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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3130054
log Bayes Factor = 62.5776
Chromosome 6   position 31,496,776  (GRCh37) Explore rs3130054 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.004 0.996
I25.1 Atherosclerotic heart disease
0.000 0.005 0.995
E14.9 Without complications
0.000 0.007 0.993
E14.3 With ophthalmic complications
0.000 0.009 0.991
E10.1 With ketoacidosis
0.000 0.011 0.989
I25.5 Ischaemic cardiomyopathy
0.000 0.012 0.988
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.012 0.988
I20 Angina pectoris
0.000 0.013 0.987
E10.4 With neurological complications
0.000 0.017 0.983
I22 Subsequent myocardial infarction
0.000 0.020 0.980
I20.9 Angina pectoris, unspecified
0.000 0.033 0.967
G35-G37 Demyelinating diseases of the central nervous system
0.966 0.034 0.000
G37 Other demyelinating diseases of central nervous system
0.960 0.040 0.000
I20.0 Unstable angina
0.000 0.044 0.956
E83.1 Disorders of iron metabolism
0.956 0.044 0.000
I25.2 Old myocardial infarction
0.000 0.044 0.956
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.052 0.948
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.057 0.943
G37.9 Demyelinating disease of central nervous system, unspecified
0.942 0.058 0.000
E13 Other specified diabetes mellitus
0.000 0.071 0.929
I24 Other acute ischaemic heart diseases
0.000 0.073 0.927
E10.2 With renal complications
0.000 0.115 0.885
I10 Essential (primary) hypertension
0.000 0.118 0.882
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.120 0.880
I21 Acute myocardial infarction
0.000 0.122 0.878
E13.9 Without complications
0.000 0.122 0.878
E11.2 With renal complications
0.000 0.136 0.864
L40-L45 Papulosquamous disorders
0.000 0.138 0.862
E78.8 Other disorders of lipoprotein metabolism
0.000 0.140 0.860
E11.0 With coma
0.000 0.146 0.854
I25.3 Aneurysm of heart
0.000 0.149 0.851
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.150 0.850
E70-E90 Metabolic disorders
0.000 0.157 0.842
G37.8 Other specified demyelinating diseases of central nervous system
0.841 0.159 0.000
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.159 0.841
E11.1 With ketoacidosis
0.000 0.160 0.840
I10-I15 Hypertensive diseases
0.000 0.172 0.828
L43 Lichen planus
0.000 0.173 0.827
L40.8 Other psoriasis
0.000 0.173 0.827
E14.4 With neurological complications
0.000 0.174 0.826
E10.8 With unspecified complications
0.000 0.178 0.822
R07.4 Chest pain, unspecified
0.000 0.181 0.819
I21.9 Acute myocardial infarction, unspecified
0.000 0.187 0.813
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.191 0.809
E10.5 With peripheral circulatory complications
0.000 0.197 0.803
E10.0 With coma
0.000 0.204 0.796
L40.0 Psoriasis vulgaris
0.000 0.208 0.792
L43.9 Lichen planus, unspecified
0.000 0.212 0.788
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.786 0.214 0.000
E11.6 With other specified complications
0.000 0.225 0.775
E78.2 Mixed hyperlipidaemia
0.000 0.227 0.773
I21.4 Acute subendocardial myocardial infarction
0.000 0.230 0.770
I23 Certain current complications following acute myocardial infarction
0.000 0.231 0.769
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.238 0.762
I24.8 Other forms of acute ischaemic heart disease
0.000 0.242 0.758
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.244 0.755
E10.6 With other specified complications
0.000 0.264 0.736
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.264 0.736
E14.5 With peripheral circulatory complications
0.000 0.265 0.735
I12 Hypertensive renal disease
0.000 0.269 0.731
I15 Secondary hypertension
0.000 0.274 0.726
E14.6 With other specified complications
0.000 0.277 0.723
E78.6 Lipoprotein deficiency
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.2 Withrenal complications
0.000 0.283 0.717
E14.1 With ketoacidosis
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
E11.5 With peripheral circulatory complications
0.000 0.288 0.712
E78.5 Hyperlipidaemia, unspecified
0.000 0.297 0.703
G36 Other acute disseminated demyelination
0.695 0.304 0.000
E78.1 Pure hyperglyceridaemia
0.000 0.309 0.691
G37.5 Concentric sclerosis [Balo]
0.688 0.312 0.000
G37.4 Subacute necrotising myelitis
0.688 0.312 0.000
G37.2 Central pontine myelinolysis
0.688 0.312 0.000
G37.1 Central demyelination of corpus callosum
0.688 0.312 0.000
G37.0 Diffuse sclerosis
0.688 0.312 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.312 0.688
L40.3 Pustulosis palmaris et plantaris
0.000 0.316 0.684
E85 Amyloidosis
0.000 0.316 0.684
L43.8 Other lichen planus
0.000 0.321 0.678
E78.3 Hyperchylomicronaemia
0.000 0.324 0.676
I22.8 Subsequent myocardial infarction of other sites
0.000 0.330 0.670
I12.9 Hypertensive renal disease without renal failure
0.000 0.332 0.668
E13.8 With unspecified complications
0.000 0.334 0.666
E13.7 With multiple complications
0.000 0.334 0.666
E13.6 With other specified complications
0.000 0.334 0.666
E13.5 With peripheral circulatory complications
0.000 0.334 0.666
E13.4 With neurological complications
0.000 0.334 0.666
E13.3 With ophthalmic complications
0.000 0.334 0.666
E13.2 With renal complications
0.000 0.334 0.666
E13.1 With ketoacidosis
0.000 0.334 0.666
E13.0 With coma
0.000 0.334 0.666
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.337 0.663
E74 Other disorders of carbohydrate metabolism
0.000 0.341 0.659
L42 Pityriasis rosea
0.000 0.343 0.657
I15.1 Hypertension secondary to other renal disorders
0.000 0.343 0.657
E00-E07 Disorders of thyroid gland
0.000 0.343 0.657
E11.4 With neurological complications
0.000 0.352 0.648
E78.4 Other hyperlipidaemia
0.000 0.354 0.646
I11 Hypertensive heart disease
0.000 0.356 0.644
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.370 0.629
E16.2 Hypoglycaemia, unspecified
0.000 0.373 0.627
L44 Other papulosquamous disorders
0.000 0.382 0.618
L41 Parapsoriasis
0.000 0.382 0.618
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.382 0.618
E79 Disorders of purine and pyrimidine metabolism
0.000 0.394 0.605
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.394 0.606
I20.1 Angina pectoris with documented spasm
0.000 0.396 0.604
E77 Disorders of glycoprotein metabolism
0.000 0.396 0.604
E76 Disorders of glycosaminoglycan metabolism
0.000 0.396 0.604
E72 Other disorders of amino-acid metabolism
0.000 0.396 0.604
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.396 0.604
E70 Disorders of aromatic amino-acid metabolism
0.000 0.396 0.604
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.396 0.604
I23.8 Other current complications following acute myocardial infarction
0.000 0.396 0.604
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.403 0.596
E03 Other hypothyroidism
0.000 0.406 0.594
I13 Hypertensive heart and renal disease
0.000 0.406 0.593
L43.3 Subacute (active) lichen planus
0.000 0.407 0.593
L43.2 Lichenoid drug reaction
0.000 0.407 0.593
L43.1 Bullous lichen planus
0.000 0.407 0.593
L43.0 Hypertrophic lichen planus
0.000 0.407 0.593
I25.4 Coronary artery aneurysm
0.000 0.414 0.585
E05.9 Thyrotoxicosis, unspecified
0.000 0.422 0.578
E85.9 Amyloidosis, unspecified
0.000 0.424 0.576
E03.9 Hypothyroidism, unspecified
0.000 0.427 0.573
E84 Cystic fibrosis
0.000 0.446 0.554
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.448 0.551
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.448 0.551
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.448 0.551
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.448 0.551
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.448 0.551
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.448 0.551
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.448 0.551
Chapter IX Diseases of the circulatory system
0.000 0.454 0.546
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.457 0.543
E15 Nondiabetic hypoglycaemic coma
0.000 0.458 0.542
E40-E46 Malnutrition
0.000 0.459 0.541
E16.1 Other hypoglycaemia
0.000 0.464 0.536
I24.1 Dressler's syndrome
0.000 0.470 0.530
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.472 0.528
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.476 0.524
I15.8 Other secondary hypertension
0.000 0.479 0.521
I15.2 Hypertension secondary to endocrine disorders
0.000 0.479 0.521
I15.0 Renovascular hypertension
0.000 0.479 0.521
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.483 0.517
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
I15.9 Seconday hypertension, unspecified
0.000 0.488 0.512
I12.0 Hypertensive renal disease with renal failure
0.000 0.492 0.508
E11.8 With unspecified complications
0.000 0.495 0.505
G36.0 Neuromyelitis optica [Devic]
0.501 0.498 0.000
G36.9 Acute disseminated demyelination, unspecified
0.499 0.501 0.000
G36.8 Other specified acute disseminated demyelination
0.499 0.501 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.499 0.501 0.000
E73 Lactose intolerance
0.001 0.505 0.494
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.507 0.493
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.507 0.493
E16.4 Abnormal secretion of gastrin
0.000 0.507 0.493
E16.3 Increased secretion of glucagon
0.000 0.507 0.493
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.509 0.491
E85.8 Other amyloidosis
0.000 0.509 0.490
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.509 0.490
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.509 0.490
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.509 0.490
E85.4 Organ-limited amyloidosis
0.000 0.512 0.488
E11.3 With ophthalmic complications
0.000 0.512 0.488
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.518 0.482
E85.3 Secondary systemic amyloidosis
0.000 0.519 0.481
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.522 0.478
E83 Disorders of mineral metabolism
0.367 0.524 0.109
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.527 0.473
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.527 0.473
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.527 0.473
E74.2 Disorders of galactose metabolism
0.000 0.527 0.473
E74.1 Disorders of fructose metabolism
0.000 0.527 0.473
E74.0 Glycogen storage disease
0.000 0.527 0.473
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.529 0.471
E00 Congenital iodine-deficiency syndrome
0.000 0.529 0.471
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.534 0.466
E89.3 Postprocedural hypopituitarism
0.000 0.549 0.450
L41.9 Parapsoriasis, unspecified
0.000 0.557 0.443
L41.8 Other parapsoriasis
0.000 0.557 0.443
L41.5 Retiform parapsoriasis
0.000 0.557 0.443
L41.4 Large plaque parapsoriasis
0.000 0.557 0.443
L41.3 Small plaque parapsoriasis
0.000 0.557 0.443
L41.2 Lymphomatoid papulosis
0.000 0.557 0.443
L41.1 Pityriasis lichenoides chronica
0.000 0.557 0.443
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.557 0.443
L44.9 Papulosquamous disorder, unspecified
0.000 0.557 0.443
L44.8 Other specified papulosquamous disorders
0.000 0.557 0.443
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.557 0.443
L44.3 Lichen ruber moniliformis
0.000 0.557 0.443
L44.2 Lichen striatus
0.000 0.557 0.443
L44.1 Lichen nitidus
0.000 0.557 0.443
L44.0 Pityriasis rubra pilaris
0.000 0.557 0.443
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.564 0.436
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.565 0.434
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.565 0.434
E79.1 Lesch-Nyhan syndrome
0.000 0.565 0.434
E05.5 Thyroid crisis or storm
0.000 0.566 0.434
E05.4 Thyrotoxicosis factitia
0.000 0.566 0.434
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.566 0.434
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.566 0.434
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.567 0.433
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.567 0.433
E70.3 Albinism
0.000 0.567 0.433
E70.2 Disorders of tyrosine metabolism
0.000 0.567 0.433
E70.1 Other hyperphenylalaninaemias
0.000 0.567 0.433
E70.0 Classical phenylketonuria
0.000 0.567 0.433
E71.3 Disorders of fatty-acid metabolism
0.000 0.567 0.433
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.567 0.433
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.567 0.433
E71.0 Maple-syrup-urine disease
0.000 0.567 0.433
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.567 0.433
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.567 0.433
E72.5 Disorders of glycine metabolism
0.000 0.567 0.433
E72.4 Disorders of ornithine metabolism
0.000 0.567 0.433
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.567 0.433
E72.2 Disorders of urea cycle metabolism
0.000 0.567 0.433
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.567 0.433
E72.0 Disorders of amino-acid transport
0.000 0.567 0.433
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.567 0.433
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.567 0.433
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.567 0.433
E76.2 Other mucopolysaccharidoses
0.000 0.567 0.433
E76.1 Mucopolysaccharidosis, type II
0.000 0.567 0.433
E76.0 Mucopolysaccharidosis, type I
0.000 0.567 0.433
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.567 0.433
E77.8 Other disorders of glycoprotein metabolism
0.000 0.567 0.433
E77.1 Defects in glycoprotein degradation
0.000 0.567 0.433
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.567 0.433
E75.6 Lipid storage disorder, unspecified
0.000 0.572 0.428
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.572 0.428
E75.3 Sphingolipidosis, unspecified
0.000 0.572 0.428
E75.2 Other sphingolipidosis
0.000 0.572 0.428
E75.1 Other gangliosidosis
0.000 0.572 0.428
E75.0 GM2 gangliosidosis
0.000 0.572 0.428
E03.5 Myxoedema coma
0.000 0.574 0.426
E03.4 Atrophy of thyroid (acquired)
0.000 0.574 0.426
E03.3 Postinfectious hypothyroidism
0.000 0.574 0.426
E03.1 Congenital hypothyroidism without goitre
0.000 0.574 0.426
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.574 0.426
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.574 0.425
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.574 0.425
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.574 0.425
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.574 0.425
E75.5 Other lipid storage disorders
0.000 0.579 0.420
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.580 0.420
K90 Intestinal malabsorption
0.000 0.583 0.417
E88 Other metabolic disorders
0.001 0.584 0.415
E65-E68 Obesity and other hyperalimentation
0.000 0.591 0.408
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.592 0.407
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.593 0.407
E07 Other disorders of thyroid
0.000 0.596 0.404
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.600 0.400
E84.8 Cystic fibrosis with other manifestations
0.000 0.603 0.397
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.603 0.397
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.603 0.397
E06 Thyroiditis
0.000 0.603 0.397
I00-I02 Acute rheumatic fever
0.000 0.608 0.392
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.612 0.388
E45 Retarded development following protein-energy malnutrition
0.000 0.612 0.388
E43 Unspecified severe protein-energy malnutrition
0.000 0.612 0.388
E42 Marasmic kwashiorkor
0.000 0.612 0.388
E41 Nutritional marasmus
0.000 0.612 0.388
E40 Kwashiorkor
0.000 0.612 0.388
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.624 0.375
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.624 0.375
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.624 0.375
E89.5 Postprocedural testicular hypofunction
0.000 0.624 0.375
E89.1 Postprocedural hypoinsulinaemia
0.000 0.624 0.375
E73.8 Other lactose intolerance
0.001 0.645 0.354
E73.1 Secondary lactase deficiency
0.001 0.645 0.354
E73.0 Congenital lactase deficiency
0.001 0.645 0.354
E89.4 Postprocedural ovarian failure
0.000 0.646 0.353
E80.6 Other disorders of bilirubin metabolism
0.000 0.649 0.350
E05.8 Other thyrotoxicosis
0.000 0.650 0.350
E83.3 Disorders of phosphorus metabolism
0.314 0.651 0.035
E84.9 Cystic fibrosis, unspecified
0.001 0.653 0.347
E50-E64 Other nutritional deficiencies
0.000 0.653 0.347
E83.9 Disorder of mineral metabolism, unspecified
0.263 0.658 0.078
E83.8 Other disorders of mineral metabolism
0.263 0.658 0.078
E83.2 Disorders of zinc metabolism
0.263 0.658 0.078
E83.0 Disorders of copper metabolism
0.263 0.658 0.078
E89.2 Postprocedural hypoparathyroidism
0.000 0.661 0.339
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.662 0.338
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.662 0.338
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.662 0.338
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.662 0.338
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.662 0.338
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.662 0.338
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.662 0.338
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.662 0.338
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.666 0.334
E80.5 Crigler-Najjar syndrome
0.000 0.666 0.334
E80.3 Defects of catalase and peroxydase
0.000 0.666 0.334
E80.2 Other porphyria
0.000 0.666 0.334
E80.1 Porphyria cutanea tarda
0.000 0.666 0.334
E80.0 Hereditary erythropoietic porphyria
0.000 0.666 0.334
E88.2 Lipomatosis, not elsewhere classified
0.000 0.672 0.327
E46 Unspecified protein-energy malnutrition
0.000 0.680 0.320
E78.9 Disorder of lipoprotein metabolism, unspecified
0.001 0.685 0.314
E88.8 Other specified metabolic disorders
0.000 0.700 0.300
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.700 0.300
K90.8 Other intestinal malabsorption
0.000 0.700 0.300
K90.3 Pancreatic steatorrhoea
0.000 0.701 0.299
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.701 0.299
K90.1 Tropical sprue
0.000 0.701 0.299
E88.9 Metabolic disorder, unspecified
0.001 0.702 0.298
E88.3 Tumour lysis syndrome
0.000 0.704 0.295
K90.9 Intestinal malabsorption, unspecified
0.000 0.704 0.296
E67 Other hyperalimentation
0.000 0.707 0.293
E68 Sequelae of hyperalimentation
0.000 0.707 0.293
E07.1 Dyshormogenetic goitre
0.000 0.710 0.290
E07.0 Hypersecretion of calcitonin
0.000 0.710 0.290
E65 Localised adiposity
0.000 0.712 0.287
E06.5 Other chronic thyroiditis
0.000 0.715 0.285
E06.4 Drug-induced thyroiditis
0.000 0.715 0.285
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.715 0.285
E06.1 Subacute thyroiditis
0.000 0.715 0.285
E06.0 Acute thyroiditis
0.000 0.715 0.285
E06.9 Thyroiditis, unspecified
0.000 0.716 0.284
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.718 0.282
I02 Rheumatic chorea
0.000 0.719 0.281
I01 Rheumatic fever with heart involvement
0.000 0.719 0.281
I00 Rheumatic fever without mention of heart involvement
0.000 0.719 0.281
E44.1 Mild protein-energy malnutrition
0.000 0.721 0.278
E44.0 Moderate protein-energy malnutrition
0.000 0.721 0.278
E07.8 Other specified disorders of thyroid
0.000 0.723 0.277
E03.8 Other specified hypothyroidism
0.001 0.745 0.255
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.751 0.249
E63 Other nutritional deficiencies
0.000 0.751 0.249
E56 Other vitamin deficiencies
0.000 0.751 0.249
E51 Thiamine deficiency
0.000 0.751 0.249
E50 Vitamin A deficiency
0.000 0.751 0.249
E60 Dietary zinc deficiency
0.000 0.751 0.249
E59 Dietary selenium deficiency
0.000 0.751 0.249
E58 Dietary calcium deficiency
0.000 0.751 0.249
E54 Ascorbic acid deficiency
0.000 0.751 0.249
E52 Niacin deficiency [pellagra]
0.000 0.751 0.249
E61 Deficiency of other nutrient elements
0.000 0.752 0.248
E20-E35 Disorders of other endocrine glands
0.000 0.754 0.246
E73.9 Lactose intolerance, unspecified
0.001 0.755 0.244
E88.1 Lipodystrophy, not elsewhere classified
0.001 0.759 0.241
E07.9 Disorder of thyroid, unspecified
0.000 0.759 0.241
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.001 0.775 0.224
E06.3 Autoimmune thyroiditis
0.000 0.787 0.213
E67.8 Other specified hyperalimentation
0.000 0.790 0.210
E67.3 Hypervitaminosis D
0.000 0.790 0.210
E67.2 Megavitamin-B6 syndrome
0.000 0.790 0.210
E67.1 Hypercarotenaemia
0.000 0.790 0.210
E67.0 Hypervitaminosis A
0.000 0.790 0.210
E22 Hyperfunction of pituitary gland
0.000 0.798 0.202
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.798 0.201
I01.8 Other acute rheumatic heart disease
0.000 0.798 0.201
I01.2 Acute rheumatic myocarditis
0.000 0.798 0.201
I01.1 Acute rheumatic endocarditis
0.000 0.798 0.201
I01.0 Acute rheumatic pericarditis
0.000 0.798 0.201
I02.9 Rheumatic chorea without heart involvement
0.000 0.798 0.201
I02.0 Rheumatic chorea with heart involvement
0.000 0.798 0.201
E89.0 Postprocedural hypothyroidism
0.000 0.799 0.201
E23 Hypofunction and other disorders of pituitary gland
0.000 0.800 0.200
E83.4 Disorders of magnesium metabolism
0.126 0.804 0.070
E55 Vitamin D deficiency
0.000 0.805 0.195
E61.1 Iron deficiency
0.000 0.816 0.184
E50.9 Vitamin A deficiency, unspecified
0.000 0.821 0.178
E50.8 Other manifestations of vitamin A deficiency
0.000 0.821 0.178
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.821 0.178
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.821 0.178
E50.5 Vitamin A deficiency with night blindness
0.000 0.821 0.178
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.821 0.178
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.821 0.178
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.821 0.178
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.821 0.178
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.821 0.178
E51.9 Thiamine deficiency, unspecified
0.000 0.821 0.178
E51.8 Other manifestations of thiamine deficiency
0.000 0.821 0.178
E51.2 Wernicke's encephalopathy
0.000 0.821 0.178
E51.1 Beriberi
0.000 0.821 0.178
E56.9 Vitamin deficiency, unspecified
0.000 0.821 0.178
E56.8 Deficiency of other vitamins
0.000 0.821 0.178
E56.1 Deficiency of vitamin K
0.000 0.821 0.178
E56.0 Deficiency of vitamin E
0.000 0.821 0.178
E63.9 Nutritional deficiency, unspecified
0.000 0.821 0.178
E63.8 Other specified nutritional deficiencies
0.000 0.821 0.178
E63.1 Imbalance of constituents of food intake
0.000 0.821 0.178
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.821 0.178
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.821 0.178
E64.8 Sequelae of other nutritional deficiencies
0.000 0.821 0.178
E64.3 Sequelae of rickets
0.000 0.821 0.178
E64.2 Sequelae of vitamin C deficiency
0.000 0.821 0.178
E64.1 Sequelae of vitamin A deficiency
0.000 0.821 0.178
E64.0 Sequelae of protein-energy malnutrition
0.000 0.821 0.178
E61.9 Deficiency of nutrient element, unspecified
0.000 0.822 0.178
E61.8 Deficiency of other specified nutrient elements
0.000 0.822 0.178
E61.7 Deficiency of multiple nutrient elements
0.000 0.822 0.178
E61.6 Vanadium deficiency
0.000 0.822 0.178
E61.5 Molybdenum deficiency
0.000 0.822 0.178
E61.4 Chromium deficiency
0.000 0.822 0.178
E61.3 Manganese deficiency
0.000 0.822 0.178
E61.0 Copper deficiency
0.000 0.822 0.178
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.823 0.177
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.823 0.177
E32 Diseases of thymus
0.000 0.823 0.177
E31 Polyglandular dysfunction
0.000 0.823 0.177
E30 Disorders of puberty, not elsewhere classified
0.000 0.823 0.177
E25 Adrenogenital disorders
0.000 0.823 0.177
E26 Hyperaldosteronism
0.000 0.826 0.174
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.826 0.174
E61.2 Magnesium deficiency
0.000 0.829 0.171
E23.6 Other disorders of pituitary gland
0.000 0.832 0.168
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.834 0.166
E24 Cushing's syndrome
0.000 0.836 0.164
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.837 0.163
E29 Testicular dysfunction
0.000 0.837 0.162
E23.2 Diabetes insipidus
0.000 0.838 0.162
E20 Hypoparathyroidism
0.000 0.840 0.160
I28 Other diseases of pulmonary vessels
0.001 0.840 0.159
E80.4 Gilbert's syndrome
0.000 0.843 0.157
E23.7 Disorder of pituitary gland, unspecified
0.000 0.847 0.152
E22.1 Hyperprolactinaemia
0.000 0.850 0.150
E28 Ovarian dysfunction
0.000 0.851 0.149
E83.5 Disorders of calcium metabolism
0.126 0.852 0.022
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.855 0.145
E22.8 Other hyperfunction of pituitary gland
0.000 0.855 0.145
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.856 0.143
E23.1 Drug-induced hypopituitarism
0.000 0.856 0.143
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.001 0.857 0.142
E55.0 Rickets, active
0.000 0.860 0.140
I27 Other pulmonary heart diseases
0.000 0.862 0.138
E34 Other endocrine disorders
0.000 0.868 0.132
E22.0 Acromegaly and pituitary gigantism
0.000 0.868 0.132
E25.9 Adrenogenital disorder, unspecified
0.000 0.873 0.127
E25.8 Other adrenogenital disorders
0.000 0.873 0.127
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.873 0.127
E30.9 Disorder of puberty, unspecified
0.000 0.873 0.127
E30.8 Other disorders of puberty
0.000 0.873 0.127
E30.1 Precocious puberty
0.000 0.873 0.127
E30.0 Delayed puberty
0.000 0.873 0.127
E31.9 Polyglandular dysfunction, unspecified
0.000 0.873 0.127
E31.8 Other polyglandular dysfunction
0.000 0.873 0.127
E31.1 Polyglandular hyperfunction
0.000 0.873 0.127
E31.0 Autoimmune polyglandular failure
0.000 0.873 0.127
E32.9 Disease of thymus, unspecified
0.000 0.873 0.127
E32.8 Other diseases of thymus
0.000 0.873 0.127
E32.1 Abscess of thymus
0.000 0.873 0.127
E32.0 Persistent hyperplasia of thymus
0.000 0.873 0.127
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.873 0.127
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.873 0.127
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.873 0.127
E26.9 Hyperaldosteronism, unspecified
0.000 0.875 0.125
E26.8 Other hyperaldosteronism
0.000 0.875 0.125
E26.1 Secondary hyperaldosteronism
0.000 0.875 0.125
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.875 0.125
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.875 0.125
E21.3 Hyperparathyroidism, unspecified
0.000 0.876 0.124
E26.0 Primary hyperaldosteronism
0.000 0.878 0.122
I27.9 Pulmonary heart disease, unspecified
0.000 0.878 0.122
I05-I09 Chronic rheumatic heart diseases
0.000 0.879 0.121
E24.8 Other Cushing's syndrome
0.000 0.882 0.118
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.882 0.118
E24.3 Ectopic ACTH syndrome
0.000 0.882 0.118
E24.2 Drug-induced Cushing's syndrome
0.000 0.882 0.118
E24.1 Nelson's syndrome
0.000 0.882 0.118
E24.0 Pituitary-dependent Cushing's disease
0.000 0.882 0.118
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.883 0.117
E21.4 Other specified disorders of parathyroid gland
0.000 0.883 0.117
E21.2 Other hyperparathyroidism
0.000 0.883 0.117
E29.9 Testicular dysfunction, unspecified
0.000 0.883 0.117

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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