TreeWAS – Variant ID: rs4147302

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E03.9 Hypothyroidism, unspecified	1.000	0.000	0.000
E03 Other hypothyroidism	0.377	0.622	0.001
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.271	0.729	0.001
E03.5 Myxoedema coma	0.271	0.729	0.001
E03.4 Atrophy of thyroid (acquired)	0.271	0.729	0.001
E03.3 Postinfectious hypothyroidism	0.271	0.729	0.001
E03.1 Congenital hypothyroidism without goitre	0.271	0.729	0.001
E03.0 Congenital hypothyroidism with diffuse goitre	0.271	0.729	0.001
E03.8 Other specified hypothyroidism	0.222	0.777	0.001
E00-E07 Disorders of thyroid gland	0.070	0.929	0.001
E07 Other disorders of thyroid	0.057	0.943	0.001
E06 Thyroiditis	0.056	0.943	0.001
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.050	0.949	0.001
E00 Congenital iodine-deficiency syndrome	0.050	0.949	0.001
E02 Subclinical iodine-deficiency hypothyroidism	0.050	0.949	0.001
E07.9 Disorder of thyroid, unspecified	0.050	0.950	0.000
E06.9 Thyroiditis, unspecified	0.044	0.955	0.000
E06.3 Autoimmune thyroiditis	0.043	0.957	0.000
E07.1 Dyshormogenetic goitre	0.041	0.959	0.001
E07.0 Hypersecretion of calcitonin	0.041	0.959	0.001
E06.5 Other chronic thyroiditis	0.040	0.959	0.001
E06.4 Drug-induced thyroiditis	0.040	0.959	0.001
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.040	0.959	0.001
E06.1 Subacute thyroiditis	0.040	0.959	0.001
E06.0 Acute thyroiditis	0.040	0.959	0.001
E07.8 Other specified disorders of thyroid	0.036	0.963	0.001
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.036	0.963	0.001
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.036	0.963	0.001
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.036	0.963	0.001
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.036	0.963	0.001
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.036	0.963	0.001
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.036	0.963	0.001
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.036	0.963	0.001
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.036	0.963	0.001
E05 Thyrotoxicosis [hyperthyroidism]	0.027	0.972	0.001
E05.8 Other thyrotoxicosis	0.020	0.980	0.001
E05.5 Thyroid crisis or storm	0.020	0.980	0.001
E05.4 Thyrotoxicosis factitia	0.020	0.980	0.001
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.020	0.980	0.001
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.020	0.980	0.001
E05.9 Thyrotoxicosis, unspecified	0.019	0.981	0.000
L40.9 Psoriasis, unspecified	0.017	0.983	0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.016	0.984	0.001
E04 Other non-toxic goitre	0.006	0.988	0.007
O70.1 Second degree perineal laceration during delivery	0.000	0.988	0.012
G43.1 Migraine with aura [classical migraine]	0.012	0.988	0.000
G43.9 Migraine, unspecified	0.011	0.989	0.000
G43 Migraine	0.011	0.989	0.000
E05.0 Thyrotoxicosis with diffuse goitre	0.010	0.989	0.001
L40 Psoriasis	0.011	0.989	0.000
E04.8 Other specified non-toxic goitre	0.004	0.991	0.005
E04.1 Non-toxic single thyroid nodule	0.001	0.991	0.008
E04.0 Non-toxic diffuse goitre	0.004	0.991	0.005
L40.5 Arthropathic psoriasis	0.009	0.991	0.000
G43.8 Other migraine	0.009	0.991	0.000
G43.3 Complicated migraine	0.008	0.992	0.000
G43.2 Status migrainosus	0.008	0.992	0.000
G43.0 Migraine without aura [common migraine]	0.008	0.992	0.000
L40.8 Other psoriasis	0.008	0.992	0.000
L40.4 Guttate psoriasis	0.008	0.992	0.000
L40.3 Pustulosis palmaris et plantaris	0.008	0.992	0.000
L40.2 Acrodermatitis continua	0.008	0.992	0.000
L40.1 Generalised pustular psoriasis	0.008	0.992	0.000
L40.0 Psoriasis vulgaris	0.008	0.992	0.000
E04.9 Non-toxic goitre, unspecified	0.001	0.992	0.006
I20.0 Unstable angina	0.000	0.992	0.008
E04.2 Non-toxic multinodular goitre	0.001	0.993	0.006
E14.9 Without complications	0.000	0.994	0.006
G40 Epilepsy	0.005	0.995	0.000
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures	0.005	0.995	0.000
G40.5 Special epileptic syndromes	0.005	0.995	0.000
M54.59 Low back pain (Site unspecified)	0.000	0.995	0.005
G40.7 Petit mal, unspecified, without grand mal seizures	0.005	0.995	0.000
G40.3 Generalised idiopathic epilepsy and epileptic syndromes	0.005	0.995	0.000
G40.0 Localisation-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localised onset	0.005	0.995	0.000
G40.8 Other epilepsy	0.004	0.995	0.000
G40-G47 Episodic and paroxysmal disorders	0.005	0.995	0.000
N81.6 Rectocele	0.004	0.996	0.000
G40.6 Grand mal seizures, unspecified (with or without petit mal)	0.004	0.996	0.000
N30.9 Cystitis, unspecified	0.004	0.996	0.000
G40.4 Other generalised epilepsy and epileptic syndromes	0.004	0.996	0.000
N81.1 Cystocele	0.004	0.996	0.000
C19 Malignant neoplasm of rectosigmoid junction	0.004	0.996	0.000
C25.9 Pancreas, unspecified	0.004	0.996	0.000
E46 Unspecified protein-energy malnutrition	0.004	0.996	0.000
G40.2 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures	0.003	0.996	0.000
G41 Status epilepticus	0.003	0.996	0.000
G46 Vascular syndromes of brain in cerebrovascular diseases	0.003	0.996	0.000
L40-L45 Papulosquamous disorders	0.003	0.996	0.000
C25 Malignant neoplasm of pancreas	0.003	0.997	0.000
E28.2 Polycystic ovarian syndrome	0.003	0.997	0.000
C15-C26 Malignant neoplasms of digestive organs	0.003	0.997	0.000
G44 Other headache syndromes	0.003	0.997	0.000
N81.5 Vaginal enterocele	0.003	0.997	0.000
E40-E46 Malnutrition	0.003	0.997	0.000
R06.5 Mouth breathing	0.003	0.997	0.000
C15.9 Oesophagus, unspecified	0.003	0.997	0.000
C26 Malignant neoplasm of other and ill-defined digestive organs	0.003	0.997	0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts	0.003	0.997	0.000
C22.0 Liver cell carcinoma	0.003	0.997	0.000
C25.3 Pancreatic duct	0.003	0.997	0.000
C21 Malignant neoplasm of anus and anal canal	0.003	0.997	0.000
N81 Female genital prolapse	0.003	0.997	0.000
G44.0 Cluster headache syndrome	0.003	0.997	0.000
G93.2 Benign intracranial hypertension	0.003	0.997	0.000
C15 Malignant neoplasm of oesophagus	0.003	0.997	0.000
G41.9 Status epilepticus, unspecified	0.003	0.997	0.000
G41.8 Other status epilepticus	0.003	0.997	0.000
G41.2 Complex partial status epilepticus	0.003	0.997	0.000
G41.1 Petit mal status epilepticus	0.003	0.997	0.000
G41.0 Grand mal status epilepticus	0.003	0.997	0.000
C25.2 Tail of pancreas	0.003	0.997	0.000
O20.9 Haemorrhage in early pregnancy, unspecified	0.003	0.997	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.003	0.997	0.000
G46.8 Other vascular syndromes of brain in cerebrovascular diseases	0.003	0.997	0.000
G46.7 Other lacunar syndromes	0.003	0.997	0.000
G46.6 Pure sensory lacunar syndrome	0.003	0.997	0.000
G46.5 Pure motor lacunar syndrome	0.003	0.997	0.000
G46.4 Cerebellar stroke syndrome	0.003	0.997	0.000
G46.3 Brain stem stroke syndrome	0.003	0.997	0.000
G46.2 Posterior cerebral artery syndrome	0.003	0.997	0.000
G46.1 Anterior cerebral artery syndrome	0.003	0.997	0.000
G46.0 Middle cerebral artery syndrome	0.003	0.997	0.000
L44 Other papulosquamous disorders	0.003	0.997	0.000
L41 Parapsoriasis	0.003	0.997	0.000
L45 Papulosquamous disorders in diseases classified elsewhere	0.003	0.997	0.000
L42 Pityriasis rosea	0.003	0.997	0.000
E14 Unspecified diabetes mellitus	0.000	0.997	0.003
C25.8 Overlapping lesion of pancreas	0.003	0.997	0.000
C25.7 Other parts of pancreas	0.003	0.997	0.000
C25.4 Endocrine pancreas	0.003	0.997	0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system	0.003	0.997	0.000
D43.1 Brain, infratentorial	0.003	0.997	0.000
M54.99 Dorsalgia, unspecified (Site unspecified)	0.000	0.997	0.003
Z93.2 Ileostomy status	0.003	0.997	0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract	0.003	0.997	0.000
D43.4 Spinal cord	0.003	0.997	0.000
G93.5 Compression of brain	0.003	0.997	0.000
C25.1 Body of pancreas	0.003	0.997	0.000
C26.0 Intestinal tract, part unspecified	0.003	0.997	0.000
Y42.7 Androgens and anabolic congeners	0.003	0.997	0.000
C26.9 Ill-defined sites within the digestive system	0.002	0.997	0.000
N81.0 Female urethrocele	0.003	0.997	0.000
C17 Malignant neoplasm of small intestine	0.003	0.997	0.000
C21.1 Anal canal	0.002	0.997	0.000
F06.7 Mild cognitive disorder	0.003	0.997	0.000
C21.0 Anus, unspecified	0.002	0.997	0.000
C25.0 Head of pancreas	0.002	0.997	0.000
D43.2 Brain, unspecified	0.003	0.997	0.000
G44.4 Drug-induced headache, not elsewhere classified	0.002	0.997	0.000
G44.3 Chronic posttraumatic headache	0.002	0.997	0.000
G44.1 Vascular headache, not elsewhere classified	0.002	0.997	0.000
R47.8 Other and unspecified speech disturbances	0.000	0.997	0.003
E44 Protein-energy malnutrition of moderate and mild degree	0.002	0.997	0.000
E45 Retarded development following protein-energy malnutrition	0.002	0.997	0.000
E43 Unspecified severe protein-energy malnutrition	0.002	0.997	0.000
E42 Marasmic kwashiorkor	0.002	0.997	0.000
E41 Nutritional marasmus	0.002	0.997	0.000
E40 Kwashiorkor	0.002	0.997	0.000
C23 Malignant neoplasm of gallbladder	0.002	0.997	0.000
C15.3 Upper third of oesophagus	0.002	0.998	0.000
D37.7 Other digestive organs	0.002	0.998	0.000
Q63.0 Accessory kidney	0.002	0.998	0.000
E28 Ovarian dysfunction	0.002	0.998	0.000
G44.8 Other specified headache syndromes	0.002	0.998	0.000
Y42.0 Glucocorticoids and synthetic analogs	0.002	0.998	0.000
N81.3 Complete uterovaginal prolapse	0.002	0.998	0.000
C22.7 Other specified carcinomas of liver	0.002	0.998	0.000
C22.4 Other sarcomas of liver	0.002	0.998	0.000
C22.3 Angiosarcoma of liver	0.002	0.998	0.000
C22.2 Hepatoblastoma	0.002	0.998	0.000
G93 Other disorders of brain	0.002	0.998	0.000
C22.9 Liver, unspecified	0.002	0.998	0.000
C26.8 Overlapping lesion of digestive system	0.002	0.998	0.000
C26.1 Spleen	0.002	0.998	0.000
C21.8 Overlapping lesion of rectum, anus and anal canal	0.002	0.998	0.000
C21.2 Cloacogenic zone	0.002	0.998	0.000
G93.4 Encephalopathy, unspecified	0.002	0.998	0.000
O70 Perineal laceration during delivery	0.000	0.998	0.002
C15.8 Overlapping lesion of oesophagus	0.002	0.998	0.000
C15.2 Abdominal part of oesophagus	0.002	0.998	0.000
C15.1 Thoracic part of oesophagus	0.002	0.998	0.000
C15.0 Cervical part of oesophagus	0.002	0.998	0.000
I27.2 Other secondary pulmonary hypertension	0.002	0.998	0.000
C24.0 Extrahepatic bile duct	0.002	0.998	0.000
C43.7 Malignant melanoma of lower limb, including hip	0.002	0.998	0.000
E14.8 With unspecified complications	0.000	0.998	0.002
E14.7 With multiple complications	0.000	0.998	0.002
E14.6 With other specified complications	0.000	0.998	0.002
E14.5 With peripheral circulatory complications	0.000	0.998	0.002
E14.4 With neurological complications	0.000	0.998	0.002
E14.2 Withrenal complications	0.000	0.998	0.002
E14.1 With ketoacidosis	0.000	0.998	0.002
E14.0 With coma	0.000	0.998	0.002
J69.0 Pneumonitis due to food and vomit	0.002	0.998	0.000
L41.9 Parapsoriasis, unspecified	0.002	0.998	0.000
L41.8 Other parapsoriasis	0.002	0.998	0.000
L41.5 Retiform parapsoriasis	0.002	0.998	0.000
L41.4 Large plaque parapsoriasis	0.002	0.998	0.000
L41.3 Small plaque parapsoriasis	0.002	0.998	0.000
L41.2 Lymphomatoid papulosis	0.002	0.998	0.000
L41.1 Pityriasis lichenoides chronica	0.002	0.998	0.000
L41.0 Pityriasis lichenoides et varioliformis acuta	0.002	0.998	0.000
L44.9 Papulosquamous disorder, unspecified	0.002	0.998	0.000
L44.8 Other specified papulosquamous disorders	0.002	0.998	0.000
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]	0.002	0.998	0.000
L44.3 Lichen ruber moniliformis	0.002	0.998	0.000
L44.2 Lichen striatus	0.002	0.998	0.000
L44.1 Lichen nitidus	0.002	0.998	0.000
L44.0 Pityriasis rubra pilaris	0.002	0.998	0.000
N81.8 Other female genital prolapse	0.002	0.998	0.000
D41.4 Bladder	0.002	0.998	0.000
C16 Malignant neoplasm of stomach	0.002	0.998	0.000
D43.9 Central nervous system, unspecified	0.002	0.998	0.000
D43.7 Other parts of central nervous system	0.002	0.998	0.000
D43.3 Cranial nerves	0.002	0.998	0.000
C24.9 Biliary tract, unspecified	0.002	0.998	0.000
D43.0 Brain, supratentorial	0.002	0.998	0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.002	0.998	0.000
C22.1 Intrahepatic bile duct carcinoma	0.002	0.998	0.000
C24.8 Overlapping lesion of biliary tract	0.002	0.998	0.000
E14.3 With ophthalmic complications	0.000	0.998	0.002
E28.3 Primary ovarian failure	0.002	0.998	0.000
K41.9 Unilateral or unspecified femoral hernia, without obstruction or gangrene	0.000	0.998	0.002
L43 Lichen planus	0.002	0.998	0.000
C17.9 Small intestine, unspecified	0.002	0.998	0.000
C17.8 Overlapping lesion of small intestine	0.002	0.998	0.000
C17.3 Meckel's diverticulum	0.002	0.998	0.000
C17.2 Ileum	0.002	0.998	0.000
C17.1 Jejunum	0.002	0.998	0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease	0.002	0.998	0.000
C15.5 Lower third of oesophagus	0.002	0.998	0.000
C16.5 Lesser curvature of stomach, unspecified	0.002	0.998	0.000
C24.1 Ampulla of Vater	0.002	0.998	0.000
C17.0 Duodenum	0.002	0.998	0.000
E44.1 Mild protein-energy malnutrition	0.002	0.998	0.000
E44.0 Moderate protein-energy malnutrition	0.002	0.998	0.000
K51.4 Pseudopolyposis of colon	0.000	0.998	0.002
R59.1 Generalised enlarged lymph nodes	0.002	0.998	0.000
O70.2 Third degree perineal laceration during delivery	0.000	0.998	0.002
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.002	0.998	0.000
E28.9 Ovarian dysfunction, unspecified	0.002	0.998	0.000
E28.8 Other ovarian dysfunction	0.002	0.998	0.000
E28.1 Androgen excess	0.002	0.998	0.000
E28.0 Oestrogen excess	0.002	0.998	0.000
Y40.8 Other systemic antibiotics	0.002	0.998	0.000
Y53.1 Other antacids and anti-gastric-secretion drugs	0.002	0.998	0.000
Y56.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.002	0.998	0.000
F00.9 Dementia in Alzheimer's disease, unspecified	0.002	0.998	0.000
D37-D48 Neoplasms of uncertain or unknown behaviour	0.002	0.998	0.000
G93.1 Anoxic brain damage, not elsewhere classified	0.002	0.998	0.000
N81.9 Female genital prolapse, unspecified	0.002	0.998	0.000
D37.1 Stomach	0.002	0.998	0.000
G93.7 Reye's syndrome	0.002	0.998	0.000
N94.6 Dysmenorrhoea, unspecified	0.002	0.998	0.000
O70.9 Perineal laceration during delivery, unspecified	0.000	0.998	0.002
D41 Neoplasm of uncertain or unknown behaviour of urinary organs	0.002	0.998	0.000
Y53 Agents primarily affecting the gastro-intestinal system	0.002	0.998	0.000
D37.0 Lip, oral cavity and pharynx	0.002	0.998	0.000
E83.1 Disorders of iron metabolism	0.000	0.998	0.002
G93.3 Postviral fatigue syndrome	0.002	0.998	0.000
Y84.0 Cardiac catheterisation	0.002	0.998	0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs	0.002	0.998	0.000
G93.0 Cerebral cysts	0.002	0.998	0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified	0.002	0.998	0.000
C20 Malignant neoplasm of rectum	0.002	0.998	0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands	0.002	0.998	0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.002	0.998	0.000
K51.8 Other ulcerative colitis	0.000	0.998	0.002
D46 Myelodysplastic syndromes	0.002	0.998	0.000
C16.8 Overlapping lesion of stomach	0.002	0.998	0.000
C16.6 Greater curvature of stomach, unspecified	0.002	0.998	0.000
C16.4 Pylorus	0.002	0.998	0.000
C16.3 Pyloric antrum	0.002	0.998	0.000
C16.2 Body of stomach	0.002	0.998	0.000
C16.1 Fundus of stomach	0.002	0.998	0.000
F00 Dementia in Alzheimer's disease	0.002	0.998	0.000
Y40 Systemic antibiotics	0.002	0.998	0.000
Y42.9 Other and unspecified hormone antagonists	0.002	0.998	0.000
Y42.4 Oral contraceptives	0.002	0.998	0.000
Y42.2 Antithyroid drugs	0.002	0.998	0.000
Y42.1 Thyroid hormones and substitutes	0.002	0.998	0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.002	0.998	0.000
D44.4 Craniopharyngeal duct	0.002	0.998	0.000
E13.9 Without complications	0.002	0.998	0.000
F02.3 Dementia in Parkinson's disease	0.002	0.998	0.000
L43.8 Other lichen planus	0.002	0.998	0.000
L43.3 Subacute (active) lichen planus	0.002	0.998	0.000
L43.2 Lichenoid drug reaction	0.002	0.998	0.000
L43.1 Bullous lichen planus	0.002	0.998	0.000
L43.0 Hypertrophic lichen planus	0.002	0.998	0.000
N30.3 Trigonitis	0.002	0.998	0.000
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.002	0.998	0.000
F02 Dementia in other diseases classified elsewhere	0.002	0.998	0.000
C15.4 Middle third of oesophagus	0.001	0.998	0.000
D46.9 Myelodysplastic syndrome, unspecified	0.002	0.998	0.000
F06.9 Unspecified mental disorder due to brain damage and dysfunction and to physical disease	0.002	0.998	0.000
F06.8 Other specified mental disorders due to brain damage and dysfunction and to physical disease	0.002	0.998	0.000
F06.6 Organic emotionally labile [asthenic] disorder	0.002	0.998	0.000
F06.5 Organic dissociative disorder	0.002	0.998	0.000
F06.4 Organic anxiety disorder	0.002	0.998	0.000
F06.3 Organic mood [affective] disorders	0.002	0.998	0.000
F06.2 Organic delusional [schizophrenia-like] disorder	0.002	0.998	0.000
F06.1 Organic catatonic disorder	0.002	0.998	0.000
F06.0 Organic hallucinosis	0.002	0.998	0.000
Y53.4 Other laxatives	0.002	0.998	0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue	0.002	0.998	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.002	0.998	0.000
K51 Ulcerative colitis	0.000	0.998	0.002
N30 Cystitis	0.002	0.998	0.000
Y40.1 Cefalosporins and other -lactam antibiotics	0.002	0.998	0.000
Y54.3 Benzothiadiazine derivatives	0.002	0.998	0.000
F00-F09 Organic, including symptomatic, mental disorders	0.002	0.998	0.000
J92.9 Pleural plaque without asbestos	0.002	0.998	0.000
Y40.9 Systemic antibiotic, unspecified	0.002	0.998	0.000
Y42.5 Other oestrogens and progestogens	0.002	0.998	0.000
E15 Nondiabetic hypoglycaemic coma	0.002	0.998	0.000
F05 Delirium, not induced by alcohol and other psychoactive substances	0.002	0.998	0.000
C71.2 Temporal lobe	0.002	0.998	0.000
D44.3 Pituitary gland	0.002	0.998	0.000
K51.5 Mucosal proctocolitis	0.000	0.998	0.002
N30.8 Other cystitis	0.002	0.998	0.000
Y54.5 Other diuretics	0.002	0.998	0.000
E50-E64 Other nutritional deficiencies	0.002	0.998	0.000
D37.9 Digestive organ, unspecified	0.002	0.998	0.000
H02.1 Ectropion of eyelid	0.002	0.998	0.000
K51.3 Ulcerative (chronic) rectosigmoiditis	0.000	0.998	0.002
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified	0.002	0.998	0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges	0.002	0.998	0.000
Y52 Agents primarily affecting the cardiovascular system	0.002	0.998	0.000
D41.9 Urinary organ, unspecified	0.002	0.998	0.000
D41.7 Other urinary organs	0.002	0.998	0.000
D41.3 Urethra	0.002	0.998	0.000
D41.2 Ureter	0.002	0.998	0.000
D41.1 Renal pelvis	0.002	0.998	0.000
K51.2 Ulcerative (chronic) proctitis	0.000	0.998	0.002
D37.3 Appendix	0.002	0.998	0.000
D48.5 Skin	0.002	0.998	0.000
Y53.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.002	0.998	0.000
Y53.8 Other agents primarily affecting the gastro-intestinal system	0.002	0.998	0.000
Y53.7 Emetics	0.002	0.998	0.000
Y53.6 Antidiarrhoeal drugs	0.002	0.998	0.000
Y53.5 Digestants	0.002	0.998	0.000
Y53.3 Saline and osmotic laxatives	0.002	0.998	0.000
Y53.2 Stimulant laxatives	0.002	0.998	0.000
Y53.0 Histamine H2-receptor antagonists	0.002	0.998	0.000
O70.3 Fourth degree perineal laceration during delivery	0.000	0.998	0.001
I27 Other pulmonary heart diseases	0.002	0.998	0.000
Y49 Psychotropic drugs, not elsewhere classified	0.002	0.998	0.000
C16.0 Cardia	0.002	0.998	0.000
D44.9 Endocrine gland, unspecified	0.001	0.998	0.000
D44.8 Pluriglandular involvement	0.001	0.998	0.000
D44.7 Aortic body and other paraganglia	0.001	0.998	0.000
D44.6 Carotid body	0.001	0.998	0.000
D44.5 Pineal gland	0.001	0.998	0.000
D44.2 Parathyroid gland	0.001	0.998	0.000
D44.1 Adrenal gland	0.001	0.998	0.000
D44.0 Thyroid gland	0.001	0.998	0.000
D46.2 Refractory anaemia with excess of blasts	0.002	0.998	0.000
F00.0 Dementia in Alzheimer's disease with early onset	0.002	0.998	0.000
F02.8 Dementia in other specified diseases classified elsewhere	0.002	0.998	0.000
F05.1 Delirium superimposed on dementia	0.002	0.998	0.000
G04.9 Encephalitis, myelitis and encephalomyelitis, unspecified	0.002	0.998	0.000
G30.9 Alzheimer's disease, unspecified	0.002	0.998	0.000
G95.8 Other specified diseases of spinal cord	0.002	0.998	0.000
R47.1 Dysarthria and anarthria	0.000	0.998	0.002
Y49.2 Other and unspecified antidepressants	0.002	0.998	0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs	0.002	0.998	0.000
D46.7 Other myelodysplastic syndromes	0.001	0.998	0.000
D46.6 Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality	0.001	0.998	0.000
D46.5 Refractory anaemia with multi-lineage dysplasia	0.001	0.998	0.000
D46.4 Refractory anaemia, unspecified	0.001	0.998	0.000
D46.3 Refractory anaemia with excess of blasts with transformation	0.001	0.998	0.000
D46.1 Refractory anaemia with sideroblasts	0.001	0.998	0.000
D46.0 Refractory anaemia without sideroblasts, so stated	0.001	0.998	0.000
D47.1 Chronic myeloproliferative disease	0.002	0.998	0.000
I27.9 Pulmonary heart disease, unspecified	0.002	0.998	0.000
Y56.9 Topical agent, unspecified	0.001	0.998	0.000
Y56.8 Other topical agents	0.001	0.998	0.000
Y56.7 Dental drugs, topically applied	0.001	0.998	0.000
Y56.6 Otorhinolaryngological drugs and preparations	0.001	0.998	0.000
Y56.5 Ophthalmological drugs and preparations	0.001	0.998	0.000
Y56.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.001	0.998	0.000
Y56.3 Emollients, demulcents and protectants	0.001	0.998	0.000
Y56.2 Local astringents and local detergents	0.001	0.998	0.000
Y56.1 Antipruritics	0.001	0.998	0.000
Z00.5 Examination of potential donor of organ and tissue	0.002	0.998	0.000
Y48 Anaesthetics and therapeutic gases	0.002	0.998	0.000
Y46 Antiepileptics and anti-Parkinsonism drugs	0.002	0.998	0.000
G90-G99 Other disorders of the nervous system	0.002	0.998	0.000
F00.2 Dementia in Alzheimer's disease, atypical or mixed type	0.001	0.998	0.000
F00.1 Dementia in Alzheimer's disease with late onset	0.001	0.998	0.000
G93.9 Disorder of brain, unspecified	0.002	0.998	0.000
N30.4 Irradiation cystitis	0.002	0.998	0.000
Y40.7 Antifungal antibiotics, systemically used	0.001	0.998	0.000
Y40.6 Rifamycins	0.001	0.998	0.000
Y40.5 Aminoglycosides	0.001	0.998	0.000
Y40.4 Tetracyclines	0.001	0.998	0.000
Y40.2 Chloramphenicol group	0.001	0.998	0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs	0.002	0.998	0.000
G95 Other diseases of spinal cord	0.002	0.998	0.000
Y47 Sedatives, hypnotics and antianxiety drugs	0.002	0.998	0.000
E20-E35 Disorders of other endocrine glands	0.002	0.998	0.000
M71.26 Synovial cyst of popliteal space [Baker]-Lower Leg	0.002	0.998	0.000
D37.2 Small intestine	0.001	0.998	0.000
D47.2 Monoclonal gammopathy	0.002	0.998	0.000
F05.8 Other delirium	0.002	0.998	0.000
G44.2 Tension-type headache	0.001	0.998	0.000
G93.6 Cerebral oedema	0.001	0.998	0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified	0.002	0.998	0.000
G93.8 Other specified disorders of brain	0.001	0.998	0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes	0.001	0.998	0.000
Y54.9 Mineral salts, not elsewhere classified	0.001	0.998	0.000
Y54.8 Agents affecting uric acid metabolism	0.001	0.998	0.000
Y54.7 Agents affecting calcification	0.001	0.998	0.000
Y54.6 Electrolytic, caloric and water-balance agents	0.001	0.998	0.000
Y54.4 Loop [high-ceiling] diuretics	0.001	0.998	0.000
Y54.2 Carbonic-anhydrase inhibitors	0.001	0.998	0.000
Y54.1 Mineralocorticoid antagonists [aldosterone antagonists]	0.001	0.998	0.000
Y54.0 Mineralocorticoids	0.001	0.998	0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites	0.002	0.998	0.000
M13.94 Arthritis, unspecified (Hand)	0.000	0.998	0.002
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.002	0.998	0.000
F02.4 Dementia in human immunodeficiency virus [HIV] disease	0.001	0.998	0.000
F02.2 Dementia in Huntington's disease	0.001	0.998	0.000
F02.1 Dementia in Creutzfeldt-Jakob disease	0.001	0.998	0.000
F02.0 Dementia in Pick's disease	0.001	0.998	0.000
G95.9 Disease of spinal cord, unspecified	0.002	0.998	0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.001	0.998	0.000
O20 Haemorrhage in early pregnancy	0.002	0.998	0.000
Y59 Other and unspecified vaccines and biological substances	0.001	0.998	0.000
Y58 Bacterial vaccines	0.001	0.998	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.001	0.998	0.000
Y50 Central nervous system stimulants, not elsewhere classified	0.001	0.998	0.000
D33.3 Cranial nerves	0.002	0.998	0.000
D47.9 Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified	0.001	0.998	0.000
D47.7 Other specified neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue	0.001	0.998	0.000
D47.5 Chronic eosinophilic leukaemia [hypereosinophilic syndrome]	0.001	0.998	0.000
D47.0 Histiocytic and mast cell tumours of uncertain and unknown behaviour	0.001	0.998	0.000
G72.9 Myopathy, unspecified	0.001	0.998	0.000
G96.8 Other specified disorders of central nervous system	0.001	0.998	0.000
K51.1 Ulcerative (chronic) ileocolitis	0.000	0.998	0.001
Y84.6 Urinary catheterisation	0.002	0.998	0.000
R80 Isolated proteinuria	0.000	0.998	0.002
D39 Neoplasm of uncertain or unknown behaviour of female genital organs	0.001	0.998	0.000
G96 Other disorders of central nervous system	0.001	0.998	0.000
S92.30 Fracture of metatarsal bone (closed)	0.000	0.998	0.001
F10.0 Acute intoxication	0.000	0.998	0.002
I27.0 Primary pulmonary hypertension	0.002	0.998	0.000
Y46.4 Iminostilbenes	0.001	0.998	0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction	0.001	0.998	0.000
F09 Unspecified organic or symptomatic mental disorder	0.001	0.998	0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances	0.001	0.998	0.000
Q63 Other congenital malformations of kidney	0.001	0.998	0.000
D38.0 Larynx	0.001	0.998	0.000
D42.9 Meninges, unspecified	0.001	0.998	0.000
D42.1 Spinal meninges	0.001	0.998	0.000
D42.0 Cerebral meninges	0.001	0.998	0.000
D47.4 Osteomyelofibrosis	0.001	0.998	0.000
F05.0 Delirium not superimposed on dementia, so described	0.001	0.998	0.000
I67.9 Cerebrovascular disease, unspecified	0.000	0.998	0.002
Y48.3 Local anaesthetics	0.001	0.998	0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system	0.001	0.998	0.000
Y52.8 Antivaricose drugs, including sclerosing agents	0.001	0.998	0.000
Y52.7 Peripheral vasodilators	0.001	0.998	0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action	0.001	0.998	0.000
E64 Sequelae of malnutrition and other nutritional deficiencies	0.001	0.998	0.000
E63 Other nutritional deficiencies	0.001	0.998	0.000
E56 Other vitamin deficiencies	0.001	0.998	0.000
E51 Thiamine deficiency	0.001	0.998	0.000
E50 Vitamin A deficiency	0.001	0.998	0.000
E60 Dietary zinc deficiency	0.001	0.998	0.000
E59 Dietary selenium deficiency	0.001	0.998	0.000
E58 Dietary calcium deficiency	0.001	0.998	0.000
E54 Ascorbic acid deficiency	0.001	0.998	0.000
E52 Niacin deficiency [pellagra]	0.001	0.998	0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified	0.001	0.998	0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum	0.002	0.998	0.000
D40.0 Prostate	0.001	0.998	0.000
Y52.3 Coronary vasodilators, not elsewhere classified	0.001	0.998	0.000
R47 Speech disturbances, not elsewhere classified	0.000	0.998	0.002
Y51 Drugs primarily affecting the autonomic nervous system	0.001	0.998	0.000
C18.0 Caecum	0.001	0.998	0.000
D47.3 Essential (haemorrhagic) thrombocythaemia	0.001	0.998	0.000
G04 Encephalitis, myelitis and encephalomyelitis	0.001	0.998	0.000
F05.9 Delirium, unspecified	0.001	0.999	0.000
G97.8 Other postprocedural disorders of nervous system	0.001	0.999	0.000
I27.8 Other specified pulmonary heart diseases	0.001	0.999	0.000
I27.1 Kyphoscoliotic heart disease	0.001	0.999	0.000
Y40.3 Macrolides	0.001	0.999	0.000
Y47.1 Benzodiazepines	0.001	0.999	0.000
Y49.9 Psychotropic drug, unspecified	0.001	0.999	0.000
Y49.8 Other psychotropic drugs, not elsewhere classified	0.001	0.999	0.000
Y49.7 Psychostimulants with abuse potential	0.001	0.999	0.000
Y49.6 Psychodysleptics [hallucinogens]	0.001	0.999	0.000
Y49.4 Butyrophenone and thioxanthene neuroleptics	0.001	0.999	0.000
Y49.3 Phenothiazine antipsychotics and neuroleptics	0.001	0.999	0.000
Y49.1 Monoamine-oxidase-inhibitor antidepressants	0.001	0.999	0.000
Y49.0 Tricyclic and tetracyclic antidepressants	0.001	0.999	0.000
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.001	0.999	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations