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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3828903
log Bayes Factor = 65.162
Chromosome 6   position 31,464,739  (GRCh37) Explore rs3828903 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
M45 Ankylosing spondylitis
0.999 0.001 0.000
R31 Unspecified haematuria
0.998 0.002 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.997 0.003 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.003 0.997
E10-E14 Diabetes mellitus
0.000 0.004 0.996
E05.9 Thyrotoxicosis, unspecified
0.000 0.005 0.995
E00-E07 Disorders of thyroid gland
0.000 0.007 0.993
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.008 0.992
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.016 0.984
E10.2 With renal complications
0.000 0.023 0.977
E10.9 Without complications
0.000 0.027 0.973
E10.3 With ophthalmic complications
0.000 0.037 0.963
G35 Multiple sclerosis
0.000 0.043 0.957
M45.X2 Ankylosing spondylitis (Cervical region)
0.951 0.049 0.000
E10.1 With ketoacidosis
0.000 0.063 0.937
K90 Intestinal malabsorption
0.000 0.072 0.928
E10.4 With neurological complications
0.000 0.078 0.922
K90.9 Intestinal malabsorption, unspecified
0.000 0.091 0.909
E20-E35 Disorders of other endocrine glands
0.000 0.095 0.905
E27 Other disorders of adrenal gland
0.000 0.101 0.899
E50-E64 Other nutritional deficiencies
0.000 0.108 0.892
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.119 0.881
E27.1 Primary adrenocortical insufficiency
0.000 0.121 0.879
E06 Thyroiditis
0.000 0.132 0.868
G37 Other demyelinating diseases of central nervous system
0.000 0.133 0.867
E11 Non-insulin-dependent diabetes mellitus
0.000 0.133 0.867
E10.8 With unspecified complications
0.000 0.137 0.863
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.140 0.860
E05.8 Other thyrotoxicosis
0.000 0.144 0.856
M45.X6 Ankylosing spondylitis (Lumbar region)
0.841 0.159 0.000
E11.5 With peripheral circulatory complications
0.000 0.160 0.840
E10.5 With peripheral circulatory complications
0.000 0.177 0.823
E10.6 With other specified complications
0.000 0.189 0.811
E27.8 Other specified disorders of adrenal gland
0.000 0.203 0.797
E53 Deficiency of other B group vitamins
0.000 0.206 0.794
I25 Chronic ischaemic heart disease
0.794 0.206 0.000
E06.9 Thyroiditis, unspecified
0.000 0.207 0.793
I20 Angina pectoris
0.792 0.208 0.000
I20-I25 Ischaemic heart diseases
0.791 0.209 0.000
I20.0 Unstable angina
0.787 0.213 0.000
E61 Deficiency of other nutrient elements
0.000 0.213 0.787
I25.1 Atherosclerotic heart disease
0.786 0.214 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.229 0.770
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.247 0.753
I24 Other acute ischaemic heart diseases
0.753 0.247 0.000
I20.9 Angina pectoris, unspecified
0.743 0.257 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.261 0.739
E34 Other endocrine disorders
0.000 0.267 0.733
E20 Hypoparathyroidism
0.000 0.269 0.731
E27.2 Addisonian crisis
0.000 0.275 0.725
I25.9 Chronic ischaemic heart disease, unspecified
0.725 0.275 0.000
E14 Unspecified diabetes mellitus
0.000 0.276 0.724
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.719 0.281 0.000
E10.7 With multiple complications
0.000 0.283 0.717
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.283 0.717
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.283 0.717
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.716 0.284 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.716 0.284 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.716 0.284 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.716 0.284 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.716 0.284 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.716 0.284 0.000
E05.5 Thyroid crisis or storm
0.000 0.285 0.715
E05.4 Thyrotoxicosis factitia
0.000 0.285 0.715
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.285 0.715
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.285 0.715
E12 Malnutrition-related diabetes mellitus
0.000 0.286 0.714
I25.5 Ischaemic cardiomyopathy
0.713 0.287 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.288 0.712
E00 Congenital iodine-deficiency syndrome
0.000 0.288 0.712
E11.4 With neurological complications
0.000 0.296 0.704
E53.8 Deficiency of other specified B group vitamins
0.000 0.302 0.698
I20.1 Angina pectoris with documented spasm
0.696 0.304 0.000
E07 Other disorders of thyroid
0.000 0.312 0.688
E11.3 With ophthalmic complications
0.000 0.314 0.686
E40-E46 Malnutrition
0.000 0.316 0.684
E61.1 Iron deficiency
0.000 0.316 0.684
E11.6 With other specified complications
0.000 0.321 0.679
K90.3 Pancreatic steatorrhoea
0.000 0.335 0.665
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.335 0.665
K90.1 Tropical sprue
0.000 0.335 0.665
K90.8 Other intestinal malabsorption
0.000 0.346 0.654
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.351 0.649
E32 Diseases of thymus
0.000 0.351 0.649
E31 Polyglandular dysfunction
0.000 0.351 0.649
E30 Disorders of puberty, not elsewhere classified
0.000 0.351 0.649
E27.5 Adrenomedullary hyperfunction
0.000 0.355 0.645
E27.0 Other adrenocortical overactivity
0.000 0.355 0.645
E51 Thiamine deficiency
0.000 0.357 0.643
E25 Adrenogenital disorders
0.000 0.357 0.643
I24.8 Other forms of acute ischaemic heart disease
0.640 0.360 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.361 0.639
E63 Other nutritional deficiencies
0.000 0.361 0.639
E50 Vitamin A deficiency
0.000 0.361 0.639
E60 Dietary zinc deficiency
0.000 0.361 0.639
E59 Dietary selenium deficiency
0.000 0.361 0.639
E54 Ascorbic acid deficiency
0.000 0.361 0.639
E52 Niacin deficiency [pellagra]
0.000 0.361 0.639
I25.2 Old myocardial infarction
0.639 0.361 0.000
E10.0 With coma
0.000 0.363 0.637
E53.9 Vitamin B deficiency, unspecified
0.000 0.367 0.633
I23 Certain current complications following acute myocardial infarction
0.632 0.368 0.000
E11.1 With ketoacidosis
0.000 0.376 0.624
E61.2 Magnesium deficiency
0.000 0.376 0.624
E06.4 Drug-induced thyroiditis
0.000 0.378 0.622
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.378 0.622
E06.1 Subacute thyroiditis
0.000 0.378 0.622
E06.0 Acute thyroiditis
0.000 0.378 0.622
G37.5 Concentric sclerosis [Balo]
0.000 0.378 0.622
G37.4 Subacute necrotising myelitis
0.000 0.378 0.622
G37.2 Central pontine myelinolysis
0.000 0.378 0.622
G37.1 Central demyelination of corpus callosum
0.000 0.378 0.622
G37.0 Diffuse sclerosis
0.000 0.378 0.622
E11.7 With multiple complications
0.000 0.378 0.622
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.383 0.617
G36 Other acute disseminated demyelination
0.000 0.384 0.616
E06.3 Autoimmune thyroiditis
0.000 0.385 0.615
E56 Other vitamin deficiencies
0.000 0.388 0.612
E20.9 Hypoparathyroidism, unspecified
0.000 0.394 0.606
E11.8 With unspecified complications
0.000 0.394 0.606
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.396 0.604
E14.3 With ophthalmic complications
0.000 0.400 0.600
E34.9 Endocrine disorder, unspecified
0.000 0.401 0.599
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.403 0.597
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.412 0.588
E14.5 With peripheral circulatory complications
0.000 0.414 0.586
E06.5 Other chronic thyroiditis
0.000 0.417 0.583
I25.6 Silent myocardial ischaemia
0.579 0.420 0.000
E14.1 With ketoacidosis
0.000 0.421 0.579
E58 Dietary calcium deficiency
0.000 0.423 0.577
E53.1 Pyridoxine deficiency
0.000 0.430 0.570
E53.0 Riboflavin deficiency
0.000 0.430 0.570
E27.9 Disorder of adrenal gland, unspecified
0.000 0.433 0.567
E61.9 Deficiency of nutrient element, unspecified
0.000 0.436 0.564
E61.8 Deficiency of other specified nutrient elements
0.000 0.436 0.564
E61.7 Deficiency of multiple nutrient elements
0.000 0.436 0.564
E61.6 Vanadium deficiency
0.000 0.436 0.564
E61.5 Molybdenum deficiency
0.000 0.436 0.564
E61.4 Chromium deficiency
0.000 0.436 0.564
E61.3 Manganese deficiency
0.000 0.436 0.564
E61.0 Copper deficiency
0.000 0.436 0.564
I25.4 Coronary artery aneurysm
0.564 0.436 0.000
E55 Vitamin D deficiency
0.000 0.439 0.561
E21.0 Primary hyperparathyroidism
0.000 0.440 0.560
I25.8 Other forms of chronic ischaemic heart disease
0.554 0.446 0.000
E29 Testicular dysfunction
0.000 0.448 0.552
E13 Other specified diabetes mellitus
0.000 0.453 0.547
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.454 0.545
E34.8 Other specified endocrine disorders
0.000 0.461 0.539
E14.6 With other specified complications
0.000 0.462 0.538
E14.8 With unspecified complications
0.000 0.466 0.534
E24 Cushing's syndrome
0.000 0.467 0.533
I24.9 Acute ischaemic heart disease, unspecified
0.533 0.467 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.469 0.531
E34.0 Carcinoid syndrome
0.000 0.470 0.530
E34.5 Androgen resistance syndrome
0.000 0.474 0.526
E34.4 Constitutional tall stature
0.000 0.474 0.526
E34.3 Short stature, not elsewhere classified
0.000 0.474 0.526
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.474 0.526
E34.1 Other hypersecretion of intestinal hormones
0.000 0.474 0.526
E26 Hyperaldosteronism
0.000 0.475 0.525
E20.8 Other hypoparathyroidism
0.000 0.476 0.524
E20.1 Pseudohypoparathyroidism
0.000 0.476 0.524
E20.0 Idiopathic hypoparathyroidism
0.000 0.476 0.524
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.477 0.523
E14.7 With multiple complications
0.000 0.481 0.519
E14.2 Withrenal complications
0.000 0.481 0.519
E14.0 With coma
0.000 0.481 0.519
I23.8 Other current complications following acute myocardial infarction
0.518 0.481 0.000
E21.4 Other specified disorders of parathyroid gland
0.000 0.486 0.514
E12.9 Without complications
0.000 0.488 0.512
E12.8 With unspecified complications
0.000 0.488 0.512
E12.7 With multiple complications
0.000 0.488 0.512
E12.6 With other specified complications
0.000 0.488 0.512
E12.5 With peripheral circulatory complications
0.000 0.488 0.512
E12.4 With neurological complications
0.000 0.488 0.512
E12.3 With ophthalmic complications
0.000 0.488 0.512
E12.2 With renal complications
0.000 0.488 0.512
E12.1 With ketoacidosis
0.000 0.488 0.512
E12.0 With coma
0.000 0.488 0.512
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.489 0.510
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.489 0.510
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.489 0.510
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.489 0.510
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.489 0.510
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.489 0.510
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.489 0.510
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.489 0.510
I25.3 Aneurysm of heart
0.498 0.502 0.000
E07.1 Dyshormogenetic goitre
0.000 0.506 0.493
E07.0 Hypersecretion of calcitonin
0.000 0.506 0.493
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.509 0.491
E45 Retarded development following protein-energy malnutrition
0.000 0.509 0.491
E43 Unspecified severe protein-energy malnutrition
0.000 0.509 0.491
E42 Marasmic kwashiorkor
0.000 0.509 0.491
E41 Nutritional marasmus
0.000 0.509 0.491
E40 Kwashiorkor
0.000 0.509 0.491
E21.2 Other hyperparathyroidism
0.000 0.509 0.491
E11.2 With renal complications
0.000 0.510 0.490
E14.4 With neurological complications
0.000 0.511 0.489
E51.2 Wernicke's encephalopathy
0.000 0.534 0.465
E30.9 Disorder of puberty, unspecified
0.000 0.535 0.465
E30.8 Other disorders of puberty
0.000 0.535 0.465
E30.1 Precocious puberty
0.000 0.535 0.465
E30.0 Delayed puberty
0.000 0.535 0.465
E31.9 Polyglandular dysfunction, unspecified
0.000 0.535 0.465
E31.8 Other polyglandular dysfunction
0.000 0.535 0.465
E31.1 Polyglandular hyperfunction
0.000 0.535 0.465
E31.0 Autoimmune polyglandular failure
0.000 0.535 0.465
E32.9 Disease of thymus, unspecified
0.000 0.535 0.465
E32.8 Other diseases of thymus
0.000 0.535 0.465
E32.1 Abscess of thymus
0.000 0.535 0.465
E32.0 Persistent hyperplasia of thymus
0.000 0.535 0.465
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.535 0.465
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.535 0.465
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.535 0.465
E46 Unspecified protein-energy malnutrition
0.000 0.537 0.463
E51.9 Thiamine deficiency, unspecified
0.000 0.539 0.461
E51.8 Other manifestations of thiamine deficiency
0.000 0.539 0.461
E51.1 Beriberi
0.000 0.539 0.461
E25.9 Adrenogenital disorder, unspecified
0.000 0.539 0.461
E25.8 Other adrenogenital disorders
0.000 0.539 0.461
I25.0 Atherosclerotic cardiovascular disease, so described
0.458 0.541 0.000
E50.9 Vitamin A deficiency, unspecified
0.000 0.541 0.458
E50.8 Other manifestations of vitamin A deficiency
0.000 0.541 0.458
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.541 0.458
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.541 0.458
E50.5 Vitamin A deficiency with night blindness
0.000 0.541 0.458
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.541 0.458
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.541 0.458
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.541 0.458
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.541 0.458
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.541 0.458
E63.9 Nutritional deficiency, unspecified
0.000 0.541 0.458
E63.8 Other specified nutritional deficiencies
0.000 0.541 0.458
E63.1 Imbalance of constituents of food intake
0.000 0.541 0.458
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.541 0.458
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.541 0.458
E64.8 Sequelae of other nutritional deficiencies
0.000 0.541 0.458
E64.3 Sequelae of rickets
0.000 0.541 0.458
E64.2 Sequelae of vitamin C deficiency
0.000 0.541 0.458
E64.1 Sequelae of vitamin A deficiency
0.000 0.541 0.458
E64.0 Sequelae of protein-energy malnutrition
0.000 0.541 0.458
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.544 0.455
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.453 0.547 0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.453 0.547 0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.453 0.547 0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.453 0.547 0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.453 0.547 0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.453 0.547 0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.453 0.547 0.000
I24.1 Dressler's syndrome
0.442 0.557 0.000
G36.9 Acute disseminated demyelination, unspecified
0.000 0.558 0.442
G36.8 Other specified acute disseminated demyelination
0.000 0.558 0.442
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.558 0.442
E56.9 Vitamin deficiency, unspecified
0.000 0.561 0.439
E56.8 Deficiency of other vitamins
0.000 0.561 0.439
E56.0 Deficiency of vitamin E
0.000 0.561 0.439
G36.0 Neuromyelitis optica [Devic]
0.000 0.574 0.426
E21.3 Hyperparathyroidism, unspecified
0.000 0.580 0.420
E07.8 Other specified disorders of thyroid
0.000 0.582 0.418
E28 Ovarian dysfunction
0.000 0.588 0.412
E56.1 Deficiency of vitamin K
0.000 0.588 0.412
I22 Subsequent myocardial infarction
0.408 0.592 0.000
E55.0 Rickets, active
0.000 0.598 0.402
E11.0 With coma
0.000 0.602 0.398
R30.0 Dysuria
0.397 0.603 0.000
E29.9 Testicular dysfunction, unspecified
0.000 0.604 0.396
E29.8 Other testicular dysfunction
0.000 0.604 0.396
E29.0 Testicular hyperfunction
0.000 0.604 0.396
R30-R39 Symptoms and signs involving the urinary system
0.393 0.607 0.000
E13.8 With unspecified complications
0.000 0.608 0.392
E13.7 With multiple complications
0.000 0.608 0.392
E13.6 With other specified complications
0.000 0.608 0.392
E13.5 With peripheral circulatory complications
0.000 0.608 0.392
E13.4 With neurological complications
0.000 0.608 0.392
E13.2 With renal complications
0.000 0.608 0.392
E13.1 With ketoacidosis
0.000 0.608 0.392
E13.0 With coma
0.000 0.608 0.392
E13.3 With ophthalmic complications
0.000 0.609 0.391
E15 Nondiabetic hypoglycaemic coma
0.000 0.609 0.391
R30 Pain associated with micturition
0.391 0.609 0.000
E24.8 Other Cushing's syndrome
0.000 0.618 0.382
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.618 0.382
E24.3 Ectopic ACTH syndrome
0.000 0.618 0.382
E24.1 Nelson's syndrome
0.000 0.618 0.382
E26.8 Other hyperaldosteronism
0.000 0.623 0.376
E26.1 Secondary hyperaldosteronism
0.000 0.623 0.376
E22 Hyperfunction of pituitary gland
0.000 0.625 0.375
I22.1 Subsequent myocardial infarction of inferior wall
0.371 0.629 0.000
E24.0 Pituitary-dependent Cushing's disease
0.000 0.631 0.369
I21 Acute myocardial infarction
0.367 0.633 0.000
R34 Anuria and oliguria
0.362 0.638 0.000
E26.9 Hyperaldosteronism, unspecified
0.000 0.639 0.361
I21.2 Acute transmural myocardial infarction of other sites
0.357 0.643 0.000
E24.2 Drug-induced Cushing's syndrome
0.000 0.645 0.355
E44.1 Mild protein-energy malnutrition
0.000 0.648 0.352
E44.0 Moderate protein-energy malnutrition
0.000 0.648 0.352
E65-E68 Obesity and other hyperalimentation
0.000 0.670 0.330
E24.9 Cushing's syndrome, unspecified
0.000 0.675 0.325
E55.9 Vitamin D deficiency, unspecified
0.000 0.676 0.324
E29.1 Testicular hypofunction
0.000 0.701 0.299
E23 Hypofunction and other disorders of pituitary gland
0.000 0.704 0.296
E28.9 Ovarian dysfunction, unspecified
0.000 0.704 0.295
E28.8 Other ovarian dysfunction
0.000 0.704 0.295
E28.1 Androgen excess
0.000 0.704 0.295
E28.0 Oestrogen excess
0.000 0.704 0.295
E03 Other hypothyroidism
0.001 0.707 0.292
R30.1 Vesical tenesmus
0.284 0.716 0.000
E26.0 Primary hyperaldosteronism
0.000 0.721 0.278
I21.9 Acute myocardial infarction, unspecified
0.275 0.725 0.000
E28.3 Primary ovarian failure
0.000 0.728 0.272
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.731 0.269
E22.8 Other hyperfunction of pituitary gland
0.000 0.731 0.269
I21.X Presumed acute myicardial infaction (unconfirmed)
0.263 0.737 0.000
R36 Urethral discharge
0.258 0.742 0.000
E67 Other hyperalimentation
0.000 0.763 0.237
E68 Sequelae of hyperalimentation
0.000 0.763 0.237
E22.1 Hyperprolactinaemia
0.000 0.765 0.235
I22.8 Subsequent myocardial infarction of other sites
0.229 0.771 0.000
E13.9 Without complications
0.000 0.774 0.226
E16 Other disorders of pancreatic internal secretion
0.000 0.775 0.225
E23.7 Disorder of pituitary gland, unspecified
0.000 0.775 0.224
M25.55 Pain in joint (Pelvic region and thigh)
0.000 0.780 0.220
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.788 0.212
E23.1 Drug-induced hypopituitarism
0.000 0.788 0.212
E03.5 Myxoedema coma
0.001 0.790 0.209
E03.4 Atrophy of thyroid (acquired)
0.001 0.790 0.209
E03.3 Postinfectious hypothyroidism
0.001 0.790 0.209
E03.0 Congenital hypothyroidism with diffuse goitre
0.001 0.790 0.209
E22.0 Acromegaly and pituitary gigantism
0.000 0.791 0.209
M25.54 Pain in joint (Hand)
0.000 0.793 0.207
M25.5 Pain in joint
0.000 0.793 0.207
E03.1 Congenital hypothyroidism without goitre
0.001 0.794 0.205
I20.8 Other forms of angina pectoris
0.200 0.800 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.199 0.801 0.000
E03.8 Other specified hypothyroidism
0.001 0.807 0.192
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.810 0.190
M25.53 Pain in joint (Forearm)
0.000 0.812 0.188
E23.2 Diabetes insipidus
0.000 0.818 0.182
I22.0 Subsequent myocardial infarction of anterior wall
0.179 0.820 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.001 0.821 0.178
R30.9 Painful micturition, unspecified
0.178 0.821 0.000
M25 Other joint disorders, not elsewhere classified
0.000 0.824 0.176
M25.58 Pain in joint (Other)
0.000 0.826 0.174
M25.6 Stiffness of joint, not elsewhere classified
0.000 0.827 0.173
E67.8 Other specified hyperalimentation
0.000 0.830 0.170
E67.3 Hypervitaminosis D
0.000 0.830 0.170
E67.2 Megavitamin-B6 syndrome
0.000 0.830 0.170
E67.1 Hypercarotenaemia
0.000 0.830 0.170
E67.0 Hypervitaminosis A
0.000 0.830 0.170
M25.7 Osteophyte
0.000 0.832 0.168
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)
0.000 0.834 0.166
E04 Other non-toxic goitre
0.000 0.837 0.163
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.838 0.161
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.838 0.161
E16.4 Abnormal secretion of gastrin
0.000 0.838 0.161
E16.3 Increased secretion of glucagon
0.000 0.838 0.161
E65 Localised adiposity
0.000 0.845 0.155
M25.71 Osteophyte (Shoulder region)
0.000 0.845 0.154
M25.64 Stiffness of joint, not elsewhere classified (Hand)
0.000 0.849 0.151
M25.9 Joint disorder, unspecified
0.000 0.852 0.148
E11.9 Without complications
0.000 0.855 0.145
M25.72 Osteophyte (Upper arm)
0.000 0.857 0.143
M25.68 Stiffness of joint, not elsewhere classified (Other)
0.000 0.858 0.142
M25.77 Osteophyte (Ankle and foot)
0.000 0.859 0.141
E16.1 Other hypoglycaemia
0.000 0.861 0.139
M25.76 Osteophyte (Lower leg)
0.000 0.863 0.137
M25.52 Pain in joint (Upper arm)
0.000 0.863 0.137
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.864 0.136
M25.74 Osteophyte (Hand)
0.000 0.866 0.134
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)
0.000 0.867 0.133
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)
0.000 0.868 0.131
M25.96 Joint disorder, unspecified (Lower leg)
0.000 0.869 0.131
M25.0 Haemarthrosis
0.000 0.870 0.130
I22.9 Subsequent myocardial infarction of unspecified site
0.130 0.870 0.000
M25.73 Osteophyte (Forearm)
0.000 0.870 0.129
M25.57 Pain in joint (Ankle and foot)
0.000 0.871 0.129
M25.63 Stiffness of joint, not elsewhere classified (Forearm)
0.000 0.873 0.127
E23.6 Other disorders of pituitary gland
0.001 0.873 0.126
M25.50 Pain in joint (Multiple sites)
0.000 0.874 0.126
M25.2 Flail joint
0.000 0.874 0.126
M25.1 Fistula of joint
0.000 0.874 0.126
R39 Other symptoms and signs involving the urinary system
0.125 0.875 0.000
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)
0.000 0.876 0.124
E04.0 Non-toxic diffuse goitre
0.000 0.876 0.124
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)
0.000 0.877 0.123
M25.79 Osteophyte (Site unspecified)
0.000 0.878 0.122
M25.70 Osteophyte (Multiple sites)
0.000 0.879 0.121
I21.1 Acute transmural myocardial infarction of inferior wall
0.119 0.881 0.000
M25.91 Joint disorder, unspecified (Shoulder region)
0.000 0.881 0.119
E28.2 Polycystic ovarian syndrome
0.001 0.881 0.118
E04.8 Other specified non-toxic goitre
0.000 0.883 0.117
H20.9 Iridocyclitis, unspecified
0.116 0.884 0.000
M25.59 Pain in joint (Site unspecified)
0.000 0.884 0.116
M25.94 Joint disorder, unspecified (Hand)
0.000 0.887 0.113
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)
0.000 0.889 0.111
E23.0 Hypopituitarism
0.000 0.889 0.111
S02.40 Fracture of malar and maxillary bones (closed)
0.000 0.891 0.109
M25.98 Joint disorder, unspecified (Other)
0.000 0.893 0.106
M25.92 Joint disorder, unspecified (Upper arm)
0.000 0.893 0.106
M25.90 Joint disorder, unspecified (Multiple sites)
0.000 0.893 0.106
M25.78 Osteophyte (Other)
0.000 0.894 0.106
E16.2 Hypoglycaemia, unspecified
0.000 0.896 0.104
M25.99 Joint disorder, unspecified (Site unspecified)
0.000 0.897 0.102
M25.93 Joint disorder, unspecified (Forearm)
0.000 0.898 0.102
M25.95 Joint disorder, unspecified (Pelvic region and thigh)
0.000 0.899 0.101
M25.06 Haemarthrosis (Lower leg)
0.000 0.902 0.098
M25.09 Haemarthrosis (Site unspecified)
0.000 0.906 0.094
M25.08 Haemarthrosis (Other)
0.000 0.906 0.094
M25.07 Haemarthrosis (Ankle and foot)
0.000 0.906 0.094
M25.05 Haemarthrosis (Pelvic region and thigh)
0.000 0.906 0.094
M25.04 Haemarthrosis (Hand)
0.000 0.906 0.094
M25.03 Haemarthrosis (Forearm)
0.000 0.906 0.094
M25.02 Haemarthrosis (Upper arm)
0.000 0.906 0.094
M25.01 Haemarthrosis (Shoulder region)
0.000 0.906 0.094
M25.00 Haemarthrosis (Multiple sites)
0.000 0.906 0.094
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.000 0.907 0.092
M25.19 Fistula of joint (Site unspecified)
0.000 0.909 0.091
M25.18 Fistula of joint (Other)
0.000 0.909 0.091
M25.17 Fistula of joint (Ankle and foot)
0.000 0.909 0.091
M25.16 Fistula of joint (Lower leg)
0.000 0.909 0.091
M25.15 Fistula of joint (Pelvic region and thigh)
0.000 0.909 0.091
M25.14 Fistula of joint (Hand)
0.000 0.909 0.091
M25.13 Fistula of joint (Forearm)
0.000 0.909 0.091
M25.12 Fistula of joint (Upper arm)
0.000 0.909 0.091
M25.11 Fistula of joint (Shoulder region)
0.000 0.909 0.091
M25.10 Fistula of joint (Multiple sites)
0.000 0.909 0.091
M25.29 Flail joint (Site unspecified)
0.000 0.909 0.091
M25.28 Flail joint (Other)
0.000 0.909 0.091
M25.27 Flail joint (Ankle and foot)
0.000 0.909 0.091
M25.26 Flail joint (Lower leg)
0.000 0.909 0.091
M25.25 Flail joint (Pelvic region and thigh)
0.000 0.909 0.091
M25.24 Flail joint (Hand)
0.000 0.909 0.091
M25.23 Flail joint (Forearm)
0.000 0.909 0.091
M25.22 Flail joint (Upper arm)
0.000 0.909 0.091
M25.21 Flail joint (Shoulder region)
0.000 0.909 0.091
M25.20 Flail joint (Multiple sites)
0.000 0.909 0.091
S02.4 Fracture of malar and maxillary bones
0.000 0.910 0.090
R39.2 Extrarenal uraemia
0.090 0.910 0.000
M25.97 Joint disorder, unspecified (Ankle and foot)
0.000 0.911 0.089
I21.0 Acute transmural myocardial infarction of anterior wall
0.087 0.913 0.000
C71 Malignant neoplasm of brain
0.085 0.915 0.000
R39.0 Extravasation of urine
0.084 0.916 0.000
C71.9 Brain, unspecified
0.083 0.917 0.000
C71.2 Temporal lobe
0.082 0.917 0.000
C71.0 Cerebrum, except lobes and ventricles
0.081 0.919 0.000
E66 Obesity
0.000 0.923 0.077
S02 Fracture of skull and facial bones
0.000 0.923 0.077
R39.8 Other and unspecified symptoms and signs involving the urinary system
0.077 0.923 0.000
C71.3 Parietal lobe
0.072 0.928 0.000
S06 Intracranial injury
0.000 0.928 0.072
S00-S09 Injuries to the head
0.000 0.929 0.071
R32 Unspecified urinary incontinence
0.067 0.933 0.000
S02.6 Fracture of mandible
0.000 0.933 0.067
S06.3 Focal brain injury
0.000 0.933 0.067
K90-K93 Other diseases of the digestive system
0.000 0.934 0.066
M25.3 Other instability of joint
0.000 0.935 0.065
S02.41 Fracture of malar and maxillary bones (open)
0.000 0.935 0.065
S06.0 Concussion
0.000 0.935 0.065
S06.30 Focal brain injury (without open intracranial wound)
0.000 0.937 0.063
S06.2 Diffuse brain injury
0.000 0.938 0.062
S06.5 Traumatic subdural haemorrhage
0.000 0.938 0.062
S00 Superficial injury of head
0.000 0.939 0.061
C71.7 Brain stem
0.061 0.939 0.000
C71.6 Cerebellum
0.061 0.939 0.000
C71.5 Cerebral ventricle
0.061 0.939 0.000
C71.8 Overlapping lesion of brain
0.061 0.939 0.000
S05 Injury of eye and orbit
0.000 0.940 0.060
S02.60 Fracture of mandible (closed)
0.000 0.940 0.060
S06.00 Concussion (without open intracranial wound)
0.000 0.940 0.060
M25.8 Other specified joint disorders
0.000 0.940 0.060
S00.1 Contusion of eyelid and periocular area
0.000 0.941 0.059
S02.9 Fracture of skull and facial bones, part unspecified
0.000 0.942 0.058
E04.2 Non-toxic multinodular goitre
0.000 0.942 0.058
C71.4 Occipital lobe
0.057 0.943 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.944 0.056
S09 Other and unspecified injuries of head
0.000 0.944 0.056
E66.1 Drug-induced obesity
0.000 0.944 0.055
S06.20 Diffuse brain injury (without open intracranial wound)
0.000 0.944 0.055
S09.8 Other specified injuries of head
0.000 0.944 0.055
M45-M49 Spondylopathies
0.055 0.945 0.000
S06.50 Traumatic subdural haemorrhage (without open intracranial wound)
0.000 0.946 0.054
S02.3 Fracture of orbital floor
0.000 0.947 0.053
S06.4 Epidural haemorrhage
0.000 0.947 0.053
S06.6 Traumatic subarachnoid haemorrhage
0.000 0.947 0.053
I21.4 Acute subendocardial myocardial infarction
0.053 0.947 0.000
S02.5 Fracture of tooth
0.000 0.948 0.052
S02.7 Multiple fractures involving skull and facial bones
0.000 0.948 0.052
S06.7 Intracranial injury with prolonged coma
0.000 0.948 0.052
S05.8 Other injuries of eye and orbit
0.000 0.948 0.052
S02.0 Fracture of vault of skull
0.000 0.948 0.051
S02.8 Fractures of other skull and facial bones
0.000 0.948 0.051
S05.9 Injury of eye and orbit, part unspecified
0.000 0.949 0.051
S08 Traumatic amputation of part of head
0.000 0.949 0.051
S07 Crushing injury of head
0.000 0.949 0.051
S04 Injury of cranial nerves
0.000 0.949 0.051

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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