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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3135344
log Bayes Factor = 280.03
Chromosome 6   position 32,395,036  (GRCh37) Explore rs3135344 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
E16.2 Hypoglycaemia, unspecified
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
J45.9 Asthma, unspecified
0.000 0.000 1.000
K51.9 Ulcerative colitis, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
K51 Ulcerative colitis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
J33 Nasal polyp
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
C44.3 Skin of other and unspecified parts of face
1.000 0.000 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
J33.9 Nasal polyp, unspecified
0.000 0.000 1.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.000 1.000
J33.0 Polyp of nasal cavity
0.000 0.000 1.000
E10.4 With neurological complications
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
Z93.2 Ileostomy status
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E14.9 Without complications
0.000 0.001 0.999
M06.9 Rheumatoid arthritis, unspecified
0.000 0.001 0.999
L40.9 Psoriasis, unspecified
0.998 0.002 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.002 0.998
L40.5 Arthropathic psoriasis
0.998 0.002 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.002 0.998
L40 Psoriasis
0.997 0.003 0.000
E14.3 With ophthalmic complications
0.000 0.003 0.997
C44 Other malignant neoplasms of skin
0.992 0.008 0.000
E11.9 Without complications
0.000 0.009 0.991
H36 Retinal disorders in diseases classified elsewhere
0.000 0.009 0.991
K51.4 Pseudopolyposis of colon
0.990 0.010 0.000
K51.3 Ulcerative (chronic) rectosigmoiditis
0.988 0.012 0.000
K51.8 Other ulcerative colitis
0.987 0.013 0.000
H30-H36 Disorders of choroid and retina
0.000 0.015 0.985
K51.2 Ulcerative (chronic) proctitis
0.984 0.016 0.000
K90 Intestinal malabsorption
0.000 0.018 0.982
M06 Other rheumatoid arthritis
0.000 0.021 0.979
E10.5 With peripheral circulatory complications
0.000 0.024 0.976
J33.8 Other polyp of sinus
0.000 0.025 0.975
C44.7 Skin of lower limb, including hip
0.974 0.026 0.000
J45 Asthma
0.000 0.027 0.973
Chapter VII Diseases of the eye and adnexa
0.000 0.028 0.972
# Top node
0.000 0.028 0.972
M05-M14 Inflammatory polyarthropathies
0.000 0.029 0.971
M05 Seropositive rheumatoid arthritis
0.000 0.031 0.969
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.033 0.967
H43-H45 Disorders of vitreous body and globe
0.000 0.036 0.964
G35-G37 Demyelinating diseases of the central nervous system
0.963 0.037 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.037 0.963
E11.1 With ketoacidosis
0.000 0.037 0.963
H43 Disorders of vitreous body
0.000 0.038 0.962
E10.2 With renal complications
0.000 0.044 0.956
G37 Other demyelinating diseases of central nervous system
0.956 0.044 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.047 0.953
J40-J47 Chronic lower respiratory diseases
0.000 0.049 0.951
Chapter X Diseases of the respiratory system
0.000 0.049 0.951
G37.9 Demyelinating disease of central nervous system, unspecified
0.950 0.050 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.050 0.950
E10.8 With unspecified complications
0.000 0.050 0.950
D64.9 Anaemia, unspecified
0.000 0.052 0.948
D60-D64 Aplastic and other anaemias
0.000 0.053 0.947
D64 Other anaemias
0.000 0.053 0.947
H35 Other retinal disorders
0.000 0.054 0.946
K90.9 Intestinal malabsorption, unspecified
0.000 0.062 0.938
H43.8 Other disorders of vitreous body
0.000 0.063 0.937
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.065 0.935
Chapter VIII Diseases of the ear and mastoid process
0.000 0.065 0.935
H60-H62 Diseases of external ear
0.000 0.065 0.935
D50-D53 Nutritional anaemias
0.000 0.065 0.935
J30-J39 Other diseases of upper respiratory tract
0.000 0.066 0.934
H61 Other disorders of external ear
0.000 0.067 0.933
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.068 0.932
E10.0 With coma
0.000 0.069 0.931
H43.3 Other vitreous opacities
0.000 0.070 0.930
D50.9 Iron deficiency anaemia, unspecified
0.000 0.073 0.927
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.074 0.926
D50 Iron deficiency anaemia
0.000 0.074 0.926
C44.4 Skin of scalp and neck
0.925 0.075 0.000
H61.0 Perichondritis of external ear
0.000 0.076 0.924
C44.9 Malignant neoplasm of skin, unspecified
0.923 0.077 0.000
M35.3 Polymyalgia rheumatica
0.000 0.078 0.922
M35 Other systemic involvement of connective tissue
0.000 0.080 0.920
M20-M25 Other joint disorders
0.000 0.080 0.920
K90-K93 Other diseases of the digestive system
0.000 0.086 0.914
E11.5 With peripheral circulatory complications
0.000 0.088 0.912
Chapter XI Diseases of the digestive system
0.000 0.090 0.910
D80-D89 Certain disorders involving the immune mechanism
0.000 0.091 0.909
E07 Other disorders of thyroid
0.000 0.092 0.908
E06 Thyroiditis
0.000 0.094 0.906
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.094 0.906
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.095 0.905
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.096 0.904
E11.3 With ophthalmic complications
0.000 0.096 0.904
E13 Other specified diabetes mellitus
0.000 0.104 0.896
D86 Sarcoidosis
0.000 0.108 0.892
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.113 0.887
J46 Status asthmaticus
0.000 0.114 0.886
M23 Internal derangement of knee
0.000 0.115 0.885
M23.3 Other meniscus derangements
0.000 0.116 0.884
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.000 0.117 0.883
K70-K77 Diseases of liver
0.000 0.118 0.882
K51.5 Mucosal proctocolitis
0.881 0.119 0.000
H34 Retinal vascular occlusions
0.000 0.131 0.869
H35.8 Other specified retinal disorders
0.000 0.131 0.869
D86.9 Sarcoidosis, unspecified
0.000 0.132 0.868
E03.8 Other specified hypothyroidism
0.000 0.139 0.861
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.144 0.856
K86 Other diseases of pancreas
0.000 0.145 0.855
E07.9 Disorder of thyroid, unspecified
0.000 0.147 0.853
E10.6 With other specified complications
0.000 0.147 0.853
E06.3 Autoimmune thyroiditis
0.000 0.148 0.852
H61.3 Acquired stenosis of external ear canal
0.000 0.148 0.852
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.000 0.148 0.852
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.000 0.153 0.847
H35.5 Hereditary retinal dystrophy
0.000 0.155 0.845
M06.4 Inflammatory polyarthropathy
0.000 0.155 0.845
K86.0 Alcohol-induced chronic pancreatitis
0.000 0.157 0.843
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.000 0.158 0.842
E14.1 With ketoacidosis
0.000 0.161 0.839
K75 Other inflammatory liver diseases
0.000 0.163 0.837
C44.2 Skin of ear and external auricular canal
0.833 0.167 0.000
K86.1 Other chronic pancreatitis
0.000 0.167 0.833
H35.0 Background retinopathy and retinal vascular changes
0.000 0.168 0.832
E11.6 With other specified complications
0.000 0.168 0.832
K75.4 Autoimmune hepatitis
0.000 0.169 0.831
H43.1 Vitreous haemorrhage
0.000 0.173 0.827
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.175 0.825
J86 Pyothorax
0.000 0.178 0.822
E13.9 Without complications
0.000 0.181 0.819
H35.4 Peripheral retinal degeneration
0.000 0.182 0.818
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.000 0.184 0.816
E14.6 With other specified complications
0.000 0.186 0.813
H60 Otitis externa
0.000 0.188 0.812
E16.1 Other hypoglycaemia
0.000 0.189 0.811
H61.8 Other specified disorders of external ear
0.000 0.192 0.808
M23.5 Chronic instability of knee
0.000 0.194 0.806
E14.8 With unspecified complications
0.000 0.196 0.804
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.197 0.803
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)
0.000 0.198 0.802
H35.2 Other proliferative retinopathy
0.000 0.199 0.801
J37 Chronic laryngitis and laryngotracheitis
0.000 0.203 0.797
K74 Fibrosis and cirrhosis of liver
0.000 0.206 0.794
E14.2 Withrenal complications
0.000 0.209 0.791
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.210 0.790
E11.2 With renal complications
0.000 0.215 0.785
J45.0 Predominantly allergic asthma
0.000 0.216 0.784
J33.1 Polypoid sinus degeneration
0.000 0.222 0.778
H34.8 Other retinal vascular occlusions
0.000 0.223 0.777
Q60-Q64 Congenital malformations of the urinary system
0.000 0.230 0.770
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.000 0.232 0.768
D86.8 Sarcoidosis of other and combined sites
0.000 0.233 0.767
M35.1 Other overlap syndromes
0.000 0.238 0.762
K73 Chronic hepatitis, not elsewhere classified
0.000 0.238 0.762
E05.8 Other thyrotoxicosis
0.000 0.240 0.760
Q80-Q89 Other congenital malformations
0.000 0.241 0.759
H53-H54 Visual disturbances and blindness
0.000 0.247 0.753
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.250 0.750
J42 Unspecified chronic bronchitis
0.000 0.253 0.747
M12 Other specific arthropathies
0.000 0.253 0.747
M23.30 Other meniscus derangements (Multiple sites)
0.000 0.253 0.747
M35.7 Hypermobility syndrome
0.000 0.253 0.747
J86.0 Pyothorax with fistula
0.000 0.254 0.746
K86.3 Pseudocyst of pancreas
0.000 0.257 0.743
Q38-Q45 Other congenital malformations of the digestive system
0.000 0.261 0.739
M86-M90 Other osteopathies
0.000 0.263 0.737
E40-E46 Malnutrition
0.000 0.264 0.736
M23.0 Cystic meniscus
0.000 0.267 0.733
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.267 0.733
Q61 Cystic kidney disease
0.000 0.268 0.732
K82 Other diseases of gallbladder
0.000 0.272 0.728
Q85 Phakomatoses, not elsewhere classified
0.000 0.273 0.727
H35.6 Retinal haemorrhage
0.000 0.275 0.725
K72 Hepatic failure, not elsewhere classified
0.000 0.278 0.722
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.283 0.717
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.283 0.717
E16.4 Abnormal secretion of gastrin
0.000 0.283 0.717
E16.3 Increased secretion of glucagon
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.715 0.285 0.000
L40.2 Acrodermatitis continua
0.715 0.285 0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.714 0.286 0.000
M32 Systemic lupus erythematosus
0.000 0.286 0.714
E14.5 With peripheral circulatory complications
0.000 0.287 0.713
C44.8 Overlapping lesion of skin
0.711 0.289 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.289 0.711
J45.1 Nonallergic asthma
0.000 0.291 0.709
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.294 0.706
H54 Blindness and low vision
0.000 0.295 0.705
K90.3 Pancreatic steatorrhoea
0.000 0.296 0.704
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.296 0.704
K90.1 Tropical sprue
0.000 0.296 0.704
K74.3 Primary biliary cirrhosis
0.000 0.296 0.704
H60.3 Other infective otitis externa
0.000 0.298 0.702
H61.1 Non-infective disorders of pinna
0.000 0.298 0.702
M06.2 Rheumatoid bursitis
0.000 0.298 0.702
M06.1 Adult-onset Still's disease
0.000 0.298 0.702
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.000 0.300 0.700
J37.0 Chronic laryngitis
0.000 0.301 0.699
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.302 0.698
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.303 0.697
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.303 0.696
M08 Juvenile arthritis
0.000 0.303 0.696
H43.2 Crystalline deposits in vitreous body
0.000 0.305 0.695
G36 Other acute disseminated demyelination
0.694 0.305 0.000
M05.8 Other seropositive rheumatoid arthritis
0.000 0.306 0.694
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.306 0.694
M05.1 Rheumatoid lung disease
0.000 0.306 0.694
M05.0 Felty's syndrome
0.000 0.306 0.694
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.307 0.693
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.307 0.693
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.307 0.693
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.307 0.693
M05.2 Rheumatoid vasculitis
0.000 0.307 0.693
D83 Common variable immunodeficiency
0.000 0.309 0.691
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.309 0.691
H43.0 Vitreous prolapse
0.000 0.310 0.690
H60.8 Other otitis externa
0.000 0.310 0.690
J86.9 Pyothorax without fistula
0.000 0.311 0.689
D80 Immunodeficiency with predominantly antibody defects
0.000 0.313 0.687
G37.5 Concentric sclerosis [Balo]
0.685 0.314 0.000
G37.4 Subacute necrotising myelitis
0.685 0.314 0.000
G37.2 Central pontine myelinolysis
0.685 0.314 0.000
G37.1 Central demyelination of corpus callosum
0.685 0.314 0.000
G37.0 Diffuse sclerosis
0.685 0.314 0.000
J85 Abscess of lung and mediastinum
0.000 0.315 0.685
M33 Dermatopolymyositis
0.000 0.316 0.684
G37.8 Other specified demyelinating diseases of central nervous system
0.683 0.317 0.000
H43.9 Disorder of vitreous body, unspecified
0.000 0.319 0.681
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.320 0.680
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.321 0.679
D64.4 Congenital dyserythropoietic anaemia
0.000 0.321 0.679
D64.3 Other sideroblastic anaemias
0.000 0.321 0.679
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.321 0.679
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.321 0.679
D64.0 Hereditary sideroblastic anaemia
0.000 0.321 0.679
H35.1 Retinopathy of prematurity
0.000 0.321 0.678
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.678 0.322 0.000
H54.7 Unspecified visual loss
0.000 0.324 0.676
D86.3 Sarcoidosis of skin
0.000 0.324 0.676
L40-L45 Papulosquamous disorders
0.625 0.326 0.049
M06.8 Other specified rheumatoid arthritis
0.000 0.326 0.674
H60.9 Otitis externa, unspecified
0.000 0.326 0.674
K74.5 Biliary cirrhosis, unspecified
0.000 0.328 0.672
M14 Arthropathies in other diseases classified elsewhere
0.000 0.328 0.672
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)
0.000 0.329 0.671
H62 Disorders of external ear in diseases classified elsewhere
0.000 0.331 0.669
C44.1 Skin of eyelid, including canthus
0.669 0.331 0.000
Q61.3 Polycystic kidney, unspecified
0.000 0.334 0.666
M35.2 Behcet's disease
0.000 0.334 0.666
Q44.6 Cystic disease of liver
0.000 0.334 0.666
H34.2 Other retinal artery occlusions
0.000 0.334 0.666
Q61.2 Polycystic kidney, adult type
0.000 0.335 0.665
D50.1 Sideropenic dysphagia
0.000 0.336 0.664
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.000 0.337 0.663
L40.3 Pustulosis palmaris et plantaris
0.662 0.337 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.000 0.338 0.662
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.339 0.661
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.340 0.660
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.340 0.660
M35.5 Multifocal fibrosclerosis
0.000 0.340 0.660
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.340 0.660
K72.0 Acute and subacute hepatic failure
0.000 0.343 0.657
D53 Other nutritional anaemias
0.000 0.343 0.657
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.344 0.656
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.345 0.655
K90.8 Other intestinal malabsorption
0.000 0.345 0.655
K74.6 Other and unspecified cirrhosis of liver
0.000 0.346 0.654
E03.1 Congenital hypothyroidism without goitre
0.000 0.347 0.653
D81 Combined immunodeficiencies
0.000 0.348 0.652
E07.1 Dyshormogenetic goitre
0.000 0.349 0.651
E07.0 Hypersecretion of calcitonin
0.000 0.349 0.651
M30 Polyarteritis nodosa and related conditions
0.000 0.350 0.650
Q85.9 Phakomatosis, unspecified
0.000 0.350 0.650
E13.3 With ophthalmic complications
0.000 0.350 0.650
D86.1 Sarcoidosis of lymph nodes
0.000 0.350 0.650
E06.5 Other chronic thyroiditis
0.000 0.350 0.649
E06.4 Drug-induced thyroiditis
0.000 0.350 0.649
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.350 0.649
E06.1 Subacute thyroiditis
0.000 0.350 0.649
E06.0 Acute thyroiditis
0.000 0.350 0.649
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.352 0.647
M21 Other acquired deformities of limbs
0.000 0.353 0.647
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.353 0.647
L40.1 Generalised pustular psoriasis
0.645 0.355 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.000 0.355 0.645
M23.03 Cystic meniscus (Medial collateral ligament or Other and unspecified medial meniscus)
0.000 0.355 0.645
E14.4 With neurological complications
0.000 0.355 0.645
L40.8 Other psoriasis
0.642 0.357 0.000
E13.8 With unspecified complications
0.000 0.358 0.642
E13.7 With multiple complications
0.000 0.358 0.642
E13.6 With other specified complications
0.000 0.358 0.642
E13.5 With peripheral circulatory complications
0.000 0.358 0.642
E13.4 With neurological complications
0.000 0.358 0.642
E13.2 With renal complications
0.000 0.358 0.642
E13.1 With ketoacidosis
0.000 0.358 0.642
E13.0 With coma
0.000 0.358 0.642
K71 Toxic liver disease
0.000 0.359 0.641
Q85.0 Neurofibromatosis (nonmalignant)
0.000 0.360 0.640
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.360 0.640
K82.8 Other specified diseases of gallbladder
0.000 0.361 0.639
Q89 Other congenital malformations, not elsewhere classified
0.000 0.362 0.638
D82 Immunodeficiency associated with other major defects
0.000 0.362 0.638
E11.8 With unspecified complications
0.000 0.363 0.637
J95-J99 Other diseases of the respiratory system
0.000 0.364 0.636
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.000 0.364 0.636
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.000 0.364 0.636
K51.0 Ulcerative (chronic) enterocolitis
0.635 0.365 0.000
M23.37 Other meniscus derangements-Capsular lig
0.000 0.366 0.634
H61.9 Disorder of external ear, unspecified
0.000 0.367 0.633
K77 Liver disorders in diseases classified elsewhere
0.000 0.367 0.632
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.369 0.631
K73.2 Chronic active hepatitis, not elsewhere classified
0.000 0.369 0.631
K86.2 Cyst of pancreas
0.000 0.369 0.631
H34.1 Central retinal artery occlusion
0.000 0.369 0.630
M22 Disorders of patella
0.000 0.371 0.629
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.374 0.626
K75.3 Granulomatous hepatitis, not elsewhere classified
0.000 0.376 0.623
H34.0 Transient retinal artery occlusion
0.000 0.377 0.623
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.623 0.377 0.000
M12.3 Palindromic rheumatism
0.000 0.380 0.620
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.380 0.620
H54.0 Blindness, both eyes
0.000 0.382 0.618
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
0.000 0.383 0.617
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.384 0.616
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.000 0.386 0.614
K51.1 Ulcerative (chronic) ileocolitis
0.614 0.386 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.000 0.388 0.612
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere
0.000 0.389 0.611
K73.8 Other chronic hepatitis, not elsewhere classified
0.000 0.391 0.609
C44.0 Skin of lip
0.607 0.393 0.000
J41 Simple and mucopurulent chronic bronchitis
0.000 0.394 0.606
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.394 0.606
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.394 0.606
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.394 0.606
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.394 0.606
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.394 0.606
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.394 0.606
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.394 0.606
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.394 0.606
Q35-Q37 Cleft lip and cleft palate
0.000 0.397 0.602
K75.2 Nonspecific reactive hepatitis
0.000 0.400 0.600
K75.1 Phlebitis of portal vein
0.000 0.400 0.600
J43 Emphysema
0.000 0.400 0.600
E07.8 Other specified disorders of thyroid
0.000 0.401 0.599
K82.9 Disease of gallbladder, unspecified
0.000 0.403 0.597
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter
0.000 0.404 0.596
H06.2 Dysthyroid exophthalmos
0.000 0.405 0.595
H34.9 Retinal vascular occlusion, unspecified
0.000 0.405 0.595
D64.8 Other specified anaemias
0.000 0.406 0.593
D51 Vitamin B12 deficiency anaemia
0.000 0.407 0.593
C44.5 Skin of trunk
0.592 0.408 0.000
J85.2 Abscess of lung without pneumonia
0.000 0.408 0.592
M06.3 Rheumatoid nodule
0.000 0.408 0.592
M86 Osteomyelitis
0.000 0.408 0.592
M35.8 Other specified systemic involvement of connective tissue
0.000 0.410 0.589
M60-M63 Disorders of muscles
0.000 0.412 0.588
M88 Paget's disease of bone [osteitis deformans]
0.000 0.412 0.588
Q60 Renal agenesis and other reduction defects of kidney
0.000 0.414 0.586
D63 Anaemia in chronic diseases classified elsewhere
0.000 0.415 0.585
L42 Pityriasis rosea
0.564 0.416 0.020
E06.9 Thyroiditis, unspecified
0.000 0.416 0.583
J45.8 Mixed asthma
0.000 0.417 0.583
C82.0 Small cleaved cell, follicular
0.583 0.417 0.000
H30 Chorioretinal inflammation
0.000 0.418 0.582
H60.2 Malignant otitis externa
0.000 0.418 0.582
Q61.0 Congenital single renal cyst
0.000 0.420 0.580
H60.4 Cholesteatoma of external ear
0.000 0.421 0.579
M23.57 Chronic instability of knee (Capsular ligament)
0.000 0.422 0.578
M23.56 Chronic instability of knee (Other and unspecified lateral meniscus)
0.000 0.422 0.578
M23.55 Chronic instability of knee (Posterior horn of lateral meniscus)
0.000 0.422 0.578
M23.54 Chronic instability of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.000 0.422 0.578
M23.53 Chronic instability of knee (Medial collateral ligament or Other and unspecified medial meniscus)
0.000 0.422 0.578
M23.52 Chronic instability of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.000 0.422 0.578
M23.50 Chronic instability of knee (Multiple sites)
0.000 0.422 0.578
K50-K52 Noninfective enteritis and colitis
0.486 0.423 0.091
Q38 Other congenital malformations of tongue, mouth and pharynx
0.000 0.424 0.576
Q85.8 Other phakomatoses, not elsewhere classified
0.000 0.425 0.575
M23.1 Discoid meniscus (congenital)
0.000 0.425 0.575
H25-H28 Disorders of lens
0.000 0.426 0.574
J37.1 Chronic laryngotracheitis
0.000 0.428 0.571
K74.4 Secondary biliary cirrhosis
0.000 0.430 0.569
K74.2 Hepatic fibrosis with hepatic sclerosis
0.000 0.430 0.569
M34 Systemic sclerosis
0.000 0.437 0.563
K73.9 Chronic hepatitis, unspecified
0.000 0.437 0.563
M23.09 Cystic meniscus (Unspecified ligament or Unspecified meniscus)
0.000 0.438 0.562
M90 Osteopathies in diseases classified elsewhere
0.000 0.439 0.561
E11.0 With coma
0.000 0.439 0.561
H60.5 Acute otitis externa, non-infective
0.000 0.441 0.559
M32.1 Systemic lupus erythematosus with organ or system involvement
0.000 0.445 0.555
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified
0.000 0.445 0.554
D86.0 Sarcoidosis of lung
0.000 0.446 0.554
Q78 Other osteochondrodysplasias
0.000 0.446 0.554
K82.2 Perforation of gallbladder
0.000 0.446 0.554
J99 Respiratory disorders in diseases classified elsewhere
0.000 0.446 0.553
H61.2 Impacted cerumen
0.000 0.447 0.553
K70 Alcoholic liver disease
0.000 0.448 0.552
Q89.2 Congenital malformations of other endocrine glands
0.000 0.448 0.552
M21.0 Valgus deformity, not elsewhere classified
0.000 0.450 0.550
K86.8 Other specified diseases of pancreas
0.000 0.451 0.548
E46 Unspecified protein-energy malnutrition
0.000 0.453 0.547
K73.1 Chronic lobular hepatitis, not elsewhere classified
0.000 0.454 0.546
K73.0 Chronic persistent hepatitis, not elsewhere classified
0.000 0.454 0.546
Q86 Congenital malformation syndromes due to known exogenous causes, not elsewhere classified
0.000 0.455 0.544
Q84 Other congenital malformations of integument
0.000 0.455 0.544
Q81 Epidermolysis bullosa
0.000 0.455 0.544
Q80 Congenital ichthyosis
0.000 0.455 0.544
M21.2 Flexion deformity
0.000 0.456 0.544
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot
0.000 0.459 0.541
H54.2 Low vision, both eyes
0.000 0.459 0.541
E65-E68 Obesity and other hyperalimentation
0.000 0.459 0.541
Q30-Q34 Congenital malformations of the respiratory system
0.000 0.460 0.540
Q44.5 Other congenital malformations of bile ducts
0.000 0.462 0.538
M23.9 Internal derangement of knee, unspecified
0.000 0.463 0.536
D83.9 Common variable immunodeficiency, unspecified
0.000 0.464 0.536
L41 Parapsoriasis
0.505 0.464 0.031
M12.5 Traumatic arthropathy
0.000 0.464 0.535
M12.4 Intermittent hydrarthrosis
0.000 0.464 0.535
M12.1 Kaschin-Beck disease
0.000 0.464 0.535
M12.0 Chronic postrheumatic arthropathy [Jaccoud]
0.000 0.464 0.535
Q39 Congenital malformations of oesophagus
0.000 0.465 0.535
K82.0 Obstruction of gallbladder
0.000 0.465 0.535
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.465 0.535
Q65 Congenital deformities of hip
0.000 0.466 0.534
M33.2 Polymyositis
0.000 0.470 0.530
Q42 Congenital absence, atresia and stenosis of large intestine
0.000 0.470 0.530
Q41 Congenital absence, atresia and stenosis of small intestine
0.000 0.470 0.530
K82.1 Hydrops of gallbladder
0.000 0.470 0.530
M30.0 Polyarteritis nodosa
0.000 0.471 0.529
M11 Other crystal arthropathies
0.000 0.471 0.529
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.472 0.528
E45 Retarded development following protein-energy malnutrition
0.000 0.472 0.528
E43 Unspecified severe protein-energy malnutrition
0.000 0.472 0.528
E42 Marasmic kwashiorkor
0.000 0.472 0.528
E41 Nutritional marasmus
0.000 0.472 0.528
E40 Kwashiorkor
0.000 0.472 0.528
M31 Other necrotising vasculopathies
0.000 0.472 0.528
M32.8 Other forms of systemic lupus erythematosus
0.000 0.474 0.526
M23.07 Cystic meniscus-Capsular lig
0.000 0.474 0.526
M23.05 Cystic meniscus (Posterior horn of lateral meniscus)
0.000 0.474 0.526
M23.02 Cystic meniscus (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.000 0.474 0.526
M23.01 Cystic meniscus (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.000 0.474 0.526
M23.00 Cystic meniscus (Multiple sites)
0.000 0.474 0.526
D52 Folate deficiency anaemia
0.000 0.474 0.525
Q61.8 Other cystic kidney diseases
0.000 0.475 0.525
Q61.1 Polycystic kidney, infantile type
0.000 0.475 0.525
K74.0 Hepatic fibrosis
0.000 0.475 0.525
K82.3 Fistula of gallbladder
0.000 0.475 0.525
H54.1 Blindness, one eye, low vision, other eye
0.000 0.475 0.525
E83 Disorders of mineral metabolism
0.523 0.477 0.000
Q43 Other congenital malformations of intestine
0.000 0.477 0.523
M10 Gout
0.000 0.477 0.523
L40.0 Psoriasis vulgaris
0.522 0.477 0.000
Q85.1 Tuberous sclerosis
0.000 0.479 0.521
M12.8 Other specific arthropathies, not elsewhere classified
0.000 0.480 0.520
Q83 Congenital malformations of breast
0.000 0.482 0.518
H31 Other disorders of choroid
0.000 0.483 0.517
M22.9 Disorder of patella, unspecified
0.000 0.483 0.517
K72.1 Chronic hepatic failure
0.000 0.485 0.515
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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