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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3130636
log Bayes Factor = 46.9094
Chromosome 6   position 31,488,191  (GRCh37) Explore rs3130636 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.003 0.997
E05.9 Thyrotoxicosis, unspecified
0.000 0.003 0.997
E00-E07 Disorders of thyroid gland
0.000 0.005 0.995
E11 Non-insulin-dependent diabetes mellitus
0.000 0.006 0.994
E11.9 Without complications
0.000 0.008 0.992
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.009 0.991
E14.3 With ophthalmic complications
0.000 0.010 0.990
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.014 0.986
E10.4 With neurological complications
0.000 0.020 0.980
E10.1 With ketoacidosis
0.000 0.027 0.973
E03 Other hypothyroidism
0.000 0.036 0.964
E03.9 Hypothyroidism, unspecified
0.000 0.042 0.958
E14.9 Without complications
0.000 0.047 0.953
E10.2 With renal complications
0.000 0.073 0.927
E11.0 With coma
0.000 0.075 0.925
J45.9 Asthma, unspecified
0.000 0.079 0.921
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.166 0.834
E14.8 With unspecified complications
0.000 0.167 0.833
G35-G37 Demyelinating diseases of the central nervous system
0.809 0.191 0.000
E10.8 With unspecified complications
0.000 0.194 0.806
E83.1 Disorders of iron metabolism
0.806 0.194 0.000
E13 Other specified diabetes mellitus
0.000 0.201 0.799
E10.0 With coma
0.000 0.206 0.794
E07 Other disorders of thyroid
0.000 0.208 0.792
E10.5 With peripheral circulatory complications
0.000 0.218 0.782
E11.5 With peripheral circulatory complications
0.000 0.221 0.779
G37 Other demyelinating diseases of central nervous system
0.770 0.229 0.000
E14.6 With other specified complications
0.000 0.235 0.765
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.255 0.745
E14.5 With peripheral circulatory complications
0.000 0.256 0.744
E14.4 With neurological complications
0.000 0.261 0.739
E14.1 With ketoacidosis
0.000 0.263 0.737
G37.9 Demyelinating disease of central nervous system, unspecified
0.725 0.275 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.279 0.721
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.284 0.716
E14.2 Withrenal complications
0.000 0.284 0.716
E14.0 With coma
0.000 0.284 0.716
E05.5 Thyroid crisis or storm
0.000 0.285 0.715
E05.4 Thyrotoxicosis factitia
0.000 0.285 0.715
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.285 0.715
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.285 0.715
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.286 0.714
E00 Congenital iodine-deficiency syndrome
0.000 0.286 0.714
E11.7 With multiple complications
0.000 0.287 0.712
E06 Thyroiditis
0.000 0.293 0.707
E11.2 With renal complications
0.000 0.305 0.695
E10.6 With other specified complications
0.000 0.308 0.692
E03.5 Myxoedema coma
0.000 0.309 0.691
E03.4 Atrophy of thyroid (acquired)
0.000 0.309 0.691
E03.3 Postinfectious hypothyroidism
0.000 0.309 0.691
E11.1 With ketoacidosis
0.000 0.318 0.682
E11.6 With other specified complications
0.000 0.322 0.678
E03.1 Congenital hypothyroidism without goitre
0.000 0.323 0.677
E05.8 Other thyrotoxicosis
0.000 0.326 0.674
E07.9 Disorder of thyroid, unspecified
0.000 0.331 0.669
E13.9 Without complications
0.000 0.332 0.668
K90 Intestinal malabsorption
0.000 0.337 0.663
M06.9 Rheumatoid arthritis, unspecified
0.000 0.338 0.662
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.342 0.658
G37.8 Other specified demyelinating diseases of central nervous system
0.647 0.352 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.360 0.639
M45 Ankylosing spondylitis
0.000 0.363 0.637
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.363 0.637
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.379 0.621
E16.2 Hypoglycaemia, unspecified
0.000 0.382 0.618
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.387 0.613
K90.9 Intestinal malabsorption, unspecified
0.000 0.390 0.610
E65-E68 Obesity and other hyperalimentation
0.000 0.394 0.606
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.395 0.605
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.400 0.600
E15 Nondiabetic hypoglycaemic coma
0.000 0.402 0.598
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.407 0.593
G36 Other acute disseminated demyelination
0.582 0.417 0.000
E40-E46 Malnutrition
0.000 0.424 0.576
E11.8 With unspecified complications
0.000 0.426 0.573
E13.8 With unspecified complications
0.000 0.427 0.573
E13.7 With multiple complications
0.000 0.427 0.573
E13.6 With other specified complications
0.000 0.427 0.573
E13.5 With peripheral circulatory complications
0.000 0.427 0.573
E13.4 With neurological complications
0.000 0.427 0.573
E13.2 With renal complications
0.000 0.427 0.573
E13.1 With ketoacidosis
0.000 0.427 0.573
E13.0 With coma
0.000 0.427 0.573
E07.1 Dyshormogenetic goitre
0.000 0.432 0.568
E07.0 Hypersecretion of calcitonin
0.000 0.432 0.568
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.437 0.563
E16.1 Other hypoglycaemia
0.000 0.441 0.558
G37.5 Concentric sclerosis [Balo]
0.552 0.447 0.000
G37.4 Subacute necrotising myelitis
0.552 0.447 0.000
G37.2 Central pontine myelinolysis
0.552 0.447 0.000
G37.1 Central demyelination of corpus callosum
0.552 0.447 0.000
G37.0 Diffuse sclerosis
0.552 0.447 0.000
E13.3 With ophthalmic complications
0.000 0.450 0.550
E06.9 Thyroiditis, unspecified
0.000 0.452 0.548
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.457 0.543
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.460 0.540
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.532 0.468 0.000
E07.8 Other specified disorders of thyroid
0.000 0.475 0.525
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.481 0.519
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.483 0.517
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.483 0.517
E16.4 Abnormal secretion of gastrin
0.000 0.483 0.517
E16.3 Increased secretion of glucagon
0.000 0.483 0.517
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.488 0.512
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.488 0.512
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.488 0.512
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.488 0.512
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.488 0.512
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.488 0.512
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.488 0.512
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.488 0.512
E06.5 Other chronic thyroiditis
0.000 0.493 0.507
E06.4 Drug-induced thyroiditis
0.000 0.493 0.507
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.493 0.507
E06.1 Subacute thyroiditis
0.000 0.493 0.507
E06.0 Acute thyroiditis
0.000 0.493 0.507
E65 Localised adiposity
0.000 0.501 0.499
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.503 0.496
K90.8 Other intestinal malabsorption
0.000 0.514 0.486
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.516 0.484
K90.3 Pancreatic steatorrhoea
0.000 0.525 0.475
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.525 0.475
K90.1 Tropical sprue
0.000 0.525 0.475
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.531 0.469
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.543 0.457
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.543 0.457
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.543 0.457
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.543 0.457
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.543 0.457
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.543 0.457
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.543 0.457
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.551 0.448
E06.3 Autoimmune thyroiditis
0.000 0.554 0.446
E50-E64 Other nutritional deficiencies
0.000 0.556 0.444
E11.4 With neurological complications
0.000 0.565 0.435
E67 Other hyperalimentation
0.000 0.566 0.434
E68 Sequelae of hyperalimentation
0.000 0.566 0.434
G36.0 Neuromyelitis optica [Devic]
0.420 0.580 0.000
G36.9 Acute disseminated demyelination, unspecified
0.418 0.582 0.000
G36.8 Other specified acute disseminated demyelination
0.418 0.582 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.418 0.582 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.587 0.413
E45 Retarded development following protein-energy malnutrition
0.000 0.587 0.413
E43 Unspecified severe protein-energy malnutrition
0.000 0.587 0.413
E42 Marasmic kwashiorkor
0.000 0.587 0.413
E41 Nutritional marasmus
0.000 0.587 0.413
E40 Kwashiorkor
0.000 0.587 0.413
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.590 0.410
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.613 0.387
E03.8 Other specified hypothyroidism
0.001 0.642 0.357
M06 Other rheumatoid arthritis
0.000 0.661 0.339
E51 Thiamine deficiency
0.000 0.662 0.338
E58 Dietary calcium deficiency
0.000 0.674 0.326
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.682 0.318
E63 Other nutritional deficiencies
0.000 0.682 0.318
E50 Vitamin A deficiency
0.000 0.682 0.318
E60 Dietary zinc deficiency
0.000 0.682 0.318
E59 Dietary selenium deficiency
0.000 0.682 0.318
E54 Ascorbic acid deficiency
0.000 0.682 0.318
E52 Niacin deficiency [pellagra]
0.000 0.682 0.318
E56 Other vitamin deficiencies
0.000 0.685 0.315
E67.8 Other specified hyperalimentation
0.000 0.688 0.311
E67.3 Hypervitaminosis D
0.000 0.688 0.311
E67.2 Megavitamin-B6 syndrome
0.000 0.688 0.311
E67.1 Hypercarotenaemia
0.000 0.688 0.311
E67.0 Hypervitaminosis A
0.000 0.688 0.311
E20-E35 Disorders of other endocrine glands
0.000 0.700 0.300
E44.1 Mild protein-energy malnutrition
0.000 0.704 0.296
E44.0 Moderate protein-energy malnutrition
0.000 0.704 0.296
E61 Deficiency of other nutrient elements
0.000 0.710 0.290
M06.4 Inflammatory polyarthropathy
0.000 0.712 0.288
E46 Unspecified protein-energy malnutrition
0.000 0.722 0.278
E55 Vitamin D deficiency
0.000 0.729 0.271
E51.2 Wernicke's encephalopathy
0.000 0.738 0.262
E22 Hyperfunction of pituitary gland
0.000 0.738 0.262
M06.3 Rheumatoid nodule
0.000 0.739 0.261
M06.8 Other specified rheumatoid arthritis
0.000 0.757 0.243
M06.2 Rheumatoid bursitis
0.000 0.757 0.243
M06.1 Adult-onset Still's disease
0.000 0.757 0.243
E51.9 Thiamine deficiency, unspecified
0.000 0.757 0.242
E51.8 Other manifestations of thiamine deficiency
0.000 0.757 0.242
E51.1 Beriberi
0.000 0.757 0.242
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.759 0.241
E29 Testicular dysfunction
0.000 0.763 0.237
E23 Hypofunction and other disorders of pituitary gland
0.000 0.769 0.231
E50.9 Vitamin A deficiency, unspecified
0.000 0.771 0.228
E50.8 Other manifestations of vitamin A deficiency
0.000 0.771 0.228
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.771 0.228
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.771 0.228
E50.5 Vitamin A deficiency with night blindness
0.000 0.771 0.228
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.771 0.228
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.771 0.228
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.771 0.228
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.771 0.228
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.771 0.228
E63.9 Nutritional deficiency, unspecified
0.000 0.771 0.228
E63.8 Other specified nutritional deficiencies
0.000 0.771 0.228
E63.1 Imbalance of constituents of food intake
0.000 0.771 0.228
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.771 0.228
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.771 0.228
E64.8 Sequelae of other nutritional deficiencies
0.000 0.771 0.228
E64.3 Sequelae of rickets
0.000 0.771 0.228
E64.2 Sequelae of vitamin C deficiency
0.000 0.771 0.228
E64.1 Sequelae of vitamin A deficiency
0.000 0.771 0.228
E64.0 Sequelae of protein-energy malnutrition
0.000 0.771 0.228
E22.1 Hyperprolactinaemia
0.000 0.773 0.227
E56.9 Vitamin deficiency, unspecified
0.000 0.774 0.226
E56.8 Deficiency of other vitamins
0.000 0.774 0.226
E56.0 Deficiency of vitamin E
0.000 0.774 0.226
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.774 0.226
M06.34 Rheumatoid nodule (Hand)
0.000 0.774 0.225
E56.1 Deficiency of vitamin K
0.000 0.777 0.222
E25 Adrenogenital disorders
0.000 0.782 0.218
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.784 0.216
E32 Diseases of thymus
0.000 0.784 0.216
E31 Polyglandular dysfunction
0.000 0.784 0.216
E30 Disorders of puberty, not elsewhere classified
0.000 0.784 0.216
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.786 0.214
J45 Asthma
0.000 0.791 0.209
E61.9 Deficiency of nutrient element, unspecified
0.000 0.792 0.208
E61.8 Deficiency of other specified nutrient elements
0.000 0.792 0.208
E61.7 Deficiency of multiple nutrient elements
0.000 0.792 0.208
E61.6 Vanadium deficiency
0.000 0.792 0.208
E61.5 Molybdenum deficiency
0.000 0.792 0.208
E61.4 Chromium deficiency
0.000 0.792 0.208
E61.3 Manganese deficiency
0.000 0.792 0.208
E61.0 Copper deficiency
0.000 0.792 0.208
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.793 0.207
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.793 0.207
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.793 0.207
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.793 0.207
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.793 0.207
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.793 0.207
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.793 0.207
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.793 0.207
E70-E90 Metabolic disorders
0.002 0.795 0.202
E24 Cushing's syndrome
0.000 0.799 0.201
E20 Hypoparathyroidism
0.000 0.802 0.198
E11.3 With ophthalmic complications
0.000 0.803 0.197
E61.2 Magnesium deficiency
0.000 0.803 0.197
E55.0 Rickets, active
0.000 0.805 0.194
E23.2 Diabetes insipidus
0.000 0.806 0.194
E61.1 Iron deficiency
0.000 0.806 0.193
E29.1 Testicular hypofunction
0.000 0.808 0.192
E26 Hyperaldosteronism
0.000 0.809 0.191
R07.4 Chest pain, unspecified
0.000 0.810 0.190
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.811 0.189
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.812 0.188
E22.8 Other hyperfunction of pituitary gland
0.000 0.812 0.188
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.813 0.187
M06.38 Rheumatoid nodule (Other)
0.000 0.813 0.187
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.813 0.187
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.813 0.187
M06.33 Rheumatoid nodule (Forearm)
0.000 0.813 0.187
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.813 0.187
E85 Amyloidosis
0.001 0.815 0.184
E23.6 Other disorders of pituitary gland
0.000 0.815 0.185
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.820 0.180
E83 Disorders of mineral metabolism
0.146 0.820 0.034
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.823 0.177
L40.9 Psoriasis, unspecified
0.177 0.823 0.000
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.825 0.174
M06.18 Adult-onset Still's disease (Other)
0.000 0.825 0.174
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.825 0.174
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.825 0.174
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.825 0.174
M06.14 Adult-onset Still's disease (Hand)
0.000 0.825 0.174
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.825 0.174
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.825 0.174
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.825 0.174
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.825 0.174
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.825 0.174
M06.28 Rheumatoid bursitis (Other)
0.000 0.825 0.174
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.825 0.174
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.825 0.174
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.825 0.174
M06.24 Rheumatoid bursitis (Hand)
0.000 0.825 0.174
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.825 0.174
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.825 0.174
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.825 0.174
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.825 0.174
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.825 0.174
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.825 0.174
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.825 0.174
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.825 0.174
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.825 0.174
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.825 0.174
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.825 0.174
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.825 0.174
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.825 0.174
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.825 0.174
M06.0 Seronegative rheumatoid arthritis
0.000 0.826 0.174
E22.0 Acromegaly and pituitary gigantism
0.000 0.826 0.174
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.830 0.170
E29.9 Testicular dysfunction, unspecified
0.000 0.830 0.170
E29.8 Other testicular dysfunction
0.000 0.830 0.170
E29.0 Testicular hyperfunction
0.000 0.830 0.170
E78.2 Mixed hyperlipidaemia
0.000 0.831 0.169
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.831 0.168
E24.2 Drug-induced Cushing's syndrome
0.000 0.832 0.168
E34 Other endocrine disorders
0.000 0.832 0.168
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.834 0.165
E23.1 Drug-induced hypopituitarism
0.000 0.834 0.165
E85.9 Amyloidosis, unspecified
0.000 0.835 0.164
E78.5 Hyperlipidaemia, unspecified
0.000 0.836 0.164
E28 Ovarian dysfunction
0.000 0.839 0.161
E66 Obesity
0.000 0.840 0.160
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.841 0.159
E53 Deficiency of other B group vitamins
0.000 0.841 0.158
E79 Disorders of purine and pyrimidine metabolism
0.002 0.842 0.156
E23.7 Disorder of pituitary gland, unspecified
0.000 0.842 0.158
E25.9 Adrenogenital disorder, unspecified
0.000 0.843 0.157
E25.8 Other adrenogenital disorders
0.000 0.843 0.157
E30.9 Disorder of puberty, unspecified
0.000 0.845 0.155
E30.8 Other disorders of puberty
0.000 0.845 0.155
E30.1 Precocious puberty
0.000 0.845 0.155
E30.0 Delayed puberty
0.000 0.845 0.155
E31.9 Polyglandular dysfunction, unspecified
0.000 0.845 0.155
E31.8 Other polyglandular dysfunction
0.000 0.845 0.155
E31.1 Polyglandular hyperfunction
0.000 0.845 0.155
E31.0 Autoimmune polyglandular failure
0.000 0.845 0.155
E32.9 Disease of thymus, unspecified
0.000 0.845 0.155
E32.8 Other diseases of thymus
0.000 0.845 0.155
E32.1 Abscess of thymus
0.000 0.845 0.155
E32.0 Persistent hyperplasia of thymus
0.000 0.845 0.155
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.845 0.155
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.845 0.155
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.845 0.155
E89.3 Postprocedural hypopituitarism
0.000 0.848 0.152
J45.8 Mixed asthma
0.000 0.848 0.152
E78.8 Other disorders of lipoprotein metabolism
0.000 0.848 0.152
J45.1 Nonallergic asthma
0.000 0.850 0.150
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.851 0.149
E55.9 Vitamin D deficiency, unspecified
0.000 0.853 0.147
E77 Disorders of glycoprotein metabolism
0.002 0.853 0.145
E76 Disorders of glycosaminoglycan metabolism
0.002 0.853 0.145
E72 Other disorders of amino-acid metabolism
0.002 0.853 0.145
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.002 0.853 0.145
E70 Disorders of aromatic amino-acid metabolism
0.002 0.853 0.145
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.002 0.853 0.145
E78.0 Pure hypercholesterolaemia
0.000 0.853 0.147
E85.4 Organ-limited amyloidosis
0.001 0.854 0.145
E24.8 Other Cushing's syndrome
0.000 0.856 0.144
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.856 0.144
E24.3 Ectopic ACTH syndrome
0.000 0.856 0.144
E24.1 Nelson's syndrome
0.000 0.856 0.144
E20.8 Other hypoparathyroidism
0.000 0.858 0.142
E20.1 Pseudohypoparathyroidism
0.000 0.858 0.142
E20.0 Idiopathic hypoparathyroidism
0.000 0.858 0.142
E85.3 Secondary systemic amyloidosis
0.001 0.859 0.140
E78.6 Lipoprotein deficiency
0.000 0.861 0.139
E26.9 Hyperaldosteronism, unspecified
0.000 0.863 0.137
E26.8 Other hyperaldosteronism
0.000 0.863 0.137
E26.1 Secondary hyperaldosteronism
0.000 0.863 0.137
E78.1 Pure hyperglyceridaemia
0.000 0.864 0.136
E78.3 Hyperchylomicronaemia
0.000 0.864 0.135
E66.0 Obesity due to excess calories
0.000 0.865 0.135
E74 Other disorders of carbohydrate metabolism
0.002 0.866 0.132
E85.8 Other amyloidosis
0.001 0.867 0.132
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.867 0.132
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.867 0.132
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.867 0.132
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.867 0.133
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.868 0.132
E83.3 Disorders of phosphorus metabolism
0.118 0.870 0.011
E84 Cystic fibrosis
0.002 0.871 0.127
E83.9 Disorder of mineral metabolism, unspecified
0.104 0.871 0.025
E83.8 Other disorders of mineral metabolism
0.104 0.871 0.025
E83.2 Disorders of zinc metabolism
0.104 0.871 0.025
E83.0 Disorders of copper metabolism
0.104 0.871 0.025
E73 Lactose intolerance
0.002 0.871 0.127
E78.4 Other hyperlipidaemia
0.000 0.872 0.128
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.002 0.873 0.125
E34.8 Other specified endocrine disorders
0.000 0.874 0.126
E04 Other non-toxic goitre
0.000 0.874 0.126
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.875 0.125
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.875 0.125
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.875 0.125
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.875 0.125
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.875 0.125
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.875 0.125
E20.9 Hypoparathyroidism, unspecified
0.000 0.875 0.125
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.876 0.123
E24.0 Pituitary-dependent Cushing's disease
0.000 0.877 0.123
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.878 0.122
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.878 0.122
E89.5 Postprocedural testicular hypofunction
0.000 0.878 0.122
E89.1 Postprocedural hypoinsulinaemia
0.000 0.878 0.122
E34.5 Androgen resistance syndrome
0.000 0.879 0.120
E34.4 Constitutional tall stature
0.000 0.879 0.120
E34.3 Short stature, not elsewhere classified
0.000 0.879 0.120
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.879 0.120
E34.1 Other hypersecretion of intestinal hormones
0.000 0.879 0.120
E89.2 Postprocedural hypoparathyroidism
0.000 0.880 0.120
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.880 0.120
E23.0 Hypopituitarism
0.000 0.882 0.118
E28.9 Ovarian dysfunction, unspecified
0.000 0.884 0.116
E28.8 Other ovarian dysfunction
0.000 0.884 0.116
E28.1 Androgen excess
0.000 0.884 0.116
E28.0 Oestrogen excess
0.000 0.884 0.116
E28.3 Primary ovarian failure
0.000 0.885 0.115
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.885 0.114
E66.1 Drug-induced obesity
0.000 0.885 0.115
E53.1 Pyridoxine deficiency
0.000 0.886 0.114
E53.0 Riboflavin deficiency
0.000 0.886 0.114
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.887 0.112
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.887 0.112
E79.1 Lesch-Nyhan syndrome
0.001 0.887 0.112
E26.0 Primary hyperaldosteronism
0.000 0.887 0.112
E89.4 Postprocedural ovarian failure
0.000 0.888 0.111
L40 Psoriasis
0.112 0.888 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.889 0.111
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.889 0.111
E24.9 Cushing's syndrome, unspecified
0.000 0.890 0.110
E34.0 Carcinoid syndrome
0.000 0.893 0.107
E21.4 Other specified disorders of parathyroid gland
0.000 0.893 0.107
E21.2 Other hyperparathyroidism
0.000 0.893 0.107
E89.0 Postprocedural hypothyroidism
0.000 0.893 0.107
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.894 0.104
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.894 0.104
E70.3 Albinism
0.001 0.894 0.104
E70.2 Disorders of tyrosine metabolism
0.001 0.894 0.104
E70.1 Other hyperphenylalaninaemias
0.001 0.894 0.104
E70.0 Classical phenylketonuria
0.001 0.894 0.104
E71.3 Disorders of fatty-acid metabolism
0.001 0.894 0.104
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.894 0.104
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.894 0.104
E71.0 Maple-syrup-urine disease
0.001 0.894 0.104
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.894 0.104
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.894 0.104
E72.5 Disorders of glycine metabolism
0.001 0.894 0.104
E72.4 Disorders of ornithine metabolism
0.001 0.894 0.104
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.894 0.104
E72.2 Disorders of urea cycle metabolism
0.001 0.894 0.104
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.894 0.104
E72.0 Disorders of amino-acid transport
0.001 0.894 0.104
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.894 0.104
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.894 0.104
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.894 0.104
E76.2 Other mucopolysaccharidoses
0.001 0.894 0.104
E76.1 Mucopolysaccharidosis, type II
0.001 0.894 0.104
E76.0 Mucopolysaccharidosis, type I
0.001 0.894 0.104
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.894 0.104
E77.8 Other disorders of glycoprotein metabolism
0.001 0.894 0.104
E77.1 Defects in glycoprotein degradation
0.001 0.894 0.104
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.894 0.104
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.898 0.101
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.900 0.100
L40.0 Psoriasis vulgaris
0.100 0.900 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.900 0.098
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.904 0.095
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.904 0.095
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.904 0.095
E74.2 Disorders of galactose metabolism
0.001 0.904 0.095
E74.1 Disorders of fructose metabolism
0.001 0.904 0.095
E84.8 Cystic fibrosis with other manifestations
0.002 0.907 0.091
E84.1 Cystic fibrosis with intestinal manifestations
0.002 0.907 0.091
E73.8 Other lactose intolerance
0.001 0.907 0.091
E73.1 Secondary lactase deficiency
0.001 0.907 0.091
E73.0 Congenital lactase deficiency
0.001 0.907 0.091
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.908 0.092
E75.6 Lipid storage disorder, unspecified
0.002 0.908 0.090
E75.4 Neuronal ceroid lipofuscinosis
0.002 0.908 0.090
E75.3 Sphingolipidosis, unspecified
0.002 0.908 0.090
E75.1 Other gangliosidosis
0.002 0.908 0.090
E75.0 GM2 gangliosidosis
0.002 0.908 0.090
E21.3 Hyperparathyroidism, unspecified
0.000 0.909 0.091
E04.8 Other specified non-toxic goitre
0.000 0.910 0.090
E75.5 Other lipid storage disorders
0.002 0.910 0.088
L40.1 Generalised pustular psoriasis
0.088 0.912 0.000
E53.9 Vitamin B deficiency, unspecified
0.000 0.912 0.087
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.913 0.087
E84.9 Cystic fibrosis, unspecified
0.002 0.914 0.084
E84.0 Cystic fibrosis with pulmonary manifestations
0.002 0.916 0.082
E34.9 Endocrine disorder, unspecified
0.000 0.916 0.084
E80.6 Other disorders of bilirubin metabolism
0.001 0.917 0.082
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.917 0.082
E80.5 Crigler-Najjar syndrome
0.001 0.917 0.082
E80.3 Defects of catalase and peroxydase
0.001 0.917 0.082
E80.2 Other porphyria
0.001 0.917 0.082
E80.1 Porphyria cutanea tarda
0.001 0.917 0.082

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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