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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3130617
log Bayes Factor = 167.756
Chromosome 6   position 31,627,523  (GRCh37) Explore rs3130617 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
L40 Psoriasis
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
L40-L45 Papulosquamous disorders
0.000 0.000 1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
E10.4 With neurological complications
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
H36 Retinal disorders in diseases classified elsewhere
0.000 0.000 1.000
D64.9 Anaemia, unspecified
0.000 0.000 1.000
M45 Ankylosing spondylitis
0.000 0.001 0.999
I20.9 Angina pectoris, unspecified
0.000 0.001 0.999
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.001 0.999
H30-H36 Disorders of choroid and retina
0.000 0.001 0.999
M07 Psoriatic and enteropathic arthropathies
0.000 0.001 0.999
L43 Lichen planus
0.000 0.001 0.999
E14.9 Without complications
0.000 0.001 0.999
E11.3 With ophthalmic complications
0.000 0.001 0.999
M07.3 Other psoriatic arthropathies
0.000 0.001 0.999
Chapter VII Diseases of the eye and adnexa
0.000 0.001 0.999
I22 Subsequent myocardial infarction
0.000 0.002 0.998
E83.1 Disorders of iron metabolism
0.998 0.002 0.000
E14.3 With ophthalmic complications
0.000 0.002 0.998
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.002 0.998
M45-M49 Spondylopathies
0.000 0.002 0.998
L43.9 Lichen planus, unspecified
0.000 0.002 0.998
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.004 0.996
Chapter IX Diseases of the circulatory system
0.000 0.005 0.995
G35-G37 Demyelinating diseases of the central nervous system
0.992 0.006 0.002
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.006 0.994
E10.5 With peripheral circulatory complications
0.000 0.007 0.993
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.007 0.993
E78.0 Pure hypercholesterolaemia
0.000 0.008 0.992
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.010 0.990
G37 Other demyelinating diseases of central nervous system
0.990 0.010 0.001
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.010 0.990
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.010 0.990
I21 Acute myocardial infarction
0.000 0.011 0.989
E70-E90 Metabolic disorders
0.000 0.011 0.989
D64 Other anaemias
0.000 0.012 0.988
G37.9 Demyelinating disease of central nervous system, unspecified
0.988 0.012 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.012 0.988
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.013 0.987
D60-D64 Aplastic and other anaemias
0.000 0.017 0.983
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.018 0.982
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.018 0.982
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.020 0.980
M35.3 Polymyalgia rheumatica
0.000 0.020 0.980
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.021 0.979
H43-H45 Disorders of vitreous body and globe
0.000 0.021 0.979
E16 Other disorders of pancreatic internal secretion
0.000 0.021 0.979
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.022 0.978
E05.9 Thyrotoxicosis, unspecified
0.000 0.023 0.977
M06.0 Seronegative rheumatoid arthritis
0.000 0.023 0.977
M35 Other systemic involvement of connective tissue
0.000 0.023 0.977
E06 Thyroiditis
0.000 0.025 0.975
M20-M25 Other joint disorders
0.000 0.026 0.974
H43 Disorders of vitreous body
0.000 0.027 0.973
I20.0 Unstable angina
0.000 0.027 0.973
E16.2 Hypoglycaemia, unspecified
0.000 0.028 0.972
I21.9 Acute myocardial infarction, unspecified
0.000 0.031 0.969
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.033 0.967
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.035 0.965
I25.5 Ischaemic cardiomyopathy
0.000 0.036 0.964
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.037 0.963
I10-I15 Hypertensive diseases
0.000 0.039 0.961
E10.2 With renal complications
0.000 0.039 0.961
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.044 0.956
E06.3 Autoimmune thyroiditis
0.000 0.046 0.954
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.050 0.950
E11.5 With peripheral circulatory complications
0.000 0.050 0.950
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.050 0.950
H34 Retinal vascular occlusions
0.000 0.052 0.948
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.056 0.944
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.062 0.938
L40.0 Psoriasis vulgaris
0.000 0.066 0.934
M06.3 Rheumatoid nodule
0.000 0.068 0.932
E78.2 Mixed hyperlipidaemia
0.000 0.069 0.931
I24 Other acute ischaemic heart diseases
0.000 0.073 0.927
I12 Hypertensive renal disease
0.000 0.077 0.923
E10.0 With coma
0.000 0.081 0.919
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.919 0.081 0.000
H43.8 Other disorders of vitreous body
0.000 0.081 0.919
E10.8 With unspecified complications
0.000 0.086 0.914
E10.6 With other specified complications
0.000 0.089 0.911
I12.9 Hypertensive renal disease without renal failure
0.000 0.098 0.902
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.106 0.894
H34.8 Other retinal vascular occlusions
0.000 0.106 0.894
E11.1 With ketoacidosis
0.000 0.127 0.873
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.129 0.871
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.136 0.864
L43.8 Other lichen planus
0.000 0.138 0.862
M34 Systemic sclerosis
0.000 0.139 0.861
L40.8 Other psoriasis
0.000 0.144 0.856
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.145 0.855
E78.8 Other disorders of lipoprotein metabolism
0.000 0.145 0.855
H43.3 Other vitreous opacities
0.000 0.145 0.855
H30 Chorioretinal inflammation
0.000 0.146 0.854
I15 Secondary hypertension
0.000 0.149 0.851
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.156 0.844
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.158 0.842
M35.7 Hypermobility syndrome
0.000 0.159 0.841
H43.1 Vitreous haemorrhage
0.000 0.166 0.834
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.167 0.833
H43.2 Crystalline deposits in vitreous body
0.000 0.177 0.823
H20 Iridocyclitis
0.000 0.181 0.819
G37.8 Other specified demyelinating diseases of central nervous system
0.815 0.184 0.000
M06.34 Rheumatoid nodule (Hand)
0.000 0.188 0.812
H43.9 Disorder of vitreous body, unspecified
0.000 0.191 0.809
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.195 0.805
M34.1 CR(E)ST syndrome
0.000 0.196 0.804
E14.6 With other specified complications
0.000 0.200 0.800
I05-I09 Chronic rheumatic heart diseases
0.000 0.200 0.800
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.201 0.799
E11.2 With renal complications
0.000 0.204 0.796
E78.4 Other hyperlipidaemia
0.000 0.204 0.796
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.205 0.795
E74 Other disorders of carbohydrate metabolism
0.000 0.207 0.793
H35 Other retinal disorders
0.000 0.210 0.790
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.211 0.789
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.215 0.785
E11.4 With neurological complications
0.000 0.215 0.785
E14.5 With peripheral circulatory complications
0.000 0.217 0.783
M14 Arthropathies in other diseases classified elsewhere
0.000 0.217 0.783
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.218 0.782
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.220 0.780
E11.0 With coma
0.000 0.222 0.778
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.224 0.776
M35.1 Other overlap syndromes
0.000 0.231 0.769
H35.8 Other specified retinal disorders
0.000 0.234 0.766
I25.3 Aneurysm of heart
0.000 0.241 0.759
H30.9 Chorioretinal inflammation, unspecified
0.000 0.249 0.751
M49 Spondylopathies in diseases classified elsewhere
0.000 0.250 0.750
I15.1 Hypertension secondary to other renal disorders
0.000 0.252 0.748
E14.1 With ketoacidosis
0.000 0.252 0.748
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.254 0.746
M25 Other joint disorders, not elsewhere classified
0.000 0.255 0.745
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.255 0.745
M25.4 Effusion of joint
0.000 0.264 0.736
H20.9 Iridocyclitis, unspecified
0.000 0.264 0.736
I10 Essential (primary) hypertension
0.000 0.268 0.732
M30 Polyarteritis nodosa and related conditions
0.000 0.270 0.730
M25.46 Effusion of joint (Lower leg)
0.000 0.271 0.729
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.272 0.728
M12 Other specific arthropathies
0.000 0.273 0.727
H15 Disorders of sclera
0.000 0.274 0.726
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.275 0.725
E06.5 Other chronic thyroiditis
0.000 0.277 0.723
I00-I02 Acute rheumatic fever
0.000 0.278 0.722
D61 Other aplastic anaemias
0.000 0.278 0.722
H34.2 Other retinal artery occlusions
0.000 0.280 0.720
E40-E46 Malnutrition
0.000 0.281 0.719
M06.4 Inflammatory polyarthropathy
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
L44 Other papulosquamous disorders
0.000 0.283 0.717
L41 Parapsoriasis
0.000 0.283 0.717
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.2 Rheumatoid vasculitis
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.283 0.717
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.283 0.717
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.283 0.717
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.283 0.717
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.283 0.717
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.283 0.717
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.283 0.717
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.283 0.717
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.283 0.717
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.283 0.716
M07.6 Other enteropathic arthropathies
0.000 0.284 0.716
M07.5 Arthropathy in ulcerative colitis
0.000 0.284 0.716
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.284 0.716
M07.2 Psoriatic spondylitis
0.000 0.284 0.716
M07.1 Arthritis mutilans
0.000 0.284 0.716
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.284 0.716
L43.3 Subacute (active) lichen planus
0.000 0.284 0.716
L43.2 Lichenoid drug reaction
0.000 0.284 0.716
L43.1 Bullous lichen planus
0.000 0.284 0.716
L43.0 Hypertrophic lichen planus
0.000 0.284 0.716
E06.9 Thyroiditis, unspecified
0.000 0.284 0.716
M07.38 Other psoriatic arthropathies (Other)
0.000 0.284 0.716
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.284 0.716
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.284 0.716
E05.5 Thyroid crisis or storm
0.000 0.284 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.284 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.284 0.716
E89.3 Postprocedural hypopituitarism
0.000 0.286 0.714
E13 Other specified diabetes mellitus
0.000 0.286 0.714
E11.6 With other specified complications
0.000 0.287 0.713
E78.6 Lipoprotein deficiency
0.000 0.287 0.713
G36 Other acute disseminated demyelination
0.711 0.287 0.002
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.290 0.710
E78.3 Hyperchylomicronaemia
0.000 0.290 0.710
G37.5 Concentric sclerosis [Balo]
0.710 0.290 0.001
G37.4 Subacute necrotising myelitis
0.710 0.290 0.001
G37.2 Central pontine myelinolysis
0.710 0.290 0.001
G37.1 Central demyelination of corpus callosum
0.710 0.290 0.001
G37.0 Diffuse sclerosis
0.710 0.290 0.001
H34.9 Retinal vascular occlusion, unspecified
0.000 0.291 0.709
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.291 0.709
E77 Disorders of glycoprotein metabolism
0.000 0.291 0.709
E76 Disorders of glycosaminoglycan metabolism
0.000 0.291 0.709
E72 Other disorders of amino-acid metabolism
0.000 0.291 0.709
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.291 0.709
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.291 0.709
E79 Disorders of purine and pyrimidine metabolism
0.000 0.291 0.709
D64.4 Congenital dyserythropoietic anaemia
0.000 0.292 0.708
D64.3 Other sideroblastic anaemias
0.000 0.292 0.708
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.292 0.708
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.292 0.708
D64.0 Hereditary sideroblastic anaemia
0.000 0.292 0.708
E15 Nondiabetic hypoglycaemic coma
0.000 0.292 0.708
M35.2 Behcet's disease
0.000 0.293 0.706
E70 Disorders of aromatic amino-acid metabolism
0.000 0.294 0.706
M24 Other specific joint derangements
0.000 0.294 0.706
H34.1 Central retinal artery occlusion
0.000 0.294 0.706
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.295 0.705
L10-L14 Bullous disorders
0.000 0.297 0.703
H35.4 Peripheral retinal degeneration
0.000 0.298 0.702
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.298 0.702
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.298 0.702
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.298 0.702
E16.4 Abnormal secretion of gastrin
0.000 0.298 0.702
E16.3 Increased secretion of glucagon
0.000 0.298 0.702
D62 Acute posthaemorrhagic anaemia
0.000 0.299 0.701
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.300 0.700
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.300 0.700
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.300 0.700
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.300 0.700
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.300 0.700
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.300 0.700
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.300 0.700
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.300 0.700
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.300 0.700
M35.5 Multifocal fibrosclerosis
0.000 0.300 0.700
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.300 0.700
M65-M68 Disorders of synovium and tendon
0.000 0.301 0.699
E06.4 Drug-induced thyroiditis
0.000 0.301 0.699
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.301 0.699
E06.1 Subacute thyroiditis
0.000 0.301 0.699
E06.0 Acute thyroiditis
0.000 0.301 0.699
M33 Dermatopolymyositis
0.000 0.301 0.699
I23 Certain current complications following acute myocardial infarction
0.000 0.302 0.698
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.302 0.698
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.302 0.698
I08 Multiple valve diseases
0.000 0.305 0.695
M80-M85 Disorders of bone density and structure
0.000 0.307 0.693
H20.0 Acute and subacute iridocyclitis
0.000 0.307 0.693
Chapter VI Diseases of the nervous system
0.089 0.310 0.602
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.000 0.312 0.688
M14.6 Neuropathic arthropathy
0.000 0.316 0.684
H21 Other disorders of iris and ciliary body
0.000 0.318 0.682
H34.0 Transient retinal artery occlusion
0.000 0.320 0.680
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.322 0.678
H43.0 Vitreous prolapse
0.000 0.326 0.674
E11.8 With unspecified complications
0.000 0.327 0.673
E14.2 Withrenal complications
0.000 0.327 0.672
L42 Pityriasis rosea
0.000 0.329 0.671
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.668 0.331 0.000
E14.4 With neurological complications
0.000 0.331 0.668
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.332 0.668
M06.38 Rheumatoid nodule (Other)
0.000 0.332 0.668
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.332 0.668
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.332 0.668
M06.33 Rheumatoid nodule (Forearm)
0.000 0.332 0.668
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.332 0.668
E89.0 Postprocedural hypothyroidism
0.000 0.334 0.666
I15.9 Seconday hypertension, unspecified
0.000 0.336 0.664
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.337 0.663
M65 Synovitis and tenosynovitis
0.000 0.340 0.660
E78.1 Pure hyperglyceridaemia
0.000 0.340 0.660
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.342 0.658
M25.6 Stiffness of joint, not elsewhere classified
0.000 0.343 0.657
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.000 0.344 0.656
H20.8 Other iridocyclitis
0.000 0.345 0.655
I83 Varicose veins of lower extremities
0.654 0.346 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.347 0.653
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.349 0.651
H55-H59 Other disorders of eye and adnexa
0.000 0.350 0.650
I09 Other rheumatic heart diseases
0.000 0.351 0.649
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.351 0.649
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.352 0.648
M80 Osteoporosis with pathological fracture
0.000 0.352 0.648
K90 Intestinal malabsorption
0.000 0.353 0.647
I13 Hypertensive heart and renal disease
0.000 0.354 0.646
M82 Osteoporosis in diseases classified elsewhere
0.000 0.355 0.645
E89.4 Postprocedural ovarian failure
0.000 0.355 0.645
I22.8 Subsequent myocardial infarction of other sites
0.000 0.355 0.644
E07 Other disorders of thyroid
0.000 0.357 0.643
D50-D53 Nutritional anaemias
0.000 0.357 0.643
D63 Anaemia in chronic diseases classified elsewhere
0.000 0.358 0.642
E84 Cystic fibrosis
0.000 0.359 0.641
D55-D59 Haemolytic anaemias
0.000 0.360 0.640
E89.2 Postprocedural hypoparathyroidism
0.000 0.364 0.636
H40-H42 Glaucoma
0.000 0.366 0.634
M80.9 Unspecified osteoporosis with pathological fracture
0.000 0.371 0.629
E86 Volume depletion
0.000 0.373 0.627
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.373 0.627
E88 Other metabolic disorders
0.000 0.374 0.626
I25.4 Coronary artery aneurysm
0.000 0.376 0.623
E50-E64 Other nutritional deficiencies
0.000 0.376 0.624
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.377 0.623
E73 Lactose intolerance
0.000 0.378 0.622
M65.4 Radial styloid tenosynovitis [de Quervain]
0.000 0.378 0.622
H35.2 Other proliferative retinopathy
0.000 0.382 0.618
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.383 0.617
M25.40 Effusion of joint (Multiple sites)
0.000 0.383 0.617
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.000 0.383 0.617
M24.0 Loose body in joint
0.000 0.384 0.616
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.387 0.613
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.387 0.613
E89.5 Postprocedural testicular hypofunction
0.000 0.387 0.613
E89.1 Postprocedural hypoinsulinaemia
0.000 0.387 0.613
E03.8 Other specified hypothyroidism
0.000 0.387 0.613
H30.8 Other chorioretinal inflammations
0.000 0.387 0.613
H30.2 Posterior cyclitis
0.000 0.387 0.613
H30.1 Disseminated chorioretinal inflammation
0.000 0.387 0.613
H30.0 Focal chorioretinal inflammation
0.000 0.387 0.613
E16.1 Other hypoglycaemia
0.000 0.388 0.612
M24.6 Ankylosis of joint
0.000 0.388 0.612
M82.1 Osteoporosis in endocrine disorders
0.000 0.388 0.612
M00-M03 Infectious arthropathies
0.000 0.389 0.610
I15.8 Other secondary hypertension
0.000 0.390 0.610
I15.2 Hypertension secondary to endocrine disorders
0.000 0.390 0.610
I15.0 Renovascular hypertension
0.000 0.390 0.610
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.392 0.608
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.395 0.605
M91-M94 Chondropathies
0.000 0.395 0.605
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.397 0.603
D61.1 Drug-induced aplastic anaemia
0.000 0.398 0.602
H15.1 Episcleritis
0.000 0.401 0.599
I83.0 Varicose veins of lower extremities with ulcer
0.598 0.402 0.000
M34.9 Systemic sclerosis, unspecified
0.000 0.403 0.597
M34.0 Progressive systemic sclerosis
0.000 0.404 0.595
M32 Systemic lupus erythematosus
0.000 0.405 0.595
M35.8 Other specified systemic involvement of connective tissue
0.000 0.405 0.595
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.000 0.407 0.593
G70-G73 Diseases of myoneural junction and muscle
0.019 0.408 0.573
M24.7 Protrusio acetabuli
0.000 0.410 0.590
G50-G59 Nerve, nerve root and plexus disorders
0.007 0.411 0.582
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.412 0.588
E03.1 Congenital hypothyroidism without goitre
0.000 0.412 0.588
H20.2 Lens-induced iridocyclitis
0.000 0.413 0.587
I08.0 Disorders of both mitral and aortic valves
0.000 0.414 0.586
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.415 0.585
H20.1 Chronic iridocyclitis
0.000 0.416 0.584
I24.1 Dressler's syndrome
0.000 0.416 0.583
M80.98 Unspecified osteoporosis with pathological fracture (Other)
0.000 0.418 0.582
I12.0 Hypertensive renal disease with renal failure
0.000 0.418 0.582
M25.43 Effusion of joint (Forearm)
0.000 0.418 0.582
G59 Mononeuropathy in diseases classified elsewhere
0.003 0.418 0.579
I07 Rheumatic tricuspid valve diseases
0.000 0.419 0.581
H15.8 Other disorders of sclera
0.000 0.419 0.581
K90-K93 Other diseases of the digestive system
0.000 0.419 0.581
K70-K77 Diseases of liver
0.000 0.420 0.580
H33 Retinal detachments and breaks
0.000 0.420 0.580
I24.8 Other forms of acute ischaemic heart disease
0.000 0.421 0.579
G59.0 Diabetic mononeuropathy
0.000 0.422 0.578
G56.0 Carpal tunnel syndrome
0.000 0.422 0.578
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.422 0.578
Chapter XI Diseases of the digestive system
0.000 0.423 0.577
L40.3 Pustulosis palmaris et plantaris
0.000 0.424 0.576
G56 Mononeuropathies of upper limb
0.000 0.424 0.576
K75 Other inflammatory liver diseases
0.000 0.425 0.575
M60-M63 Disorders of muscles
0.000 0.425 0.575
H21.0 Hyphaema
0.000 0.425 0.574
M11 Other crystal arthropathies
0.000 0.426 0.574
K75.4 Autoimmune hepatitis
0.000 0.427 0.573
M49.5 Collapsed vertebra in diseases classified elsewhere
0.000 0.428 0.572
M12.3 Palindromic rheumatism
0.000 0.431 0.569
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.431 0.569
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.431 0.569
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.431 0.569
E74.2 Disorders of galactose metabolism
0.000 0.431 0.569
E74.1 Disorders of fructose metabolism
0.000 0.431 0.569
E74.0 Glycogen storage disease
0.000 0.431 0.569
M34.8 Other forms of systemic sclerosis
0.000 0.432 0.568
M82.11 Osteoporosis in endocrine disorders (Shoulder region)
0.000 0.434 0.566
H35.1 Retinopathy of prematurity
0.000 0.434 0.566
M25.47 Effusion of joint (Ankle and foot)
0.000 0.435 0.565
H35.6 Retinal haemorrhage
0.000 0.437 0.563
K74 Fibrosis and cirrhosis of liver
0.000 0.438 0.562
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)
0.000 0.439 0.561
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders
0.000 0.439 0.561
M14.4 Arthropathy in amyloidosis
0.000 0.439 0.561
M14.3 Lipoid dermatoarthritis
0.000 0.439 0.561
M14.1 Crystal arthropathy in other metabolic disorders
0.000 0.439 0.561
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders
0.000 0.439 0.561
M24.1 Other articular cartilage disorders
0.000 0.439 0.561
D51 Vitamin B12 deficiency anaemia
0.000 0.441 0.559
M65.8 Other synovitis and tenosynovitis
0.000 0.444 0.556
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.446 0.554
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.448 0.552
M30.0 Polyarteritis nodosa
0.000 0.449 0.551
E83 Disorders of mineral metabolism
0.413 0.450 0.137
K74.3 Primary biliary cirrhosis
0.000 0.451 0.549
M13 Other arthritis
0.000 0.452 0.548
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.000 0.453 0.547
H19.1 Herpesviral keratitis and keratoconjunctivitis
0.000 0.453 0.547
H33.2 Serous retinal detachment
0.000 0.454 0.546
M25.3 Other instability of joint
0.000 0.454 0.546
M24.02 Loose body in joint (Upper arm)
0.000 0.455 0.545
M35.0 Sicca syndrome [Sjogren]
0.000 0.456 0.544
L50-L54 Urticaria and erythema
0.000 0.457 0.542
I09.9 Rheumatic heart disease, unspecified
0.000 0.459 0.541
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)
0.000 0.459 0.541
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.460 0.540
D64.8 Other specified anaemias
0.000 0.460 0.540
G90-G99 Other disorders of the nervous system
0.014 0.460 0.526
H17 Corneal scars and opacities
0.000 0.461 0.539
M49.8 Spondylopathy in other diseases classified elsewhere
0.000 0.462 0.538
M49.4 Neuropathic spondylopathy
0.000 0.462 0.538
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere
0.000 0.462 0.538
M49.2 Enterobacterial spondylitis
0.000 0.462 0.538
M49.1 Brucella spondylitis
0.000 0.462 0.538
M49.0 Tuberculosis of spine
0.000 0.462 0.538
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.011 0.463 0.526
M31 Other necrotising vasculopathies
0.000 0.465 0.535
M25.2 Flail joint
0.000 0.465 0.534
M25.1 Fistula of joint
0.000 0.465 0.534
H21.2 Degeneration of iris and ciliary body
0.000 0.468 0.532
I11 Hypertensive heart disease
0.000 0.469 0.531
L56.8 Other specified acute skin changes due to ultraviolet radiation
0.000 0.470 0.530
I08.1 Disorders of both mitral and tricuspid valves
0.000 0.470 0.530
M30.1 Polyarteritis with lung involvement [Churg-Strauss]
0.000 0.471 0.529
M25.9 Joint disorder, unspecified
0.000 0.471 0.529
M25.49 Effusion of joint (Site unspecified)
0.000 0.472 0.528
M25.48 Effusion of joint (Other)
0.000 0.472 0.528
I00 Rheumatic fever without mention of heart involvement
0.000 0.473 0.527
K72 Hepatic failure, not elsewhere classified
0.000 0.475 0.525
M30.8 Other conditions related to polyarteritis nodosa
0.000 0.476 0.523
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]
0.000 0.476 0.523
M30.2 Juvenile polyarteritis
0.000 0.476 0.523
M33.1 Other dermatomyositis
0.000 0.477 0.523
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)
0.000 0.478 0.522
M25.42 Effusion of joint (Upper arm)
0.000 0.478 0.522
E80.6 Other disorders of bilirubin metabolism
0.000 0.478 0.521
M12.8 Other specific arthropathies, not elsewhere classified
0.000 0.479 0.521
M12.5 Traumatic arthropathy
0.000 0.479 0.521
M12.4 Intermittent hydrarthrosis
0.000 0.479 0.521
M12.1 Kaschin-Beck disease
0.000 0.479 0.521
M12.0 Chronic postrheumatic arthropathy [Jaccoud]
0.000 0.479 0.521
H15.9 Disorder of sclera, unspecified
0.000 0.479 0.520
L56.9 Acute skin change due to ultraviolet radiation, unspecified
0.000 0.480 0.520
H35.7 Separation of retinal layers
0.000 0.480 0.519
E80.2 Other porphyria
0.000 0.481 0.519

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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