TreeWAS – Variant ID: rs3132453

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E10.9 Without complications	0.000	0.000	1.000
E83.1 Disorders of iron metabolism	1.000	0.000	0.000
E10 Insulin-dependent diabetes mellitus	0.000	0.000	1.000
G35 Multiple sclerosis	1.000	0.000	0.000
E10-E14 Diabetes mellitus	0.000	0.000	1.000
E78.0 Pure hypercholesterolaemia	0.000	0.000	1.000
E10.3 With ophthalmic complications	0.000	0.000	1.000
E11.9 Without complications	0.000	0.000	1.000
E11 Non-insulin-dependent diabetes mellitus	0.000	0.000	1.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.000	1.000
K90.0 Coeliac disease	0.000	0.000	1.000
L40.9 Psoriasis, unspecified	0.000	0.000	1.000
G35-G37 Demyelinating diseases of the central nervous system	0.999	0.001	0.000
E00-E07 Disorders of thyroid gland	0.000	0.002	0.998
E03.9 Hypothyroidism, unspecified	0.000	0.002	0.998
E03 Other hypothyroidism	0.000	0.002	0.998
L40 Psoriasis	0.000	0.002	0.998
I20-I25 Ischaemic heart diseases	0.000	0.003	0.997
Chapter VI Diseases of the nervous system	0.997	0.003	0.000
I25 Chronic ischaemic heart disease	0.000	0.004	0.996
L40.5 Arthropathic psoriasis	0.000	0.006	0.994
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.000	0.009	0.990
I20 Angina pectoris	0.000	0.010	0.990
E70-E90 Metabolic disorders	0.002	0.011	0.987
I10 Essential (primary) hypertension	0.000	0.017	0.983
I25.1 Atherosclerotic heart disease	0.000	0.021	0.979
I20.0 Unstable angina	0.000	0.025	0.975
E83 Disorders of mineral metabolism	0.968	0.026	0.006
E10.1 With ketoacidosis	0.000	0.026	0.974
J45.9 Asthma, unspecified	0.000	0.030	0.970
E10.4 With neurological complications	0.000	0.030	0.970
G30-G32 Other degenerative diseases of the nervous system	0.964	0.036	0.000
I22 Subsequent myocardial infarction	0.000	0.036	0.964
G37 Other demyelinating diseases of central nervous system	0.963	0.037	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.041	0.959
G90-G99 Other disorders of the nervous system	0.958	0.042	0.000
E14 Unspecified diabetes mellitus	0.000	0.047	0.953
G00-G09 Inflammatory diseases of the central nervous system	0.950	0.050	0.000
I10-I15 Hypertensive diseases	0.000	0.052	0.948
I20.9 Angina pectoris, unspecified	0.000	0.054	0.946
G31 Other degenerative diseases of nervous system, not elsewhere classified	0.943	0.057	0.000
G20-G26 Extrapyramidal and movement disorders	0.938	0.062	0.000
E83.5 Disorders of calcium metabolism	0.936	0.064	0.000
I24 Other acute ischaemic heart diseases	0.000	0.064	0.936
L40-L45 Papulosquamous disorders	0.000	0.067	0.933
E16 Other disorders of pancreatic internal secretion	0.000	0.069	0.931
I25.2 Old myocardial infarction	0.000	0.074	0.926
G31.9 Degenerative disease of nervous system, unspecified	0.926	0.074	0.000
G93 Other disorders of brain	0.922	0.078	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.000	0.082	0.918
G20 Parkinson's disease	0.912	0.088	0.000
E16.2 Hypoglycaemia, unspecified	0.000	0.091	0.909
G37.9 Demyelinating disease of central nervous system, unspecified	0.908	0.092	0.000
E14.3 With ophthalmic complications	0.000	0.100	0.900
L43 Lichen planus	0.000	0.104	0.896
I24.9 Acute ischaemic heart disease, unspecified	0.000	0.109	0.891
I22.1 Subsequent myocardial infarction of inferior wall	0.000	0.115	0.885
E83.3 Disorders of phosphorus metabolism	0.870	0.128	0.002
I25.5 Ischaemic cardiomyopathy	0.000	0.130	0.870
L43.9 Lichen planus, unspecified	0.000	0.130	0.870
G37.8 Other specified demyelinating diseases of central nervous system	0.868	0.132	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.000	0.154	0.846
E10.2 With renal complications	0.000	0.158	0.842
Chapter IX Diseases of the circulatory system	0.000	0.160	0.840
E13 Other specified diabetes mellitus	0.000	0.172	0.828
E07 Other disorders of thyroid	0.000	0.175	0.825
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.000	0.180	0.820
G80-G83 Cerebral palsy and other paralytic syndromes	0.813	0.187	0.000
G03 Meningitis due to other and unspecified causes	0.812	0.188	0.000
E14.9 Without complications	0.000	0.194	0.806
I22.0 Subsequent myocardial infarction of anterior wall	0.000	0.198	0.802
E11.5 With peripheral circulatory complications	0.000	0.198	0.802
G00 Bacterial meningitis, not elsewhere classified	0.798	0.202	0.000
I11 Hypertensive heart disease	0.000	0.205	0.795
E10.5 With peripheral circulatory complications	0.000	0.208	0.792
E78.2 Mixed hyperlipidaemia	0.000	0.209	0.791
G93.3 Postviral fatigue syndrome	0.790	0.210	0.000
I25.3 Aneurysm of heart	0.000	0.211	0.789
G93.4 Encephalopathy, unspecified	0.787	0.213	0.000
I12 Hypertensive renal disease	0.000	0.213	0.787
E11.2 With renal complications	0.000	0.217	0.783
G97 Postprocedural disorders of nervous system, not elsewhere classified	0.780	0.220	0.000
G09 Sequelae of inflammatory diseases of central nervous system	0.769	0.231	0.000
I15 Secondary hypertension	0.000	0.232	0.768
G91 Hydrocephalus	0.766	0.234	0.000
E11.1 With ketoacidosis	0.000	0.242	0.758
I20.1 Angina pectoris with documented spasm	0.000	0.243	0.757
E03.8 Other specified hypothyroidism	0.000	0.247	0.753
G04 Encephalitis, myelitis and encephalomyelitis	0.752	0.247	0.000
E11.6 With other specified complications	0.000	0.254	0.745
G99 Other disorders of nervous system in diseases classified elsewhere	0.743	0.257	0.000
E78.1 Pure hyperglyceridaemia	0.000	0.258	0.742
G31.2 Degeneration of nervous system due to alcohol	0.740	0.259	0.000
E11.8 With unspecified complications	0.000	0.260	0.740
G93.8 Other specified disorders of brain	0.732	0.268	0.000
G93.9 Disorder of brain, unspecified	0.727	0.273	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.000	0.279	0.721
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.281	0.719
G01 Meningitis in bacterial diseases classified elsewhere	0.718	0.282	0.000
G83 Other paralytic syndromes	0.718	0.282	0.000
G06 Intracranial and intraspinal abscess and granuloma	0.717	0.283	0.000
E10.8 With unspecified complications	0.000	0.283	0.717
E10.7 With multiple complications	0.000	0.283	0.717
E10.6 With other specified complications	0.000	0.283	0.717
E10.0 With coma	0.000	0.283	0.717
E12 Malnutrition-related diabetes mellitus	0.000	0.283	0.717
E11.7 With multiple complications	0.000	0.283	0.717
G36 Other acute disseminated demyelination	0.717	0.283	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.284	0.716
E00 Congenital iodine-deficiency syndrome	0.000	0.284	0.716
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.284	0.716
E03.5 Myxoedema coma	0.000	0.284	0.716
E03.4 Atrophy of thyroid (acquired)	0.000	0.284	0.716
E03.3 Postinfectious hypothyroidism	0.000	0.284	0.716
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.284	0.716
E03.1 Congenital hypothyroidism without goitre	0.000	0.284	0.716
E03.0 Congenital hypothyroidism with diffuse goitre	0.000	0.284	0.716
L40.8 Other psoriasis	0.000	0.285	0.715
L40.4 Guttate psoriasis	0.000	0.285	0.715
L40.3 Pustulosis palmaris et plantaris	0.000	0.285	0.715
L40.2 Acrodermatitis continua	0.000	0.285	0.715
L40.1 Generalised pustular psoriasis	0.000	0.285	0.715
I25.6 Silent myocardial ischaemia	0.000	0.286	0.714
I23 Certain current complications following acute myocardial infarction	0.000	0.287	0.713
G03.9 Meningitis, unspecified	0.713	0.287	0.000
E78.6 Lipoprotein deficiency	0.000	0.290	0.710
E78.3 Hyperchylomicronaemia	0.000	0.290	0.710
E84 Cystic fibrosis	0.001	0.291	0.708
E79 Disorders of purine and pyrimidine metabolism	0.001	0.291	0.708
E77 Disorders of glycoprotein metabolism	0.001	0.291	0.708
E76 Disorders of glycosaminoglycan metabolism	0.001	0.291	0.708
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.001	0.291	0.708
E74 Other disorders of carbohydrate metabolism	0.001	0.291	0.708
E72 Other disorders of amino-acid metabolism	0.001	0.291	0.708
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.001	0.291	0.708
E70 Disorders of aromatic amino-acid metabolism	0.001	0.291	0.708
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.001	0.291	0.708
E78.8 Other disorders of lipoprotein metabolism	0.000	0.291	0.708
G94 Other disorders of brain in diseases classified elsewhere	0.707	0.292	0.000
E13.9 Without complications	0.000	0.295	0.705
G96 Other disorders of central nervous system	0.704	0.296	0.000
G98 Other disorders of nervous system, not elsewhere classified	0.703	0.296	0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.703	0.296	0.000
G93.0 Cerebral cysts	0.703	0.297	0.000
G93.6 Cerebral oedema	0.701	0.299	0.000
E83.9 Disorder of mineral metabolism, unspecified	0.694	0.301	0.005
E83.8 Other disorders of mineral metabolism	0.694	0.301	0.005
E83.2 Disorders of zinc metabolism	0.694	0.301	0.005
E83.0 Disorders of copper metabolism	0.694	0.301	0.005
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.001	0.308	0.692
G32 Other degenerative disorders of nervous system in diseases classified elsewhere	0.691	0.309	0.000
G37.5 Concentric sclerosis [Balo]	0.690	0.310	0.000
G37.4 Subacute necrotising myelitis	0.690	0.310	0.000
G37.2 Central pontine myelinolysis	0.690	0.310	0.000
G37.1 Central demyelination of corpus callosum	0.690	0.310	0.000
G37.0 Diffuse sclerosis	0.690	0.310	0.000
E15 Nondiabetic hypoglycaemic coma	0.000	0.312	0.688
G92 Toxic encephalopathy	0.687	0.313	0.000
I11.9 Hypertensive heart disease without (congestive) heart failure	0.000	0.314	0.685
E14.8 With unspecified complications	0.000	0.317	0.683
E14.7 With multiple complications	0.000	0.317	0.683
E14.6 With other specified complications	0.000	0.317	0.683
E14.5 With peripheral circulatory complications	0.000	0.317	0.683
E14.2 Withrenal complications	0.000	0.317	0.683
E14.1 With ketoacidosis	0.000	0.317	0.683
E14.0 With coma	0.000	0.317	0.683
G02 Meningitis in other infectious and parasitic diseases classified elsewhere	0.681	0.319	0.000
G07 Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere	0.681	0.319	0.000
I13 Hypertensive heart and renal disease	0.000	0.320	0.680
G93.2 Benign intracranial hypertension	0.678	0.322	0.000
E11.3 With ophthalmic complications	0.000	0.322	0.678
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere	0.677	0.322	0.000
G31.1 Senile degeneration of brain, not elsewhere classified	0.676	0.324	0.000
G31.0 Circumscribed brain atrophy	0.676	0.324	0.000
E40-E46 Malnutrition	0.000	0.324	0.676
E06 Thyroiditis	0.000	0.326	0.674
E16.0 Drug-induced hypoglycaemia without coma	0.000	0.326	0.674
E78.4 Other hyperlipidaemia	0.000	0.326	0.673
G23 Other degenerative diseases of basal ganglia	0.672	0.328	0.000
G21 Secondary Parkinsonism	0.672	0.328	0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere	0.672	0.328	0.000
G22 Parkinsonism in diseases classified elsewhere	0.672	0.328	0.000
I24.1 Dressler's syndrome	0.000	0.329	0.671
L44 Other papulosquamous disorders	0.000	0.331	0.669
L41 Parapsoriasis	0.000	0.331	0.669
L45 Papulosquamous disorders in diseases classified elsewhere	0.000	0.331	0.669
L42 Pityriasis rosea	0.000	0.331	0.669
G93.1 Anoxic brain damage, not elsewhere classified	0.668	0.332	0.000
E16.9 Disorder of pancreatic internal secretion, unspecified	0.000	0.333	0.667
E16.8 Other specified disorders of pancreatic internal secretion	0.000	0.333	0.667
E16.4 Abnormal secretion of gastrin	0.000	0.333	0.667
E16.3 Increased secretion of glucagon	0.000	0.333	0.667
E16.1 Other hypoglycaemia	0.000	0.333	0.667
G99.2 Myelopathy in diseases classified elsewhere	0.666	0.334	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.001	0.334	0.665
E07.9 Disorder of thyroid, unspecified	0.000	0.337	0.662
G70-G73 Diseases of myoneural junction and muscle	0.662	0.338	0.000
G91.1 Obstructive hydrocephalus	0.662	0.338	0.000
G93.7 Reye's syndrome	0.661	0.339	0.000
G30 Alzheimer's disease	0.657	0.343	0.000
G00.9 Bacterial meningitis, unspecified	0.656	0.344	0.000
G40-G47 Episodic and paroxysmal disorders	0.655	0.345	0.000
E85 Amyloidosis	0.001	0.350	0.648
I25.4 Coronary artery aneurysm	0.000	0.352	0.648
I12.0 Hypertensive renal disease with renal failure	0.000	0.353	0.647
G93.5 Compression of brain	0.647	0.353	0.000
I22.8 Subsequent myocardial infarction of other sites	0.000	0.354	0.646
E07.8 Other specified disorders of thyroid	0.000	0.355	0.645
G31.8 Other specified degenerative diseases of nervous system	0.643	0.357	0.000
L43.8 Other lichen planus	0.000	0.357	0.642
L43.3 Subacute (active) lichen planus	0.000	0.357	0.642
L43.2 Lichenoid drug reaction	0.000	0.357	0.642
L43.1 Bullous lichen planus	0.000	0.357	0.642
L43.0 Hypertrophic lichen planus	0.000	0.357	0.642
G08 Intracranial and intraspinal phlebitis and thrombophlebitis	0.642	0.358	0.000
I15.1 Hypertension secondary to other renal disorders	0.000	0.362	0.638
E14.4 With neurological complications	0.000	0.363	0.637
M06.9 Rheumatoid arthritis, unspecified	0.000	0.367	0.633
J45 Asthma	0.000	0.367	0.633
E11.0 With coma	0.000	0.369	0.631
I21 Acute myocardial infarction	0.000	0.373	0.627
G00.1 Pneumococcal meningitis	0.624	0.376	0.000
L40.0 Psoriasis vulgaris	0.000	0.378	0.622
G25 Other extrapyramidal and movement disorders	0.619	0.381	0.000
G97.8 Other postprocedural disorders of nervous system	0.618	0.382	0.000
M06 Other rheumatoid arthritis	0.000	0.384	0.616
E89.3 Postprocedural hypopituitarism	0.000	0.389	0.611
G04.9 Encephalitis, myelitis and encephalomyelitis, unspecified	0.611	0.389	0.000
G83.4 Cauda equina syndrome	0.607	0.393	0.000
I00-I02 Acute rheumatic fever	0.000	0.398	0.602
E78.5 Hyperlipidaemia, unspecified	0.000	0.398	0.602
I12.9 Hypertensive renal disease without renal failure	0.000	0.399	0.601
# Top node	0.000	0.402	0.598
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.402	0.598
Chapter XII Diseases of the skin and subcutaneous tissue	0.000	0.402	0.598
M05-M14 Inflammatory polyarthropathies	0.000	0.404	0.596
E13.8 With unspecified complications	0.000	0.406	0.594
E13.7 With multiple complications	0.000	0.406	0.594
E13.6 With other specified complications	0.000	0.406	0.594
E13.5 With peripheral circulatory complications	0.000	0.406	0.594
E13.4 With neurological complications	0.000	0.406	0.594
E13.3 With ophthalmic complications	0.000	0.406	0.594
E13.2 With renal complications	0.000	0.406	0.594
E13.1 With ketoacidosis	0.000	0.406	0.594
E13.0 With coma	0.000	0.406	0.594
E07.1 Dyshormogenetic goitre	0.000	0.409	0.591
E07.0 Hypersecretion of calcitonin	0.000	0.409	0.591
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.000	0.410	0.590
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.414	0.586
G97.1 Other reaction to spinal and lumbar puncture	0.585	0.415	0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system	0.585	0.415	0.000
G40 Epilepsy	0.584	0.416	0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.000	0.418	0.582
G03.8 Meningitis due to other specified causes	0.582	0.418	0.000
G03.2 Benign recurrent meningitis [Mollaret]	0.582	0.418	0.000
G03.1 Chronic meningitis	0.582	0.418	0.000
G03.0 Nonpyogenic meningitis	0.582	0.418	0.000
G97.0 Cerebrospinal fluid leak from spinal puncture	0.581	0.419	0.000
G80 Infantile cerebral palsy	0.580	0.420	0.000
I21.2 Acute transmural myocardial infarction of other sites	0.000	0.422	0.578
G24 Dystonia	0.574	0.426	0.000
G11 Hereditary ataxia	0.574	0.426	0.000
G44 Other headache syndromes	0.572	0.428	0.000
G00.8 Other bacterial meningitis	0.572	0.428	0.000
G00.3 Staphylococcal meningitis	0.572	0.428	0.000
G00.2 Streptococcal meningitis	0.572	0.428	0.000
G00.0 Haemophilus meningitis	0.572	0.428	0.000
I11.0 Hypertensive heart disease with (congestive) heart failure	0.000	0.430	0.570
E73 Lactose intolerance	0.002	0.430	0.568
M07 Psoriatic and enteropathic arthropathies	0.000	0.433	0.567
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.433	0.567
G83.9 Paralytic syndrome, unspecified	0.564	0.436	0.000
G97.9 Postprocedural disorder of nervous system, unspecified	0.559	0.441	0.000
G97.2 Intracranial hypotension following ventricular shunting	0.559	0.441	0.000
G81 Hemiplegia	0.556	0.444	0.000
G90 Disorders of autonomic nervous system	0.555	0.445	0.000
E11.4 With neurological complications	0.000	0.449	0.551
I15.9 Seconday hypertension, unspecified	0.000	0.450	0.550
I15.8 Other secondary hypertension	0.000	0.450	0.550
I15.2 Hypertension secondary to endocrine disorders	0.000	0.450	0.550
I15.0 Renovascular hypertension	0.000	0.450	0.550
G96.0 Cerebrospinal fluid leak	0.550	0.450	0.000
G91.8 Other hydrocephalus	0.549	0.451	0.000
G91.3 Posttraumatic hydrocephalus, unspecified	0.549	0.451	0.000
G91.2 Normal-pressure hydrocephalus	0.549	0.451	0.000
G91.0 Communicating hydrocephalus	0.549	0.451	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.000	0.452	0.548
M07.3 Other psoriatic arthropathies	0.000	0.453	0.547
G83.1 Monoplegia of lower limb	0.546	0.454	0.000
E83.4 Disorders of magnesium metabolism	0.536	0.460	0.004
E88 Other metabolic disorders	0.002	0.460	0.538
G04.8 Other encephalitis, myelitis and encephalomyelitis	0.539	0.460	0.000
G04.2 Bacterial meningoencephalitis and meningomyelitis, not elsewhere classified	0.539	0.460	0.000
G04.1 Tropical spastic paraplegia	0.539	0.460	0.000
G04.0 Acute disseminated encephalitis	0.539	0.460	0.000
G06.1 Intraspinal abscess and granuloma	0.539	0.461	0.000
G82 Paraplegia and tetraplegia	0.536	0.464	0.000
G99.8 Other specified disorders of nervous system in diseases classified elsewhere	0.533	0.467	0.000
G99.1 Other disorders of autonomic nervous system in other diseases classified elsewhere	0.533	0.467	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.000	0.470	0.530
K90 Intestinal malabsorption	0.000	0.471	0.529
G06.0 Intracranial abscess and granuloma	0.528	0.472	0.000
G94.1 Hydrocephalus in neoplastic disease	0.528	0.472	0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.000	0.475	0.525
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.000	0.478	0.522
G83.8 Other specified paralytic syndromes	0.521	0.479	0.000
E06.3 Autoimmune thyroiditis	0.000	0.479	0.521
E05.8 Other thyrotoxicosis	0.000	0.484	0.516
E05.5 Thyroid crisis or storm	0.000	0.484	0.516
E05.4 Thyrotoxicosis factitia	0.000	0.484	0.516
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.484	0.516
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.484	0.516
G83.5 Locked-in syndrome	0.514	0.485	0.000
G83.3 Monoplegia, unspecified	0.514	0.485	0.000
G83.2 Monoplegia of upper limb	0.514	0.485	0.000
G83.0 Diplegia of upper limbs	0.514	0.485	0.000
G06.2 Extradural and subdural abscess, unspecified	0.514	0.485	0.000
E12.9 Without complications	0.000	0.486	0.514
E12.8 With unspecified complications	0.000	0.486	0.514
E12.7 With multiple complications	0.000	0.486	0.514
E12.6 With other specified complications	0.000	0.486	0.514
E12.5 With peripheral circulatory complications	0.000	0.486	0.514
E12.4 With neurological complications	0.000	0.486	0.514
E12.3 With ophthalmic complications	0.000	0.486	0.514
E12.2 With renal complications	0.000	0.486	0.514
E12.1 With ketoacidosis	0.000	0.486	0.514
E12.0 With coma	0.000	0.486	0.514
G36.9 Acute disseminated demyelination, unspecified	0.514	0.486	0.000
G36.8 Other specified acute disseminated demyelination	0.514	0.486	0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]	0.514	0.486	0.000
G36.0 Neuromyelitis optica [Devic]	0.514	0.486	0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.000	0.487	0.513
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.000	0.487	0.513
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.000	0.487	0.513
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.000	0.487	0.513
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.487	0.513
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.000	0.487	0.513
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.000	0.487	0.513
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.000	0.487	0.513
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.000	0.489	0.511
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.000	0.489	0.511
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.000	0.489	0.511
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.000	0.489	0.511
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.000	0.489	0.511
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.000	0.489	0.511
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.000	0.489	0.511
I23.8 Other current complications following acute myocardial infarction	0.000	0.491	0.509
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.001	0.492	0.507
E70.8 Other disorders of aromatic amino-acid metabolism	0.001	0.492	0.507
E70.3 Albinism	0.001	0.492	0.507
E70.2 Disorders of tyrosine metabolism	0.001	0.492	0.507
E70.1 Other hyperphenylalaninaemias	0.001	0.492	0.507
E70.0 Classical phenylketonuria	0.001	0.492	0.507
E71.3 Disorders of fatty-acid metabolism	0.001	0.492	0.507
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.001	0.492	0.507
E71.1 Other disorders of branched-chain amino-acid metabolism	0.001	0.492	0.507
E71.0 Maple-syrup-urine disease	0.001	0.492	0.507
E72.9 Disorder of amino-acid metabolism, unspecified	0.001	0.492	0.507
E72.8 Other specified disorders of amino-acid metabolism	0.001	0.492	0.507
E72.5 Disorders of glycine metabolism	0.001	0.492	0.507
E72.4 Disorders of ornithine metabolism	0.001	0.492	0.507
E72.3 Disorders of lysine and hydroxylysine metabolism	0.001	0.492	0.507
E72.2 Disorders of urea cycle metabolism	0.001	0.492	0.507
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.001	0.492	0.507
E72.0 Disorders of amino-acid transport	0.001	0.492	0.507
E74.9 Disorder of carbohydrate metabolism, unspecified	0.001	0.492	0.507
E74.8 Other specified disorders of carbohydrate metabolism	0.001	0.492	0.507
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.001	0.492	0.507
E74.3 Other disorders of intestinal carbohydrate absorption	0.001	0.492	0.507
E74.2 Disorders of galactose metabolism	0.001	0.492	0.507
E74.1 Disorders of fructose metabolism	0.001	0.492	0.507
E74.0 Glycogen storage disease	0.001	0.492	0.507
E75.6 Lipid storage disorder, unspecified	0.001	0.492	0.507
E75.5 Other lipid storage disorders	0.001	0.492	0.507
E75.4 Neuronal ceroid lipofuscinosis	0.001	0.492	0.507
E75.3 Sphingolipidosis, unspecified	0.001	0.492	0.507
E75.2 Other sphingolipidosis	0.001	0.492	0.507
E75.1 Other gangliosidosis	0.001	0.492	0.507
E75.0 GM2 gangliosidosis	0.001	0.492	0.507
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.001	0.492	0.507
E76.8 Other disorders of glucosaminoglycan metabolism	0.001	0.492	0.507
E76.3 Mucopolysaccharidosis, unspecified	0.001	0.492	0.507
E76.2 Other mucopolysaccharidoses	0.001	0.492	0.507
E76.1 Mucopolysaccharidosis, type II	0.001	0.492	0.507
E76.0 Mucopolysaccharidosis, type I	0.001	0.492	0.507
E77.9 Disorder of glycoprotein metabolism, unspecified	0.001	0.492	0.507
E77.8 Other disorders of glycoprotein metabolism	0.001	0.492	0.507
E77.1 Defects in glycoprotein degradation	0.001	0.492	0.507
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.001	0.492	0.507
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.001	0.492	0.507
E79.8 Other disorders of purine and pyrimidine metabolism	0.001	0.492	0.507
E79.1 Lesch-Nyhan syndrome	0.001	0.492	0.507
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.001	0.492	0.507
E84.9 Cystic fibrosis, unspecified	0.001	0.492	0.507
E84.8 Cystic fibrosis with other manifestations	0.001	0.492	0.507
E84.1 Cystic fibrosis with intestinal manifestations	0.001	0.492	0.507
E84.0 Cystic fibrosis with pulmonary manifestations	0.001	0.492	0.507
M06.0 Seronegative rheumatoid arthritis	0.000	0.492	0.508
G94.8 Other specified disorders of brain in diseases classified elsewhere	0.507	0.493	0.000
G94.2 Hydrocephalus in other diseases classified elsewhere	0.507	0.493	0.000
G94.0 Hydrocephalus in infectious and parasitic diseases classified elsewhere	0.507	0.493	0.000
G44.8 Other specified headache syndromes	0.505	0.495	0.000
G96.9 Disorder of central nervous system, unspecified	0.505	0.495	0.000
G96.8 Other specified disorders of central nervous system	0.505	0.495	0.000
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere	0.504	0.495	0.000
G14 Postpolio syndrome	0.504	0.495	0.000
G10 Huntington's disease	0.504	0.495	0.000
M05 Seropositive rheumatoid arthritis	0.000	0.496	0.504
G30.0 Alzheimer's disease with early onset	0.503	0.497	0.000
G46 Vascular syndromes of brain in cerebrovascular diseases	0.502	0.498	0.000
G40.8 Other epilepsy	0.501	0.499	0.000
M07.30 Other psoriatic arthropathies (Multiple sites)	0.000	0.500	0.500
M07.39 Other psoriatic arthropathies (Site unspecified)	0.000	0.503	0.497
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.001	0.503	0.496
E89.8 Other postprocedural endocrine and metabolic disorders	0.001	0.503	0.496
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.001	0.503	0.496
E89.5 Postprocedural testicular hypofunction	0.001	0.503	0.496
E89.4 Postprocedural ovarian failure	0.001	0.503	0.496
E89.1 Postprocedural hypoinsulinaemia	0.001	0.503	0.496
G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere	0.496	0.504	0.000
G32.0 Subacute combined degeneration of spinal cord in diseases classified elsewhere	0.496	0.504	0.000
G40.6 Grand mal seizures, unspecified (with or without petit mal)	0.493	0.507	0.000
G95 Other diseases of spinal cord	0.489	0.511	0.000
J40-J47 Chronic lower respiratory diseases	0.000	0.511	0.489
G02.8 Meningitis in other specified infectious and parasitic diseases classified elsewhere	0.488	0.511	0.000
G02.1 Meningitis in mycoses	0.488	0.511	0.000
G02.0 Meningitis in viral diseases classified elsewhere	0.488	0.511	0.000
G72 Other myopathies	0.488	0.512	0.000
I13.9 Hypertensive heart and renal disease, unspecified	0.000	0.512	0.487
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure	0.000	0.512	0.487
I13.1 Hypertensive heart and renal disease with renal failure	0.000	0.512	0.487
I13.0 Hypertensive heart and renal disease with (congestive) heart failure	0.000	0.512	0.487
O16 Unspecified maternal hypertension	0.000	0.513	0.487
G05.8 Encephalitis, myelitis and encephalomyelitis in other diseases classified elsewhere	0.486	0.514	0.000
G05.2 Encephalitis, myelitis and encephalomyelitis in other infectious and parasitic diseases classified elsewhere	0.486	0.514	0.000
G05.0 Encephalitis, myelitis and encephalomyelitis in bacterial diseases classified elsewhere	0.486	0.514	0.000
E44 Protein-energy malnutrition of moderate and mild degree	0.000	0.515	0.485
E45 Retarded development following protein-energy malnutrition	0.000	0.515	0.485
E43 Unspecified severe protein-energy malnutrition	0.000	0.515	0.485
E42 Marasmic kwashiorkor	0.000	0.515	0.485
E41 Nutritional marasmus	0.000	0.515	0.485
E40 Kwashiorkor	0.000	0.515	0.485
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.000	0.515	0.485
E06.5 Other chronic thyroiditis	0.000	0.516	0.483
E06.4 Drug-induced thyroiditis	0.000	0.516	0.483
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.000	0.516	0.483
E06.1 Subacute thyroiditis	0.000	0.516	0.483
E06.0 Acute thyroiditis	0.000	0.516	0.483
Chapter XV Pregnancy, childbirth and the puerperium	0.000	0.517	0.483
G05.1 Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere	0.482	0.518	0.000
I21.0 Acute transmural myocardial infarction of anterior wall	0.000	0.518	0.482
G21.9 Secondary Parkinsonism, unspecified	0.482	0.518	0.000
G21.8 Other secondary Parkinsonism	0.482	0.518	0.000
G21.4 Vascular parkinsonism	0.482	0.518	0.000
G21.3 Postencephalitic Parkinsonism	0.482	0.518	0.000
G21.2 Secondary Parkinsonism due to other external agents	0.482	0.518	0.000
G21.1 Other drug-induced secondary Parkinsonism	0.482	0.518	0.000
G21.0 Malignant neuroleptic syndrome	0.482	0.518	0.000
G23.9 Degenerative disease of basal ganglia, unspecified	0.482	0.518	0.000
G23.8 Other specified degenerative diseases of basal ganglia	0.482	0.518	0.000
G23.3 Multiple system atrophy, cerebellar type	0.482	0.518	0.000
G23.2 Striatonigral degeneration	0.482	0.518	0.000
G23.1 Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]	0.482	0.518	0.000
G23.0 Hallervorden-Spatz disease	0.482	0.518	0.000
L41.9 Parapsoriasis, unspecified	0.000	0.520	0.479
L41.8 Other parapsoriasis	0.000	0.520	0.479
L41.5 Retiform parapsoriasis	0.000	0.520	0.479
L41.4 Large plaque parapsoriasis	0.000	0.520	0.479
L41.3 Small plaque parapsoriasis	0.000	0.520	0.479
L41.2 Lymphomatoid papulosis	0.000	0.520	0.479
L41.1 Pityriasis lichenoides chronica	0.000	0.520	0.479
L41.0 Pityriasis lichenoides et varioliformis acuta	0.000	0.520	0.479
L44.9 Papulosquamous disorder, unspecified	0.000	0.520	0.479
L44.8 Other specified papulosquamous disorders	0.000	0.520	0.479
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]	0.000	0.520	0.479
L44.3 Lichen ruber moniliformis	0.000	0.520	0.479
L44.2 Lichen striatus	0.000	0.520	0.479
L44.1 Lichen nitidus	0.000	0.520	0.479
L44.0 Pityriasis rubra pilaris	0.000	0.520	0.479
E05.9 Thyrotoxicosis, unspecified	0.000	0.521	0.479
G91.9 Hydrocephalus, unspecified	0.478	0.522	0.000
E80.7 Disorder of bilirubin metabolism, unspecified	0.001	0.523	0.476
E80.6 Other disorders of bilirubin metabolism	0.001	0.523	0.476
E80.5 Crigler-Najjar syndrome	0.001	0.523	0.476
E80.3 Defects of catalase and peroxydase	0.001	0.523	0.476
E80.2 Other porphyria	0.001	0.523	0.476
E80.1 Porphyria cutanea tarda	0.001	0.523	0.476
E80.0 Hereditary erythropoietic porphyria	0.001	0.523	0.476
G73 Disorders of myoneural junction and muscle in diseases classified elsewhere	0.475	0.525	0.000
Chapter X Diseases of the respiratory system	0.000	0.526	0.474
E89.2 Postprocedural hypoparathyroidism	0.001	0.526	0.473
G30.8 Other Alzheimer's disease	0.471	0.529	0.000
G30.1 Alzheimer's disease with late onset	0.471	0.529	0.000
G40.5 Special epileptic syndromes	0.471	0.529	0.000
G44.0 Cluster headache syndrome	0.469	0.531	0.000
G96.1 Disorders of meninges, not elsewhere classified	0.468	0.531	0.000
E85.8 Other amyloidosis	0.001	0.534	0.465
E85.3 Secondary systemic amyloidosis	0.001	0.534	0.465
E85.2 Heredofamilial amyloidosis, unspecified	0.001	0.534	0.465
E85.1 Neuropathic heredofamilial amyloidosis	0.001	0.534	0.465

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations