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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs404860
log Bayes Factor = 26.6156
Chromosome 6   position 32,184,345  (GRCh37) Explore rs404860 on Ensembl!
Variant rs404860 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
G35 Multiple sclerosis
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.999 0.001 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.002 0.998
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.002 0.998
E10 Insulin-dependent diabetes mellitus
0.000 0.002 0.998
E10-E14 Diabetes mellitus
0.000 0.003 0.997
E00-E07 Disorders of thyroid gland
0.000 0.003 0.997
E05.9 Thyrotoxicosis, unspecified
0.000 0.003 0.997
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.997 0.003 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.011 0.989
E27 Other disorders of adrenal gland
0.000 0.013 0.987
M06 Other rheumatoid arthritis
0.986 0.014 0.000
L40.5 Arthropathic psoriasis
0.000 0.015 0.985
E10.9 Without complications
0.000 0.017 0.983
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.983 0.017 0.000
L40 Psoriasis
0.000 0.017 0.983
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.019 0.981
L40.9 Psoriasis, unspecified
0.000 0.019 0.981
E27.1 Primary adrenocortical insufficiency
0.000 0.021 0.979
E10.3 With ophthalmic complications
0.000 0.029 0.971
E50-E64 Other nutritional deficiencies
0.000 0.039 0.961
M05.9 Seropositive rheumatoid arthritis, unspecified
0.959 0.041 0.000
M05 Seropositive rheumatoid arthritis
0.956 0.044 0.000
M05-M14 Inflammatory polyarthropathies
0.954 0.046 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.945 0.055 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.942 0.058 0.000
E10.2 With renal complications
0.000 0.062 0.938
E55 Vitamin D deficiency
0.000 0.064 0.936
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.928 0.072 0.000
E55.9 Vitamin D deficiency, unspecified
0.000 0.082 0.918
M06.3 Rheumatoid nodule
0.910 0.090 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.905 0.095 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.895 0.105 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.886 0.114 0.000
E10.1 With ketoacidosis
0.000 0.121 0.879
K90 Intestinal malabsorption
0.000 0.136 0.864
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.137 0.863
E27.2 Addisonian crisis
0.000 0.141 0.859
M06.34 Rheumatoid nodule (Hand)
0.839 0.161 0.000
E20 Hypoparathyroidism
0.000 0.163 0.837
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.804 0.195 0.000
E10.6 With other specified complications
0.000 0.196 0.804
K90.9 Intestinal malabsorption, unspecified
0.000 0.201 0.799
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.798 0.202 0.000
L40.0 Psoriasis vulgaris
0.000 0.204 0.796
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.207 0.793
E05.8 Other thyrotoxicosis
0.000 0.211 0.789
E10.5 With peripheral circulatory complications
0.000 0.220 0.780
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.233 0.767
E13 Other specified diabetes mellitus
0.000 0.243 0.757
M05.1 Rheumatoid lung disease
0.757 0.243 0.000
E10.0 With coma
0.000 0.244 0.756
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.754 0.246 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.254 0.746
M06.0 Seronegative rheumatoid arthritis
0.745 0.255 0.000
E10.4 With neurological complications
0.000 0.260 0.740
E65-E68 Obesity and other hyperalimentation
0.000 0.260 0.740
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.736 0.264 0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.733 0.266 0.000
E53 Deficiency of other B group vitamins
0.000 0.271 0.729
E27.8 Other specified disorders of adrenal gland
0.000 0.272 0.728
E20.9 Hypoparathyroidism, unspecified
0.000 0.273 0.727
E23 Hypofunction and other disorders of pituitary gland
0.000 0.282 0.717
M06.32 Rheumatoid nodule (Upper arm)
0.717 0.283 0.000
E05.5 Thyroid crisis or storm
0.000 0.284 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.284 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.284 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.284 0.716
E10.7 With multiple complications
0.000 0.284 0.716
E12 Malnutrition-related diabetes mellitus
0.000 0.285 0.715
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.285 0.715
E00 Congenital iodine-deficiency syndrome
0.000 0.285 0.715
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.285 0.715
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.291 0.709
E32 Diseases of thymus
0.000 0.291 0.709
E31 Polyglandular dysfunction
0.000 0.291 0.709
E30 Disorders of puberty, not elsewhere classified
0.000 0.291 0.709
E27.5 Adrenomedullary hyperfunction
0.000 0.292 0.708
E27.0 Other adrenocortical overactivity
0.000 0.292 0.708
M06.8 Other specified rheumatoid arthritis
0.707 0.293 0.000
M06.2 Rheumatoid bursitis
0.707 0.293 0.000
M06.1 Adult-onset Still's disease
0.707 0.293 0.000
M12 Other specific arthropathies
0.706 0.294 0.000
L40.4 Guttate psoriasis
0.000 0.295 0.704
L40.3 Pustulosis palmaris et plantaris
0.000 0.295 0.704
L40.2 Acrodermatitis continua
0.000 0.295 0.704
L40.1 Generalised pustular psoriasis
0.000 0.295 0.704
M05.8 Other seropositive rheumatoid arthritis
0.699 0.301 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.307 0.693
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.690 0.310 0.000
E25 Adrenogenital disorders
0.000 0.311 0.689
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.311 0.689
E63 Other nutritional deficiencies
0.000 0.311 0.689
E56 Other vitamin deficiencies
0.000 0.311 0.689
E51 Thiamine deficiency
0.000 0.311 0.689
E50 Vitamin A deficiency
0.000 0.311 0.689
E60 Dietary zinc deficiency
0.000 0.311 0.689
E59 Dietary selenium deficiency
0.000 0.311 0.689
E58 Dietary calcium deficiency
0.000 0.311 0.689
E54 Ascorbic acid deficiency
0.000 0.311 0.689
E52 Niacin deficiency [pellagra]
0.000 0.311 0.689
L40.8 Other psoriasis
0.000 0.312 0.688
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.687 0.313 0.000
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.687 0.313 0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.687 0.313 0.000
E24 Cushing's syndrome
0.000 0.313 0.687
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.685 0.314 0.000
M05.2 Rheumatoid vasculitis
0.685 0.314 0.000
M05.0 Felty's syndrome
0.685 0.314 0.000
E27.9 Disorder of adrenal gland, unspecified
0.000 0.316 0.684
E06 Thyroiditis
0.000 0.316 0.684
M09 Juvenile arthritis in diseases classified elsewhere
0.684 0.316 0.000
M08 Juvenile arthritis
0.684 0.316 0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.673 0.326 0.000
M11 Other crystal arthropathies
0.673 0.327 0.000
E55.0 Rickets, active
0.000 0.329 0.671
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.669 0.331 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.668 0.332 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.340 0.660
E22 Hyperfunction of pituitary gland
0.000 0.342 0.658
M06.39 Rheumatoid nodule (Site unspecified)
0.653 0.347 0.000
M06.38 Rheumatoid nodule (Other)
0.653 0.347 0.000
M06.36 Rheumatoid nodule (Lower leg)
0.653 0.347 0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.653 0.347 0.000
M06.33 Rheumatoid nodule (Forearm)
0.653 0.347 0.000
M06.31 Rheumatoid nodule (Shoulder region)
0.653 0.347 0.000
E26 Hyperaldosteronism
0.000 0.348 0.652
G37 Other demyelinating diseases of central nervous system
0.000 0.348 0.652
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.352 0.648
L40-L45 Papulosquamous disorders
0.000 0.353 0.647
E29 Testicular dysfunction
0.000 0.353 0.647
K90.8 Other intestinal malabsorption
0.000 0.356 0.644
M06.4 Inflammatory polyarthropathy
0.641 0.359 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.634 0.366 0.000
E61 Deficiency of other nutrient elements
0.000 0.378 0.622
K90.3 Pancreatic steatorrhoea
0.000 0.380 0.620
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.380 0.620
K90.1 Tropical sprue
0.000 0.380 0.620
M05.19 Rheumatoid lung disease (Site unspecified)
0.614 0.386 0.000
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.613 0.387 0.000
E23.6 Other disorders of pituitary gland
0.000 0.394 0.606
E20.8 Other hypoparathyroidism
0.000 0.400 0.600
E20.1 Pseudohypoparathyroidism
0.000 0.400 0.600
E20.0 Idiopathic hypoparathyroidism
0.000 0.400 0.600
M14 Arthropathies in other diseases classified elsewhere
0.595 0.404 0.000
E13.9 Without complications
0.000 0.415 0.585
E28 Ovarian dysfunction
0.000 0.416 0.584
E10.8 With unspecified complications
0.000 0.421 0.579
E40-E46 Malnutrition
0.000 0.426 0.574
E23.7 Disorder of pituitary gland, unspecified
0.000 0.426 0.574
E53.8 Deficiency of other specified B group vitamins
0.000 0.426 0.574
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.436 0.564
E65 Localised adiposity
0.000 0.443 0.556
G36 Other acute disseminated demyelination
0.000 0.450 0.550
E21.0 Primary hyperparathyroidism
0.000 0.454 0.546
M10 Gout
0.546 0.454 0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.455 0.545
E13.8 With unspecified complications
0.000 0.457 0.543
E13.7 With multiple complications
0.000 0.457 0.543
E13.6 With other specified complications
0.000 0.457 0.543
E13.5 With peripheral circulatory complications
0.000 0.457 0.543
E13.4 With neurological complications
0.000 0.457 0.543
E13.3 With ophthalmic complications
0.000 0.457 0.543
E13.2 With renal complications
0.000 0.457 0.543
E13.1 With ketoacidosis
0.000 0.457 0.543
E13.0 With coma
0.000 0.457 0.543
M05.18 Rheumatoid lung disease (Other)
0.542 0.457 0.000
M05.17 Rheumatoid lung disease (Ankle and foot)
0.542 0.457 0.000
M05.16 Rheumatoid lung disease (Lower leg)
0.542 0.457 0.000
M05.15 Rheumatoid lung disease (Pelvic region and thigh)
0.542 0.457 0.000
M05.14 Rheumatoid lung disease (Hand)
0.542 0.457 0.000
M05.13 Rheumatoid lung disease (Forearm)
0.542 0.457 0.000
M05.12 Rheumatoid lung disease (Upper arm)
0.542 0.457 0.000
M05.11 Rheumatoid lung disease (Shoulder region)
0.542 0.457 0.000
M05.10 Rheumatoid lung disease (Multiple sites)
0.542 0.457 0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.542 0.458 0.000
L71.9 Rosacea, unspecified
0.000 0.460 0.540
M12.3 Palindromic rheumatism
0.536 0.464 0.000
E34 Other endocrine disorders
0.000 0.464 0.536
M06.08 Seronegative rheumatoid arthritis (Other)
0.534 0.465 0.000
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.534 0.465 0.000
M06.04 Seronegative rheumatoid arthritis (Hand)
0.534 0.465 0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.534 0.465 0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.534 0.465 0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.534 0.465 0.000
L71 Rosacea
0.000 0.469 0.531
E67 Other hyperalimentation
0.000 0.470 0.530
E68 Sequelae of hyperalimentation
0.000 0.470 0.530
E66 Obesity
0.000 0.472 0.528
L60-L75 Disorders of skin appendages
0.000 0.474 0.526
E24.2 Drug-induced Cushing's syndrome
0.000 0.475 0.525
L08.9 Local infection of skin and subcutaneous tissue, unspecified
0.000 0.475 0.525
E53.1 Pyridoxine deficiency
0.000 0.477 0.523
E53.0 Riboflavin deficiency
0.000 0.477 0.523
L08 Other local infections of skin and subcutaneous tissue
0.000 0.481 0.519
E06.9 Thyroiditis, unspecified
0.000 0.481 0.519
L00-L08 Infections of the skin and subcutaneous tissue
0.000 0.481 0.519
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.485 0.514
E23.1 Drug-induced hypopituitarism
0.000 0.485 0.514
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)
0.514 0.486 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.514 0.486 0.000
E12.9 Without complications
0.000 0.487 0.513
E12.8 With unspecified complications
0.000 0.487 0.513
E12.7 With multiple complications
0.000 0.487 0.513
E12.6 With other specified complications
0.000 0.487 0.513
E12.5 With peripheral circulatory complications
0.000 0.487 0.513
E12.4 With neurological complications
0.000 0.487 0.513
E12.3 With ophthalmic complications
0.000 0.487 0.513
E12.2 With renal complications
0.000 0.487 0.513
E12.1 With ketoacidosis
0.000 0.487 0.513
E12.0 With coma
0.000 0.487 0.513
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.487 0.512
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.487 0.512
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.487 0.512
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.487 0.512
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.487 0.512
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.487 0.512
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.487 0.512
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.487 0.512
E53.9 Vitamin B deficiency, unspecified
0.000 0.490 0.509
E30.9 Disorder of puberty, unspecified
0.000 0.491 0.508
E30.8 Other disorders of puberty
0.000 0.491 0.508
E30.1 Precocious puberty
0.000 0.491 0.508
E30.0 Delayed puberty
0.000 0.491 0.508
E31.9 Polyglandular dysfunction, unspecified
0.000 0.491 0.508
E31.8 Other polyglandular dysfunction
0.000 0.491 0.508
E31.1 Polyglandular hyperfunction
0.000 0.491 0.508
E31.0 Autoimmune polyglandular failure
0.000 0.491 0.508
E32.9 Disease of thymus, unspecified
0.000 0.491 0.508
E32.8 Other diseases of thymus
0.000 0.491 0.508
E32.1 Abscess of thymus
0.000 0.491 0.508
E32.0 Persistent hyperplasia of thymus
0.000 0.491 0.508
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.491 0.508
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.491 0.508
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.491 0.508
E22.0 Acromegaly and pituitary gigantism
0.000 0.492 0.508
M06.19 Adult-onset Still's disease (Site unspecified)
0.507 0.493 0.000
M06.18 Adult-onset Still's disease (Other)
0.507 0.493 0.000
M06.17 Adult-onset Still's disease (Ankle and foot)
0.507 0.493 0.000
M06.16 Adult-onset Still's disease (Lower leg)
0.507 0.493 0.000
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.507 0.493 0.000
M06.14 Adult-onset Still's disease (Hand)
0.507 0.493 0.000
M06.13 Adult-onset Still's disease (Forearm)
0.507 0.493 0.000
M06.12 Adult-onset Still's disease (Upper arm)
0.507 0.493 0.000
M06.11 Adult-onset Still's disease (Shoulder region)
0.507 0.493 0.000
M06.10 Adult-onset Still's disease (Multiple sites)
0.507 0.493 0.000
M06.29 Rheumatoid bursitis (Site unspecified)
0.507 0.493 0.000
M06.28 Rheumatoid bursitis (Other)
0.507 0.493 0.000
M06.27 Rheumatoid bursitis (Ankle and foot)
0.507 0.493 0.000
M06.26 Rheumatoid bursitis (Lower leg)
0.507 0.493 0.000
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.507 0.493 0.000
M06.24 Rheumatoid bursitis (Hand)
0.507 0.493 0.000
M06.23 Rheumatoid bursitis (Forearm)
0.507 0.493 0.000
M06.22 Rheumatoid bursitis (Upper arm)
0.507 0.493 0.000
M06.21 Rheumatoid bursitis (Shoulder region)
0.507 0.493 0.000
M06.20 Rheumatoid bursitis (Multiple sites)
0.507 0.493 0.000
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.507 0.493 0.000
M06.88 Other specified rheumatoid arthritis (Other)
0.507 0.493 0.000
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.507 0.493 0.000
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.507 0.493 0.000
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.507 0.493 0.000
M06.84 Other specified rheumatoid arthritis (Hand)
0.507 0.493 0.000
M06.83 Other specified rheumatoid arthritis (Forearm)
0.507 0.493 0.000
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.507 0.493 0.000
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.507 0.493 0.000
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.507 0.493 0.000
M12.8 Other specific arthropathies, not elsewhere classified
0.506 0.493 0.000
M12.5 Traumatic arthropathy
0.506 0.493 0.000
M12.4 Intermittent hydrarthrosis
0.506 0.493 0.000
M12.1 Kaschin-Beck disease
0.506 0.493 0.000
M12.0 Chronic postrheumatic arthropathy [Jaccoud]
0.506 0.493 0.000
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.497 0.503
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.502 0.498 0.000
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)
0.501 0.499 0.000
M05.88 Other seropositive rheumatoid arthritis (Other)
0.501 0.499 0.000
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)
0.501 0.499 0.000
M05.86 Other seropositive rheumatoid arthritis (Lower leg)
0.501 0.499 0.000
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)
0.501 0.499 0.000
M05.84 Other seropositive rheumatoid arthritis (Hand)
0.501 0.499 0.000
M05.83 Other seropositive rheumatoid arthritis (Forearm)
0.501 0.499 0.000
M05.82 Other seropositive rheumatoid arthritis (Upper arm)
0.501 0.499 0.000
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)
0.501 0.499 0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.499 0.501 0.000
M12.2 Villonodular synovitis (pigmented)
0.498 0.502 0.000
E15 Nondiabetic hypoglycaemic coma
0.000 0.503 0.497
E25.9 Adrenogenital disorder, unspecified
0.000 0.506 0.494
E25.8 Other adrenogenital disorders
0.000 0.506 0.494
E50.9 Vitamin A deficiency, unspecified
0.000 0.506 0.494
E50.8 Other manifestations of vitamin A deficiency
0.000 0.506 0.494
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.506 0.494
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.506 0.494
E50.5 Vitamin A deficiency with night blindness
0.000 0.506 0.494
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.506 0.494
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.506 0.494
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.506 0.494
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.506 0.494
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.506 0.494
E51.9 Thiamine deficiency, unspecified
0.000 0.506 0.494
E51.8 Other manifestations of thiamine deficiency
0.000 0.506 0.494
E51.2 Wernicke's encephalopathy
0.000 0.506 0.494
E51.1 Beriberi
0.000 0.506 0.494
E56.9 Vitamin deficiency, unspecified
0.000 0.506 0.494
E56.8 Deficiency of other vitamins
0.000 0.506 0.494
E56.1 Deficiency of vitamin K
0.000 0.506 0.494
E56.0 Deficiency of vitamin E
0.000 0.506 0.494
E63.9 Nutritional deficiency, unspecified
0.000 0.506 0.494
E63.8 Other specified nutritional deficiencies
0.000 0.506 0.494
E63.1 Imbalance of constituents of food intake
0.000 0.506 0.494
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.506 0.494
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.506 0.494
E64.8 Sequelae of other nutritional deficiencies
0.000 0.506 0.494
E64.3 Sequelae of rickets
0.000 0.506 0.494
E64.2 Sequelae of vitamin C deficiency
0.000 0.506 0.494
E64.1 Sequelae of vitamin A deficiency
0.000 0.506 0.494
E64.0 Sequelae of protein-energy malnutrition
0.000 0.506 0.494
E24.8 Other Cushing's syndrome
0.000 0.507 0.493
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.507 0.493
E24.3 Ectopic ACTH syndrome
0.000 0.507 0.493
E24.1 Nelson's syndrome
0.000 0.507 0.493
E24.0 Pituitary-dependent Cushing's disease
0.000 0.507 0.493
E07 Other disorders of thyroid
0.000 0.507 0.492
M05.09 Felty's syndrome (Site unspecified)
0.491 0.508 0.000
M05.08 Felty's syndrome (Other)
0.491 0.508 0.000
M05.07 Felty's syndrome (Ankle and foot)
0.491 0.508 0.000
M05.06 Felty's syndrome (Lower leg)
0.491 0.508 0.000
M05.05 Felty's syndrome (Pelvic region and thigh)
0.491 0.508 0.000
M05.04 Felty's syndrome (Hand)
0.491 0.508 0.000
M05.03 Felty's syndrome (Forearm)
0.491 0.508 0.000
M05.02 Felty's syndrome (Upper arm)
0.491 0.508 0.000
M05.01 Felty's syndrome (Shoulder region)
0.491 0.508 0.000
M05.00 Felty's syndrome (Multiple sites)
0.491 0.508 0.000
M05.29 Rheumatoid vasculitis (Site unspecified)
0.491 0.508 0.000
M05.28 Rheumatoid vasculitis (Other)
0.491 0.508 0.000
M05.27 Rheumatoid vasculitis (Ankle and foot)
0.491 0.508 0.000
M05.26 Rheumatoid vasculitis (Lower leg)
0.491 0.508 0.000
M05.25 Rheumatoid vasculitis (Pelvic region and thigh)
0.491 0.508 0.000
M05.24 Rheumatoid vasculitis (Hand)
0.491 0.508 0.000
M05.23 Rheumatoid vasculitis (Forearm)
0.491 0.508 0.000
M05.22 Rheumatoid vasculitis (Upper arm)
0.491 0.508 0.000
M05.21 Rheumatoid vasculitis (Shoulder region)
0.491 0.508 0.000
M05.20 Rheumatoid vasculitis (Multiple sites)
0.491 0.508 0.000
M05.39 Rheumatoid arthritis with involvement of other organs and systems (Site unspecified)
0.491 0.508 0.000
M05.38 Rheumatoid arthritis with involvement of other organs and systems (Other)
0.491 0.508 0.000
M05.37 Rheumatoid arthritis with involvement of other organs and systems (Ankle and foot)
0.491 0.508 0.000
M05.36 Rheumatoid arthritis with involvement of other organs and systems (Lower leg)
0.491 0.508 0.000
M05.35 Rheumatoid arthritis with involvement of other organs and systems (Pelvic region and thigh)
0.491 0.508 0.000
M05.34 Rheumatoid arthritis with involvement of other organs and systems (Hand)
0.491 0.508 0.000
M05.33 Rheumatoid arthritis with involvement of other organs and systems (Forearm)
0.491 0.508 0.000
M05.32 Rheumatoid arthritis with involvement of other organs and systems (Upper arm)
0.491 0.508 0.000
M05.31 Rheumatoid arthritis with involvement of other organs and systems (Shoulder region)
0.491 0.508 0.000
M05.30 Rheumatoid arthritis with involvement of other organs and systems (Multiple sites)
0.491 0.508 0.000
E06.5 Other chronic thyroiditis
0.000 0.509 0.490
E06.4 Drug-induced thyroiditis
0.000 0.509 0.490
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.509 0.490
E06.1 Subacute thyroiditis
0.000 0.509 0.490
E06.0 Acute thyroiditis
0.000 0.509 0.490
M08.9 Juvenile arthritis, unspecified
0.490 0.510 0.000
M08.8 Other juvenile arthritis
0.490 0.510 0.000
M08.4 Pauciarticular juvenile arthritis
0.490 0.510 0.000
M08.3 Juvenile polyarthritis (seronegative)
0.490 0.510 0.000
M08.2 Juvenile arthritis with systemic onset
0.490 0.510 0.000
M08.1 Juvenile ankylosing spondylitis
0.490 0.510 0.000
M08.0 Juvenile rheumatoid arthritis
0.490 0.510 0.000
M09.8 Juvenile arthritis in other diseases classified elsewhere
0.490 0.510 0.000
M09.2 Juvenile arthritis in ulcerative colitis
0.490 0.510 0.000
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]
0.490 0.510 0.000
M09.0 Juvenile arthritis in psoriasis
0.490 0.510 0.000
M11.9 Crystal arthropathy, unspecified
0.482 0.517 0.000
M11.8 Other specified crystal arthropathies
0.482 0.517 0.000
M11.1 Familial chondrocalcinosis
0.482 0.517 0.000
M11.0 Hydroxyapatite deposition disease
0.482 0.517 0.000
E61.2 Magnesium deficiency
0.000 0.519 0.481
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.521 0.479
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.525 0.475
E16 Other disorders of pancreatic internal secretion
0.000 0.526 0.474
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.526 0.474
E22.1 Hyperprolactinaemia
0.000 0.527 0.473
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.528 0.472
E22.8 Other hyperfunction of pituitary gland
0.000 0.528 0.472
M11.2 Other chondrocalcinosis
0.471 0.528 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.531 0.469
M07 Psoriatic and enteropathic arthropathies
0.456 0.532 0.012
E26.9 Hyperaldosteronism, unspecified
0.000 0.532 0.468
E26.8 Other hyperaldosteronism
0.000 0.532 0.468
E26.1 Secondary hyperaldosteronism
0.000 0.532 0.468
G37.5 Concentric sclerosis [Balo]
0.000 0.532 0.467
G37.4 Subacute necrotising myelitis
0.000 0.532 0.467
G37.2 Central pontine myelinolysis
0.000 0.532 0.467
G37.1 Central demyelination of corpus callosum
0.000 0.532 0.467
G37.0 Diffuse sclerosis
0.000 0.532 0.467
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.535 0.465
E21.2 Other hyperparathyroidism
0.000 0.535 0.464
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.464 0.536 0.000
L44 Other papulosquamous disorders
0.000 0.536 0.464
L41 Parapsoriasis
0.000 0.536 0.464
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.536 0.464
E29.9 Testicular dysfunction, unspecified
0.000 0.536 0.464
E29.8 Other testicular dysfunction
0.000 0.536 0.464
E29.0 Testicular hyperfunction
0.000 0.536 0.464
# Top node
0.000 0.537 0.463
E14 Unspecified diabetes mellitus
0.000 0.540 0.460
M06.48 Inflammatory polyarthropathy (Other)
0.460 0.540 0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.460 0.540 0.000
M06.46 Inflammatory polyarthropathy (Lower leg)
0.460 0.540 0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.460 0.540 0.000
M06.44 Inflammatory polyarthropathy (Hand)
0.460 0.540 0.000
M06.43 Inflammatory polyarthropathy (Forearm)
0.460 0.540 0.000
M06.42 Inflammatory polyarthropathy (Upper arm)
0.460 0.540 0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.460 0.540 0.000
D80-D89 Certain disorders involving the immune mechanism
0.000 0.541 0.459
Chapter VI Diseases of the nervous system
0.000 0.545 0.455
E21.3 Hyperparathyroidism, unspecified
0.000 0.545 0.454
Chapter I Certain infectious and parasitic diseases
0.000 0.548 0.452
D75 Other diseases of blood and blood-forming organs
0.000 0.550 0.450
E61.9 Deficiency of nutrient element, unspecified
0.000 0.554 0.446
E61.8 Deficiency of other specified nutrient elements
0.000 0.554 0.446
E61.7 Deficiency of multiple nutrient elements
0.000 0.554 0.446
E61.6 Vanadium deficiency
0.000 0.554 0.446
E61.5 Molybdenum deficiency
0.000 0.554 0.446
E61.4 Chromium deficiency
0.000 0.554 0.446
E61.3 Manganese deficiency
0.000 0.554 0.446
E61.0 Copper deficiency
0.000 0.554 0.446
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.554 0.446
L10-L14 Bullous disorders
0.000 0.559 0.441
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.559 0.441
D86 Sarcoidosis
0.000 0.562 0.438
E28.3 Primary ovarian failure
0.000 0.564 0.436
A50-A64 Infections with a predominantly sexual mode of transmission
0.000 0.565 0.435
E66.0 Obesity due to excess calories
0.000 0.570 0.430
E03 Other hypothyroidism
0.000 0.571 0.429
D69 Purpura and other haemorrhagic conditions
0.000 0.572 0.428
E24.9 Cushing's syndrome, unspecified
0.000 0.572 0.428
M14.8 Arthropathies in other specified diseases classified elsewhere
0.427 0.573 0.000
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders
0.427 0.573 0.000
M14.4 Arthropathy in amyloidosis
0.427 0.573 0.000
M14.3 Lipoid dermatoarthritis
0.427 0.573 0.000
M14.2 Diabetic arthropathy
0.427 0.573 0.000
M14.1 Crystal arthropathy in other metabolic disorders
0.427 0.573 0.000
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders
0.427 0.573 0.000
A63 Other predominantly sexually transmitted diseases, not elsewhere classified
0.000 0.576 0.424
D72 Other disorders of white blood cells
0.000 0.576 0.424
E06.3 Autoimmune thyroiditis
0.000 0.579 0.421
E28.9 Ovarian dysfunction, unspecified
0.000 0.581 0.419
E28.8 Other ovarian dysfunction
0.000 0.581 0.419
E28.1 Androgen excess
0.000 0.581 0.419
E28.0 Oestrogen excess
0.000 0.581 0.419
A63.0 Anogenital (venereal) warts
0.000 0.583 0.417
E66.8 Other obesity
0.000 0.585 0.415
D73 Diseases of spleen
0.000 0.585 0.415
M12.30 Palindromic rheumatism (Multiple sites)
0.414 0.585 0.000
E23.0 Hypopituitarism
0.000 0.586 0.414
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.586 0.414
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.588 0.411
E45 Retarded development following protein-energy malnutrition
0.000 0.588 0.411
E43 Unspecified severe protein-energy malnutrition
0.000 0.588 0.411
E42 Marasmic kwashiorkor
0.000 0.588 0.411
E41 Nutritional marasmus
0.000 0.588 0.411
E40 Kwashiorkor
0.000 0.588 0.411
E26.0 Primary hyperaldosteronism
0.000 0.589 0.411
D75.1 Secondary polycythaemia
0.000 0.590 0.410
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.591 0.409
C15.9 Oesophagus, unspecified
0.408 0.592 0.000
D55-D59 Haemolytic anaemias
0.000 0.592 0.408
E04 Other non-toxic goitre
0.000 0.593 0.407
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.595 0.405
E29.1 Testicular hypofunction
0.000 0.599 0.401
B25-B34 Other viral diseases
0.000 0.599 0.401
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.601 0.399
D72.8 Other specified disorders of white blood cells
0.000 0.601 0.399
D66 Hereditary factor VIII deficiency
0.000 0.605 0.395
G36.9 Acute disseminated demyelination, unspecified
0.000 0.605 0.395
G36.8 Other specified acute disseminated demyelination
0.000 0.605 0.395
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.605 0.395
G36.0 Neuromyelitis optica [Devic]
0.000 0.605 0.395
D86.0 Sarcoidosis of lung
0.000 0.606 0.394
E21.4 Other specified disorders of parathyroid gland
0.000 0.607 0.392
B15-B19 Viral hepatitis
0.000 0.608 0.392
M10.4 Other secondary gout
0.391 0.609 0.000
M10.3 Gout due to impairment of renal function
0.391 0.609 0.000
M10.2 Drug-induced gout
0.391 0.609 0.000
M10.1 Lead-induced gout
0.391 0.609 0.000
B35-B49 Mycoses
0.000 0.611 0.389
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.388 0.612 0.000
C15 Malignant neoplasm of oesophagus
0.387 0.613 0.000
E34.0 Carcinoid syndrome
0.000 0.614 0.386
M12.39 Palindromic rheumatism (Site unspecified)
0.385 0.615 0.000
M12.38 Palindromic rheumatism (Other)
0.385 0.615 0.000
M12.37 Palindromic rheumatism (Ankle and foot)
0.385 0.615 0.000
M12.36 Palindromic rheumatism (Lower leg)
0.385 0.615 0.000
M12.35 Palindromic rheumatism (Pelvic region and thigh)
0.385 0.615 0.000
M12.34 Palindromic rheumatism (Hand)
0.385 0.615 0.000
M12.33 Palindromic rheumatism (Forearm)
0.385 0.615 0.000
M12.32 Palindromic rheumatism (Upper arm)
0.385 0.615 0.000
M12.31 Palindromic rheumatism (Shoulder region)
0.385 0.615 0.000
E34.5 Androgen resistance syndrome
0.000 0.615 0.384
E34.4 Constitutional tall stature
0.000 0.615 0.384
E34.3 Short stature, not elsewhere classified
0.000 0.615 0.384
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.615 0.384
E34.1 Other hypersecretion of intestinal hormones
0.000 0.615 0.384

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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