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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3131070
log Bayes Factor = 53.9654
Chromosome 6   position 28,906,531  (GRCh37) Explore rs3131070 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
E10.9 Without complications
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.003 0.997
E16.2 Hypoglycaemia, unspecified
0.000 0.004 0.996
E10.3 With ophthalmic complications
0.000 0.004 0.996
E10-E14 Diabetes mellitus
0.000 0.005 0.995
E16 Other disorders of pancreatic internal secretion
0.000 0.005 0.995
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.006 0.994
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.006 0.994
E00-E07 Disorders of thyroid gland
0.000 0.008 0.992
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.053 0.947
E10.2 With renal complications
0.000 0.054 0.946
E10.1 With ketoacidosis
0.000 0.069 0.931
E10.4 With neurological complications
0.000 0.095 0.905
E05.8 Other thyrotoxicosis
0.000 0.186 0.814
E16.1 Other hypoglycaemia
0.000 0.220 0.780
E13 Other specified diabetes mellitus
0.000 0.224 0.776
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.233 0.767
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.762 0.238 0.000
E10.7 With multiple complications
0.000 0.250 0.750
E05.5 Thyroid crisis or storm
0.000 0.285 0.715
E05.4 Thyrotoxicosis factitia
0.000 0.285 0.715
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.285 0.715
E12 Malnutrition-related diabetes mellitus
0.000 0.286 0.714
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.286 0.713
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.286 0.713
E16.4 Abnormal secretion of gastrin
0.000 0.286 0.713
E16.3 Increased secretion of glucagon
0.000 0.286 0.713
E15 Nondiabetic hypoglycaemic coma
0.000 0.287 0.713
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.289 0.711
E00 Congenital iodine-deficiency syndrome
0.000 0.289 0.711
E10.0 With coma
0.000 0.304 0.696
E10.5 With peripheral circulatory complications
0.000 0.318 0.682
E10.6 With other specified complications
0.000 0.329 0.671
E40-E46 Malnutrition
0.000 0.337 0.663
E14 Unspecified diabetes mellitus
0.000 0.357 0.643
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.363 0.637
E13.9 Without complications
0.000 0.385 0.615
E07 Other disorders of thyroid
0.000 0.399 0.601
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.426 0.574
E06 Thyroiditis
0.000 0.432 0.567
E13.3 With ophthalmic complications
0.000 0.439 0.561
E13.8 With unspecified complications
0.000 0.443 0.556
E13.7 With multiple complications
0.000 0.443 0.556
E13.6 With other specified complications
0.000 0.443 0.556
E13.5 With peripheral circulatory complications
0.000 0.443 0.556
E13.4 With neurological complications
0.000 0.443 0.556
E13.2 With renal complications
0.000 0.443 0.556
E13.1 With ketoacidosis
0.000 0.443 0.556
E13.0 With coma
0.000 0.443 0.556
E14.1 With ketoacidosis
0.000 0.480 0.520
E14.3 With ophthalmic complications
0.000 0.482 0.518
E12.9 Without complications
0.000 0.488 0.512
E12.8 With unspecified complications
0.000 0.488 0.512
E12.7 With multiple complications
0.000 0.488 0.512
E12.6 With other specified complications
0.000 0.488 0.512
E12.5 With peripheral circulatory complications
0.000 0.488 0.512
E12.4 With neurological complications
0.000 0.488 0.512
E12.3 With ophthalmic complications
0.000 0.488 0.512
E12.2 With renal complications
0.000 0.488 0.512
E12.1 With ketoacidosis
0.000 0.488 0.512
E12.0 With coma
0.000 0.488 0.512
E10.8 With unspecified complications
0.000 0.488 0.511
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.490 0.510
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.490 0.510
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.490 0.510
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.490 0.510
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.490 0.510
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.490 0.510
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.490 0.510
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.490 0.510
E14.6 With other specified complications
0.000 0.510 0.490
E14.4 With neurological complications
0.000 0.520 0.480
E07.8 Other specified disorders of thyroid
0.000 0.522 0.478
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.525 0.475
E45 Retarded development following protein-energy malnutrition
0.000 0.525 0.475
E43 Unspecified severe protein-energy malnutrition
0.000 0.525 0.475
E42 Marasmic kwashiorkor
0.000 0.525 0.475
E41 Nutritional marasmus
0.000 0.525 0.475
E40 Kwashiorkor
0.000 0.525 0.475
E14.8 With unspecified complications
0.000 0.533 0.467
E06.9 Thyroiditis, unspecified
0.000 0.539 0.461
E14.7 With multiple complications
0.000 0.539 0.461
E14.2 Withrenal complications
0.000 0.559 0.441
E14.5 With peripheral circulatory complications
0.000 0.564 0.436
K90 Intestinal malabsorption
0.000 0.568 0.432
E14.0 With coma
0.000 0.568 0.432
E07.1 Dyshormogenetic goitre
0.000 0.569 0.431
E07.0 Hypersecretion of calcitonin
0.000 0.569 0.431
E03 Other hypothyroidism
0.000 0.572 0.428
E46 Unspecified protein-energy malnutrition
0.000 0.575 0.425
E06.1 Subacute thyroiditis
0.000 0.589 0.411
E06.4 Drug-induced thyroiditis
0.000 0.593 0.407
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.593 0.407
E06.0 Acute thyroiditis
0.000 0.593 0.407
E06.5 Other chronic thyroiditis
0.000 0.609 0.391
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.609 0.390
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.631 0.369
E44.1 Mild protein-energy malnutrition
0.000 0.659 0.341
E44.0 Moderate protein-energy malnutrition
0.000 0.659 0.341
E65-E68 Obesity and other hyperalimentation
0.000 0.674 0.325
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.679 0.321
E50-E64 Other nutritional deficiencies
0.000 0.681 0.319
K90.3 Pancreatic steatorrhoea
0.000 0.690 0.310
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.690 0.310
K90.1 Tropical sprue
0.000 0.690 0.310
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.692 0.308
E11 Non-insulin-dependent diabetes mellitus
0.000 0.692 0.308
E03.5 Myxoedema coma
0.000 0.693 0.307
E03.4 Atrophy of thyroid (acquired)
0.000 0.693 0.307
E03.3 Postinfectious hypothyroidism
0.000 0.693 0.307
K90.8 Other intestinal malabsorption
0.000 0.703 0.297
E03.1 Congenital hypothyroidism without goitre
0.000 0.704 0.296
E11.6 With other specified complications
0.000 0.723 0.277
E11.1 With ketoacidosis
0.000 0.734 0.266
E11.0 With coma
0.000 0.744 0.256
E03.8 Other specified hypothyroidism
0.000 0.750 0.250
E11.2 With renal complications
0.000 0.759 0.241
E67 Other hyperalimentation
0.000 0.766 0.233
E68 Sequelae of hyperalimentation
0.000 0.766 0.233
E54 Ascorbic acid deficiency
0.000 0.767 0.233
M45.X9 Ankylosing spondylitis (Site unspecified)
0.230 0.770 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.771 0.229
E63 Other nutritional deficiencies
0.000 0.771 0.229
E50 Vitamin A deficiency
0.000 0.771 0.229
E60 Dietary zinc deficiency
0.000 0.771 0.229
E59 Dietary selenium deficiency
0.000 0.771 0.229
E52 Niacin deficiency [pellagra]
0.000 0.771 0.229
E51 Thiamine deficiency
0.000 0.772 0.228
E11.7 With multiple complications
0.000 0.779 0.221
K90.9 Intestinal malabsorption, unspecified
0.000 0.782 0.217
E56 Other vitamin deficiencies
0.000 0.784 0.216
E07.9 Disorder of thyroid, unspecified
0.000 0.784 0.216
E55 Vitamin D deficiency
0.000 0.787 0.213
E83 Disorders of mineral metabolism
0.164 0.799 0.038
E58 Dietary calcium deficiency
0.000 0.801 0.199
E11.8 With unspecified complications
0.000 0.816 0.183
E65 Localised adiposity
0.000 0.823 0.177
E20-E35 Disorders of other endocrine glands
0.000 0.825 0.175
E67.8 Other specified hyperalimentation
0.000 0.832 0.167
E67.3 Hypervitaminosis D
0.000 0.832 0.167
E67.2 Megavitamin-B6 syndrome
0.000 0.832 0.167
E67.1 Hypercarotenaemia
0.000 0.832 0.167
E67.0 Hypervitaminosis A
0.000 0.832 0.167
E61 Deficiency of other nutrient elements
0.000 0.835 0.165
E50.9 Vitamin A deficiency, unspecified
0.000 0.836 0.164
E50.8 Other manifestations of vitamin A deficiency
0.000 0.836 0.164
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.836 0.164
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.836 0.164
E50.5 Vitamin A deficiency with night blindness
0.000 0.836 0.164
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.836 0.164
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.836 0.164
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.836 0.164
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.836 0.164
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.836 0.164
E63.9 Nutritional deficiency, unspecified
0.000 0.836 0.164
E63.8 Other specified nutritional deficiencies
0.000 0.836 0.164
E63.1 Imbalance of constituents of food intake
0.000 0.836 0.164
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.836 0.164
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.836 0.164
E64.8 Sequelae of other nutritional deficiencies
0.000 0.836 0.164
E64.3 Sequelae of rickets
0.000 0.836 0.164
E64.2 Sequelae of vitamin C deficiency
0.000 0.836 0.164
E64.1 Sequelae of vitamin A deficiency
0.000 0.836 0.164
E64.0 Sequelae of protein-energy malnutrition
0.000 0.836 0.164
E51.9 Thiamine deficiency, unspecified
0.000 0.836 0.163
E51.8 Other manifestations of thiamine deficiency
0.000 0.836 0.163
E51.1 Beriberi
0.000 0.836 0.163
E51.2 Wernicke's encephalopathy
0.000 0.838 0.162
E24 Cushing's syndrome
0.000 0.841 0.159
I83 Varicose veins of lower extremities
0.158 0.842 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.000 0.843 0.157
E56.9 Vitamin deficiency, unspecified
0.000 0.845 0.155
E56.8 Deficiency of other vitamins
0.000 0.845 0.155
E56.0 Deficiency of vitamin E
0.000 0.845 0.155
E53 Deficiency of other B group vitamins
0.000 0.845 0.155
E55.0 Rickets, active
0.000 0.847 0.153
E70-E90 Metabolic disorders
0.001 0.849 0.150
E83.3 Disorders of phosphorus metabolism
0.139 0.851 0.009
E83.8 Other disorders of mineral metabolism
0.118 0.855 0.027
E83.2 Disorders of zinc metabolism
0.118 0.855 0.027
E83.0 Disorders of copper metabolism
0.118 0.855 0.027
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.855 0.145
E83.9 Disorder of mineral metabolism, unspecified
0.117 0.857 0.026
E56.1 Deficiency of vitamin K
0.000 0.857 0.142
E78.2 Mixed hyperlipidaemia
0.000 0.859 0.141
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.859 0.141
E06.3 Autoimmune thyroiditis
0.001 0.859 0.140
E03.9 Hypothyroidism, unspecified
0.000 0.859 0.141
E55.9 Vitamin D deficiency, unspecified
0.000 0.863 0.137
E24.9 Cushing's syndrome, unspecified
0.000 0.863 0.137
E21.3 Hyperparathyroidism, unspecified
0.000 0.868 0.132
E24.0 Pituitary-dependent Cushing's disease
0.000 0.868 0.132
E20 Hypoparathyroidism
0.000 0.869 0.131
E14.9 Without complications
0.000 0.869 0.131
E11.5 With peripheral circulatory complications
0.000 0.870 0.130
E78.1 Pure hyperglyceridaemia
0.000 0.873 0.127
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.875 0.125
E32 Diseases of thymus
0.000 0.875 0.125
E30 Disorders of puberty, not elsewhere classified
0.000 0.875 0.125
E28 Ovarian dysfunction
0.000 0.875 0.125
E25 Adrenogenital disorders
0.000 0.875 0.125
E31 Polyglandular dysfunction
0.000 0.877 0.123
E88 Other metabolic disorders
0.000 0.879 0.120
E24.2 Drug-induced Cushing's syndrome
0.000 0.880 0.120
E78.5 Hyperlipidaemia, unspecified
0.000 0.880 0.120
E61.9 Deficiency of nutrient element, unspecified
0.000 0.881 0.119
E61.8 Deficiency of other specified nutrient elements
0.000 0.881 0.119
E61.7 Deficiency of multiple nutrient elements
0.000 0.881 0.119
E61.6 Vanadium deficiency
0.000 0.881 0.119
E61.5 Molybdenum deficiency
0.000 0.881 0.119
E61.4 Chromium deficiency
0.000 0.881 0.119
E61.3 Manganese deficiency
0.000 0.881 0.119
E61.0 Copper deficiency
0.000 0.881 0.119
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.881 0.118
E78.6 Lipoprotein deficiency
0.000 0.884 0.116
E74 Other disorders of carbohydrate metabolism
0.001 0.884 0.116
E85 Amyloidosis
0.001 0.884 0.115
E53.9 Vitamin B deficiency, unspecified
0.000 0.886 0.114
E24.8 Other Cushing's syndrome
0.000 0.886 0.114
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.886 0.114
E24.3 Ectopic ACTH syndrome
0.000 0.886 0.114
E24.1 Nelson's syndrome
0.000 0.886 0.114
M45 Ankylosing spondylitis
0.112 0.888 0.000
E53.1 Pyridoxine deficiency
0.000 0.889 0.111
E53.0 Riboflavin deficiency
0.000 0.889 0.111
E84 Cystic fibrosis
0.001 0.890 0.109
E78.3 Hyperchylomicronaemia
0.000 0.891 0.109
I83.0 Varicose veins of lower extremities with ulcer
0.109 0.891 0.000
E29 Testicular dysfunction
0.000 0.891 0.109
E77 Disorders of glycoprotein metabolism
0.001 0.891 0.108
E76 Disorders of glycosaminoglycan metabolism
0.001 0.891 0.108
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.891 0.108
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.891 0.108
E73 Lactose intolerance
0.001 0.892 0.107
E21.2 Other hyperparathyroidism
0.000 0.894 0.106
E61.2 Magnesium deficiency
0.000 0.895 0.105
E88.9 Metabolic disorder, unspecified
0.000 0.896 0.104
E70 Disorders of aromatic amino-acid metabolism
0.001 0.897 0.103
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.102 0.898 0.000
E79 Disorders of purine and pyrimidine metabolism
0.001 0.898 0.101
E21.4 Other specified disorders of parathyroid gland
0.000 0.899 0.101
E20.9 Hypoparathyroidism, unspecified
0.000 0.900 0.100
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.901 0.099
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.901 0.099
E72 Other disorders of amino-acid metabolism
0.001 0.901 0.098
E85.4 Organ-limited amyloidosis
0.000 0.902 0.098
E34 Other endocrine disorders
0.000 0.904 0.096
E88.2 Lipomatosis, not elsewhere classified
0.000 0.905 0.095
E20.8 Other hypoparathyroidism
0.000 0.906 0.094
E20.1 Pseudohypoparathyroidism
0.000 0.906 0.094
E20.0 Idiopathic hypoparathyroidism
0.000 0.906 0.094
E75.5 Other lipid storage disorders
0.001 0.906 0.094
E28.2 Polycystic ovarian syndrome
0.000 0.906 0.094
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.907 0.093
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.907 0.092
E30.9 Disorder of puberty, unspecified
0.000 0.910 0.090
E30.8 Other disorders of puberty
0.000 0.910 0.090
E30.1 Precocious puberty
0.000 0.910 0.090
E30.0 Delayed puberty
0.000 0.910 0.090
E32.9 Disease of thymus, unspecified
0.000 0.910 0.090
E32.8 Other diseases of thymus
0.000 0.910 0.090
E32.1 Abscess of thymus
0.000 0.910 0.090
E32.0 Persistent hyperplasia of thymus
0.000 0.910 0.090
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.910 0.090
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.910 0.090
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.910 0.090
E28.9 Ovarian dysfunction, unspecified
0.000 0.910 0.090
E28.8 Other ovarian dysfunction
0.000 0.910 0.090
E28.1 Androgen excess
0.000 0.910 0.090
E28.0 Oestrogen excess
0.000 0.910 0.090
E25.9 Adrenogenital disorder, unspecified
0.000 0.910 0.090
E25.8 Other adrenogenital disorders
0.000 0.910 0.090
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.911 0.089
E31.9 Polyglandular dysfunction, unspecified
0.000 0.911 0.088
E31.8 Other polyglandular dysfunction
0.000 0.911 0.088
E31.1 Polyglandular hyperfunction
0.000 0.911 0.088
M45.X2 Ankylosing spondylitis (Cervical region)
0.088 0.911 0.000
E85.3 Secondary systemic amyloidosis
0.000 0.913 0.087
E75.2 Other sphingolipidosis
0.001 0.913 0.086
I77 Other disorders of arteries and arterioles
0.000 0.913 0.087
E11.3 With ophthalmic complications
0.000 0.913 0.087
M45.X6 Ankylosing spondylitis (Lumbar region)
0.086 0.914 0.000
E31.0 Autoimmune polyglandular failure
0.000 0.914 0.086
I73 Other peripheral vascular diseases
0.000 0.914 0.086
I73.9 Peripheral vascular disease, unspecified
0.000 0.914 0.086
E28.3 Primary ovarian failure
0.000 0.914 0.085
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.914 0.086
E75.6 Lipid storage disorder, unspecified
0.001 0.915 0.085
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.915 0.085
E75.3 Sphingolipidosis, unspecified
0.001 0.915 0.085
E75.1 Other gangliosidosis
0.001 0.915 0.085
E75.0 GM2 gangliosidosis
0.001 0.915 0.085
E78.4 Other hyperlipidaemia
0.000 0.915 0.085
E85.8 Other amyloidosis
0.001 0.916 0.083
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.916 0.083
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.916 0.083
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.916 0.083
E74.2 Disorders of galactose metabolism
0.001 0.916 0.083
E74.1 Disorders of fructose metabolism
0.001 0.916 0.083
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.917 0.083
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.917 0.083
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.917 0.083
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.917 0.082
E26 Hyperaldosteronism
0.000 0.918 0.082
C15 Malignant neoplasm of oesophagus
0.000 0.918 0.082
C15-C26 Malignant neoplasms of digestive organs
0.000 0.918 0.082
C20 Malignant neoplasm of rectum
0.000 0.918 0.082
I77.6 Arteritis, unspecified
0.000 0.918 0.082
I74 Arterial embolism and thrombosis
0.000 0.918 0.082
E74.0 Glycogen storage disease
0.001 0.919 0.081
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.919 0.081
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.919 0.080
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.919 0.081
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.080 0.919 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.080 0.919 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.080 0.919 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.080 0.919 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.080 0.919 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.080 0.919 0.000
E61.1 Iron deficiency
0.000 0.920 0.080
E29.9 Testicular dysfunction, unspecified
0.000 0.920 0.080
E84.8 Cystic fibrosis with other manifestations
0.001 0.921 0.078
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.921 0.078
E84.9 Cystic fibrosis, unspecified
0.001 0.921 0.078
E29.8 Other testicular dysfunction
0.000 0.922 0.078
E29.0 Testicular hyperfunction
0.000 0.922 0.078
E71.3 Disorders of fatty-acid metabolism
0.001 0.922 0.078
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.922 0.078
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.922 0.078
E71.0 Maple-syrup-urine disease
0.001 0.922 0.078
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.922 0.078
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.922 0.078
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.922 0.078
E76.2 Other mucopolysaccharidoses
0.001 0.922 0.078
E76.1 Mucopolysaccharidosis, type II
0.001 0.922 0.078
E76.0 Mucopolysaccharidosis, type I
0.001 0.922 0.078
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.922 0.078
E77.8 Other disorders of glycoprotein metabolism
0.001 0.922 0.078
E77.1 Defects in glycoprotein degradation
0.001 0.922 0.078
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.922 0.078
E88.8 Other specified metabolic disorders
0.000 0.922 0.078
E73.8 Other lactose intolerance
0.001 0.922 0.077
E73.1 Secondary lactase deficiency
0.001 0.922 0.077
E73.0 Congenital lactase deficiency
0.001 0.922 0.077
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.923 0.077
E73.9 Lactose intolerance, unspecified
0.000 0.923 0.077
I74.5 Embolism and thrombosis of iliac artery
0.000 0.923 0.077
I72 Other aneurysm
0.000 0.924 0.076
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.926 0.074
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.926 0.074
E70.2 Disorders of tyrosine metabolism
0.001 0.926 0.074
E70.1 Other hyperphenylalaninaemias
0.001 0.926 0.074
E70.0 Classical phenylketonuria
0.001 0.926 0.074
C15.4 Middle third of oesophagus
0.000 0.926 0.074
I73.0 Raynaud's syndrome
0.000 0.926 0.074
I77.8 Other specified disorders of arteries and arterioles
0.000 0.927 0.073
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.927 0.072
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.927 0.072
E79.1 Lesch-Nyhan syndrome
0.001 0.927 0.072
C15.5 Lower third of oesophagus
0.000 0.927 0.073
E83.4 Disorders of magnesium metabolism
0.055 0.928 0.017
E88.3 Tumour lysis syndrome
0.001 0.928 0.071
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.929 0.071
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.929 0.071
E72.5 Disorders of glycine metabolism
0.001 0.929 0.071
E72.4 Disorders of ornithine metabolism
0.001 0.929 0.071
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.929 0.071
E72.2 Disorders of urea cycle metabolism
0.001 0.929 0.071
C15.9 Oesophagus, unspecified
0.000 0.930 0.070
E34.3 Short stature, not elsewhere classified
0.000 0.930 0.070
E22 Hyperfunction of pituitary gland
0.000 0.930 0.070
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.930 0.070
E72.0 Disorders of amino-acid transport
0.001 0.931 0.069
E70.3 Albinism
0.001 0.931 0.068
E34.5 Androgen resistance syndrome
0.000 0.931 0.069
E34.4 Constitutional tall stature
0.000 0.931 0.069
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.931 0.069
E34.1 Other hypersecretion of intestinal hormones
0.000 0.931 0.069
E23 Hypofunction and other disorders of pituitary gland
0.000 0.932 0.068
I77.1 Stricture of artery
0.000 0.932 0.068
I70 Atherosclerosis
0.000 0.932 0.068
E78.8 Other disorders of lipoprotein metabolism
0.000 0.933 0.067
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.934 0.065
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.066 0.934 0.000
I77.3 Arterial fibromuscular dysplasia
0.000 0.934 0.066
I72.4 Aneurysm of artery of lower extremity
0.000 0.935 0.065
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.935 0.065
C25 Malignant neoplasm of pancreas
0.000 0.935 0.065
E34.8 Other specified endocrine disorders
0.000 0.935 0.064
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.936 0.063
I73.8 Other specified peripheral vascular diseases
0.000 0.936 0.064
E21.0 Primary hyperparathyroidism
0.000 0.936 0.064
I72.3 Aneurysm of iliac artery
0.000 0.936 0.064
C15.0 Cervical part of oesophagus
0.000 0.936 0.064
I77.2 Rupture of artery
0.000 0.937 0.063
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.937 0.063
I77.5 Necrosis of artery
0.000 0.938 0.062
I77.4 Coeliac artery compression syndrome
0.000 0.938 0.062
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.940 0.060
E34.9 Endocrine disorder, unspecified
0.000 0.940 0.060
I72.0 Aneurysm of carotid artery
0.000 0.940 0.060
C15.1 Thoracic part of oesophagus
0.000 0.940 0.060
C15.3 Upper third of oesophagus
0.000 0.940 0.060
E29.1 Testicular hypofunction
0.000 0.940 0.060
E85.9 Amyloidosis, unspecified
0.001 0.940 0.059
E26.8 Other hyperaldosteronism
0.000 0.941 0.059
E26.1 Secondary hyperaldosteronism
0.000 0.941 0.059
I72.1 Aneurysm of artery of upper extremity
0.000 0.941 0.059
C15.8 Overlapping lesion of oesophagus
0.000 0.941 0.059
C15.2 Abdominal part of oesophagus
0.000 0.941 0.059
E23.7 Disorder of pituitary gland, unspecified
0.000 0.941 0.059
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.941 0.059
E78.0 Pure hypercholesterolaemia
0.000 0.941 0.059
C17 Malignant neoplasm of small intestine
0.000 0.941 0.058
E11.4 With neurological complications
0.000 0.942 0.058
I83.1 Varicose veins of lower extremities with inflammation
0.057 0.943 0.000
E34.0 Carcinoid syndrome
0.000 0.943 0.057
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.943 0.056
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.000 0.944 0.056
C17.0 Duodenum
0.000 0.945 0.055
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.945 0.055
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.945 0.055
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.945 0.055
I72.9 Aneurysm of unspecified site
0.000 0.946 0.054
C25.3 Pancreatic duct
0.000 0.946 0.054
C25.2 Tail of pancreas
0.000 0.946 0.054
C21 Malignant neoplasm of anus and anal canal
0.000 0.948 0.052
E26.9 Hyperaldosteronism, unspecified
0.001 0.948 0.052
I70.1 Atherosclerosis of renal artery
0.000 0.948 0.052
I70.8 Atherosclerosis of other arteries
0.000 0.949 0.051
C25.1 Body of pancreas
0.000 0.949 0.051
C25.8 Overlapping lesion of pancreas
0.000 0.949 0.051
C25.4 Endocrine pancreas
0.000 0.950 0.050
I72.2 Aneurysm of renal artery
0.000 0.950 0.050
E22.8 Other hyperfunction of pituitary gland
0.000 0.950 0.050
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.951 0.049
E23.1 Drug-induced hypopituitarism
0.000 0.951 0.049
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.951 0.049
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.951 0.049
C24.0 Extrahepatic bile duct
0.000 0.951 0.049
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.952 0.048
E22.1 Hyperprolactinaemia
0.000 0.952 0.048
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.953 0.047
I79.1 Aortitis in diseases classified elsewhere
0.000 0.953 0.047
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.953 0.047
I72.8 Aneurysm of other specified arteries
0.000 0.953 0.047
I70.9 Generalised and unspecified atherosclerosis
0.000 0.954 0.046
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.955 0.045
I70.0 Atherosclerosis of aorta
0.000 0.955 0.044
E80.2 Other porphyria
0.001 0.957 0.043
C25.7 Other parts of pancreas
0.000 0.957 0.042
C17.8 Overlapping lesion of small intestine
0.000 0.958 0.042
C17.3 Meckel's diverticulum
0.000 0.958 0.042
E04 Other non-toxic goitre
0.002 0.958 0.039
C25.9 Pancreas, unspecified
0.000 0.959 0.041
I70.10 Atherosclerosis of renal artery (without gangrene)
0.000 0.959 0.041
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.959 0.040
E80.5 Crigler-Najjar syndrome
0.001 0.959 0.040
E80.3 Defects of catalase and peroxydase
0.001 0.959 0.040
E80.0 Hereditary erythropoietic porphyria
0.001 0.959 0.040
C21.8 Overlapping lesion of rectum, anus and anal canal
0.000 0.959 0.041
C24.8 Overlapping lesion of biliary tract
0.000 0.959 0.040
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.960 0.040
I70.80 Atherosclerosis of other arteries (without gangrene)
0.000 0.960 0.040
C24.9 Biliary tract, unspecified
0.000 0.962 0.038
C21.2 Cloacogenic zone
0.000 0.962 0.038
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.962 0.038
C17.1 Jejunum
0.000 0.962 0.037
I70.11 Atherosclerosis of renal artery (with gangrene)
0.000 0.962 0.037
I70.81 Atherosclerosis of other arteries (with gangrene)
0.000 0.963 0.037
I77.0 Arteriovenous fistula, acquired
0.000 0.964 0.036
C26 Malignant neoplasm of other and ill-defined digestive organs
0.000 0.964 0.036
I78 Diseases of capillaries
0.000 0.964 0.035
E80.6 Other disorders of bilirubin metabolism
0.001 0.965 0.034
R31 Unspecified haematuria
0.034 0.966 0.000
C23 Malignant neoplasm of gallbladder
0.000 0.966 0.034
E22.0 Acromegaly and pituitary gigantism
0.000 0.966 0.034
E80.1 Porphyria cutanea tarda
0.001 0.966 0.033
E83.5 Disorders of calcium metabolism
0.005 0.966 0.029
I74.8 Embolism and thrombosis of other arteries
0.000 0.966 0.034
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.966 0.033
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.000 0.967 0.033
E23.6 Other disorders of pituitary gland
0.000 0.967 0.033
C21.0 Anus, unspecified
0.000 0.967 0.033
E23.2 Diabetes insipidus
0.000 0.968 0.032
C21.1 Anal canal
0.000 0.968 0.032
I70.01 Atherosclerosis of aorta (with gangrene)
0.000 0.968 0.032
E26.0 Primary hyperaldosteronism
0.001 0.968 0.031
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.000 0.969 0.031
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.000 0.969 0.030
E04.8 Other specified non-toxic goitre
0.002 0.970 0.028
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.970 0.030
E53.8 Deficiency of other specified B group vitamins
0.000 0.972 0.028
E66 Obesity
0.000 0.972 0.028
C17.9 Small intestine, unspecified
0.000 0.972 0.028
C17.2 Ileum
0.000 0.972 0.028

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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