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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs34422007
log Bayes Factor = 9.49411
Chromosome 17   position 40,248,644  (GRCh37) Explore rs34422007 on Ensembl!
Variant rs34422007 is part of Cluster X0226

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I20-I25 Ischaemic heart diseases
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
1.000 0.000 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
0.999 0.001 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.998 0.002 0.000
E10-E14 Diabetes mellitus
0.998 0.002 0.000
E11 Non-insulin-dependent diabetes mellitus
0.997 0.003 0.000
I20 Angina pectoris
0.996 0.004 0.000
I73 Other peripheral vascular diseases
0.996 0.004 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.996 0.004 0.000
E11.9 Without complications
0.995 0.005 0.000
I73.9 Peripheral vascular disease, unspecified
0.993 0.007 0.000
I20.0 Unstable angina
0.991 0.009 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.989 0.011 0.000
Chapter XX External causes of morbidity and mortality
0.974 0.026 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.973 0.027 0.000
E14 Unspecified diabetes mellitus
0.960 0.040 0.000
I25.2 Old myocardial infarction
0.959 0.041 0.000
I77 Other disorders of arteries and arterioles
0.956 0.044 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.954 0.046 0.000
I25.1 Atherosclerotic heart disease
0.951 0.049 0.000
I24 Other acute ischaemic heart diseases
0.948 0.052 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.943 0.057 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.933 0.067 0.000
I71 Aortic aneurysm and dissection
0.928 0.072 0.000
E14.9 Without complications
0.925 0.075 0.000
I24.8 Other forms of acute ischaemic heart disease
0.924 0.076 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.923 0.077 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.906 0.094 0.000
T93 Sequelae of injuries of lower limb
0.905 0.095 0.000
Chapter II Neoplasms
0.893 0.107 0.000
Y40 Systemic antibiotics
0.886 0.114 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.886 0.114 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.880 0.120 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.878 0.122 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.871 0.129 0.000
C34 Malignant neoplasm of bronchus and lung
0.867 0.133 0.000
T42.4 Benzodiazepines
0.867 0.133 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.863 0.137 0.000
E11.3 With ophthalmic complications
0.861 0.139 0.000
I77.1 Stricture of artery
0.859 0.141 0.000
T51 Toxic effect of alcohol
0.858 0.142 0.000
E11.2 With renal complications
0.857 0.143 0.000
E00-E07 Disorders of thyroid gland
0.856 0.144 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.855 0.145 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.855 0.145 0.000
C34.9 Bronchus or lung, unspecified
0.852 0.148 0.000
I77.6 Arteritis, unspecified
0.845 0.155 0.000
I72 Other aneurysm
0.841 0.159 0.000
I20.1 Angina pectoris with documented spasm
0.841 0.159 0.000
S50-S59 Injuries to the elbow and forearm
0.837 0.163 0.000
E20-E35 Disorders of other endocrine glands
0.834 0.166 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.825 0.175 0.000
T92 Sequelae of injuries of upper limb
0.822 0.178 0.000
I60-I69 Cerebrovascular diseases
0.817 0.183 0.000
Y40.9 Systemic antibiotic, unspecified
0.816 0.184 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.812 0.188 0.000
T93.2 Sequelae of other fractures of lower limb
0.811 0.189 0.000
I70 Atherosclerosis
0.802 0.198 0.000
I25.5 Ischaemic cardiomyopathy
0.800 0.200 0.000
S00-S09 Injuries to the head
0.799 0.201 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.796 0.204 0.000
S90-S99 Injuries to the ankle and foot
0.796 0.204 0.000
I77.8 Other specified disorders of arteries and arterioles
0.795 0.205 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.795 0.205 0.000
E13 Other specified diabetes mellitus
0.794 0.206 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.789 0.211 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.789 0.211 0.000
E03 Other hypothyroidism
0.783 0.217 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.782 0.218 0.000
W20-W49 Exposure to inanimate mechanical forces
0.782 0.218 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.779 0.221 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.776 0.224 0.000
I21 Acute myocardial infarction
0.775 0.225 0.000
T90 Sequelae of injuries of head
0.772 0.228 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.770 0.230 0.000
I67 Other cerebrovascular diseases
0.769 0.231 0.000
T93.3 Sequelae of dislocation, sprain and strain of lower limb
0.768 0.232 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.768 0.232 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.763 0.237 0.000
S32 Fracture of lumbar spine and pelvis
0.762 0.238 0.000
Chapter V Mental and behavioural disorders
0.761 0.239 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.761 0.239 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.760 0.240 0.000
T51.0 Ethanol
0.756 0.244 0.000
Chapter VI Diseases of the nervous system
0.754 0.246 0.000
S02 Fracture of skull and facial bones
0.750 0.250 0.000
Q50-Q56 Congenital malformations of genital organs
0.749 0.251 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.749 0.251 0.000
T46.1 Calcium-channel blockers
0.747 0.253 0.000
I73.0 Raynaud's syndrome
0.744 0.256 0.000
E14.3 With ophthalmic complications
0.744 0.256 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.744 0.256 0.000
T43.2 Other and unspecified antidepressants
0.743 0.257 0.000
T59 Toxic effect of other gases, fumes and vapours
0.741 0.259 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.741 0.259 0.000
Y52 Agents primarily affecting the cardiovascular system
0.741 0.259 0.000
T58 Toxic effect of carbon monoxide
0.740 0.260 0.000
X20-X29 Contact with venomous animals and plants
0.740 0.260 0.000
C64-C68 Malignant neoplasms of urinary tract
0.738 0.262 0.000
X50-X57 Overexertion, travel and privation
0.737 0.263 0.000
T66-T78 Other and unspecified effects of external causes
0.735 0.265 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.735 0.265 0.000
X60-X84 Intentional self-harm
0.734 0.266 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.733 0.267 0.000
Q80-Q89 Other congenital malformations
0.731 0.268 0.000
E03.9 Hypothyroidism, unspecified
0.731 0.269 0.000
E22 Hyperfunction of pituitary gland
0.731 0.269 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.728 0.272 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.727 0.273 0.000
Y43 Primarily systemic agents
0.727 0.273 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.724 0.276 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.721 0.279 0.000
T63 Toxic effect of contact with venomous animals
0.719 0.280 0.000
W50-W64 Exposure to animate mechanical forces
0.719 0.281 0.000
Y44 Agents primarily affecting blood constituents
0.719 0.281 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.719 0.281 0.000
I20.8 Other forms of angina pectoris
0.719 0.281 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.719 0.281 0.000
I72.8 Aneurysm of other specified arteries
0.718 0.282 0.000
Chapter X Diseases of the respiratory system
0.718 0.282 0.000
I23 Certain current complications following acute myocardial infarction
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.717 0.283 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.717 0.283 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.717 0.283 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.717 0.283 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.717 0.283 0.000
T36 Poisoning by systemic antibiotics
0.717 0.283 0.000
I25.6 Silent myocardial ischaemia
0.716 0.284 0.000
I25.4 Coronary artery aneurysm
0.716 0.284 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.716 0.284 0.000
E12 Malnutrition-related diabetes mellitus
0.716 0.284 0.000
Q00-Q07 Congenital malformations of the nervous system
0.715 0.284 0.000
E11.8 With unspecified complications
0.715 0.285 0.000
E11.7 With multiple complications
0.715 0.285 0.000
E11.6 With other specified complications
0.715 0.285 0.000
E11.0 With coma
0.715 0.285 0.000
I73.8 Other specified peripheral vascular diseases
0.714 0.286 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.714 0.286 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.714 0.286 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.714 0.286 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.714 0.286 0.000
T42.3 Barbiturates
0.714 0.286 0.000
T42.2 Succinimides and oxazolidinediones
0.714 0.286 0.000
T42.1 Iminostilbenes
0.714 0.286 0.000
T42.0 Hydantoin derivatives
0.714 0.286 0.000
T91 Sequelae of injuries of neck and trunk
0.714 0.286 0.000
T51.9 Alcohol, unspecified
0.713 0.287 0.000
I10-I15 Hypertensive diseases
0.711 0.289 0.000
C32 Malignant neoplasm of larynx
0.707 0.293 0.000
I67.9 Cerebrovascular disease, unspecified
0.707 0.293 0.000
I67.8 Other specified cerebrovascular diseases
0.706 0.294 0.000
S50 Superficial injury of forearm
0.704 0.296 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.703 0.297 0.000
S10-S19 Injuries to the neck
0.702 0.298 0.000
Q60-Q64 Congenital malformations of the urinary system
0.700 0.300 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.700 0.300 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.699 0.300 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.700 0.300 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.699 0.301 0.000
Y35-Y36 Legal intervention and operations of war
0.698 0.302 0.000
Y10-Y34 Event of undetermined intent
0.698 0.302 0.000
Y00-Y09 Assault
0.698 0.302 0.000
X85-X99 Assault
0.698 0.302 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.698 0.302 0.000
X30-X39 Exposure to forces of nature
0.698 0.302 0.000
X10-X19 Contact with heat and hot substances
0.698 0.302 0.000
X00-X09 Exposure to smoke, fire and flames
0.698 0.302 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.698 0.302 0.000
W75-W84 Other accidental threats to breathing
0.698 0.302 0.000
W65-W74 Accidental drowning and submersion
0.698 0.302 0.000
V98-V99 Other and unspecified transport accidents
0.698 0.302 0.000
V95-V97 Air and space transport accidents
0.698 0.302 0.000
V90-V94 Water transport accidents
0.698 0.302 0.000
V80-V89 Other land transport accidents
0.698 0.302 0.000
V70-V79 Bus occupant injured in transport accident
0.698 0.302 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.698 0.302 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.698 0.302 0.000
V40-V49 Car occupant injured in transport accident
0.698 0.302 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.698 0.302 0.000
V01-V09 Pedestrian injured in transport accident
0.698 0.302 0.000
S70-S79 Injuries to the hip and thigh
0.698 0.302 0.000
I78 Diseases of capillaries
0.698 0.302 0.000
T98 Sequelae of other and unspecified effects of external causes
0.697 0.302 0.000
T95 Sequelae of burns, corrosions and frostbite
0.697 0.302 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.697 0.302 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.697 0.302 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.696 0.304 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.695 0.305 0.000
C91 Lymphoid leukaemia
0.694 0.306 0.000
W25 Contact with sharp glass
0.693 0.307 0.000
I63 Cerebral infarction
0.692 0.308 0.000
I71.0 Dissection of aorta [any part]
0.692 0.308 0.000
E40-E46 Malnutrition
0.690 0.310 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.689 0.311 0.000
E29 Testicular dysfunction
0.689 0.311 0.000
V10-V19 Pedal cyclist injured in transport accident
0.688 0.312 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.688 0.312 0.000
E14.8 With unspecified complications
0.688 0.312 0.000
E14.7 With multiple complications
0.688 0.312 0.000
E14.6 With other specified complications
0.688 0.312 0.000
E14.5 With peripheral circulatory complications
0.688 0.312 0.000
E14.4 With neurological complications
0.688 0.312 0.000
E14.2 Withrenal complications
0.688 0.312 0.000
E14.1 With ketoacidosis
0.688 0.312 0.000
E14.0 With coma
0.688 0.312 0.000
E06 Thyroiditis
0.688 0.312 0.000
T45.5 Anticoagulants
0.687 0.313 0.000
Y57 Other and unspecified drugs and medicaments
0.687 0.313 0.000
I77.5 Necrosis of artery
0.686 0.314 0.000
I77.4 Coeliac artery compression syndrome
0.686 0.314 0.000
I77.3 Arterial fibromuscular dysplasia
0.686 0.314 0.000
I77.2 Rupture of artery
0.686 0.314 0.000
I77.0 Arteriovenous fistula, acquired
0.686 0.314 0.000
Y59 Other and unspecified vaccines and biological substances
0.684 0.316 0.000
Y58 Bacterial vaccines
0.684 0.316 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.684 0.316 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.684 0.316 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.684 0.316 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.684 0.316 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.684 0.316 0.000
Y48 Anaesthetics and therapeutic gases
0.684 0.316 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.684 0.316 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.684 0.316 0.000
C34.1 Upper lobe, bronchus or lung
0.684 0.316 0.000
T40.4 Other synthetic narcotics
0.680 0.320 0.000
T45.1 Antineoplastic and immunosuppressive drugs
0.680 0.320 0.000
S30.0 Contusion of lower back and pelvis
0.680 0.320 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.680 0.320 0.000
I24.1 Dressler's syndrome
0.679 0.320 0.000
Y40.1 Cefalosporins and other -lactam antibiotics
0.679 0.321 0.000
Y40.0 Penicillins
0.679 0.321 0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.677 0.323 0.000
T65 Toxic effect of other and unspecified substances
0.676 0.324 0.000
T62 Toxic effect of other noxious substances eaten as food
0.676 0.324 0.000
T61 Toxic effect of noxious substances eaten as seafood
0.676 0.324 0.000
T60 Toxic effect of pesticides
0.676 0.324 0.000
T57 Toxic effect of other inorganic substances
0.676 0.324 0.000
T56 Toxic effect of metals
0.676 0.324 0.000
T54 Toxic effect of corrosive substances
0.676 0.324 0.000
T53 Toxic effect of halogen derivatives of aliphatic and aromatic hydrocarbone
0.676 0.324 0.000
T52 Toxic effect of organic solvents
0.676 0.324 0.000
T64 Toxic effect of aflatoxin and other mycotoxin food contaminants
0.676 0.324 0.000
T55 Toxic effect of soaps and detergents
0.676 0.324 0.000
I05-I09 Chronic rheumatic heart diseases
0.675 0.325 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.675 0.325 0.000
C34.3 Lower lobe, bronchus or lung
0.675 0.325 0.000
I20.9 Angina pectoris, unspecified
0.673 0.327 0.000
G62 Other polyneuropathies
0.673 0.327 0.000
S30.8 Other superficial injuries of abdomen, lower back and pelvis
0.672 0.328 0.000
I30-I52 Other forms of heart disease
0.672 0.328 0.000
T92.1 Sequelae of fracture of arm
0.672 0.328 0.000
Y54.5 Other diuretics
0.671 0.329 0.000
W00-W19 Falls
0.669 0.331 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.668 0.331 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.668 0.332 0.000
T79-T79 Certain early complications of trauma
0.668 0.332 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.665 0.334 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.665 0.334 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.665 0.334 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.665 0.334 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.665 0.334 0.000
E11.5 With peripheral circulatory complications
0.665 0.335 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.661 0.338 0.000
Q35-Q37 Cleft lip and cleft palate
0.661 0.338 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.661 0.338 0.000
S32.4 Fracture of acetabulum
0.661 0.339 0.000
T46.4 Angiotensin-converting-enzyme inhibitors
0.661 0.339 0.000
C51-C58 Malignant neoplasms of female genital organs
0.660 0.340 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.660 0.340 0.000
C64 Malignant neoplasm of kidney, except renal pelvis
0.657 0.343 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.657 0.343 0.000
V20-V29 Motorcycle rider injured in transport accident
0.655 0.345 0.000
T93.8 Sequelae of other specified injuries of lower limb
0.654 0.345 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.652 0.348 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.651 0.349 0.000
S06 Intracranial injury
0.651 0.349 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.651 0.349 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.650 0.349 0.000
D46 Myelodysplastic syndromes
0.650 0.350 0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis
0.649 0.350 0.000
S37 Injury of urinary and pelvic organs
0.649 0.350 0.000
S36 Injury of intra-abdominal organs
0.649 0.350 0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level
0.649 0.350 0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level
0.649 0.350 0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis
0.649 0.350 0.000
S31 Open wound of abdomen, lower back and pelvis
0.649 0.350 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.649 0.350 0.000
S91 Open wound of ankle and foot
0.649 0.350 0.000
S02.2 Fracture of nasal bones
0.649 0.351 0.000
T93.9 Sequelae of unspecified injury of lower limb
0.649 0.351 0.000
T93.6 Sequelae of crushing injury and traumatic amputation of lower limb
0.649 0.351 0.000
T93.5 Sequelae of injury of muscle and tendon of lower limb
0.649 0.351 0.000
T93.4 Sequelae of injury of nerve of lower limb
0.649 0.351 0.000
T93.1 Sequelae of fracture of femur
0.649 0.351 0.000
T93.0 Sequelae of open wound of lower limb
0.649 0.351 0.000
E13.9 Without complications
0.647 0.353 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.647 0.353 0.000
T45.0 Antiallergic and antiemetic drugs
0.647 0.353 0.000
G90-G99 Other disorders of the nervous system
0.646 0.354 0.000
J95-J99 Other diseases of the respiratory system
0.645 0.355 0.000
Y79 Orthopaedic devices associated with adverse incidents
0.645 0.355 0.000
I51 Complications and ill-defined descriptions of heart disease
0.645 0.355 0.000
I74 Arterial embolism and thrombosis
0.645 0.355 0.000
D45 Polycythaemia vera
0.644 0.356 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.643 0.357 0.000
T92.9 Sequelae of unspecified injury of upper limb
0.642 0.358 0.000
E11.1 With ketoacidosis
0.642 0.358 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.640 0.360 0.000
D60-D64 Aplastic and other anaemias
0.639 0.361 0.000
I70.2 Atherosclerosis of arteries of the extremities
0.637 0.363 0.000
Y40.7 Antifungal antibiotics, systemically used
0.635 0.365 0.000
Y40.6 Rifamycins
0.635 0.365 0.000
Y40.5 Aminoglycosides
0.635 0.365 0.000
Y40.4 Tetracyclines
0.635 0.365 0.000
Y40.3 Macrolides
0.635 0.365 0.000
Y40.2 Chloramphenicol group
0.635 0.365 0.000
T43.9 Psychotropic drug, unspecified
0.635 0.365 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.635 0.365 0.000
T43.6 Psychostimulants with abuse potential
0.635 0.365 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.635 0.365 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.635 0.365 0.000
I25.3 Aneurysm of heart
0.634 0.366 0.000
S56 Injury of muscle and tendon at forearm level
0.633 0.367 0.000
I22 Subsequent myocardial infarction
0.633 0.367 0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs
0.631 0.369 0.000
C38 Malignant neoplasm of heart, mediastinum and pleura
0.631 0.369 0.000
C31 Malignant neoplasm of accessory sinuses
0.631 0.369 0.000
C30 Malignant neoplasm of nasal cavity and middle ear
0.631 0.369 0.000
C37 Malignant neoplasm of thymus
0.631 0.369 0.000
C33 Malignant neoplasm of trachea
0.631 0.369 0.000
Y40.8 Other systemic antibiotics
0.631 0.369 0.000
T39.1 4-Aminophenol derivatives
0.631 0.369 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.630 0.370 0.000
T90.8 Sequelae of other specified injuries of head
0.630 0.370 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.630 0.370 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.629 0.370 0.000
W25.9 Unspecified place
0.630 0.370 0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.629 0.370 0.000
T46.8 Antivaricose drugs, including sclerosing agents
0.629 0.370 0.000
T46.7 Peripheral vasodilators
0.629 0.370 0.000
T46.5 Other antihypertensive drugs, not elsewhere classified
0.629 0.370 0.000
T46.3 Coronary vasodilators, not elsewhere classified
0.629 0.370 0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.629 0.370 0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.629 0.370 0.000
I72.3 Aneurysm of iliac artery
0.629 0.371 0.000
Q51 Congenital malformations of uterus and cervix
0.628 0.372 0.000
I72.0 Aneurysm of carotid artery
0.628 0.372 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.628 0.372 0.000
F43 Reaction to severe stress, and adjustment disorders
0.627 0.373 0.000
T11 Other injuries of upper limb, level unspecified
0.626 0.373 0.000
I63.9 Cerebral infarction, unspecified
0.626 0.374 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.625 0.375 0.000
T50.8 Diagnostic agents
0.625 0.375 0.000
T50.7 Analeptics and opioid receptor antagonists
0.625 0.375 0.000
T50.6 Antidotes and chelating agents, not elsewhere classified
0.625 0.375 0.000
T50.5 Appetite depressants
0.625 0.375 0.000
T50.4 Drugs affecting uric acid metabolism
0.625 0.375 0.000
T50.3 Electrolytic, caloric and water-balance agents
0.625 0.375 0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.625 0.375 0.000
T50.1 Loop [high-ceiling] diuretics
0.625 0.375 0.000
T50.0 Mineralocorticoids and their antagonists
0.625 0.375 0.000
C34.0 Main bronchus
0.624 0.376 0.000
I67.0 Dissection of cerebral arteries, nonruptured
0.623 0.376 0.000
C34.8 Overlapping lesion of bronchus and lung
0.622 0.378 0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.620 0.380 0.000
C74 Malignant neoplasm of adrenal gland
0.620 0.380 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.618 0.382 0.000
S02.4 Fracture of malar and maxillary bones
0.615 0.385 0.000
T51.8 Other alcohols
0.615 0.385 0.000
T51.3 Fusel oil
0.615 0.385 0.000
T51.2 2-Propanol
0.615 0.385 0.000
T51.1 Methanol
0.615 0.385 0.000
E11.4 With neurological complications
0.614 0.386 0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs
0.614 0.386 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.613 0.386 0.000
E00 Congenital iodine-deficiency syndrome
0.613 0.386 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.613 0.386 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.613 0.387 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.613 0.387 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.613 0.387 0.000
T39.4 Antirheumatics, not elsewhere classified
0.613 0.387 0.000
T39.2 Pyrazolone derivatives
0.613 0.387 0.000
T45.9 Primarily systemic and haematological agent, unspecified
0.613 0.387 0.000
T45.8 Other primarily systemic and haematological agents
0.613 0.387 0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.613 0.387 0.000
T45.6 Fibrinolysis-affecting drugs
0.613 0.387 0.000
T45.4 Iron and its compounds
0.613 0.387 0.000
T45.3 Enzymes, not elsewhere classified
0.613 0.387 0.000
T45.2 Vitamins, not elsewhere classified
0.613 0.387 0.000
E23 Hypofunction and other disorders of pituitary gland
0.613 0.387 0.000
C73 Malignant neoplasm of thyroid gland
0.613 0.387 0.000
T94.1 Sequelae of injuries, not specified by body region
0.612 0.388 0.000
X41 Accidental poisoning by and exposure to antiepileptic, sedative-hypnotic, anti-Parkinsonism and psychotropic drugs, not elsewhere classified
0.610 0.390 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.610 0.390 0.000
S50.9 Superficial injury of forearm, unspecified
0.609 0.391 0.000
R20 Disturbances of skin sensation
0.609 0.391 0.000
E26 Hyperaldosteronism
0.608 0.391 0.000
T92.3 Sequelae of dislocation, sprain and strain of upper limb
0.607 0.393 0.000
I70.0 Atherosclerosis of aorta
0.606 0.393 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.606 0.394 0.000
E07 Other disorders of thyroid
0.605 0.395 0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.605 0.395 0.000
I51.7 Cardiomegaly
0.605 0.395 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.603 0.396 0.000
I72.9 Aneurysm of unspecified site
0.603 0.397 0.000
I72.6 Aneurysm and dissection of vertebral artery
0.603 0.397 0.000
I72.5 Aneurysm and dissection of other precerebral arteries
0.603 0.397 0.000
I72.2 Aneurysm of renal artery
0.603 0.397 0.000
I72.1 Aneurysm of artery of upper extremity
0.603 0.397 0.000
C34.2 Middle lobe, bronchus or lung
0.602 0.398 0.000
G62.9 Polyneuropathy, unspecified
0.602 0.398 0.000
C91.4 Hairy-cell leukaemia
0.602 0.398 0.000
C01 Malignant neoplasm of base of tongue
0.600 0.400 0.000
S59 Other and unspecified injuries of forearm
0.600 0.400 0.000
S58 Traumatic amputation of forearm
0.600 0.400 0.000
S57 Crushing injury of forearm
0.600 0.400 0.000
S55 Injury of blood vessels at forearm level
0.600 0.400 0.000
S54 Injury of nerves at forearm level
0.600 0.400 0.000
S53 Dislocation, sprain and strain of joints and ligaments of elbow
0.600 0.400 0.000
Chapter VII Diseases of the eye and adnexa
0.600 0.400 0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.599 0.401 0.000
I21.9 Acute myocardial infarction, unspecified
0.599 0.401 0.000
R20.8 Other and unspecified disturbances of skin sensation
0.599 0.401 0.000
F60-F69 Disorders of adult personality and behaviour
0.598 0.402 0.000
G61 Inflammatory polyneuropathy
0.598 0.402 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.598 0.402 0.000
E34 Other endocrine disorders
0.598 0.402 0.000
E32 Diseases of thymus
0.598 0.402 0.000
E31 Polyglandular dysfunction
0.598 0.402 0.000
E30 Disorders of puberty, not elsewhere classified
0.598 0.402 0.000
E25 Adrenogenital disorders
0.598 0.402 0.000
E24 Cushing's syndrome
0.598 0.402 0.000
E20 Hypoparathyroidism
0.598 0.402 0.000
S52 Fracture of forearm
0.597 0.402 0.000
S51 Open wound of forearm
0.597 0.402 0.000
T59.8 Other specified gases, fumes and vapours
0.597 0.403 0.000
Q87 Other specified congenital malformation syndromes affecting multiple systems
0.594 0.405 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.592 0.408 0.000
F44 Dissociative [conversion] disorders
0.592 0.408 0.000
T90.2 Sequelae of fracture of skull and facial bones
0.591 0.409 0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.591 0.409 0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.591 0.409 0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.591 0.409 0.000
X49 Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances
0.589 0.411 0.000
T92.8 Sequelae of other specified injuries of upper limb
0.589 0.411 0.000
T92.6 Sequelae of crushing injury and traumatic amputation of upper limb
0.589 0.411 0.000
T92.5 Sequelae of injury of muscle and tendon of upper limb
0.589 0.411 0.000
T92.4 Sequelae of injury of nerve of upper limb
0.589 0.411 0.000
T92.0 Sequelae of open wound of upper limb
0.589 0.411 0.000
E27 Other disorders of adrenal gland
0.589 0.411 0.000
S02.3 Fracture of orbital floor
0.589 0.411 0.000
S32.40 Fracture of acetabulum (closed)
0.588 0.411 0.000
E50-E64 Other nutritional deficiencies
0.588 0.412 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.586 0.414 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.586 0.414 0.000
T92.2 Sequelae of fracture at wrist and hand level
0.585 0.415 0.000
E29.1 Testicular hypofunction
0.585 0.415 0.000
C92 Myeloid leukaemia
0.585 0.415 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.584 0.416 0.000
C32.1 Supraglottis
0.584 0.416 0.000
W44 Foreign body entering into or through eye or natural orifice
0.584 0.416 0.000
I15 Secondary hypertension
0.584 0.416 0.000
I12 Hypertensive renal disease
0.584 0.416 0.000
C91.1 Chronic lymphocytic leukaemia
0.583 0.417 0.000
F80-F89 Disorders of psychological development
0.583 0.417 0.000
T14 Injury of unspecified body region
0.581 0.419 0.000
W21 Striking against or struck by sports equipment
0.581 0.419 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.581 0.419 0.000
Y86 Sequelae of other accidents
0.581 0.419 0.000
S92 Fracture of foot, except ankle
0.579 0.421 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.578 0.422 0.000
S02.20 Fracture of nasal bones (closed)
0.576 0.423 0.000
Y43.4 Immunosuppressive agents
0.576 0.424 0.000
S02.0 Fracture of vault of skull
0.576 0.424 0.000
I70.9 Generalised and unspecified atherosclerosis
0.575 0.425 0.000
I70.8 Atherosclerosis of other arteries
0.575 0.425 0.000
I70.1 Atherosclerosis of renal artery
0.575 0.425 0.000
S32.7 Multiple fractures of lumbar spine and pelvis
0.574 0.426 0.000
C53 Malignant neoplasm of cervix uteri
0.574 0.426 0.000
S08 Traumatic amputation of part of head
0.573 0.427 0.000
S07 Crushing injury of head
0.573 0.427 0.000
S04 Injury of cranial nerves
0.573 0.427 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.573 0.427 0.000
X23 Contact with hornets, wasps and bees
0.572 0.428 0.000
D43.2 Brain, unspecified
0.572 0.428 0.000
S30.7 Multiple superficial injuries of abdomen, lower back and pelvis
0.571 0.429 0.000
S30.2 Contusion of external genital organs
0.571 0.429 0.000
S99 Other and unspecified injuries of ankle and foot
0.570 0.429 0.000
S98 Traumatic amputation of ankle and foot
0.570 0.429 0.000
S97 Crushing injury of ankle and foot
0.570 0.429 0.000
S96 Injury of muscle and tendon at ankle and foot level
0.570 0.429 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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