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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3135377
log Bayes Factor = 230.633
Chromosome 6   position 32,385,399  (GRCh37) Explore rs3135377 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
E16.2 Hypoglycaemia, unspecified
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
L40 Psoriasis
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
I10-I15 Hypertensive diseases
0.000 0.000 1.000
L40-L45 Papulosquamous disorders
0.000 0.000 1.000
Chapter IX Diseases of the circulatory system
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E10.4 With neurological complications
0.000 0.000 1.000
I10 Essential (primary) hypertension
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.000 1.000
E16 Other disorders of pancreatic internal secretion
0.000 0.000 1.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E14.9 Without complications
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
E11.3 With ophthalmic complications
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
J33.9 Nasal polyp, unspecified
0.000 0.001 0.999
M35.3 Polymyalgia rheumatica
0.000 0.001 0.999
J33 Nasal polyp
0.000 0.001 0.999
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.001 0.999
E78.0 Pure hypercholesterolaemia
0.000 0.001 0.999
I22 Subsequent myocardial infarction
0.000 0.001 0.999
E14.3 With ophthalmic complications
0.000 0.001 0.999
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.002 0.998
E10.5 With peripheral circulatory complications
0.000 0.002 0.998
G35-G37 Demyelinating diseases of the central nervous system
0.997 0.002 0.001
E70-E90 Metabolic disorders
0.000 0.002 0.998
L40.9 Psoriasis, unspecified
0.000 0.003 0.997
H36 Retinal disorders in diseases classified elsewhere
0.000 0.003 0.997
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.003 0.997
G37 Other demyelinating diseases of central nervous system
0.996 0.004 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.004 0.996
G37.9 Demyelinating disease of central nervous system, unspecified
0.995 0.005 0.000
J33.0 Polyp of nasal cavity
0.000 0.005 0.995
H30-H36 Disorders of choroid and retina
0.000 0.005 0.995
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.005 0.995
M35 Other systemic involvement of connective tissue
0.000 0.006 0.994
L43 Lichen planus
0.000 0.008 0.992
Chapter VII Diseases of the eye and adnexa
0.000 0.008 0.992
J33.8 Other polyp of sinus
0.000 0.009 0.991
M20-M25 Other joint disorders
0.000 0.010 0.990
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.011 0.989
M07 Psoriatic and enteropathic arthropathies
0.000 0.012 0.988
E11.1 With ketoacidosis
0.000 0.014 0.986
I12 Hypertensive renal disease
0.000 0.014 0.986
E06 Thyroiditis
0.000 0.017 0.983
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.017 0.983
M07.3 Other psoriatic arthropathies
0.000 0.019 0.981
L43.9 Lichen planus, unspecified
0.000 0.019 0.981
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.021 0.979
E10.2 With renal complications
0.000 0.023 0.977
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.024 0.976
E06.3 Autoimmune thyroiditis
0.000 0.028 0.972
I20 Angina pectoris
0.000 0.028 0.972
I12.9 Hypertensive renal disease without renal failure
0.000 0.029 0.971
Chapter VIII Diseases of the ear and mastoid process
0.000 0.030 0.970
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.036 0.964
H60-H62 Diseases of external ear
0.000 0.039 0.961
M06.0 Seronegative rheumatoid arthritis
0.000 0.047 0.953
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.053 0.947
H61 Other disorders of external ear
0.000 0.057 0.943
M45-M49 Spondylopathies
0.000 0.063 0.937
M45 Ankylosing spondylitis
0.000 0.064 0.936
M06.3 Rheumatoid nodule
0.000 0.067 0.933
E10.8 With unspecified complications
0.000 0.068 0.932
H35 Other retinal disorders
0.000 0.072 0.928
M65-M68 Disorders of synovium and tendon
0.000 0.073 0.927
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.075 0.925
I20.9 Angina pectoris, unspecified
0.000 0.077 0.923
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.080 0.920
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.081 0.919
E78.2 Mixed hyperlipidaemia
0.000 0.081 0.919
H40-H42 Glaucoma
0.000 0.081 0.919
H35.8 Other specified retinal disorders
0.000 0.084 0.916
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.091 0.909
I20.0 Unstable angina
0.000 0.091 0.909
E11.5 With peripheral circulatory complications
0.000 0.094 0.906
H43-H45 Disorders of vitreous body and globe
0.000 0.094 0.906
H61.0 Perichondritis of external ear
0.000 0.095 0.905
M34 Systemic sclerosis
0.000 0.098 0.902
M65 Synovitis and tenosynovitis
0.000 0.099 0.901
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.103 0.897
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.103 0.897
M06.4 Inflammatory polyarthropathy
0.000 0.113 0.887
E11.2 With renal complications
0.000 0.116 0.884
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.117 0.883
H43 Disorders of vitreous body
0.000 0.119 0.881
E89.0 Postprocedural hypothyroidism
0.000 0.126 0.874
M31 Other necrotising vasculopathies
0.000 0.126 0.874
E07 Other disorders of thyroid
0.000 0.131 0.869
H35.4 Peripheral retinal degeneration
0.000 0.132 0.868
H40 Glaucoma
0.000 0.134 0.866
H40.9 Glaucoma, unspecified
0.000 0.136 0.864
M65.9 Synovitis and tenosynovitis, unspecified
0.000 0.137 0.863
L43.8 Other lichen planus
0.000 0.137 0.863
H34 Retinal vascular occlusions
0.000 0.138 0.862
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.139 0.861
L57.0 Actinic keratosis
0.000 0.140 0.860
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.143 0.857
H61.8 Other specified disorders of external ear
0.000 0.144 0.856
H60 Otitis externa
0.000 0.144 0.856
E78.1 Pure hyperglyceridaemia
0.000 0.147 0.853
M65.4 Radial styloid tenosynovitis [de Quervain]
0.000 0.148 0.852
D64.9 Anaemia, unspecified
0.000 0.154 0.846
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.154 0.846
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.157 0.843
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.158 0.842
I15 Secondary hypertension
0.000 0.158 0.842
L40.8 Other psoriasis
0.000 0.161 0.839
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.164 0.836
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.164 0.836
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.166 0.834
I20.1 Angina pectoris with documented spasm
0.000 0.174 0.826
D64 Other anaemias
0.000 0.174 0.826
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.174 0.826
M35.7 Hypermobility syndrome
0.000 0.174 0.826
E10.6 With other specified complications
0.000 0.177 0.823
Chapter VI Diseases of the nervous system
0.018 0.177 0.805
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.180 0.820
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.180 0.820
M06.34 Rheumatoid nodule (Hand)
0.000 0.181 0.819
M65.94 Synovitis and tenosynovitis, unspecified (Hand)
0.000 0.181 0.819
M31.6 Other giant cell arteritis
0.000 0.181 0.819
D60-D64 Aplastic and other anaemias
0.000 0.182 0.818
E88 Other metabolic disorders
0.000 0.188 0.812
M35.1 Other overlap syndromes
0.000 0.189 0.811
G37.8 Other specified demyelinating diseases of central nervous system
0.810 0.189 0.000
H65-H75 Diseases of middle ear and mastoid
0.000 0.194 0.806
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.196 0.804
H43.3 Other vitreous opacities
0.000 0.196 0.804
E14.4 With neurological complications
0.000 0.198 0.802
E78.6 Lipoprotein deficiency
0.000 0.199 0.801
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.798 0.201 0.000
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)
0.000 0.203 0.797
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.002 0.204 0.794
H61.1 Non-infective disorders of pinna
0.000 0.206 0.794
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.207 0.793
G50-G59 Nerve, nerve root and plexus disorders
0.001 0.208 0.791
M34.1 CR(E)ST syndrome
0.000 0.211 0.789
I12.0 Hypertensive renal disease with renal failure
0.000 0.214 0.786
L80 Vitiligo
0.000 0.214 0.786
G59 Mononeuropathy in diseases classified elsewhere
0.001 0.214 0.785
G59.0 Diabetic mononeuropathy
0.000 0.218 0.782
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.219 0.781
E11.6 With other specified complications
0.000 0.220 0.780
L85 Other epidermal thickening
0.000 0.222 0.778
E20-E35 Disorders of other endocrine glands
0.000 0.223 0.777
G56.0 Carpal tunnel syndrome
0.000 0.224 0.776
G56 Mononeuropathies of upper limb
0.000 0.224 0.776
E03.8 Other specified hypothyroidism
0.000 0.226 0.774
M35.2 Behcet's disease
0.000 0.227 0.773
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.227 0.773
I24 Other acute ischaemic heart diseases
0.000 0.228 0.772
H43.8 Other disorders of vitreous body
0.000 0.228 0.772
G63 Polyneuropathy in diseases classified elsewhere
0.001 0.228 0.771
E14.5 With peripheral circulatory complications
0.000 0.230 0.769
E11.8 With unspecified complications
0.000 0.232 0.768
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.235 0.765
M34.9 Systemic sclerosis, unspecified
0.000 0.236 0.764
E11.4 With neurological complications
0.000 0.237 0.763
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.243 0.757
E07.9 Disorder of thyroid, unspecified
0.000 0.244 0.756
M65.93 Synovitis and tenosynovitis, unspecified (Forearm)
0.000 0.245 0.755
G63.2 Diabetic polyneuropathy
0.000 0.245 0.755
L85.8 Other specified epidermal thickening
0.000 0.247 0.753
M30 Polyarteritis nodosa and related conditions
0.000 0.252 0.748
L92 Granulomatous disorders of skin and subcutaneous tissue
0.000 0.254 0.746
G61 Inflammatory polyneuropathy
0.000 0.255 0.745
H35.2 Other proliferative retinopathy
0.000 0.256 0.744
I21 Acute myocardial infarction
0.000 0.258 0.742
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.258 0.742
H60.3 Other infective otitis externa
0.000 0.259 0.741
M80-M85 Disorders of bone density and structure
0.000 0.262 0.738
H72 Perforation of tympanic membrane
0.000 0.263 0.737
I05-I09 Chronic rheumatic heart diseases
0.000 0.264 0.736
H34.8 Other retinal vascular occlusions
0.000 0.272 0.728
M65.90 Synovitis and tenosynovitis, unspecified (Multiple sites)
0.000 0.273 0.727
E13 Other specified diabetes mellitus
0.000 0.276 0.724
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.276 0.724
E14.2 Withrenal complications
0.000 0.277 0.723
M65.92 Synovitis and tenosynovitis, unspecified (Upper arm)
0.000 0.279 0.721
E16.1 Other hypoglycaemia
0.000 0.281 0.719
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E10.0 With coma
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.6 With other specified complications
0.000 0.283 0.717
E14.1 With ketoacidosis
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.3 Pustulosis palmaris et plantaris
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
I13 Hypertensive heart and renal disease
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
L44 Other papulosquamous disorders
0.000 0.283 0.717
L41 Parapsoriasis
0.000 0.283 0.717
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.2 Rheumatoid vasculitis
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.283 0.717
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.283 0.717
E16.4 Abnormal secretion of gastrin
0.000 0.283 0.717
E16.3 Increased secretion of glucagon
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.283 0.717
J33.1 Polypoid sinus degeneration
0.000 0.283 0.716
E78.3 Hyperchylomicronaemia
0.000 0.284 0.716
G36 Other acute disseminated demyelination
0.715 0.284 0.001
E77 Disorders of glycoprotein metabolism
0.000 0.284 0.715
E76 Disorders of glycosaminoglycan metabolism
0.000 0.284 0.715
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.284 0.715
E70 Disorders of aromatic amino-acid metabolism
0.000 0.284 0.715
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.284 0.715
E83 Disorders of mineral metabolism
0.311 0.285 0.404
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.285 0.715
G37.5 Concentric sclerosis [Balo]
0.714 0.285 0.000
G37.4 Subacute necrotising myelitis
0.714 0.285 0.000
G37.2 Central pontine myelinolysis
0.714 0.285 0.000
G37.1 Central demyelination of corpus callosum
0.714 0.285 0.000
G37.0 Diffuse sclerosis
0.714 0.285 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.287 0.713
L40.0 Psoriasis vulgaris
0.000 0.287 0.713
E28 Ovarian dysfunction
0.000 0.287 0.713
H43.9 Disorder of vitreous body, unspecified
0.000 0.287 0.713
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.288 0.712
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.288 0.712
M35.5 Multifocal fibrosclerosis
0.000 0.288 0.712
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.288 0.712
L43.3 Subacute (active) lichen planus
0.000 0.288 0.712
L43.2 Lichenoid drug reaction
0.000 0.288 0.712
L43.1 Bullous lichen planus
0.000 0.288 0.712
L43.0 Hypertrophic lichen planus
0.000 0.288 0.712
H43.2 Crystalline deposits in vitreous body
0.000 0.290 0.710
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.290 0.710
E74 Other disorders of carbohydrate metabolism
0.000 0.290 0.710
M14 Arthropathies in other diseases classified elsewhere
0.000 0.291 0.709
M07.5 Arthropathy in ulcerative colitis
0.000 0.291 0.708
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.291 0.708
M07.2 Psoriatic spondylitis
0.000 0.291 0.708
M07.1 Arthritis mutilans
0.000 0.291 0.708
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.291 0.708
E06.5 Other chronic thyroiditis
0.000 0.295 0.705
E06.4 Drug-induced thyroiditis
0.000 0.295 0.705
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.295 0.705
E06.1 Subacute thyroiditis
0.000 0.295 0.705
E06.0 Acute thyroiditis
0.000 0.295 0.705
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.295 0.704
M07.38 Other psoriatic arthropathies (Other)
0.000 0.296 0.703
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.296 0.703
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.296 0.703
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.296 0.703
M65.1 Other infective (teno)synovitis
0.000 0.297 0.703
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.298 0.701
H61.3 Acquired stenosis of external ear canal
0.000 0.299 0.701
I15.1 Hypertension secondary to other renal disorders
0.000 0.300 0.700
I00-I02 Acute rheumatic fever
0.000 0.300 0.700
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)
0.000 0.301 0.699
M49 Spondylopathies in diseases classified elsewhere
0.000 0.301 0.699
I22.8 Subsequent myocardial infarction of other sites
0.000 0.302 0.698
E89.2 Postprocedural hypoparathyroidism
0.000 0.303 0.697
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.306 0.694
H60.1 Cellulitis of external ear
0.000 0.310 0.690
H62 Disorders of external ear in diseases classified elsewhere
0.000 0.311 0.689
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.314 0.686
H40.4 Glaucoma secondary to eye inflammation
0.000 0.314 0.685
H30 Chorioretinal inflammation
0.000 0.315 0.685
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.317 0.683
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.317 0.683
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.317 0.683
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.317 0.683
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.317 0.683
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.317 0.683
H35.6 Retinal haemorrhage
0.000 0.317 0.683
L94 Other localised connective tissue disorders
0.000 0.317 0.683
M80 Osteoporosis with pathological fracture
0.000 0.318 0.682
E89.4 Postprocedural ovarian failure
0.000 0.320 0.680
L92.3 Foreign body granuloma of skin and subcutaneous tissue
0.000 0.320 0.680
H60.9 Otitis externa, unspecified
0.000 0.321 0.679
E06.9 Thyroiditis, unspecified
0.000 0.321 0.679
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.000 0.321 0.679
E84 Cystic fibrosis
0.000 0.321 0.679
L10-L14 Bullous disorders
0.000 0.323 0.677
M82 Osteoporosis in diseases classified elsewhere
0.000 0.323 0.677
H72.0 Central perforation of tympanic membrane
0.000 0.325 0.675
E40-E46 Malnutrition
0.000 0.327 0.673
E11.0 With coma
0.000 0.328 0.672
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.329 0.671
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.329 0.671
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.329 0.671
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.329 0.671
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.329 0.671
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.329 0.671
I23 Certain current complications following acute myocardial infarction
0.000 0.331 0.669
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.331 0.669
M06.38 Rheumatoid nodule (Other)
0.000 0.331 0.669
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.331 0.669
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.331 0.669
M06.33 Rheumatoid nodule (Forearm)
0.000 0.331 0.669
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.331 0.669
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.331 0.669
H34.2 Other retinal artery occlusions
0.000 0.332 0.668
I15.9 Seconday hypertension, unspecified
0.000 0.333 0.667
E07.8 Other specified disorders of thyroid
0.000 0.334 0.666
H35.1 Retinopathy of prematurity
0.000 0.335 0.665
M12 Other specific arthropathies
0.000 0.335 0.665
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.000 0.335 0.665
E79 Disorders of purine and pyrimidine metabolism
0.000 0.336 0.664
E23 Hypofunction and other disorders of pituitary gland
0.000 0.337 0.663
L55 Sunburn
0.000 0.340 0.660
E89.3 Postprocedural hypopituitarism
0.000 0.341 0.659
E73 Lactose intolerance
0.000 0.341 0.659
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.341 0.659
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.341 0.659
E89.5 Postprocedural testicular hypofunction
0.000 0.341 0.659
E89.1 Postprocedural hypoinsulinaemia
0.000 0.341 0.659
H42 Glaucoma in diseases classified elsewhere
0.000 0.341 0.659
M07.6 Other enteropathic arthropathies
0.000 0.341 0.658
H40.5 Glaucoma secondary to other eye disorders
0.000 0.342 0.658
M31.3 Wegener's granulomatosis
0.000 0.343 0.657
M80.9 Unspecified osteoporosis with pathological fracture
0.000 0.343 0.657
M60-M63 Disorders of muscles
0.000 0.344 0.656
L42 Pityriasis rosea
0.000 0.345 0.655
E72 Other disorders of amino-acid metabolism
0.000 0.345 0.655
G51 Facial nerve disorders
0.000 0.345 0.655
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.345 0.655
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.349 0.651
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.350 0.650
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.350 0.649
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.352 0.647
H60.4 Cholesteatoma of external ear
0.000 0.353 0.647
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.353 0.647
M34.0 Progressive systemic sclerosis
0.000 0.353 0.647
M65.2 Calcific tendinitis
0.000 0.354 0.646
M65.0 Abscess of tendon sheath
0.000 0.354 0.646
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.355 0.645
I25 Chronic ischaemic heart disease
0.000 0.355 0.645
I21.9 Acute myocardial infarction, unspecified
0.000 0.358 0.642
M34.8 Other forms of systemic sclerosis
0.000 0.360 0.640
H60.5 Acute otitis externa, non-infective
0.000 0.360 0.640
H66 Suppurative and unspecified otitis media
0.000 0.362 0.638
H34.9 Retinal vascular occlusion, unspecified
0.000 0.363 0.636
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.364 0.636
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.364 0.636
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.364 0.636
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.364 0.636
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.364 0.636
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.364 0.636
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.364 0.636
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.364 0.636
M66 Spontaneous rupture of synovium and tendon
0.000 0.364 0.636
G52 Disorders of other cranial nerves
0.001 0.365 0.634
G61.8 Other inflammatory polyneuropathies
0.000 0.366 0.633
L57.5 Actinic granuloma
0.000 0.367 0.633
L57.3 Poikiloderma of Civatte
0.000 0.367 0.633
L57.2 Cutis rhomboidalis nuchae
0.000 0.367 0.633
L57.1 Actinic reticuloid
0.000 0.367 0.633
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.367 0.633
M82.1 Osteoporosis in endocrine disorders
0.000 0.367 0.633
H43.0 Vitreous prolapse
0.000 0.368 0.632
M65.95 Synovitis and tenosynovitis, unspecified (Pelvic region and thigh)
0.000 0.368 0.632
H74 Other disorders of middle ear and mastoid
0.000 0.370 0.630
M31.9 Necrotising vasculopathy, unspecified
0.000 0.371 0.628
E28.3 Primary ovarian failure
0.000 0.372 0.628
G61.9 Inflammatory polyneuropathy, unspecified
0.000 0.372 0.627
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.373 0.627
M31.8 Other specified necrotising vasculopathies
0.000 0.374 0.626
M31.7 Microscopic polyangiitis
0.000 0.374 0.626
M31.4 Aortic arch syndrome [Takayasu]
0.000 0.374 0.626
M31.2 Lethal midline granuloma
0.000 0.374 0.626
H34.1 Central retinal artery occlusion
0.000 0.374 0.626
H66.3 Other chronic suppurative otitis media
0.000 0.376 0.624
E07.1 Dyshormogenetic goitre
0.000 0.377 0.623
E07.0 Hypersecretion of calcitonin
0.000 0.377 0.623
E29 Testicular dysfunction
0.000 0.377 0.623
G61.0 Guillain-Barre syndrome
0.000 0.377 0.623
H80-H83 Diseases of inner ear
0.000 0.378 0.622
E05.8 Other thyrotoxicosis
0.000 0.378 0.622
L57.4 Cutis laxa senilis
0.000 0.379 0.621
H40.6 Glaucoma secondary to drugs
0.000 0.379 0.621
H40.3 Glaucoma secondary to eye trauma
0.000 0.379 0.621
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.380 0.620
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.000 0.380 0.620
M65.98 Synovitis and tenosynovitis, unspecified (Other)
0.000 0.381 0.619
H34.0 Transient retinal artery occlusion
0.000 0.382 0.618
E88.8 Other specified metabolic disorders
0.000 0.382 0.617
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.384 0.616
G53 Cranial nerve disorders in diseases classified elsewhere
0.001 0.384 0.615
E03.1 Congenital hypothyroidism without goitre
0.000 0.384 0.616
D50-D53 Nutritional anaemias
0.000 0.385 0.615
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.385 0.615
E26 Hyperaldosteronism
0.000 0.385 0.615
H60.2 Malignant otitis externa
0.000 0.386 0.613
I24.8 Other forms of acute ischaemic heart disease
0.000 0.387 0.613
E88.2 Lipomatosis, not elsewhere classified
0.000 0.388 0.612
M11 Other crystal arthropathies
0.000 0.389 0.611
M65.49 Radial styloid tenosynovitis [de Quervain]-Site unspec
0.000 0.389 0.611
M65.48 Radial styloid tenosynovitis [de Quervain]-Other
0.000 0.389 0.611
M65.47 Radial styloid tenosynovitis [de Quervain]-Ankle/foot
0.000 0.389 0.611
M65.46 Radial styloid tenosynovitis [de Quervain]-Lower leg
0.000 0.389 0.611
M65.45 Radial styloid tenosynovitis [de Quervain]-Pelvic/thigh
0.000 0.389 0.611
M65.42 Radial styloid tenosynovitis [de Quervain]-Upper arm
0.000 0.389 0.611
M65.41 Radial styloid tenosynovitis [de Quervain]-Shldr region
0.000 0.389 0.611
M65.40 Radial styloid tenosynovitis [de Quervain] (Multiple sites)
0.000 0.389 0.611
I25.5 Ischaemic cardiomyopathy
0.000 0.390 0.610
G60 Hereditary and idiopathic neuropathy
0.001 0.392 0.606
M32 Systemic lupus erythematosus
0.000 0.394 0.606
E24 Cushing's syndrome
0.000 0.394 0.606
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.000 0.395 0.605
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.396 0.604
I15.8 Other secondary hypertension
0.000 0.396 0.604
I15.2 Hypertension secondary to endocrine disorders
0.000 0.396 0.604
E28.2 Polycystic ovarian syndrome
0.000 0.396 0.604
L92.0 Granuloma annulare
0.000 0.397 0.603
E88.3 Tumour lysis syndrome
0.000 0.399 0.601
H35.7 Separation of retinal layers
0.000 0.399 0.601
L58 Radiodermatitis
0.000 0.400 0.599
H43.1 Vitreous haemorrhage
0.000 0.401 0.599
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.000 0.402 0.598
L87 Transepidermal elimination disorders
0.000 0.402 0.598
L86 Keratoderma in diseases classified elsewhere
0.000 0.402 0.598
I09 Other rheumatic heart diseases
0.000 0.402 0.598
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.404 0.596
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)
0.000 0.407 0.593
I11 Hypertensive heart disease
0.000 0.407 0.593
H72.9 Perforation of tympanic membrane, unspecified
0.000 0.407 0.593
D64.4 Congenital dyserythropoietic anaemia
0.000 0.408 0.592
D64.3 Other sideroblastic anaemias
0.000 0.408 0.592
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.408 0.592
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.408 0.592
D64.0 Hereditary sideroblastic anaemia
0.000 0.408 0.592
M33 Dermatopolymyositis
0.000 0.410 0.589
Q60-Q64 Congenital malformations of the urinary system
0.000 0.412 0.588
M10 Gout
0.000 0.413 0.587
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.413 0.587
H55-H59 Other disorders of eye and adnexa
0.000 0.414 0.586
L92.9 Granulomatous disorder of skin and subcutaneous tissue, unspecified
0.000 0.414 0.586
I25.1 Atherosclerotic heart disease
0.000 0.415 0.585
M65.99 Synovitis and tenosynovitis, unspecified (Site unspecified)
0.000 0.417 0.583
I15.0 Renovascular hypertension
0.000 0.417 0.582
E88.9 Metabolic disorder, unspecified
0.000 0.418 0.582
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.418 0.582
E23.6 Other disorders of pituitary gland
0.000 0.418 0.582
L83 Acanthosis nigricans
0.000 0.420 0.580
E86 Volume depletion
0.000 0.420 0.580
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.000 0.422 0.578
H68 Eustachian salpingitis and obstruction
0.000 0.422 0.578
H67 Otitis media in diseases classified elsewhere
0.000 0.422 0.578
M30.0 Polyarteritis nodosa
0.000 0.423 0.577
Q61 Cystic kidney disease
0.000 0.423 0.577

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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