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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3129907
log Bayes Factor = 216.31
Chromosome 6   position 32,323,745  (GRCh37) Explore rs3129907 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
L40 Psoriasis
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E16.2 Hypoglycaemia, unspecified
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
J33 Nasal polyp
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
J33.0 Polyp of nasal cavity
0.000 0.000 1.000
E16 Other disorders of pancreatic internal secretion
0.000 0.000 1.000
E14.9 Without complications
0.000 0.000 1.000
M35.3 Polymyalgia rheumatica
0.000 0.000 1.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.000 1.000
J33.9 Nasal polyp, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.000 1.000
E11.3 With ophthalmic complications
0.000 0.000 1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
L40-L45 Papulosquamous disorders
0.000 0.000 1.000
E10.4 With neurological complications
0.000 0.001 0.999
H36 Retinal disorders in diseases classified elsewhere
0.000 0.001 0.999
# Top node
0.000 0.001 0.999
I10-I15 Hypertensive diseases
0.000 0.001 0.999
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
I10 Essential (primary) hypertension
0.000 0.001 0.999
H30-H36 Disorders of choroid and retina
0.000 0.001 0.999
E70-E90 Metabolic disorders
0.000 0.001 0.999
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.001 0.999
Chapter IX Diseases of the circulatory system
0.000 0.002 0.998
M07 Psoriatic and enteropathic arthropathies
0.000 0.002 0.998
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.002 0.998
M07.3 Other psoriatic arthropathies
0.000 0.003 0.997
L40.9 Psoriasis, unspecified
0.000 0.003 0.997
G35-G37 Demyelinating diseases of the central nervous system
0.997 0.003 0.000
G37 Other demyelinating diseases of central nervous system
0.997 0.003 0.000
M35 Other systemic involvement of connective tissue
0.000 0.003 0.997
E14.3 With ophthalmic complications
0.000 0.004 0.996
G37.9 Demyelinating disease of central nervous system, unspecified
0.996 0.004 0.000
Chapter VII Diseases of the eye and adnexa
0.000 0.005 0.995
J33.8 Other polyp of sinus
0.000 0.005 0.995
I20-I25 Ischaemic heart diseases
0.000 0.005 0.995
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.006 0.994
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.006 0.994
I22 Subsequent myocardial infarction
0.000 0.006 0.994
M20-M25 Other joint disorders
0.000 0.007 0.993
E11.1 With ketoacidosis
0.000 0.008 0.992
E10.5 With peripheral circulatory complications
0.000 0.009 0.991
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.012 0.988
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.014 0.986
L43 Lichen planus
0.000 0.015 0.985
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.019 0.981
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.027 0.973
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.029 0.971
E10.2 With renal complications
0.000 0.032 0.968
I12 Hypertensive renal disease
0.000 0.033 0.967
L43.9 Lichen planus, unspecified
0.000 0.034 0.966
M06.0 Seronegative rheumatoid arthritis
0.000 0.035 0.965
E06 Thyroiditis
0.000 0.035 0.965
H34 Retinal vascular occlusions
0.000 0.040 0.960
E10.8 With unspecified complications
0.000 0.045 0.955
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.045 0.955
I12.9 Hypertensive renal disease without renal failure
0.000 0.048 0.952
M34 Systemic sclerosis
0.000 0.056 0.944
E06.3 Autoimmune thyroiditis
0.000 0.057 0.943
E10.0 With coma
0.000 0.062 0.938
M06.3 Rheumatoid nodule
0.000 0.063 0.937
M45-M49 Spondylopathies
0.000 0.066 0.934
M45 Ankylosing spondylitis
0.000 0.067 0.933
H35 Other retinal disorders
0.000 0.068 0.932
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.070 0.930
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.074 0.926
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.081 0.919
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.082 0.918
H40-H42 Glaucoma
0.000 0.085 0.915
E78.2 Mixed hyperlipidaemia
0.000 0.092 0.908
H35.4 Peripheral retinal degeneration
0.000 0.095 0.905
E78.1 Pure hyperglyceridaemia
0.000 0.097 0.903
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.100 0.900
M06.4 Inflammatory polyarthropathy
0.000 0.101 0.899
M65-M68 Disorders of synovium and tendon
0.000 0.108 0.892
G37.8 Other specified demyelinating diseases of central nervous system
0.889 0.111 0.000
H35.8 Other specified retinal disorders
0.000 0.112 0.888
E88 Other metabolic disorders
0.000 0.119 0.881
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.120 0.880
E07 Other disorders of thyroid
0.000 0.121 0.879
Chapter VIII Diseases of the ear and mastoid process
0.000 0.129 0.871
E11.2 With renal complications
0.000 0.129 0.871
E11.5 With peripheral circulatory complications
0.000 0.136 0.864
M34.1 CR(E)ST syndrome
0.000 0.137 0.863
H34.8 Other retinal vascular occlusions
0.000 0.140 0.860
M35.7 Hypermobility syndrome
0.000 0.141 0.859
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.141 0.859
M35.1 Other overlap syndromes
0.000 0.142 0.858
H40 Glaucoma
0.000 0.143 0.857
L40.8 Other psoriasis
0.000 0.143 0.857
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.144 0.856
M65 Synovitis and tenosynovitis
0.000 0.144 0.856
H40.9 Glaucoma, unspecified
0.000 0.146 0.854
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.148 0.852
H34.2 Other retinal artery occlusions
0.000 0.157 0.843
L43.8 Other lichen planus
0.000 0.160 0.840
I21 Acute myocardial infarction
0.000 0.160 0.840
H60-H62 Diseases of external ear
0.000 0.161 0.839
M34.9 Systemic sclerosis, unspecified
0.000 0.166 0.834
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.168 0.831
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.171 0.829
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.172 0.828
E10.6 With other specified complications
0.000 0.182 0.818
M06.34 Rheumatoid nodule (Hand)
0.000 0.183 0.817
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.184 0.816
I21.9 Acute myocardial infarction, unspecified
0.000 0.188 0.812
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.188 0.812
M65.4 Radial styloid tenosynovitis [de Quervain]
0.000 0.190 0.810
I15 Secondary hypertension
0.000 0.191 0.809
M65.9 Synovitis and tenosynovitis, unspecified
0.000 0.192 0.808
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.198 0.802
E11.8 With unspecified complications
0.000 0.199 0.801
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.201 0.799
H61 Other disorders of external ear
0.000 0.204 0.796
E14.4 With neurological complications
0.000 0.207 0.793
H43-H45 Disorders of vitreous body and globe
0.000 0.211 0.789
M31 Other necrotising vasculopathies
0.000 0.211 0.789
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.218 0.782
M30 Polyarteritis nodosa and related conditions
0.000 0.224 0.776
E74 Other disorders of carbohydrate metabolism
0.000 0.224 0.776
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.225 0.775
E07.9 Disorder of thyroid, unspecified
0.000 0.228 0.771
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.230 0.770
E03.8 Other specified hypothyroidism
0.000 0.233 0.767
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.233 0.767
M35.2 Behcet's disease
0.000 0.235 0.765
E83 Disorders of mineral metabolism
0.283 0.236 0.481
M86-M90 Other osteopathies
0.000 0.239 0.761
H35.6 Retinal haemorrhage
0.000 0.241 0.759
I22.8 Subsequent myocardial infarction of other sites
0.000 0.242 0.758
E14.5 With peripheral circulatory complications
0.000 0.246 0.754
H35.7 Separation of retinal layers
0.000 0.250 0.750
H61.0 Perichondritis of external ear
0.000 0.251 0.749
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)
0.000 0.253 0.747
M14 Arthropathies in other diseases classified elsewhere
0.000 0.254 0.746
H34.1 Central retinal artery occlusion
0.000 0.255 0.745
I11 Hypertensive heart disease
0.000 0.256 0.744
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.257 0.743
L40.0 Psoriasis vulgaris
0.000 0.258 0.742
H34.9 Retinal vascular occlusion, unspecified
0.000 0.266 0.734
E14.2 Withrenal complications
0.000 0.266 0.734
E89.0 Postprocedural hypothyroidism
0.000 0.267 0.733
L40.3 Pustulosis palmaris et plantaris
0.000 0.267 0.733
G36 Other acute disseminated demyelination
0.729 0.271 0.000
I00-I02 Acute rheumatic fever
0.000 0.273 0.727
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.275 0.725
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.724 0.276 0.000
H43 Disorders of vitreous body
0.000 0.277 0.723
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.282 0.718
H65-H75 Diseases of middle ear and mastoid
0.000 0.282 0.718
E11.6 With other specified complications
0.000 0.283 0.717
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.6 With other specified complications
0.000 0.283 0.717
E14.1 With ketoacidosis
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
J33.1 Polypoid sinus degeneration
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.2 Rheumatoid vasculitis
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.283 0.717
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.283 0.717
E16.4 Abnormal secretion of gastrin
0.000 0.283 0.717
E16.3 Increased secretion of glucagon
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E78.6 Lipoprotein deficiency
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.283 0.717
L44 Other papulosquamous disorders
0.000 0.283 0.717
L41 Parapsoriasis
0.000 0.283 0.717
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.283 0.717
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.283 0.716
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.716
I13 Hypertensive heart and renal disease
0.000 0.283 0.716
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.284 0.716
E77 Disorders of glycoprotein metabolism
0.000 0.284 0.716
E76 Disorders of glycosaminoglycan metabolism
0.000 0.284 0.716
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.284 0.716
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.284 0.716
M86 Osteomyelitis
0.000 0.284 0.716
M07.5 Arthropathy in ulcerative colitis
0.000 0.284 0.716
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.284 0.716
M07.2 Psoriatic spondylitis
0.000 0.284 0.716
M07.1 Arthritis mutilans
0.000 0.284 0.716
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.284 0.716
M07.38 Other psoriatic arthropathies (Other)
0.000 0.285 0.715
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.285 0.715
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.285 0.715
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.285 0.715
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.285 0.715
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.285 0.715
G37.5 Concentric sclerosis [Balo]
0.715 0.285 0.000
G37.4 Subacute necrotising myelitis
0.715 0.285 0.000
G37.2 Central pontine myelinolysis
0.715 0.285 0.000
G37.1 Central demyelination of corpus callosum
0.715 0.285 0.000
G37.0 Diffuse sclerosis
0.715 0.285 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.285 0.715
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.285 0.715
M35.5 Multifocal fibrosclerosis
0.000 0.285 0.715
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.285 0.715
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.286 0.714
H60 Otitis externa
0.000 0.287 0.713
H30 Chorioretinal inflammation
0.000 0.288 0.712
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.288 0.712
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.288 0.712
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.289 0.711
M65.90 Synovitis and tenosynovitis, unspecified (Multiple sites)
0.000 0.292 0.708
L43.3 Subacute (active) lichen planus
0.000 0.293 0.706
L43.2 Lichenoid drug reaction
0.000 0.293 0.706
L43.1 Bullous lichen planus
0.000 0.293 0.706
L43.0 Hypertrophic lichen planus
0.000 0.293 0.706
M65.94 Synovitis and tenosynovitis, unspecified (Hand)
0.000 0.294 0.706
E13 Other specified diabetes mellitus
0.000 0.294 0.706
E88.2 Lipomatosis, not elsewhere classified
0.000 0.297 0.703
E88.8 Other specified metabolic disorders
0.000 0.298 0.702
E70 Disorders of aromatic amino-acid metabolism
0.000 0.299 0.701
E78.4 Other hyperlipidaemia
0.000 0.302 0.697
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.305 0.695
E79 Disorders of purine and pyrimidine metabolism
0.000 0.307 0.693
M49 Spondylopathies in diseases classified elsewhere
0.000 0.307 0.693
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.308 0.692
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.308 0.692
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.308 0.692
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.308 0.692
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.308 0.692
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.308 0.692
E40-E46 Malnutrition
0.000 0.308 0.692
E06.5 Other chronic thyroiditis
0.000 0.308 0.692
E06.4 Drug-induced thyroiditis
0.000 0.308 0.692
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.308 0.692
E06.1 Subacute thyroiditis
0.000 0.308 0.692
E06.0 Acute thyroiditis
0.000 0.308 0.692
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)
0.000 0.308 0.692
H61.1 Non-infective disorders of pinna
0.000 0.309 0.691
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)
0.000 0.310 0.690
H40.4 Glaucoma secondary to eye inflammation
0.000 0.310 0.690
H34.0 Transient retinal artery occlusion
0.000 0.312 0.688
H33 Retinal detachments and breaks
0.000 0.312 0.688
M86.9 Osteomyelitis, unspecified
0.000 0.312 0.687
E16.1 Other hypoglycaemia
0.000 0.316 0.684
H61.8 Other specified disorders of external ear
0.000 0.318 0.681
I24 Other acute ischaemic heart diseases
0.000 0.319 0.681
M65.93 Synovitis and tenosynovitis, unspecified (Forearm)
0.000 0.320 0.680
E07.8 Other specified disorders of thyroid
0.000 0.320 0.680
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.323 0.677
M34.0 Progressive systemic sclerosis
0.000 0.323 0.677
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.323 0.677
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.324 0.676
H35.2 Other proliferative retinopathy
0.000 0.325 0.675
M86.97 Osteomyelitis, unspecified (Ankle and foot)
0.000 0.326 0.674
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.328 0.672
M06.38 Rheumatoid nodule (Other)
0.000 0.328 0.672
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.328 0.672
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.328 0.672
M06.33 Rheumatoid nodule (Forearm)
0.000 0.328 0.672
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.328 0.672
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.328 0.672
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.330 0.670
M07.6 Other enteropathic arthropathies
0.000 0.330 0.670
M65.1 Other infective (teno)synovitis
0.000 0.330 0.670
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.331 0.669
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.331 0.669
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.331 0.669
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.331 0.669
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.331 0.669
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.331 0.669
H35.1 Retinopathy of prematurity
0.000 0.331 0.668
M34.8 Other forms of systemic sclerosis
0.000 0.332 0.667
M31.6 Other giant cell arteritis
0.000 0.333 0.667
M10 Gout
0.000 0.334 0.666
E72 Other disorders of amino-acid metabolism
0.000 0.340 0.660
E84 Cystic fibrosis
0.000 0.342 0.658
M32 Systemic lupus erythematosus
0.000 0.342 0.658
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.343 0.656
H42 Glaucoma in diseases classified elsewhere
0.000 0.344 0.656
M80-M85 Disorders of bone density and structure
0.000 0.345 0.655
M12 Other specific arthropathies
0.000 0.347 0.653
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.347 0.653
M91-M94 Chondropathies
0.000 0.352 0.648
I15.1 Hypertension secondary to other renal disorders
0.000 0.352 0.648
E06.9 Thyroiditis, unspecified
0.000 0.352 0.648
M65.92 Synovitis and tenosynovitis, unspecified (Upper arm)
0.000 0.352 0.648
L10-L14 Bullous disorders
0.000 0.354 0.646
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.355 0.645
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.355 0.645
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.355 0.645
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.355 0.645
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.355 0.645
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.355 0.645
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.355 0.645
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.355 0.645
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.360 0.640
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.000 0.361 0.639
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.362 0.638
H33.3 Retinal breaks without detachment
0.000 0.364 0.636
E88.3 Tumour lysis syndrome
0.000 0.364 0.636
E88.9 Metabolic disorder, unspecified
0.000 0.369 0.631
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.369 0.631
E07.1 Dyshormogenetic goitre
0.000 0.369 0.630
E07.0 Hypersecretion of calcitonin
0.000 0.369 0.630
H72 Perforation of tympanic membrane
0.000 0.374 0.626
I15.9 Seconday hypertension, unspecified
0.000 0.374 0.626
E11.4 With neurological complications
0.000 0.378 0.622
M11 Other crystal arthropathies
0.000 0.378 0.622
L42 Pityriasis rosea
0.000 0.380 0.620
M31.3 Wegener's granulomatosis
0.000 0.380 0.620
M65.95 Synovitis and tenosynovitis, unspecified (Pelvic region and thigh)
0.000 0.381 0.618
L80 Vitiligo
0.000 0.382 0.618
H60.3 Other infective otitis externa
0.000 0.382 0.618
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.383 0.617
H43.3 Other vitreous opacities
0.000 0.385 0.615
H40.6 Glaucoma secondary to drugs
0.000 0.385 0.614
H40.3 Glaucoma secondary to eye trauma
0.000 0.385 0.614
M65.2 Calcific tendinitis
0.000 0.386 0.614
M65.0 Abscess of tendon sheath
0.000 0.386 0.614
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.387 0.613
E05.8 Other thyrotoxicosis
0.000 0.388 0.612
D64.9 Anaemia, unspecified
0.000 0.388 0.612
I23 Certain current complications following acute myocardial infarction
0.000 0.389 0.611
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.392 0.608
M66 Spontaneous rupture of synovium and tendon
0.000 0.394 0.606
M14.6 Neuropathic arthropathy
0.000 0.394 0.606
H40.5 Glaucoma secondary to other eye disorders
0.000 0.394 0.606
H43.9 Disorder of vitreous body, unspecified
0.000 0.396 0.604
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.396 0.603
E11.0 With coma
0.000 0.397 0.603
D64 Other anaemias
0.000 0.397 0.603
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.398 0.602
I05-I09 Chronic rheumatic heart diseases
0.000 0.398 0.602
D60-D64 Aplastic and other anaemias
0.000 0.398 0.602
H62 Disorders of external ear in diseases classified elsewhere
0.000 0.398 0.602
I70 Atherosclerosis
0.000 0.400 0.600
E89.4 Postprocedural ovarian failure
0.000 0.400 0.600
M33 Dermatopolymyositis
0.000 0.405 0.595
E73 Lactose intolerance
0.000 0.405 0.595
M82 Osteoporosis in diseases classified elsewhere
0.000 0.405 0.595
H73 Other disorders of tympanic membrane
0.000 0.406 0.594
M35.0 Sicca syndrome [Sjogren]
0.000 0.406 0.594
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.407 0.592
M30.0 Polyarteritis nodosa
0.000 0.408 0.592
M30.1 Polyarteritis with lung involvement [Churg-Strauss]
0.000 0.408 0.592
M65.99 Synovitis and tenosynovitis, unspecified (Site unspecified)
0.000 0.410 0.590
L85 Other epidermal thickening
0.000 0.417 0.583
M80 Osteoporosis with pathological fracture
0.000 0.418 0.582
L20-L30 Dermatitis and eczema
0.000 0.419 0.581
M65.49 Radial styloid tenosynovitis [de Quervain]-Site unspec
0.000 0.419 0.581
M65.48 Radial styloid tenosynovitis [de Quervain]-Other
0.000 0.419 0.581
M65.47 Radial styloid tenosynovitis [de Quervain]-Ankle/foot
0.000 0.419 0.581
M65.46 Radial styloid tenosynovitis [de Quervain]-Lower leg
0.000 0.419 0.581
M65.45 Radial styloid tenosynovitis [de Quervain]-Pelvic/thigh
0.000 0.419 0.581
M65.42 Radial styloid tenosynovitis [de Quervain]-Upper arm
0.000 0.419 0.581
M65.41 Radial styloid tenosynovitis [de Quervain]-Shldr region
0.000 0.419 0.581
M65.40 Radial styloid tenosynovitis [de Quervain] (Multiple sites)
0.000 0.419 0.581
I15.8 Other secondary hypertension
0.000 0.420 0.580
I15.2 Hypertension secondary to endocrine disorders
0.000 0.420 0.580
M65.98 Synovitis and tenosynovitis, unspecified (Other)
0.000 0.420 0.580
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.421 0.578
H40.1 Primary open-angle glaucoma
0.000 0.422 0.578
M31.9 Necrotising vasculopathy, unspecified
0.000 0.423 0.577
M31.1 Thrombotic microangiopathy
0.000 0.426 0.574
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.427 0.573
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.427 0.573
E89.5 Postprocedural testicular hypofunction
0.000 0.427 0.573
E89.1 Postprocedural hypoinsulinaemia
0.000 0.427 0.573
M00-M03 Infectious arthropathies
0.000 0.427 0.572
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.000 0.428 0.572
E78.8 Other disorders of lipoprotein metabolism
0.000 0.431 0.568
I15.0 Renovascular hypertension
0.000 0.432 0.568
H43.8 Other disorders of vitreous body
0.000 0.432 0.568
H60.9 Otitis externa, unspecified
0.000 0.433 0.567
E65-E68 Obesity and other hyperalimentation
0.000 0.433 0.567
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.434 0.566
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.434 0.566
M31.8 Other specified necrotising vasculopathies
0.000 0.434 0.566
M31.7 Microscopic polyangiitis
0.000 0.434 0.566
M31.4 Aortic arch syndrome [Takayasu]
0.000 0.434 0.566
M31.2 Lethal midline granuloma
0.000 0.434 0.566
M88 Paget's disease of bone [osteitis deformans]
0.000 0.435 0.565
E03.1 Congenital hypothyroidism without goitre
0.000 0.436 0.563
H35.5 Hereditary retinal dystrophy
0.000 0.437 0.562
L28 Lichen simplex chronicus and prurigo
0.000 0.438 0.562
M60-M63 Disorders of muscles
0.000 0.440 0.560
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.440 0.560
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.442 0.558
M30.8 Other conditions related to polyarteritis nodosa
0.000 0.443 0.557
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]
0.000 0.443 0.557
M30.2 Juvenile polyarteritis
0.000 0.443 0.557
H46 Optic neuritis
0.000 0.443 0.557
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.443 0.556
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.443 0.556
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.443 0.556
E74.2 Disorders of galactose metabolism
0.000 0.443 0.556
E74.1 Disorders of fructose metabolism
0.000 0.443 0.556
E74.0 Glycogen storage disease
0.000 0.443 0.556
H72.0 Central perforation of tympanic membrane
0.000 0.445 0.555
I12.0 Hypertensive renal disease with renal failure
0.000 0.445 0.555
H33.4 Traction detachment of retina
0.000 0.447 0.553
M82.1 Osteoporosis in endocrine disorders
0.000 0.448 0.552
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.449 0.551
L85.8 Other specified epidermal thickening
0.000 0.451 0.549
E83.8 Other disorders of mineral metabolism
0.203 0.452 0.345
E83.2 Disorders of zinc metabolism
0.203 0.452 0.345
E83.0 Disorders of copper metabolism
0.203 0.452 0.345
H43.2 Crystalline deposits in vitreous body
0.000 0.453 0.547
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.000 0.453 0.546
H66 Suppurative and unspecified otitis media
0.000 0.454 0.546
M80.9 Unspecified osteoporosis with pathological fracture
0.000 0.457 0.543
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.457 0.543
H61.3 Acquired stenosis of external ear canal
0.000 0.458 0.542
M90 Osteopathies in diseases classified elsewhere
0.000 0.458 0.541
M86.6 Other chronic osteomyelitis
0.000 0.459 0.541
H61.9 Disorder of external ear, unspecified
0.000 0.459 0.541
M86.98 Osteomyelitis, unspecified (Other)
0.000 0.459 0.540
L28.0 Lichen simplex chronicus
0.000 0.460 0.540
H47 Other disorders of optic [2nd] nerve and visual pathways
0.000 0.460 0.540
H74 Other disorders of middle ear and mastoid
0.000 0.462 0.538
G36.0 Neuromyelitis optica [Devic]
0.537 0.463 0.000
H60.5 Acute otitis externa, non-infective
0.000 0.463 0.537
M65.14 Other infective (teno)synovitis (Hand)
0.000 0.464 0.536
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders
0.000 0.465 0.535
M14.4 Arthropathy in amyloidosis
0.000 0.465 0.535
M14.3 Lipoid dermatoarthritis
0.000 0.465 0.535
M14.2 Diabetic arthropathy
0.000 0.465 0.535
M14.1 Crystal arthropathy in other metabolic disorders
0.000 0.465 0.535
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders
0.000 0.465 0.535
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere
0.000 0.467 0.533
H65 Nonsuppurative otitis media
0.000 0.467 0.533
I00 Rheumatic fever without mention of heart involvement
0.000 0.467 0.532
H60.4 Cholesteatoma of external ear
0.000 0.468 0.532
H66.3 Other chronic suppurative otitis media
0.000 0.470 0.530
L83 Acanthosis nigricans
0.000 0.471 0.529
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.000 0.472 0.527
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.473 0.527
E89.3 Postprocedural hypopituitarism
0.000 0.473 0.527
H72.9 Perforation of tympanic membrane, unspecified
0.000 0.474 0.526
I70.0 Atherosclerosis of aorta
0.000 0.474 0.526
E83.9 Disorder of mineral metabolism, unspecified
0.220 0.474 0.306
G36.9 Acute disseminated demyelination, unspecified
0.523 0.477 0.000
G36.8 Other specified acute disseminated demyelination
0.523 0.477 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.523 0.477 0.000
E13.9 Without complications
0.000 0.478 0.522
I02 Rheumatic chorea
0.000 0.479 0.521
I01 Rheumatic fever with heart involvement
0.000 0.479 0.521
I20 Angina pectoris
0.000 0.480 0.520
M49.5 Collapsed vertebra in diseases classified elsewhere
0.000 0.480 0.520
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.481 0.519
H04 Disorders of lachrymal system
0.000 0.481 0.519

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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