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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3764023
log Bayes Factor = 6.6728
Chromosome 12   position 9,801,382  (GRCh37) Explore rs3764023 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.136 0.864
E10 Insulin-dependent diabetes mellitus
0.000 0.137 0.863
E10.5 With peripheral circulatory complications
0.000 0.157 0.843
E03 Other hypothyroidism
0.000 0.170 0.830
E10.8 With unspecified complications
0.000 0.215 0.785
E00-E07 Disorders of thyroid gland
0.000 0.218 0.782
E10-E14 Diabetes mellitus
0.000 0.246 0.754
E10.2 With renal complications
0.000 0.250 0.750
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.253 0.747
E06 Thyroiditis
0.000 0.255 0.745
E10.4 With neurological complications
0.000 0.274 0.726
E06.3 Autoimmune thyroiditis
0.000 0.274 0.726
E20-E35 Disorders of other endocrine glands
0.000 0.333 0.667
E10.9 Without complications
0.000 0.375 0.625
E29 Testicular dysfunction
0.000 0.378 0.622
E10.7 With multiple complications
0.000 0.381 0.619
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.400 0.600
E29.1 Testicular hypofunction
0.000 0.403 0.597
E03.5 Myxoedema coma
0.000 0.405 0.595
E03.4 Atrophy of thyroid (acquired)
0.000 0.405 0.595
E03.3 Postinfectious hypothyroidism
0.000 0.405 0.595
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.405 0.595
E07 Other disorders of thyroid
0.000 0.411 0.589
E28 Ovarian dysfunction
0.000 0.419 0.581
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.430 0.570
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.439 0.561
E00 Congenital iodine-deficiency syndrome
0.000 0.439 0.561
E24 Cushing's syndrome
0.000 0.446 0.554
E12 Malnutrition-related diabetes mellitus
0.000 0.459 0.541
E34 Other endocrine disorders
0.000 0.462 0.538
E40-E46 Malnutrition
0.000 0.466 0.534
E06.4 Drug-induced thyroiditis
0.000 0.466 0.534
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.466 0.534
E06.1 Subacute thyroiditis
0.000 0.466 0.534
E06.0 Acute thyroiditis
0.000 0.466 0.534
E10.6 With other specified complications
0.000 0.472 0.528
E10.0 With coma
0.000 0.477 0.523
E03.1 Congenital hypothyroidism without goitre
0.000 0.478 0.522
E22 Hyperfunction of pituitary gland
0.000 0.482 0.518
E65-E68 Obesity and other hyperalimentation
0.000 0.486 0.514
E07.8 Other specified disorders of thyroid
0.000 0.487 0.513
E06.5 Other chronic thyroiditis
0.000 0.487 0.512
E24.9 Cushing's syndrome, unspecified
0.000 0.489 0.511
E28.3 Primary ovarian failure
0.000 0.498 0.502
E06.9 Thyroiditis, unspecified
0.000 0.517 0.483
E25 Adrenogenital disorders
0.000 0.519 0.481
E27 Other disorders of adrenal gland
0.000 0.521 0.479
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.521 0.478
E32 Diseases of thymus
0.000 0.521 0.478
E30 Disorders of puberty, not elsewhere classified
0.000 0.521 0.478
E34.9 Endocrine disorder, unspecified
0.000 0.522 0.478
E20 Hypoparathyroidism
0.000 0.537 0.462
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.545 0.455
E28.2 Polycystic ovarian syndrome
0.000 0.546 0.454
E29.8 Other testicular dysfunction
0.000 0.554 0.446
E29.0 Testicular hyperfunction
0.000 0.554 0.446
E31 Polyglandular dysfunction
0.000 0.556 0.444
E13 Other specified diabetes mellitus
0.000 0.558 0.441
E27.9 Disorder of adrenal gland, unspecified
0.000 0.564 0.436
E07.1 Dyshormogenetic goitre
0.000 0.578 0.422
E07.0 Hypersecretion of calcitonin
0.000 0.578 0.422
E28.9 Ovarian dysfunction, unspecified
0.000 0.583 0.417
E28.8 Other ovarian dysfunction
0.000 0.583 0.417
E28.1 Androgen excess
0.000 0.583 0.417
E28.0 Oestrogen excess
0.000 0.583 0.417
E26 Hyperaldosteronism
0.000 0.595 0.405
E10.1 With ketoacidosis
0.000 0.596 0.404
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.598 0.402
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.598 0.402
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.598 0.402
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.598 0.402
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.598 0.402
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.598 0.402
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.598 0.402
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.598 0.402
E22.0 Acromegaly and pituitary gigantism
0.000 0.599 0.401
E22.1 Hyperprolactinaemia
0.000 0.600 0.400
E29.9 Testicular dysfunction, unspecified
0.000 0.603 0.397
E24.8 Other Cushing's syndrome
0.000 0.603 0.397
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.603 0.397
E24.3 Ectopic ACTH syndrome
0.000 0.603 0.397
E24.1 Nelson's syndrome
0.000 0.603 0.397
E24.0 Pituitary-dependent Cushing's disease
0.000 0.603 0.397
E34.8 Other specified endocrine disorders
0.000 0.605 0.395
E12.9 Without complications
0.000 0.612 0.388
E12.8 With unspecified complications
0.000 0.612 0.388
E12.7 With multiple complications
0.000 0.612 0.388
E12.6 With other specified complications
0.000 0.612 0.388
E12.5 With peripheral circulatory complications
0.000 0.612 0.388
E12.4 With neurological complications
0.000 0.612 0.388
E12.3 With ophthalmic complications
0.000 0.612 0.388
E12.2 With renal complications
0.000 0.612 0.388
E12.1 With ketoacidosis
0.000 0.612 0.388
E12.0 With coma
0.000 0.612 0.388
E34.5 Androgen resistance syndrome
0.000 0.614 0.386
E34.4 Constitutional tall stature
0.000 0.614 0.386
E34.3 Short stature, not elsewhere classified
0.000 0.614 0.386
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.614 0.386
E34.1 Other hypersecretion of intestinal hormones
0.000 0.614 0.386
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.617 0.383
E45 Retarded development following protein-energy malnutrition
0.000 0.617 0.383
E43 Unspecified severe protein-energy malnutrition
0.000 0.617 0.383
E42 Marasmic kwashiorkor
0.000 0.617 0.383
E41 Nutritional marasmus
0.000 0.617 0.383
E40 Kwashiorkor
0.000 0.617 0.383
E46 Unspecified protein-energy malnutrition
0.000 0.618 0.382
E27.1 Primary adrenocortical insufficiency
0.000 0.623 0.377
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.629 0.371
E22.8 Other hyperfunction of pituitary gland
0.000 0.629 0.371
E67 Other hyperalimentation
0.000 0.631 0.369
E68 Sequelae of hyperalimentation
0.000 0.631 0.369
E66 Obesity
0.000 0.633 0.367
E23 Hypofunction and other disorders of pituitary gland
0.000 0.636 0.364
E03.8 Other specified hypothyroidism
0.001 0.636 0.364
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.650 0.350
E65 Localised adiposity
0.000 0.651 0.349
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.652 0.348
E25.9 Adrenogenital disorder, unspecified
0.000 0.655 0.345
E25.8 Other adrenogenital disorders
0.000 0.655 0.345
E27.2 Addisonian crisis
0.000 0.656 0.344
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.656 0.343
E27.5 Adrenomedullary hyperfunction
0.000 0.656 0.343
E27.0 Other adrenocortical overactivity
0.000 0.656 0.343
E30.9 Disorder of puberty, unspecified
0.000 0.657 0.343
E30.8 Other disorders of puberty
0.000 0.657 0.343
E30.1 Precocious puberty
0.000 0.657 0.343
E30.0 Delayed puberty
0.000 0.657 0.343
E32.9 Disease of thymus, unspecified
0.000 0.657 0.343
E32.8 Other diseases of thymus
0.000 0.657 0.343
E32.1 Abscess of thymus
0.000 0.657 0.343
E32.0 Persistent hyperplasia of thymus
0.000 0.657 0.343
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.657 0.343
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.657 0.343
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.657 0.343
E14 Unspecified diabetes mellitus
0.000 0.660 0.340
E20.8 Other hypoparathyroidism
0.000 0.668 0.332
E20.1 Pseudohypoparathyroidism
0.000 0.668 0.332
E20.0 Idiopathic hypoparathyroidism
0.000 0.668 0.332
E15 Nondiabetic hypoglycaemic coma
0.000 0.673 0.326
E31.9 Polyglandular dysfunction, unspecified
0.000 0.681 0.318
E31.8 Other polyglandular dysfunction
0.000 0.681 0.318
E31.1 Polyglandular hyperfunction
0.000 0.681 0.318
E13.8 With unspecified complications
0.000 0.683 0.317
E13.7 With multiple complications
0.000 0.683 0.317
E13.6 With other specified complications
0.000 0.683 0.317
E13.5 With peripheral circulatory complications
0.000 0.683 0.317
E13.4 With neurological complications
0.000 0.683 0.317
E13.2 With renal complications
0.000 0.683 0.317
E13.1 With ketoacidosis
0.000 0.683 0.317
E13.0 With coma
0.000 0.683 0.317
E20.9 Hypoparathyroidism, unspecified
0.000 0.684 0.316
E13.3 With ophthalmic complications
0.000 0.690 0.310
E66.0 Obesity due to excess calories
0.000 0.693 0.307
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.704 0.295
E66.8 Other obesity
0.000 0.706 0.294
E23.2 Diabetes insipidus
0.000 0.706 0.294
E26.8 Other hyperaldosteronism
0.000 0.709 0.290
E26.1 Secondary hyperaldosteronism
0.000 0.709 0.290
E34.0 Carcinoid syndrome
0.000 0.712 0.287
E07.9 Disorder of thyroid, unspecified
0.000 0.714 0.286
E26.9 Hyperaldosteronism, unspecified
0.000 0.714 0.286
E31.0 Autoimmune polyglandular failure
0.000 0.716 0.284
E44.1 Mild protein-energy malnutrition
0.000 0.725 0.275
E44.0 Moderate protein-energy malnutrition
0.000 0.725 0.275
E27.8 Other specified disorders of adrenal gland
0.000 0.726 0.274
E67.8 Other specified hyperalimentation
0.000 0.735 0.264
E67.3 Hypervitaminosis D
0.000 0.735 0.264
E67.2 Megavitamin-B6 syndrome
0.000 0.735 0.264
E67.1 Hypercarotenaemia
0.000 0.735 0.264
E67.0 Hypervitaminosis A
0.000 0.735 0.264
E66.1 Drug-induced obesity
0.000 0.737 0.263
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.739 0.261
E23.1 Drug-induced hypopituitarism
0.000 0.739 0.261
E14.1 With ketoacidosis
0.000 0.742 0.258
E14.6 With other specified complications
0.000 0.743 0.257
E24.2 Drug-induced Cushing's syndrome
0.001 0.744 0.255
E14.2 Withrenal complications
0.000 0.749 0.251
E16 Other disorders of pancreatic internal secretion
0.000 0.754 0.246
E14.7 With multiple complications
0.000 0.756 0.244
E14.0 With coma
0.000 0.756 0.244
E05.9 Thyrotoxicosis, unspecified
0.000 0.759 0.241
E14.3 With ophthalmic complications
0.000 0.762 0.238
E14.8 With unspecified complications
0.000 0.765 0.235
E13.9 Without complications
0.000 0.772 0.228
E23.6 Other disorders of pituitary gland
0.000 0.774 0.226
E26.0 Primary hyperaldosteronism
0.000 0.776 0.224
E14.5 With peripheral circulatory complications
0.000 0.778 0.222
E23.0 Hypopituitarism
0.000 0.783 0.217
E05.5 Thyroid crisis or storm
0.000 0.788 0.212
E05.4 Thyrotoxicosis factitia
0.000 0.788 0.212
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.788 0.212
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.788 0.212
E66.9 Obesity, unspecified
0.000 0.792 0.208
E05.8 Other thyrotoxicosis
0.000 0.798 0.202
E23.7 Disorder of pituitary gland, unspecified
0.000 0.800 0.199
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.803 0.197
E50-E64 Other nutritional deficiencies
0.000 0.822 0.178
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.823 0.176
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.823 0.176
E16.4 Abnormal secretion of gastrin
0.000 0.823 0.176
E16.3 Increased secretion of glucagon
0.000 0.823 0.176
E16.1 Other hypoglycaemia
0.000 0.827 0.173
E14.9 Without complications
0.000 0.828 0.172
E14.4 With neurological complications
0.000 0.831 0.169
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.847 0.153
E16.2 Hypoglycaemia, unspecified
0.000 0.861 0.139
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.872 0.128
E63 Other nutritional deficiencies
0.000 0.872 0.128
E50 Vitamin A deficiency
0.000 0.872 0.128
E60 Dietary zinc deficiency
0.000 0.872 0.128
E59 Dietary selenium deficiency
0.000 0.872 0.128
E54 Ascorbic acid deficiency
0.000 0.872 0.128
E52 Niacin deficiency [pellagra]
0.000 0.872 0.128
E56 Other vitamin deficiencies
0.000 0.886 0.114
E51 Thiamine deficiency
0.000 0.887 0.113
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.887 0.113
E53 Deficiency of other B group vitamins
0.000 0.889 0.111
E58 Dietary calcium deficiency
0.000 0.892 0.107
E61 Deficiency of other nutrient elements
0.000 0.895 0.105
E27.4 Other and unspecified adrenocortical insufficiency
0.001 0.895 0.104
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.903 0.096
E04 Other non-toxic goitre
0.000 0.907 0.093
E50.9 Vitamin A deficiency, unspecified
0.000 0.908 0.092
E50.8 Other manifestations of vitamin A deficiency
0.000 0.908 0.092
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.908 0.092
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.908 0.092
E50.5 Vitamin A deficiency with night blindness
0.000 0.908 0.092
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.908 0.092
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.908 0.092
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.908 0.092
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.908 0.092
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.908 0.092
E63.9 Nutritional deficiency, unspecified
0.000 0.908 0.092
E63.8 Other specified nutritional deficiencies
0.000 0.908 0.092
E63.1 Imbalance of constituents of food intake
0.000 0.908 0.092
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.908 0.092
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.908 0.092
E64.8 Sequelae of other nutritional deficiencies
0.000 0.908 0.092
E64.3 Sequelae of rickets
0.000 0.908 0.092
E64.2 Sequelae of vitamin C deficiency
0.000 0.908 0.092
E64.1 Sequelae of vitamin A deficiency
0.000 0.908 0.092
E64.0 Sequelae of protein-energy malnutrition
0.000 0.908 0.092
E53.9 Vitamin B deficiency, unspecified
0.000 0.909 0.091
E55 Vitamin D deficiency
0.000 0.914 0.085
E56.9 Vitamin deficiency, unspecified
0.000 0.918 0.082
E56.8 Deficiency of other vitamins
0.000 0.918 0.082
E56.0 Deficiency of vitamin E
0.000 0.918 0.082
E51.9 Thiamine deficiency, unspecified
0.000 0.918 0.081
E51.8 Other manifestations of thiamine deficiency
0.000 0.918 0.081
E51.1 Beriberi
0.000 0.918 0.081
E53.1 Pyridoxine deficiency
0.000 0.920 0.080
E53.0 Riboflavin deficiency
0.000 0.920 0.080
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.920 0.079
E61.9 Deficiency of nutrient element, unspecified
0.000 0.924 0.075
E61.8 Deficiency of other specified nutrient elements
0.000 0.924 0.075
E61.7 Deficiency of multiple nutrient elements
0.000 0.924 0.075
E61.6 Vanadium deficiency
0.000 0.924 0.075
E61.5 Molybdenum deficiency
0.000 0.924 0.075
E61.4 Chromium deficiency
0.000 0.924 0.075
E61.3 Manganese deficiency
0.000 0.924 0.075
E61.0 Copper deficiency
0.000 0.924 0.075
E21.2 Other hyperparathyroidism
0.000 0.929 0.071
E61.1 Iron deficiency
0.000 0.929 0.071
E21.4 Other specified disorders of parathyroid gland
0.000 0.930 0.069
E56.1 Deficiency of vitamin K
0.001 0.931 0.068
E04.8 Other specified non-toxic goitre
0.000 0.933 0.067
E51.2 Wernicke's encephalopathy
0.001 0.933 0.067
E04.0 Non-toxic diffuse goitre
0.000 0.935 0.064
E55.0 Rickets, active
0.000 0.938 0.061
E61.2 Magnesium deficiency
0.000 0.940 0.060
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.001 0.946 0.054
E21.5 Disorder of parathyroid gland, unspecified
0.001 0.948 0.051
M89.97 Disorder of bone, unspecified (Ankle and foot)
0.038 0.962 0.000
E21.0 Primary hyperparathyroidism
0.000 0.963 0.037
E53.8 Deficiency of other specified B group vitamins
0.000 0.964 0.036
E04.2 Non-toxic multinodular goitre
0.000 0.964 0.036
E11 Non-insulin-dependent diabetes mellitus
0.000 0.967 0.033
M89.9 Disorder of bone, unspecified
0.029 0.971 0.000
E11.1 With ketoacidosis
0.000 0.974 0.026
E11.8 With unspecified complications
0.000 0.976 0.024
E11.7 With multiple complications
0.000 0.976 0.024
M89.92 Disorder of bone, unspecified (Upper arm)
0.024 0.976 0.000
M89.90 Disorder of bone, unspecified (Multiple sites)
0.023 0.976 0.000
M89.93 Disorder of bone, unspecified (Forearm)
0.023 0.976 0.000
F31.0 Bipolar affective disorder, current episode hypomanic
0.000 0.978 0.022
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms
0.000 0.978 0.022
M89.98 Disorder of bone, unspecified (Other)
0.022 0.978 0.000
F31 Bipolar affective disorder
0.000 0.978 0.022
E04.9 Non-toxic goitre, unspecified
0.000 0.979 0.021
M89.94 Disorder of bone, unspecified (Hand)
0.021 0.979 0.000
M89.99 Disorder of bone, unspecified (Site unspecified)
0.021 0.979 0.000
M89.91 Disorder of bone, unspecified (Shoulder region)
0.021 0.979 0.000
M89.96 Disorder of bone, unspecified (Lower leg)
0.021 0.979 0.000
M89.95 Disorder of bone, unspecified (Pelvic region and thigh)
0.021 0.979 0.000
E11.4 With neurological complications
0.000 0.979 0.021
E11.6 With other specified complications
0.000 0.979 0.020
K22.4 Dyskinesia of oesophagus
0.020 0.980 0.000
E21.3 Hyperparathyroidism, unspecified
0.001 0.980 0.020
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.000 0.980 0.019
E55.9 Vitamin D deficiency, unspecified
0.000 0.981 0.019
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms
0.000 0.981 0.019
E11.5 With peripheral circulatory complications
0.000 0.982 0.018
E04.1 Non-toxic single thyroid nodule
0.000 0.982 0.018
R63.0 Anorexia
0.018 0.982 0.000
F31.7 Bipolar affective disorder, currently in remission
0.000 0.983 0.017
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.000 0.983 0.017
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms
0.000 0.984 0.016
E11.3 With ophthalmic complications
0.000 0.984 0.016
E11.0 With coma
0.000 0.984 0.016
K60.1 Chronic anal fissure
0.015 0.985 0.000
F31.6 Bipolar affective disorder, current episode mixed
0.000 0.985 0.014
K22.5 Diverticulum of oesophagus, acquired
0.014 0.986 0.000
F31.8 Other bipolar affective disorders
0.000 0.987 0.013
K60.3 Anal fistula
0.013 0.987 0.000
E85 Amyloidosis
0.000 0.988 0.012
E85.4 Organ-limited amyloidosis
0.000 0.988 0.012
K60 Fissure and fistula of anal and rectal regions
0.012 0.988 0.000
E70-E90 Metabolic disorders
0.000 0.988 0.012
K22 Other diseases of oesophagus
0.012 0.988 0.000
K60.0 Acute anal fissure
0.011 0.989 0.000
F31.9 Bipolar affective disorder, unspecified
0.000 0.989 0.011
K22.3 Perforation of oesophagus
0.011 0.989 0.000
K22.6 Gastro-oesophageal laceration-haemorrhage syndrome
0.011 0.989 0.000
E85.9 Amyloidosis, unspecified
0.000 0.990 0.010
E88 Other metabolic disorders
0.000 0.990 0.010
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.990 0.010
E85.3 Secondary systemic amyloidosis
0.000 0.990 0.010
K22.1 Ulcer of oesophagus
0.009 0.991 0.000
K60.5 Anorectal fistula
0.009 0.991 0.000
E85.8 Other amyloidosis
0.000 0.991 0.009
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.991 0.009
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.991 0.009
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.991 0.009
E79 Disorders of purine and pyrimidine metabolism
0.000 0.991 0.009
E84 Cystic fibrosis
0.000 0.991 0.009
E11.2 With renal complications
0.000 0.991 0.008
E77 Disorders of glycoprotein metabolism
0.000 0.991 0.009
E76 Disorders of glycosaminoglycan metabolism
0.000 0.991 0.009
E72 Other disorders of amino-acid metabolism
0.000 0.991 0.009
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.991 0.009
E70 Disorders of aromatic amino-acid metabolism
0.000 0.991 0.009
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.991 0.009
M89 Other disorders of bone
0.008 0.992 0.000
Z63.7 Other stressful life events affecting family and household
0.008 0.992 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.992 0.008
E88.9 Metabolic disorder, unspecified
0.000 0.992 0.008
K22.0 Achalasia of cardia
0.008 0.992 0.000
E88.2 Lipomatosis, not elsewhere classified
0.000 0.992 0.007
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.993 0.007
K60.4 Rectal fistula
0.007 0.993 0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.993 0.007
J34.2 Deviated nasal septum
0.000 0.993 0.007
E88.3 Tumour lysis syndrome
0.000 0.993 0.007
E74 Other disorders of carbohydrate metabolism
0.000 0.993 0.006
M89.5 Osteolysis
0.007 0.993 0.000
E84.9 Cystic fibrosis, unspecified
0.000 0.993 0.007
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.993 0.007
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.993 0.007
E79.1 Lesch-Nyhan syndrome
0.000 0.993 0.007
E84.8 Cystic fibrosis with other manifestations
0.000 0.993 0.006
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.993 0.006
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.993 0.006
E73 Lactose intolerance
0.000 0.993 0.006
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.993 0.006
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.993 0.006
E70.3 Albinism
0.000 0.993 0.006
E70.2 Disorders of tyrosine metabolism
0.000 0.993 0.006
E70.1 Other hyperphenylalaninaemias
0.000 0.993 0.006
E70.0 Classical phenylketonuria
0.000 0.993 0.006
E71.3 Disorders of fatty-acid metabolism
0.000 0.993 0.006
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.993 0.006
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.993 0.006
E71.0 Maple-syrup-urine disease
0.000 0.993 0.006
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.993 0.006
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.993 0.006
E72.5 Disorders of glycine metabolism
0.000 0.993 0.006
E72.4 Disorders of ornithine metabolism
0.000 0.993 0.006
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.993 0.006
E72.2 Disorders of urea cycle metabolism
0.000 0.993 0.006
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.993 0.006
E72.0 Disorders of amino-acid transport
0.000 0.993 0.006
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.993 0.006
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.993 0.006
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.993 0.006
E76.2 Other mucopolysaccharidoses
0.000 0.993 0.006
E76.1 Mucopolysaccharidosis, type II
0.000 0.993 0.006
E76.0 Mucopolysaccharidosis, type I
0.000 0.993 0.006
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.993 0.006
E77.8 Other disorders of glycoprotein metabolism
0.000 0.993 0.006
E77.1 Defects in glycoprotein degradation
0.000 0.993 0.006
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.993 0.006
M89.6 Osteopathy after poliomyelitis
0.006 0.994 0.000
M89.4 Other hypertrophic osteo-arthropathy
0.006 0.994 0.000
M89.2 Other disorders of bone development and growth
0.006 0.994 0.000
M89.1 Epiphyseal arrest
0.006 0.994 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.994 0.006
E75.6 Lipid storage disorder, unspecified
0.000 0.994 0.006
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.994 0.006
E75.3 Sphingolipidosis, unspecified
0.000 0.994 0.006
E75.2 Other sphingolipidosis
0.000 0.994 0.006
E75.1 Other gangliosidosis
0.000 0.994 0.006
E75.0 GM2 gangliosidosis
0.000 0.994 0.006
E88.8 Other specified metabolic disorders
0.000 0.994 0.006
M89.3 Hypertrophy of bone
0.006 0.994 0.000
M89.55 Osteolysis (Pelvic region and thigh)
0.006 0.994 0.000
J34.1 Cyst and mucocele of nose and nasal sinus
0.000 0.994 0.006
Z63 Other problems related to primary support group, including family circumstances
0.005 0.994 0.000
E75.5 Other lipid storage disorders
0.000 0.995 0.005
F30 Manic episode
0.000 0.995 0.005
F30-F39 Mood [affective] disorders
0.000 0.995 0.005
R73.9 Hyperglycaemia, unspecified
0.005 0.995 0.000
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.995 0.005
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.995 0.005
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.995 0.005
E74.2 Disorders of galactose metabolism
0.000 0.995 0.005
E74.1 Disorders of fructose metabolism
0.000 0.995 0.005
E74.0 Glycogen storage disease
0.000 0.995 0.005
Z63.6 Dependent relative needing care at home
0.005 0.995 0.000
M89.8 Other specified disorders of bone
0.005 0.995 0.000
M89.59 Osteolysis (Site unspecified)
0.005 0.995 0.000
M89.58 Osteolysis (Other)
0.005 0.995 0.000
M89.57 Osteolysis (Ankle and foot)
0.005 0.995 0.000
M89.56 Osteolysis (Lower leg)
0.005 0.995 0.000
M89.54 Osteolysis (Hand)
0.005 0.995 0.000
M89.53 Osteolysis (Forearm)
0.005 0.995 0.000
M89.52 Osteolysis (Upper arm)
0.005 0.995 0.000
M89.51 Osteolysis (Shoulder region)
0.005 0.995 0.000
M89.50 Osteolysis (Multiple sites)
0.005 0.995 0.000
N13.1 Hydronephrosis with ureteral stricture, not elsewhere classified
0.000 0.995 0.005
E73.8 Other lactose intolerance
0.000 0.995 0.005
E73.1 Secondary lactase deficiency
0.000 0.995 0.005
E73.0 Congenital lactase deficiency
0.000 0.995 0.005
F30.2 Mania with psychotic symptoms
0.000 0.995 0.005
Z82.3 Family history of stroke
0.000 0.995 0.005
E80.2 Other porphyria
0.000 0.995 0.005
Z63.5 Disruption of family by separation and divorce
0.005 0.995 0.000
F34 Persistent mood [affective] disorders
0.000 0.995 0.005
M89.19 Epiphyseal arrest (Site unspecified)
0.005 0.995 0.000
M89.18 Epiphyseal arrest (Other)
0.005 0.995 0.000
M89.17 Epiphyseal arrest (Ankle and foot)
0.005 0.995 0.000
M89.16 Epiphyseal arrest (Lower leg)
0.005 0.995 0.000
M89.15 Epiphyseal arrest (Pelvic region and thigh)
0.005 0.995 0.000
M89.14 Epiphyseal arrest (Hand)
0.005 0.995 0.000
M89.13 Epiphyseal arrest (Forearm)
0.005 0.995 0.000
M89.12 Epiphyseal arrest (Upper arm)
0.005 0.995 0.000
M89.11 Epiphyseal arrest (Shoulder region)
0.005 0.995 0.000
M89.10 Epiphyseal arrest (Multiple sites)
0.005 0.995 0.000
M89.29 Other disorders of bone development and growth (Site unspecified)
0.005 0.995 0.000
M89.28 Other disorders of bone development and growth (Other)
0.005 0.995 0.000
M89.27 Other disorders of bone development and growth (Ankle and foot)
0.005 0.995 0.000
M89.26 Other disorders of bone development and growth (Lower leg)
0.005 0.995 0.000
M89.25 Other disorders of bone development and growth (Pelvic region and thigh)
0.005 0.995 0.000
M89.24 Other disorders of bone development and growth (Hand)
0.005 0.995 0.000
M89.23 Other disorders of bone development and growth (Forearm)
0.005 0.995 0.000
M89.22 Other disorders of bone development and growth (Upper arm)
0.005 0.995 0.000
M89.21 Other disorders of bone development and growth (Shoulder region)
0.005 0.995 0.000
M89.20 Other disorders of bone development and growth (Multiple sites)
0.005 0.995 0.000
M89.49 Other hypertrophic osteoarthropathy (Site unspecified)
0.005 0.995 0.000
M89.48 Other hypertrophic osteoarthropathy (Other)
0.005 0.995 0.000
M89.47 Other hypertrophic osteoarthropathy (Ankle and foot)
0.005 0.995 0.000
M89.46 Other hypertrophic osteoarthropathy (Lower leg)
0.005 0.995 0.000
M89.45 Other hypertrophic osteoarthropathy (Pelvic region and thigh)
0.005 0.995 0.000
M89.44 Other hypertrophic osteoarthropathy (Hand)
0.005 0.995 0.000
M89.43 Other hypertrophic osteoarthropathy (Forearm)
0.005 0.995 0.000
M89.42 Other hypertrophic osteoarthropathy (Upper arm)
0.005 0.995 0.000
M89.41 Other hypertrophic osteoarthropathy (Shoulder region)
0.005 0.995 0.000
M89.40 Other hypertrophic osteoarthropathy (Multiple sites)
0.005 0.995 0.000
M89.69 Osteopathy after poliomyelitis (Site unspecified)
0.005 0.995 0.000
M89.68 Osteopathy after poliomyelitis (Other)
0.005 0.995 0.000
M89.67 Osteopathy after poliomyelitis (Ankle and foot)
0.005 0.995 0.000
M89.66 Osteopathy after poliomyelitis (Lower leg)
0.005 0.995 0.000
M89.65 Osteopathy after poliomyelitis (Pelvic region and thigh)
0.005 0.995 0.000
M89.64 Osteopathy after poliomyelitis (Hand)
0.005 0.995 0.000
M89.63 Osteopathy after poliomyelitis (Forearm)
0.005 0.995 0.000
M89.62 Osteopathy after poliomyelitis (Upper arm)
0.005 0.995 0.000
M89.61 Osteopathy after poliomyelitis (Shoulder region)
0.005 0.995 0.000
M89.60 Osteopathy after poliomyelitis (Multiple sites)
0.005 0.995 0.000
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.995 0.005
E80.5 Crigler-Najjar syndrome
0.000 0.995 0.005
E80.3 Defects of catalase and peroxydase
0.000 0.995 0.005
E80.0 Hereditary erythropoietic porphyria
0.000 0.995 0.005
F34.1 Dysthymia
0.000 0.995 0.005
Z63.8 Other specified problems related to primary support group
0.005 0.995 0.000
F30.0 Hypomania
0.000 0.995 0.005
Z63.4 Disappearance and death of family member
0.005 0.995 0.000
K22.9 Disease of oesophagus, unspecified
0.005 0.995 0.000
M89.89 Other specified disorders of bone (Site unspecified)
0.004 0.995 0.000
J34 Other disorders of nose and nasal sinuses
0.000 0.995 0.005
F30.9 Manic episode, unspecified
0.000 0.995 0.004
K22.7 Barrett's oesophagus
0.005 0.995 0.000
M89.85 Other specified disorders of bone (Pelvic region and thigh)
0.004 0.996 0.000
M89.39 Hypertrophy of bone (Site unspecified)
0.004 0.996 0.000
M89.36 Hypertrophy of bone (Lower leg)
0.004 0.996 0.000
M89.35 Hypertrophy of bone (Pelvic region and thigh)
0.004 0.996 0.000
M89.34 Hypertrophy of bone (Hand)
0.004 0.996 0.000
M89.33 Hypertrophy of bone (Forearm)
0.004 0.996 0.000
M89.32 Hypertrophy of bone (Upper arm)
0.004 0.996 0.000
M89.31 Hypertrophy of bone (Shoulder region)
0.004 0.996 0.000
M89.30 Hypertrophy of bone (Multiple sites)
0.004 0.996 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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