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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs4248166
log Bayes Factor = 75.4334
Chromosome 6   position 32,366,421  (GRCh37) Explore rs4248166 on Ensembl!
Variant rs4248166 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
C44.3 Skin of other and unspecified parts of face
1.000 0.000 0.000
J45.9 Asthma, unspecified
0.000 0.000 1.000
K51.9 Ulcerative colitis, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
C44 Other malignant neoplasms of skin
1.000 0.000 0.000
K51 Ulcerative colitis
1.000 0.000 0.000
E10.9 Without complications
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
K50.1 Crohn's disease of large intestine
1.000 0.000 0.000
K50 Crohn's disease [regional enteritis]
1.000 0.000 0.000
K50-K52 Noninfective enteritis and colitis
1.000 0.000 0.000
C44.7 Skin of lower limb, including hip
0.999 0.001 0.000
C44.2 Skin of ear and external auricular canal
0.995 0.005 0.000
C44.4 Skin of scalp and neck
0.994 0.006 0.000
E10.1 With ketoacidosis
0.000 0.007 0.993
K50.9 Crohn's disease, unspecified
0.981 0.019 0.000
E10.3 With ophthalmic complications
0.000 0.020 0.980
C44.5 Skin of trunk
0.978 0.022 0.000
K51.2 Ulcerative (chronic) proctitis
0.971 0.029 0.000
E10-E14 Diabetes mellitus
0.000 0.034 0.966
C44.6 Skin of upper limb, including shoulder
0.966 0.034 0.000
K51.4 Pseudopolyposis of colon
0.966 0.034 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.048 0.952
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.049 0.951
E16 Other disorders of pancreatic internal secretion
0.000 0.050 0.950
E16.2 Hypoglycaemia, unspecified
0.000 0.051 0.949
K51.8 Other ulcerative colitis
0.939 0.061 0.000
C44.0 Skin of lip
0.937 0.063 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.081 0.919
E27 Other disorders of adrenal gland
0.000 0.082 0.918
E27.1 Primary adrenocortical insufficiency
0.000 0.083 0.917
D86.9 Sarcoidosis, unspecified
0.000 0.094 0.906
Z93.2 Ileostomy status
0.902 0.098 0.000
C44.1 Skin of eyelid, including canthus
0.900 0.100 0.000
D86 Sarcoidosis
0.000 0.100 0.900
D86.0 Sarcoidosis of lung
0.000 0.119 0.881
D86.8 Sarcoidosis of other and combined sites
0.000 0.169 0.831
K51.5 Mucosal proctocolitis
0.807 0.193 0.000
E13 Other specified diabetes mellitus
0.000 0.202 0.798
D86.1 Sarcoidosis of lymph nodes
0.000 0.206 0.794
E22 Hyperfunction of pituitary gland
0.000 0.211 0.788
E10.4 With neurological complications
0.000 0.218 0.782
E10.8 With unspecified complications
0.000 0.221 0.779
E00-E07 Disorders of thyroid gland
0.000 0.223 0.777
E16.1 Other hypoglycaemia
0.000 0.230 0.770
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.234 0.766
E03 Other hypothyroidism
0.000 0.238 0.762
E10.6 With other specified complications
0.000 0.241 0.759
E10.2 With renal complications
0.000 0.243 0.757
E27.2 Addisonian crisis
0.000 0.244 0.756
E10.0 With coma
0.000 0.246 0.754
E03.9 Hypothyroidism, unspecified
0.000 0.251 0.749
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.259 0.741
K90 Intestinal malabsorption
0.000 0.270 0.730
C44.9 Malignant neoplasm of skin, unspecified
0.728 0.272 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.276 0.724
K50.8 Other Crohn's disease
0.719 0.281 0.000
C44.8 Overlapping lesion of skin
0.717 0.283 0.000
E10.7 With multiple complications
0.000 0.283 0.717
K52 Other non-infective gastro-enteritis and colitis
0.710 0.290 0.000
E12 Malnutrition-related diabetes mellitus
0.000 0.307 0.693
E24 Cushing's syndrome
0.000 0.307 0.693
E15 Nondiabetic hypoglycaemic coma
0.000 0.318 0.681
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.319 0.681
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.319 0.681
E16.4 Abnormal secretion of gastrin
0.000 0.319 0.681
E16.3 Increased secretion of glucagon
0.000 0.319 0.681
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.321 0.679
E13.9 Without complications
0.000 0.322 0.678
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.337 0.663
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.341 0.659
E32 Diseases of thymus
0.000 0.341 0.659
E31 Polyglandular dysfunction
0.000 0.341 0.659
E30 Disorders of puberty, not elsewhere classified
0.000 0.341 0.659
E25 Adrenogenital disorders
0.000 0.341 0.659
E20 Hypoparathyroidism
0.000 0.341 0.658
E27.5 Adrenomedullary hyperfunction
0.000 0.342 0.658
E27.0 Other adrenocortical overactivity
0.000 0.342 0.658
D86.3 Sarcoidosis of skin
0.000 0.355 0.645
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.355 0.645
K51.0 Ulcerative (chronic) enterocolitis
0.643 0.356 0.000
E40-E46 Malnutrition
0.000 0.368 0.632
K52.1 Toxic gastro-enteritis and colitis
0.620 0.380 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.380 0.620
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.383 0.617
E14 Unspecified diabetes mellitus
0.000 0.388 0.612
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.392 0.608
K51.1 Ulcerative (chronic) ileocolitis
0.608 0.392 0.000
K51.3 Ulcerative (chronic) rectosigmoiditis
0.607 0.393 0.000
E10.5 With peripheral circulatory complications
0.000 0.412 0.588
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.423 0.577
K52.3 Indeterminate colitis
0.574 0.426 0.000
E13.8 With unspecified complications
0.000 0.427 0.572
E13.7 With multiple complications
0.000 0.427 0.572
E13.6 With other specified complications
0.000 0.427 0.572
E13.5 With peripheral circulatory complications
0.000 0.427 0.572
E13.4 With neurological complications
0.000 0.427 0.572
E13.3 With ophthalmic complications
0.000 0.427 0.572
E13.2 With renal complications
0.000 0.427 0.572
E13.1 With ketoacidosis
0.000 0.427 0.572
E13.0 With coma
0.000 0.427 0.572
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.435 0.565
E22.8 Other hyperfunction of pituitary gland
0.000 0.435 0.565
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.443 0.557
E00 Congenital iodine-deficiency syndrome
0.000 0.443 0.557
E65-E68 Obesity and other hyperalimentation
0.000 0.447 0.553
K90.8 Other intestinal malabsorption
0.000 0.449 0.551
E34 Other endocrine disorders
0.000 0.451 0.549
E22.0 Acromegaly and pituitary gigantism
0.000 0.452 0.548
E03.5 Myxoedema coma
0.000 0.453 0.546
E03.4 Atrophy of thyroid (acquired)
0.000 0.453 0.546
E03.3 Postinfectious hypothyroidism
0.000 0.453 0.546
E03.1 Congenital hypothyroidism without goitre
0.000 0.453 0.546
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.453 0.546
E29 Testicular dysfunction
0.000 0.454 0.546
E27.8 Other specified disorders of adrenal gland
0.000 0.455 0.545
E24.9 Cushing's syndrome, unspecified
0.000 0.469 0.530
E03.8 Other specified hypothyroidism
0.000 0.474 0.526
K90.3 Pancreatic steatorrhoea
0.000 0.476 0.523
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.476 0.523
K90.1 Tropical sprue
0.000 0.476 0.523
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.476 0.523
K90.9 Intestinal malabsorption, unspecified
0.000 0.483 0.517
E12.9 Without complications
0.000 0.503 0.497
E12.8 With unspecified complications
0.000 0.503 0.497
E12.7 With multiple complications
0.000 0.503 0.497
E12.6 With other specified complications
0.000 0.503 0.497
E12.5 With peripheral circulatory complications
0.000 0.503 0.497
E12.4 With neurological complications
0.000 0.503 0.497
E12.3 With ophthalmic complications
0.000 0.503 0.497
E12.2 With renal complications
0.000 0.503 0.497
E12.1 With ketoacidosis
0.000 0.503 0.497
E12.0 With coma
0.000 0.503 0.497
E24.8 Other Cushing's syndrome
0.000 0.503 0.497
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.503 0.497
E24.3 Ectopic ACTH syndrome
0.000 0.503 0.497
E24.2 Drug-induced Cushing's syndrome
0.000 0.503 0.497
E24.1 Nelson's syndrome
0.000 0.503 0.497
E24.0 Pituitary-dependent Cushing's disease
0.000 0.503 0.497
K52.2 Allergic and dietetic gastro-enteritis and colitis
0.497 0.503 0.000
E21.0 Primary hyperparathyroidism
0.000 0.507 0.492
E27.9 Disorder of adrenal gland, unspecified
0.000 0.508 0.492
E22.1 Hyperprolactinaemia
0.000 0.514 0.486
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.516 0.484
J45 Asthma
0.000 0.519 0.481
E25.9 Adrenogenital disorder, unspecified
0.000 0.527 0.473
E25.8 Other adrenogenital disorders
0.000 0.527 0.473
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.527 0.473
E30.9 Disorder of puberty, unspecified
0.000 0.527 0.473
E30.8 Other disorders of puberty
0.000 0.527 0.473
E30.1 Precocious puberty
0.000 0.527 0.473
E30.0 Delayed puberty
0.000 0.527 0.473
E31.9 Polyglandular dysfunction, unspecified
0.000 0.527 0.473
E31.8 Other polyglandular dysfunction
0.000 0.527 0.473
E31.1 Polyglandular hyperfunction
0.000 0.527 0.473
E31.0 Autoimmune polyglandular failure
0.000 0.527 0.473
E32.9 Disease of thymus, unspecified
0.000 0.527 0.473
E32.8 Other diseases of thymus
0.000 0.527 0.473
E32.1 Abscess of thymus
0.000 0.527 0.473
E32.0 Persistent hyperplasia of thymus
0.000 0.527 0.473
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.527 0.473
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.527 0.473
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.527 0.473
E20.8 Other hypoparathyroidism
0.000 0.528 0.472
E20.1 Pseudohypoparathyroidism
0.000 0.528 0.472
E20.0 Idiopathic hypoparathyroidism
0.000 0.528 0.472
E20.9 Hypoparathyroidism, unspecified
0.000 0.528 0.471
E14.3 With ophthalmic complications
0.000 0.537 0.463
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.547 0.453
E45 Retarded development following protein-energy malnutrition
0.000 0.547 0.453
E43 Unspecified severe protein-energy malnutrition
0.000 0.547 0.453
E42 Marasmic kwashiorkor
0.000 0.547 0.453
E41 Nutritional marasmus
0.000 0.547 0.453
E40 Kwashiorkor
0.000 0.547 0.453
K52.8 Other specified non-infective gastro-enteritis and colitis
0.453 0.547 0.000
E28 Ovarian dysfunction
0.000 0.554 0.445
E05.5 Thyroid crisis or storm
0.000 0.556 0.444
E05.4 Thyrotoxicosis factitia
0.000 0.556 0.444
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.556 0.444
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.556 0.444
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.557 0.442
E21.4 Other specified disorders of parathyroid gland
0.000 0.557 0.442
E21.2 Other hyperparathyroidism
0.000 0.557 0.442
E14.8 With unspecified complications
0.000 0.561 0.439
E14.7 With multiple complications
0.000 0.561 0.439
E14.2 Withrenal complications
0.000 0.561 0.439
E14.1 With ketoacidosis
0.000 0.561 0.439
E14.0 With coma
0.000 0.561 0.439
E14.6 With other specified complications
0.000 0.564 0.435
E14.9 Without complications
0.000 0.569 0.431
K52.0 Gastro-enteritis and colitis due to radiation
0.430 0.570 0.000
E06 Thyroiditis
0.000 0.575 0.424
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.577 0.423
E34.0 Carcinoid syndrome
0.000 0.591 0.409
E46 Unspecified protein-energy malnutrition
0.000 0.597 0.402
E66 Obesity
0.000 0.598 0.402
E23 Hypofunction and other disorders of pituitary gland
0.000 0.599 0.401
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.600 0.399
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.600 0.399
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.600 0.399
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.600 0.399
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.600 0.399
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.600 0.399
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.600 0.399
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.600 0.399
E11 Non-insulin-dependent diabetes mellitus
0.000 0.600 0.400
E67 Other hyperalimentation
0.000 0.603 0.396
E68 Sequelae of hyperalimentation
0.000 0.603 0.396
E14.5 With peripheral circulatory complications
0.000 0.605 0.395
E34.5 Androgen resistance syndrome
0.000 0.606 0.394
E34.4 Constitutional tall stature
0.000 0.606 0.394
E34.3 Short stature, not elsewhere classified
0.000 0.606 0.394
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.606 0.394
E34.1 Other hypersecretion of intestinal hormones
0.000 0.606 0.394
E26 Hyperaldosteronism
0.001 0.607 0.391
E29.9 Testicular dysfunction, unspecified
0.000 0.609 0.391
E29.8 Other testicular dysfunction
0.000 0.609 0.391
E29.0 Testicular hyperfunction
0.000 0.609 0.391
E14.4 With neurological complications
0.000 0.611 0.389
E05.8 Other thyrotoxicosis
0.000 0.611 0.389
E11.1 With ketoacidosis
0.000 0.626 0.374
D80-D89 Certain disorders involving the immune mechanism
0.000 0.628 0.372
J45.0 Predominantly allergic asthma
0.000 0.630 0.370
E07 Other disorders of thyroid
0.000 0.642 0.358
J45.8 Mixed asthma
0.000 0.655 0.345
J45.1 Nonallergic asthma
0.000 0.655 0.345
K52.9 Non-infective gastro-enteritis and colitis, unspecified
0.342 0.658 0.000
E34.8 Other specified endocrine disorders
0.000 0.664 0.336
E34.9 Endocrine disorder, unspecified
0.000 0.664 0.335
E44.1 Mild protein-energy malnutrition
0.000 0.675 0.325
E44.0 Moderate protein-energy malnutrition
0.000 0.675 0.325
E50-E64 Other nutritional deficiencies
0.000 0.679 0.321
E28.9 Ovarian dysfunction, unspecified
0.000 0.680 0.319
E28.8 Other ovarian dysfunction
0.000 0.680 0.319
E28.1 Androgen excess
0.000 0.680 0.319
E28.0 Oestrogen excess
0.000 0.680 0.319
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.683 0.317
E11.2 With renal complications
0.000 0.687 0.313
E66.9 Obesity, unspecified
0.000 0.689 0.311
C43-C44 Melanoma and other malignant neoplasms of skin
0.310 0.690 0.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.691 0.309
D51 Vitamin B12 deficiency anaemia
0.000 0.695 0.305
E06.5 Other chronic thyroiditis
0.000 0.695 0.304
E06.4 Drug-induced thyroiditis
0.000 0.695 0.304
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.695 0.304
E06.1 Subacute thyroiditis
0.000 0.695 0.304
E06.0 Acute thyroiditis
0.000 0.695 0.304
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.696 0.304
E23.6 Other disorders of pituitary gland
0.000 0.697 0.302
D50-D53 Nutritional anaemias
0.000 0.699 0.301
E06.9 Thyroiditis, unspecified
0.000 0.709 0.291
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.711 0.289
E66.1 Drug-induced obesity
0.000 0.711 0.288
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.712 0.287
E23.1 Drug-induced hypopituitarism
0.000 0.712 0.287
E11.7 With multiple complications
0.000 0.713 0.287
E67.8 Other specified hyperalimentation
0.000 0.715 0.284
E67.3 Hypervitaminosis D
0.000 0.715 0.284
E67.2 Megavitamin-B6 syndrome
0.000 0.715 0.284
E67.1 Hypercarotenaemia
0.000 0.715 0.284
E67.0 Hypervitaminosis A
0.000 0.715 0.284
E66.8 Other obesity
0.000 0.718 0.282
E26.8 Other hyperaldosteronism
0.001 0.718 0.280
E26.1 Secondary hyperaldosteronism
0.001 0.718 0.280
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.721 0.279
E29.1 Testicular hypofunction
0.000 0.722 0.278
D50 Iron deficiency anaemia
0.000 0.723 0.277
D50.9 Iron deficiency anaemia, unspecified
0.000 0.723 0.277
E23.7 Disorder of pituitary gland, unspecified
0.000 0.724 0.276
E11.6 With other specified complications
0.000 0.725 0.275
K50.0 Crohn's disease of small intestine
0.275 0.725 0.000
D82 Immunodeficiency associated with other major defects
0.000 0.733 0.267
D81 Combined immunodeficiencies
0.000 0.733 0.267
E11.8 With unspecified complications
0.000 0.733 0.266
E28.3 Primary ovarian failure
0.000 0.736 0.264
E07.1 Dyshormogenetic goitre
0.000 0.743 0.256
E07.0 Hypersecretion of calcitonin
0.000 0.743 0.256
E65 Localised adiposity
0.001 0.744 0.256
E11.0 With coma
0.000 0.749 0.251
E07.8 Other specified disorders of thyroid
0.000 0.756 0.243
D83 Common variable immunodeficiency
0.000 0.761 0.239
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.235 0.765 0.000
E23.2 Diabetes insipidus
0.000 0.765 0.235
E66.0 Obesity due to excess calories
0.000 0.767 0.233
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.769 0.230
E63 Other nutritional deficiencies
0.000 0.769 0.230
E56 Other vitamin deficiencies
0.000 0.769 0.230
E50 Vitamin A deficiency
0.000 0.769 0.230
E60 Dietary zinc deficiency
0.000 0.769 0.230
E59 Dietary selenium deficiency
0.000 0.769 0.230
E54 Ascorbic acid deficiency
0.000 0.769 0.230
E52 Niacin deficiency [pellagra]
0.000 0.769 0.230
D80 Immunodeficiency with predominantly antibody defects
0.000 0.775 0.225
E11.5 With peripheral circulatory complications
0.000 0.776 0.224
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.781 0.219
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.781 0.219
D51.2 Transcobalamin II deficiency
0.000 0.781 0.219
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.781 0.219
E26.9 Hyperaldosteronism, unspecified
0.002 0.781 0.217
E21.3 Hyperparathyroidism, unspecified
0.000 0.781 0.219
E58 Dietary calcium deficiency
0.000 0.782 0.217
D52 Folate deficiency anaemia
0.000 0.787 0.213
D84 Other immunodeficiencies
0.001 0.787 0.212
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.212 0.788 0.000
E51 Thiamine deficiency
0.000 0.789 0.210
E28.2 Polycystic ovarian syndrome
0.000 0.790 0.209
M45.X9 Ankylosing spondylitis (Site unspecified)
0.208 0.792 0.000
D53 Other nutritional anaemias
0.000 0.794 0.206
E53 Deficiency of other B group vitamins
0.000 0.798 0.202
E11.3 With ophthalmic complications
0.000 0.800 0.200
D50.1 Sideropenic dysphagia
0.000 0.801 0.199
E06.3 Autoimmune thyroiditis
0.000 0.802 0.198
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.805 0.194
E11.4 With neurological complications
0.000 0.808 0.192
D81.9 Combined immunodeficiency, unspecified
0.000 0.808 0.191
D81.8 Other combined immunodeficiencies
0.000 0.808 0.191
D81.7 Major histocompatibility complex class II deficiency
0.000 0.808 0.191
D81.6 Major histocompatibility complex class I deficiency
0.000 0.808 0.191
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.808 0.191
D81.4 Nezelof's syndrome
0.000 0.808 0.191
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.808 0.191
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.808 0.191
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.808 0.191
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.808 0.191
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.808 0.191
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.808 0.191
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.808 0.191
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.808 0.191
D82.2 Immunodeficiency with short-limbed stature
0.000 0.808 0.191
D82.1 Di George's syndrome
0.000 0.808 0.191
D82.0 Wiskott-Aldrich syndrome
0.000 0.808 0.191
Z93 Artificial opening status
0.192 0.808 0.000
D55-D59 Haemolytic anaemias
0.000 0.810 0.189
E61 Deficiency of other nutrient elements
0.000 0.816 0.184
C82.0 Small cleaved cell, follicular
0.184 0.816 0.000
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.173 0.827 0.000
D83.8 Other common variable immunodeficiencies
0.000 0.828 0.171
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.828 0.171
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.828 0.171
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.828 0.171
C82.3 Follicular lymphoma grade IIIa
0.167 0.833 0.000
E50.9 Vitamin A deficiency, unspecified
0.000 0.834 0.165
E50.8 Other manifestations of vitamin A deficiency
0.000 0.834 0.165
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.834 0.165
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.834 0.165
E50.5 Vitamin A deficiency with night blindness
0.000 0.834 0.165
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.834 0.165
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.834 0.165
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.834 0.165
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.834 0.165
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.834 0.165
E56.9 Vitamin deficiency, unspecified
0.000 0.834 0.165
E56.8 Deficiency of other vitamins
0.000 0.834 0.165
E56.1 Deficiency of vitamin K
0.000 0.834 0.165
E56.0 Deficiency of vitamin E
0.000 0.834 0.165
E63.9 Nutritional deficiency, unspecified
0.000 0.834 0.165
E63.8 Other specified nutritional deficiencies
0.000 0.834 0.165
E63.1 Imbalance of constituents of food intake
0.000 0.834 0.165
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.834 0.165
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.834 0.165
E64.8 Sequelae of other nutritional deficiencies
0.000 0.834 0.165
E64.3 Sequelae of rickets
0.000 0.834 0.165
E64.2 Sequelae of vitamin C deficiency
0.000 0.834 0.165
E64.1 Sequelae of vitamin A deficiency
0.000 0.834 0.165
E64.0 Sequelae of protein-energy malnutrition
0.000 0.834 0.165
Z93.8 Other artificial opening status
0.164 0.836 0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.838 0.161
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.838 0.161
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.838 0.161
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.838 0.161
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.838 0.161
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.838 0.161
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.838 0.161
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.839 0.160
C82.2 Large cell, follicular
0.158 0.842 0.000
E55 Vitamin D deficiency
0.001 0.843 0.156
D52.8 Other folate deficiency anaemias
0.000 0.847 0.153
D52.1 Drug-induced folate deficiency anaemia
0.000 0.847 0.153
D52.0 Dietary folate deficiency anaemia
0.000 0.847 0.153
D59 Acquired haemolytic anaemia
0.000 0.847 0.153
D84.8 Other specified immunodeficiencies
0.001 0.847 0.152
D84.1 Defects in the complement system
0.001 0.847 0.152
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.001 0.847 0.152
M45 Ankylosing spondylitis
0.152 0.848 0.000
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.848 0.152
C82.6 Cutaneous follicle centre lymphoma
0.152 0.848 0.000
C82.5 Diffuse follicle centre lymphoma
0.152 0.848 0.000
C82.4 Follicular lymphoma grade IIIb
0.152 0.848 0.000
E26.0 Primary hyperaldosteronism
0.002 0.848 0.150
E51.9 Thiamine deficiency, unspecified
0.000 0.849 0.151
E51.8 Other manifestations of thiamine deficiency
0.000 0.849 0.151
E51.1 Beriberi
0.000 0.849 0.151
D52.9 Folate deficiency anaemia, unspecified
0.000 0.849 0.150
C43 Malignant melanoma of skin
0.150 0.850 0.000
Z93.6 Other artificial openings of urinary tract status
0.148 0.852 0.000
D53.8 Other specified nutritional anaemias
0.000 0.852 0.148
D53.2 Scorbutic anaemia
0.000 0.852 0.148
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.852 0.148
D53.0 Protein deficiency anaemia
0.000 0.852 0.148
C82.1 Mixed small cleaved and large cell, follicular
0.146 0.854 0.000
E53.1 Pyridoxine deficiency
0.000 0.855 0.145
E53.0 Riboflavin deficiency
0.000 0.855 0.145
L90.0 Lichen sclerosus et atrophicus
0.000 0.855 0.145
D83.9 Common variable immunodeficiency, unspecified
0.001 0.856 0.143
Z93.9 Artificial opening status, unspecified
0.142 0.858 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.860 0.139
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.860 0.139
D89.3 Immune reconstitution syndrome
0.000 0.860 0.139
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.860 0.139
E61.2 Magnesium deficiency
0.000 0.861 0.139
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.138 0.862 0.000
D53.9 Nutritional anaemia, unspecified
0.000 0.862 0.137
D57 Sickle-cell disorders
0.000 0.864 0.136
D55 Anaemia due to enzyme disorders
0.000 0.864 0.136
E23.0 Hypopituitarism
0.001 0.865 0.134
M45.X2 Ankylosing spondylitis (Cervical region)
0.135 0.865 0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.866 0.133
E53.8 Deficiency of other specified B group vitamins
0.000 0.866 0.134
C83 Diffuse non-Hodgkin's lymphoma
0.133 0.867 0.000
C83.3 Large cell (diffuse)
0.133 0.867 0.000
E61.9 Deficiency of nutrient element, unspecified
0.000 0.868 0.132
E61.8 Deficiency of other specified nutrient elements
0.000 0.868 0.132
E61.7 Deficiency of multiple nutrient elements
0.000 0.868 0.132
E61.6 Vanadium deficiency
0.000 0.868 0.132
E61.5 Molybdenum deficiency
0.000 0.868 0.132
E61.4 Chromium deficiency
0.000 0.868 0.132
E61.3 Manganese deficiency
0.000 0.868 0.132
E61.0 Copper deficiency
0.000 0.868 0.132
C43.6 Malignant melanoma of upper limb, including shoulder
0.132 0.868 0.000
E51.2 Wernicke's encephalopathy
0.001 0.868 0.131
E53.9 Vitamin B deficiency, unspecified
0.000 0.869 0.131
E11.9 Without complications
0.000 0.870 0.130
Z93.4 Other artificial openings of gastro-intestinal tract status
0.130 0.870 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.127 0.873 0.000
D89.1 Cryoglobulinaemia
0.000 0.874 0.125
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.125 0.875 0.000
D59.1 Other autoimmune haemolytic anaemias
0.000 0.876 0.124
Z93.1 Gastrostomy status
0.124 0.876 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.122 0.878 0.000
C43.4 Malignant melanoma of scalp and neck
0.121 0.879 0.000
D56 Thalassaemia
0.000 0.882 0.118
Z93.0 Tracheostomy status
0.118 0.882 0.000
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.886 0.114
E55.0 Rickets, active
0.001 0.887 0.112
C83.1 Small cleaved cell (diffuse)
0.112 0.888 0.000
D58 Other hereditary haemolytic anaemias
0.000 0.888 0.112
D59.8 Other acquired haemolytic anaemias
0.000 0.890 0.110
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.890 0.110
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.890 0.110
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.890 0.110
D59.3 Haemolytic-uraemic syndrome
0.000 0.890 0.110
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.890 0.110
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.890 0.110
C83.2 Mixed small and large cell (diffuse)
0.110 0.890 0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.109 0.891 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.109 0.891 0.000
M45.X6 Ankylosing spondylitis (Lumbar region)
0.109 0.891 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.109 0.891 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.109 0.891 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.109 0.891 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.109 0.891 0.000
L90 Atrophic disorders of skin
0.000 0.891 0.109
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.892 0.108
C43.8 Overlapping malignant melanoma of skin
0.108 0.892 0.000
C43.1 Malignant melanoma of eyelid, including canthus
0.108 0.892 0.000
C43.0 Malignant melanoma of lip
0.108 0.892 0.000
C95 Leukaemia of unspecified cell type
0.105 0.894 0.000
C43.2 Malignant melanoma of ear and external auricular canal
0.103 0.897 0.000
C43.7 Malignant melanoma of lower limb, including hip
0.103 0.897 0.000
D60-D64 Aplastic and other anaemias
0.000 0.898 0.102
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.099 0.901 0.000
C94 Other leukaemias of specified cell type
0.099 0.901 0.000
C93 Monocytic leukaemia
0.099 0.901 0.000
C86 Other specified types of T/NK-cell lymphoma
0.099 0.901 0.000
D84.9 Immunodeficiency, unspecified
0.001 0.902 0.098
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.902 0.098
D55.8 Other anaemias due to enzyme disorders
0.000 0.902 0.098
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.902 0.098
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.902 0.098
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.902 0.098
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.902 0.098
D57.8 Other sickle-cell disorders
0.000 0.902 0.098
D57.3 Sickle-cell trait
0.000 0.902 0.098
D57.2 Double heterozygous sickling disorders
0.000 0.902 0.098
D57.1 Sickle-cell anaemia without crisis
0.000 0.902 0.098
D57.0 Sickle-cell anaemia with crisis
0.000 0.902 0.098
C83.6 Undifferentiated (diffuse)
0.096 0.904 0.000
C83.5 Lymphoblastic (diffuse)
0.096 0.904 0.000
C83.4 Immunoblastic (diffuse)
0.096 0.904 0.000
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.095 0.905 0.000
L90.5 Scar conditions and fibrosis of skin
0.000 0.906 0.094
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.907 0.093
E07.9 Disorder of thyroid, unspecified
0.001 0.908 0.091
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.091 0.909 0.000
C85.0 Lymphosarcoma
0.091 0.909 0.000
Z93.5 Cystostomy status
0.091 0.909 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.089 0.911 0.000
C81 Hodgkin's disease
0.089 0.911 0.000
Z93.3 Colostomy status
0.089 0.911 0.000
C83.7 Burkitt's tumour
0.088 0.912 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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