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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs396243
log Bayes Factor = 28.237
Chromosome 6   position 31,275,174  (GRCh37) Explore rs396243 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
L40.0 Psoriasis vulgaris
0.000 0.054 0.946
E03 Other hypothyroidism
0.608 0.281 0.111
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.3 Pustulosis palmaris et plantaris
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.314 0.686
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.349 0.651
E05 Thyrotoxicosis [hyperthyroidism]
0.001 0.355 0.645
E00-E07 Disorders of thyroid gland
0.017 0.388 0.595
E05.9 Thyrotoxicosis, unspecified
0.000 0.398 0.602
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.417 0.583
E10 Insulin-dependent diabetes mellitus
0.000 0.424 0.576
E10-E14 Diabetes mellitus
0.000 0.427 0.573
E50-E64 Other nutritional deficiencies
0.000 0.430 0.570
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.510 0.433 0.057
E10.3 With ophthalmic complications
0.000 0.450 0.550
L40.8 Other psoriasis
0.000 0.456 0.544
E65-E68 Obesity and other hyperalimentation
0.000 0.464 0.536
E55 Vitamin D deficiency
0.000 0.467 0.533
E06 Thyroiditis
0.006 0.467 0.527
E05.8 Other thyrotoxicosis
0.001 0.468 0.531
E53 Deficiency of other B group vitamins
0.000 0.471 0.529
E10.1 With ketoacidosis
0.000 0.473 0.527
E10.2 With renal complications
0.000 0.474 0.526
E03.5 Myxoedema coma
0.436 0.484 0.080
E03.4 Atrophy of thyroid (acquired)
0.436 0.484 0.080
E03.3 Postinfectious hypothyroidism
0.436 0.484 0.080
E03.1 Congenital hypothyroidism without goitre
0.436 0.484 0.080
E03.0 Congenital hypothyroidism with diffuse goitre
0.436 0.484 0.080
E55.9 Vitamin D deficiency, unspecified
0.000 0.493 0.507
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.511 0.489
E66 Obesity
0.000 0.513 0.487
E03.8 Other specified hypothyroidism
0.414 0.515 0.071
E53.8 Deficiency of other specified B group vitamins
0.000 0.516 0.484
E06.9 Thyroiditis, unspecified
0.002 0.531 0.467
E10.8 With unspecified complications
0.000 0.535 0.465
E05.5 Thyroid crisis or storm
0.001 0.537 0.462
E05.4 Thyrotoxicosis factitia
0.001 0.537 0.462
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.001 0.537 0.462
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.001 0.537 0.462
E66.8 Other obesity
0.000 0.556 0.444
E40-E46 Malnutrition
0.000 0.561 0.439
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.012 0.561 0.427
E00 Congenital iodine-deficiency syndrome
0.012 0.561 0.427
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.563 0.437
E10.9 Without complications
0.000 0.564 0.436
E53.9 Vitamin B deficiency, unspecified
0.000 0.566 0.434
E65 Localised adiposity
0.000 0.567 0.433
E10.4 With neurological complications
0.000 0.573 0.427
E02 Subclinical iodine-deficiency hypothyroidism
0.012 0.578 0.410
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.579 0.421
E10.5 With peripheral circulatory complications
0.000 0.580 0.420
E10.7 With multiple complications
0.000 0.587 0.413
E12 Malnutrition-related diabetes mellitus
0.000 0.589 0.411
E61 Deficiency of other nutrient elements
0.000 0.589 0.411
E51 Thiamine deficiency
0.000 0.590 0.410
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.591 0.408
E63 Other nutritional deficiencies
0.000 0.591 0.408
E50 Vitamin A deficiency
0.000 0.591 0.408
E60 Dietary zinc deficiency
0.000 0.591 0.408
E59 Dietary selenium deficiency
0.000 0.591 0.408
E58 Dietary calcium deficiency
0.000 0.591 0.408
E54 Ascorbic acid deficiency
0.000 0.591 0.408
E52 Niacin deficiency [pellagra]
0.000 0.591 0.408
E06.3 Autoimmune thyroiditis
0.002 0.594 0.404
E66.0 Obesity due to excess calories
0.000 0.599 0.401
E10.6 With other specified complications
0.000 0.603 0.397
E56 Other vitamin deficiencies
0.000 0.614 0.386
E67 Other hyperalimentation
0.000 0.615 0.385
E68 Sequelae of hyperalimentation
0.000 0.615 0.385
E55.0 Rickets, active
0.000 0.618 0.382
E06.5 Other chronic thyroiditis
0.004 0.618 0.378
E06.4 Drug-induced thyroiditis
0.004 0.618 0.378
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.004 0.618 0.378
E06.1 Subacute thyroiditis
0.004 0.618 0.378
E06.0 Acute thyroiditis
0.004 0.618 0.378
E53.1 Pyridoxine deficiency
0.000 0.620 0.379
E53.0 Riboflavin deficiency
0.000 0.620 0.379
E11 Non-insulin-dependent diabetes mellitus
0.000 0.643 0.357
E66.1 Drug-induced obesity
0.000 0.650 0.349
E10.0 With coma
0.000 0.651 0.349
E46 Unspecified protein-energy malnutrition
0.000 0.664 0.336
E13 Other specified diabetes mellitus
0.000 0.668 0.332
E14 Unspecified diabetes mellitus
0.000 0.678 0.322
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.685 0.315
E45 Retarded development following protein-energy malnutrition
0.000 0.685 0.315
E43 Unspecified severe protein-energy malnutrition
0.000 0.685 0.315
E42 Marasmic kwashiorkor
0.000 0.685 0.315
E41 Nutritional marasmus
0.000 0.685 0.315
E40 Kwashiorkor
0.000 0.685 0.315
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.009 0.685 0.306
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.009 0.685 0.306
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.009 0.685 0.306
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.009 0.685 0.306
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.009 0.685 0.306
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.009 0.685 0.306
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.009 0.685 0.306
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.009 0.685 0.306
K90 Intestinal malabsorption
0.000 0.687 0.313
E61.2 Magnesium deficiency
0.000 0.691 0.309
E16 Other disorders of pancreatic internal secretion
0.000 0.695 0.305
L40-L45 Papulosquamous disorders
0.000 0.695 0.305
E15 Nondiabetic hypoglycaemic coma
0.000 0.698 0.302
E51.2 Wernicke's encephalopathy
0.000 0.704 0.295
E12.9 Without complications
0.000 0.705 0.295
E12.8 With unspecified complications
0.000 0.705 0.295
E12.7 With multiple complications
0.000 0.705 0.295
E12.6 With other specified complications
0.000 0.705 0.295
E12.5 With peripheral circulatory complications
0.000 0.705 0.295
E12.4 With neurological complications
0.000 0.705 0.295
E12.3 With ophthalmic complications
0.000 0.705 0.295
E12.2 With renal complications
0.000 0.705 0.295
E12.1 With ketoacidosis
0.000 0.705 0.295
E12.0 With coma
0.000 0.705 0.295
E61.9 Deficiency of nutrient element, unspecified
0.000 0.705 0.294
E61.8 Deficiency of other specified nutrient elements
0.000 0.705 0.294
E61.7 Deficiency of multiple nutrient elements
0.000 0.705 0.294
E61.6 Vanadium deficiency
0.000 0.705 0.294
E61.5 Molybdenum deficiency
0.000 0.705 0.294
E61.4 Chromium deficiency
0.000 0.705 0.294
E61.3 Manganese deficiency
0.000 0.705 0.294
E61.0 Copper deficiency
0.000 0.705 0.294
E51.9 Thiamine deficiency, unspecified
0.000 0.706 0.294
E51.8 Other manifestations of thiamine deficiency
0.000 0.706 0.294
E51.1 Beriberi
0.000 0.706 0.294
E50.9 Vitamin A deficiency, unspecified
0.000 0.707 0.293
E50.8 Other manifestations of vitamin A deficiency
0.000 0.707 0.293
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.707 0.293
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.707 0.293
E50.5 Vitamin A deficiency with night blindness
0.000 0.707 0.293
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.707 0.293
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.707 0.293
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.707 0.293
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.707 0.293
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.707 0.293
E63.9 Nutritional deficiency, unspecified
0.000 0.707 0.293
E63.8 Other specified nutritional deficiencies
0.000 0.707 0.293
E63.1 Imbalance of constituents of food intake
0.000 0.707 0.293
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.707 0.293
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.707 0.293
E64.8 Sequelae of other nutritional deficiencies
0.000 0.707 0.293
E64.3 Sequelae of rickets
0.000 0.707 0.293
E64.2 Sequelae of vitamin C deficiency
0.000 0.707 0.293
E64.1 Sequelae of vitamin A deficiency
0.000 0.707 0.293
E64.0 Sequelae of protein-energy malnutrition
0.000 0.707 0.293
E11.4 With neurological complications
0.000 0.716 0.284
E11.3 With ophthalmic complications
0.000 0.718 0.282
E61.1 Iron deficiency
0.000 0.719 0.281
E56.9 Vitamin deficiency, unspecified
0.000 0.723 0.276
E56.8 Deficiency of other vitamins
0.000 0.723 0.276
E56.0 Deficiency of vitamin E
0.000 0.723 0.276
E67.8 Other specified hyperalimentation
0.000 0.724 0.276
E67.3 Hypervitaminosis D
0.000 0.724 0.276
E67.2 Megavitamin-B6 syndrome
0.000 0.724 0.276
E67.1 Hypercarotenaemia
0.000 0.724 0.276
E67.0 Hypervitaminosis A
0.000 0.724 0.276
E04 Other non-toxic goitre
0.002 0.732 0.266
E14.3 With ophthalmic complications
0.000 0.734 0.266
E11.1 With ketoacidosis
0.000 0.742 0.258
E11.7 With multiple complications
0.000 0.744 0.256
E56.1 Deficiency of vitamin K
0.000 0.746 0.254
E14.8 With unspecified complications
0.000 0.747 0.253
E11.5 With peripheral circulatory complications
0.000 0.748 0.252
E11.8 With unspecified complications
0.000 0.749 0.251
E11.0 With coma
0.000 0.750 0.249
E11.6 With other specified complications
0.000 0.751 0.248
E16.2 Hypoglycaemia, unspecified
0.000 0.752 0.248
E14.1 With ketoacidosis
0.000 0.759 0.241
E13.8 With unspecified complications
0.000 0.762 0.238
E13.7 With multiple complications
0.000 0.762 0.238
E13.6 With other specified complications
0.000 0.762 0.238
E13.5 With peripheral circulatory complications
0.000 0.762 0.238
E13.4 With neurological complications
0.000 0.762 0.238
E13.3 With ophthalmic complications
0.000 0.762 0.238
E13.2 With renal complications
0.000 0.762 0.238
E13.1 With ketoacidosis
0.000 0.762 0.238
E13.0 With coma
0.000 0.762 0.238
E07 Other disorders of thyroid
0.015 0.768 0.217
E14.7 With multiple complications
0.000 0.769 0.231
E14.2 Withrenal complications
0.000 0.769 0.231
E14.0 With coma
0.000 0.769 0.231
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.769 0.231
E11.2 With renal complications
0.000 0.769 0.231
E44.1 Mild protein-energy malnutrition
0.000 0.774 0.226
E44.0 Moderate protein-energy malnutrition
0.000 0.774 0.226
K90.3 Pancreatic steatorrhoea
0.000 0.775 0.225
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.775 0.225
K90.1 Tropical sprue
0.000 0.775 0.225
E14.5 With peripheral circulatory complications
0.000 0.779 0.221
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.781 0.219
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.781 0.219
E16.4 Abnormal secretion of gastrin
0.000 0.781 0.219
E16.3 Increased secretion of glucagon
0.000 0.781 0.219
L44 Other papulosquamous disorders
0.000 0.781 0.219
L41 Parapsoriasis
0.000 0.781 0.219
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.781 0.219
E14.6 With other specified complications
0.000 0.785 0.215
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.786 0.213
L42 Pityriasis rosea
0.000 0.791 0.209
E14.4 With neurological complications
0.000 0.794 0.206
E04.0 Non-toxic diffuse goitre
0.001 0.797 0.202
K90.9 Intestinal malabsorption, unspecified
0.000 0.804 0.196
E04.8 Other specified non-toxic goitre
0.001 0.808 0.191
K90.8 Other intestinal malabsorption
0.000 0.809 0.190
E16.1 Other hypoglycaemia
0.000 0.811 0.189
L43 Lichen planus
0.000 0.822 0.178
E11.9 Without complications
0.000 0.833 0.167
E07.1 Dyshormogenetic goitre
0.011 0.834 0.155
E07.0 Hypersecretion of calcitonin
0.011 0.834 0.155
E04.1 Non-toxic single thyroid nodule
0.000 0.836 0.163
E13.9 Without complications
0.000 0.841 0.159
L41.9 Parapsoriasis, unspecified
0.000 0.843 0.157
L41.8 Other parapsoriasis
0.000 0.843 0.157
L41.5 Retiform parapsoriasis
0.000 0.843 0.157
L41.4 Large plaque parapsoriasis
0.000 0.843 0.157
L41.3 Small plaque parapsoriasis
0.000 0.843 0.157
L41.2 Lymphomatoid papulosis
0.000 0.843 0.157
L41.1 Pityriasis lichenoides chronica
0.000 0.843 0.157
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.843 0.157
L44.9 Papulosquamous disorder, unspecified
0.000 0.843 0.157
L44.8 Other specified papulosquamous disorders
0.000 0.843 0.157
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.843 0.157
L44.3 Lichen ruber moniliformis
0.000 0.843 0.157
L44.2 Lichen striatus
0.000 0.843 0.157
L44.1 Lichen nitidus
0.000 0.843 0.157
L44.0 Pityriasis rubra pilaris
0.000 0.843 0.157
E04.9 Non-toxic goitre, unspecified
0.000 0.857 0.142
E04.2 Non-toxic multinodular goitre
0.000 0.858 0.142
E07.8 Other specified disorders of thyroid
0.012 0.867 0.121
L43.3 Subacute (active) lichen planus
0.000 0.872 0.128
L43.2 Lichenoid drug reaction
0.000 0.872 0.128
L43.1 Bullous lichen planus
0.000 0.872 0.128
L43.0 Hypertrophic lichen planus
0.000 0.872 0.128
L43.8 Other lichen planus
0.000 0.878 0.122
L43.9 Lichen planus, unspecified
0.000 0.904 0.096
G35 Multiple sclerosis
0.000 0.934 0.066
E14.9 Without complications
0.000 0.934 0.066
E20-E35 Disorders of other endocrine glands
0.000 0.937 0.063
E07.9 Disorder of thyroid, unspecified
0.013 0.944 0.042
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.951 0.049
E26 Hyperaldosteronism
0.000 0.953 0.047
G37 Other demyelinating diseases of central nervous system
0.000 0.953 0.047
E27 Other disorders of adrenal gland
0.000 0.955 0.045
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.955 0.045
E32 Diseases of thymus
0.000 0.955 0.045
E31 Polyglandular dysfunction
0.000 0.955 0.045
E30 Disorders of puberty, not elsewhere classified
0.000 0.955 0.045
E25 Adrenogenital disorders
0.000 0.955 0.045
E20 Hypoparathyroidism
0.000 0.956 0.043
E22 Hyperfunction of pituitary gland
0.000 0.957 0.043
E34 Other endocrine disorders
0.000 0.957 0.042
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.959 0.041
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.960 0.040
E24 Cushing's syndrome
0.000 0.960 0.040
E27.1 Primary adrenocortical insufficiency
0.000 0.960 0.040
E29 Testicular dysfunction
0.000 0.960 0.039
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.963 0.037
E27.8 Other specified disorders of adrenal gland
0.000 0.964 0.036
E26.0 Primary hyperaldosteronism
0.000 0.965 0.035
E34.0 Carcinoid syndrome
0.000 0.965 0.035
G36 Other acute disseminated demyelination
0.000 0.965 0.035
E22.1 Hyperprolactinaemia
0.000 0.966 0.034
E26.9 Hyperaldosteronism, unspecified
0.000 0.966 0.034
E26.8 Other hyperaldosteronism
0.000 0.966 0.034
E26.1 Secondary hyperaldosteronism
0.000 0.966 0.034
G37.5 Concentric sclerosis [Balo]
0.000 0.966 0.034
G37.4 Subacute necrotising myelitis
0.000 0.966 0.034
G37.2 Central pontine myelinolysis
0.000 0.966 0.034
G37.1 Central demyelination of corpus callosum
0.000 0.966 0.034
G37.0 Diffuse sclerosis
0.000 0.966 0.034
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.967 0.033
E27.5 Adrenomedullary hyperfunction
0.000 0.967 0.033
E27.0 Other adrenocortical overactivity
0.000 0.967 0.033
E25.9 Adrenogenital disorder, unspecified
0.000 0.967 0.032
E25.8 Other adrenogenital disorders
0.000 0.967 0.032
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.967 0.032
E30.9 Disorder of puberty, unspecified
0.000 0.967 0.032
E30.8 Other disorders of puberty
0.000 0.967 0.032
E30.1 Precocious puberty
0.000 0.967 0.032
E30.0 Delayed puberty
0.000 0.967 0.032
E31.9 Polyglandular dysfunction, unspecified
0.000 0.967 0.032
E31.8 Other polyglandular dysfunction
0.000 0.967 0.032
E31.1 Polyglandular hyperfunction
0.000 0.967 0.032
E31.0 Autoimmune polyglandular failure
0.000 0.967 0.032
E32.9 Disease of thymus, unspecified
0.000 0.967 0.032
E32.8 Other diseases of thymus
0.000 0.967 0.032
E32.1 Abscess of thymus
0.000 0.967 0.032
E32.0 Persistent hyperplasia of thymus
0.000 0.967 0.032
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.967 0.032
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.967 0.032
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.967 0.032
M25.55 Pain in joint (Pelvic region and thigh)
0.000 0.967 0.033
E22.0 Acromegaly and pituitary gigantism
0.000 0.968 0.032
M25.5 Pain in joint
0.000 0.968 0.032
E20.8 Other hypoparathyroidism
0.000 0.969 0.031
E20.1 Pseudohypoparathyroidism
0.000 0.969 0.031
E20.0 Idiopathic hypoparathyroidism
0.000 0.969 0.031
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.969 0.031
E22.8 Other hyperfunction of pituitary gland
0.000 0.969 0.031
E34.5 Androgen resistance syndrome
0.000 0.969 0.031
E34.4 Constitutional tall stature
0.000 0.969 0.031
E34.3 Short stature, not elsewhere classified
0.000 0.969 0.031
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.969 0.031
E34.1 Other hypersecretion of intestinal hormones
0.000 0.969 0.031
M25.54 Pain in joint (Hand)
0.000 0.970 0.030
E24.0 Pituitary-dependent Cushing's disease
0.000 0.970 0.030
E27.2 Addisonian crisis
0.000 0.970 0.030
E20.9 Hypoparathyroidism, unspecified
0.000 0.970 0.029
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.971 0.029
E24.8 Other Cushing's syndrome
0.000 0.971 0.029
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.971 0.029
E24.3 Ectopic ACTH syndrome
0.000 0.971 0.029
E24.1 Nelson's syndrome
0.000 0.971 0.029
M25.59 Pain in joint (Site unspecified)
0.000 0.971 0.029
E29.9 Testicular dysfunction, unspecified
0.000 0.971 0.028
E29.8 Other testicular dysfunction
0.000 0.971 0.028
E29.0 Testicular hyperfunction
0.000 0.971 0.028
M25.50 Pain in joint (Multiple sites)
0.000 0.972 0.028
D70 Agranulocytosis
0.000 0.972 0.028
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.972 0.028
E24.2 Drug-induced Cushing's syndrome
0.000 0.972 0.027
D75 Other diseases of blood and blood-forming organs
0.000 0.973 0.027
E27.9 Disorder of adrenal gland, unspecified
0.000 0.973 0.026
E34.9 Endocrine disorder, unspecified
0.000 0.974 0.026
D72 Other disorders of white blood cells
0.000 0.974 0.026
M25.51 Pain in joint (Shoulder region)
0.000 0.974 0.026
E34.8 Other specified endocrine disorders
0.000 0.974 0.025
D72.8 Other specified disorders of white blood cells
0.000 0.975 0.025
G36.9 Acute disseminated demyelination, unspecified
0.000 0.975 0.025
G36.8 Other specified acute disseminated demyelination
0.000 0.975 0.025
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.975 0.025
G36.0 Neuromyelitis optica [Devic]
0.000 0.975 0.024
E28 Ovarian dysfunction
0.002 0.976 0.023
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.976 0.024
E24.9 Cushing's syndrome, unspecified
0.000 0.976 0.024
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.976 0.024
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.976 0.024
K90-K93 Other diseases of the digestive system
0.000 0.977 0.023
M25.52 Pain in joint (Upper arm)
0.000 0.977 0.023
M25.58 Pain in joint (Other)
0.000 0.977 0.023
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.977 0.023
E29.1 Testicular hypofunction
0.000 0.977 0.023
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.977 0.022
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.978 0.022
E21.0 Primary hyperparathyroidism
0.000 0.978 0.022
M07.3 Other psoriatic arthropathies
0.000 0.978 0.022
D75.2 Essential thrombocytosis
0.000 0.978 0.022
E23 Hypofunction and other disorders of pituitary gland
0.000 0.979 0.021
E21.4 Other specified disorders of parathyroid gland
0.000 0.979 0.021
E21.2 Other hyperparathyroidism
0.000 0.979 0.021
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.979 0.021
M25.53 Pain in joint (Forearm)
0.000 0.979 0.021
D75.1 Secondary polycythaemia
0.000 0.979 0.021
D74 Methaemoglobinaemia
0.000 0.980 0.020
D73 Diseases of spleen
0.000 0.980 0.020
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.980 0.020
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.980 0.020
M25.57 Pain in joint (Ankle and foot)
0.000 0.980 0.020
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.980 0.020
D75.0 Familial erythrocytosis
0.000 0.980 0.019
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.981 0.019
D72.9 Disorder of white blood cells, unspecified
0.000 0.981 0.019
D72.0 Genetic anomalies of leukocytes
0.000 0.981 0.019
D72.1 Eosinophilia
0.000 0.981 0.019
D86 Sarcoidosis
0.000 0.981 0.019
S64.4 Injury of digital nerve of other finger
0.019 0.981 0.000
D86.9 Sarcoidosis, unspecified
0.000 0.982 0.018
E28.9 Ovarian dysfunction, unspecified
0.001 0.982 0.016
E28.8 Other ovarian dysfunction
0.001 0.982 0.016
E28.1 Androgen excess
0.001 0.982 0.016
E28.0 Oestrogen excess
0.001 0.982 0.016
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.000 0.982 0.018
D86.1 Sarcoidosis of lymph nodes
0.000 0.983 0.017
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.983 0.017
D86.0 Sarcoidosis of lung
0.000 0.983 0.017
D73.0 Hyposplenism
0.000 0.983 0.016
D86.8 Sarcoidosis of other and combined sites
0.000 0.984 0.016
M07.38 Other psoriatic arthropathies (Other)
0.000 0.984 0.016
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.984 0.016
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.984 0.016
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.984 0.016
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.984 0.016
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.984 0.016
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.984 0.016
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.984 0.016
D73.1 Hypersplenism
0.000 0.984 0.015
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.984 0.015
E23.1 Drug-induced hypopituitarism
0.000 0.984 0.015
E23.7 Disorder of pituitary gland, unspecified
0.000 0.984 0.015
D73.8 Other diseases of spleen
0.000 0.985 0.015
D74.9 Methaemoglobinaemia, unspecified
0.000 0.985 0.015
D74.8 Other methaemoglobinaemias
0.000 0.985 0.015
D74.0 Congenital methaemoglobinaemia
0.000 0.985 0.015
D73.9 Disease of spleen, unspecified
0.000 0.985 0.015
D73.3 Abscess of spleen
0.000 0.985 0.015
D73.2 Chronic congestive splenomegaly
0.000 0.985 0.015
E28.3 Primary ovarian failure
0.001 0.985 0.013
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.986 0.014
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.986 0.014
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.986 0.014
D80-D89 Certain disorders involving the immune mechanism
0.000 0.986 0.014
I26 Pulmonary embolism
0.000 0.986 0.014
D76.3 Other histiocytosis syndromes
0.000 0.986 0.014
E23.6 Other disorders of pituitary gland
0.000 0.986 0.013
D86.3 Sarcoidosis of skin
0.000 0.986 0.014
D73.5 Infarction of spleen
0.000 0.986 0.013
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.986 0.014
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.987 0.013
M25 Other joint disorders, not elsewhere classified
0.000 0.987 0.013
I27.9 Pulmonary heart disease, unspecified
0.000 0.987 0.013
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)
0.000 0.987 0.013
I27 Other pulmonary heart diseases
0.000 0.987 0.013
M25.9 Joint disorder, unspecified
0.000 0.988 0.012
M25.6 Stiffness of joint, not elsewhere classified
0.000 0.988 0.012
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.988 0.012
K93.1 Megacolon in Chagas' disease
0.000 0.988 0.012
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.988 0.012
D73.4 Cyst of spleen
0.000 0.988 0.012
I27.0 Primary pulmonary hypertension
0.000 0.988 0.012
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.988 0.012
M25.96 Joint disorder, unspecified (Lower leg)
0.000 0.989 0.011
M25.94 Joint disorder, unspecified (Hand)
0.000 0.989 0.011
D82 Immunodeficiency associated with other major defects
0.000 0.990 0.010
D81 Combined immunodeficiencies
0.000 0.990 0.010
S64 Injury of nerves at wrist and hand level
0.010 0.990 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.990 0.010
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.000 0.990 0.010
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.990 0.010
S82.80 Fractures of other parts of lower leg (closed)
0.010 0.990 0.000
D83 Common variable immunodeficiency
0.000 0.990 0.010
M25.97 Joint disorder, unspecified (Ankle and foot)
0.000 0.990 0.010
E23.2 Diabetes insipidus
0.001 0.990 0.010
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)
0.000 0.990 0.010
J98.4 Other disorders of lung
0.010 0.990 0.000
M25.91 Joint disorder, unspecified (Shoulder region)
0.000 0.990 0.010
M25.2 Flail joint
0.000 0.990 0.010
M25.1 Fistula of joint
0.000 0.990 0.010
E23.0 Hypopituitarism
0.000 0.990 0.009
M07 Psoriatic and enteropathic arthropathies
0.000 0.991 0.009
M25.84 Other specified joint disorders (Hand)
0.000 0.991 0.009
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.000 0.991 0.009
M25.8 Other specified joint disorders
0.000 0.991 0.009
I27.1 Kyphoscoliotic heart disease
0.000 0.991 0.009
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)
0.000 0.991 0.009
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)
0.000 0.991 0.009
S64.0 Injury of ulnar nerve at wrist and hand level
0.009 0.991 0.000
M25.99 Joint disorder, unspecified (Site unspecified)
0.000 0.991 0.009
M25.98 Joint disorder, unspecified (Other)
0.000 0.991 0.009
M25.93 Joint disorder, unspecified (Forearm)
0.000 0.991 0.009
M25.92 Joint disorder, unspecified (Upper arm)
0.000 0.991 0.009
M25.90 Joint disorder, unspecified (Multiple sites)
0.000 0.991 0.009
I84.9 Unspecified haemorrhoids without complication
0.009 0.991 0.000
D84 Other immunodeficiencies
0.000 0.991 0.009
I28 Other diseases of pulmonary vessels
0.000 0.991 0.009
D55-D59 Haemolytic anaemias
0.000 0.991 0.009
M25.68 Stiffness of joint, not elsewhere classified (Other)
0.000 0.991 0.009
M25.0 Haemarthrosis
0.000 0.991 0.009
D66 Hereditary factor VIII deficiency
0.000 0.991 0.009
S64.7 Injury of multiple nerves at wrist and hand level
0.008 0.991 0.000
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)
0.000 0.992 0.008
M25.64 Stiffness of joint, not elsewhere classified (Hand)
0.000 0.992 0.008
M25.63 Stiffness of joint, not elsewhere classified (Forearm)
0.000 0.992 0.008
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)
0.000 0.992 0.008
M25.95 Joint disorder, unspecified (Pelvic region and thigh)
0.000 0.992 0.008
D89.1 Cryoglobulinaemia
0.000 0.992 0.008
M25.77 Osteophyte (Ankle and foot)
0.000 0.992 0.008
D81.9 Combined immunodeficiency, unspecified
0.000 0.992 0.007
D81.8 Other combined immunodeficiencies
0.000 0.992 0.007
D81.7 Major histocompatibility complex class II deficiency
0.000 0.992 0.007
D81.6 Major histocompatibility complex class I deficiency
0.000 0.992 0.007
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.992 0.007
D81.4 Nezelof's syndrome
0.000 0.992 0.007
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.992 0.007
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.992 0.007
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.992 0.007
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.992 0.007
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.992 0.007
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.992 0.007
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.992 0.007
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.992 0.007
D82.2 Immunodeficiency with short-limbed stature
0.000 0.992 0.007
D82.1 Di George's syndrome
0.000 0.992 0.007
D82.0 Wiskott-Aldrich syndrome
0.000 0.992 0.007
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.992 0.008
S64.9 Injury of unspecified nerve at wrist and hand level
0.008 0.992 0.000
S64.8 Injury of other nerves at wrist and hand level
0.008 0.992 0.000
I27.8 Other specified pulmonary heart diseases
0.000 0.992 0.008
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.992 0.008
D89.3 Immune reconstitution syndrome
0.000 0.992 0.008
I28.8 Other specified diseases of pulmonary vessels
0.000 0.992 0.007
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.992 0.008
D67 Hereditary factor IX deficiency
0.000 0.992 0.007
M25.86 Other specified joint disorders (Lower leg)
0.000 0.992 0.008
D83.8 Other common variable immunodeficiencies
0.000 0.992 0.007
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.992 0.007

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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