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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3130649
log Bayes Factor = 64.0208
Chromosome 6   position 30,803,254  (GRCh37) Explore rs3130649 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.001 0.999
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.002 0.998
L40 Psoriasis
0.984 0.016 0.000
E10.4 With neurological complications
0.000 0.023 0.977
E10.5 With peripheral circulatory complications
0.000 0.030 0.970
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.039 0.961
M35.0 Sicca syndrome [Sjogren]
0.000 0.046 0.954
E10.1 With ketoacidosis
0.000 0.052 0.948
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.061 0.939
E14 Unspecified diabetes mellitus
0.000 0.065 0.935
L40.0 Psoriasis vulgaris
0.934 0.066 0.000
L40.5 Arthropathic psoriasis
0.917 0.083 0.000
E10.2 With renal complications
0.000 0.093 0.907
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.098 0.902
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.099 0.901
E16 Other disorders of pancreatic internal secretion
0.000 0.105 0.895
E14.3 With ophthalmic complications
0.000 0.113 0.887
M35 Other systemic involvement of connective tissue
0.000 0.113 0.887
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.119 0.881
E07 Other disorders of thyroid
0.000 0.135 0.865
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.146 0.854
E10.0 With coma
0.000 0.153 0.847
E16.2 Hypoglycaemia, unspecified
0.000 0.171 0.829
E50-E64 Other nutritional deficiencies
0.000 0.175 0.825
L40.8 Other psoriasis
0.822 0.178 0.000
M35.3 Polymyalgia rheumatica
0.000 0.189 0.811
M35.1 Other overlap syndromes
0.000 0.205 0.795
E11 Non-insulin-dependent diabetes mellitus
0.000 0.205 0.795
E14.8 With unspecified complications
0.000 0.205 0.795
E10.6 With other specified complications
0.000 0.208 0.792
E07.9 Disorder of thyroid, unspecified
0.000 0.220 0.780
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.220 0.780
E11.9 Without complications
0.000 0.220 0.780
L40.3 Pustulosis palmaris et plantaris
0.755 0.245 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.249 0.751
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.253 0.747
L40.4 Guttate psoriasis
0.746 0.254 0.000
E14.6 With other specified complications
0.000 0.254 0.746
M35.2 Behcet's disease
0.000 0.257 0.743
E10.7 With multiple complications
0.000 0.263 0.737
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.284 0.716
L40.1 Generalised pustular psoriasis
0.712 0.287 0.000
E14.1 With ketoacidosis
0.000 0.288 0.711
M06 Other rheumatoid arthritis
0.000 0.292 0.708
L40.2 Acrodermatitis continua
0.705 0.294 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.296 0.704
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.306 0.694
E14.2 Withrenal complications
0.000 0.312 0.688
M35.7 Hypermobility syndrome
0.000 0.316 0.684
E15 Nondiabetic hypoglycaemic coma
0.000 0.327 0.673
E14.7 With multiple complications
0.000 0.330 0.670
E14.0 With coma
0.000 0.330 0.670
E53 Deficiency of other B group vitamins
0.000 0.332 0.668
E11.0 With coma
0.000 0.334 0.666
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.341 0.659
E51 Thiamine deficiency
0.000 0.345 0.655
E05.8 Other thyrotoxicosis
0.000 0.346 0.654
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.352 0.648
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.358 0.642
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.358 0.642
E16.4 Abnormal secretion of gastrin
0.000 0.358 0.642
E16.3 Increased secretion of glucagon
0.000 0.358 0.642
E16.1 Other hypoglycaemia
0.000 0.363 0.637
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.364 0.636
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.364 0.636
M35.5 Multifocal fibrosclerosis
0.000 0.364 0.636
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.364 0.636
E03.1 Congenital hypothyroidism without goitre
0.000 0.367 0.633
E58 Dietary calcium deficiency
0.000 0.367 0.633
K90 Intestinal malabsorption
0.000 0.371 0.629
E11.3 With ophthalmic complications
0.000 0.372 0.628
E13 Other specified diabetes mellitus
0.000 0.376 0.624
E07.1 Dyshormogenetic goitre
0.000 0.379 0.620
E07.0 Hypersecretion of calcitonin
0.000 0.379 0.620
E10.8 With unspecified complications
0.000 0.382 0.618
E06 Thyroiditis
0.000 0.396 0.604
M06.4 Inflammatory polyarthropathy
0.000 0.399 0.601
E56 Other vitamin deficiencies
0.000 0.404 0.596
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.408 0.592
E63 Other nutritional deficiencies
0.000 0.408 0.592
E50 Vitamin A deficiency
0.000 0.408 0.592
E60 Dietary zinc deficiency
0.000 0.408 0.592
E59 Dietary selenium deficiency
0.000 0.408 0.592
E54 Ascorbic acid deficiency
0.000 0.408 0.592
E52 Niacin deficiency [pellagra]
0.000 0.408 0.592
E14.5 With peripheral circulatory complications
0.000 0.409 0.590
E07.8 Other specified disorders of thyroid
0.000 0.410 0.590
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.419 0.581
E53.8 Deficiency of other specified B group vitamins
0.000 0.429 0.571
E11.7 With multiple complications
0.000 0.430 0.570
E55 Vitamin D deficiency
0.000 0.431 0.569
E14.4 With neurological complications
0.000 0.432 0.568
E20-E35 Disorders of other endocrine glands
0.000 0.446 0.554
E11.6 With other specified complications
0.000 0.449 0.551
M35.8 Other specified systemic involvement of connective tissue
0.000 0.451 0.549
E03.8 Other specified hypothyroidism
0.000 0.454 0.546
M05-M14 Inflammatory polyarthropathies
0.000 0.456 0.544
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.458 0.542
E61 Deficiency of other nutrient elements
0.000 0.458 0.541
M05 Seropositive rheumatoid arthritis
0.000 0.459 0.541
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.459 0.541
E11.5 With peripheral circulatory complications
0.000 0.461 0.539
E51.2 Wernicke's encephalopathy
0.000 0.467 0.533
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.468 0.532
M06.8 Other specified rheumatoid arthritis
0.000 0.469 0.531
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.491 0.509
M06.2 Rheumatoid bursitis
0.000 0.492 0.508
M06.1 Adult-onset Still's disease
0.000 0.492 0.508
E40-E46 Malnutrition
0.000 0.493 0.507
M06.3 Rheumatoid nodule
0.000 0.496 0.504
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.503 0.497
E21.3 Hyperparathyroidism, unspecified
0.000 0.507 0.493
E53.1 Pyridoxine deficiency
0.000 0.521 0.479
E53.0 Riboflavin deficiency
0.000 0.521 0.479
E51.9 Thiamine deficiency, unspecified
0.000 0.530 0.470
E51.8 Other manifestations of thiamine deficiency
0.000 0.530 0.470
E51.1 Beriberi
0.000 0.530 0.470
E11.8 With unspecified complications
0.000 0.537 0.463
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified
0.000 0.544 0.456
E14.9 Without complications
0.000 0.545 0.455
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.547 0.453
K90.3 Pancreatic steatorrhoea
0.000 0.549 0.451
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.549 0.451
K90.1 Tropical sprue
0.000 0.549 0.451
E13.8 With unspecified complications
0.000 0.553 0.447
E13.7 With multiple complications
0.000 0.553 0.447
E13.6 With other specified complications
0.000 0.553 0.447
E13.5 With peripheral circulatory complications
0.000 0.553 0.447
E13.4 With neurological complications
0.000 0.553 0.447
E13.2 With renal complications
0.000 0.553 0.447
E13.1 With ketoacidosis
0.000 0.553 0.447
E13.0 With coma
0.000 0.553 0.447
E53.9 Vitamin B deficiency, unspecified
0.000 0.553 0.447
E13.3 With ophthalmic complications
0.000 0.563 0.437
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.567 0.433
E06.4 Drug-induced thyroiditis
0.000 0.567 0.433
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.567 0.433
E06.0 Acute thyroiditis
0.000 0.567 0.433
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.569 0.431
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.569 0.431
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.569 0.431
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.569 0.431
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.569 0.431
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.569 0.431
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.569 0.431
E56.1 Deficiency of vitamin K
0.000 0.569 0.431
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.572 0.427
E56.9 Vitamin deficiency, unspecified
0.000 0.573 0.427
E56.8 Deficiency of other vitamins
0.000 0.573 0.427
E56.0 Deficiency of vitamin E
0.000 0.573 0.427
K90.9 Intestinal malabsorption, unspecified
0.000 0.573 0.427
E50.9 Vitamin A deficiency, unspecified
0.000 0.575 0.424
E50.8 Other manifestations of vitamin A deficiency
0.000 0.575 0.424
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.575 0.424
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.575 0.424
E50.5 Vitamin A deficiency with night blindness
0.000 0.575 0.424
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.575 0.424
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.575 0.424
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.575 0.424
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.575 0.424
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.575 0.424
E63.9 Nutritional deficiency, unspecified
0.000 0.575 0.424
E63.8 Other specified nutritional deficiencies
0.000 0.575 0.424
E63.1 Imbalance of constituents of food intake
0.000 0.575 0.424
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.575 0.424
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.575 0.424
E64.8 Sequelae of other nutritional deficiencies
0.000 0.575 0.424
E64.3 Sequelae of rickets
0.000 0.575 0.424
E64.2 Sequelae of vitamin C deficiency
0.000 0.575 0.424
E64.1 Sequelae of vitamin A deficiency
0.000 0.575 0.424
E64.0 Sequelae of protein-energy malnutrition
0.000 0.575 0.424
E06.5 Other chronic thyroiditis
0.000 0.579 0.421
E06.1 Subacute thyroiditis
0.000 0.586 0.414
E22 Hyperfunction of pituitary gland
0.000 0.588 0.412
M12 Other specific arthropathies
0.000 0.589 0.411
E31 Polyglandular dysfunction
0.000 0.592 0.408
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.592 0.408
E55.0 Rickets, active
0.000 0.592 0.408
E06.3 Autoimmune thyroiditis
0.000 0.593 0.407
E65-E68 Obesity and other hyperalimentation
0.000 0.594 0.406
M05.8 Other seropositive rheumatoid arthritis
0.000 0.601 0.399
E06.9 Thyroiditis, unspecified
0.000 0.602 0.398
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.603 0.397
E32 Diseases of thymus
0.000 0.603 0.397
E30 Disorders of puberty, not elsewhere classified
0.000 0.603 0.397
E21.0 Primary hyperparathyroidism
0.000 0.603 0.397
M06.34 Rheumatoid nodule (Hand)
0.000 0.605 0.395
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.607 0.393
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.610 0.390
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.611 0.389
E29 Testicular dysfunction
0.000 0.611 0.389
E61.9 Deficiency of nutrient element, unspecified
0.000 0.612 0.388
E61.8 Deficiency of other specified nutrient elements
0.000 0.612 0.388
E61.7 Deficiency of multiple nutrient elements
0.000 0.612 0.388
E61.6 Vanadium deficiency
0.000 0.612 0.388
E61.5 Molybdenum deficiency
0.000 0.612 0.388
E61.4 Chromium deficiency
0.000 0.612 0.388
E61.3 Manganese deficiency
0.000 0.612 0.388
E61.0 Copper deficiency
0.000 0.612 0.388
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.612 0.388
M05.1 Rheumatoid lung disease
0.000 0.612 0.388
M05.0 Felty's syndrome
0.000 0.612 0.388
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.612 0.388
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.612 0.388
E61.1 Iron deficiency
0.000 0.612 0.388
E24 Cushing's syndrome
0.000 0.614 0.386
E55.9 Vitamin D deficiency, unspecified
0.000 0.615 0.385
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.619 0.381
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.619 0.381
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.619 0.381
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.619 0.381
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.619 0.381
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.619 0.381
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.619 0.381
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.619 0.381
E04 Other non-toxic goitre
0.000 0.620 0.380
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.620 0.379
M05.2 Rheumatoid vasculitis
0.000 0.623 0.376
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.624 0.375
M08 Juvenile arthritis
0.000 0.626 0.374
E11.1 With ketoacidosis
0.000 0.627 0.373
E13.9 Without complications
0.000 0.630 0.370
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.632 0.368
E28 Ovarian dysfunction
0.000 0.634 0.366
K90.8 Other intestinal malabsorption
0.000 0.634 0.366
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.636 0.364
M06.18 Adult-onset Still's disease (Other)
0.000 0.636 0.364
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.636 0.364
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.636 0.364
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.636 0.364
M06.14 Adult-onset Still's disease (Hand)
0.000 0.636 0.364
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.636 0.364
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.636 0.364
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.636 0.364
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.636 0.364
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.636 0.364
M06.28 Rheumatoid bursitis (Other)
0.000 0.636 0.364
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.636 0.364
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.636 0.364
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.636 0.364
M06.24 Rheumatoid bursitis (Hand)
0.000 0.636 0.364
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.636 0.364
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.636 0.364
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.636 0.364
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.636 0.364
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.636 0.363
E45 Retarded development following protein-energy malnutrition
0.000 0.636 0.363
E43 Unspecified severe protein-energy malnutrition
0.000 0.636 0.363
E42 Marasmic kwashiorkor
0.000 0.636 0.363
E41 Nutritional marasmus
0.000 0.636 0.363
E40 Kwashiorkor
0.000 0.636 0.363
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.638 0.362
M06.38 Rheumatoid nodule (Other)
0.000 0.638 0.362
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.638 0.362
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.638 0.362
M06.33 Rheumatoid nodule (Forearm)
0.000 0.638 0.362
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.638 0.362
E20 Hypoparathyroidism
0.000 0.641 0.359
E21.2 Other hyperparathyroidism
0.000 0.643 0.357
E23 Hypofunction and other disorders of pituitary gland
0.000 0.644 0.356
M14 Arthropathies in other diseases classified elsewhere
0.000 0.648 0.352
E34 Other endocrine disorders
0.000 0.650 0.350
M10 Gout
0.000 0.650 0.350
E21.4 Other specified disorders of parathyroid gland
0.000 0.652 0.348
E27 Other disorders of adrenal gland
0.000 0.653 0.346
E25 Adrenogenital disorders
0.000 0.657 0.342
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.659 0.341
E61.2 Magnesium deficiency
0.000 0.661 0.339
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.663 0.337
E27.1 Primary adrenocortical insufficiency
0.000 0.667 0.333
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.667 0.333
M11 Other crystal arthropathies
0.000 0.675 0.325
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.681 0.319
E22.1 Hyperprolactinaemia
0.000 0.683 0.317
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.683 0.317
M12.3 Palindromic rheumatism
0.000 0.685 0.315
E11.2 With renal complications
0.000 0.694 0.306
L40-L45 Papulosquamous disorders
0.305 0.695 0.000
M12.5 Traumatic arthropathy
0.000 0.695 0.305
E31.0 Autoimmune polyglandular failure
0.000 0.696 0.304
M12.8 Other specific arthropathies, not elsewhere classified
0.000 0.697 0.302
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.699 0.301
M10.0 Idiopathic gout
0.000 0.699 0.301
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)
0.000 0.702 0.298
E04.0 Non-toxic diffuse goitre
0.000 0.703 0.297
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.704 0.296
E22.8 Other hyperfunction of pituitary gland
0.000 0.704 0.296
M12.4 Intermittent hydrarthrosis
0.000 0.705 0.295
M12.1 Kaschin-Beck disease
0.000 0.705 0.295
M12.0 Chronic postrheumatic arthropathy [Jaccoud]
0.000 0.705 0.295
E31.9 Polyglandular dysfunction, unspecified
0.000 0.707 0.293
E31.8 Other polyglandular dysfunction
0.000 0.707 0.293
E31.1 Polyglandular hyperfunction
0.000 0.707 0.293
E04.9 Non-toxic goitre, unspecified
0.000 0.708 0.292
E67 Other hyperalimentation
0.000 0.709 0.291
E68 Sequelae of hyperalimentation
0.000 0.709 0.291
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)
0.000 0.713 0.286
M05.88 Other seropositive rheumatoid arthritis (Other)
0.000 0.713 0.286
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)
0.000 0.713 0.286
M05.86 Other seropositive rheumatoid arthritis (Lower leg)
0.000 0.713 0.286
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)
0.000 0.713 0.286
M05.84 Other seropositive rheumatoid arthritis (Hand)
0.000 0.713 0.286
M05.83 Other seropositive rheumatoid arthritis (Forearm)
0.000 0.713 0.286
M05.82 Other seropositive rheumatoid arthritis (Upper arm)
0.000 0.713 0.286
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)
0.000 0.713 0.286
E30.9 Disorder of puberty, unspecified
0.000 0.715 0.285
E30.8 Other disorders of puberty
0.000 0.715 0.285
E30.1 Precocious puberty
0.000 0.715 0.285
E30.0 Delayed puberty
0.000 0.715 0.285
E32.9 Disease of thymus, unspecified
0.000 0.715 0.285
E32.8 Other diseases of thymus
0.000 0.715 0.285
E32.1 Abscess of thymus
0.000 0.715 0.285
E32.0 Persistent hyperplasia of thymus
0.000 0.715 0.285
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.715 0.285
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.715 0.285
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.715 0.285
E29.9 Testicular dysfunction, unspecified
0.000 0.718 0.282
E24.9 Cushing's syndrome, unspecified
0.000 0.720 0.280
M09.8 Juvenile arthritis in other diseases classified elsewhere
0.000 0.720 0.280
M09.2 Juvenile arthritis in ulcerative colitis
0.000 0.720 0.280
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]
0.000 0.720 0.280
M09.0 Juvenile arthritis in psoriasis
0.000 0.720 0.280
E26 Hyperaldosteronism
0.000 0.720 0.280
E24.2 Drug-induced Cushing's syndrome
0.000 0.721 0.279
E29.8 Other testicular dysfunction
0.000 0.721 0.279
E29.0 Testicular hyperfunction
0.000 0.721 0.279
M05.09 Felty's syndrome (Site unspecified)
0.000 0.721 0.278
M05.08 Felty's syndrome (Other)
0.000 0.721 0.278
M05.07 Felty's syndrome (Ankle and foot)
0.000 0.721 0.278
M05.06 Felty's syndrome (Lower leg)
0.000 0.721 0.278
M05.05 Felty's syndrome (Pelvic region and thigh)
0.000 0.721 0.278
M05.04 Felty's syndrome (Hand)
0.000 0.721 0.278
M05.03 Felty's syndrome (Forearm)
0.000 0.721 0.278
M05.02 Felty's syndrome (Upper arm)
0.000 0.721 0.278
M05.01 Felty's syndrome (Shoulder region)
0.000 0.721 0.278
M05.00 Felty's syndrome (Multiple sites)
0.000 0.721 0.278
M05.19 Rheumatoid lung disease (Site unspecified)
0.000 0.721 0.278
M05.18 Rheumatoid lung disease (Other)
0.000 0.721 0.278
M05.17 Rheumatoid lung disease (Ankle and foot)
0.000 0.721 0.278
M05.16 Rheumatoid lung disease (Lower leg)
0.000 0.721 0.278
M05.15 Rheumatoid lung disease (Pelvic region and thigh)
0.000 0.721 0.278
M05.14 Rheumatoid lung disease (Hand)
0.000 0.721 0.278
M05.13 Rheumatoid lung disease (Forearm)
0.000 0.721 0.278
M05.12 Rheumatoid lung disease (Upper arm)
0.000 0.721 0.278
M05.11 Rheumatoid lung disease (Shoulder region)
0.000 0.721 0.278
M05.10 Rheumatoid lung disease (Multiple sites)
0.000 0.721 0.278
M05.39 Rheumatoid arthritis with involvement of other organs and systems (Site unspecified)
0.000 0.721 0.278
M05.38 Rheumatoid arthritis with involvement of other organs and systems (Other)
0.000 0.721 0.278
M05.37 Rheumatoid arthritis with involvement of other organs and systems (Ankle and foot)
0.000 0.721 0.278
M05.36 Rheumatoid arthritis with involvement of other organs and systems (Lower leg)
0.000 0.721 0.278
M05.35 Rheumatoid arthritis with involvement of other organs and systems (Pelvic region and thigh)
0.000 0.721 0.278
M05.34 Rheumatoid arthritis with involvement of other organs and systems (Hand)
0.000 0.721 0.278
M05.33 Rheumatoid arthritis with involvement of other organs and systems (Forearm)
0.000 0.721 0.278
M05.32 Rheumatoid arthritis with involvement of other organs and systems (Upper arm)
0.000 0.721 0.278
M05.31 Rheumatoid arthritis with involvement of other organs and systems (Shoulder region)
0.000 0.721 0.278
M05.30 Rheumatoid arthritis with involvement of other organs and systems (Multiple sites)
0.000 0.721 0.278
E24.8 Other Cushing's syndrome
0.000 0.723 0.277
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.723 0.277
E24.3 Ectopic ACTH syndrome
0.000 0.723 0.277
E24.1 Nelson's syndrome
0.000 0.723 0.277
M12.2 Villonodular synovitis (pigmented)
0.000 0.723 0.277
M10.07 Idiopathic gout (Ankle and foot)
0.000 0.726 0.274
E04.8 Other specified non-toxic goitre
0.000 0.727 0.272
M05.28 Rheumatoid vasculitis (Other)
0.000 0.730 0.270
M05.27 Rheumatoid vasculitis (Ankle and foot)
0.000 0.730 0.270
M05.26 Rheumatoid vasculitis (Lower leg)
0.000 0.730 0.270
M05.25 Rheumatoid vasculitis (Pelvic region and thigh)
0.000 0.730 0.270
M05.24 Rheumatoid vasculitis (Hand)
0.000 0.730 0.270
M05.23 Rheumatoid vasculitis (Forearm)
0.000 0.730 0.270
M05.22 Rheumatoid vasculitis (Upper arm)
0.000 0.730 0.270
M05.21 Rheumatoid vasculitis (Shoulder region)
0.000 0.730 0.270
M05.29 Rheumatoid vasculitis (Site unspecified)
0.000 0.731 0.268
M08.9 Juvenile arthritis, unspecified
0.000 0.732 0.268
M08.8 Other juvenile arthritis
0.000 0.732 0.268
M08.4 Pauciarticular juvenile arthritis
0.000 0.732 0.268
M08.3 Juvenile polyarthritis (seronegative)
0.000 0.732 0.268
M08.2 Juvenile arthritis with systemic onset
0.000 0.732 0.268
M08.1 Juvenile ankylosing spondylitis
0.000 0.732 0.268
E29.1 Testicular hypofunction
0.000 0.733 0.267
E28.9 Ovarian dysfunction, unspecified
0.000 0.737 0.263
E28.8 Other ovarian dysfunction
0.000 0.737 0.263
E28.1 Androgen excess
0.000 0.737 0.263
E28.0 Oestrogen excess
0.000 0.737 0.263
E34.3 Short stature, not elsewhere classified
0.000 0.738 0.262
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.738 0.261
E22.0 Acromegaly and pituitary gigantism
0.000 0.738 0.262
E44.1 Mild protein-energy malnutrition
0.000 0.739 0.261
E44.0 Moderate protein-energy malnutrition
0.000 0.739 0.261
E24.0 Pituitary-dependent Cushing's disease
0.000 0.740 0.260
M05.20 Rheumatoid vasculitis (Multiple sites)
0.000 0.740 0.260
E28.3 Primary ovarian failure
0.000 0.742 0.258
M14.2 Diabetic arthropathy
0.000 0.742 0.258
E20.8 Other hypoparathyroidism
0.000 0.743 0.257
E20.1 Pseudohypoparathyroidism
0.000 0.743 0.257
E20.0 Idiopathic hypoparathyroidism
0.000 0.743 0.257
M12.39 Palindromic rheumatism (Site unspecified)
0.000 0.743 0.257
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.745 0.255
E23.1 Drug-induced hypopituitarism
0.000 0.745 0.255
E23.7 Disorder of pituitary gland, unspecified
0.000 0.747 0.253
E23.0 Hypopituitarism
0.000 0.747 0.253
M14.8 Arthropathies in other specified diseases classified elsewhere
0.000 0.747 0.252
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders
0.000 0.747 0.252
M14.4 Arthropathy in amyloidosis
0.000 0.747 0.252
M14.3 Lipoid dermatoarthritis
0.000 0.747 0.252
M14.1 Crystal arthropathy in other metabolic disorders
0.000 0.747 0.252
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders
0.000 0.747 0.252
M08.0 Juvenile rheumatoid arthritis
0.000 0.748 0.252
E34.5 Androgen resistance syndrome
0.000 0.749 0.251
E34.4 Constitutional tall stature
0.000 0.749 0.251
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.749 0.251
E34.1 Other hypersecretion of intestinal hormones
0.000 0.749 0.251
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.749 0.251
M10.4 Other secondary gout
0.000 0.749 0.251
M10.3 Gout due to impairment of renal function
0.000 0.749 0.251
M10.2 Drug-induced gout
0.000 0.749 0.251
M10.1 Lead-induced gout
0.000 0.749 0.251
E27.5 Adrenomedullary hyperfunction
0.000 0.751 0.248
E27.0 Other adrenocortical overactivity
0.000 0.751 0.248
E25.9 Adrenogenital disorder, unspecified
0.000 0.754 0.246
E25.8 Other adrenogenital disorders
0.000 0.754 0.246
E34.9 Endocrine disorder, unspecified
0.000 0.755 0.245
L42 Pityriasis rosea
0.241 0.759 0.000
E23.6 Other disorders of pituitary gland
0.000 0.760 0.240
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.761 0.239
E34.8 Other specified endocrine disorders
0.000 0.761 0.239
E23.2 Diabetes insipidus
0.000 0.762 0.238
E28.2 Polycystic ovarian syndrome
0.000 0.762 0.238
M45 Ankylosing spondylitis
0.000 0.764 0.236
M11.1 Familial chondrocalcinosis
0.000 0.767 0.233
M11.0 Hydroxyapatite deposition disease
0.000 0.767 0.233
M12.57 Traumatic arthropathy (Ankle and foot)
0.000 0.771 0.228
M10.06 Idiopathic gout (Lower leg)
0.000 0.771 0.228
M12.38 Palindromic rheumatism (Other)
0.000 0.774 0.226
M12.37 Palindromic rheumatism (Ankle and foot)
0.000 0.774 0.226
M12.36 Palindromic rheumatism (Lower leg)
0.000 0.774 0.226
M12.35 Palindromic rheumatism (Pelvic region and thigh)
0.000 0.774 0.226
M12.34 Palindromic rheumatism (Hand)
0.000 0.774 0.226
M12.33 Palindromic rheumatism (Forearm)
0.000 0.774 0.226
M12.32 Palindromic rheumatism (Upper arm)
0.000 0.774 0.226
M12.31 Palindromic rheumatism (Shoulder region)
0.000 0.774 0.226
M12.88 Other specific arthropathies, not elsewhere classified (Other)
0.000 0.775 0.224
M11.9 Crystal arthropathy, unspecified
0.000 0.776 0.223
M11.8 Other specified crystal arthropathies
0.000 0.780 0.220
E20.9 Hypoparathyroidism, unspecified
0.000 0.781 0.219
L41 Parapsoriasis
0.219 0.781 0.000
L45 Papulosquamous disorders in diseases classified elsewhere
0.219 0.781 0.000
L44 Other papulosquamous disorders
0.219 0.781 0.000
M12.59 Traumatic arthropathy (Site unspecified)
0.000 0.781 0.219
M12.58 Traumatic arthropathy (Other)
0.000 0.781 0.219
M12.56 Traumatic arthropathy (Lower leg)
0.000 0.781 0.219
M12.55 Traumatic arthropathy (Pelvic region and thigh)
0.000 0.781 0.219
M12.54 Traumatic arthropathy (Hand)
0.000 0.781 0.219
M12.53 Traumatic arthropathy (Forearm)
0.000 0.781 0.219
M12.52 Traumatic arthropathy (Upper arm)
0.000 0.781 0.219
M12.51 Traumatic arthropathy (Shoulder region)
0.000 0.781 0.219
M12.50 Traumatic arthropathy (Multiple sites)
0.000 0.781 0.219
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.782 0.218

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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