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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3131635
log Bayes Factor = 91.725
Chromosome 6   position 31,476,134  (GRCh37) Explore rs3131635 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
J45.9 Asthma, unspecified
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.003 0.997
E14.3 With ophthalmic complications
0.000 0.003 0.997
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.003 0.997
E05.9 Thyrotoxicosis, unspecified
0.000 0.003 0.997
E10.4 With neurological complications
0.000 0.004 0.996
E10.1 With ketoacidosis
0.000 0.007 0.993
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.009 0.991
E14.9 Without complications
0.000 0.017 0.983
M45 Ankylosing spondylitis
0.000 0.050 0.950
L40 Psoriasis
0.937 0.063 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.069 0.931
E11 Non-insulin-dependent diabetes mellitus
0.000 0.073 0.927
E11.9 Without complications
0.000 0.088 0.912
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.088 0.912
E10.2 With renal complications
0.000 0.094 0.906
G35-G37 Demyelinating diseases of the central nervous system
0.902 0.098 0.000
L40.0 Psoriasis vulgaris
0.894 0.106 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.116 0.884
G37 Other demyelinating diseases of central nervous system
0.884 0.116 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.124 0.876
E13 Other specified diabetes mellitus
0.000 0.137 0.863
L40.5 Arthropathic psoriasis
0.863 0.137 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.862 0.138 0.000
E10.0 With coma
0.000 0.159 0.841
E10.5 With peripheral circulatory complications
0.000 0.171 0.829
E11.0 With coma
0.000 0.186 0.814
E07 Other disorders of thyroid
0.000 0.199 0.801
E16.2 Hypoglycaemia, unspecified
0.000 0.203 0.797
E14.6 With other specified complications
0.000 0.208 0.792
E10.8 With unspecified complications
0.000 0.216 0.784
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.217 0.783
E14.1 With ketoacidosis
0.000 0.221 0.779
G37.8 Other specified demyelinating diseases of central nervous system
0.773 0.227 0.000
E13.9 Without complications
0.000 0.235 0.765
E14.8 With unspecified complications
0.000 0.237 0.763
E11.6 With other specified complications
0.000 0.246 0.754
E06 Thyroiditis
0.000 0.261 0.739
E83.1 Disorders of iron metabolism
0.727 0.273 0.000
E14.5 With peripheral circulatory complications
0.000 0.279 0.721
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.2 Withrenal complications
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.712 0.288 0.000
E10.6 With other specified complications
0.000 0.303 0.697
E11.1 With ketoacidosis
0.000 0.306 0.694
E07.9 Disorder of thyroid, unspecified
0.000 0.311 0.689
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.315 0.685
E14.4 With neurological complications
0.000 0.315 0.685
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.319 0.681
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.319 0.681
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.319 0.681
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.319 0.681
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.319 0.681
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.319 0.681
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.319 0.681
L40.4 Guttate psoriasis
0.672 0.328 0.000
L40.2 Acrodermatitis continua
0.672 0.328 0.000
E15 Nondiabetic hypoglycaemic coma
0.000 0.332 0.668
E11.7 With multiple complications
0.000 0.335 0.664
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.355 0.645
E16.1 Other hypoglycaemia
0.000 0.358 0.642
L40.3 Pustulosis palmaris et plantaris
0.642 0.358 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.366 0.634
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.366 0.634
E16.4 Abnormal secretion of gastrin
0.000 0.366 0.634
E16.3 Increased secretion of glucagon
0.000 0.366 0.634
G37.5 Concentric sclerosis [Balo]
0.634 0.366 0.000
G37.4 Subacute necrotising myelitis
0.634 0.366 0.000
G37.2 Central pontine myelinolysis
0.634 0.366 0.000
G37.1 Central demyelination of corpus callosum
0.634 0.366 0.000
G37.0 Diffuse sclerosis
0.634 0.366 0.000
G36 Other acute disseminated demyelination
0.620 0.380 0.000
E05.8 Other thyrotoxicosis
0.000 0.380 0.620
E13.8 With unspecified complications
0.000 0.381 0.619
E13.7 With multiple complications
0.000 0.381 0.619
E13.6 With other specified complications
0.000 0.381 0.619
E13.5 With peripheral circulatory complications
0.000 0.381 0.619
E13.4 With neurological complications
0.000 0.381 0.619
E13.3 With ophthalmic complications
0.000 0.381 0.619
E13.2 With renal complications
0.000 0.381 0.619
E13.1 With ketoacidosis
0.000 0.381 0.619
E13.0 With coma
0.000 0.381 0.619
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.384 0.616
K90 Intestinal malabsorption
0.000 0.415 0.585
E11.5 With peripheral circulatory complications
0.000 0.416 0.584
E40-E46 Malnutrition
0.000 0.417 0.583
E07.1 Dyshormogenetic goitre
0.000 0.425 0.575
E07.0 Hypersecretion of calcitonin
0.000 0.425 0.575
E06.9 Thyroiditis, unspecified
0.000 0.426 0.574
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.560 0.440 0.000
L40.8 Other psoriasis
0.547 0.453 0.000
E65-E68 Obesity and other hyperalimentation
0.000 0.467 0.533
E11.2 With renal complications
0.000 0.469 0.531
E06.5 Other chronic thyroiditis
0.000 0.470 0.530
E06.4 Drug-induced thyroiditis
0.000 0.470 0.530
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.470 0.530
E06.1 Subacute thyroiditis
0.000 0.470 0.530
E06.0 Acute thyroiditis
0.000 0.470 0.530
E07.8 Other specified disorders of thyroid
0.000 0.485 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E06.3 Autoimmune thyroiditis
0.000 0.497 0.503
E50-E64 Other nutritional deficiencies
0.000 0.498 0.502
K90.9 Intestinal malabsorption, unspecified
0.000 0.505 0.495
K90.8 Other intestinal malabsorption
0.000 0.538 0.462
E03.8 Other specified hypothyroidism
0.001 0.550 0.450
G36.9 Acute disseminated demyelination, unspecified
0.445 0.555 0.000
G36.8 Other specified acute disseminated demyelination
0.445 0.555 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.445 0.555 0.000
E11.3 With ophthalmic complications
0.000 0.572 0.428
E11.8 With unspecified complications
0.001 0.580 0.419
K90.3 Pancreatic steatorrhoea
0.000 0.581 0.419
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.581 0.419
K90.1 Tropical sprue
0.000 0.581 0.419
G36.0 Neuromyelitis optica [Devic]
0.418 0.581 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.582 0.418
E45 Retarded development following protein-energy malnutrition
0.000 0.582 0.418
E43 Unspecified severe protein-energy malnutrition
0.000 0.582 0.418
E42 Marasmic kwashiorkor
0.000 0.582 0.418
E41 Nutritional marasmus
0.000 0.582 0.418
E40 Kwashiorkor
0.000 0.582 0.418
E11.4 With neurological complications
0.000 0.583 0.417
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.597 0.403
E67 Other hyperalimentation
0.000 0.617 0.382
E68 Sequelae of hyperalimentation
0.000 0.617 0.382
E61 Deficiency of other nutrient elements
0.000 0.626 0.374
E65 Localised adiposity
0.000 0.629 0.370
E58 Dietary calcium deficiency
0.000 0.630 0.369
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.639 0.361
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.640 0.360
E63 Other nutritional deficiencies
0.000 0.640 0.360
E51 Thiamine deficiency
0.000 0.640 0.360
E50 Vitamin A deficiency
0.000 0.640 0.360
E60 Dietary zinc deficiency
0.000 0.640 0.360
E59 Dietary selenium deficiency
0.000 0.640 0.360
E54 Ascorbic acid deficiency
0.000 0.640 0.360
E52 Niacin deficiency [pellagra]
0.000 0.640 0.360
E56 Other vitamin deficiencies
0.000 0.654 0.346
E55 Vitamin D deficiency
0.000 0.670 0.330
E44.1 Mild protein-energy malnutrition
0.000 0.700 0.300
E44.0 Moderate protein-energy malnutrition
0.000 0.700 0.300
E61.2 Magnesium deficiency
0.000 0.709 0.291
E46 Unspecified protein-energy malnutrition
0.000 0.714 0.286
E67.8 Other specified hyperalimentation
0.000 0.726 0.274
E67.3 Hypervitaminosis D
0.000 0.726 0.274
E67.2 Megavitamin-B6 syndrome
0.000 0.726 0.274
E67.1 Hypercarotenaemia
0.000 0.726 0.274
E67.0 Hypervitaminosis A
0.000 0.726 0.274
E61.9 Deficiency of nutrient element, unspecified
0.000 0.731 0.268
E61.8 Deficiency of other specified nutrient elements
0.000 0.731 0.268
E61.7 Deficiency of multiple nutrient elements
0.000 0.731 0.268
E61.6 Vanadium deficiency
0.000 0.731 0.268
E61.5 Molybdenum deficiency
0.000 0.731 0.268
E61.4 Chromium deficiency
0.000 0.731 0.268
E61.3 Manganese deficiency
0.000 0.731 0.268
E61.0 Copper deficiency
0.000 0.731 0.268
J45 Asthma
0.000 0.733 0.267
E50.9 Vitamin A deficiency, unspecified
0.000 0.741 0.258
E50.8 Other manifestations of vitamin A deficiency
0.000 0.741 0.258
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.741 0.258
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.741 0.258
E50.5 Vitamin A deficiency with night blindness
0.000 0.741 0.258
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.741 0.258
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.741 0.258
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.741 0.258
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.741 0.258
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.741 0.258
E51.9 Thiamine deficiency, unspecified
0.000 0.741 0.258
E51.8 Other manifestations of thiamine deficiency
0.000 0.741 0.258
E51.2 Wernicke's encephalopathy
0.000 0.741 0.258
E51.1 Beriberi
0.000 0.741 0.258
E63.9 Nutritional deficiency, unspecified
0.000 0.741 0.258
E63.8 Other specified nutritional deficiencies
0.000 0.741 0.258
E63.1 Imbalance of constituents of food intake
0.000 0.741 0.258
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.741 0.258
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.741 0.258
E64.8 Sequelae of other nutritional deficiencies
0.000 0.741 0.258
E64.3 Sequelae of rickets
0.000 0.741 0.258
E64.2 Sequelae of vitamin C deficiency
0.000 0.741 0.258
E64.1 Sequelae of vitamin A deficiency
0.000 0.741 0.258
E64.0 Sequelae of protein-energy malnutrition
0.000 0.741 0.258
E61.1 Iron deficiency
0.000 0.743 0.257
E56.9 Vitamin deficiency, unspecified
0.000 0.751 0.248
E56.8 Deficiency of other vitamins
0.000 0.751 0.248
E56.0 Deficiency of vitamin E
0.000 0.751 0.248
E83 Disorders of mineral metabolism
0.246 0.752 0.002
E55.0 Rickets, active
0.000 0.763 0.237
E56.1 Deficiency of vitamin K
0.000 0.765 0.234
E83.3 Disorders of phosphorus metabolism
0.232 0.768 0.000
E66 Obesity
0.000 0.775 0.225
L40-L45 Papulosquamous disorders
0.217 0.782 0.000
E55.9 Vitamin D deficiency, unspecified
0.000 0.794 0.206
M75.0 Adhesive capsulitis of shoulder
0.000 0.795 0.205
J45.1 Nonallergic asthma
0.000 0.796 0.204
E66.0 Obesity due to excess calories
0.000 0.810 0.190
E53 Deficiency of other B group vitamins
0.000 0.814 0.186
J45.8 Mixed asthma
0.000 0.820 0.180
E83.9 Disorder of mineral metabolism, unspecified
0.177 0.822 0.001
E83.8 Other disorders of mineral metabolism
0.177 0.822 0.001
E83.2 Disorders of zinc metabolism
0.177 0.822 0.001
E83.0 Disorders of copper metabolism
0.177 0.822 0.001
L44 Other papulosquamous disorders
0.162 0.837 0.000
E66.1 Drug-induced obesity
0.000 0.838 0.161
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.842 0.157
L41 Parapsoriasis
0.156 0.844 0.000
L45 Papulosquamous disorders in diseases classified elsewhere
0.156 0.844 0.000
L42 Pityriasis rosea
0.152 0.848 0.000
M75 Shoulder lesions
0.000 0.864 0.136
E53.1 Pyridoxine deficiency
0.000 0.866 0.133
E53.0 Riboflavin deficiency
0.000 0.866 0.133
M75.4 Impingement syndrome of shoulder
0.000 0.868 0.132
H36.0 Diabetic retinopathy
0.000 0.877 0.123
L44.0 Pityriasis rubra pilaris
0.123 0.877 0.000
M75.2 Bicipital tendinitis
0.000 0.878 0.122
L44.9 Papulosquamous disorder, unspecified
0.116 0.883 0.000
L44.8 Other specified papulosquamous disorders
0.116 0.883 0.000
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.116 0.883 0.000
L44.3 Lichen ruber moniliformis
0.116 0.883 0.000
L44.2 Lichen striatus
0.116 0.883 0.000
L44.1 Lichen nitidus
0.116 0.883 0.000
J45.0 Predominantly allergic asthma
0.000 0.886 0.114
L41.9 Parapsoriasis, unspecified
0.112 0.888 0.000
L41.8 Other parapsoriasis
0.112 0.888 0.000
L41.5 Retiform parapsoriasis
0.112 0.888 0.000
L41.4 Large plaque parapsoriasis
0.112 0.888 0.000
L41.3 Small plaque parapsoriasis
0.112 0.888 0.000
L41.2 Lymphomatoid papulosis
0.112 0.888 0.000
L41.1 Pityriasis lichenoides chronica
0.112 0.888 0.000
L41.0 Pityriasis lichenoides et varioliformis acuta
0.112 0.888 0.000
E66.9 Obesity, unspecified
0.000 0.890 0.110
E53.9 Vitamin B deficiency, unspecified
0.000 0.893 0.106
M75.5 Bursitis of shoulder
0.000 0.902 0.098
M75.8 Other shoulder lesions
0.000 0.902 0.097
H36 Retinal disorders in diseases classified elsewhere
0.000 0.911 0.089
E20-E35 Disorders of other endocrine glands
0.001 0.916 0.084
E83.5 Disorders of calcium metabolism
0.083 0.917 0.000
E04 Other non-toxic goitre
0.000 0.930 0.070
M75.81 Other shoulder lesions, right shoulder
0.000 0.930 0.070
M75.9 Shoulder lesion, unspecified
0.000 0.931 0.069
E22 Hyperfunction of pituitary gland
0.000 0.933 0.067
M75.3 Calcific tendinitis of shoulder
0.000 0.934 0.065
H35.8 Other specified retinal disorders
0.000 0.935 0.065
H35 Other retinal disorders
0.000 0.935 0.065
H30-H36 Disorders of choroid and retina
0.000 0.935 0.065
E29 Testicular dysfunction
0.000 0.936 0.064
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.936 0.064
L43 Lichen planus
0.060 0.938 0.002
E35 Disorders of endocrine glands in diseases classified elsewhere
0.001 0.939 0.060
E32 Diseases of thymus
0.001 0.939 0.060
E31 Polyglandular dysfunction
0.001 0.939 0.060
E30 Disorders of puberty, not elsewhere classified
0.001 0.939 0.060
E23 Hypofunction and other disorders of pituitary gland
0.000 0.940 0.059
E20 Hypoparathyroidism
0.001 0.941 0.058
H35.5 Hereditary retinal dystrophy
0.000 0.942 0.058
E24 Cushing's syndrome
0.000 0.943 0.056
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.943 0.056
H35.2 Other proliferative retinopathy
0.000 0.944 0.056
E26 Hyperaldosteronism
0.001 0.946 0.054
H35.4 Peripheral retinal degeneration
0.000 0.946 0.054
E22.1 Hyperprolactinaemia
0.000 0.946 0.054
E23.2 Diabetes insipidus
0.000 0.948 0.052
H35.7 Separation of retinal layers
0.000 0.948 0.052
E25 Adrenogenital disorders
0.001 0.948 0.052
E04.8 Other specified non-toxic goitre
0.000 0.949 0.050
M45-M49 Spondylopathies
0.000 0.949 0.051
E29.1 Testicular hypofunction
0.000 0.950 0.050
H34 Retinal vascular occlusions
0.000 0.951 0.049
E23.6 Other disorders of pituitary gland
0.000 0.951 0.049
E83.4 Disorders of magnesium metabolism
0.047 0.951 0.002
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.951 0.048
E22.8 Other hyperfunction of pituitary gland
0.000 0.951 0.048
H31 Other disorders of choroid
0.000 0.952 0.048
H35.1 Retinopathy of prematurity
0.000 0.953 0.047
E28 Ovarian dysfunction
0.001 0.953 0.046
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.953 0.046
E29.9 Testicular dysfunction, unspecified
0.000 0.954 0.046
E29.8 Other testicular dysfunction
0.000 0.954 0.046
E29.0 Testicular hyperfunction
0.000 0.954 0.046
H35.6 Retinal haemorrhage
0.000 0.955 0.045
L43.3 Subacute (active) lichen planus
0.043 0.955 0.001
L43.2 Lichenoid drug reaction
0.043 0.955 0.001
L43.1 Bullous lichen planus
0.043 0.955 0.001
L43.0 Hypertrophic lichen planus
0.043 0.955 0.001
E30.9 Disorder of puberty, unspecified
0.001 0.956 0.043
E30.8 Other disorders of puberty
0.001 0.956 0.043
E30.1 Precocious puberty
0.001 0.956 0.043
E30.0 Delayed puberty
0.001 0.956 0.043
E31.9 Polyglandular dysfunction, unspecified
0.001 0.956 0.043
E31.8 Other polyglandular dysfunction
0.001 0.956 0.043
E31.1 Polyglandular hyperfunction
0.001 0.956 0.043
E31.0 Autoimmune polyglandular failure
0.001 0.956 0.043
E32.9 Disease of thymus, unspecified
0.001 0.956 0.043
E32.8 Other diseases of thymus
0.001 0.956 0.043
E32.1 Abscess of thymus
0.001 0.956 0.043
E32.0 Persistent hyperplasia of thymus
0.001 0.956 0.043
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.001 0.956 0.043
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.001 0.956 0.043
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.001 0.956 0.043
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.957 0.043
E23.1 Drug-induced hypopituitarism
0.000 0.957 0.043
E24.0 Pituitary-dependent Cushing's disease
0.000 0.957 0.042
E20.8 Other hypoparathyroidism
0.001 0.958 0.042
E20.1 Pseudohypoparathyroidism
0.001 0.958 0.042
E20.0 Idiopathic hypoparathyroidism
0.001 0.958 0.042
E34 Other endocrine disorders
0.001 0.958 0.041
H30 Chorioretinal inflammation
0.000 0.959 0.041
H35.9 Retinal disorder, unspecified
0.000 0.959 0.041
E24.8 Other Cushing's syndrome
0.000 0.959 0.041
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.959 0.041
E24.3 Ectopic ACTH syndrome
0.000 0.959 0.041
E24.2 Drug-induced Cushing's syndrome
0.000 0.959 0.041
E24.1 Nelson's syndrome
0.000 0.959 0.041
H34.8 Other retinal vascular occlusions
0.000 0.959 0.041
E20.9 Hypoparathyroidism, unspecified
0.000 0.960 0.040
E26.9 Hyperaldosteronism, unspecified
0.001 0.961 0.039
E26.8 Other hyperaldosteronism
0.001 0.961 0.039
E26.1 Secondary hyperaldosteronism
0.001 0.961 0.039
M49 Spondylopathies in diseases classified elsewhere
0.000 0.962 0.038
E22.0 Acromegaly and pituitary gigantism
0.000 0.962 0.038
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.962 0.038
E25.9 Adrenogenital disorder, unspecified
0.001 0.962 0.037
E25.8 Other adrenogenital disorders
0.001 0.962 0.037
H31.1 Choroidal degeneration
0.000 0.962 0.037
K90-K93 Other diseases of the digestive system
0.000 0.964 0.036
E53.8 Deficiency of other specified B group vitamins
0.000 0.964 0.035
H34.0 Transient retinal artery occlusion
0.000 0.964 0.035
I22 Subsequent myocardial infarction
0.000 0.965 0.035
H35.0 Background retinopathy and retinal vascular changes
0.000 0.965 0.035
H34.2 Other retinal artery occlusions
0.000 0.965 0.035
K60.2 Anal fissure, unspecified
0.000 0.965 0.035
E24.9 Cushing's syndrome, unspecified
0.000 0.965 0.034
H31.0 Chorioretinal scars
0.000 0.965 0.034
H31.9 Disorder of choroid, unspecified
0.000 0.965 0.034
H31.4 Choroidal detachment
0.000 0.965 0.034
H31.2 Hereditary choroidal dystrophy
0.000 0.965 0.034
H34.1 Central retinal artery occlusion
0.000 0.966 0.034
E28.3 Primary ovarian failure
0.000 0.966 0.034
E23.7 Disorder of pituitary gland, unspecified
0.000 0.966 0.034
E04.0 Non-toxic diffuse goitre
0.000 0.966 0.034
E28.9 Ovarian dysfunction, unspecified
0.001 0.966 0.033
E28.8 Other ovarian dysfunction
0.001 0.966 0.033
E28.1 Androgen excess
0.001 0.966 0.033
E28.0 Oestrogen excess
0.001 0.966 0.033
H32.8 Other chorioretinal disorders in diseases classified elsewhere
0.000 0.966 0.033
H32.0 Chorioretinal inflammation in infectious and parasitic diseases classified elsewhere
0.000 0.966 0.033
H34.9 Retinal vascular occlusion, unspecified
0.000 0.966 0.034
H31.8 Other specified disorders of choroid
0.000 0.966 0.033
H31.3 Choroidal haemorrhage and rupture
0.000 0.967 0.033
E26.0 Primary hyperaldosteronism
0.001 0.967 0.032
I20-I25 Ischaemic heart diseases
0.000 0.968 0.032
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.969 0.031
M75.1 Rotator cuff syndrome
0.000 0.969 0.031
E34.5 Androgen resistance syndrome
0.001 0.970 0.030
E34.4 Constitutional tall stature
0.001 0.970 0.030
E34.3 Short stature, not elsewhere classified
0.001 0.970 0.030
E34.2 Ectopic hormone secretion, not elsewhere classified
0.001 0.970 0.030
E34.1 Other hypersecretion of intestinal hormones
0.001 0.970 0.030
H30.8 Other chorioretinal inflammations
0.000 0.970 0.030
H30.2 Posterior cyclitis
0.000 0.970 0.030
H30.1 Disseminated chorioretinal inflammation
0.000 0.970 0.030
H30.0 Focal chorioretinal inflammation
0.000 0.970 0.030
I25.5 Ischaemic cardiomyopathy
0.000 0.970 0.030
E34.8 Other specified endocrine disorders
0.001 0.971 0.029
I20.9 Angina pectoris, unspecified
0.000 0.971 0.029
I25 Chronic ischaemic heart disease
0.000 0.971 0.029
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.001 0.971 0.028
I24 Other acute ischaemic heart diseases
0.000 0.971 0.029
M49.5 Collapsed vertebra in diseases classified elsewhere
0.000 0.971 0.029
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.971 0.029
E34.0 Carcinoid syndrome
0.001 0.972 0.028
M49.8 Spondylopathy in other diseases classified elsewhere
0.000 0.972 0.027
M49.4 Neuropathic spondylopathy
0.000 0.972 0.027
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere
0.000 0.972 0.027
M49.2 Enterobacterial spondylitis
0.000 0.972 0.027
M49.1 Brucella spondylitis
0.000 0.972 0.027
M49.0 Tuberculosis of spine
0.000 0.972 0.027
I20 Angina pectoris
0.000 0.973 0.027
L43.8 Other lichen planus
0.025 0.973 0.002
I23 Certain current complications following acute myocardial infarction
0.000 0.973 0.027
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.973 0.027
I25.1 Atherosclerotic heart disease
0.000 0.973 0.027
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.974 0.026
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.974 0.026
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.974 0.026
I25.2 Old myocardial infarction
0.000 0.975 0.025
H30.9 Chorioretinal inflammation, unspecified
0.000 0.975 0.025
E04.9 Non-toxic goitre, unspecified
0.000 0.976 0.024
I23.8 Other current complications following acute myocardial infarction
0.000 0.976 0.024
M49.50 Collapsed vertebra in diseases classified elsewhere (Multiple sites in spine)
0.000 0.977 0.023
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)
0.000 0.978 0.022
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.978 0.022
I22.8 Subsequent myocardial infarction of other sites
0.000 0.979 0.021
I25.6 Silent myocardial ischaemia
0.000 0.979 0.021
M49.56 Collapsed vertebra in diseases classified elsewhere (Lumbar region)
0.000 0.979 0.021
M23.3 Other meniscus derangements
0.000 0.979 0.021
M49.59 Collapsed vertebra in diseases classified elsewhere (Site unspecified)
0.000 0.979 0.021
M49.58 Collapsed vertebra in diseases classified elsewhere (Sacral and sacrococcygeal region)
0.000 0.979 0.021
M49.57 Collapsed vertebra in diseases classified elsewhere (Lumbosacral region)
0.000 0.979 0.021
M49.55 Collapsed vertebra in diseases classified elsewhere (Thoracolumbar region)
0.000 0.979 0.021
M49.53 Collapsed vertebra in diseases classified elsewhere (Cervicothoracic region)
0.000 0.979 0.021
M49.52 Collapsed vertebra in diseases classified elsewhere (Cervical region)
0.000 0.979 0.021
M49.51 Collapsed vertebra in diseases classified elsewhere (Occipito-atlanto-axial region)
0.000 0.979 0.021
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.979 0.021
E21.4 Other specified disorders of parathyroid gland
0.000 0.979 0.021
E21.2 Other hyperparathyroidism
0.000 0.979 0.021
M46 Other inflammatory spondylopathies
0.000 0.979 0.021
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.979 0.021
M49.54 Collapsed vertebra in diseases classified elsewhere (Thoracic region)
0.000 0.979 0.021
M70-M79 Other soft tissue disorders
0.000 0.979 0.021
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.000 0.980 0.020
M49.09 Tuberculosis of spine (Site unspecified)
0.000 0.980 0.020
M49.08 Tuberculosis of spine (Sacral and sacrococcygeal region)
0.000 0.980 0.020
M49.07 Tuberculosis of spine (Lumbosacral region)
0.000 0.980 0.020
M49.06 Tuberculosis of spine (Lumbar region)
0.000 0.980 0.020
M49.05 Tuberculosis of spine (Thoracolumbar region)
0.000 0.980 0.020
M49.04 Tuberculosis of spine (Thoracic region)
0.000 0.980 0.020
M49.03 Tuberculosis of spine (Cervicothoracic region)
0.000 0.980 0.020
M49.02 Tuberculosis of spine (Cervical region)
0.000 0.980 0.020
M49.01 Tuberculosis of spine (Occipito-atlanto-axial region)
0.000 0.980 0.020
M49.00 Tuberculosis of spine (Multiple sites in spine)
0.000 0.980 0.020
M49.19 Brucella spondylitis (Site unspecified)
0.000 0.980 0.020
M49.18 Brucella spondylitis (Sacral and sacrococcygeal region)
0.000 0.980 0.020
M49.17 Brucella spondylitis (Lumbosacral region)
0.000 0.980 0.020
M49.16 Brucella spondylitis (Lumbar region)
0.000 0.980 0.020
M49.15 Brucella spondylitis (Thoracolumbar region)
0.000 0.980 0.020
M49.14 Brucella spondylitis (Thoracic region)
0.000 0.980 0.020
M49.13 Brucella spondylitis (Cervicothoracic region)
0.000 0.980 0.020
M49.12 Brucella spondylitis (Cervical region)
0.000 0.980 0.020
M49.11 Brucella spondylitis (Occipito-atlanto-axial region)
0.000 0.980 0.020
M49.10 Brucella spondylitis (Multiple sites in spine)
0.000 0.980 0.020
M49.29 Enterobacterial spondylitis (Site unspecified)
0.000 0.980 0.020
M49.28 Enterobacterial spondylitis (Sacral and sacrococcygeal region)
0.000 0.980 0.020
M49.27 Enterobacterial spondylitis (Lumbosacral region)
0.000 0.980 0.020
M49.26 Enterobacterial spondylitis (Lumbar region)
0.000 0.980 0.020
M49.25 Enterobacterial spondylitis (Thoracolumbar region)
0.000 0.980 0.020
M49.24 Enterobacterial spondylitis (Thoracic region)
0.000 0.980 0.020
M49.23 Enterobacterial spondylitis (Cervicothoracic region)
0.000 0.980 0.020
M49.22 Enterobacterial spondylitis (Cervical region)
0.000 0.980 0.020
M49.21 Enterobacterial spondylitis (Occipito-atlanto-axial region)
0.000 0.980 0.020
M49.20 Enterobacterial spondylitis (Multiple sites in spine)
0.000 0.980 0.020
M49.39 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Site unspecified)
0.000 0.980 0.020
M49.38 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Sacral and sacrococcygeal region)
0.000 0.980 0.020
M49.37 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Lumbosacral region)
0.000 0.980 0.020
M49.36 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Lumbar region)
0.000 0.980 0.020
M49.35 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Thoracolumbar region)
0.000 0.980 0.020
M49.34 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Thoracic region)
0.000 0.980 0.020
M49.33 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Cervicothoracic region)
0.000 0.980 0.020
M49.32 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Cervical region)
0.000 0.980 0.020
M49.31 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Occipito-atlanto-axial region)
0.000 0.980 0.020
M49.30 Spondylopathy in other infectious and parasitic diseases classified elsewhere (Multiple sites in spine)
0.000 0.980 0.020
M49.49 Neuropathic spondylopathy (Site unspecified)
0.000 0.980 0.020
M49.48 Neuropathic spondylopathy (Sacral and sacrococcygeal region)
0.000 0.980 0.020
M49.47 Neuropathic spondylopathy (Lumbosacral region)
0.000 0.980 0.020
M49.46 Neuropathic spondylopathy (Lumbar region)
0.000 0.980 0.020
M49.45 Neuropathic spondylopathy (Thoracolumbar region)
0.000 0.980 0.020
M49.44 Neuropathic spondylopathy (Thoracic region)
0.000 0.980 0.020
M49.43 Neuropathic spondylopathy (Cervicothoracic region)
0.000 0.980 0.020
M49.42 Neuropathic spondylopathy (Cervical region)
0.000 0.980 0.020
M49.41 Neuropathic spondylopathy (Occipito-atlanto-axial region)
0.000 0.980 0.020

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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