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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3130498
log Bayes Factor = 56.8832
Chromosome 6   position 31,117,619  (GRCh37) Explore rs3130498 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.001 0.999
E83.1 Disorders of iron metabolism
0.999 0.001 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.005 0.995
E05.9 Thyrotoxicosis, unspecified
0.000 0.006 0.994
G35 Multiple sclerosis
0.989 0.011 0.000
E78.0 Pure hypercholesterolaemia
0.000 0.013 0.987
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.014 0.986
E70-E90 Metabolic disorders
0.000 0.019 0.981
L40 Psoriasis
0.000 0.056 0.944
E14 Unspecified diabetes mellitus
0.000 0.059 0.941
E11.0 With coma
0.000 0.116 0.883
L40.5 Arthropathic psoriasis
0.000 0.124 0.876
E78.8 Other disorders of lipoprotein metabolism
0.000 0.125 0.875
E07 Other disorders of thyroid
0.000 0.129 0.871
E14.3 With ophthalmic complications
0.000 0.150 0.850
E10.3 With ophthalmic complications
0.000 0.160 0.840
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.161 0.839
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.171 0.829
E78.2 Mixed hyperlipidaemia
0.000 0.174 0.826
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.175 0.825
E03.8 Other specified hypothyroidism
0.000 0.191 0.809
L40.0 Psoriasis vulgaris
0.000 0.195 0.805
E07.9 Disorder of thyroid, unspecified
0.000 0.212 0.788
E14.9 Without complications
0.000 0.215 0.785
G35-G37 Demyelinating diseases of the central nervous system
0.783 0.217 0.000
E11.1 With ketoacidosis
0.000 0.226 0.774
L40.8 Other psoriasis
0.000 0.229 0.771
E79 Disorders of purine and pyrimidine metabolism
0.000 0.232 0.768
E74 Other disorders of carbohydrate metabolism
0.000 0.233 0.767
E78.4 Other hyperlipidaemia
0.000 0.234 0.766
E10.6 With other specified complications
0.000 0.244 0.756
E10.8 With unspecified complications
0.000 0.247 0.753
E78.1 Pure hyperglyceridaemia
0.000 0.251 0.749
E11.2 With renal complications
0.000 0.256 0.744
E14.5 With peripheral circulatory complications
0.000 0.257 0.743
E78.5 Hyperlipidaemia, unspecified
0.000 0.257 0.743
G37 Other demyelinating diseases of central nervous system
0.726 0.274 0.000
E10.1 With ketoacidosis
0.000 0.277 0.723
L40.1 Generalised pustular psoriasis
0.000 0.278 0.721
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.716
E05.5 Thyroid crisis or storm
0.000 0.287 0.713
E05.4 Thyrotoxicosis factitia
0.000 0.287 0.713
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.287 0.713
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.287 0.713
E40-E46 Malnutrition
0.000 0.288 0.712
E10.0 With coma
0.000 0.288 0.712
E78.6 Lipoprotein deficiency
0.000 0.291 0.709
E16 Other disorders of pancreatic internal secretion
0.000 0.293 0.707
E83 Disorders of mineral metabolism
0.677 0.293 0.030
E78.3 Hyperchylomicronaemia
0.000 0.293 0.707
E77 Disorders of glycoprotein metabolism
0.000 0.296 0.703
E76 Disorders of glycosaminoglycan metabolism
0.000 0.296 0.703
E72 Other disorders of amino-acid metabolism
0.000 0.296 0.703
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.296 0.703
E70 Disorders of aromatic amino-acid metabolism
0.000 0.296 0.703
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.296 0.703
E14.4 With neurological complications
0.000 0.297 0.703
E13 Other specified diabetes mellitus
0.000 0.297 0.702
K90 Intestinal malabsorption
0.000 0.300 0.700
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.308 0.692
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.312 0.688
E14.6 With other specified complications
0.000 0.320 0.680
E14.1 With ketoacidosis
0.000 0.321 0.679
E84 Cystic fibrosis
0.000 0.322 0.678
L40.2 Acrodermatitis continua
0.000 0.323 0.677
E14.7 With multiple complications
0.000 0.325 0.675
E14.0 With coma
0.000 0.325 0.675
L40.4 Guttate psoriasis
0.000 0.329 0.671
G37.9 Demyelinating disease of central nervous system, unspecified
0.669 0.331 0.000
E14.2 Withrenal complications
0.000 0.345 0.655
E80.6 Other disorders of bilirubin metabolism
0.000 0.350 0.650
E80.4 Gilbert's syndrome
0.000 0.351 0.649
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.353 0.647
E14.8 With unspecified complications
0.000 0.364 0.636
E03.1 Congenital hypothyroidism without goitre
0.000 0.365 0.635
E80.2 Other porphyria
0.000 0.369 0.630
E11.8 With unspecified complications
0.000 0.370 0.630
E07.1 Dyshormogenetic goitre
0.000 0.375 0.625
E07.0 Hypersecretion of calcitonin
0.000 0.375 0.625
E05.8 Other thyrotoxicosis
0.000 0.376 0.624
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.377 0.623
M06.9 Rheumatoid arthritis, unspecified
0.000 0.378 0.622
E10.2 With renal complications
0.000 0.379 0.621
G36 Other acute disseminated demyelination
0.617 0.383 0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.384 0.616
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.386 0.614
E16.2 Hypoglycaemia, unspecified
0.000 0.398 0.602
E07.8 Other specified disorders of thyroid
0.000 0.401 0.599
E10.5 With peripheral circulatory complications
0.000 0.401 0.599
E15 Nondiabetic hypoglycaemic coma
0.000 0.405 0.595
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.408 0.591
E80.5 Crigler-Najjar syndrome
0.000 0.408 0.591
E80.3 Defects of catalase and peroxydase
0.000 0.408 0.591
E80.0 Hereditary erythropoietic porphyria
0.000 0.408 0.591
E80.1 Porphyria cutanea tarda
0.000 0.413 0.587
G37.8 Other specified demyelinating diseases of central nervous system
0.583 0.417 0.000
E83.3 Disorders of phosphorus metabolism
0.573 0.418 0.009
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.419 0.581
E88 Other metabolic disorders
0.000 0.427 0.573
L40-L45 Papulosquamous disorders
0.000 0.435 0.565
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.438 0.562
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.443 0.557
L40.3 Pustulosis palmaris et plantaris
0.000 0.444 0.556
E73 Lactose intolerance
0.000 0.448 0.552
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.449 0.551
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.449 0.551
E79.1 Lesch-Nyhan syndrome
0.000 0.449 0.551
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.450 0.550
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.450 0.550
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.450 0.550
E74.2 Disorders of galactose metabolism
0.000 0.450 0.550
E74.1 Disorders of fructose metabolism
0.000 0.450 0.550
K90.9 Intestinal malabsorption, unspecified
0.000 0.453 0.547
E83.9 Disorder of mineral metabolism, unspecified
0.524 0.457 0.019
E11.5 With peripheral circulatory complications
0.000 0.457 0.543
E16.1 Other hypoglycaemia
0.000 0.465 0.535
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.472 0.528
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.475 0.525
G37.5 Concentric sclerosis [Balo]
0.520 0.479 0.000
G37.4 Subacute necrotising myelitis
0.520 0.479 0.000
G37.2 Central pontine myelinolysis
0.520 0.479 0.000
G37.1 Central demyelination of corpus callosum
0.520 0.479 0.000
G37.0 Diffuse sclerosis
0.520 0.479 0.000
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.514 0.486 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.486 0.514
E13.9 Without complications
0.000 0.487 0.513
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.489 0.511
E45 Retarded development following protein-energy malnutrition
0.000 0.489 0.511
E43 Unspecified severe protein-energy malnutrition
0.000 0.489 0.511
E42 Marasmic kwashiorkor
0.000 0.489 0.511
E41 Nutritional marasmus
0.000 0.489 0.511
E40 Kwashiorkor
0.000 0.489 0.511
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.491 0.509
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.493 0.507
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.493 0.507
E16.4 Abnormal secretion of gastrin
0.000 0.493 0.507
E16.3 Increased secretion of glucagon
0.000 0.493 0.507
E83.8 Other disorders of mineral metabolism
0.485 0.493 0.022
E83.2 Disorders of zinc metabolism
0.485 0.493 0.022
E83.0 Disorders of copper metabolism
0.485 0.493 0.022
E46 Unspecified protein-energy malnutrition
0.000 0.494 0.506
E10.4 With neurological complications
0.000 0.495 0.505
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.495 0.504
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.495 0.504
E70.3 Albinism
0.000 0.495 0.504
E70.2 Disorders of tyrosine metabolism
0.000 0.495 0.504
E70.1 Other hyperphenylalaninaemias
0.000 0.495 0.504
E70.0 Classical phenylketonuria
0.000 0.495 0.504
E71.3 Disorders of fatty-acid metabolism
0.000 0.495 0.504
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.495 0.504
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.495 0.504
E71.0 Maple-syrup-urine disease
0.000 0.495 0.504
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.495 0.504
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.495 0.504
E72.5 Disorders of glycine metabolism
0.000 0.495 0.504
E72.4 Disorders of ornithine metabolism
0.000 0.495 0.504
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.495 0.504
E72.2 Disorders of urea cycle metabolism
0.000 0.495 0.504
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.495 0.504
E72.0 Disorders of amino-acid transport
0.000 0.495 0.504
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.495 0.504
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.495 0.504
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.495 0.504
E76.2 Other mucopolysaccharidoses
0.000 0.495 0.504
E76.1 Mucopolysaccharidosis, type II
0.000 0.495 0.504
E76.0 Mucopolysaccharidosis, type I
0.000 0.495 0.504
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.495 0.504
E77.8 Other disorders of glycoprotein metabolism
0.000 0.495 0.504
E77.1 Defects in glycoprotein degradation
0.000 0.495 0.504
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.495 0.504
E13.8 With unspecified complications
0.000 0.496 0.504
E13.7 With multiple complications
0.000 0.496 0.504
E13.6 With other specified complications
0.000 0.496 0.504
E13.5 With peripheral circulatory complications
0.000 0.496 0.504
E13.4 With neurological complications
0.000 0.496 0.504
E13.2 With renal complications
0.000 0.496 0.504
E13.1 With ketoacidosis
0.000 0.496 0.504
E13.0 With coma
0.000 0.496 0.504
K90.8 Other intestinal malabsorption
0.000 0.497 0.503
K90.3 Pancreatic steatorrhoea
0.000 0.498 0.502
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.498 0.502
K90.1 Tropical sprue
0.000 0.498 0.502
G36.0 Neuromyelitis optica [Devic]
0.498 0.502 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.503 0.497
E75.6 Lipid storage disorder, unspecified
0.000 0.507 0.493
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.507 0.493
E75.3 Sphingolipidosis, unspecified
0.000 0.507 0.493
E75.2 Other sphingolipidosis
0.000 0.507 0.493
E75.1 Other gangliosidosis
0.000 0.507 0.493
E75.0 GM2 gangliosidosis
0.000 0.507 0.493
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.507 0.493
E74.0 Glycogen storage disease
0.000 0.511 0.489
E84.8 Cystic fibrosis with other manifestations
0.000 0.514 0.486
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.514 0.486
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.514 0.486
E11.6 With other specified complications
0.000 0.514 0.485
E13.3 With ophthalmic complications
0.000 0.521 0.479
E75.5 Other lipid storage disorders
0.000 0.522 0.478
L43 Lichen planus
0.000 0.535 0.465
E84.9 Cystic fibrosis, unspecified
0.000 0.539 0.460
E88.2 Lipomatosis, not elsewhere classified
0.000 0.551 0.449
G36.9 Acute disseminated demyelination, unspecified
0.442 0.558 0.000
G36.8 Other specified acute disseminated demyelination
0.442 0.558 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.442 0.558 0.000
L42 Pityriasis rosea
0.000 0.558 0.442
E85 Amyloidosis
0.001 0.559 0.440
E11.4 With neurological complications
0.000 0.560 0.440
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.573 0.427
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.582 0.418
L43.9 Lichen planus, unspecified
0.000 0.583 0.417
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.587 0.412
E88.9 Metabolic disorder, unspecified
0.000 0.589 0.411
E88.8 Other specified metabolic disorders
0.000 0.589 0.411
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.591 0.409
E88.3 Tumour lysis syndrome
0.000 0.593 0.407
L44 Other papulosquamous disorders
0.000 0.595 0.405
L41 Parapsoriasis
0.000 0.595 0.405
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.595 0.405
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.602 0.398
E73.8 Other lactose intolerance
0.000 0.604 0.396
E73.1 Secondary lactase deficiency
0.000 0.604 0.396
E73.0 Congenital lactase deficiency
0.000 0.604 0.396
E06 Thyroiditis
0.000 0.615 0.385
E83.4 Disorders of magnesium metabolism
0.374 0.615 0.010
E89.4 Postprocedural ovarian failure
0.000 0.618 0.382
E83.5 Disorders of calcium metabolism
0.379 0.618 0.002
E44.1 Mild protein-energy malnutrition
0.000 0.634 0.366
E44.0 Moderate protein-energy malnutrition
0.000 0.634 0.366
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.635 0.365
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.635 0.365
E89.5 Postprocedural testicular hypofunction
0.000 0.635 0.365
E89.1 Postprocedural hypoinsulinaemia
0.000 0.635 0.365
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.638 0.362
E89.3 Postprocedural hypopituitarism
0.000 0.661 0.339
L43.3 Subacute (active) lichen planus
0.000 0.667 0.333
L43.2 Lichenoid drug reaction
0.000 0.667 0.333
L43.1 Bullous lichen planus
0.000 0.667 0.333
L43.0 Hypertrophic lichen planus
0.000 0.667 0.333
E65-E68 Obesity and other hyperalimentation
0.000 0.668 0.331
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.684 0.316
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.684 0.316
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.684 0.316
E89.2 Postprocedural hypoparathyroidism
0.000 0.689 0.311
E20-E35 Disorders of other endocrine glands
0.000 0.689 0.311
E85.8 Other amyloidosis
0.001 0.699 0.300
E85.9 Amyloidosis, unspecified
0.000 0.702 0.297
E50-E64 Other nutritional deficiencies
0.000 0.707 0.293
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.707 0.292
L41.9 Parapsoriasis, unspecified
0.000 0.709 0.290
L41.8 Other parapsoriasis
0.000 0.709 0.290
L41.5 Retiform parapsoriasis
0.000 0.709 0.290
L41.4 Large plaque parapsoriasis
0.000 0.709 0.290
L41.3 Small plaque parapsoriasis
0.000 0.709 0.290
L41.2 Lymphomatoid papulosis
0.000 0.709 0.290
L41.1 Pityriasis lichenoides chronica
0.000 0.709 0.290
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.709 0.290
L44.9 Papulosquamous disorder, unspecified
0.000 0.709 0.290
L44.8 Other specified papulosquamous disorders
0.000 0.709 0.290
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.709 0.290
L44.3 Lichen ruber moniliformis
0.000 0.709 0.290
L44.2 Lichen striatus
0.000 0.709 0.290
L44.1 Lichen nitidus
0.000 0.709 0.290
L44.0 Pityriasis rubra pilaris
0.000 0.709 0.290
M06 Other rheumatoid arthritis
0.000 0.711 0.289
C83.3 Large cell (diffuse)
0.000 0.719 0.281
E28 Ovarian dysfunction
0.000 0.723 0.277
E06.5 Other chronic thyroiditis
0.000 0.724 0.276
E06.4 Drug-induced thyroiditis
0.000 0.724 0.276
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.724 0.276
E06.0 Acute thyroiditis
0.000 0.724 0.276
L43.8 Other lichen planus
0.000 0.733 0.267
E11.3 With ophthalmic complications
0.000 0.734 0.266
E06.1 Subacute thyroiditis
0.000 0.737 0.263
E28.2 Polycystic ovarian syndrome
0.000 0.738 0.261
E85.4 Organ-limited amyloidosis
0.001 0.743 0.256
M06.3 Rheumatoid nodule
0.000 0.752 0.248
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.754 0.246
E23 Hypofunction and other disorders of pituitary gland
0.000 0.754 0.246
E73.9 Lactose intolerance, unspecified
0.001 0.755 0.244
E24 Cushing's syndrome
0.000 0.760 0.240
E67 Other hyperalimentation
0.000 0.762 0.238
E68 Sequelae of hyperalimentation
0.000 0.762 0.238
E85.3 Secondary systemic amyloidosis
0.001 0.763 0.237
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.772 0.228
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.776 0.223
E32 Diseases of thymus
0.000 0.776 0.223
E31 Polyglandular dysfunction
0.000 0.776 0.223
E30 Disorders of puberty, not elsewhere classified
0.000 0.776 0.223
E25 Adrenogenital disorders
0.000 0.776 0.223
E21.3 Hyperparathyroidism, unspecified
0.000 0.778 0.221
M06.4 Inflammatory polyarthropathy
0.000 0.789 0.210
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.790 0.210
E63 Other nutritional deficiencies
0.000 0.790 0.210
E50 Vitamin A deficiency
0.000 0.790 0.210
E60 Dietary zinc deficiency
0.000 0.790 0.210
E59 Dietary selenium deficiency
0.000 0.790 0.210
E54 Ascorbic acid deficiency
0.000 0.790 0.210
E52 Niacin deficiency [pellagra]
0.000 0.790 0.210
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.791 0.209
E26 Hyperaldosteronism
0.000 0.792 0.207
M06.2 Rheumatoid bursitis
0.000 0.793 0.207
M06.1 Adult-onset Still's disease
0.000 0.793 0.207
E56 Other vitamin deficiencies
0.000 0.794 0.206
M06.34 Rheumatoid nodule (Hand)
0.000 0.795 0.205
E58 Dietary calcium deficiency
0.000 0.797 0.203
M06.8 Other specified rheumatoid arthritis
0.000 0.797 0.203
E23.7 Disorder of pituitary gland, unspecified
0.000 0.800 0.200
E28.9 Ovarian dysfunction, unspecified
0.000 0.801 0.199
E28.8 Other ovarian dysfunction
0.000 0.801 0.199
E28.1 Androgen excess
0.000 0.801 0.199
E28.0 Oestrogen excess
0.000 0.801 0.199
E51 Thiamine deficiency
0.000 0.803 0.197
E61 Deficiency of other nutrient elements
0.000 0.804 0.196
E23.2 Diabetes insipidus
0.000 0.805 0.195
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.812 0.188
E24.2 Drug-induced Cushing's syndrome
0.000 0.814 0.186
E20 Hypoparathyroidism
0.000 0.816 0.183
E06.3 Autoimmune thyroiditis
0.000 0.818 0.182
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.819 0.181
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.822 0.178
M06.38 Rheumatoid nodule (Other)
0.000 0.822 0.178
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.822 0.178
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.822 0.178
M06.33 Rheumatoid nodule (Forearm)
0.000 0.822 0.178
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.822 0.178
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.823 0.177
E24.9 Cushing's syndrome, unspecified
0.000 0.824 0.176
E21.4 Other specified disorders of parathyroid gland
0.000 0.824 0.176
E21.2 Other hyperparathyroidism
0.000 0.824 0.176
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.824 0.176
E23.1 Drug-induced hypopituitarism
0.000 0.824 0.176
E65 Localised adiposity
0.000 0.824 0.175
E06.9 Thyroiditis, unspecified
0.001 0.825 0.174
E29 Testicular dysfunction
0.000 0.827 0.173
E24.8 Other Cushing's syndrome
0.000 0.827 0.172
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.827 0.172
E24.3 Ectopic ACTH syndrome
0.000 0.827 0.172
E24.1 Nelson's syndrome
0.000 0.827 0.172
E24.0 Pituitary-dependent Cushing's disease
0.000 0.827 0.172
E67.8 Other specified hyperalimentation
0.000 0.829 0.171
E67.3 Hypervitaminosis D
0.000 0.829 0.171
E67.2 Megavitamin-B6 syndrome
0.000 0.829 0.171
E67.1 Hypercarotenaemia
0.000 0.829 0.171
E67.0 Hypervitaminosis A
0.000 0.829 0.171
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.831 0.169
E23.6 Other disorders of pituitary gland
0.000 0.836 0.164
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.838 0.161
E23.0 Hypopituitarism
0.000 0.839 0.161
E25.9 Adrenogenital disorder, unspecified
0.000 0.840 0.160
E25.8 Other adrenogenital disorders
0.000 0.840 0.160
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.840 0.160
E30.9 Disorder of puberty, unspecified
0.000 0.840 0.160
E30.8 Other disorders of puberty
0.000 0.840 0.160
E30.1 Precocious puberty
0.000 0.840 0.160
E30.0 Delayed puberty
0.000 0.840 0.160
E31.9 Polyglandular dysfunction, unspecified
0.000 0.840 0.160
E31.8 Other polyglandular dysfunction
0.000 0.840 0.160
E31.1 Polyglandular hyperfunction
0.000 0.840 0.160
E31.0 Autoimmune polyglandular failure
0.000 0.840 0.160
E32.9 Disease of thymus, unspecified
0.000 0.840 0.160
E32.8 Other diseases of thymus
0.000 0.840 0.160
E32.1 Abscess of thymus
0.000 0.840 0.160
E32.0 Persistent hyperplasia of thymus
0.000 0.840 0.160
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.840 0.160
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.840 0.160
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.840 0.160
E28.3 Primary ovarian failure
0.000 0.845 0.154
E55 Vitamin D deficiency
0.000 0.846 0.154
E22 Hyperfunction of pituitary gland
0.000 0.846 0.154
M06.0 Seronegative rheumatoid arthritis
0.000 0.848 0.152
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.849 0.151
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.849 0.151
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.849 0.151
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.849 0.151
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.849 0.151
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.849 0.151
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.849 0.151
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.849 0.151
E50.9 Vitamin A deficiency, unspecified
0.000 0.849 0.151
E50.8 Other manifestations of vitamin A deficiency
0.000 0.849 0.151
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.849 0.151
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.849 0.151
E50.5 Vitamin A deficiency with night blindness
0.000 0.849 0.151
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.849 0.151
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.849 0.151
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.849 0.151
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.849 0.151
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.849 0.151
E63.9 Nutritional deficiency, unspecified
0.000 0.849 0.151
E63.8 Other specified nutritional deficiencies
0.000 0.849 0.151
E63.1 Imbalance of constituents of food intake
0.000 0.849 0.151
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.849 0.151
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.849 0.151
E64.8 Sequelae of other nutritional deficiencies
0.000 0.849 0.151
E64.3 Sequelae of rickets
0.000 0.849 0.151
E64.2 Sequelae of vitamin C deficiency
0.000 0.849 0.151
E64.1 Sequelae of vitamin A deficiency
0.000 0.849 0.151
E64.0 Sequelae of protein-energy malnutrition
0.000 0.849 0.151
E26.9 Hyperaldosteronism, unspecified
0.000 0.851 0.149
E26.8 Other hyperaldosteronism
0.000 0.851 0.149
E26.1 Secondary hyperaldosteronism
0.000 0.851 0.149
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.851 0.149
M06.18 Adult-onset Still's disease (Other)
0.000 0.851 0.149
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.851 0.149
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.851 0.149
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.851 0.149
M06.14 Adult-onset Still's disease (Hand)
0.000 0.851 0.149
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.851 0.149
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.851 0.149
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.851 0.149
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.851 0.149
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.851 0.149
M06.28 Rheumatoid bursitis (Other)
0.000 0.851 0.149
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.851 0.149
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.851 0.149
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.851 0.149
M06.24 Rheumatoid bursitis (Hand)
0.000 0.851 0.149
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.851 0.149
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.851 0.149
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.851 0.149
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.851 0.149
E56.9 Vitamin deficiency, unspecified
0.000 0.852 0.148
E56.8 Deficiency of other vitamins
0.000 0.852 0.148
E56.0 Deficiency of vitamin E
0.000 0.852 0.148
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.854 0.146
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.854 0.146
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.854 0.146
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.854 0.146
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.854 0.146
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.854 0.146
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.854 0.146
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.854 0.146
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.854 0.146
E56.1 Deficiency of vitamin K
0.000 0.856 0.143
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.858 0.142
E51.9 Thiamine deficiency, unspecified
0.000 0.859 0.141
E51.8 Other manifestations of thiamine deficiency
0.000 0.859 0.141
E51.1 Beriberi
0.000 0.859 0.141
E61.9 Deficiency of nutrient element, unspecified
0.000 0.859 0.141
E61.8 Deficiency of other specified nutrient elements
0.000 0.859 0.141
E61.7 Deficiency of multiple nutrient elements
0.000 0.859 0.141
E61.6 Vanadium deficiency
0.000 0.859 0.141
E61.5 Molybdenum deficiency
0.000 0.859 0.141
E61.4 Chromium deficiency
0.000 0.859 0.141
E61.3 Manganese deficiency
0.000 0.859 0.141
E61.0 Copper deficiency
0.000 0.859 0.141
E89.0 Postprocedural hypothyroidism
0.000 0.862 0.138
E61.1 Iron deficiency
0.000 0.864 0.135
E26.0 Primary hyperaldosteronism
0.000 0.867 0.133
E61.2 Magnesium deficiency
0.000 0.867 0.133
E20.8 Other hypoparathyroidism
0.000 0.868 0.132
E20.1 Pseudohypoparathyroidism
0.000 0.868 0.132
E20.0 Idiopathic hypoparathyroidism
0.000 0.868 0.132
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.870 0.130
E51.2 Wernicke's encephalopathy
0.000 0.872 0.128
E29.9 Testicular dysfunction, unspecified
0.000 0.876 0.124
E29.8 Other testicular dysfunction
0.000 0.876 0.124
E29.0 Testicular hyperfunction
0.000 0.876 0.124
E55.0 Rickets, active
0.000 0.889 0.111
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.889 0.111
E22.8 Other hyperfunction of pituitary gland
0.000 0.889 0.111
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.890 0.110
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.891 0.109
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.891 0.109

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

This website was created, designed, and edited by ORCID iD iconPatrick K. Albers

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