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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3764021
log Bayes Factor = 5.72645
Chromosome 12   position 9,833,628  (GRCh37) Explore rs3764021 on Ensembl!
Variant rs3764021 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.007 0.993
E03 Other hypothyroidism
0.000 0.011 0.989
E10.3 With ophthalmic complications
0.000 0.012 0.988
E00-E07 Disorders of thyroid gland
0.000 0.015 0.985
E10-E14 Diabetes mellitus
0.000 0.017 0.983
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.018 0.982
E10.5 With peripheral circulatory complications
0.000 0.026 0.974
E20-E35 Disorders of other endocrine glands
0.000 0.032 0.968
E06 Thyroiditis
0.000 0.060 0.940
E06.3 Autoimmune thyroiditis
0.000 0.087 0.913
E10.4 With neurological complications
0.000 0.106 0.894
E34 Other endocrine disorders
0.000 0.113 0.887
E22 Hyperfunction of pituitary gland
0.000 0.129 0.871
E10.2 With renal complications
0.000 0.132 0.868
E10.8 With unspecified complications
0.000 0.141 0.859
E34.9 Endocrine disorder, unspecified
0.000 0.157 0.843
E20 Hypoparathyroidism
0.000 0.164 0.836
E10.1 With ketoacidosis
0.000 0.176 0.824
E24 Cushing's syndrome
0.000 0.189 0.811
E23 Hypofunction and other disorders of pituitary gland
0.000 0.209 0.791
E22.1 Hyperprolactinaemia
0.000 0.221 0.779
E25 Adrenogenital disorders
0.000 0.221 0.779
E07 Other disorders of thyroid
0.000 0.224 0.776
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.229 0.771
E13 Other specified diabetes mellitus
0.000 0.239 0.761
E23.2 Diabetes insipidus
0.000 0.253 0.747
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.255 0.745
E20.9 Hypoparathyroidism, unspecified
0.000 0.260 0.740
E24.9 Cushing's syndrome, unspecified
0.000 0.260 0.740
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.269 0.731
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.270 0.730
E10.0 With coma
0.000 0.272 0.728
E27 Other disorders of adrenal gland
0.000 0.281 0.719
E10.7 With multiple complications
0.000 0.288 0.712
E03.5 Myxoedema coma
0.000 0.291 0.709
E03.4 Atrophy of thyroid (acquired)
0.000 0.291 0.709
E03.3 Postinfectious hypothyroidism
0.000 0.291 0.709
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.294 0.706
E00 Congenital iodine-deficiency syndrome
0.000 0.294 0.706
E12 Malnutrition-related diabetes mellitus
0.000 0.295 0.705
E06.1 Subacute thyroiditis
0.000 0.301 0.699
E28 Ovarian dysfunction
0.000 0.304 0.696
E10.9 Without complications
0.000 0.305 0.695
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.306 0.694
E32 Diseases of thymus
0.000 0.306 0.694
E30 Disorders of puberty, not elsewhere classified
0.000 0.306 0.694
E06.5 Other chronic thyroiditis
0.000 0.317 0.683
E06.4 Drug-induced thyroiditis
0.000 0.326 0.674
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.326 0.674
E06.0 Acute thyroiditis
0.000 0.326 0.674
E34.0 Carcinoid syndrome
0.000 0.339 0.661
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.341 0.659
E07.8 Other specified disorders of thyroid
0.000 0.341 0.659
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.345 0.655
E29 Testicular dysfunction
0.000 0.354 0.646
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.357 0.643
E34.5 Androgen resistance syndrome
0.000 0.364 0.636
E34.4 Constitutional tall stature
0.000 0.364 0.636
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.364 0.636
E34.1 Other hypersecretion of intestinal hormones
0.000 0.364 0.636
E40-E46 Malnutrition
0.000 0.364 0.636
E34.3 Short stature, not elsewhere classified
0.000 0.366 0.634
E31 Polyglandular dysfunction
0.000 0.369 0.631
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.376 0.624
E22.8 Other hyperfunction of pituitary gland
0.000 0.376 0.624
E13.9 Without complications
0.000 0.376 0.624
E28.3 Primary ovarian failure
0.000 0.395 0.605
E03.8 Other specified hypothyroidism
0.000 0.397 0.603
E20.8 Other hypoparathyroidism
0.000 0.401 0.599
E20.1 Pseudohypoparathyroidism
0.000 0.401 0.599
E20.0 Idiopathic hypoparathyroidism
0.000 0.401 0.599
E06.9 Thyroiditis, unspecified
0.000 0.411 0.589
E24.8 Other Cushing's syndrome
0.000 0.418 0.581
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.418 0.581
E24.3 Ectopic ACTH syndrome
0.000 0.418 0.581
E24.1 Nelson's syndrome
0.000 0.418 0.581
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.427 0.573
E27.9 Disorder of adrenal gland, unspecified
0.000 0.429 0.571
E24.0 Pituitary-dependent Cushing's disease
0.000 0.431 0.569
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.433 0.567
E23.1 Drug-induced hypopituitarism
0.000 0.433 0.567
E25.9 Adrenogenital disorder, unspecified
0.000 0.442 0.558
E25.8 Other adrenogenital disorders
0.000 0.442 0.558
E07.1 Dyshormogenetic goitre
0.000 0.444 0.556
E07.0 Hypersecretion of calcitonin
0.000 0.444 0.556
E27.2 Addisonian crisis
0.000 0.453 0.547
E13.8 With unspecified complications
0.000 0.454 0.545
E13.7 With multiple complications
0.000 0.454 0.545
E13.6 With other specified complications
0.000 0.454 0.545
E13.5 With peripheral circulatory complications
0.000 0.454 0.545
E13.4 With neurological complications
0.000 0.454 0.545
E13.2 With renal complications
0.000 0.454 0.545
E13.1 With ketoacidosis
0.000 0.454 0.545
E13.0 With coma
0.000 0.454 0.545
E22.0 Acromegaly and pituitary gigantism
0.000 0.457 0.542
E10.6 With other specified complications
0.000 0.469 0.531
E27.8 Other specified disorders of adrenal gland
0.000 0.470 0.530
E34.8 Other specified endocrine disorders
0.000 0.472 0.528
E23.6 Other disorders of pituitary gland
0.000 0.477 0.523
E27.1 Primary adrenocortical insufficiency
0.000 0.484 0.516
E27.5 Adrenomedullary hyperfunction
0.000 0.485 0.515
E27.0 Other adrenocortical overactivity
0.000 0.485 0.515
E21.3 Hyperparathyroidism, unspecified
0.000 0.486 0.514
E13.3 With ophthalmic complications
0.000 0.489 0.511
E03.1 Congenital hypothyroidism without goitre
0.001 0.492 0.508
E23.0 Hypopituitarism
0.000 0.492 0.508
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.494 0.506
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.494 0.506
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.494 0.506
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.494 0.506
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.494 0.506
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.494 0.506
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.494 0.506
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.494 0.506
E12.9 Without complications
0.000 0.494 0.505
E12.8 With unspecified complications
0.000 0.494 0.505
E12.7 With multiple complications
0.000 0.494 0.505
E12.6 With other specified complications
0.000 0.494 0.505
E12.5 With peripheral circulatory complications
0.000 0.494 0.505
E12.4 With neurological complications
0.000 0.494 0.505
E12.3 With ophthalmic complications
0.000 0.494 0.505
E12.2 With renal complications
0.000 0.494 0.505
E12.1 With ketoacidosis
0.000 0.494 0.505
E12.0 With coma
0.000 0.494 0.505
E21.2 Other hyperparathyroidism
0.000 0.498 0.502
E28.9 Ovarian dysfunction, unspecified
0.000 0.501 0.499
E28.8 Other ovarian dysfunction
0.000 0.501 0.499
E28.1 Androgen excess
0.000 0.501 0.499
E28.0 Oestrogen excess
0.000 0.501 0.499
E30.9 Disorder of puberty, unspecified
0.000 0.502 0.498
E30.8 Other disorders of puberty
0.000 0.502 0.498
E30.1 Precocious puberty
0.000 0.502 0.498
E30.0 Delayed puberty
0.000 0.502 0.498
E32.9 Disease of thymus, unspecified
0.000 0.502 0.498
E32.8 Other diseases of thymus
0.000 0.502 0.498
E32.1 Abscess of thymus
0.000 0.502 0.498
E32.0 Persistent hyperplasia of thymus
0.000 0.502 0.498
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.502 0.498
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.502 0.498
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.502 0.498
E07.9 Disorder of thyroid, unspecified
0.000 0.505 0.495
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.510 0.490
E15 Nondiabetic hypoglycaemic coma
0.000 0.530 0.469
E21.4 Other specified disorders of parathyroid gland
0.000 0.531 0.469
E24.2 Drug-induced Cushing's syndrome
0.000 0.531 0.468
E26 Hyperaldosteronism
0.001 0.535 0.465
E29.8 Other testicular dysfunction
0.000 0.537 0.463
E29.0 Testicular hyperfunction
0.000 0.537 0.463
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.544 0.456
E45 Retarded development following protein-energy malnutrition
0.000 0.544 0.456
E43 Unspecified severe protein-energy malnutrition
0.000 0.544 0.456
E42 Marasmic kwashiorkor
0.000 0.544 0.456
E41 Nutritional marasmus
0.000 0.544 0.456
E40 Kwashiorkor
0.000 0.544 0.456
E31.9 Polyglandular dysfunction, unspecified
0.000 0.548 0.452
E31.8 Other polyglandular dysfunction
0.000 0.548 0.452
E31.1 Polyglandular hyperfunction
0.000 0.548 0.452
E29.9 Testicular dysfunction, unspecified
0.000 0.554 0.445
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.564 0.436
E29.1 Testicular hypofunction
0.000 0.565 0.435
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.569 0.431
E65-E68 Obesity and other hyperalimentation
0.000 0.576 0.423
E16 Other disorders of pancreatic internal secretion
0.000 0.580 0.420
E50-E64 Other nutritional deficiencies
0.000 0.599 0.401
E11 Non-insulin-dependent diabetes mellitus
0.000 0.605 0.395
E31.0 Autoimmune polyglandular failure
0.000 0.611 0.389
E46 Unspecified protein-energy malnutrition
0.000 0.612 0.388
E23.7 Disorder of pituitary gland, unspecified
0.001 0.636 0.363
E11.5 With peripheral circulatory complications
0.000 0.648 0.352
E11.1 With ketoacidosis
0.000 0.658 0.342
E26.8 Other hyperaldosteronism
0.001 0.666 0.333
E26.1 Secondary hyperaldosteronism
0.001 0.666 0.333
E44.1 Mild protein-energy malnutrition
0.000 0.673 0.327
E44.0 Moderate protein-energy malnutrition
0.000 0.673 0.327
E67 Other hyperalimentation
0.000 0.696 0.304
E68 Sequelae of hyperalimentation
0.000 0.696 0.304
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.698 0.301
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.698 0.301
E16.4 Abnormal secretion of gastrin
0.000 0.698 0.301
E16.3 Increased secretion of glucagon
0.000 0.698 0.301
E61 Deficiency of other nutrient elements
0.000 0.699 0.301
E16.2 Hypoglycaemia, unspecified
0.000 0.699 0.301
E26.9 Hyperaldosteronism, unspecified
0.001 0.699 0.300
E16.1 Other hypoglycaemia
0.000 0.700 0.300
E11.6 With other specified complications
0.000 0.701 0.299
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.712 0.287
E50 Vitamin A deficiency
0.000 0.712 0.287
E60 Dietary zinc deficiency
0.000 0.712 0.287
E59 Dietary selenium deficiency
0.000 0.712 0.287
E52 Niacin deficiency [pellagra]
0.000 0.712 0.287
E14 Unspecified diabetes mellitus
0.000 0.716 0.284
E11.7 With multiple complications
0.000 0.717 0.283
E56 Other vitamin deficiencies
0.000 0.717 0.283
E54 Ascorbic acid deficiency
0.000 0.726 0.274
E51 Thiamine deficiency
0.000 0.727 0.273
E28.2 Polycystic ovarian syndrome
0.000 0.728 0.272
E58 Dietary calcium deficiency
0.000 0.734 0.266
E63 Other nutritional deficiencies
0.000 0.735 0.265
E11.2 With renal complications
0.000 0.736 0.264
E53 Deficiency of other B group vitamins
0.000 0.737 0.263
E11.0 With coma
0.000 0.742 0.258
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.745 0.255
E11.8 With unspecified complications
0.000 0.759 0.241
E66 Obesity
0.000 0.761 0.239
E14.6 With other specified complications
0.000 0.762 0.238
E61.1 Iron deficiency
0.000 0.763 0.236
E11.4 With neurological complications
0.000 0.772 0.228
E14.2 Withrenal complications
0.000 0.774 0.226
E14.5 With peripheral circulatory complications
0.000 0.782 0.218
E67.8 Other specified hyperalimentation
0.000 0.782 0.218
E67.3 Hypervitaminosis D
0.000 0.782 0.218
E67.2 Megavitamin-B6 syndrome
0.000 0.782 0.218
E67.1 Hypercarotenaemia
0.000 0.782 0.218
E67.0 Hypervitaminosis A
0.000 0.782 0.218
E61.9 Deficiency of nutrient element, unspecified
0.000 0.784 0.216
E61.8 Deficiency of other specified nutrient elements
0.000 0.784 0.216
E61.7 Deficiency of multiple nutrient elements
0.000 0.784 0.216
E61.6 Vanadium deficiency
0.000 0.784 0.216
E61.5 Molybdenum deficiency
0.000 0.784 0.216
E61.4 Chromium deficiency
0.000 0.784 0.216
E61.3 Manganese deficiency
0.000 0.784 0.216
E61.0 Copper deficiency
0.000 0.784 0.216
E66.0 Obesity due to excess calories
0.000 0.784 0.216
E61.2 Magnesium deficiency
0.000 0.792 0.208
E50.9 Vitamin A deficiency, unspecified
0.000 0.794 0.206
E50.8 Other manifestations of vitamin A deficiency
0.000 0.794 0.206
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.794 0.206
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.794 0.206
E50.5 Vitamin A deficiency with night blindness
0.000 0.794 0.206
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.794 0.206
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.794 0.206
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.794 0.206
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.794 0.206
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.794 0.206
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.794 0.206
E64.8 Sequelae of other nutritional deficiencies
0.000 0.794 0.206
E64.3 Sequelae of rickets
0.000 0.794 0.206
E64.2 Sequelae of vitamin C deficiency
0.000 0.794 0.206
E64.1 Sequelae of vitamin A deficiency
0.000 0.794 0.206
E64.0 Sequelae of protein-energy malnutrition
0.000 0.794 0.206
E53.9 Vitamin B deficiency, unspecified
0.000 0.795 0.205
E14.7 With multiple complications
0.000 0.796 0.204
E56.9 Vitamin deficiency, unspecified
0.000 0.797 0.203
E56.8 Deficiency of other vitamins
0.000 0.797 0.203
E56.0 Deficiency of vitamin E
0.000 0.797 0.203
E56.1 Deficiency of vitamin K
0.000 0.802 0.198
E51.9 Thiamine deficiency, unspecified
0.000 0.804 0.196
E51.8 Other manifestations of thiamine deficiency
0.000 0.804 0.196
E51.1 Beriberi
0.000 0.804 0.196
E55 Vitamin D deficiency
0.000 0.808 0.192
E14.1 With ketoacidosis
0.000 0.809 0.191
E63.8 Other specified nutritional deficiencies
0.000 0.810 0.190
E63.1 Imbalance of constituents of food intake
0.000 0.810 0.190
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.810 0.190
E53.1 Pyridoxine deficiency
0.000 0.811 0.189
E53.0 Riboflavin deficiency
0.000 0.811 0.189
E14.0 With coma
0.000 0.812 0.188
E51.2 Wernicke's encephalopathy
0.000 0.818 0.182
E14.8 With unspecified complications
0.000 0.818 0.182
E26.0 Primary hyperaldosteronism
0.001 0.823 0.176
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.824 0.176
E66.1 Drug-induced obesity
0.000 0.828 0.171
E14.4 With neurological complications
0.000 0.833 0.167
E63.9 Nutritional deficiency, unspecified
0.000 0.833 0.167
E65 Localised adiposity
0.001 0.836 0.163
E55.0 Rickets, active
0.000 0.862 0.138
E53.8 Deficiency of other specified B group vitamins
0.000 0.862 0.138
E66.8 Other obesity
0.000 0.887 0.113
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.894 0.106
E21.0 Primary hyperparathyroidism
0.000 0.916 0.083
E11.3 With ophthalmic complications
0.000 0.919 0.081
E11.9 Without complications
0.000 0.924 0.076
E05.5 Thyroid crisis or storm
0.000 0.924 0.076
E05.4 Thyrotoxicosis factitia
0.000 0.924 0.076
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.924 0.076
E14.9 Without complications
0.000 0.929 0.071
E04 Other non-toxic goitre
0.001 0.929 0.070
E14.3 With ophthalmic complications
0.000 0.932 0.067
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.933 0.067
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.940 0.060
E05.8 Other thyrotoxicosis
0.000 0.941 0.058
E04.8 Other specified non-toxic goitre
0.001 0.949 0.050
E55.9 Vitamin D deficiency, unspecified
0.000 0.957 0.043
E04.0 Non-toxic diffuse goitre
0.001 0.958 0.042
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.965 0.035
E66.9 Obesity, unspecified
0.000 0.978 0.022
E05.9 Thyrotoxicosis, unspecified
0.000 0.979 0.021
E04.2 Non-toxic multinodular goitre
0.000 0.981 0.019
E04.9 Non-toxic goitre, unspecified
0.000 0.983 0.017
R54 Senility
0.011 0.989 0.000
N75.0 Cyst of Bartholin's gland
0.000 0.990 0.010
Z37.2 Twins, both liveborn
0.000 0.992 0.008
N60.8 Other benign mammary dysplasias
0.000 0.994 0.006
D86 Sarcoidosis
0.006 0.994 0.000
D86.9 Sarcoidosis, unspecified
0.006 0.994 0.000
D12.6 Colon, unspecified
0.000 0.994 0.006
D86.8 Sarcoidosis of other and combined sites
0.006 0.994 0.000
E04.1 Non-toxic single thyroid nodule
0.002 0.994 0.004
N81.8 Other female genital prolapse
0.000 0.994 0.006
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.005 0.994 0.000
Z63.8 Other specified problems related to primary support group
0.005 0.995 0.000
D86.0 Sarcoidosis of lung
0.005 0.995 0.000
S05.0 Injury of conjunctiva and corneal abrasion without mention of foreign body
0.005 0.995 0.000
S05 Injury of eye and orbit
0.005 0.995 0.000
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
0.000 0.995 0.005
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.995 0.005
S02.20 Fracture of nasal bones (closed)
0.000 0.995 0.005
D86.1 Sarcoidosis of lymph nodes
0.004 0.995 0.000
S05.9 Injury of eye and orbit, part unspecified
0.005 0.995 0.000
S01.7 Multiple open wounds of head
0.000 0.995 0.004
D86.3 Sarcoidosis of skin
0.004 0.996 0.000
Z63.7 Other stressful life events affecting family and household
0.004 0.996 0.000
S05.6 Penetrating wound of eyeball without foreign body
0.004 0.996 0.000
S19.9 Unspecified injury of neck
0.000 0.996 0.004
M22.8 Other disorders of patella
0.000 0.996 0.004
K51.2 Ulcerative (chronic) proctitis
0.000 0.996 0.004
M54.96 Dorsalgia, unspecified (Lumbar region)
0.004 0.996 0.000
S05.1 Contusion of eyeball and orbital tissues
0.004 0.996 0.000
M22.4 Chondromalacia patellae
0.000 0.996 0.004
Z63 Other problems related to primary support group, including family circumstances
0.004 0.996 0.000
C45.0 Mesothelioma of pleura
0.000 0.996 0.004
M80.00 Postmenopausal osteoporosis with pathological fracture (Multiple sites)
0.000 0.996 0.004
S05.4 Penetrating wound of orbit with or without foreign body
0.004 0.996 0.000
R80 Isolated proteinuria
0.004 0.996 0.000
S05.5 Penetrating wound of eyeball with foreign body
0.004 0.996 0.000
G61.0 Guillain-Barre syndrome
0.004 0.996 0.000
L73.2 Hidradenitis suppurativa
0.000 0.996 0.004
S05.7 Avulsion of eye
0.004 0.996 0.000
S05.8 Other injuries of eye and orbit
0.004 0.996 0.000
Z63.6 Dependent relative needing care at home
0.003 0.996 0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.004 0.996 0.000
M22.9 Disorder of patella, unspecified
0.000 0.996 0.003
S05.3 Ocular laceration without prolapse or loss of intraocular tissue
0.003 0.997 0.000
E70-E90 Metabolic disorders
0.000 0.997 0.003
S05.2 Ocular laceration and rupture with prolapse or loss of intraocular tissue
0.003 0.997 0.000
M22 Disorders of patella
0.000 0.997 0.003
Z63.5 Disruption of family by separation and divorce
0.003 0.997 0.000
C15.5 Lower third of oesophagus
0.000 0.997 0.003
Z63.4 Disappearance and death of family member
0.003 0.997 0.000
S72.30 Fracture of shaft of femur (closed)
0.003 0.997 0.000
Z63.9 Problem related to primary support group, unspecified
0.003 0.997 0.000
Z63.3 Absence of family member
0.003 0.997 0.000
Z63.2 Inadequate family support
0.003 0.997 0.000
Z63.1 Problems in relationship with parents and in-laws
0.003 0.997 0.000
C45 Mesothelioma
0.000 0.997 0.003
N45.9 Orchitis, epididymitis and epididymo-orchitis without abscess
0.000 0.997 0.003
F10.3 Withdrawal state
0.003 0.997 0.000
C45.9 Mesothelioma, unspecified
0.000 0.997 0.003
S91.1 Open wound of toe(s) without damage to nail
0.000 0.997 0.003
M54.94 Dorsalgia, unspecified (Thoracic region)
0.003 0.997 0.000
D80-D89 Certain disorders involving the immune mechanism
0.003 0.997 0.000
F80.1 Expressive language disorder
0.003 0.997 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.997 0.003
E84 Cystic fibrosis
0.000 0.997 0.003
M54.9 Dorsalgia, unspecified
0.003 0.997 0.000
E85 Amyloidosis
0.000 0.997 0.003
E70 Disorders of aromatic amino-acid metabolism
0.000 0.997 0.003
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.003 0.997 0.000
K46.9 Unspecified abdominal hernia without obstruction or gangrene
0.003 0.997 0.000
M54.97 Dorsalgia, unspecified (Lumbosacral region)
0.003 0.997 0.000
C45.7 Mesothelioma of other sites
0.000 0.997 0.003
H52.3 Anisometropia and aniseikonia
0.000 0.997 0.003
E77 Disorders of glycoprotein metabolism
0.000 0.997 0.003
E76 Disorders of glycosaminoglycan metabolism
0.000 0.997 0.003
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.997 0.003
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.997 0.003
O30.0 Twin pregnancy
0.000 0.997 0.003
M22.1 Recurrent subluxation of patella
0.000 0.997 0.003
S01.3 Open wound of ear
0.003 0.997 0.000
D82 Immunodeficiency associated with other major defects
0.003 0.997 0.000
M80.50 Idiopathic osteoporosis with pathological fracture (Multiple sites)
0.000 0.997 0.003
E72 Other disorders of amino-acid metabolism
0.000 0.997 0.003
M06.0 Seronegative rheumatoid arthritis
0.003 0.997 0.000
E79 Disorders of purine and pyrimidine metabolism
0.000 0.997 0.003
K11.8 Other diseases of salivary glands
0.003 0.997 0.000
C45.2 Mesothelioma of pericardium
0.000 0.997 0.002
C45.1 Mesothelioma of peritoneum
0.000 0.997 0.002
K80.5 Calculus of bile duct without cholangitis or cholecystitis
0.003 0.997 0.000
M22.0 Recurrent dislocation of patella
0.000 0.997 0.002
E75.5 Other lipid storage disorders
0.000 0.997 0.002
S65.1 Injury of radial artery at wrist and hand level
0.003 0.997 0.000
E84.9 Cystic fibrosis, unspecified
0.000 0.997 0.002
E85.3 Secondary systemic amyloidosis
0.000 0.997 0.002
K76.9 Liver disease, unspecified
0.000 0.997 0.003
E74 Other disorders of carbohydrate metabolism
0.000 0.997 0.002
E85.8 Other amyloidosis
0.000 0.997 0.002
M80.0 Postmenopausal osteoporosis with pathological fracture
0.000 0.997 0.002
M22.3 Other derangements of patella
0.000 0.998 0.002
E70.3 Albinism
0.000 0.998 0.002
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.002 0.998 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.002 0.998 0.000
D84 Other immunodeficiencies
0.002 0.998 0.000
D81 Combined immunodeficiencies
0.002 0.998 0.000
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)
0.002 0.998 0.000
M54.95 Dorsalgia, unspecified (Thoracolumbar region)
0.002 0.998 0.000
M62.88 Other specified disorders of muscle (Other)
0.000 0.998 0.002
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.002 0.998 0.000
D82.1 Di George's syndrome
0.002 0.998 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.002 0.998 0.000
E75.6 Lipid storage disorder, unspecified
0.000 0.998 0.002
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.998 0.002
E75.3 Sphingolipidosis, unspecified
0.000 0.998 0.002
E75.2 Other sphingolipidosis
0.000 0.998 0.002
E75.1 Other gangliosidosis
0.000 0.998 0.002
E75.0 GM2 gangliosidosis
0.000 0.998 0.002
M54.93 Dorsalgia, unspecified (Cervicothoracic region)
0.002 0.998 0.000
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)
0.002 0.998 0.000
E84.8 Cystic fibrosis with other manifestations
0.000 0.998 0.002
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.998 0.002
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.998 0.002
E85.4 Organ-limited amyloidosis
0.000 0.998 0.002
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.998 0.002
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.998 0.002
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.998 0.002
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.002 0.998 0.000
S62.20 Fracture of first metacarpal bone (closed)
0.002 0.998 0.000
D05.1 Intraductal carcinoma in situ
0.000 0.998 0.002
D29.0 Penis
0.002 0.998 0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.998 0.002
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.998 0.002
E70.2 Disorders of tyrosine metabolism
0.000 0.998 0.002
E70.1 Other hyperphenylalaninaemias
0.000 0.998 0.002
E70.0 Classical phenylketonuria
0.000 0.998 0.002
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.002 0.998 0.000
L73.9 Follicular disorder, unspecified
0.000 0.998 0.002
M54.92 Dorsalgia, unspecified (Cervical region)
0.002 0.998 0.000
D84.8 Other specified immunodeficiencies
0.002 0.998 0.000
L73 Other follicular disorders
0.000 0.998 0.002
D80 Immunodeficiency with predominantly antibody defects
0.002 0.998 0.000
E88 Other metabolic disorders
0.000 0.998 0.002
I11 Hypertensive heart disease
0.000 0.998 0.002
M54.17 Radiculopathy (Lumbosacral region)
0.002 0.998 0.000
M54.14 Radiculopathy (Thoracic region)
0.002 0.998 0.000
M54.18 Radiculopathy (Sacral and sacrococcygeal region)
0.002 0.998 0.000
K44.0 Diaphragmatic hernia with obstruction, without gangrene
0.002 0.998 0.000
S51.8 Open wound of other parts of forearm
0.000 0.998 0.002
E71.3 Disorders of fatty-acid metabolism
0.000 0.998 0.002
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.998 0.002
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.998 0.002
E71.0 Maple-syrup-urine disease
0.000 0.998 0.002
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.998 0.002
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.998 0.002
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.998 0.002
E76.2 Other mucopolysaccharidoses
0.000 0.998 0.002
E76.1 Mucopolysaccharidosis, type II
0.000 0.998 0.002
E76.0 Mucopolysaccharidosis, type I
0.000 0.998 0.002
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.998 0.002
E77.8 Other disorders of glycoprotein metabolism
0.000 0.998 0.002
E77.1 Defects in glycoprotein degradation
0.000 0.998 0.002
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.998 0.002
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.000 0.998 0.002
M22.10 Recurrent subluxation of patella, unspecified knee
0.000 0.998 0.002
D82.9 Immunodeficiency associated with major defect, unspecified
0.002 0.998 0.000
D82.8 Immunodeficiency associated with other specified major defects
0.002 0.998 0.000
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.002 0.998 0.000
D82.2 Immunodeficiency with short-limbed stature
0.002 0.998 0.000
D82.0 Wiskott-Aldrich syndrome
0.002 0.998 0.000
H26.2 Complicated cataract
0.000 0.998 0.002
T92.1 Sequelae of fracture of arm
0.000 0.998 0.002
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.998 0.002
G61 Inflammatory polyneuropathy
0.002 0.998 0.000
M54.1 Radiculopathy
0.002 0.998 0.000
E73 Lactose intolerance
0.000 0.998 0.002
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.998 0.002
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.998 0.002
E72.5 Disorders of glycine metabolism
0.000 0.998 0.002
E72.4 Disorders of ornithine metabolism
0.000 0.998 0.002
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.998 0.002
E72.2 Disorders of urea cycle metabolism
0.000 0.998 0.002
M06.08 Seronegative rheumatoid arthritis (Other)
0.002 0.998 0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.002 0.998 0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.002 0.998 0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.002 0.998 0.000
E72.0 Disorders of amino-acid transport
0.000 0.998 0.002
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.998 0.002
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.998 0.002
E79.1 Lesch-Nyhan syndrome
0.000 0.998 0.002
F80 Specific developmental disorders of speech and language
0.002 0.998 0.000
S65.5 Injury of blood vessel(s) of other finger
0.002 0.998 0.000
M54.64 Pain in thoracic spine (Thoracic region)
0.002 0.998 0.000
O14.1 Severe preeclampsia
0.000 0.998 0.002
F84.0 Childhood autism
0.002 0.998 0.000
D83 Common variable immunodeficiency
0.002 0.998 0.000
M06.04 Seronegative rheumatoid arthritis (Hand)
0.002 0.998 0.000
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.000 0.998 0.002
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.998 0.002
E74.0 Glycogen storage disease
0.000 0.998 0.002
S60.8 Other superficial injuries of wrist and hand
0.002 0.998 0.000
Z63.0 Problems in relationship with spouse or partner
0.002 0.998 0.000
M54.90 Dorsalgia, unspecified (Multiple sites in spine)
0.002 0.998 0.000
M62.80 Other specified disorders of muscle (Multiple sites)
0.000 0.998 0.002
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.002 0.998 0.000
M80.09 Postmenopausal osteoporosis with pathological fracture (Site unspecified)
0.000 0.998 0.002
M80.08 Postmenopausal osteoporosis with pathological fracture (Other)
0.000 0.998 0.002
M80.07 Postmenopausal osteoporosis with pathological fracture (Ankle and foot)
0.000 0.998 0.002
M80.06 Postmenopausal osteoporosis with pathological fracture (Lower leg)
0.000 0.998 0.002
M80.05 Postmenopausal osteoporosis with pathological fracture (Pelvic region and thigh)
0.000 0.998 0.002
M80.04 Postmenopausal osteoporosis with pathological fracture (Hand)
0.000 0.998 0.002
M80.03 Postmenopausal osteoporosis with pathological fracture (Forearm)
0.000 0.998 0.002

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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