TreeWAS – Variant ID: rs41288889

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	No effect posterior probability	Protective posterior probability
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.000	1.000
E03.9 Hypothyroidism, unspecified	0.000	1.000
E10.9 Without complications	0.000	1.000
E10 Insulin-dependent diabetes mellitus	0.000	1.000
K90.0 Coeliac disease	0.000	1.000
M06.9 Rheumatoid arthritis, unspecified	0.000	1.000
E10-E14 Diabetes mellitus	0.000	1.000
E03 Other hypothyroidism	0.001	0.999
E00-E07 Disorders of thyroid gland	0.001	0.999
Chapter IV Endocrine, nutritional and metabolic diseases	0.001	0.999
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.002	0.998
J45.9 Asthma, unspecified	0.005	0.995
E10.3 With ophthalmic complications	0.020	0.980
E11 Non-insulin-dependent diabetes mellitus	0.025	0.975
E65-E68 Obesity and other hyperalimentation	0.075	0.925
E11.3 With ophthalmic complications	0.085	0.915
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.088	0.912
E10.4 With neurological complications	0.103	0.897
E10.1 With ketoacidosis	0.107	0.893
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.125	0.875
E66 Obesity	0.132	0.868
E07 Other disorders of thyroid	0.136	0.864
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.165	0.835
E10.5 With peripheral circulatory complications	0.167	0.833
E11.5 With peripheral circulatory complications	0.170	0.830
M06 Other rheumatoid arthritis	0.177	0.823
E66.8 Other obesity	0.192	0.808
E11.9 Without complications	0.209	0.791
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.216	0.784
E40-E46 Malnutrition	0.227	0.773
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.228	0.772
E07.9 Disorder of thyroid, unspecified	0.230	0.770
E14 Unspecified diabetes mellitus	0.239	0.761
E05 Thyrotoxicosis [hyperthyroidism]	0.247	0.753
E11.1 With ketoacidosis	0.248	0.752
E50-E64 Other nutritional deficiencies	0.248	0.752
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.248	0.751
E11.0 With coma	0.258	0.742
E11.4 With neurological complications	0.279	0.721
E10.8 With unspecified complications	0.283	0.717
E10.7 With multiple complications	0.283	0.717
E10.6 With other specified complications	0.283	0.717
E10.2 With renal complications	0.283	0.717
E10.0 With coma	0.283	0.717
M06.98 Rheumatoid arthritis, unspecified (Other)	0.283	0.717
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.283	0.717
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.283	0.717
E12 Malnutrition-related diabetes mellitus	0.283	0.717
E03.5 Myxoedema coma	0.284	0.716
E03.4 Atrophy of thyroid (acquired)	0.284	0.716
E03.3 Postinfectious hypothyroidism	0.284	0.716
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.284	0.716
E03.1 Congenital hypothyroidism without goitre	0.284	0.716
E03.0 Congenital hypothyroidism with diffuse goitre	0.284	0.716
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.284	0.716
E00 Congenital iodine-deficiency syndrome	0.284	0.716
E02 Subclinical iodine-deficiency hypothyroidism	0.284	0.716
E13 Other specified diabetes mellitus	0.285	0.715
E06 Thyroiditis	0.285	0.715
M06.0 Seronegative rheumatoid arthritis	0.288	0.712
E66.9 Obesity, unspecified	0.299	0.701
E11.7 With multiple complications	0.301	0.699
E11.8 With unspecified complications	0.302	0.698
E65 Localised adiposity	0.318	0.682
E14.3 With ophthalmic complications	0.331	0.669
E67 Other hyperalimentation	0.337	0.663
E68 Sequelae of hyperalimentation	0.337	0.663
E11.6 With other specified complications	0.342	0.658
E03.8 Other specified hypothyroidism	0.343	0.657
E11.2 With renal complications	0.349	0.651
E66.2 Extreme obesity with alveolar hypoventilation	0.378	0.622
E66.1 Drug-induced obesity	0.378	0.622
E66.0 Obesity due to excess calories	0.378	0.622
E07.1 Dyshormogenetic goitre	0.380	0.619
E07.0 Hypersecretion of calcitonin	0.380	0.619
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.381	0.619
E07.8 Other specified disorders of thyroid	0.387	0.613
E46 Unspecified protein-energy malnutrition	0.389	0.611
E53 Deficiency of other B group vitamins	0.392	0.608
M06.8 Other specified rheumatoid arthritis	0.410	0.590
M06.3 Rheumatoid nodule	0.410	0.590
M06.2 Rheumatoid bursitis	0.410	0.590
M06.1 Adult-onset Still's disease	0.410	0.590
M05-M14 Inflammatory polyarthropathies	0.414	0.586
E05.9 Thyrotoxicosis, unspecified	0.415	0.585
E16 Other disorders of pancreatic internal secretion	0.426	0.574
M06.4 Inflammatory polyarthropathy	0.439	0.561
M05 Seropositive rheumatoid arthritis	0.444	0.556
E44 Protein-energy malnutrition of moderate and mild degree	0.446	0.554
E45 Retarded development following protein-energy malnutrition	0.446	0.554
E43 Unspecified severe protein-energy malnutrition	0.446	0.554
E42 Marasmic kwashiorkor	0.446	0.554
E41 Nutritional marasmus	0.446	0.554
E40 Kwashiorkor	0.446	0.554
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.449	0.551
E06.3 Autoimmune thyroiditis	0.454	0.546
E14.8 With unspecified complications	0.454	0.546
E14.7 With multiple complications	0.454	0.546
E14.6 With other specified complications	0.454	0.546
E14.5 With peripheral circulatory complications	0.454	0.546
E14.4 With neurological complications	0.454	0.546
E14.2 Withrenal complications	0.454	0.546
E14.1 With ketoacidosis	0.454	0.546
E14.0 With coma	0.454	0.546
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.458	0.542
E05.8 Other thyrotoxicosis	0.460	0.540
E05.5 Thyroid crisis or storm	0.460	0.540
E05.4 Thyrotoxicosis factitia	0.460	0.540
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.460	0.540
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.460	0.540
E64 Sequelae of malnutrition and other nutritional deficiencies	0.461	0.539
E63 Other nutritional deficiencies	0.461	0.539
E56 Other vitamin deficiencies	0.461	0.539
E51 Thiamine deficiency	0.461	0.539
E50 Vitamin A deficiency	0.461	0.539
E60 Dietary zinc deficiency	0.461	0.539
E59 Dietary selenium deficiency	0.461	0.539
E58 Dietary calcium deficiency	0.461	0.539
E54 Ascorbic acid deficiency	0.461	0.539
E52 Niacin deficiency [pellagra]	0.461	0.539
E15 Nondiabetic hypoglycaemic coma	0.461	0.539
M05.9 Seropositive rheumatoid arthritis, unspecified	0.465	0.535
E61 Deficiency of other nutrient elements	0.476	0.523
E05.0 Thyrotoxicosis with diffuse goitre	0.481	0.519
E12.9 Without complications	0.486	0.514
E12.8 With unspecified complications	0.486	0.514
E12.7 With multiple complications	0.486	0.514
E12.6 With other specified complications	0.486	0.514
E12.5 With peripheral circulatory complications	0.486	0.514
E12.4 With neurological complications	0.486	0.514
E12.3 With ophthalmic complications	0.486	0.514
E12.2 With renal complications	0.486	0.514
E12.1 With ketoacidosis	0.486	0.514
E12.0 With coma	0.486	0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.487	0.513
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.487	0.513
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.487	0.513
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.487	0.513
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.487	0.513
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.487	0.513
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.487	0.513
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.487	0.513
E13.8 With unspecified complications	0.487	0.513
E13.7 With multiple complications	0.487	0.513
E13.6 With other specified complications	0.487	0.513
E13.5 With peripheral circulatory complications	0.487	0.513
E13.4 With neurological complications	0.487	0.513
E13.3 With ophthalmic complications	0.487	0.513
E13.2 With renal complications	0.487	0.513
E13.1 With ketoacidosis	0.487	0.513
E13.0 With coma	0.487	0.513
E06.5 Other chronic thyroiditis	0.487	0.513
E06.4 Drug-induced thyroiditis	0.487	0.513
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.487	0.513
E06.1 Subacute thyroiditis	0.487	0.513
E06.0 Acute thyroiditis	0.487	0.513
E13.9 Without complications	0.489	0.511
M06.08 Seronegative rheumatoid arthritis (Other)	0.489	0.511
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)	0.489	0.511
M06.06 Seronegative rheumatoid arthritis (Lower leg)	0.489	0.511
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)	0.489	0.511
M06.04 Seronegative rheumatoid arthritis (Hand)	0.489	0.511
M06.03 Seronegative rheumatoid arthritis (Forearm)	0.489	0.511
M06.02 Seronegative rheumatoid arthritis (Upper arm)	0.489	0.511
M06.01 Seronegative rheumatoid arthritis (Shoulder region)	0.489	0.511
E55 Vitamin D deficiency	0.492	0.508
E53.8 Deficiency of other specified B group vitamins	0.496	0.504
J45 Asthma	0.497	0.503
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.503	0.497
E67.8 Other specified hyperalimentation	0.524	0.475
E67.3 Hypervitaminosis D	0.524	0.475
E67.2 Megavitamin-B6 syndrome	0.524	0.475
E67.1 Hypercarotenaemia	0.524	0.475
E67.0 Hypervitaminosis A	0.524	0.475
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.528	0.472
E06.9 Thyroiditis, unspecified	0.528	0.471
E70-E90 Metabolic disorders	0.541	0.459
E16.2 Hypoglycaemia, unspecified	0.553	0.447
M13 Other arthritis	0.555	0.445
E53.9 Vitamin B deficiency, unspecified	0.564	0.436
E53.1 Pyridoxine deficiency	0.564	0.436
E53.0 Riboflavin deficiency	0.564	0.436
K90 Intestinal malabsorption	0.569	0.431
M06.19 Adult-onset Still's disease (Site unspecified)	0.577	0.423
M06.18 Adult-onset Still's disease (Other)	0.577	0.423
M06.17 Adult-onset Still's disease (Ankle and foot)	0.577	0.423
M06.16 Adult-onset Still's disease (Lower leg)	0.577	0.423
M06.15 Adult-onset Still's disease (Pelvic region and thigh)	0.577	0.423
M06.14 Adult-onset Still's disease (Hand)	0.577	0.423
M06.13 Adult-onset Still's disease (Forearm)	0.577	0.423
M06.12 Adult-onset Still's disease (Upper arm)	0.577	0.423
M06.11 Adult-onset Still's disease (Shoulder region)	0.577	0.423
M06.10 Adult-onset Still's disease (Multiple sites)	0.577	0.423
M06.29 Rheumatoid bursitis (Site unspecified)	0.577	0.423
M06.28 Rheumatoid bursitis (Other)	0.577	0.423
M06.27 Rheumatoid bursitis (Ankle and foot)	0.577	0.423
M06.26 Rheumatoid bursitis (Lower leg)	0.577	0.423
M06.25 Rheumatoid bursitis (Pelvic region and thigh)	0.577	0.423
M06.24 Rheumatoid bursitis (Hand)	0.577	0.423
M06.23 Rheumatoid bursitis (Forearm)	0.577	0.423
M06.22 Rheumatoid bursitis (Upper arm)	0.577	0.423
M06.21 Rheumatoid bursitis (Shoulder region)	0.577	0.423
M06.20 Rheumatoid bursitis (Multiple sites)	0.577	0.423
M06.39 Rheumatoid nodule (Site unspecified)	0.577	0.423
M06.38 Rheumatoid nodule (Other)	0.577	0.423
M06.37 Rheumatoid nodule (Ankle and foot)	0.577	0.423
M06.36 Rheumatoid nodule (Lower leg)	0.577	0.423
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.577	0.423
M06.34 Rheumatoid nodule (Hand)	0.577	0.423
M06.33 Rheumatoid nodule (Forearm)	0.577	0.423
M06.32 Rheumatoid nodule (Upper arm)	0.577	0.423
M06.31 Rheumatoid nodule (Shoulder region)	0.577	0.423
M06.30 Rheumatoid nodule (Multiple sites)	0.577	0.423
M06.89 Other specified rheumatoid arthritis (Site unspecified)	0.577	0.423
M06.88 Other specified rheumatoid arthritis (Other)	0.577	0.423
M06.87 Other specified rheumatoid arthritis (Ankle and foot)	0.577	0.423
M06.86 Other specified rheumatoid arthritis (Lower leg)	0.577	0.423
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)	0.577	0.423
M06.84 Other specified rheumatoid arthritis (Hand)	0.577	0.423
M06.83 Other specified rheumatoid arthritis (Forearm)	0.577	0.423
M06.82 Other specified rheumatoid arthritis (Upper arm)	0.577	0.423
M06.81 Other specified rheumatoid arthritis (Shoulder region)	0.577	0.423
M06.80 Other specified rheumatoid arthritis (Multiple sites)	0.577	0.423
M12 Other specific arthropathies	0.580	0.420
M09 Juvenile arthritis in diseases classified elsewhere	0.580	0.420
M08 Juvenile arthritis	0.580	0.420
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.582	0.418
M11 Other crystal arthropathies	0.583	0.417
E16.9 Disorder of pancreatic internal secretion, unspecified	0.588	0.412
E16.8 Other specified disorders of pancreatic internal secretion	0.588	0.412
E16.4 Abnormal secretion of gastrin	0.588	0.412
E16.3 Increased secretion of glucagon	0.588	0.412
E16.1 Other hypoglycaemia	0.588	0.412
E16.0 Drug-induced hypoglycaemia without coma	0.588	0.412
M06.48 Inflammatory polyarthropathy (Other)	0.598	0.402
M06.47 Inflammatory polyarthropathy (Ankle and foot)	0.598	0.402
M06.46 Inflammatory polyarthropathy (Lower leg)	0.598	0.402
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)	0.598	0.402
M06.44 Inflammatory polyarthropathy (Hand)	0.598	0.402
M06.43 Inflammatory polyarthropathy (Forearm)	0.598	0.402
M06.42 Inflammatory polyarthropathy (Upper arm)	0.598	0.402
M06.41 Inflammatory polyarthropathy (Shoulder region)	0.598	0.402
M14 Arthropathies in other diseases classified elsewhere	0.600	0.400
M07 Psoriatic and enteropathic arthropathies	0.601	0.399
M05.8 Other seropositive rheumatoid arthritis	0.601	0.399
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.601	0.399
M05.2 Rheumatoid vasculitis	0.601	0.399
M05.1 Rheumatoid lung disease	0.601	0.399
M05.0 Felty's syndrome	0.601	0.399
E44.1 Mild protein-energy malnutrition	0.602	0.397
E44.0 Moderate protein-energy malnutrition	0.602	0.397
M06.49 Inflammatory polyarthropathy (Site unspecified)	0.607	0.393
E50.9 Vitamin A deficiency, unspecified	0.613	0.386
E50.8 Other manifestations of vitamin A deficiency	0.613	0.386
E50.7 Other ocular manifestations of vitamin A deficiency	0.613	0.386
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.613	0.386
E50.5 Vitamin A deficiency with night blindness	0.613	0.386
E50.4 Vitamin A deficiency with keratomalacia	0.613	0.386
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.613	0.386
E50.2 Vitamin A deficiency with corneal xerosis	0.613	0.386
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.613	0.386
E50.0 Vitamin A deficiency with conjunctival xerosis	0.613	0.386
E51.9 Thiamine deficiency, unspecified	0.613	0.386
E51.8 Other manifestations of thiamine deficiency	0.613	0.386
E51.2 Wernicke's encephalopathy	0.613	0.386
E51.1 Beriberi	0.613	0.386
E56.9 Vitamin deficiency, unspecified	0.613	0.386
E56.8 Deficiency of other vitamins	0.613	0.386
E56.1 Deficiency of vitamin K	0.613	0.386
E56.0 Deficiency of vitamin E	0.613	0.386
E63.9 Nutritional deficiency, unspecified	0.613	0.386
E63.8 Other specified nutritional deficiencies	0.613	0.386
E63.1 Imbalance of constituents of food intake	0.613	0.386
E63.0 Essential fatty acid [EFA] deficiency	0.613	0.386
E64.9 Sequelae of unspecified nutritional deficiency	0.613	0.386
E64.8 Sequelae of other nutritional deficiencies	0.613	0.386
E64.3 Sequelae of rickets	0.613	0.386
E64.2 Sequelae of vitamin C deficiency	0.613	0.386
E64.1 Sequelae of vitamin A deficiency	0.613	0.386
E64.0 Sequelae of protein-energy malnutrition	0.613	0.386
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.616	0.383
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.616	0.383
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.616	0.383
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.616	0.383
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.616	0.383
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.616	0.383
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.616	0.383
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.616	0.383
M06.40 Inflammatory polyarthropathy (Multiple sites)	0.617	0.383
E61.9 Deficiency of nutrient element, unspecified	0.624	0.375
E61.8 Deficiency of other specified nutrient elements	0.624	0.375
E61.7 Deficiency of multiple nutrient elements	0.624	0.375
E61.6 Vanadium deficiency	0.624	0.375
E61.5 Molybdenum deficiency	0.624	0.375
E61.4 Chromium deficiency	0.624	0.375
E61.3 Manganese deficiency	0.624	0.375
E61.2 Magnesium deficiency	0.624	0.375
E61.0 Copper deficiency	0.624	0.375
E89.0 Postprocedural hypothyroidism	0.629	0.371
E55.0 Rickets, active	0.635	0.364
E14.9 Without complications	0.636	0.364
J45.8 Mixed asthma	0.639	0.361
J45.1 Nonallergic asthma	0.639	0.361
E61.1 Iron deficiency	0.640	0.360
E73 Lactose intolerance	0.642	0.358
M10 Gout	0.654	0.346
E89.2 Postprocedural hypoparathyroidism	0.660	0.340
M13.9 Arthritis, unspecified	0.661	0.339
J45.0 Predominantly allergic asthma	0.662	0.337
E55.9 Vitamin D deficiency, unspecified	0.666	0.334
E83 Disorders of mineral metabolism	0.666	0.334
E88 Other metabolic disorders	0.671	0.329
E84 Cystic fibrosis	0.671	0.329
E79 Disorders of purine and pyrimidine metabolism	0.671	0.329
E77 Disorders of glycoprotein metabolism	0.671	0.329
E76 Disorders of glycosaminoglycan metabolism	0.671	0.329
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.671	0.329
E72 Other disorders of amino-acid metabolism	0.671	0.329
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.671	0.329
E70 Disorders of aromatic amino-acid metabolism	0.671	0.329
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.671	0.329
M13.0 Polyarthritis, unspecified	0.676	0.324
E85 Amyloidosis	0.676	0.324
M13.8 Other specified arthritis	0.681	0.319
M13.1 Monoarthritis, not elsewhere classified	0.681	0.319
E74 Other disorders of carbohydrate metabolism	0.684	0.316
E86 Volume depletion	0.684	0.316
J33.9 Nasal polyp, unspecified	0.685	0.315
E89.3 Postprocedural hypopituitarism	0.690	0.310
K90.8 Other intestinal malabsorption	0.691	0.309
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.691	0.309
K90.3 Pancreatic steatorrhoea	0.691	0.309
K90.2 Blind loop syndrome, not elsewhere classified	0.691	0.309
K90.1 Tropical sprue	0.691	0.309
E80 Disorders of porphyrin and bilirubin metabolism	0.698	0.302
M08.9 Juvenile arthritis, unspecified	0.698	0.301
M08.8 Other juvenile arthritis	0.698	0.301
M08.4 Pauciarticular juvenile arthritis	0.698	0.301
M08.3 Juvenile polyarthritis (seronegative)	0.698	0.301
M08.2 Juvenile arthritis with systemic onset	0.698	0.301
M08.1 Juvenile ankylosing spondylitis	0.698	0.301
M08.0 Juvenile rheumatoid arthritis	0.698	0.301
M09.8 Juvenile arthritis in other diseases classified elsewhere	0.698	0.301
M09.2 Juvenile arthritis in ulcerative colitis	0.698	0.301
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]	0.698	0.301
M09.0 Juvenile arthritis in psoriasis	0.698	0.301
M12.8 Other specific arthropathies, not elsewhere classified	0.698	0.301
M12.5 Traumatic arthropathy	0.698	0.301
M12.4 Intermittent hydrarthrosis	0.698	0.301
M12.3 Palindromic rheumatism	0.698	0.301
M12.2 Villonodular synovitis (pigmented)	0.698	0.301
M12.1 Kaschin-Beck disease	0.698	0.301
M12.0 Chronic postrheumatic arthropathy [Jaccoud]	0.698	0.301
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.700	0.300
E89.8 Other postprocedural endocrine and metabolic disorders	0.700	0.300
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.700	0.300
E89.5 Postprocedural testicular hypofunction	0.700	0.300
E89.4 Postprocedural ovarian failure	0.700	0.300
E89.1 Postprocedural hypoinsulinaemia	0.700	0.300
J33 Nasal polyp	0.700	0.300
M11.9 Crystal arthropathy, unspecified	0.701	0.299
M11.8 Other specified crystal arthropathies	0.701	0.299
M11.1 Familial chondrocalcinosis	0.701	0.299
M11.0 Hydroxyapatite deposition disease	0.701	0.299
M11.2 Other chondrocalcinosis	0.704	0.296
M14.8 Arthropathies in other specified diseases classified elsewhere	0.713	0.287
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders	0.713	0.287
M14.4 Arthropathy in amyloidosis	0.713	0.287
M14.3 Lipoid dermatoarthritis	0.713	0.287
M14.2 Diabetic arthropathy	0.713	0.287
M14.1 Crystal arthropathy in other metabolic disorders	0.713	0.287
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders	0.713	0.287
M07.6 Other enteropathic arthropathies	0.714	0.286
M07.5 Arthropathy in ulcerative colitis	0.714	0.286
M07.4 Arthropathy in Crohn's disease [regional enteritis]	0.714	0.286
M07.2 Psoriatic spondylitis	0.714	0.286
M07.1 Arthritis mutilans	0.714	0.286
M07.0 Distal interphalangeal psoriatic arthropathy	0.714	0.286
M13.91 Arthritis, unspecified (Shoulder region)	0.714	0.286
M05.09 Felty's syndrome (Site unspecified)	0.714	0.286
M05.08 Felty's syndrome (Other)	0.714	0.286
M05.07 Felty's syndrome (Ankle and foot)	0.714	0.286
M05.06 Felty's syndrome (Lower leg)	0.714	0.286
M05.05 Felty's syndrome (Pelvic region and thigh)	0.714	0.286
M05.04 Felty's syndrome (Hand)	0.714	0.286
M05.03 Felty's syndrome (Forearm)	0.714	0.286
M05.02 Felty's syndrome (Upper arm)	0.714	0.286
M05.01 Felty's syndrome (Shoulder region)	0.714	0.286
M05.00 Felty's syndrome (Multiple sites)	0.714	0.286
M05.19 Rheumatoid lung disease (Site unspecified)	0.714	0.286
M05.18 Rheumatoid lung disease (Other)	0.714	0.286
M05.17 Rheumatoid lung disease (Ankle and foot)	0.714	0.286
M05.16 Rheumatoid lung disease (Lower leg)	0.714	0.286
M05.15 Rheumatoid lung disease (Pelvic region and thigh)	0.714	0.286
M05.14 Rheumatoid lung disease (Hand)	0.714	0.286
M05.13 Rheumatoid lung disease (Forearm)	0.714	0.286
M05.12 Rheumatoid lung disease (Upper arm)	0.714	0.286
M05.11 Rheumatoid lung disease (Shoulder region)	0.714	0.286
M05.10 Rheumatoid lung disease (Multiple sites)	0.714	0.286
M05.29 Rheumatoid vasculitis (Site unspecified)	0.714	0.286
M05.28 Rheumatoid vasculitis (Other)	0.714	0.286
M05.27 Rheumatoid vasculitis (Ankle and foot)	0.714	0.286
M05.26 Rheumatoid vasculitis (Lower leg)	0.714	0.286
M05.25 Rheumatoid vasculitis (Pelvic region and thigh)	0.714	0.286
M05.24 Rheumatoid vasculitis (Hand)	0.714	0.286
M05.23 Rheumatoid vasculitis (Forearm)	0.714	0.286
M05.22 Rheumatoid vasculitis (Upper arm)	0.714	0.286
M05.21 Rheumatoid vasculitis (Shoulder region)	0.714	0.286
M05.20 Rheumatoid vasculitis (Multiple sites)	0.714	0.286
M05.39 Rheumatoid arthritis with involvement of other organs and systems (Site unspecified)	0.714	0.286
M05.38 Rheumatoid arthritis with involvement of other organs and systems (Other)	0.714	0.286
M05.37 Rheumatoid arthritis with involvement of other organs and systems (Ankle and foot)	0.714	0.286
M05.36 Rheumatoid arthritis with involvement of other organs and systems (Lower leg)	0.714	0.286
M05.35 Rheumatoid arthritis with involvement of other organs and systems (Pelvic region and thigh)	0.714	0.286
M05.34 Rheumatoid arthritis with involvement of other organs and systems (Hand)	0.714	0.286
M05.33 Rheumatoid arthritis with involvement of other organs and systems (Forearm)	0.714	0.286
M05.32 Rheumatoid arthritis with involvement of other organs and systems (Upper arm)	0.714	0.286
M05.31 Rheumatoid arthritis with involvement of other organs and systems (Shoulder region)	0.714	0.286
M05.30 Rheumatoid arthritis with involvement of other organs and systems (Multiple sites)	0.714	0.286
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)	0.714	0.286
M05.88 Other seropositive rheumatoid arthritis (Other)	0.714	0.286
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)	0.714	0.286
M05.86 Other seropositive rheumatoid arthritis (Lower leg)	0.714	0.286
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)	0.714	0.286
M05.84 Other seropositive rheumatoid arthritis (Hand)	0.714	0.286
M05.83 Other seropositive rheumatoid arthritis (Forearm)	0.714	0.286
M05.82 Other seropositive rheumatoid arthritis (Upper arm)	0.714	0.286
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)	0.714	0.286
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)	0.714	0.286
E73.9 Lactose intolerance, unspecified	0.715	0.285
K90.9 Intestinal malabsorption, unspecified	0.715	0.285
E83.4 Disorders of magnesium metabolism	0.719	0.281
M13.98 Arthritis, unspecified (Other)	0.724	0.276
J33.0 Polyp of nasal cavity	0.725	0.275
M14.6 Neuropathic arthropathy	0.733	0.267
M13.95 Arthritis, unspecified (Pelvic region and thigh)	0.733	0.266
M07.3 Other psoriatic arthropathies	0.735	0.265
E83.3 Disorders of phosphorus metabolism	0.739	0.261
J33.8 Other polyp of sinus	0.741	0.259
E73.8 Other lactose intolerance	0.743	0.257
E73.1 Secondary lactase deficiency	0.743	0.257
E73.0 Congenital lactase deficiency	0.743	0.257
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.743	0.257
M13.96 Arthritis, unspecified (Lower leg)	0.748	0.252
M10.4 Other secondary gout	0.751	0.248
M10.3 Gout due to impairment of renal function	0.751	0.248
M10.2 Drug-induced gout	0.751	0.248
M10.1 Lead-induced gout	0.751	0.248
M10.0 Idiopathic gout	0.751	0.248
M13.00 Polyarthritis, unspecified (Multiple sites)	0.756	0.244
M13.92 Arthritis, unspecified (Upper arm)	0.757	0.243
M13.97 Arthritis, unspecified (Ankle and foot)	0.758	0.242
E83.9 Disorder of mineral metabolism, unspecified	0.761	0.239
E83.8 Other disorders of mineral metabolism	0.761	0.239
E83.2 Disorders of zinc metabolism	0.761	0.239
E83.0 Disorders of copper metabolism	0.761	0.239
E88.9 Metabolic disorder, unspecified	0.764	0.236
E88.8 Other specified metabolic disorders	0.764	0.236
E88.3 Tumour lysis syndrome	0.764	0.236
E88.1 Lipodystrophy, not elsewhere classified	0.764	0.236
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.764	0.236
E70.8 Other disorders of aromatic amino-acid metabolism	0.764	0.236
E70.3 Albinism	0.764	0.236
E70.2 Disorders of tyrosine metabolism	0.764	0.236
E70.1 Other hyperphenylalaninaemias	0.764	0.236
E70.0 Classical phenylketonuria	0.764	0.236
E71.3 Disorders of fatty-acid metabolism	0.764	0.236
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.764	0.236
E71.1 Other disorders of branched-chain amino-acid metabolism	0.764	0.236
E71.0 Maple-syrup-urine disease	0.764	0.236
E72.9 Disorder of amino-acid metabolism, unspecified	0.764	0.236
E72.8 Other specified disorders of amino-acid metabolism	0.764	0.236
E72.5 Disorders of glycine metabolism	0.764	0.236
E72.4 Disorders of ornithine metabolism	0.764	0.236
E72.3 Disorders of lysine and hydroxylysine metabolism	0.764	0.236
E72.2 Disorders of urea cycle metabolism	0.764	0.236
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.764	0.236
E72.0 Disorders of amino-acid transport	0.764	0.236
E75.6 Lipid storage disorder, unspecified	0.764	0.236
E75.5 Other lipid storage disorders	0.764	0.236
E75.4 Neuronal ceroid lipofuscinosis	0.764	0.236
E75.3 Sphingolipidosis, unspecified	0.764	0.236
E75.2 Other sphingolipidosis	0.764	0.236
E75.1 Other gangliosidosis	0.764	0.236
E75.0 GM2 gangliosidosis	0.764	0.236
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.764	0.236
E76.8 Other disorders of glucosaminoglycan metabolism	0.764	0.236
E76.3 Mucopolysaccharidosis, unspecified	0.764	0.236
E76.2 Other mucopolysaccharidoses	0.764	0.236
E76.1 Mucopolysaccharidosis, type II	0.764	0.236
E76.0 Mucopolysaccharidosis, type I	0.764	0.236
E77.9 Disorder of glycoprotein metabolism, unspecified	0.764	0.236
E77.8 Other disorders of glycoprotein metabolism	0.764	0.236
E77.1 Defects in glycoprotein degradation	0.764	0.236
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.764	0.236
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.764	0.236
E79.8 Other disorders of purine and pyrimidine metabolism	0.764	0.236
E79.1 Lesch-Nyhan syndrome	0.764	0.236
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.764	0.236
E84.9 Cystic fibrosis, unspecified	0.764	0.236

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations