TreeWAS – Variant ID: rs415430

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
K60.2 Anal fissure, unspecified	0.000	0.080	0.920
K60.1 Chronic anal fissure	0.000	0.105	0.895
K60 Fissure and fistula of anal and rectal regions	0.000	0.108	0.892
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.842	0.158	0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma	0.840	0.160	0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type	0.834	0.166	0.000
E66.8 Other obesity	0.000	0.177	0.823
E66.9 Obesity, unspecified	0.000	0.181	0.819
E66 Obesity	0.000	0.182	0.818
C82 Follicular [nodular] non-Hodgkin's lymphoma	0.794	0.206	0.000
M16.9 Coxarthrosis, unspecified	0.000	0.207	0.793
M16.1 Other primary coxarthrosis	0.000	0.210	0.790
M16 Coxarthrosis [arthrosis of hip]	0.000	0.211	0.789
C88 Malignant immunoproliferative diseases	0.774	0.226	0.000
C83 Diffuse non-Hodgkin's lymphoma	0.772	0.228	0.000
C84 Peripheral and cutaneous T-cell lymphomas	0.769	0.231	0.000
M20 Acquired deformities of fingers and toes	0.000	0.238	0.762
M20.2 Hallux rigidus	0.000	0.241	0.759
M20.5 Other deformities of toe(s) (acquired)	0.000	0.247	0.753
M20.1 Hallux valgus (acquired)	0.000	0.252	0.748
M16.3 Other dysplastic coxarthrosis	0.000	0.268	0.732
C85.1 B-cell lymphoma, unspecified	0.728	0.272	0.000
C90 Multiple myeloma and malignant plasma cell neoplasms	0.720	0.280	0.000
M20.3 Other deformity of hallux (acquired)	0.000	0.281	0.719
C83.3 Large cell (diffuse)	0.719	0.281	0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified	0.714	0.286	0.000
C88.0 Waldenstrom's macroglobulinaemia	0.708	0.292	0.000
C93 Monocytic leukaemia	0.681	0.319	0.000
C82.1 Mixed small cleaved and large cell, follicular	0.671	0.329	0.000
C84.4 Peripheral T-cell lymphoma	0.661	0.339	0.000
C84.5 Other and unspecified T-cell lymphomas	0.661	0.339	0.000
C82.2 Large cell, follicular	0.660	0.340	0.000
C95 Leukaemia of unspecified cell type	0.659	0.341	0.000
C83.8 Other types of diffuse non-Hodgkin's lymphoma	0.655	0.345	0.000
C91 Lymphoid leukaemia	0.644	0.355	0.000
C86 Other specified types of T/NK-cell lymphoma	0.642	0.358	0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma	0.638	0.362	0.000
K60.4 Rectal fistula	0.000	0.365	0.635
M20.0 Deformity of finger(s)	0.000	0.371	0.629
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]	0.614	0.386	0.000
C90.0 Multiple myeloma	0.612	0.388	0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue	0.604	0.396	0.000
C92 Myeloid leukaemia	0.604	0.396	0.000
C82.0 Small cleaved cell, follicular	0.603	0.397	0.000
C85.0 Lymphosarcoma	0.602	0.398	0.000
C90.3 Solitary plasmacytoma	0.597	0.403	0.000
E66.1 Drug-induced obesity	0.000	0.414	0.586
M16.7 Other secondary coxarthrosis	0.000	0.427	0.573
M16.2 Coxarthrosis resulting from dysplasia, bilateral	0.000	0.427	0.573
C83.5 Lymphoblastic (diffuse)	0.572	0.428	0.000
C94 Other leukaemias of specified cell type	0.570	0.430	0.000
C82.6 Cutaneous follicle centre lymphoma	0.570	0.430	0.000
C82.5 Diffuse follicle centre lymphoma	0.570	0.430	0.000
C84.8 Cutaneous T-cell lymphoma, unspecified	0.568	0.432	0.000
M16.4 Posttraumatic coxarthrosis, bilateral	0.000	0.435	0.565
C93.1 Chronic monocytic leukaemia	0.565	0.435	0.000
C83.2 Mixed small and large cell (diffuse)	0.564	0.436	0.000
C83.1 Small cleaved cell (diffuse)	0.563	0.437	0.000
C95.9 Leukaemia, unspecified	0.558	0.442	0.000
C83.7 Burkitt's tumour	0.556	0.444	0.000
C85.7 Other specified types of non-Hodgkin's lymphoma	0.556	0.444	0.000
C88.9 Malignant immunoproliferative disease, unspecified	0.555	0.445	0.000
C88.7 Other malignant immunoproliferative diseases	0.555	0.445	0.000
C88.3 Immunoproliferative small intestinal disease	0.555	0.445	0.000
C88.2 Gamma heavy chain disease	0.555	0.445	0.000
C88.1 Alpha heavy chain disease	0.555	0.445	0.000
C83.6 Undifferentiated (diffuse)	0.554	0.446	0.000
C83.4 Immunoblastic (diffuse)	0.554	0.446	0.000
C84.9 Mature T/NK-cell lymphoma, unspecified	0.551	0.449	0.000
C84.7 Anaplastic large cell lymphoma, ALK-negative	0.551	0.449	0.000
C84.6 Anaplastic large cell lymphoma, ALK-positive	0.551	0.449	0.000
C84.3 Lymphoepithelioid lymphoma	0.551	0.449	0.000
C84.2 T-zone lymphoma	0.551	0.449	0.000
C84.1 Sezary's diease	0.551	0.449	0.000
C82.7 Other types of follicular non-Hodgkin's lymphoma	0.546	0.454	0.000
E66.0 Obesity due to excess calories	0.000	0.455	0.545
C84.0 Mycosis fungoides	0.538	0.462	0.000
C82.3 Follicular lymphoma grade IIIa	0.533	0.467	0.000
C91.0 Acute lymphoblastic leukaemia	0.532	0.468	0.000
K60.3 Anal fistula	0.000	0.468	0.532
C82.4 Follicular lymphoma grade IIIb	0.530	0.470	0.000
E66.2 Extreme obesity with alveolar hypoventilation	0.000	0.470	0.530
E65-E68 Obesity and other hyperalimentation	0.000	0.478	0.522
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified	0.521	0.479	0.000
M16.6 Other secondary coxarthrosis, bilateral	0.000	0.480	0.520
C81 Hodgkin's disease	0.519	0.481	0.000
K60.0 Acute anal fissure	0.000	0.491	0.508
C90.1 Plasma cell leukaemia	0.504	0.495	0.000
C92.7 Other myeloid leukaemia	0.503	0.497	0.000
C91.4 Hairy-cell leukaemia	0.502	0.498	0.000
C86.5 Angioimmunoblastic T-cell lymphoma	0.498	0.502	0.000
M15-M19 Arthrosis	0.000	0.512	0.488
C93.9 Monocytic leukaemia, unspecified	0.488	0.512	0.000
C93.7 Other monocytic leukaemia	0.488	0.512	0.000
C93.3 Juvenile myelomonocytic leukaemia	0.488	0.512	0.000
C93.2 Subacute monocytic leukaemia	0.488	0.512	0.000
C93.0 Acute monocytic leukaemia	0.488	0.512	0.000
M18 Arthrosis of first carpometacarpal joint	0.000	0.517	0.483
C91.1 Chronic lymphocytic leukaemia	0.478	0.522	0.000
C95.7 Other leukaemia of unspecified cell type	0.472	0.527	0.000
C95.2 Subacute leukaemia of unspecified cell type	0.472	0.527	0.000
M16.5 Other posttraumatic coxarthrosis	0.000	0.537	0.462
C91.8 Mature B-cell leukaemia Burkitt-type	0.462	0.538	0.000
C91.7 Other lymphoid leukaemia	0.462	0.538	0.000
C91.6 Prolymphocytic leukaemia of T-cell type	0.462	0.538	0.000
C91.3 Prolymphocytic leukaemia	0.462	0.538	0.000
C91.2 Subacute lymphocytic leukaemia	0.462	0.538	0.000
C86.6 Primary cutaneous CD30-positive T-cell proliferations	0.460	0.540	0.000
C86.4 Blastic NK-cell lymphoma	0.460	0.540	0.000
C86.3 Subcutaneous panniculitis-like T-cell lymphoma	0.460	0.540	0.000
C86.2 Enteropathy-type (intestinal) T-cell lymphoma	0.460	0.540	0.000
C86.1 Hepatosplenic T-cell lymphoma	0.460	0.540	0.000
C86.0 Extranodal NK/T-cell lymphoma, nasal type	0.460	0.540	0.000
C90.2 Plasmacytoma, extramedullary	0.460	0.540	0.000
M18.1 Other primary arthrosis of first carpometacarpal joint	0.000	0.544	0.456
C92.4 Acute promyelocytic leukaemia	0.453	0.547	0.000
C95.0 Acute leukaemia of unspecified cell type	0.452	0.548	0.000
C92.5 Acute myelomonocytic leukaemia	0.445	0.555	0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified	0.000	0.558	0.442
C91.5 Adult T-cell leukaemia	0.441	0.559	0.000
C92.2 Subacute myeloid leukaemia	0.441	0.559	0.000
C95.1 Chronic leukaemia of unspecified cell type	0.440	0.560	0.000
K60.5 Anorectal fistula	0.000	0.562	0.437
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified	0.433	0.567	0.000
C96.8 Histiocytic sarcoma	0.433	0.567	0.000
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue	0.433	0.567	0.000
C96.6 Unifocal Langerhans-cell histiocytosis	0.433	0.567	0.000
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis	0.433	0.567	0.000
C96.4 Sarcoma of dendritic cells (accessory cells)	0.433	0.567	0.000
C96.3 True histiocytic lymphoma	0.433	0.567	0.000
C96.2 Malignant mast cell tumour	0.433	0.567	0.000
C96.1 Malignant histiocytosis	0.433	0.567	0.000
C96.0 Letterer-Siwe disease	0.433	0.567	0.000
C92.8 Acute myeloid leukaemia with multilineage dysplasia	0.433	0.567	0.000
C92.6 Acute myeloid leukaemia with 11q23-abnormality	0.433	0.567	0.000
C92.3 Myeloid sarcoma	0.433	0.567	0.000
C92.1 Chronic myeloid leukaemia	0.431	0.569	0.000
C94.7 Other specified leukaemias	0.409	0.591	0.000
C94.5 Acute myelofibrosis	0.409	0.591	0.000
C94.3 Mast cell leukaemia	0.409	0.591	0.000
C94.2 Acute megakaryoblastic leukaemia	0.409	0.591	0.000
C94.1 Chronic erythraemia	0.409	0.591	0.000
C94.0 Acute erythraemia and erythroleukaemia	0.409	0.591	0.000
C81.2 Mixed cellularity	0.400	0.600	0.000
C94.6 Myelodysplastic and myeloproliferative disease, not elsewhere classified	0.396	0.604	0.000
C92.9 Myeloid leukaemia, unspecified	0.392	0.608	0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral	0.000	0.610	0.390
C94.4 Acute panmyelosis	0.389	0.611	0.000
E20-E35 Disorders of other endocrine glands	0.000	0.621	0.379
E22 Hyperfunction of pituitary gland	0.000	0.621	0.379
E67 Other hyperalimentation	0.000	0.626	0.374
E68 Sequelae of hyperalimentation	0.000	0.626	0.374
C83.0 Small cell (diffuse)	0.372	0.628	0.000
C81.4 Lymphocyte-rich classical Hodgkin lymphoma	0.372	0.628	0.000
C81.3 Lymphocytic depletion	0.372	0.628	0.000
C81.1 Nodular sclerosis	0.371	0.629	0.000
E22.0 Acromegaly and pituitary gigantism	0.000	0.639	0.361
C81.9 Hodgkin's disease, unspecified	0.360	0.640	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.640	0.360
C91.9 Lymphoid leukaemia, unspecified	0.355	0.644	0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.000	0.653	0.347
M18.5 Other secondary arthrosis of first carpometacarpal joint	0.000	0.654	0.346
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral	0.000	0.654	0.346
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral	0.000	0.654	0.346
E24 Cushing's syndrome	0.000	0.655	0.345
E29 Testicular dysfunction	0.000	0.655	0.345
E34 Other endocrine disorders	0.000	0.655	0.345
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint	0.000	0.655	0.345
E26 Hyperaldosteronism	0.000	0.658	0.342
E65 Localised adiposity	0.000	0.672	0.328
E29.1 Testicular hypofunction	0.000	0.675	0.325
C81.7 Other Hodgkin's disease	0.325	0.675	0.000
E22.1 Hyperprolactinaemia	0.000	0.678	0.322
C81.0 Lymphocytic predominance	0.320	0.680	0.000
E26.0 Primary hyperaldosteronism	0.000	0.689	0.311
C92.0 Acute myeloid leukaemia	0.311	0.689	0.000
E34.0 Carcinoid syndrome	0.000	0.699	0.301
E22.9 Hyperfunction of pituitary gland, unspecified	0.000	0.709	0.291
E24.9 Cushing's syndrome, unspecified	0.000	0.711	0.289
E24.0 Pituitary-dependent Cushing's disease	0.000	0.715	0.285
E34.3 Short stature, not elsewhere classified	0.000	0.718	0.282
E23 Hypofunction and other disorders of pituitary gland	0.000	0.722	0.278
E34.9 Endocrine disorder, unspecified	0.000	0.727	0.273
E22.8 Other hyperfunction of pituitary gland	0.000	0.728	0.272
E35 Disorders of endocrine glands in diseases classified elsewhere	0.000	0.728	0.272
E30 Disorders of puberty, not elsewhere classified	0.000	0.728	0.272
E24.2 Drug-induced Cushing's syndrome	0.000	0.728	0.271
E67.8 Other specified hyperalimentation	0.000	0.731	0.268
E67.3 Hypervitaminosis D	0.000	0.731	0.268
E67.2 Megavitamin-B6 syndrome	0.000	0.731	0.268
E67.1 Hypercarotenaemia	0.000	0.731	0.268
E67.0 Hypervitaminosis A	0.000	0.731	0.268
M20.6 Acquired deformity of toe(s), unspecified	0.000	0.735	0.265
E25 Adrenogenital disorders	0.000	0.736	0.264
E31 Polyglandular dysfunction	0.000	0.739	0.261
E26.9 Hyperaldosteronism, unspecified	0.000	0.742	0.258
E20 Hypoparathyroidism	0.000	0.742	0.258
E24.8 Other Cushing's syndrome	0.000	0.745	0.255
E32 Diseases of thymus	0.000	0.748	0.252
E40-E46 Malnutrition	0.000	0.749	0.251
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.000	0.752	0.248
E24.3 Ectopic ACTH syndrome	0.000	0.752	0.248
E24.1 Nelson's syndrome	0.000	0.752	0.248
E29.8 Other testicular dysfunction	0.000	0.752	0.248
E29.0 Testicular hyperfunction	0.000	0.752	0.248
E34.5 Androgen resistance syndrome	0.000	0.752	0.247
E34.4 Constitutional tall stature	0.000	0.752	0.247
E34.2 Ectopic hormone secretion, not elsewhere classified	0.000	0.752	0.247
E34.1 Other hypersecretion of intestinal hormones	0.000	0.752	0.247
E26.8 Other hyperaldosteronism	0.000	0.755	0.245
E26.1 Secondary hyperaldosteronism	0.000	0.755	0.245
E34.8 Other specified endocrine disorders	0.000	0.770	0.229
E29.9 Testicular dysfunction, unspecified	0.000	0.771	0.229
E23.2 Diabetes insipidus	0.000	0.780	0.220
M20.4 Other hammer toe(s) (acquired)	0.000	0.781	0.219
M19 Other arthrosis	0.000	0.781	0.219
E00-E07 Disorders of thyroid gland	0.000	0.784	0.216
E27 Other disorders of adrenal gland	0.000	0.785	0.215
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.000	0.791	0.208
E06 Thyroiditis	0.000	0.795	0.205
E23.1 Drug-induced hypopituitarism	0.000	0.801	0.199
E23.0 Hypopituitarism	0.000	0.802	0.197
E23.6 Other disorders of pituitary gland	0.000	0.804	0.196
E06.3 Autoimmune thyroiditis	0.000	0.804	0.196
E30.9 Disorder of puberty, unspecified	0.000	0.805	0.195
E30.8 Other disorders of puberty	0.000	0.805	0.195
E30.1 Precocious puberty	0.000	0.805	0.195
E30.0 Delayed puberty	0.000	0.805	0.195
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.000	0.805	0.195
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.000	0.805	0.195
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.000	0.805	0.195
M17 Gonarthrosis [arthrosis of knee]	0.000	0.805	0.195
E50-E64 Other nutritional deficiencies	0.000	0.807	0.193
E07 Other disorders of thyroid	0.000	0.807	0.193
M19.0 Primary arthrosis of other joints	0.000	0.808	0.192
E20.9 Hypoparathyroidism, unspecified	0.000	0.810	0.190
E25.9 Adrenogenital disorder, unspecified	0.000	0.811	0.189
E25.8 Other adrenogenital disorders	0.000	0.811	0.189
M19.07 Primary arthrosis of other joints (Ankle and foot)	0.000	0.812	0.188
E31.9 Polyglandular dysfunction, unspecified	0.000	0.813	0.187
E31.8 Other polyglandular dysfunction	0.000	0.813	0.187
E31.1 Polyglandular hyperfunction	0.000	0.813	0.187
E20.0 Idiopathic hypoparathyroidism	0.000	0.815	0.185
M17.5 Other secondary gonarthrosis	0.000	0.819	0.181
E32.1 Abscess of thymus	0.000	0.819	0.181
E32.0 Persistent hyperplasia of thymus	0.000	0.819	0.181
E07.9 Disorder of thyroid, unspecified	0.000	0.819	0.181
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.000	0.819	0.181
E44 Protein-energy malnutrition of moderate and mild degree	0.000	0.820	0.180
E45 Retarded development following protein-energy malnutrition	0.000	0.820	0.180
E43 Unspecified severe protein-energy malnutrition	0.000	0.820	0.180
E42 Marasmic kwashiorkor	0.000	0.820	0.180
E41 Nutritional marasmus	0.000	0.820	0.180
E40 Kwashiorkor	0.000	0.820	0.180
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.820	0.180
E20.8 Other hypoparathyroidism	0.000	0.821	0.179
E27.4 Other and unspecified adrenocortical insufficiency	0.000	0.823	0.177
E31.0 Autoimmune polyglandular failure	0.000	0.824	0.176
E32.9 Disease of thymus, unspecified	0.000	0.825	0.175
E23.7 Disorder of pituitary gland, unspecified	0.000	0.826	0.174
E46 Unspecified protein-energy malnutrition	0.000	0.827	0.172
E20.1 Pseudohypoparathyroidism	0.000	0.829	0.171
E27.3 Drug-induced adrenocortical insufficiency	0.000	0.830	0.170
E32.8 Other diseases of thymus	0.000	0.832	0.168
E61 Deficiency of other nutrient elements	0.000	0.833	0.167
M17.3 Other posttraumatic gonarthrosis	0.000	0.833	0.167
M19.8 Other specified arthrosis	0.000	0.841	0.158
M17.2 Posttraumatic gonarthrosis, bilateral	0.000	0.844	0.156
E28 Ovarian dysfunction	0.000	0.845	0.155
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.845	0.155
E00 Congenital iodine-deficiency syndrome	0.000	0.845	0.155
E06.9 Thyroiditis, unspecified	0.000	0.846	0.154
E27.5 Adrenomedullary hyperfunction	0.000	0.846	0.154
E27.0 Other adrenocortical overactivity	0.000	0.846	0.154
M19.00 Primary arthrosis of other joints (Multiple sites)	0.000	0.846	0.154
M19.08 Primary arthrosis of other joints (Other)	0.000	0.848	0.152
E27.2 Addisonian crisis	0.000	0.850	0.150
E06.1 Subacute thyroiditis	0.000	0.851	0.149
E06.4 Drug-induced thyroiditis	0.000	0.853	0.147
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.000	0.853	0.147
E06.0 Acute thyroiditis	0.000	0.853	0.147
E61.1 Iron deficiency	0.000	0.855	0.145
E06.5 Other chronic thyroiditis	0.000	0.856	0.144
E54 Ascorbic acid deficiency	0.000	0.856	0.144
M15 Polyarthrosis	0.001	0.857	0.142
M19.2 Other secondary arthrosis	0.000	0.860	0.140
E64 Sequelae of malnutrition and other nutritional deficiencies	0.000	0.861	0.139
E50 Vitamin A deficiency	0.000	0.861	0.139
E60 Dietary zinc deficiency	0.000	0.861	0.139
E59 Dietary selenium deficiency	0.000	0.861	0.139
E52 Niacin deficiency [pellagra]	0.000	0.861	0.139
E07.1 Dyshormogenetic goitre	0.000	0.861	0.139
E07.0 Hypersecretion of calcitonin	0.000	0.861	0.139
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.000	0.862	0.138
M19.05 Primary arthrosis of other joints (Pelvic region and thigh)	0.000	0.862	0.138
M17.4 Other secondary gonarthrosis, bilateral	0.000	0.864	0.136
E63 Other nutritional deficiencies	0.000	0.866	0.134
M19.03 Primary arthrosis of other joints (Forearm)	0.000	0.866	0.134
M19.04 Primary arthrosis of other joints (Hand)	0.000	0.867	0.133
E56 Other vitamin deficiencies	0.000	0.869	0.131
E51 Thiamine deficiency	0.000	0.870	0.129
E44.1 Mild protein-energy malnutrition	0.000	0.871	0.129
E44.0 Moderate protein-energy malnutrition	0.000	0.871	0.129
E15 Nondiabetic hypoglycaemic coma	0.000	0.871	0.129
M20-M25 Other joint disorders	0.000	0.871	0.129
M16.0 Primary coxarthrosis, bilateral	0.000	0.872	0.128
E58 Dietary calcium deficiency	0.000	0.873	0.127
E61.2 Magnesium deficiency	0.000	0.874	0.126
M31 Other necrotising vasculopathies	0.000	0.875	0.125
E27.8 Other specified disorders of adrenal gland	0.000	0.876	0.124
E07.8 Other specified disorders of thyroid	0.000	0.876	0.124
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.876	0.124
M19.09 Primary arthrosis of other joints (Site unspecified)	0.000	0.877	0.123
E27.9 Disorder of adrenal gland, unspecified	0.000	0.878	0.122
M19.02 Primary arthrosis of other joints (Upper arm)	0.000	0.878	0.122
M19.84 Other specified arthrosis (Hand)	0.000	0.878	0.122
M19.1 Posttraumatic arthrosis of other joints	0.000	0.879	0.121
E61.9 Deficiency of nutrient element, unspecified	0.000	0.880	0.120
E61.8 Deficiency of other specified nutrient elements	0.000	0.880	0.120
E61.7 Deficiency of multiple nutrient elements	0.000	0.880	0.120
E61.6 Vanadium deficiency	0.000	0.880	0.120
E61.5 Molybdenum deficiency	0.000	0.880	0.120
E61.4 Chromium deficiency	0.000	0.880	0.120
E61.3 Manganese deficiency	0.000	0.880	0.120
E61.0 Copper deficiency	0.000	0.880	0.120
M31.3 Wegener's granulomatosis	0.000	0.883	0.117
M19.06 Primary arthrosis of other joints-Lower leg	0.000	0.884	0.116
M19.88 Other specified arthrosis (Other)	0.000	0.885	0.114
M19.86 Other specified arthrosis (Lower leg)	0.000	0.886	0.114
M19.85 Other specified arthrosis (Pelvic region and thigh)	0.000	0.886	0.114
M19.83 Other specified arthrosis (Forearm)	0.000	0.886	0.114
M19.82 Other specified arthrosis (Upper arm)	0.000	0.886	0.114
M19.81 Other specified arthrosis (Shoulder region)	0.000	0.886	0.114
M19.80 Other specified arthrosis (Multiple sites)	0.000	0.886	0.114
M19.87 Other specified arthrosis (Ankle and foot)	0.000	0.887	0.113
E53 Deficiency of other B group vitamins	0.000	0.888	0.112
E28.9 Ovarian dysfunction, unspecified	0.000	0.889	0.111
E28.8 Other ovarian dysfunction	0.000	0.889	0.111
E28.1 Androgen excess	0.000	0.889	0.111
E28.0 Oestrogen excess	0.000	0.889	0.111
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.000	0.889	0.111
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.000	0.889	0.111
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.000	0.889	0.111
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.000	0.889	0.111
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.889	0.111
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.000	0.889	0.111
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.000	0.889	0.111
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.000	0.889	0.111
M31.6 Other giant cell arteritis	0.000	0.890	0.110
E27.1 Primary adrenocortical insufficiency	0.000	0.890	0.110
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.000	0.891	0.109
M19.17 Post-traumatic arthrosis of other joints (Ankle and foot)	0.000	0.892	0.108
M21 Other acquired deformities of limbs	0.000	0.892	0.108
M19.89 Other specified arthrosis (Site unspecified)	0.000	0.894	0.106
M15.0 Primary generalised (osteo)arthrosis	0.001	0.894	0.105
E21.5 Disorder of parathyroid gland, unspecified	0.000	0.898	0.102
M21.1 Varus deformity, not elsewhere classified	0.000	0.898	0.102
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.000	0.899	0.101
E03 Other hypothyroidism	0.000	0.899	0.101
M19.29 Other secondary arthrosis (Site unspecified)	0.000	0.899	0.101
M19.28 Other secondary arthrosis (Other)	0.000	0.899	0.101
M19.26 Other secondary arthrosis of other joints-Lower leg	0.000	0.899	0.101
M19.25 Other secondary arthrosis (Pelvic region and thigh)	0.000	0.899	0.101
M19.24 Other secondary arthrosis (Hand)	0.000	0.899	0.101
M19.22 Other secondary arthrosis (Upper arm)	0.000	0.899	0.101
M19.20 Other secondary arthrosis (Multiple sites)	0.000	0.899	0.101
M33 Dermatopolymyositis	0.000	0.899	0.101
E21.4 Other specified disorders of parathyroid gland	0.000	0.899	0.100
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.000	0.899	0.100
E50.9 Vitamin A deficiency, unspecified	0.000	0.900	0.100
E50.8 Other manifestations of vitamin A deficiency	0.000	0.900	0.100
E50.7 Other ocular manifestations of vitamin A deficiency	0.000	0.900	0.100
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.000	0.900	0.100
E50.5 Vitamin A deficiency with night blindness	0.000	0.900	0.100
E50.4 Vitamin A deficiency with keratomalacia	0.000	0.900	0.100
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.000	0.900	0.100
E50.2 Vitamin A deficiency with corneal xerosis	0.000	0.900	0.100
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.000	0.900	0.100
E50.0 Vitamin A deficiency with conjunctival xerosis	0.000	0.900	0.100
E64.9 Sequelae of unspecified nutritional deficiency	0.000	0.900	0.100
E64.8 Sequelae of other nutritional deficiencies	0.000	0.900	0.100
E64.3 Sequelae of rickets	0.000	0.900	0.100
E64.2 Sequelae of vitamin C deficiency	0.000	0.900	0.100
E64.1 Sequelae of vitamin A deficiency	0.000	0.900	0.100
E64.0 Sequelae of protein-energy malnutrition	0.000	0.900	0.100
M15.9 Polyarthrosis, unspecified	0.001	0.902	0.097
M19.21 Other secondary arthrosis (Shoulder region)	0.000	0.903	0.097
M19.27 Other secondary arthrosis (Ankle and foot)	0.000	0.903	0.097
E63.8 Other specified nutritional deficiencies	0.000	0.903	0.096
E63.1 Imbalance of constituents of food intake	0.000	0.903	0.096
E63.0 Essential fatty acid [EFA] deficiency	0.000	0.903	0.096
M65-M68 Disorders of synovium and tendon	0.000	0.904	0.096
M31.0 Hypersensitivity angiitis	0.000	0.904	0.096
M15.8 Other polyarthrosis	0.001	0.904	0.095
E56.9 Vitamin deficiency, unspecified	0.000	0.906	0.094
E56.8 Deficiency of other vitamins	0.000	0.906	0.094
E56.0 Deficiency of vitamin E	0.000	0.906	0.094
M21.17 Varus deformity, not elsewhere classified (Ankle and foot)	0.000	0.906	0.094
M19.23 Other secondary arthrosis (Forearm)	0.000	0.906	0.093
E51.9 Thiamine deficiency, unspecified	0.000	0.907	0.093
E51.8 Other manifestations of thiamine deficiency	0.000	0.907	0.093
E51.1 Beriberi	0.000	0.907	0.093
M67 Other disorders of synovium and tendon	0.000	0.907	0.093
E63.9 Nutritional deficiency, unspecified	0.000	0.908	0.092
E55 Vitamin D deficiency	0.000	0.908	0.092
M21.0 Valgus deformity, not elsewhere classified	0.000	0.908	0.092
M67.1 Other contracture of tendon (sheath)	0.000	0.909	0.091
E53.9 Vitamin B deficiency, unspecified	0.000	0.909	0.091
M15.3 Secondary multiple arthrosis	0.001	0.910	0.089
M31.2 Lethal midline granuloma	0.000	0.910	0.090
M31.4 Aortic arch syndrome [Takayasu]	0.000	0.910	0.090
E28.3 Primary ovarian failure	0.001	0.911	0.089
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.000	0.911	0.089
M15.4 Erosive (osteo)arthrosis	0.001	0.911	0.088
M31.1 Thrombotic microangiopathy	0.000	0.912	0.088
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.000	0.913	0.087
M91-M94 Chondropathies	0.000	0.913	0.087
M19.19 Post-traumatic arthrosis of other joints (Site unspecified)	0.000	0.913	0.087
M19.18 Post-traumatic arthrosis of other joints (Other)	0.000	0.913	0.087
M19.15 Post-traumatic arthrosis of other joints (Pelvic region and thigh)	0.000	0.913	0.087
M19.10 Post-traumatic arthrosis of other joints (Multiple sites)	0.000	0.913	0.087
E56.1 Deficiency of vitamin K	0.000	0.914	0.086
M31.8 Other specified necrotising vasculopathies	0.000	0.914	0.086
M31.7 Microscopic polyangiitis	0.000	0.914	0.086
M33.1 Other dermatomyositis	0.000	0.914	0.086
M31.9 Necrotising vasculopathy, unspecified	0.000	0.915	0.085
E21.2 Other hyperparathyroidism	0.000	0.915	0.084
M15.1 Heberden's nodes (with arthropathy)	0.001	0.916	0.083
E51.2 Wernicke's encephalopathy	0.000	0.916	0.083
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.000	0.917	0.083
M32 Systemic lupus erythematosus	0.000	0.917	0.083
M21.16 Varus deformity, not elsewhere classified (Lower leg)	0.000	0.917	0.083
M21.7 Unequal limb length (acquired)	0.000	0.918	0.082
E21.0 Primary hyperparathyroidism	0.000	0.918	0.082
M19.14 Post-traumatic arthrosis of other joints (Hand)	0.000	0.919	0.081
M19.16 Post-traumatic arthrosis of other joints-Lower leg	0.000	0.919	0.080
M67.2 Synovial hypertrophy, not elsewhere classified	0.000	0.919	0.081
E53.1 Pyridoxine deficiency	0.000	0.920	0.080
E53.0 Riboflavin deficiency	0.000	0.920	0.080
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.000	0.920	0.080
M19.12 Post-traumatic arthrosis of other joints (Upper arm)	0.000	0.920	0.079
M15.00 Primary generalized (osteo)arthrosis, Multiple sites	0.001	0.922	0.078
M86-M90 Other osteopathies	0.000	0.923	0.077
M21.15 Varus deformity, not elsewhere classified (Pelvic region and thigh)	0.000	0.926	0.074
M21.6 Other acquired deformities of ankle and foot	0.000	0.926	0.073
M21.9 Acquired deformity of limb, unspecified	0.000	0.927	0.073
M21.19 Varus deformity, not elsewhere classified (Site unspecified)	0.000	0.927	0.073
M21.18 Varus deformity, not elsewhere classified (Other)	0.000	0.927	0.073
M21.14 Varus deformity, not elsewhere classified (Hand)	0.000	0.927	0.073
M21.13 Varus deformity, not elsewhere classified (Forearm)	0.000	0.927	0.073
M21.12 Varus deformity, not elsewhere classified (Upper arm)	0.000	0.927	0.073
M21.11 Varus deformity, not elsewhere classified (Shoulder region)	0.000	0.927	0.073
M21.10 Varus deformity, not elsewhere classified (Multiple sites)	0.000	0.927	0.073
M67.4 Ganglion	0.000	0.927	0.073
E03.5 Myxoedema coma	0.000	0.927	0.073
E03.4 Atrophy of thyroid (acquired)	0.000	0.927	0.073
E03.3 Postinfectious hypothyroidism	0.000	0.927	0.073
M33.9 Dermatopolymyositis, unspecified	0.000	0.928	0.072
M33.0 Juvenile dermatomyositis	0.000	0.928	0.072
M66 Spontaneous rupture of synovium and tendon	0.000	0.928	0.072
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.000	0.928	0.072
M22 Disorders of patella	0.000	0.929	0.071
M94 Other disorders of cartilage	0.000	0.929	0.071
E03.1 Congenital hypothyroidism without goitre	0.000	0.930	0.070
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.000	0.930	0.070
M67.0 Short Achilles tendon (acquired)	0.000	0.931	0.069
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.000	0.931	0.069
M92 Other juvenile osteochondrosis	0.000	0.932	0.068
M15.2 Bouchard's nodes (with arthropathy)	0.001	0.932	0.067
E03.8 Other specified hypothyroidism	0.000	0.932	0.068
M67.9 Disorder of synovium and tendon, unspecified	0.000	0.933	0.067
M67.3 Transient synovitis	0.000	0.933	0.067
M21.06 Valgus deformity, not elsewhere classified (Lower leg)	0.000	0.933	0.067
M32.8 Other forms of systemic lupus erythematosus	0.000	0.933	0.066
E03.0 Congenital hypothyroidism with diffuse goitre	0.000	0.934	0.066
M21.2 Flexion deformity	0.000	0.934	0.066
M89 Other disorders of bone	0.000	0.934	0.066
E55.0 Rickets, active	0.000	0.934	0.066
M21.09 Valgus deformity, not elsewhere classified (Site unspecified)	0.000	0.934	0.066
M21.08 Valgus deformity, not elsewhere classified (Other)	0.000	0.934	0.066
M21.05 Valgus deformity, not elsewhere classified (Pelvic region and thigh)	0.000	0.934	0.066
M21.04 Valgus deformity, not elsewhere classified (Hand)	0.000	0.934	0.066
M21.03 Valgus deformity, not elsewhere classified (Forearm)	0.000	0.934	0.066
M21.02 Valgus deformity, not elsewhere classified (Upper arm)	0.000	0.934	0.066
M21.01 Valgus deformity, not elsewhere classified (Shoulder region)	0.000	0.934	0.066
M21.00 Valgus deformity, not elsewhere classified (Multiple sites)	0.000	0.934	0.066
M60-M63 Disorders of muscles	0.000	0.934	0.066
M19.13 Post-traumatic arthrosis of other joints (Forearm)	0.001	0.934	0.065
M89.8 Other specified disorders of bone	0.000	0.934	0.066
M21.3 Wrist or foot drop (acquired)	0.000	0.935	0.065
M15.99 Polyosteoarthritis, unspecified	0.001	0.935	0.064
M00-M03 Infectious arthropathies	0.000	0.935	0.065
M21.57 Acquired clawhand, clubhand, clawfoot and clubfoot (Ankle and foot)	0.000	0.936	0.064
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.000	0.936	0.064
M36.3 Arthropathy in other blood disorders	0.000	0.936	0.064
M36.2 Haemophilic arthropathy	0.000	0.936	0.064
M36.1 Arthropathy in neoplastic disease	0.000	0.936	0.064
M36.0 Dermato(poly)myositis in neoplastic disease	0.000	0.936	0.064
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.936	0.064
M66.2 Spontaneous rupture of extensor tendons	0.000	0.936	0.064

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations