thymus
0.000 0.527 0.473
E32.1 Abscess of thymus
0.000 0.527 0.473
E32.0 Persistent hyperplasia of thymus
0.000 0.527 0.473
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.527 0.473
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.527 0.473
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.527 0.473
E61 Deficiency of other nutrient elements
0.000 0.531 0.469
E78.2 Mixed hyperlipidaemia
0.000 0.534 0.466
E53 Deficiency of other B group vitamins
0.000 0.536 0.464
E34.0 Carcinoid syndrome
0.000 0.540 0.460
E06.5 Other chronic thyroiditis
0.000 0.541 0.459
E06.4 Drug-induced thyroiditis
0.000 0.541 0.459
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.541 0.459
E06.1 Subacute thyroiditis
0.000 0.541 0.459
E06.0 Acute thyroiditis
0.000 0.541 0.459
E07.9 Disorder of thyroid, unspecified
0.000 0.541 0.459
E55.0 Rickets, active
0.000 0.543 0.457
E11.7 With multiple complications
0.000 0.545 0.455
E46 Unspecified protein-energy malnutrition
0.000 0.559 0.441
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.440 0.560 0.000
K90 Intestinal malabsorption
0.002 0.563 0.435
E31.9 Polyglandular dysfunction, unspecified
0.000 0.566 0.434
E31.8 Other polyglandular dysfunction
0.000 0.566 0.434
E31.1 Polyglandular hyperfunction
0.000 0.566 0.434
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.578 0.422
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.578 0.422
E22.8 Other hyperfunction of pituitary gland
0.000 0.578 0.422
E79 Disorders of purine and pyrimidine metabolism
0.001 0.587 0.412
E77 Disorders of glycoprotein metabolism
0.001 0.587 0.412
E76 Disorders of glycosaminoglycan metabolism
0.001 0.587 0.412
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.587 0.412
E72 Other disorders of amino-acid metabolism
0.001 0.587 0.412
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.587 0.412
E70 Disorders of aromatic amino-acid metabolism
0.001 0.587 0.412
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.587 0.412
E78.6 Lipoprotein deficiency
0.000 0.588 0.412
E78.3 Hyperchylomicronaemia
0.000 0.588 0.412
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.593 0.407
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.596 0.404
E73 Lactose intolerance
0.001 0.597 0.402
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.598 0.402
E53.9 Vitamin B deficiency, unspecified
0.000 0.598 0.402
E84 Cystic fibrosis
0.001 0.600 0.399
E27.5 Adrenomedullary hyperfunction
0.000 0.603 0.397
E27.0 Other adrenocortical overactivity
0.000 0.603 0.397
E85.4 Organ-limited amyloidosis
0.000 0.606 0.393
E83 Disorders of mineral metabolism
0.344 0.608 0.048
E27.9 Disorder of adrenal gland, unspecified
0.000 0.611 0.389
E65-E68 Obesity and other hyperalimentation
0.000 0.614 0.386
E31.0 Autoimmune polyglandular failure
0.000 0.619 0.380
E88 Other metabolic disorders
0.001 0.620 0.379
E50.9 Vitamin A deficiency, unspecified
0.000 0.622 0.378
E50.8 Other manifestations of vitamin A deficiency
0.000 0.622 0.378
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.622 0.378
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.622 0.378
E50.5 Vitamin A deficiency with night blindness
0.000 0.622 0.378
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.622 0.378
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.622 0.378
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.622 0.378
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.622 0.378
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.622 0.378
E56.9 Vitamin deficiency, unspecified
0.000 0.622 0.378
E56.8 Deficiency of other vitamins
0.000 0.622 0.378
E56.1 Deficiency of vitamin K
0.000 0.622 0.378
E56.0 Deficiency of vitamin E
0.000 0.622 0.378
E63.9 Nutritional deficiency, unspecified
0.000 0.622 0.378
E63.8 Other specified nutritional deficiencies
0.000 0.622 0.378
E63.1 Imbalance of constituents of food intake
0.000 0.622 0.378
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.622 0.378
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.622 0.378
E64.8 Sequelae of other nutritional deficiencies
0.000 0.622 0.378
E64.3 Sequelae of rickets
0.000 0.622 0.378
E64.2 Sequelae of vitamin C deficiency
0.000 0.622 0.378
E64.1 Sequelae of vitamin A deficiency
0.000 0.622 0.378
E64.0 Sequelae of protein-energy malnutrition
0.000 0.622 0.378
E51.9 Thiamine deficiency, unspecified
0.000 0.622 0.377
E51.8 Other manifestations of thiamine deficiency
0.000 0.622 0.377
E51.1 Beriberi
0.000 0.622 0.377
E85.3 Secondary systemic amyloidosis
0.000 0.623 0.377
E51.2 Wernicke's encephalopathy
0.000 0.623 0.377
E27.8 Other specified disorders of adrenal gland
0.000 0.625 0.375
E78.4 Other hyperlipidaemia
0.000 0.626 0.373
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.001 0.627 0.373
E22.1 Hyperprolactinaemia
0.000 0.632 0.368
E27.1 Primary adrenocortical insufficiency
0.000 0.635 0.365
E03 Other hypothyroidism
0.000 0.641 0.359
E85.9 Amyloidosis, unspecified
0.000 0.642 0.358
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.645 0.354
E26.9 Hyperaldosteronism, unspecified
0.001 0.646 0.354
E26.8 Other hyperaldosteronism
0.001 0.646 0.354
E26.1 Secondary hyperaldosteronism
0.001 0.646 0.354
C43.6 Malignant melanoma of upper limb, including shoulder
0.000 0.648 0.352
E11.8 With unspecified complications
0.000 0.650 0.350
E11.3 With ophthalmic complications
0.000 0.650 0.350
E85.8 Other amyloidosis
0.000 0.653 0.347
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.653 0.347
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.653 0.347
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.653 0.347
C43.5 Malignant melanoma of trunk
0.000 0.653 0.347
E21.4 Other specified disorders of parathyroid gland
0.000 0.655 0.345
E21.2 Other hyperparathyroidism
0.000 0.655 0.345
E44.1 Mild protein-energy malnutrition
0.000 0.657 0.343
E44.0 Moderate protein-energy malnutrition
0.000 0.657 0.343
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.660 0.340
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.660 0.340
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.660 0.340
E74.2 Disorders of galactose metabolism
0.001 0.660 0.340
E74.1 Disorders of fructose metabolism
0.001 0.660 0.340
E74.0 Glycogen storage disease
0.001 0.660 0.340
C43 Malignant melanoma of skin
0.000 0.660 0.340
E61.9 Deficiency of nutrient element, unspecified
0.000 0.664 0.336
E61.8 Deficiency of other specified nutrient elements
0.000 0.664 0.336
E61.7 Deficiency of multiple nutrient elements
0.000 0.664 0.336
E61.6 Vanadium deficiency
0.000 0.664 0.336
E61.5 Molybdenum deficiency
0.000 0.664 0.336
E61.4 Chromium deficiency
0.000 0.664 0.336
E61.3 Manganese deficiency
0.000 0.664 0.336
E61.0 Copper deficiency
0.000 0.664 0.336
E53.1 Pyridoxine deficiency
0.000 0.667 0.333
E53.0 Riboflavin deficiency
0.000 0.667 0.333
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.673 0.327
E27.2 Addisonian crisis
0.000 0.675 0.325
E61.2 Magnesium deficiency
0.000 0.681 0.319
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.683 0.317
K90.3 Pancreatic steatorrhoea
0.001 0.687 0.312
K90.2 Blind loop syndrome, not elsewhere classified
0.001 0.687 0.312
K90.1 Tropical sprue
0.001 0.687 0.312
E11.5 With peripheral circulatory complications
0.000 0.695 0.305
E88.2 Lipomatosis, not elsewhere classified
0.000 0.700 0.300
E61.1 Iron deficiency
0.000 0.700 0.299
E83.3 Disorders of phosphorus metabolism
0.281 0.703 0.016
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.704 0.296
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.704 0.296
E70.3 Albinism
0.001 0.704 0.296
E70.2 Disorders of tyrosine metabolism
0.001 0.704 0.296
E70.1 Other hyperphenylalaninaemias
0.001 0.704 0.296
E70.0 Classical phenylketonuria
0.001 0.704 0.296
E71.3 Disorders of fatty-acid metabolism
0.001 0.704 0.296
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.704 0.296
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.704 0.296
E71.0 Maple-syrup-urine disease
0.001 0.704 0.296
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.704 0.296
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.704 0.296
E72.5 Disorders of glycine metabolism
0.001 0.704 0.296
E72.4 Disorders of ornithine metabolism
0.001 0.704 0.296
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.704 0.296
E72.2 Disorders of urea cycle metabolism
0.001 0.704 0.296
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.704 0.296
E72.0 Disorders of amino-acid transport
0.001 0.704 0.296
E75.6 Lipid storage disorder, unspecified
0.001 0.704 0.296
E75.5 Other lipid storage disorders
0.001 0.704 0.296
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.704 0.296
E75.3 Sphingolipidosis, unspecified
0.001 0.704 0.296
E75.2 Other sphingolipidosis
0.001 0.704 0.296
E75.1 Other gangliosidosis
0.001 0.704 0.296
E75.0 GM2 gangliosidosis
0.001 0.704 0.296
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.704 0.296
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.704 0.296
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.704 0.296
E76.2 Other mucopolysaccharidoses
0.001 0.704 0.296
E76.1 Mucopolysaccharidosis, type II
0.001 0.704 0.296
E76.0 Mucopolysaccharidosis, type I
0.001 0.704 0.296
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.704 0.296
E77.8 Other disorders of glycoprotein metabolism
0.001 0.704 0.296
E77.1 Defects in glycoprotein degradation
0.001 0.704 0.296
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.704 0.296
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.704 0.296
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.704 0.296
E79.1 Lesch-Nyhan syndrome
0.001 0.704 0.296
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.704 0.296
E21.3 Hyperparathyroidism, unspecified
0.000 0.705 0.295
E73.8 Other lactose intolerance
0.001 0.711 0.288
E73.1 Secondary lactase deficiency
0.001 0.711 0.288
E73.0 Congenital lactase deficiency
0.001 0.711 0.288
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.711 0.288
E84.8 Cystic fibrosis with other manifestations
0.001 0.713 0.286
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.713 0.286
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.713 0.286
C43.4 Malignant melanoma of scalp and neck
0.000 0.715 0.285
E06.3 Autoimmune thyroiditis
0.000 0.717 0.283
E83.9 Disorder of mineral metabolism, unspecified
0.247 0.719 0.034
E83.8 Other disorders of mineral metabolism
0.247 0.719 0.034
E83.2 Disorders of zinc metabolism
0.247 0.719 0.034
E83.0 Disorders of copper metabolism
0.247 0.719 0.034
E73.9 Lactose intolerance, unspecified
0.001 0.721 0.278
E03.8 Other specified hypothyroidism
0.000 0.721 0.278
E88.1 Lipodystrophy, not elsewhere classified
0.001 0.723 0.277
E67 Other hyperalimentation
0.000 0.723 0.277
E68 Sequelae of hyperalimentation
0.000 0.723 0.277
E84.9 Cystic fibrosis, unspecified
0.001 0.726 0.273
E88.9 Metabolic disorder, unspecified
0.001 0.727 0.272
C43.9 Malignant melanoma of skin, unspecified
0.000 0.732 0.268
K90.9 Intestinal malabsorption, unspecified
0.001 0.735 0.264
K90.8 Other intestinal malabsorption
0.001 0.737 0.262
C43.3 Malignant melanoma of other and unspecified parts of face
0.000 0.742 0.258
E03.5 Myxoedema coma
0.000 0.743 0.257
E03.4 Atrophy of thyroid (acquired)
0.000 0.743 0.257
E03.3 Postinfectious hypothyroidism
0.000 0.743 0.257
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.743 0.257
E78.8 Other disorders of lipoprotein metabolism
0.000 0.746 0.253
E03.1 Congenital hypothyroidism without goitre
0.000 0.749 0.251
I83 Varicose veins of lower extremities
0.246 0.754 0.000
C43.8 Overlapping malignant melanoma of skin
0.000 0.756 0.244
C43.0 Malignant melanoma of lip
0.000 0.756 0.244
E65 Localised adiposity
0.000 0.757 0.243
E88.3 Tumour lysis syndrome
0.001 0.765 0.235
E11.4 With neurological complications
0.000 0.772 0.228
I83.0 Varicose veins of lower extremities with ulcer
0.224 0.776 0.000
E83.4 Disorders of magnesium metabolism
0.206 0.780 0.015
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.783 0.216
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.783 0.216
C43.1 Malignant melanoma of eyelid, including canthus
0.000 0.791 0.209
E88.8 Other specified metabolic disorders
0.001 0.792 0.207
E67.8 Other specified hyperalimentation
0.000 0.801 0.198
E67.3 Hypervitaminosis D
0.000 0.801 0.198
E67.2 Megavitamin-B6 syndrome
0.000 0.801 0.198
E67.1 Hypercarotenaemia
0.000 0.801 0.198
E67.0 Hypervitaminosis A
0.000 0.801 0.198
E26.0 Primary hyperaldosteronism
0.001 0.811 0.187
C43.2 Malignant melanoma of ear and external auricular canal
0.000 0.815 0.185
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.818 0.181
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.001 0.827 0.172
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.158 0.842 0.000
E11.9 Without complications
0.000 0.844 0.156
J38.4 Oedema of larynx
0.137 0.863 0.000
J38.7 Other diseases of larynx
0.137 0.863 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.135 0.865 0.000
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.869 0.130
E80.5 Crigler-Najjar syndrome
0.001 0.869 0.130
E80.3 Defects of catalase and peroxydase
0.001 0.869 0.130
E80.0 Hereditary erythropoietic porphyria
0.001 0.869 0.130
E80.2 Other porphyria
0.001 0.870 0.129
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.001 0.876 0.124
E89.8 Other postprocedural endocrine and metabolic disorders
0.001 0.876 0.124
E89.5 Postprocedural testicular hypofunction
0.001 0.876 0.124
E89.1 Postprocedural hypoinsulinaemia
0.001 0.876 0.124
J38.3 Other diseases of vocal cords
0.122 0.878 0.000
E80.6 Other disorders of bilirubin metabolism
0.001 0.881 0.118
E89.4 Postprocedural ovarian failure
0.001 0.883 0.117
I83.1 Varicose veins of lower extremities with inflammation
0.114 0.886 0.000
E21.0 Primary hyperparathyroidism
0.000 0.886 0.114
E89.2 Postprocedural hypoparathyroidism
0.000 0.887 0.113
J38.0 Paralysis of vocal cords and larynx
0.112 0.888 0.000
C43.7 Malignant melanoma of lower limb, including hip
0.000 0.895 0.104
J38.2 Nodules of vocal cords
0.104 0.896 0.000
E89.3 Postprocedural hypopituitarism
0.000 0.897 0.102
J38.6 Stenosis of larynx
0.102 0.897 0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.001 0.902 0.098
E80.1 Porphyria cutanea tarda
0.001 0.902 0.096
J38.5 Laryngeal spasm
0.082 0.918 0.000
E04 Other non-toxic goitre
0.000 0.919 0.081
E89.0 Postprocedural hypothyroidism
0.000 0.921 0.079
E83.5 Disorders of calcium metabolism
0.058 0.927 0.014
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.070 0.930 0.000
I85 Oesophageal varices
0.069 0.931 0.000
I85.9 Oesophageal varices without bleeding
0.068 0.932 0.000
L40.5 Arthropathic psoriasis
0.000 0.939 0.061
I86 Varicose veins of other sites
0.061 0.939 0.000
E66 Obesity
0.000 0.940 0.060
I87 Other disorders of veins
0.060 0.940 0.000
E04.8 Other specified non-toxic goitre
0.000 0.942 0.058
E53.8 Deficiency of other specified B group vitamins
0.000 0.942 0.058
C43-C44 Melanoma and other malignant neoplasms of skin
0.000 0.943 0.057
I85.0 Oesophageal varices with bleeding
0.054 0.946 0.000
I86.4 Gastric varices
0.051 0.948 0.000
I87.2 Venous insufficiency (chronic) (peripheral)
0.051 0.949 0.000
I86.8 Varicose veins of other specified sites
0.051 0.949 0.000
I86.3 Vulval varices
0.049 0.951 0.000
I87.1 Compression of vein
0.047 0.953 0.000
E66.0 Obesity due to excess calories
0.000 0.954 0.046
J38.1 Polyp of vocal cord and larynx
0.045 0.954 0.000
E04.0 Non-toxic diffuse goitre
0.000 0.954 0.045
E80.4 Gilbert's syndrome
0.001 0.955 0.044
I86.0 Sublingual varices
0.044 0.956 0.000
I88 Nonspecific lymphadenitis
0.044 0.956 0.000
I86.2 Pelvic varices
0.043 0.956 0.000
E66.1 Drug-induced obesity
0.000 0.957 0.043
I87.0 Postphlebitic syndrome
0.043 0.957 0.000
I87.9 Disorder of vein, unspecified
0.042 0.958 0.000
I81 Portal vein thrombosis
0.041 0.959 0.000
I87.8 Other specified disorders of veins
0.041 0.959 0.000
E04.9 Non-toxic goitre, unspecified
0.000 0.961 0.039
I82 Other venous embolism and thrombosis
0.038 0.962 0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.036 0.964 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.965 0.035
I86.1 Scrotal varices
0.034 0.966 0.000
I88.8 Other nonspecific lymphadenitis
0.033 0.967 0.000
K90-K93 Other diseases of the digestive system
0.008 0.967 0.025
I88.1 Chronic lymphadenitis, except mesenteric
0.032 0.968 0.000
I88.0 Nonspecific mesenteric lymphadenitis
0.032 0.968 0.000
I82.3 Embolism and thrombosis of renal vein
0.029 0.970 0.000
I82.0 Budd-Chiari syndrome
0.029 0.971 0.000
I82.8 Embolism and thrombosis of other specified veins
0.029 0.971 0.000
L40 Psoriasis
0.000 0.971 0.029
I82.1 Thrombophlebitis migrans
0.027 0.972 0.000
I89.0 Lymphoedema, not elsewhere classified
0.027 0.973 0.000
I89.9 Non-infective disorder of lymphatic vessels and lymph nodes, unspecified
0.026 0.974 0.000
I89.1 Lymphangitis
0.025 0.975 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.006 0.976 0.018
I88.9 Nonspecific lymphadenitis, unspecified
0.022 0.978 0.000
L40.0 Psoriasis vulgaris
0.000 0.978 0.022
L40.4 Guttate psoriasis
0.000 0.979 0.021
L40.2 Acrodermatitis continua
0.000 0.979 0.021
L40.1 Generalised pustular psoriasis
0.000 0.980 0.020
L40.3 Pustulosis palmaris et plantaris
0.000 0.980 0.020
I82.9 Embolism and thrombosis of unspecified vein
0.019 0.981 0.000
L40.8 Other psoriasis
0.000 0.981 0.019
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.981 0.019
K92.1 Melaena
0.018 0.982 0.000
K92 Other diseases of digestive system
0.017 0.982 0.001
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.004 0.983 0.013
K93.1 Megacolon in Chagas' disease
0.004 0.983 0.013
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.004 0.983 0.013
E86 Volume depletion
0.000 0.983 0.017
L40.9 Psoriasis, unspecified
0.000 0.983 0.017
M07.3 Other psoriatic arthropathies
0.000 0.983 0.017
K92.0 Haematemesis
0.017 0.983 0.000
I82.2 Embolism and thrombosis of vena cava
0.016 0.983 0.000
K92.2 Gastro-intestinal haemorrhage, unspecified
0.016 0.984 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.984 0.016
L30.9 Dermatitis, unspecified
0.016 0.984 0.000
L40-L45 Papulosquamous disorders
0.000 0.985 0.015
D25.9 Leiomyoma of uterus, unspecified
0.015 0.985 0.000
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.986 0.014
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.986 0.014

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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