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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs377392
log Bayes Factor = 52.397
Chromosome 6   position 28,784,741  (GRCh37) Explore rs377392 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
E10.9 Without complications
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.003 0.997
E10-E14 Diabetes mellitus
0.000 0.004 0.996
E16.2 Hypoglycaemia, unspecified
0.000 0.006 0.994
E16 Other disorders of pancreatic internal secretion
0.000 0.006 0.994
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.006 0.994
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.006 0.994
E10.3 With ophthalmic complications
0.000 0.007 0.993
E00-E07 Disorders of thyroid gland
0.000 0.008 0.992
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.052 0.948
E10.2 With renal complications
0.000 0.057 0.943
E10.1 With ketoacidosis
0.000 0.090 0.910
E10.4 With neurological complications
0.000 0.119 0.881
E13 Other specified diabetes mellitus
0.000 0.181 0.819
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.816 0.184 0.000
E05.8 Other thyrotoxicosis
0.000 0.188 0.812
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.213 0.787
E16.1 Other hypoglycaemia
0.000 0.224 0.776
E10.7 With multiple complications
0.000 0.251 0.749
E10.0 With coma
0.000 0.280 0.720
E05.5 Thyroid crisis or storm
0.000 0.285 0.715
E05.4 Thyrotoxicosis factitia
0.000 0.285 0.715
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.285 0.715
E12 Malnutrition-related diabetes mellitus
0.000 0.286 0.714
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.287 0.713
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.287 0.713
E16.4 Abnormal secretion of gastrin
0.000 0.287 0.713
E16.3 Increased secretion of glucagon
0.000 0.287 0.713
E15 Nondiabetic hypoglycaemic coma
0.000 0.287 0.713
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.289 0.711
E00 Congenital iodine-deficiency syndrome
0.000 0.289 0.711
E40-E46 Malnutrition
0.000 0.295 0.705
E13.9 Without complications
0.000 0.309 0.691
E10.6 With other specified complications
0.000 0.333 0.667
E14 Unspecified diabetes mellitus
0.000 0.342 0.658
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.364 0.636
E10.5 With peripheral circulatory complications
0.000 0.386 0.614
E07 Other disorders of thyroid
0.000 0.389 0.611
E13.3 With ophthalmic complications
0.000 0.409 0.591
E13.8 With unspecified complications
0.000 0.412 0.587
E13.7 With multiple complications
0.000 0.412 0.587
E13.6 With other specified complications
0.000 0.412 0.587
E13.5 With peripheral circulatory complications
0.000 0.412 0.587
E13.4 With neurological complications
0.000 0.412 0.587
E13.2 With renal complications
0.000 0.412 0.587
E13.1 With ketoacidosis
0.000 0.412 0.587
E13.0 With coma
0.000 0.412 0.587
E06 Thyroiditis
0.000 0.414 0.586
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.428 0.572
E14.3 With ophthalmic complications
0.000 0.455 0.545
E10.8 With unspecified complications
0.000 0.463 0.536
E14.1 With ketoacidosis
0.000 0.469 0.531
E12.9 Without complications
0.000 0.488 0.512
E12.8 With unspecified complications
0.000 0.488 0.512
E12.7 With multiple complications
0.000 0.488 0.512
E12.6 With other specified complications
0.000 0.488 0.512
E12.5 With peripheral circulatory complications
0.000 0.488 0.512
E12.4 With neurological complications
0.000 0.488 0.512
E12.3 With ophthalmic complications
0.000 0.488 0.512
E12.2 With renal complications
0.000 0.488 0.512
E12.1 With ketoacidosis
0.000 0.488 0.512
E12.0 With coma
0.000 0.488 0.512
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.490 0.510
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.490 0.510
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.490 0.510
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.490 0.510
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.490 0.510
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.490 0.510
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.490 0.510
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.490 0.510
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.494 0.506
E45 Retarded development following protein-energy malnutrition
0.000 0.494 0.506
E43 Unspecified severe protein-energy malnutrition
0.000 0.494 0.506
E42 Marasmic kwashiorkor
0.000 0.494 0.506
E41 Nutritional marasmus
0.000 0.494 0.506
E40 Kwashiorkor
0.000 0.494 0.506
E14.6 With other specified complications
0.000 0.500 0.500
E46 Unspecified protein-energy malnutrition
0.000 0.502 0.498
E14.4 With neurological complications
0.000 0.510 0.489
E07.8 Other specified disorders of thyroid
0.000 0.517 0.483
E14.8 With unspecified complications
0.000 0.523 0.477
E06.9 Thyroiditis, unspecified
0.000 0.527 0.472
E14.7 With multiple complications
0.000 0.528 0.472
E14.2 Withrenal complications
0.000 0.550 0.450
E14.5 With peripheral circulatory complications
0.000 0.555 0.445
E14.0 With coma
0.000 0.558 0.442
E06.1 Subacute thyroiditis
0.000 0.560 0.440
E07.1 Dyshormogenetic goitre
0.000 0.562 0.438
E07.0 Hypersecretion of calcitonin
0.000 0.562 0.438
E06.4 Drug-induced thyroiditis
0.000 0.580 0.420
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.580 0.420
E06.0 Acute thyroiditis
0.000 0.580 0.420
E06.5 Other chronic thyroiditis
0.000 0.597 0.403
K90 Intestinal malabsorption
0.000 0.600 0.400
E03 Other hypothyroidism
0.000 0.600 0.400
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.618 0.382
E44.1 Mild protein-energy malnutrition
0.000 0.637 0.362
E44.0 Moderate protein-energy malnutrition
0.000 0.637 0.362
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.660 0.340
E11 Non-insulin-dependent diabetes mellitus
0.000 0.665 0.335
E65-E68 Obesity and other hyperalimentation
0.000 0.679 0.321
E50-E64 Other nutritional deficiencies
0.000 0.681 0.319
E11.6 With other specified complications
0.000 0.691 0.309
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.701 0.299
E11.1 With ketoacidosis
0.000 0.713 0.287
K90.3 Pancreatic steatorrhoea
0.000 0.713 0.287
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.713 0.287
K90.1 Tropical sprue
0.000 0.713 0.287
E03.5 Myxoedema coma
0.000 0.713 0.287
E03.4 Atrophy of thyroid (acquired)
0.000 0.713 0.287
E03.3 Postinfectious hypothyroidism
0.000 0.713 0.287
E11.0 With coma
0.000 0.723 0.277
E03.1 Congenital hypothyroidism without goitre
0.000 0.724 0.276
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.725 0.275
K90.8 Other intestinal malabsorption
0.000 0.726 0.274
M45.X9 Ankylosing spondylitis (Site unspecified)
0.249 0.751 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.756 0.244
E03.8 Other specified hypothyroidism
0.000 0.757 0.243
E11.2 With renal complications
0.000 0.759 0.241
E11.7 With multiple complications
0.000 0.759 0.241
E54 Ascorbic acid deficiency
0.000 0.768 0.232
E67 Other hyperalimentation
0.000 0.770 0.230
E68 Sequelae of hyperalimentation
0.000 0.770 0.230
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.771 0.229
E63 Other nutritional deficiencies
0.000 0.771 0.229
E50 Vitamin A deficiency
0.000 0.771 0.229
E60 Dietary zinc deficiency
0.000 0.771 0.229
E59 Dietary selenium deficiency
0.000 0.771 0.229
E52 Niacin deficiency [pellagra]
0.000 0.771 0.229
E51 Thiamine deficiency
0.000 0.773 0.227
E56 Other vitamin deficiencies
0.000 0.784 0.216
E20-E35 Disorders of other endocrine glands
0.000 0.789 0.211
E55 Vitamin D deficiency
0.000 0.795 0.205
E58 Dietary calcium deficiency
0.000 0.802 0.198
E11.8 With unspecified complications
0.000 0.802 0.198
E24 Cushing's syndrome
0.000 0.812 0.188
K90.9 Intestinal malabsorption, unspecified
0.000 0.816 0.184
E83 Disorders of mineral metabolism
0.164 0.818 0.019
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.821 0.179
E65 Localised adiposity
0.000 0.828 0.171
E21.3 Hyperparathyroidism, unspecified
0.000 0.829 0.171
E61 Deficiency of other nutrient elements
0.000 0.830 0.169
I83 Varicose veins of lower extremities
0.169 0.831 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.000 0.831 0.169
E67.8 Other specified hyperalimentation
0.000 0.835 0.165
E67.3 Hypervitaminosis D
0.000 0.835 0.165
E67.2 Megavitamin-B6 syndrome
0.000 0.835 0.165
E67.1 Hypercarotenaemia
0.000 0.835 0.165
E67.0 Hypervitaminosis A
0.000 0.835 0.165
E11.5 With peripheral circulatory complications
0.000 0.835 0.165
E50.9 Vitamin A deficiency, unspecified
0.000 0.836 0.164
E50.8 Other manifestations of vitamin A deficiency
0.000 0.836 0.164
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.836 0.164
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.836 0.164
E50.5 Vitamin A deficiency with night blindness
0.000 0.836 0.164
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.836 0.164
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.836 0.164
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.836 0.164
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.836 0.164
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.836 0.164
E63.9 Nutritional deficiency, unspecified
0.000 0.836 0.164
E63.8 Other specified nutritional deficiencies
0.000 0.836 0.164
E63.1 Imbalance of constituents of food intake
0.000 0.836 0.164
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.836 0.164
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.836 0.164
E64.8 Sequelae of other nutritional deficiencies
0.000 0.836 0.164
E64.3 Sequelae of rickets
0.000 0.836 0.164
E64.2 Sequelae of vitamin C deficiency
0.000 0.836 0.164
E64.1 Sequelae of vitamin A deficiency
0.000 0.836 0.164
E64.0 Sequelae of protein-energy malnutrition
0.000 0.836 0.164
E53 Deficiency of other B group vitamins
0.000 0.837 0.163
E51.9 Thiamine deficiency, unspecified
0.000 0.837 0.163
E51.8 Other manifestations of thiamine deficiency
0.000 0.837 0.163
E51.1 Beriberi
0.000 0.837 0.163
E51.2 Wernicke's encephalopathy
0.000 0.839 0.161
E28 Ovarian dysfunction
0.000 0.841 0.159
E20 Hypoparathyroidism
0.000 0.843 0.157
E24.9 Cushing's syndrome, unspecified
0.000 0.843 0.157
E24.0 Pituitary-dependent Cushing's disease
0.000 0.844 0.156
E56.9 Vitamin deficiency, unspecified
0.000 0.845 0.155
E56.8 Deficiency of other vitamins
0.000 0.845 0.155
E56.0 Deficiency of vitamin E
0.000 0.845 0.155
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.849 0.151
E32 Diseases of thymus
0.000 0.849 0.151
E30 Disorders of puberty, not elsewhere classified
0.000 0.849 0.151
E25 Adrenogenital disorders
0.000 0.850 0.150
E31 Polyglandular dysfunction
0.000 0.852 0.148
E55.0 Rickets, active
0.000 0.852 0.147
E06.3 Autoimmune thyroiditis
0.001 0.853 0.147
E83.3 Disorders of phosphorus metabolism
0.138 0.857 0.005
E24.2 Drug-induced Cushing's syndrome
0.000 0.858 0.142
E56.1 Deficiency of vitamin K
0.000 0.858 0.142
E14.9 Without complications
0.000 0.861 0.139
E24.8 Other Cushing's syndrome
0.000 0.863 0.137
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.865 0.135
E24.3 Ectopic ACTH syndrome
0.000 0.865 0.135
E24.1 Nelson's syndrome
0.000 0.865 0.135
E83.8 Other disorders of mineral metabolism
0.117 0.869 0.014
E83.2 Disorders of zinc metabolism
0.117 0.869 0.014
E83.0 Disorders of copper metabolism
0.117 0.869 0.014
E83.9 Disorder of mineral metabolism, unspecified
0.117 0.870 0.013
M45 Ankylosing spondylitis
0.130 0.870 0.000
E29 Testicular dysfunction
0.000 0.870 0.129
E21.2 Other hyperparathyroidism
0.000 0.871 0.129
E21.4 Other specified disorders of parathyroid gland
0.000 0.871 0.129
E28.2 Polycystic ovarian syndrome
0.000 0.874 0.126
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.874 0.125
I83.0 Varicose veins of lower extremities with ulcer
0.125 0.875 0.000
E55.9 Vitamin D deficiency, unspecified
0.000 0.876 0.124
E61.9 Deficiency of nutrient element, unspecified
0.000 0.878 0.122
E61.8 Deficiency of other specified nutrient elements
0.000 0.878 0.122
E61.7 Deficiency of multiple nutrient elements
0.000 0.878 0.122
E61.6 Vanadium deficiency
0.000 0.878 0.122
E61.5 Molybdenum deficiency
0.000 0.878 0.122
E61.4 Chromium deficiency
0.000 0.878 0.122
E61.3 Manganese deficiency
0.000 0.878 0.122
E61.0 Copper deficiency
0.000 0.878 0.122
E53.9 Vitamin B deficiency, unspecified
0.000 0.880 0.120
E20.9 Hypoparathyroidism, unspecified
0.000 0.881 0.119
E03.9 Hypothyroidism, unspecified
0.000 0.882 0.118
E53.1 Pyridoxine deficiency
0.000 0.883 0.117
E53.0 Riboflavin deficiency
0.000 0.883 0.117
E34 Other endocrine disorders
0.000 0.883 0.117
E28.9 Ovarian dysfunction, unspecified
0.000 0.886 0.114
E28.8 Other ovarian dysfunction
0.000 0.886 0.114
E28.1 Androgen excess
0.000 0.886 0.114
E28.0 Oestrogen excess
0.000 0.886 0.114
E20.8 Other hypoparathyroidism
0.000 0.887 0.113
E20.1 Pseudohypoparathyroidism
0.000 0.887 0.113
E20.0 Idiopathic hypoparathyroidism
0.000 0.887 0.113
E30.9 Disorder of puberty, unspecified
0.000 0.891 0.109
E30.8 Other disorders of puberty
0.000 0.891 0.109
E30.1 Precocious puberty
0.000 0.891 0.109
E30.0 Delayed puberty
0.000 0.891 0.109
E32.9 Disease of thymus, unspecified
0.000 0.891 0.109
E32.8 Other diseases of thymus
0.000 0.891 0.109
E32.1 Abscess of thymus
0.000 0.891 0.109
E32.0 Persistent hyperplasia of thymus
0.000 0.891 0.109
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.891 0.109
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.891 0.109
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.891 0.109
E25.9 Adrenogenital disorder, unspecified
0.000 0.892 0.108
E25.8 Other adrenogenital disorders
0.000 0.892 0.108
E28.3 Primary ovarian failure
0.000 0.892 0.107
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.893 0.107
E61.2 Magnesium deficiency
0.000 0.893 0.107
E31.9 Polyglandular dysfunction, unspecified
0.000 0.893 0.106
E31.8 Other polyglandular dysfunction
0.000 0.893 0.106
E31.1 Polyglandular hyperfunction
0.000 0.893 0.106
E11.3 With ophthalmic complications
0.000 0.894 0.106
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.895 0.105
E31.0 Autoimmune polyglandular failure
0.000 0.896 0.104
E70-E90 Metabolic disorders
0.002 0.897 0.101
M45.X2 Ankylosing spondylitis (Cervical region)
0.103 0.897 0.000
C15-C26 Malignant neoplasms of digestive organs
0.000 0.898 0.102
M45.X6 Ankylosing spondylitis (Lumbar region)
0.100 0.900 0.000
C20 Malignant neoplasm of rectum
0.000 0.900 0.100
E21.0 Primary hyperparathyroidism
0.000 0.900 0.100
C15 Malignant neoplasm of oesophagus
0.000 0.901 0.099
E26 Hyperaldosteronism
0.000 0.901 0.098
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.903 0.097
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.095 0.905 0.000
E78.2 Mixed hyperlipidaemia
0.000 0.905 0.095
E29.9 Testicular dysfunction, unspecified
0.000 0.906 0.094
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.093 0.907 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.093 0.907 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.093 0.907 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.093 0.907 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.093 0.907 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.093 0.907 0.000
E29.8 Other testicular dysfunction
0.000 0.907 0.093
E29.0 Testicular hyperfunction
0.000 0.907 0.093
C25 Malignant neoplasm of pancreas
0.000 0.910 0.090
C15.4 Middle third of oesophagus
0.000 0.911 0.089
E61.1 Iron deficiency
0.000 0.913 0.087
E34.3 Short stature, not elsewhere classified
0.000 0.915 0.085
E78.1 Pure hyperglyceridaemia
0.000 0.915 0.085
E34.5 Androgen resistance syndrome
0.000 0.916 0.084
E34.4 Constitutional tall stature
0.000 0.916 0.084
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.916 0.084
E34.1 Other hypersecretion of intestinal hormones
0.000 0.916 0.084
C15.5 Lower third of oesophagus
0.000 0.917 0.083
E22 Hyperfunction of pituitary gland
0.000 0.917 0.083
E23 Hypofunction and other disorders of pituitary gland
0.000 0.917 0.082
E88 Other metabolic disorders
0.001 0.919 0.081
C15.9 Oesophagus, unspecified
0.000 0.919 0.081
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.919 0.079
E74 Other disorders of carbohydrate metabolism
0.001 0.921 0.078
E34.8 Other specified endocrine disorders
0.000 0.921 0.078
E78.6 Lipoprotein deficiency
0.000 0.922 0.078
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.077 0.923 0.000
E78.5 Hyperlipidaemia, unspecified
0.000 0.923 0.077
C15.0 Cervical part of oesophagus
0.000 0.923 0.077
E34.9 Endocrine disorder, unspecified
0.000 0.924 0.076
C25.2 Tail of pancreas
0.000 0.924 0.076
E84 Cystic fibrosis
0.001 0.925 0.073
C15.3 Upper third of oesophagus
0.000 0.925 0.074
C25.3 Pancreatic duct
0.000 0.926 0.074
E77 Disorders of glycoprotein metabolism
0.001 0.926 0.073
E76 Disorders of glycosaminoglycan metabolism
0.001 0.926 0.073
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.926 0.073
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.926 0.073
C17 Malignant neoplasm of small intestine
0.000 0.926 0.074
E85 Amyloidosis
0.001 0.927 0.072
E78.3 Hyperchylomicronaemia
0.000 0.927 0.073
E73 Lactose intolerance
0.001 0.927 0.072
C25.1 Body of pancreas
0.000 0.927 0.073
E11.4 With neurological complications
0.000 0.928 0.072
C15.1 Thoracic part of oesophagus
0.000 0.928 0.072
C25.4 Endocrine pancreas
0.000 0.928 0.072
E23.7 Disorder of pituitary gland, unspecified
0.000 0.929 0.071
C15.8 Overlapping lesion of oesophagus
0.000 0.929 0.071
C15.2 Abdominal part of oesophagus
0.000 0.929 0.071
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.000 0.929 0.071
E26.8 Other hyperaldosteronism
0.000 0.929 0.071
E26.1 Secondary hyperaldosteronism
0.000 0.929 0.071
C17.0 Duodenum
0.000 0.930 0.070
E70 Disorders of aromatic amino-acid metabolism
0.001 0.930 0.069
E88.9 Metabolic disorder, unspecified
0.000 0.930 0.070
C25.8 Overlapping lesion of pancreas
0.000 0.930 0.070
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.930 0.069
E34.0 Carcinoid syndrome
0.000 0.931 0.069
E79 Disorders of purine and pyrimidine metabolism
0.001 0.931 0.068
E29.1 Testicular hypofunction
0.000 0.931 0.069
C21 Malignant neoplasm of anus and anal canal
0.000 0.932 0.068
E83.4 Disorders of magnesium metabolism
0.060 0.932 0.008
E72 Other disorders of amino-acid metabolism
0.001 0.933 0.066
C25.9 Pancreas, unspecified
0.000 0.934 0.066
E88.2 Lipomatosis, not elsewhere classified
0.000 0.936 0.064
E75.5 Other lipid storage disorders
0.001 0.936 0.063
R31 Unspecified haematuria
0.063 0.937 0.000
C24.0 Extrahepatic bile duct
0.000 0.937 0.062
E26.9 Hyperaldosteronism, unspecified
0.001 0.938 0.062
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.938 0.062
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.938 0.062
E78.4 Other hyperlipidaemia
0.000 0.938 0.062
E85.4 Organ-limited amyloidosis
0.001 0.940 0.060
E22.8 Other hyperfunction of pituitary gland
0.000 0.940 0.060
I83.1 Varicose veins of lower extremities with inflammation
0.060 0.940 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.941 0.059
E23.1 Drug-induced hypopituitarism
0.000 0.941 0.059
E75.2 Other sphingolipidosis
0.001 0.941 0.058
C25.7 Other parts of pancreas
0.000 0.941 0.058
E75.6 Lipid storage disorder, unspecified
0.001 0.942 0.057
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.942 0.057
E75.3 Sphingolipidosis, unspecified
0.001 0.942 0.057
E75.1 Other gangliosidosis
0.001 0.942 0.057
E75.0 GM2 gangliosidosis
0.001 0.942 0.057
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.943 0.056
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.943 0.056
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.943 0.056
E74.2 Disorders of galactose metabolism
0.001 0.943 0.056
E74.1 Disorders of fructose metabolism
0.001 0.943 0.056
E22.1 Hyperprolactinaemia
0.000 0.944 0.056
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.944 0.056
E85.3 Secondary systemic amyloidosis
0.001 0.945 0.054
E88.8 Other specified metabolic disorders
0.001 0.945 0.055
E74.0 Glycogen storage disease
0.001 0.945 0.054
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.945 0.054
C21.8 Overlapping lesion of rectum, anus and anal canal
0.000 0.946 0.054
E84.8 Cystic fibrosis with other manifestations
0.001 0.946 0.053
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.946 0.053
E71.3 Disorders of fatty-acid metabolism
0.001 0.947 0.052
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.947 0.052
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.947 0.052
E71.0 Maple-syrup-urine disease
0.001 0.947 0.052
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.947 0.052
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.947 0.052
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.947 0.052
E76.2 Other mucopolysaccharidoses
0.001 0.947 0.052
E76.1 Mucopolysaccharidosis, type II
0.001 0.947 0.052
E76.0 Mucopolysaccharidosis, type I
0.001 0.947 0.052
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.947 0.052
E77.8 Other disorders of glycoprotein metabolism
0.001 0.947 0.052
E77.1 Defects in glycoprotein degradation
0.001 0.947 0.052
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.947 0.052
C17.8 Overlapping lesion of small intestine
0.000 0.947 0.053
C17.3 Meckel's diverticulum
0.000 0.947 0.053
E85.8 Other amyloidosis
0.001 0.947 0.052
E84.9 Cystic fibrosis, unspecified
0.001 0.947 0.052
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.947 0.052
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.947 0.052
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.947 0.052
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.947 0.053
E73.8 Other lactose intolerance
0.001 0.947 0.052
E73.1 Secondary lactase deficiency
0.001 0.947 0.052
E73.0 Congenital lactase deficiency
0.001 0.947 0.052
E73.9 Lactose intolerance, unspecified
0.001 0.949 0.051
C24.8 Overlapping lesion of biliary tract
0.000 0.949 0.051
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.949 0.050
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.949 0.050
E70.2 Disorders of tyrosine metabolism
0.001 0.949 0.050
E70.1 Other hyperphenylalaninaemias
0.001 0.949 0.050
E70.0 Classical phenylketonuria
0.001 0.949 0.050
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.950 0.049
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.950 0.049
E79.1 Lesch-Nyhan syndrome
0.001 0.950 0.049
C21.2 Cloacogenic zone
0.000 0.951 0.049
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.951 0.047
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.951 0.047
E72.5 Disorders of glycine metabolism
0.001 0.951 0.047
E72.4 Disorders of ornithine metabolism
0.001 0.951 0.047
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.951 0.047
E72.2 Disorders of urea cycle metabolism
0.001 0.951 0.047
E88.3 Tumour lysis syndrome
0.001 0.952 0.048
C24.9 Biliary tract, unspecified
0.000 0.952 0.048
E04 Other non-toxic goitre
0.002 0.952 0.046
C17.1 Jejunum
0.000 0.953 0.047
E72.0 Disorders of amino-acid transport
0.001 0.953 0.046
C23 Malignant neoplasm of gallbladder
0.000 0.953 0.047
E70.3 Albinism
0.001 0.953 0.046
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.954 0.046
C26 Malignant neoplasm of other and ill-defined digestive organs
0.000 0.955 0.045
E53.8 Deficiency of other specified B group vitamins
0.000 0.955 0.045
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.955 0.044
E78.8 Other disorders of lipoprotein metabolism
0.000 0.956 0.044
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.956 0.042
C21.1 Anal canal
0.000 0.957 0.043
E23.6 Other disorders of pituitary gland
0.000 0.958 0.042
C21.0 Anus, unspecified
0.000 0.958 0.042
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.000 0.959 0.041
E23.2 Diabetes insipidus
0.000 0.959 0.041
E22.0 Acromegaly and pituitary gigantism
0.000 0.960 0.040
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.960 0.038
E78.0 Pure hypercholesterolaemia
0.000 0.962 0.038
E26.0 Primary hyperaldosteronism
0.001 0.962 0.037
E85.9 Amyloidosis, unspecified
0.001 0.965 0.034
C17.9 Small intestine, unspecified
0.000 0.965 0.035
C17.2 Ileum
0.000 0.965 0.034
E04.8 Other specified non-toxic goitre
0.002 0.965 0.033
C26.8 Overlapping lesion of digestive system
0.000 0.967 0.032
C26.1 Spleen
0.000 0.967 0.032
E27 Other disorders of adrenal gland
0.000 0.969 0.030
E80.2 Other porphyria
0.001 0.970 0.029
C25.0 Head of pancreas
0.000 0.970 0.030
C22.7 Other specified carcinomas of liver
0.000 0.970 0.030
C22.4 Other sarcomas of liver
0.000 0.970 0.030
C22.3 Angiosarcoma of liver
0.000 0.970 0.030
C22.2 Hepatoblastoma
0.000 0.970 0.030
M45-M49 Spondylopathies
0.030 0.970 0.000
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.971 0.028
E80.5 Crigler-Najjar syndrome
0.001 0.971 0.028
E80.3 Defects of catalase and peroxydase
0.001 0.971 0.028
E80.0 Hereditary erythropoietic porphyria
0.001 0.971 0.028
C22.9 Liver, unspecified
0.000 0.972 0.028
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.028 0.972 0.000
C24.1 Ampulla of Vater
0.001 0.972 0.027
E66 Obesity
0.000 0.973 0.027
C22.1 Intrahepatic bile duct carcinoma
0.000 0.973 0.027
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.026 0.974 0.000
E04.0 Non-toxic diffuse goitre
0.002 0.974 0.024
E11.9 Without complications
0.000 0.975 0.025
I86 Varicose veins of other sites
0.025 0.975 0.000
K90-K93 Other diseases of the digestive system
0.000 0.975 0.025
E80.6 Other disorders of bilirubin metabolism
0.001 0.976 0.023
I89.0 Lymphoedema, not elsewhere classified
0.024 0.976 0.000
I89.9 Non-infective disorder of lymphatic vessels and lymph nodes, unspecified
0.024 0.976 0.000
E80.1 Porphyria cutanea tarda
0.001 0.976 0.023
I86.8 Varicose veins of other specified sites
0.024 0.976 0.000
C26.9 Ill-defined sites within the digestive system
0.001 0.977 0.023
E23.0 Hypopituitarism
0.000 0.977 0.023
M49 Spondylopathies in diseases classified elsewhere
0.023 0.977 0.000
I81 Portal vein thrombosis
0.022 0.978 0.000
E27.5 Adrenomedullary hyperfunction
0.000 0.978 0.022
E27.0 Other adrenocortical overactivity
0.000 0.978 0.022
C26.0 Intestinal tract, part unspecified
0.000 0.978 0.022
C16 Malignant neoplasm of stomach
0.000 0.978 0.022
M46 Other inflammatory spondylopathies
0.021 0.979 0.000
I89.1 Lymphangitis
0.021 0.979 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.980 0.020
E66.1 Drug-induced obesity
0.000 0.980 0.020
I86.4 Gastric varices
0.020 0.980 0.000
M46.9 Inflammatory spondylopathy, unspecified
0.020 0.980 0.000
I73.9 Peripheral vascular disease, unspecified
0.000 0.981 0.019
E27.9 Disorder of adrenal gland, unspecified
0.000 0.981 0.019
E83.5 Disorders of calcium metabolism
0.007 0.981 0.013
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)
0.019 0.981 0.000
E27.2 Addisonian crisis
0.000 0.981 0.019
I86.3 Vulval varices
0.019 0.981 0.000
I86.2 Pelvic varices
0.019 0.981 0.000
C18.1 Appendix
0.000 0.981 0.019
I73 Other peripheral vascular diseases
0.000 0.982 0.018
I85 Oesophageal varices
0.018 0.982 0.000
I82 Other venous embolism and thrombosis
0.018 0.982 0.000
C18 Malignant neoplasm of colon
0.000 0.982 0.018
I86.0 Sublingual varices
0.018 0.982 0.000
M49.5 Collapsed vertebra in diseases classified elsewhere
0.018 0.982 0.000
I77 Other disorders of arteries and arterioles
0.000 0.982 0.018
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.982 0.018
I77.6 Arteritis, unspecified
0.000 0.982 0.018
M47.12 Other spondylosis with myelopathy (Cervical region)
0.018 0.982 0.000
I88 Nonspecific lymphadenitis
0.017 0.983 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.983 0.017
I87 Other disorders of veins
0.017 0.983 0.000
M47.1 Other spondylosis with myelopathy
0.017 0.983 0.000
C18.9 Colon, unspecified
0.000 0.983 0.017

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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