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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3131628
log Bayes Factor = 66.4042
Chromosome 6   position 31,502,767  (GRCh37) Explore rs3131628 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.001 0.999
I20 Angina pectoris
0.000 0.003 0.997
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.004 0.996
E14.3 With ophthalmic complications
0.000 0.011 0.989
I20.9 Angina pectoris, unspecified
0.000 0.011 0.989
E14.9 Without complications
0.000 0.011 0.989
I25.5 Ischaemic cardiomyopathy
0.000 0.012 0.988
E10.1 With ketoacidosis
0.000 0.013 0.987
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.014 0.986
E10.4 With neurological complications
0.000 0.017 0.983
I22 Subsequent myocardial infarction
0.000 0.019 0.981
I20.0 Unstable angina
0.000 0.022 0.978
I25.2 Old myocardial infarction
0.000 0.029 0.971
I21 Acute myocardial infarction
0.000 0.032 0.968
G35-G37 Demyelinating diseases of the central nervous system
0.968 0.032 0.000
E83.1 Disorders of iron metabolism
0.966 0.034 0.000
G37 Other demyelinating diseases of central nervous system
0.962 0.038 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.047 0.953
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.049 0.951
G37.9 Demyelinating disease of central nervous system, unspecified
0.945 0.055 0.000
E70-E90 Metabolic disorders
0.000 0.056 0.944
I21.9 Acute myocardial infarction, unspecified
0.000 0.064 0.936
R07.4 Chest pain, unspecified
0.000 0.065 0.935
E13 Other specified diabetes mellitus
0.000 0.071 0.929
I10 Essential (primary) hypertension
0.000 0.072 0.928
I24 Other acute ischaemic heart diseases
0.000 0.073 0.927
E78.8 Other disorders of lipoprotein metabolism
0.000 0.088 0.912
L40-L45 Papulosquamous disorders
0.000 0.107 0.893
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.117 0.883
E10.2 With renal complications
0.000 0.118 0.882
E13.9 Without complications
0.000 0.122 0.878
E11.2 With renal complications
0.000 0.125 0.875
L43 Lichen planus
0.000 0.129 0.871
E11.0 With coma
0.000 0.135 0.865
E00-E07 Disorders of thyroid gland
0.000 0.138 0.862
I21.4 Acute subendocardial myocardial infarction
0.000 0.152 0.848
I25.3 Aneurysm of heart
0.000 0.154 0.846
I10-I15 Hypertensive diseases
0.000 0.154 0.846
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.155 0.845
G37.8 Other specified demyelinating diseases of central nervous system
0.844 0.156 0.000
L40.8 Other psoriasis
0.000 0.159 0.841
L43.9 Lichen planus, unspecified
0.000 0.159 0.841
E78.2 Mixed hyperlipidaemia
0.000 0.160 0.840
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.164 0.836
E11.1 With ketoacidosis
0.000 0.166 0.834
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.171 0.829
E03 Other hypothyroidism
0.000 0.173 0.827
E14.4 With neurological complications
0.000 0.176 0.824
E10.5 With peripheral circulatory complications
0.000 0.180 0.820
E10.8 With unspecified complications
0.000 0.180 0.820
I24.8 Other forms of acute ischaemic heart disease
0.000 0.182 0.818
E03.9 Hypothyroidism, unspecified
0.000 0.184 0.816
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.186 0.814
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.202 0.798
E10.0 With coma
0.000 0.207 0.793
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.783 0.217 0.000
E85 Amyloidosis
0.000 0.222 0.778
L40.0 Psoriasis vulgaris
0.000 0.223 0.777
I23 Certain current complications following acute myocardial infarction
0.000 0.225 0.775
E16 Other disorders of pancreatic internal secretion
0.000 0.230 0.770
E11.6 With other specified complications
0.000 0.231 0.769
E05.9 Thyrotoxicosis, unspecified
0.000 0.235 0.765
E78.6 Lipoprotein deficiency
0.000 0.252 0.748
I15 Secondary hypertension
0.000 0.256 0.744
L43.8 Other lichen planus
0.000 0.262 0.738
E74 Other disorders of carbohydrate metabolism
0.000 0.264 0.736
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.265 0.735
E14.5 With peripheral circulatory complications
0.000 0.266 0.734
E10.6 With other specified complications
0.000 0.266 0.734
E78.5 Hyperlipidaemia, unspecified
0.000 0.275 0.725
E14.6 With other specified complications
0.000 0.279 0.721
E78.1 Pure hyperglyceridaemia
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.2 Withrenal complications
0.000 0.283 0.717
E14.1 With ketoacidosis
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.293 0.707
I12 Hypertensive renal disease
0.000 0.296 0.704
E16.2 Hypoglycaemia, unspecified
0.000 0.300 0.700
G36 Other acute disseminated demyelination
0.697 0.302 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.303 0.697
E11.5 With peripheral circulatory complications
0.000 0.303 0.697
L40.3 Pustulosis palmaris et plantaris
0.000 0.305 0.694
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.306 0.694
G37.5 Concentric sclerosis [Balo]
0.689 0.310 0.000
G37.4 Subacute necrotising myelitis
0.689 0.310 0.000
G37.2 Central pontine myelinolysis
0.689 0.310 0.000
G37.1 Central demyelination of corpus callosum
0.689 0.310 0.000
G37.0 Diffuse sclerosis
0.689 0.310 0.000
E79 Disorders of purine and pyrimidine metabolism
0.000 0.322 0.677
E77 Disorders of glycoprotein metabolism
0.000 0.323 0.677
E76 Disorders of glycosaminoglycan metabolism
0.000 0.323 0.677
E72 Other disorders of amino-acid metabolism
0.000 0.323 0.677
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.323 0.677
E70 Disorders of aromatic amino-acid metabolism
0.000 0.323 0.677
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.323 0.677
I15.1 Hypertension secondary to other renal disorders
0.000 0.326 0.674
E78.4 Other hyperlipidaemia
0.000 0.330 0.670
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.332 0.668
E13.8 With unspecified complications
0.000 0.334 0.666
E13.7 With multiple complications
0.000 0.334 0.666
E13.6 With other specified complications
0.000 0.334 0.666
E13.5 With peripheral circulatory complications
0.000 0.334 0.666
E13.4 With neurological complications
0.000 0.334 0.666
E13.3 With ophthalmic complications
0.000 0.334 0.666
E13.2 With renal complications
0.000 0.334 0.666
E13.1 With ketoacidosis
0.000 0.334 0.666
E13.0 With coma
0.000 0.334 0.666
E85.9 Amyloidosis, unspecified
0.000 0.340 0.660
I22.8 Subsequent myocardial infarction of other sites
0.000 0.341 0.659
I11 Hypertensive heart disease
0.000 0.346 0.654
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.349 0.651
L42 Pityriasis rosea
0.000 0.352 0.648
L44 Other papulosquamous disorders
0.000 0.360 0.640
L41 Parapsoriasis
0.000 0.360 0.640
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.360 0.640
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.368 0.632
I12.9 Hypertensive renal disease without renal failure
0.000 0.371 0.629
L43.3 Subacute (active) lichen planus
0.000 0.376 0.624
L43.2 Lichenoid drug reaction
0.000 0.376 0.624
L43.1 Bullous lichen planus
0.000 0.376 0.624
L43.0 Hypertrophic lichen planus
0.000 0.376 0.624
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.379 0.621
E84 Cystic fibrosis
0.000 0.380 0.620
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.382 0.618
E00 Congenital iodine-deficiency syndrome
0.000 0.382 0.618
I20.1 Angina pectoris with documented spasm
0.000 0.383 0.617
I23.8 Other current complications following acute myocardial infarction
0.000 0.386 0.614
E11.4 With neurological complications
0.000 0.388 0.612
I13 Hypertensive heart and renal disease
0.000 0.394 0.606
E15 Nondiabetic hypoglycaemic coma
0.000 0.394 0.606
E16.1 Other hypoglycaemia
0.000 0.394 0.606
E40-E46 Malnutrition
0.000 0.398 0.602
E03.5 Myxoedema coma
0.000 0.407 0.593
E03.4 Atrophy of thyroid (acquired)
0.000 0.407 0.593
E03.3 Postinfectious hypothyroidism
0.000 0.407 0.593
E03.1 Congenital hypothyroidism without goitre
0.000 0.407 0.593
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.407 0.593
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.413 0.587
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.417 0.583
I25.4 Coronary artery aneurysm
0.000 0.419 0.581
E05.5 Thyroid crisis or storm
0.000 0.427 0.572
E05.4 Thyrotoxicosis factitia
0.000 0.427 0.572
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.427 0.572
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.427 0.572
E85.4 Organ-limited amyloidosis
0.000 0.431 0.569
E07 Other disorders of thyroid
0.000 0.437 0.563
E85.8 Other amyloidosis
0.000 0.442 0.558
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.442 0.558
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.442 0.558
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.442 0.558
E11.3 With ophthalmic complications
0.000 0.443 0.557
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.444 0.556
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.444 0.556
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.444 0.556
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.444 0.556
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.444 0.556
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.444 0.556
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.444 0.556
Chapter IX Diseases of the circulatory system
0.000 0.445 0.555
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.448 0.552
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.448 0.552
E16.4 Abnormal secretion of gastrin
0.000 0.448 0.552
E16.3 Increased secretion of glucagon
0.000 0.448 0.552
E73 Lactose intolerance
0.000 0.449 0.551
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.452 0.548
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.452 0.548
E85.3 Secondary systemic amyloidosis
0.000 0.454 0.546
E89.3 Postprocedural hypopituitarism
0.000 0.456 0.544
I15.8 Other secondary hypertension
0.000 0.467 0.533
I15.2 Hypertension secondary to endocrine disorders
0.000 0.467 0.533
I15.0 Renovascular hypertension
0.000 0.467 0.533
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.467 0.533
I24.1 Dressler's syndrome
0.000 0.471 0.529
E06 Thyroiditis
0.000 0.471 0.529
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.472 0.528
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.472 0.528
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.472 0.528
E74.2 Disorders of galactose metabolism
0.000 0.472 0.528
E74.1 Disorders of fructose metabolism
0.000 0.472 0.528
E74.0 Glycogen storage disease
0.000 0.472 0.528
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.473 0.527
I15.9 Seconday hypertension, unspecified
0.000 0.477 0.523
E83 Disorders of mineral metabolism
0.392 0.481 0.127
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.484 0.516
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.493 0.507
G36.0 Neuromyelitis optica [Devic]
0.504 0.496 0.000
E11.8 With unspecified complications
0.000 0.499 0.501
G36.9 Acute disseminated demyelination, unspecified
0.500 0.500 0.000
G36.8 Other specified acute disseminated demyelination
0.500 0.500 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.500 0.500 0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.513 0.486
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.514 0.486
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.514 0.486
E79.1 Lesch-Nyhan syndrome
0.000 0.514 0.486
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.515 0.485
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.515 0.485
E70.3 Albinism
0.000 0.515 0.485
E70.2 Disorders of tyrosine metabolism
0.000 0.515 0.485
E70.1 Other hyperphenylalaninaemias
0.000 0.515 0.485
E70.0 Classical phenylketonuria
0.000 0.515 0.485
E71.3 Disorders of fatty-acid metabolism
0.000 0.515 0.485
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.515 0.485
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.515 0.485
E71.0 Maple-syrup-urine disease
0.000 0.515 0.485
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.515 0.485
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.515 0.485
E72.5 Disorders of glycine metabolism
0.000 0.515 0.485
E72.4 Disorders of ornithine metabolism
0.000 0.515 0.485
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.515 0.485
E72.2 Disorders of urea cycle metabolism
0.000 0.515 0.485
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.515 0.485
E72.0 Disorders of amino-acid transport
0.000 0.515 0.485
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.515 0.485
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.515 0.485
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.515 0.485
E76.2 Other mucopolysaccharidoses
0.000 0.515 0.485
E76.1 Mucopolysaccharidosis, type II
0.000 0.515 0.485
E76.0 Mucopolysaccharidosis, type I
0.000 0.515 0.485
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.515 0.485
E77.8 Other disorders of glycoprotein metabolism
0.000 0.515 0.485
E77.1 Defects in glycoprotein degradation
0.000 0.515 0.485
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.515 0.485
E75.6 Lipid storage disorder, unspecified
0.000 0.521 0.479
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.521 0.479
E75.3 Sphingolipidosis, unspecified
0.000 0.521 0.479
E75.2 Other sphingolipidosis
0.000 0.521 0.479
E75.1 Other gangliosidosis
0.000 0.521 0.479
E75.0 GM2 gangliosidosis
0.000 0.521 0.479
E75.5 Other lipid storage disorders
0.000 0.530 0.469
E88 Other metabolic disorders
0.000 0.530 0.469
E05.8 Other thyrotoxicosis
0.000 0.531 0.469
L41.9 Parapsoriasis, unspecified
0.000 0.541 0.459
L41.8 Other parapsoriasis
0.000 0.541 0.459
L41.5 Retiform parapsoriasis
0.000 0.541 0.459
L41.4 Large plaque parapsoriasis
0.000 0.541 0.459
L41.3 Small plaque parapsoriasis
0.000 0.541 0.459
L41.2 Lymphomatoid papulosis
0.000 0.541 0.459
L41.1 Pityriasis lichenoides chronica
0.000 0.541 0.459
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.541 0.459
L44.9 Papulosquamous disorder, unspecified
0.000 0.541 0.459
L44.8 Other specified papulosquamous disorders
0.000 0.541 0.459
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.541 0.459
L44.3 Lichen ruber moniliformis
0.000 0.541 0.459
L44.2 Lichen striatus
0.000 0.541 0.459
L44.1 Lichen nitidus
0.000 0.541 0.459
L44.0 Pityriasis rubra pilaris
0.000 0.541 0.459
E65-E68 Obesity and other hyperalimentation
0.000 0.544 0.456
E50-E64 Other nutritional deficiencies
0.000 0.549 0.451
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.555 0.445
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.555 0.445
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.555 0.445
E89.5 Postprocedural testicular hypofunction
0.000 0.555 0.445
E89.1 Postprocedural hypoinsulinaemia
0.000 0.555 0.445
E84.8 Cystic fibrosis with other manifestations
0.000 0.555 0.444
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.555 0.444
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.555 0.444
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.557 0.443
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.557 0.443
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.557 0.443
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.557 0.443
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.557 0.443
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.557 0.443
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.557 0.443
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.557 0.443
I12.0 Hypertensive renal disease with renal failure
0.000 0.562 0.438
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.565 0.435
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.565 0.435
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.565 0.435
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.565 0.435
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.568 0.431
E45 Retarded development following protein-energy malnutrition
0.000 0.568 0.431
E43 Unspecified severe protein-energy malnutrition
0.000 0.568 0.431
E42 Marasmic kwashiorkor
0.000 0.568 0.431
E41 Nutritional marasmus
0.000 0.568 0.431
E40 Kwashiorkor
0.000 0.568 0.431
E89.4 Postprocedural ovarian failure
0.000 0.582 0.418
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.582 0.417
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.588 0.411
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.594 0.406
E07.1 Dyshormogenetic goitre
0.000 0.596 0.404
E07.0 Hypersecretion of calcitonin
0.000 0.596 0.404
E07.8 Other specified disorders of thyroid
0.000 0.598 0.402
I00-I02 Acute rheumatic fever
0.000 0.602 0.398
E73.8 Other lactose intolerance
0.000 0.605 0.395
E73.1 Secondary lactase deficiency
0.000 0.605 0.395
E73.0 Congenital lactase deficiency
0.000 0.605 0.395
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.605 0.395
E89.2 Postprocedural hypoparathyroidism
0.000 0.607 0.393
K90 Intestinal malabsorption
0.000 0.610 0.390
E84.9 Cystic fibrosis, unspecified
0.001 0.612 0.387
E80.6 Other disorders of bilirubin metabolism
0.000 0.619 0.381
E06.5 Other chronic thyroiditis
0.000 0.621 0.379
E06.4 Drug-induced thyroiditis
0.000 0.621 0.379
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.621 0.379
E06.1 Subacute thyroiditis
0.000 0.621 0.379
E06.0 Acute thyroiditis
0.000 0.621 0.379
E83.3 Disorders of phosphorus metabolism
0.340 0.621 0.039
E88.2 Lipomatosis, not elsewhere classified
0.000 0.626 0.373
E83.9 Disorder of mineral metabolism, unspecified
0.281 0.628 0.091
E83.8 Other disorders of mineral metabolism
0.281 0.628 0.091
E83.2 Disorders of zinc metabolism
0.281 0.628 0.091
E83.0 Disorders of copper metabolism
0.281 0.628 0.091
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.636 0.364
E80.5 Crigler-Najjar syndrome
0.000 0.636 0.364
E80.3 Defects of catalase and peroxydase
0.000 0.636 0.364
E80.2 Other porphyria
0.000 0.636 0.364
E80.1 Porphyria cutanea tarda
0.000 0.636 0.364
E80.0 Hereditary erythropoietic porphyria
0.000 0.636 0.364
E06.9 Thyroiditis, unspecified
0.000 0.640 0.360
E61 Deficiency of other nutrient elements
0.000 0.647 0.353
E46 Unspecified protein-energy malnutrition
0.000 0.648 0.351
E03.8 Other specified hypothyroidism
0.001 0.649 0.351
E07.9 Disorder of thyroid, unspecified
0.000 0.649 0.351
E88.8 Other specified metabolic disorders
0.000 0.662 0.338
E88.9 Metabolic disorder, unspecified
0.000 0.663 0.336
E88.3 Tumour lysis syndrome
0.000 0.667 0.333
E67 Other hyperalimentation
0.000 0.673 0.327
E68 Sequelae of hyperalimentation
0.000 0.673 0.327
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.676 0.323
E63 Other nutritional deficiencies
0.000 0.676 0.323
E56 Other vitamin deficiencies
0.000 0.676 0.323
E51 Thiamine deficiency
0.000 0.676 0.323
E50 Vitamin A deficiency
0.000 0.676 0.323
E60 Dietary zinc deficiency
0.000 0.676 0.323
E59 Dietary selenium deficiency
0.000 0.676 0.323
E58 Dietary calcium deficiency
0.000 0.676 0.323
E54 Ascorbic acid deficiency
0.000 0.676 0.323
E52 Niacin deficiency [pellagra]
0.000 0.676 0.323
E65 Localised adiposity
0.000 0.682 0.318
E06.3 Autoimmune thyroiditis
0.000 0.683 0.317
E44.1 Mild protein-energy malnutrition
0.000 0.690 0.309
E44.0 Moderate protein-energy malnutrition
0.000 0.690 0.309
E61.1 Iron deficiency
0.000 0.711 0.289
I02 Rheumatic chorea
0.000 0.714 0.286
I01 Rheumatic fever with heart involvement
0.000 0.714 0.286
I00 Rheumatic fever without mention of heart involvement
0.000 0.714 0.286
E20-E35 Disorders of other endocrine glands
0.000 0.715 0.285
K90.9 Intestinal malabsorption, unspecified
0.000 0.719 0.281
K90.3 Pancreatic steatorrhoea
0.000 0.720 0.280
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.720 0.280
K90.1 Tropical sprue
0.000 0.720 0.280
K90.8 Other intestinal malabsorption
0.000 0.720 0.280
E88.1 Lipodystrophy, not elsewhere classified
0.001 0.728 0.271
E73.9 Lactose intolerance, unspecified
0.001 0.730 0.269
E89.0 Postprocedural hypothyroidism
0.000 0.734 0.266
E55 Vitamin D deficiency
0.000 0.743 0.257
E61.9 Deficiency of nutrient element, unspecified
0.000 0.747 0.253
E61.8 Deficiency of other specified nutrient elements
0.000 0.747 0.253
E61.7 Deficiency of multiple nutrient elements
0.000 0.747 0.253
E61.6 Vanadium deficiency
0.000 0.747 0.253
E61.5 Molybdenum deficiency
0.000 0.747 0.253
E61.4 Chromium deficiency
0.000 0.747 0.253
E61.3 Manganese deficiency
0.000 0.747 0.253
E61.0 Copper deficiency
0.000 0.747 0.253
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.749 0.251
E61.2 Magnesium deficiency
0.000 0.758 0.242
E23 Hypofunction and other disorders of pituitary gland
0.000 0.763 0.237
E67.8 Other specified hyperalimentation
0.000 0.765 0.235
E67.3 Hypervitaminosis D
0.000 0.765 0.235
E67.2 Megavitamin-B6 syndrome
0.000 0.765 0.235
E67.1 Hypercarotenaemia
0.000 0.765 0.235
E67.0 Hypervitaminosis A
0.000 0.765 0.235
E50.9 Vitamin A deficiency, unspecified
0.000 0.768 0.232
E50.8 Other manifestations of vitamin A deficiency
0.000 0.768 0.232
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.768 0.232
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.768 0.232
E50.5 Vitamin A deficiency with night blindness
0.000 0.768 0.232
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.768 0.232
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.768 0.232
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.768 0.232
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.768 0.232
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.768 0.232
E51.9 Thiamine deficiency, unspecified
0.000 0.768 0.232
E51.8 Other manifestations of thiamine deficiency
0.000 0.768 0.232
E51.2 Wernicke's encephalopathy
0.000 0.768 0.232
E51.1 Beriberi
0.000 0.768 0.232
E56.9 Vitamin deficiency, unspecified
0.000 0.768 0.232
E56.8 Deficiency of other vitamins
0.000 0.768 0.232
E56.1 Deficiency of vitamin K
0.000 0.768 0.232
E56.0 Deficiency of vitamin E
0.000 0.768 0.232
E63.9 Nutritional deficiency, unspecified
0.000 0.768 0.232
E63.8 Other specified nutritional deficiencies
0.000 0.768 0.232
E63.1 Imbalance of constituents of food intake
0.000 0.768 0.232
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.768 0.232
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.768 0.232
E64.8 Sequelae of other nutritional deficiencies
0.000 0.768 0.232
E64.3 Sequelae of rickets
0.000 0.768 0.232
E64.2 Sequelae of vitamin C deficiency
0.000 0.768 0.232
E64.1 Sequelae of vitamin A deficiency
0.000 0.768 0.232
E64.0 Sequelae of protein-energy malnutrition
0.000 0.768 0.232
E22 Hyperfunction of pituitary gland
0.000 0.772 0.228
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.001 0.779 0.220
E83.4 Disorders of magnesium metabolism
0.128 0.789 0.083
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.795 0.205
I01.8 Other acute rheumatic heart disease
0.000 0.795 0.205
I01.2 Acute rheumatic myocarditis
0.000 0.795 0.205
I01.1 Acute rheumatic endocarditis
0.000 0.795 0.205
I01.0 Acute rheumatic pericarditis
0.000 0.795 0.205
I02.9 Rheumatic chorea without heart involvement
0.000 0.795 0.205
I02.0 Rheumatic chorea with heart involvement
0.000 0.795 0.205
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.795 0.204
E32 Diseases of thymus
0.000 0.795 0.204
E31 Polyglandular dysfunction
0.000 0.795 0.204
E30 Disorders of puberty, not elsewhere classified
0.000 0.795 0.204
E25 Adrenogenital disorders
0.000 0.795 0.204
E26 Hyperaldosteronism
0.000 0.799 0.201
E23.6 Other disorders of pituitary gland
0.000 0.801 0.199
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.805 0.195
E23.2 Diabetes insipidus
0.000 0.806 0.194
E29 Testicular dysfunction
0.000 0.808 0.192
E24 Cushing's syndrome
0.000 0.809 0.191
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.809 0.191
E55.0 Rickets, active
0.000 0.815 0.184
E20 Hypoparathyroidism
0.000 0.816 0.183
E23.7 Disorder of pituitary gland, unspecified
0.000 0.820 0.180
E28 Ovarian dysfunction
0.000 0.822 0.178
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.827 0.173
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.830 0.170
E23.1 Drug-induced hypopituitarism
0.000 0.830 0.170
E22.1 Hyperprolactinaemia
0.000 0.836 0.164
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.836 0.164
E22.8 Other hyperfunction of pituitary gland
0.000 0.836 0.164
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.001 0.841 0.158
I28 Other diseases of pulmonary vessels
0.001 0.843 0.156
E83.5 Disorders of calcium metabolism
0.125 0.847 0.027
E80.4 Gilbert's syndrome
0.001 0.848 0.152
E22.0 Acromegaly and pituitary gigantism
0.000 0.852 0.148
E34 Other endocrine disorders
0.000 0.852 0.148
E25.9 Adrenogenital disorder, unspecified
0.000 0.853 0.147
E25.8 Other adrenogenital disorders
0.000 0.853 0.147
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.853 0.147
E30.9 Disorder of puberty, unspecified
0.000 0.853 0.147
E30.8 Other disorders of puberty
0.000 0.853 0.147
E30.1 Precocious puberty
0.000 0.853 0.147
E30.0 Delayed puberty
0.000 0.853 0.147
E31.9 Polyglandular dysfunction, unspecified
0.000 0.853 0.147
E31.8 Other polyglandular dysfunction
0.000 0.853 0.147
E31.1 Polyglandular hyperfunction
0.000 0.853 0.147
E31.0 Autoimmune polyglandular failure
0.000 0.853 0.147
E32.9 Disease of thymus, unspecified
0.000 0.853 0.147
E32.8 Other diseases of thymus
0.000 0.853 0.147
E32.1 Abscess of thymus
0.000 0.853 0.147
E32.0 Persistent hyperplasia of thymus
0.000 0.853 0.147
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.853 0.147
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.853 0.147
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.853 0.147
E21.3 Hyperparathyroidism, unspecified
0.000 0.853 0.147
E53 Deficiency of other B group vitamins
0.001 0.854 0.145
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.855 0.145
E26.9 Hyperaldosteronism, unspecified
0.000 0.856 0.144
E26.8 Other hyperaldosteronism
0.000 0.856 0.144
E26.1 Secondary hyperaldosteronism
0.000 0.856 0.144
E26.0 Primary hyperaldosteronism
0.000 0.860 0.140
E29.9 Testicular dysfunction, unspecified
0.000 0.862 0.137
E29.8 Other testicular dysfunction
0.000 0.862 0.137
E29.0 Testicular hyperfunction
0.000 0.862 0.137
E24.8 Other Cushing's syndrome
0.000 0.863 0.137
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.863 0.137
E24.3 Ectopic ACTH syndrome
0.000 0.863 0.137
E24.2 Drug-induced Cushing's syndrome
0.000 0.863 0.137
E24.1 Nelson's syndrome
0.000 0.863 0.137
E24.0 Pituitary-dependent Cushing's disease
0.000 0.863 0.137
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.863 0.137
E21.4 Other specified disorders of parathyroid gland
0.000 0.863 0.137
E21.2 Other hyperparathyroidism
0.000 0.863 0.137
I05-I09 Chronic rheumatic heart diseases
0.000 0.865 0.135

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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