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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs41265930
log Bayes Factor = 11.9369
Chromosome 6   position 160,964,135  (GRCh37) Explore rs41265930 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
Chapter IX Diseases of the circulatory system
0.000 0.000 1.000
I30-I52 Other forms of heart disease
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.001 0.999
I20 Angina pectoris
0.000 0.001 0.999
I51 Complications and ill-defined descriptions of heart disease
0.000 0.001 0.999
I51.8 Other ill-defined heart diseases
0.000 0.002 0.998
I60-I69 Cerebrovascular diseases
0.000 0.005 0.995
I20.9 Angina pectoris, unspecified
0.000 0.005 0.995
I25.2 Old myocardial infarction
0.000 0.006 0.994
I50 Heart failure
0.000 0.009 0.991
I21 Acute myocardial infarction
0.000 0.012 0.988
I20.0 Unstable angina
0.000 0.017 0.983
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.018 0.982
I35 Nonrheumatic aortic valve disorders
0.000 0.026 0.974
I67 Other cerebrovascular diseases
0.000 0.028 0.972
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.031 0.969
I50.1 Left ventricular failure
0.000 0.031 0.969
I77 Other disorders of arteries and arterioles
0.000 0.038 0.962
I67.9 Cerebrovascular disease, unspecified
0.000 0.051 0.949
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.079 0.921
I35.0 Aortic (valve) stenosis
0.000 0.079 0.921
I73 Other peripheral vascular diseases
0.000 0.084 0.916
I63 Cerebral infarction
0.000 0.086 0.914
I42 Cardiomyopathy
0.000 0.089 0.911
I51.9 Heart disease, unspecified
0.000 0.095 0.905
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.095 0.905
I63.9 Cerebral infarction, unspecified
0.000 0.096 0.904
I77.1 Stricture of artery
0.000 0.098 0.902
I21.4 Acute subendocardial myocardial infarction
0.000 0.099 0.900
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.105 0.895
I73.9 Peripheral vascular disease, unspecified
0.000 0.108 0.892
I67.8 Other specified cerebrovascular diseases
0.000 0.110 0.890
I34 Nonrheumatic mitral valve disorders
0.000 0.110 0.890
I50.9 Heart failure, unspecified
0.000 0.111 0.889
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.117 0.883
I77.8 Other specified disorders of arteries and arterioles
0.000 0.134 0.866
I34.1 Mitral (valve) prolapse
0.000 0.138 0.862
I42.0 Dilated cardiomyopathy
0.000 0.147 0.853
I25.3 Aneurysm of heart
0.000 0.154 0.846
I22 Subsequent myocardial infarction
0.000 0.164 0.836
I35.8 Other aortic valve disorders
0.000 0.164 0.836
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.000 0.194 0.806
I25.5 Ischaemic cardiomyopathy
0.000 0.204 0.796
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.207 0.793
I62 Other nontraumatic intracranial haemorrhage
0.000 0.209 0.791
I64 Stroke, not specified as haemorrhage or infarction
0.000 0.210 0.790
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.211 0.789
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.224 0.776
I74 Arterial embolism and thrombosis
0.000 0.227 0.773
I50.0 Congestive heart failure
0.000 0.234 0.766
I42.9 Cardiomyopathy, unspecified
0.000 0.251 0.749
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.255 0.744
I69 Sequelae of cerebrovascular disease
0.000 0.259 0.741
I33 Acute and subacute endocarditis
0.000 0.261 0.739
I51.6 Cardiovascular disease, unspecified
0.000 0.264 0.736
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.273 0.727
I21.9 Acute myocardial infarction, unspecified
0.000 0.277 0.723
I77.0 Arteriovenous fistula, acquired
0.000 0.278 0.722
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
I25.4 Coronary artery aneurysm
0.000 0.283 0.717
I23 Certain current complications following acute myocardial infarction
0.000 0.283 0.717
I00-I02 Acute rheumatic fever
0.000 0.283 0.717
I52 Other heart disorders in diseases classified elsewhere
0.000 0.283 0.717
I48 Atrial fibrillation and flutter
0.000 0.283 0.717
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.283 0.717
I41 Myocarditis in diseases classified elsewhere
0.000 0.283 0.717
I40 Acute myocarditis
0.000 0.283 0.717
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.283 0.717
I32 Pericarditis in diseases classified elsewhere
0.000 0.283 0.717
I61 Intracerebral haemorrhage
0.000 0.283 0.717
I51.5 Myocardial degeneration
0.000 0.284 0.716
I51.3 Intracardiac thrombosis, not elsewhere classified
0.000 0.284 0.716
I51.2 Rupture of papillary muscle, not elsewhere classified
0.000 0.284 0.716
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.000 0.284 0.716
I68 Cerebrovascular disorders in diseases classified elsewhere
0.000 0.286 0.713
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.000 0.286 0.713
I27 Other pulmonary heart diseases
0.000 0.287 0.713
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.291 0.709
I62.0 Subdural haemorrhage (acute) (nontraumatic)
0.000 0.293 0.707
I72 Other aneurysm
0.000 0.297 0.703
I67.2 Cerebral atherosclerosis
0.000 0.297 0.703
I67.7 Cerebral arteritis, not elsewhere classified
0.000 0.303 0.697
I67.6 Nonpyogenic thrombosis of intracranial venous system
0.000 0.303 0.697
I67.5 Moyamoya disease
0.000 0.303 0.697
I67.4 Hypertensive encephalopathy
0.000 0.303 0.697
I67.3 Progressive vascular leukoencephalopathy
0.000 0.303 0.697
I65.2 Occlusion and stenosis of carotid artery
0.000 0.305 0.695
I37 Pulmonary valve disorders
0.000 0.306 0.693
I77.5 Necrosis of artery
0.000 0.310 0.690
I77.4 Coeliac artery compression syndrome
0.000 0.310 0.690
I77.3 Arterial fibromuscular dysplasia
0.000 0.310 0.690
I77.2 Rupture of artery
0.000 0.310 0.690
I42.8 Other cardiomyopathies
0.000 0.312 0.688
I51.0 Cardiac septal defect, acquired
0.000 0.325 0.675
I24 Other acute ischaemic heart diseases
0.000 0.327 0.673
I36 Nonrheumatic tricuspid valve disorders
0.000 0.327 0.673
I05-I09 Chronic rheumatic heart diseases
0.000 0.327 0.672
I27.2 Other secondary pulmonary hypertension
0.000 0.329 0.671
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.343 0.657
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
0.000 0.344 0.656
I63.1 Cerebral infarction due to embolism of precerebral arteries
0.000 0.344 0.656
I63.0 Cerebral infarction due to thrombosis of precerebral arteries
0.000 0.344 0.656
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.346 0.654
I73.8 Other specified peripheral vascular diseases
0.000 0.347 0.653
I42.7 Cardiomyopathy due to drugs and other external agents
0.000 0.347 0.653
I42.6 Alcoholic cardiomyopathy
0.000 0.347 0.653
I42.5 Other restrictive cardiomyopathy
0.000 0.347 0.653
I42.4 Endocardial fibroelastosis
0.000 0.347 0.653
I42.3 Endomyocardial (eosinophilic) disease
0.000 0.347 0.653
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.348 0.651
I67.0 Dissection of cerebral arteries, nonruptured
0.000 0.350 0.650
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.352 0.648
I77.6 Arteritis, unspecified
0.000 0.361 0.639
I34.8 Other nonrheumatic mitral valve disorders
0.000 0.362 0.638
I34.2 Nonrheumatic mitral (valve) stenosis
0.000 0.362 0.638
I70 Atherosclerosis
0.000 0.373 0.627
I63.4 Cerebral infarction due to embolism of cerebral arteries
0.000 0.376 0.624
I31 Other diseases of pericardium
0.000 0.387 0.612
I72.4 Aneurysm of artery of lower extremity
0.000 0.388 0.612
H65-H75 Diseases of middle ear and mastoid
0.607 0.393 0.000
I69.1 Sequelae of intracerebral haemorrhage
0.000 0.399 0.601
M20.2 Hallux rigidus
0.000 0.401 0.599
I20.8 Other forms of angina pectoris
0.000 0.402 0.598
M20 Acquired deformities of fingers and toes
0.000 0.402 0.598
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.000 0.409 0.591
H66 Suppurative and unspecified otitis media
0.591 0.409 0.000
I42.1 Obstructive hypertrophic cardiomyopathy
0.000 0.409 0.591
M20.1 Hallux valgus (acquired)
0.000 0.409 0.591
I35.1 Aortic (valve) insufficiency
0.000 0.412 0.588
I63.8 Other cerebral infarction
0.000 0.414 0.585
I51.4 Myocarditis, unspecified
0.000 0.414 0.585
H71 Cholesteatoma of middle ear
0.584 0.416 0.000
I65.9 Occlusion and stenosis of unspecified precerebral artery
0.000 0.422 0.578
I65.8 Occlusion and stenosis of other precerebral artery
0.000 0.422 0.578
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries
0.000 0.422 0.578
I65.1 Occlusion and stenosis of basilar artery
0.000 0.422 0.578
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.425 0.575
I69.3 Sequelae of cerebral infarction
0.000 0.426 0.574
I30 Acute pericarditis
0.000 0.426 0.574
H66.9 Otitis media, unspecified
0.570 0.430 0.000
I62.1 Nontraumatic extradural haemorrhage
0.000 0.433 0.567
I28 Other diseases of pulmonary vessels
0.000 0.434 0.566
H65 Nonsuppurative otitis media
0.565 0.435 0.000
I74.8 Embolism and thrombosis of other arteries
0.000 0.435 0.564
H73 Other disorders of tympanic membrane
0.564 0.436 0.000
I74.5 Embolism and thrombosis of iliac artery
0.000 0.437 0.563
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.439 0.561
I22.8 Subsequent myocardial infarction of other sites
0.000 0.440 0.560
H74 Other disorders of middle ear and mastoid
0.560 0.440 0.000
I45 Other conduction disorders
0.000 0.445 0.555
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.446 0.554
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.446 0.554
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.446 0.554
I61.9 Intracerebral haemorrhage, unspecified
0.000 0.448 0.552
I33.0 Acute and subacute infective endocarditis
0.000 0.448 0.552
I60 Subarachnoid haemorrhage
0.000 0.455 0.545
I61.5 Intracerebral haemorrhage, intraventricular
0.000 0.462 0.537
I69.0 Sequelae of subarachnoid haemorrhage
0.000 0.465 0.534
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.466 0.534
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.466 0.534
I79.1 Aortitis in diseases classified elsewhere
0.000 0.466 0.534
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.466 0.534
H73.8 Other specified disorders of tympanic membrane
0.533 0.467 0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage
0.000 0.469 0.531
I33.9 Acute endocarditis, unspecified
0.000 0.470 0.530
I38 Endocarditis, valve unspecified
0.000 0.470 0.530
I65.0 Occlusion and stenosis of vertebral artery
0.000 0.472 0.528
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.473 0.527
I51.7 Cardiomegaly
0.000 0.474 0.526
I07 Rheumatic tricuspid valve diseases
0.000 0.477 0.523
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.000 0.478 0.522
M20.5 Other deformities of toe(s) (acquired)
0.000 0.479 0.521
H72 Perforation of tympanic membrane
0.520 0.480 0.000
I61.1 Intracerebral haemorrhage in hemisphere, cortical
0.000 0.480 0.520
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.481 0.519
H65.2 Chronic serous otitis media
0.516 0.484 0.000
I63.3 Cerebral infarction due to thrombosis of cerebral arteries
0.000 0.486 0.514
I23.8 Other current complications following acute myocardial infarction
0.000 0.486 0.514
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.486 0.514
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.486 0.514
I02 Rheumatic chorea
0.000 0.486 0.514
I01 Rheumatic fever with heart involvement
0.000 0.486 0.514
I00 Rheumatic fever without mention of heart involvement
0.000 0.486 0.514
I32.8 Pericarditis in other diseases classified elsewhere
0.000 0.486 0.514
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.486 0.514
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.000 0.486 0.514
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.000 0.486 0.514
I39.4 Multiple valve disorders in diseases classified elsewhere
0.000 0.486 0.514
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.000 0.486 0.514
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.000 0.486 0.514
I39.1 Aortic valve disorders in diseases classified elsewhere
0.000 0.486 0.514
I39.0 Mitral valve disorders in diseases classified elsewhere
0.000 0.486 0.514
I40.9 Acute myocarditis, unspecified
0.000 0.486 0.514
I40.8 Other acute myocarditis
0.000 0.486 0.514
I40.1 Isolated myocarditis
0.000 0.486 0.514
I40.0 Infective myocarditis
0.000 0.486 0.514
I41.8 Myocarditis in other diseases classified elsewhere
0.000 0.486 0.514
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.486 0.514
I41.1 Myocarditis in viral diseases classified elsewhere
0.000 0.486 0.514
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.000 0.486 0.514
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.000 0.486 0.514
I43.2 Cardiomyopathy in nutritional diseases
0.000 0.486 0.514
I43.1 Cardiomyopathy in metabolic diseases
0.000 0.486 0.514
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.000 0.486 0.514
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.000 0.486 0.514
I48.4 Atypical atrial flutter
0.000 0.486 0.514
I48.3 Typical atrial flutter
0.000 0.486 0.514
I48.2 Chronic atrial fibrillation
0.000 0.486 0.514
I48.1 Persistent atrial fibrillation
0.000 0.486 0.514
I48.0 Paroxysmal atrial fibrillation
0.000 0.486 0.514
I52.8 Other heart disorders in other diseases classified elsewhere
0.000 0.486 0.514
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.486 0.514
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.000 0.486 0.514
I61.6 Intracerebral haemorrhage, multiple localised
0.000 0.486 0.514
I61.4 Intracerebral haemorrhage in cerebellum
0.000 0.486 0.514
I61.3 Intracerebral haemorrhage in brain stem
0.000 0.486 0.514
I61.2 Intracerebral haemorrhage in hemisphere, unspecified
0.000 0.486 0.514
I61.0 Intracerebral haemorrhage in hemisphere, subcortical
0.000 0.486 0.514
I66.9 Occlusion and stenosis of unspecified cerebral artery
0.000 0.488 0.512
I66.8 Occlusion and stenosis of other cerebral artery
0.000 0.488 0.512
I66.4 Occlusion and stenosis of multiple and bilateral cerebral arteries
0.000 0.488 0.512
I66.3 Occlusion and stenosis of cerebellar arteries
0.000 0.488 0.512
I66.2 Occlusion and stenosis of posterior cerebral artery
0.000 0.488 0.512
I66.1 Occlusion and stenosis of anterior cerebral artery
0.000 0.488 0.512
I66.0 Occlusion and stenosis of middle cerebral artery
0.000 0.488 0.512
I68.8 Other cerebrovascular disorders in diseases classified elsewhere
0.000 0.488 0.512
I68.2 Cerebral arteritis in other diseases classified elsewhere
0.000 0.488 0.512
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere
0.000 0.488 0.512
I68.0 Cerebral amyloid angiopathy
0.000 0.488 0.512
I27.8 Other specified pulmonary heart diseases
0.000 0.489 0.511
I27.1 Kyphoscoliotic heart disease
0.000 0.489 0.511
M20.4 Other hammer toe(s) (acquired)
0.000 0.492 0.508
I27.0 Primary pulmonary hypertension
0.000 0.492 0.508
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.496 0.504
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.496 0.504
I72.2 Aneurysm of renal artery
0.000 0.496 0.504
I72.1 Aneurysm of artery of upper extremity
0.000 0.496 0.504
I37.9 Pulmonary valve disorder, unspecified
0.000 0.503 0.497
I37.8 Other pulmonary valve disorders
0.000 0.503 0.497
I37.2 Pulmonary valve stenosis with insufficiency
0.000 0.503 0.497
I37.0 Pulmonary valve stenosis
0.000 0.503 0.497
I35.9 Aortic valve disorder, unspecified
0.000 0.504 0.496
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.504 0.496
I42.2 Other hypertrophic cardiomyopathy
0.000 0.512 0.487
I72.3 Aneurysm of iliac artery
0.000 0.513 0.487
I24.1 Dressler's syndrome
0.000 0.517 0.483
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.000 0.517 0.483
I36.8 Other nonrheumatic tricuspid valve disorders
0.000 0.517 0.483
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.000 0.517 0.483
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.000 0.517 0.483
I06 Rheumatic aortic valve diseases
0.000 0.518 0.482
M20.6 Acquired deformity of toe(s), unspecified
0.000 0.518 0.482
I71 Aortic aneurysm and dissection
0.000 0.521 0.478
M20.0 Deformity of finger(s)
0.000 0.523 0.477
I34.0 Mitral (valve) insufficiency
0.000 0.523 0.477
I37.1 Pulmonary valve insufficiency
0.000 0.526 0.474
H66.3 Other chronic suppurative otitis media
0.469 0.531 0.000
I45.1 Other and unspecified right bundle-branch block
0.000 0.531 0.469
I72.9 Aneurysm of unspecified site
0.000 0.534 0.466
H66.4 Suppurative otitis media, unspecified
0.464 0.536 0.000
H74.3 Other acquired abnormalities of ear ossicles
0.463 0.537 0.000
I08 Multiple valve diseases
0.000 0.539 0.461
H74.2 Discontinuity and dislocation of ear ossicles
0.461 0.539 0.000
H65.4 Other chronic nonsuppurative otitis media
0.459 0.541 0.000
I72.0 Aneurysm of carotid artery
0.000 0.541 0.459
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.001 0.544 0.456
I09 Other rheumatic heart diseases
0.000 0.545 0.455
M20.3 Other deformity of hallux (acquired)
0.000 0.545 0.455
I31.9 Disease of pericardium, unspecified
0.000 0.549 0.451
I27.9 Pulmonary heart disease, unspecified
0.000 0.550 0.450
I70.9 Generalised and unspecified atherosclerosis
0.000 0.550 0.449
I70.8 Atherosclerosis of other arteries
0.000 0.550 0.449
I24.8 Other forms of acute ischaemic heart disease
0.000 0.551 0.449
I20.1 Angina pectoris with documented spasm
0.001 0.553 0.447
H72.9 Perforation of tympanic membrane, unspecified
0.445 0.555 0.000
H74.8 Other specified disorders of middle ear and mastoid
0.445 0.555 0.000
I70.0 Atherosclerosis of aorta
0.000 0.556 0.444
I78 Diseases of capillaries
0.000 0.557 0.443
I45.9 Conduction disorder, unspecified
0.000 0.557 0.443
I31.8 Other specified diseases of pericardium
0.000 0.561 0.439
I31.2 Haemopericardium, not elsewhere classified
0.000 0.561 0.439
I31.1 Chronic constrictive pericarditis
0.000 0.561 0.439
I31.0 Chronic adhesive pericarditis
0.000 0.561 0.439
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.000 0.561 0.439
I05 Rheumatic mitral valve diseases
0.000 0.562 0.438
I08.0 Disorders of both mitral and aortic valves
0.000 0.562 0.438
I46 Cardiac arrest
0.000 0.564 0.436
H74.9 Disorder of middle ear and mastoid, unspecified
0.435 0.565 0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.435 0.565 0.000
H68 Eustachian salpingitis and obstruction
0.435 0.565 0.000
H67 Otitis media in diseases classified elsewhere
0.435 0.565 0.000
H65.9 Nonsuppurative otitis media, unspecified
0.432 0.568 0.000
I61.8 Other intracerebral haemorrhage
0.000 0.571 0.429
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
0.000 0.573 0.427
I72.8 Aneurysm of other specified arteries
0.000 0.573 0.427
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.574 0.426
H66.2 Chronic atticoantral suppurative otitis media
0.424 0.576 0.000
H66.1 Chronic tubotympanic suppurative otitis media
0.424 0.576 0.000
H66.0 Acute suppurative otitis media
0.424 0.576 0.000
H72.2 Other marginal perforations of tympanic membrane
0.420 0.580 0.000
I73.0 Raynaud's syndrome
0.000 0.582 0.418
I07.1 Tricuspid insufficiency
0.000 0.584 0.416
I30.8 Other forms of acute pericarditis
0.000 0.588 0.412
I30.1 Infective pericarditis
0.000 0.588 0.412
I30.0 Acute nonspecific idiopathic pericarditis
0.000 0.588 0.412
I70.1 Atherosclerosis of renal artery
0.000 0.591 0.409
H74.0 Tympanosclerosis
0.407 0.593 0.000
I28.9 Disease of pulmonary vessels, unspecified
0.000 0.594 0.406
I28.8 Other specified diseases of pulmonary vessels
0.000 0.594 0.406
I28.1 Aneurysm of pulmonary artery
0.000 0.594 0.406
I28.0 Arteriovenous fistula of pulmonary vessels
0.000 0.594 0.406
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.000 0.595 0.405
H65.1 Other acute nonsuppurative otitis media
0.405 0.595 0.000
H65.0 Acute serous otitis media
0.405 0.595 0.000
H70 Mastoiditis and related conditions
0.405 0.595 0.000
H73.9 Disorder of tympanic membrane, unspecified
0.404 0.596 0.000
H73.1 Chronic myringitis
0.404 0.596 0.000
H73.0 Acute myringitis
0.404 0.596 0.000
I60.9 Subarachnoid haemorrhage, unspecified
0.000 0.597 0.403
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.598 0.402
H74.1 Adhesive middle ear disease
0.401 0.598 0.000
I60.2 Subarachnoid haemorrhage from anterior communicating artery
0.000 0.601 0.399
H74.4 Polyp of middle ear
0.399 0.601 0.000
I62.9 Intracranial haemorrhage (nontraumatic), unspecified
0.001 0.601 0.398
I45.8 Other specified conduction disorders
0.000 0.602 0.398
I45.0 Right fascicular block
0.000 0.602 0.398
I60.8 Other subarachnoid haemorrhage
0.000 0.608 0.392
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified
0.000 0.609 0.391
I60.6 Subarachnoid haemorrhage from other intracranial arteries
0.000 0.609 0.391
I60.5 Subarachnoid haemorrhage from vertebral artery
0.000 0.609 0.391
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation
0.000 0.609 0.391
H69 Other disorders of Eustachian tube
0.390 0.610 0.000
I67.1 Cerebral aneurysm, nonruptured
0.000 0.615 0.384
H65.3 Chronic mucoid otitis media
0.383 0.617 0.000
I60.3 Subarachnoid haemorrhage from posterior communicating artery
0.000 0.619 0.381
I45.4 Nonspecific intraventricular block
0.000 0.620 0.380
I45.5 Other specified heart block
0.000 0.623 0.377
I07.9 Tricuspid valve disease, unspecified
0.000 0.625 0.375
I07.8 Other tricuspid valve diseases
0.000 0.625 0.375
I07.2 Tricuspid stenosis with insufficiency
0.000 0.625 0.375
I07.0 Tricuspid stenosis
0.000 0.625 0.375
H72.8 Other perforations of tympanic membrane
0.375 0.625 0.000
I08.8 Other multiple valve diseases
0.000 0.625 0.374
H72.1 Attic perforation of tympanic membrane
0.373 0.627 0.000
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.631 0.369
I01.8 Other acute rheumatic heart disease
0.000 0.631 0.369
I01.2 Acute rheumatic myocarditis
0.000 0.631 0.369
I01.1 Acute rheumatic endocarditis
0.000 0.631 0.369
I01.0 Acute rheumatic pericarditis
0.000 0.631 0.369
I02.9 Rheumatic chorea without heart involvement
0.000 0.631 0.369
I02.0 Rheumatic chorea with heart involvement
0.000 0.631 0.369
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.000 0.632 0.368
I49 Other cardiac arrhythmias
0.000 0.638 0.361
I60.4 Subarachnoid haemorrhage from basilar artery
0.000 0.646 0.353
I26 Pulmonary embolism
0.000 0.651 0.349
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.654 0.346
I06.8 Other rheumatic aortic valve diseases
0.000 0.654 0.346
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.654 0.346
I06.1 Rheumatic aortic insufficiency
0.000 0.654 0.346
I06.0 Rheumatic aortic stenosis
0.000 0.654 0.346
I71.8 Aortic aneurysm of unspecified site, ruptured
0.000 0.657 0.343
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.000 0.657 0.343
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.000 0.657 0.343
I71.1 Thoracic aortic aneurysm, ruptured
0.000 0.657 0.343
H72.0 Central perforation of tympanic membrane
0.339 0.661 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.000 0.665 0.335
I08.9 Multiple valve disease, unspecified
0.000 0.669 0.330
I45.6 Preexcitation syndrome
0.000 0.670 0.330
I09.8 Other specified rheumatic heart diseases
0.000 0.674 0.326
I09.2 Chronic rheumatic pericarditis
0.000 0.674 0.326
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.000 0.674 0.326
I09.0 Rheumatic myocarditis
0.000 0.674 0.326
I70.81 Atherosclerosis of other arteries (with gangrene)
0.000 0.678 0.322
I70.80 Atherosclerosis of other arteries (without gangrene)
0.000 0.678 0.322
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.000 0.678 0.322
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.000 0.678 0.322
I05.1 Rheumatic mitral insufficiency
0.000 0.678 0.321
I05.9 Mitral valve disease, unspecified
0.000 0.679 0.320
I70.01 Atherosclerosis of aorta (with gangrene)
0.000 0.682 0.318
I78.9 Disease of capillaries, unspecified
0.000 0.682 0.317
I10-I15 Hypertensive diseases
0.000 0.683 0.317
I05.8 Other mitral valve diseases
0.000 0.686 0.314
I31.3 Pericardial effusion (noninflammatory)
0.000 0.686 0.314
I46.1 Sudden cardiac death, so described
0.000 0.687 0.313
I70.00 Atherosclerosis of aorta (without gangrene)
0.000 0.688 0.312
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.688 0.312
H67.8 Otitis media in other diseases classified elsewhere
0.312 0.688 0.000
H67.1 Otitis media in viral diseases classified elsewhere
0.312 0.688 0.000
H67.0 Otitis media in bacterial diseases classified elsewhere
0.312 0.688 0.000
H68.1 Obstruction of Eustachian tube
0.312 0.688 0.000
H68.0 Eustachian salpingitis
0.312 0.688 0.000
H75.8 Other specified disorders of middle ear and mastoid in diseases classified elsewhere
0.312 0.688 0.000
H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere
0.312 0.688 0.000
I45.2 Bifascicular block
0.000 0.693 0.307
I47 Paroxysmal tachycardia
0.000 0.694 0.306
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.696 0.304
I05.2 Mitral stenosis with insufficiency
0.000 0.697 0.303
I49.9 Cardiac arrhythmia, unspecified
0.000 0.700 0.300
I09.9 Rheumatic heart disease, unspecified
0.000 0.701 0.299
I78.8 Other diseases of capillaries
0.000 0.705 0.294
I70.11 Atherosclerosis of renal artery (with gangrene)
0.000 0.707 0.293
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.708 0.291
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.709 0.291
H70.8 Other mastoiditis and related conditions
0.290 0.710 0.000
H70.2 Petrositis
0.290 0.710 0.000
H70.1 Chronic mastoiditis
0.290 0.710 0.000
H70.0 Acute mastoiditis
0.290 0.710 0.000
Chapter VIII Diseases of the ear and mastoid process
0.289 0.711 0.000
I44 Atrioventricular and left bundle-branch block
0.000 0.715 0.285
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.715 0.285
I71.0 Dissection of aorta [any part]
0.000 0.720 0.280
H69.0 Patulous Eustachian tube
0.280 0.720 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.000 0.725 0.275
I49.8 Other specified cardiac arrhythmias
0.000 0.730 0.270
I30.9 Acute pericarditis, unspecified
0.001 0.731 0.269
I45.3 Trifascicular block
0.001 0.731 0.269
I05.0 Mitral stenosis
0.000 0.733 0.266
I60.1 Subarachnoid haemorrhage from middle cerebral artery
0.001 0.738 0.261
H69.9 Eustachian tube disorder, unspecified
0.261 0.738 0.000
H70.9 Mastoiditis, unspecified
0.260 0.740 0.000
I49.2 Junctional premature depolarisation
0.000 0.741 0.259
H69.8 Other specified disorders of Eustachian tube
0.256 0.743 0.000
I70.10 Atherosclerosis of renal artery (without gangrene)
0.000 0.747 0.252
H90-H95 Other disorders of ear
0.252 0.748 0.000
I49.3 Ventricular premature depolarisation
0.000 0.750 0.250
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.752 0.248
I15 Secondary hypertension
0.000 0.756 0.244
H90 Conductive and sensorineural hearing loss
0.239 0.761 0.000
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.000 0.768 0.232
I46.9 Cardiac arrest, unspecified
0.000 0.769 0.231
I44.1 Atrioventricular block, second degree
0.000 0.771 0.229
I13 Hypertensive heart and renal disease
0.000 0.772 0.228
I49.1 Atrial premature depolarisation
0.000 0.775 0.225
I47.0 Reentry ventricular arrhythmia
0.000 0.777 0.223
I11 Hypertensive heart disease
0.000 0.777 0.223
I44.3 Other and unspecified atrioventricular block
0.000 0.783 0.216
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
0.215 0.785 0.000
I44.5 Left posterior fascicular block
0.000 0.795 0.204
I44.4 Left anterior fascicular block
0.000 0.795 0.204
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.801 0.199
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.802 0.197
I08.2 Disorders of both aortic and tricuspid valves
0.001 0.804 0.195
H90.5 Sensorineural hearing loss, unspecified
0.195 0.805 0.000
H90.7 Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
0.195 0.805 0.000
I46.0 Cardiac arrest with successful resuscitation
0.000 0.807 0.193
H90.8 Mixed conductive and sensorineural hearing loss, unspecified
0.192 0.808 0.000
H60-H62 Diseases of external ear
0.191 0.809 0.000
I15.1 Hypertension secondary to other renal disorders
0.000 0.809 0.191
Z86.7 Personal history of diseases of the circulatory system
0.000 0.809 0.191
I49.4 Other and unspecified premature depolarisation
0.000 0.811 0.189
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified
0.185 0.814 0.000
I99 Other and unspecified disorders of circulatory system
0.000 0.818 0.181
H94 Other disorders of ear in diseases classified elsewhere
0.181 0.819 0.000
H90.4 Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
0.177 0.823 0.000
I15.9 Seconday hypertension, unspecified
0.000 0.825 0.175
I15.8 Other secondary hypertension
0.000 0.825 0.175
I15.2 Hypertension secondary to endocrine disorders
0.000 0.825 0.175
I15.0 Renovascular hypertension
0.000 0.825 0.175
I47.2 Ventricular tachycardia
0.000 0.825 0.175
I49.5 Sick sinus syndrome
0.000 0.826 0.174
I44.6 Other and unspecified fascicular block
0.000 0.826 0.174
I49.0 Ventricular fibrillation and flutter
0.000 0.826 0.174
I44.0 Atrioventricular block, first degree
0.000 0.827 0.173
I78.1 Naevus, nonneoplastic
0.000 0.827 0.173
H93 Other disorders of ear, not elsewhere classified
0.173 0.827 0.000
H90.2 Conductive hearing loss, unspecified
0.172 0.828 0.000
H90.6 Mixed conductive and sensorineural hearing loss, bilateral
0.171 0.829 0.000
H80-H83 Diseases of inner ear
0.171 0.829 0.000
H92 Otalgia and effusion of ear
0.167 0.833 0.000
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.836 0.163
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.836 0.163
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.836 0.163
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.836 0.163
H90.0 Conductive hearing loss, bilateral
0.160 0.840 0.000
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.840 0.160
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.845 0.155
I97.1 Other functional disturbances following cardiac surgery
0.000 0.847 0.152
H61 Other disorders of external ear
0.152 0.848 0.000
I12 Hypertensive renal disease
0.000 0.848 0.152
H91 Other hearing loss
0.147 0.853 0.000
H95.0 Recurrent cholesteatoma of postmastoidectomy cavity
0.143 0.857 0.000
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.000 0.857 0.143
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.000 0.857 0.143
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.857 0.143
I98.0 Cardiovascular syphilis
0.000 0.857 0.143
H90.3 Sensorineural hearing loss, bilateral
0.143 0.857 0.000
I97.9 Postprocedural disorder of circulatory system, unspecified
0.000 0.858 0.141
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.858 0.141
I97.0 Postcardiotomy syndrome
0.000 0.858 0.141
H93.8 Other specified disorders of ear
0.138 0.862 0.000
H62 Disorders of external ear in diseases classified elsewhere
0.137 0.863 0.000
I47.1 Supraventricular tachycardia
0.000 0.864 0.136
I47.9 Paroxysmal tachycardia, unspecified
0.001 0.867 0.133

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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