TreeWAS – Variant ID: rs4457591

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
F05.9 Delirium, unspecified	0.000	0.943	0.057
F05 Delirium, not induced by alcohol and other psychoactive substances	0.000	0.961	0.039
F05.8 Other delirium	0.000	0.967	0.033
F05.1 Delirium superimposed on dementia	0.000	0.969	0.031
F05.0 Delirium not superimposed on dementia, so described	0.000	0.971	0.029
C18.2 Ascending colon	0.021	0.979	0.000
L28.0 Lichen simplex chronicus	0.019	0.981	0.000
S22.30 Fracture of rib (closed)	0.000	0.985	0.015
H66.9 Otitis media, unspecified	0.014	0.986	0.000
H66 Suppurative and unspecified otitis media	0.010	0.990	0.000
H72.9 Perforation of tympanic membrane, unspecified	0.009	0.991	0.000
N99.4 Postprocedural pelvic peritoneal adhesions	0.009	0.991	0.000
T86.8 Failure and rejection of other transplanted organs and tissues	0.009	0.991	0.000
I69.3 Sequelae of cerebral infarction	0.000	0.991	0.009
H72 Perforation of tympanic membrane	0.009	0.991	0.000
Y84.8 Other medical procedures	0.000	0.991	0.009
H66.0 Acute suppurative otitis media	0.008	0.992	0.000
H66.3 Other chronic suppurative otitis media	0.008	0.992	0.000
F00-F09 Organic, including symptomatic, mental disorders	0.000	0.992	0.008
H66.2 Chronic atticoantral suppurative otitis media	0.008	0.992	0.000
H65-H75 Diseases of middle ear and mastoid	0.008	0.992	0.000
H66.4 Suppurative otitis media, unspecified	0.007	0.993	0.000
E27.1 Primary adrenocortical insufficiency	0.000	0.993	0.007
S22.3 Fracture of rib	0.000	0.993	0.007
H72.2 Other marginal perforations of tympanic membrane	0.007	0.993	0.000
E27.4 Other and unspecified adrenocortical insufficiency	0.000	0.993	0.007
H72.1 Attic perforation of tympanic membrane	0.007	0.993	0.000
H71 Cholesteatoma of middle ear	0.007	0.993	0.000
O41.0 Oligohydramnios	0.000	0.993	0.007
F02 Dementia in other diseases classified elsewhere	0.000	0.993	0.007
C79.3 Secondary malignant neoplasm of brain and cerebral meninges	0.000	0.993	0.007
E27 Other disorders of adrenal gland	0.000	0.993	0.007
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction	0.000	0.993	0.007
H66.1 Chronic tubotympanic suppurative otitis media	0.006	0.993	0.000
H72.0 Central perforation of tympanic membrane	0.006	0.994	0.000
I69 Sequelae of cerebrovascular disease	0.000	0.994	0.006
F02.3 Dementia in Parkinson's disease	0.000	0.994	0.006
N31.9 Neuromuscular dysfunction of bladder, unspecified	0.000	0.994	0.006
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances	0.000	0.994	0.006
M23.21 Derangement of meniscus due to old tear or injury (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.000	0.994	0.006
L28 Lichen simplex chronicus and prurigo	0.006	0.994	0.000
F09 Unspecified organic or symptomatic mental disorder	0.000	0.994	0.006
I69.0 Sequelae of subarachnoid haemorrhage	0.000	0.994	0.006
H73 Other disorders of tympanic membrane	0.006	0.994	0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction	0.000	0.994	0.006
C79.7 Secondary malignant neoplasm of adrenal gland	0.000	0.994	0.006
E27.2 Addisonian crisis	0.000	0.994	0.006
E27.8 Other specified disorders of adrenal gland	0.000	0.994	0.006
E27.3 Drug-induced adrenocortical insufficiency	0.000	0.994	0.006
H68 Eustachian salpingitis and obstruction	0.006	0.994	0.000
F07.2 Postconcussional syndrome	0.000	0.994	0.006
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere	0.006	0.994	0.000
H67 Otitis media in diseases classified elsewhere	0.006	0.994	0.000
S22.31 Fracture of rib (open)	0.000	0.994	0.005
F06 Other mental disorders due to brain damage and dysfunction and to physical disease	0.000	0.994	0.006
F01 Vascular dementia	0.000	0.994	0.005
Y79.2 Prosthetic and other implants, materials and accessory devices	0.005	0.995	0.000
F07.0 Organic personality disorder	0.000	0.995	0.005
F02.8 Dementia in other specified diseases classified elsewhere	0.000	0.995	0.005
F02.4 Dementia in human immunodeficiency virus [HIV] disease	0.000	0.995	0.005
F02.2 Dementia in Huntington's disease	0.000	0.995	0.005
F02.1 Dementia in Creutzfeldt-Jakob disease	0.000	0.995	0.005
F02.0 Dementia in Pick's disease	0.000	0.995	0.005
C79 Secondary malignant neoplasm of other sites	0.000	0.995	0.005
E27.5 Adrenomedullary hyperfunction	0.000	0.995	0.005
E27.0 Other adrenocortical overactivity	0.000	0.995	0.005
N81.3 Complete uterovaginal prolapse	0.000	0.995	0.005
H65 Nonsuppurative otitis media	0.005	0.995	0.000
C79.9 Secondary malignant neoplasm, unspecified site	0.000	0.995	0.005
O41 Other disorders of amniotic fluid and membranes	0.000	0.995	0.005
I69.8 Sequelae of other and unspecified cerebrovascular diseases	0.000	0.995	0.005
M84.12 Nonunion of fracture [pseudarthrosis] (Upper arm)	0.000	0.995	0.005
H65.4 Other chronic nonsuppurative otitis media	0.005	0.995	0.000
F07.8 Other organic personality and behavioural disorders due to brain disease, damage and dysfunction	0.000	0.995	0.005
F07.1 Postencephalitic syndrome	0.000	0.995	0.005
H73.8 Other specified disorders of tympanic membrane	0.005	0.995	0.000
M07.30 Other psoriatic arthropathies (Multiple sites)	0.000	0.995	0.005
H72.8 Other perforations of tympanic membrane	0.005	0.995	0.000
S92.20 Fracture of other tarsal bone(s) (closed)	0.005	0.995	0.000
H73.0 Acute myringitis	0.005	0.995	0.000
F06.9 Unspecified mental disorder due to brain damage and dysfunction and to physical disease	0.000	0.995	0.005
O41.8 Other specified disorders of amniotic fluid and membranes	0.000	0.995	0.005
F03 Unspecified dementia	0.000	0.995	0.005
C79.2 Secondary malignant neoplasm of skin	0.000	0.995	0.005
O41.1 Infection of amniotic sac and membranes	0.000	0.995	0.005
N30.1 Interstitial cystitis (chronic)	0.000	0.995	0.005
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system	0.000	0.995	0.004
H73.1 Chronic myringitis	0.004	0.995	0.000
H68.1 Obstruction of Eustachian tube	0.004	0.996	0.000
L28.2 Other prurigo	0.004	0.996	0.000
E27.9 Disorder of adrenal gland, unspecified	0.000	0.996	0.004
H68.0 Eustachian salpingitis	0.004	0.996	0.000
F07.9 Unspecified organic personality and behavioural disorder due to brain disease, damage and dysfunction	0.000	0.996	0.004
H65.3 Chronic mucoid otitis media	0.004	0.996	0.000
H69 Other disorders of Eustachian tube	0.004	0.996	0.000
H67.8 Otitis media in other diseases classified elsewhere	0.004	0.996	0.000
H67.1 Otitis media in viral diseases classified elsewhere	0.004	0.996	0.000
H67.0 Otitis media in bacterial diseases classified elsewhere	0.004	0.996	0.000
H75.8 Other specified disorders of middle ear and mastoid in diseases classified elsewhere	0.004	0.996	0.000
H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere	0.004	0.996	0.000
F01.1 Multi-infarct dementia	0.000	0.996	0.004
F06.3 Organic mood [affective] disorders	0.000	0.996	0.004
F06.6 Organic emotionally labile [asthenic] disorder	0.000	0.996	0.004
F06.5 Organic dissociative disorder	0.000	0.996	0.004
F06.4 Organic anxiety disorder	0.000	0.996	0.004
F06.1 Organic catatonic disorder	0.000	0.996	0.004
F06.0 Organic hallucinosis	0.000	0.996	0.004
N76.0 Acute vaginitis	0.004	0.996	0.000
F01.8 Other vascular dementia	0.000	0.996	0.004
F01.3 Mixed cortical and subcortical vascular dementia	0.000	0.996	0.004
F01.2 Subcortical vascular dementia	0.000	0.996	0.004
F01.0 Vascular dementia of acute onset	0.000	0.996	0.004
F06.2 Organic delusional [schizophrenia-like] disorder	0.000	0.996	0.004
S92.2 Fracture of other tarsal bone(s)	0.004	0.996	0.000
H73.9 Disorder of tympanic membrane, unspecified	0.004	0.996	0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis	0.000	0.996	0.004
O41.9 Disorder of amniotic fluid and membranes, unspecified	0.000	0.996	0.004
H70 Mastoiditis and related conditions	0.004	0.996	0.000
H65.1 Other acute nonsuppurative otitis media	0.004	0.996	0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage	0.000	0.996	0.004
L28.1 Prurigo nodularis	0.004	0.996	0.000
I37.1 Pulmonary valve insufficiency	0.000	0.996	0.004
S92.00 Fracture of calcaneus (closed)	0.004	0.996	0.000
S92.0 Fracture of calcaneus	0.004	0.996	0.000
F06.8 Other specified mental disorders due to brain damage and dysfunction and to physical disease	0.000	0.996	0.003
F06.7 Mild cognitive disorder	0.000	0.996	0.004
S92 Fracture of foot, except ankle	0.004	0.996	0.000
F00 Dementia in Alzheimer's disease	0.000	0.996	0.003
N48.1 Balanoposthitis	0.000	0.997	0.003
N64.9 Disorder of breast, unspecified	0.000	0.997	0.003
S92.3 Fracture of metatarsal bone	0.003	0.997	0.000
S92.30 Fracture of metatarsal bone (closed)	0.003	0.997	0.000
H69.0 Patulous Eustachian tube	0.003	0.997	0.000
B97.7 Papillomavirus as the cause of diseases classified to other chapters	0.003	0.997	0.000
H70.1 Chronic mastoiditis	0.003	0.997	0.000
C79.8 Secondary malignant neoplasm of other specified sites	0.000	0.997	0.003
Z50.2 Alcohol rehabilitation	0.000	0.997	0.003
H65.9 Nonsuppurative otitis media, unspecified	0.003	0.997	0.000
H65.0 Acute serous otitis media	0.003	0.997	0.000
O35.1 Maternal care for (suspected) chromosomal abnormality in foetus	0.000	0.997	0.003
S92.21 Fracture of other tarsal bone(s) (open)	0.003	0.997	0.000
F01.9 Vascular dementia, unspecified	0.000	0.997	0.003
Y79 Orthopaedic devices associated with adverse incidents	0.003	0.997	0.000
I69.1 Sequelae of intracerebral haemorrhage	0.000	0.997	0.003
M84.1 Nonunion of fracture [pseudarthrosis]	0.000	0.997	0.003
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.000	0.997	0.003
H70.2 Petrositis	0.003	0.997	0.000
I67.1 Cerebral aneurysm, nonruptured	0.000	0.997	0.003
M84.15 Nonunion of fracture [pseudarthrosis] (Pelvic region and thigh)	0.000	0.997	0.003
I72.4 Aneurysm of artery of lower extremity	0.000	0.997	0.003
Z08.0 Follow-up examination after surgery for malignant neoplasm	0.003	0.997	0.000
N31 Neuromuscular dysfunction of bladder, not elsewhere classified	0.000	0.997	0.003
O36.9 Maternal care for foetal problem, unspecified	0.003	0.997	0.000
T43.0 Tricyclic and tetracyclic antidepressants	0.000	0.997	0.003
O34.1 Maternal care for tumour of corpus uteri	0.000	0.997	0.003
S66.2 Injury of extensor muscle and tendon of thumb at wrist and hand level	0.000	0.997	0.003
M10.97 Gout, unspecified (Ankle and foot)	0.000	0.997	0.003
C79.6 Secondary malignant neoplasm of ovary	0.000	0.997	0.003
S93.0 Dislocation of ankle joint	0.003	0.997	0.000
S92.9 Fracture of foot, unspecified	0.003	0.997	0.000
L93.0 Discoid lupus erythematosus	0.003	0.997	0.000
N31.2 Flaccid neuropathic bladder, not elsewhere classified	0.000	0.997	0.003
R73.9 Hyperglycaemia, unspecified	0.000	0.997	0.003
Z85.1 Personal history of malignant neoplasm of trachea, bronchus and lung	0.000	0.997	0.003
H69.9 Eustachian tube disorder, unspecified	0.003	0.997	0.000
S92.4 Fracture of great toe	0.003	0.997	0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.003	0.997	0.000
S92.01 Fracture of calcaneus (open)	0.003	0.997	0.000
H70.8 Other mastoiditis and related conditions	0.002	0.997	0.000
H70.0 Acute mastoiditis	0.002	0.997	0.000
S92.31 Fracture of metatarsal bone (open)	0.003	0.997	0.000
N31.1 Reflex neuropathic bladder, not elsewhere classified	0.000	0.997	0.003
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs	0.000	0.997	0.003
F00.2 Dementia in Alzheimer's disease, atypical or mixed type	0.000	0.997	0.003
I72.3 Aneurysm of iliac artery	0.000	0.997	0.003
O34.4 Maternal care for other abnormalities of cervix	0.000	0.997	0.003
H69.8 Other specified disorders of Eustachian tube	0.002	0.997	0.000
M79.84 Other specified soft tissue disorders (Hand)	0.003	0.997	0.000
S92.5 Fracture of other toe	0.003	0.997	0.000
M80.00 Postmenopausal osteoporosis with pathological fracture (Multiple sites)	0.003	0.997	0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow	0.000	0.997	0.003
C18 Malignant neoplasm of colon	0.003	0.997	0.000
S92.7 Multiple fractures of foot	0.003	0.997	0.000
F43.0 Acute stress reaction	0.000	0.997	0.003
Y79.8 Miscellaneous devices, not elsewhere classified	0.002	0.997	0.000
Y79.1 Therapeutic (nonsurgical) and rehabilitative devices	0.002	0.997	0.000
Y79.0 Diagnostic and monitoring devices	0.002	0.997	0.000
O35 Maternal care for known or suspected foetal abnormality and damage	0.000	0.997	0.003
M84.19 Nonunion of fracture [pseudarthrosis] (Site unspecified)	0.000	0.997	0.002
M84.10 Nonunion of fracture [pseudarthrosis] (Multiple sites)	0.000	0.997	0.002
S92.90 Fracture of foot, unspecified (closed)	0.002	0.997	0.000
N02.9 Unspecified	0.003	0.997	0.000
O35.9 Maternal care for (suspected) foetal abnormality and damage, unspecified	0.000	0.997	0.003
O35.0 Maternal care for (suspected) central nervous system malformation in foetus	0.000	0.997	0.002
Y79.3 Surgical instruments, materials and devices (including sutures)	0.002	0.997	0.000
S82.00 Fracture of patella (closed)	0.003	0.997	0.000
M84.16 Nonunion of fracture [pseudarthrosis] (Lower leg)	0.000	0.997	0.002
F00.1 Dementia in Alzheimer's disease with late onset	0.000	0.997	0.002
Q43.3 Congenital malformations of intestinal fixation	0.000	0.997	0.002
M80.10 Postoophorectomy osteoporosis with pathological fracture (Multiple sites)	0.002	0.997	0.000
N31.0 Uninhibited neuropathic bladder, not elsewhere classified	0.000	0.997	0.002
Z35.2 Supervision of pregnancy with other poor reproductive or obstetric history	0.003	0.997	0.000
S92.41 Fracture of great toe (open)	0.002	0.998	0.000
Q43.8 Other specified congenital malformations of intestine	0.000	0.998	0.002
H65.2 Chronic serous otitis media	0.002	0.998	0.000
M84.13 Nonunion of fracture [pseudarthrosis] (Forearm)	0.000	0.998	0.002
S92.91 Fracture of foot, unspecified (open)	0.002	0.998	0.000
C18.8 Overlapping lesion of colon	0.002	0.998	0.000
M84.18 Nonunion of fracture [pseudarthrosis] (Other)	0.000	0.998	0.002
M84.14 Nonunion of fracture [pseudarthrosis] (Hand)	0.000	0.998	0.002
I72 Other aneurysm	0.000	0.998	0.002
C18.5 Splenic flexure	0.002	0.998	0.000
S92.1 Fracture of talus	0.002	0.998	0.000
S92.40 Fracture of great toe (closed)	0.002	0.998	0.000
H60.1 Cellulitis of external ear	0.002	0.998	0.000
T86 Failure and rejection of transplanted organs and tissues	0.002	0.998	0.000
M84.11 Nonunion of fracture [pseudarthrosis] (Shoulder region)	0.000	0.998	0.002
O34 Maternal care for known or suspected abnormality of pelvic organs	0.000	0.998	0.002
S92.51 Fracture of other toe (open)	0.002	0.998	0.000
C18.7 Sigmoid colon	0.002	0.998	0.000
H70.9 Mastoiditis, unspecified	0.002	0.998	0.000
O12.0 Gestational oedema	0.000	0.998	0.002
H60 Otitis externa	0.002	0.998	0.000
S92.71 Multiple fractures of foot (open)	0.002	0.998	0.000
Q43.9 Congenital malformation of intestine, unspecified	0.000	0.998	0.002
F00.0 Dementia in Alzheimer's disease with early onset	0.000	0.998	0.002
H60.0 Abscess of external ear	0.002	0.998	0.000
M07.3 Other psoriatic arthropathies	0.000	0.998	0.002
T86.9 Failure and rejection of unspecified transplanted organ and tissue	0.002	0.998	0.000
Q43 Other congenital malformations of intestine	0.000	0.998	0.002
M21.37 Wrist or foot drop (acquired) (Ankle and foot)	0.002	0.998	0.000
C18.0 Caecum	0.002	0.998	0.000
F00.9 Dementia in Alzheimer's disease, unspecified	0.000	0.998	0.002
N48.8 Other specified disorders of penis	0.000	0.998	0.002
O35.7 Maternal care for (suspected) damage to foetus by other medical procedures	0.000	0.998	0.002
O35.6 Maternal care for (suspected) damage to foetus by radiation	0.000	0.998	0.002
O35.5 Maternal care for (suspected) damage to foetus by drugs	0.000	0.998	0.002
O35.4 Maternal care for (suspected) damage to foetus from alcohol	0.000	0.998	0.002
O35.3 Maternal care for (suspected) damage to foetus from viral disease in mother	0.000	0.998	0.002
O35.2 Maternal care for (suspected) hereditary disease in foetus	0.000	0.998	0.002
F45.8 Other somatoform disorders	0.002	0.998	0.000
H74 Other disorders of middle ear and mastoid	0.002	0.998	0.000
M70.65 Trochanteric bursitis-Pelvic/Thigh	0.000	0.998	0.002
H60.2 Malignant otitis externa	0.002	0.998	0.000
I72.1 Aneurysm of artery of upper extremity	0.000	0.998	0.002
M84.17 Nonunion of fracture [pseudarthrosis] (Ankle and foot)	0.000	0.998	0.002
M84.48 Pathological fracture, not elsewhere classified (Other)	0.000	0.998	0.002
M84.4 Pathological fracture, not elsewhere classified	0.000	0.998	0.002
H74.2 Discontinuity and dislocation of ear ossicles	0.002	0.998	0.000
O34.7 Maternal care for abnormality of vulva and perineum	0.000	0.998	0.002
O34.8 Maternal care for other abnormalities of pelvic organs	0.000	0.998	0.002
Z98.1 Arthrodesis status	0.002	0.998	0.000
S92.50 Fracture of other toe (closed)	0.002	0.998	0.000
S92.70 Multiple fractures of foot (closed)	0.002	0.998	0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.002	0.998	0.000
S36.00 Injury of spleen (without open wound into cavity)	0.000	0.998	0.002
H60.9 Otitis externa, unspecified	0.002	0.998	0.000
I72.6 Aneurysm and dissection of vertebral artery	0.000	0.998	0.002
I72.5 Aneurysm and dissection of other precerebral arteries	0.000	0.998	0.002
O34.5 Maternal care for other abnormalities of gravid uterus	0.000	0.998	0.002
S92.11 Fracture of talus (open)	0.002	0.998	0.000
M80.0 Postmenopausal osteoporosis with pathological fracture	0.002	0.998	0.000
I37 Pulmonary valve disorders	0.000	0.998	0.002
H60.5 Acute otitis externa, non-infective	0.002	0.998	0.000
I72.8 Aneurysm of other specified arteries	0.000	0.998	0.002
D51 Vitamin B12 deficiency anaemia	0.000	0.998	0.002
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)	0.000	0.998	0.002
M70.46 Prepatellar bursitis-Lower Leg	0.002	0.998	0.000
M84.42 Pathological fracture, not elsewhere classified (Upper arm)	0.000	0.998	0.002
I72.9 Aneurysm of unspecified site	0.000	0.998	0.002
I72.2 Aneurysm of renal artery	0.000	0.998	0.002
O12.2 Gestational oedema with proteinuria	0.000	0.998	0.002
O36.5 Maternal care for poor foetal growth	0.000	0.998	0.002
T86.4 Liver transplant failure and rejection	0.002	0.998	0.000
M84.45 Pathological fracture, not elsewhere classified (Pelvic region and thigh)	0.000	0.998	0.002
S82.01 Fracture of patella (open)	0.002	0.998	0.000
O35.8 Maternal care for other (suspected) foetal abnormality and damage	0.000	0.998	0.002
R82.9 Other and unspecified abnormal finding in urine	0.000	0.998	0.002
T86.3 Heart-lung transplant failure and rejection	0.002	0.998	0.000
T86.2 Heart transplant failure and rejection	0.002	0.998	0.000
H60.8 Other otitis externa	0.002	0.998	0.000
H74.1 Adhesive middle ear disease	0.002	0.998	0.000
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.002	0.998	0.000
O34.9 Maternal care for abnormality of pelvic organ, unspecified	0.000	0.998	0.002
O34.6 Maternal care for abnormality of vagina	0.000	0.998	0.002
R82.5 Elevated urine levels of drugs, medicaments and biological substances	0.000	0.998	0.002
M07.31 Other psoriatic arthropathies (Shoulder region)	0.000	0.998	0.002
C18.1 Appendix	0.002	0.998	0.000
O30.0 Twin pregnancy	0.000	0.998	0.002
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension	0.000	0.998	0.002
M07.33 Other psoriatic arthropathies (Forearm)	0.000	0.998	0.002
M07.32 Other psoriatic arthropathies (Upper arm)	0.000	0.998	0.002
S62.00 Fracture of navicular [scaphoid] bone of hand (closed)	0.000	0.998	0.002
D58.0 Hereditary spherocytosis	0.002	0.998	0.000
I37.0 Pulmonary valve stenosis	0.000	0.998	0.002
M84 Disorders of continuity of bone	0.000	0.998	0.002
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria	0.000	0.998	0.002
D51.8 Other vitamin B12 deficiency anaemias	0.000	0.998	0.002
H60.3 Other infective otitis externa	0.002	0.998	0.000
Q43.7 Persistent cloaca	0.000	0.998	0.002
Q43.6 Congenital fistula of rectum and anus	0.000	0.998	0.002
Q43.5 Ectopic anus	0.000	0.998	0.002
Q43.4 Duplication of intestine	0.000	0.998	0.002
Q43.2 Other congenital functional disorders of colon	0.000	0.998	0.002
M07.37 Other psoriatic arthropathies (Ankle and foot)	0.000	0.998	0.002
N48.0 Leukoplakia of penis	0.000	0.998	0.002
M23.30 Other meniscus derangements (Multiple sites)	0.000	0.998	0.002
M84.40 Pathological fracture, not elsewhere classified (Multiple sites)	0.000	0.998	0.002
I72.0 Aneurysm of carotid artery	0.000	0.998	0.002
M07.39 Other psoriatic arthropathies (Site unspecified)	0.000	0.998	0.002
M84.49 Pathological fracture, not elsewhere classified (Site unspecified)	0.000	0.998	0.002
M84.47 Pathological fracture, not elsewhere classified (Ankle and foot)	0.000	0.998	0.002
M84.46 Pathological fracture, not elsewhere classified (Lower leg)	0.000	0.998	0.002
M84.44 Pathological fracture, not elsewhere classified (Hand)	0.000	0.998	0.002
M84.43 Pathological fracture, not elsewhere classified (Forearm)	0.000	0.998	0.002
D51.3 Other dietary vitamin B12 deficiency anaemia	0.000	0.998	0.002
J84.8 Other specified interstitial pulmonary diseases	0.002	0.998	0.000
O34.3 Maternal care for cervical incompetence	0.000	0.998	0.002
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms	0.000	0.998	0.002
H60.4 Cholesteatoma of external ear	0.002	0.998	0.000
R00.1 Bradycardia, unspecified	0.002	0.998	0.000
M07.36 Other psoriatic arthropathies (Lower leg)	0.000	0.998	0.002
D58.9 Hereditary haemolytic anaemia, unspecified	0.002	0.998	0.000
O34.0 Maternal care for congenital malformation of uterus	0.000	0.998	0.002
Q43.1 Hirschsprung's disease	0.000	0.998	0.002
S93.6 Sprain and strain of other and unspecified parts of foot	0.002	0.998	0.000
M84.8 Other disorders of continuity of bone	0.000	0.998	0.002
C18.4 Transverse colon	0.002	0.998	0.000
H61.3 Acquired stenosis of external ear canal	0.000	0.998	0.002
S93.4 Sprain and strain of ankle	0.002	0.998	0.000
S93.5 Sprain and strain of toe(s)	0.002	0.998	0.000
M80.09 Postmenopausal osteoporosis with pathological fracture (Site unspecified)	0.002	0.998	0.000
M80.08 Postmenopausal osteoporosis with pathological fracture (Other)	0.002	0.998	0.000
M80.07 Postmenopausal osteoporosis with pathological fracture (Ankle and foot)	0.002	0.998	0.000
M80.06 Postmenopausal osteoporosis with pathological fracture (Lower leg)	0.002	0.998	0.000
M80.05 Postmenopausal osteoporosis with pathological fracture (Pelvic region and thigh)	0.002	0.998	0.000
M80.04 Postmenopausal osteoporosis with pathological fracture (Hand)	0.002	0.998	0.000
M80.03 Postmenopausal osteoporosis with pathological fracture (Forearm)	0.002	0.998	0.000
M80.02 Postmenopausal osteoporosis with pathological fracture (Upper arm)	0.002	0.998	0.000
M80.01 Postmenopausal osteoporosis with pathological fracture (Shoulder region)	0.002	0.998	0.000
D48.5 Skin	0.002	0.998	0.000
I37.9 Pulmonary valve disorder, unspecified	0.000	0.998	0.002
I37.8 Other pulmonary valve disorders	0.000	0.998	0.002
I37.2 Pulmonary valve stenosis with insufficiency	0.000	0.998	0.002
R82.7 Abnormal findings on microbiological examination of urine	0.000	0.998	0.002
S82.0 Fracture of patella	0.002	0.998	0.000
Z00.0 General medical examination	0.000	0.998	0.002
Z52.8 Donor of other organs and tissues	0.002	0.998	0.000
M84.41 Pathological fracture, not elsewhere classified (Shoulder region)	0.000	0.998	0.001
D51.2 Transcobalamin II deficiency	0.000	0.998	0.002
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria	0.000	0.998	0.002
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.000	0.998	0.002
H01.8 Other specified inflammation of eyelid	0.002	0.998	0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis	0.002	0.998	0.000
M80.19 Postoophorectomy osteoporosis with pathological fracture (Site unspecified)	0.001	0.998	0.000
M80.18 Postoophorectomy osteoporosis with pathological fracture (Other)	0.001	0.998	0.000
M80.17 Postoophorectomy osteoporosis with pathological fracture (Ankle and foot)	0.001	0.998	0.000
M80.16 Postoophorectomy osteoporosis with pathological fracture (Lower leg)	0.001	0.998	0.000
M80.15 Postoophorectomy osteoporosis with pathological fracture (Pelvic region and thigh)	0.001	0.998	0.000
M80.14 Postoophorectomy osteoporosis with pathological fracture (Hand)	0.001	0.998	0.000
M80.13 Postoophorectomy osteoporosis with pathological fracture (Forearm)	0.001	0.998	0.000
M80.12 Postoophorectomy osteoporosis with pathological fracture (Upper arm)	0.001	0.998	0.000
M80.11 Postoophorectomy osteoporosis with pathological fracture (Shoulder region)	0.001	0.998	0.000
M84.87 Other disorders of continuity of bone (Ankle and foot)	0.000	0.998	0.002
G72.0 Drug-induced myopathy	0.002	0.998	0.000
S93.1 Dislocation of toe(s)	0.002	0.998	0.000
T93.0 Sequelae of open wound of lower limb	0.000	0.998	0.002
R82 Other abnormal findings in urine	0.000	0.998	0.002
S22 Fracture of rib(s), sternum and thoracic spine	0.000	0.998	0.002
S90-S99 Injuries to the ankle and foot	0.002	0.998	0.000
C18.6 Descending colon	0.002	0.998	0.000
N48 Other disorders of penis	0.000	0.998	0.002
M07.38 Other psoriatic arthropathies (Other)	0.000	0.998	0.001
M84.9 Disorder of continuity of bone, unspecified	0.000	0.998	0.001
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.002	0.998	0.000
M84.2 Delayed union of fracture	0.000	0.998	0.001
O12.1 Gestational proteinuria	0.000	0.998	0.001
S97 Crushing injury of ankle and foot	0.001	0.998	0.000
L29.2 Pruritus vulvae	0.000	0.998	0.002
S93.2 Rupture of ligaments at ankle and foot level	0.001	0.998	0.000
B49 Unspecified mycosis	0.000	0.998	0.002
M62.66 Muscle strain (Lower leg)	0.001	0.998	0.000
E26.0 Primary hyperaldosteronism	0.000	0.998	0.002
J84.9 Interstitial pulmonary disease, unspecified	0.002	0.998	0.000
N76.5 Ulceration of vagina	0.002	0.998	0.000
H74.9 Disorder of middle ear and mastoid, unspecified	0.001	0.998	0.000
R94.3 Abnormal results of cardiovascular function studies	0.000	0.998	0.002
S97.1 Crushing injury of toe(s)	0.001	0.998	0.000
T82.3 Mechanical complication of other vascular grafts	0.000	0.998	0.002
M10.93 Gout, unspecified (Forearm)	0.000	0.998	0.001
C69.9 Eye, unspecified	0.001	0.998	0.000
M84.3 Stress fracture, not elsewhere classified	0.000	0.998	0.001
S98 Traumatic amputation of ankle and foot	0.001	0.998	0.000
M07.34 Other psoriatic arthropathies (Hand)	0.000	0.998	0.001
M84.89 Other disorders of continuity of bone (Site unspecified)	0.000	0.998	0.001
M84.88 Other disorders of continuity of bone (Other)	0.000	0.998	0.001
M84.86 Other disorders of continuity of bone (Lower leg)	0.000	0.998	0.001
M84.85 Other disorders of continuity of bone (Pelvic region and thigh)	0.000	0.998	0.001
M84.84 Other disorders of continuity of bone (Hand)	0.000	0.998	0.001
M84.82 Other disorders of continuity of bone (Upper arm)	0.000	0.998	0.001
M84.81 Other disorders of continuity of bone (Shoulder region)	0.000	0.998	0.001
M84.80 Other disorders of continuity of bone (Multiple sites)	0.000	0.998	0.001
S93.40 Sprain of unspecified ligament of ankle	0.001	0.998	0.000
E26.9 Hyperaldosteronism, unspecified	0.000	0.998	0.001
Y72 Otorhinolaryngological devices associated with adverse incidents	0.001	0.998	0.000
M66.24 Spontaneous rupture of extensor tendons (Hand)	0.001	0.999	0.000
M70.22 Olecranon bursitis-Upper arm	0.001	0.999	0.000
S92.10 Fracture of talus (closed)	0.001	0.999	0.001
Y71 Cardiovascular devices associated with adverse incidents	0.001	0.999	0.000
M84.26 Delayed union of fracture (Lower leg)	0.000	0.999	0.001
M84.83 Other disorders of continuity of bone (Forearm)	0.000	0.999	0.001
C38.4 Pleura	0.001	0.999	0.000
R01.0 Benign and innocent cardiac murmurs	0.001	0.999	0.000
Y73 Gastro-enterology and urology devices associated with adverse incidents	0.001	0.999	0.000
N48.5 Ulcer of penis	0.000	0.999	0.001
R82.6 Abnormal urine levels of substances chiefly nonmedicinal as to source	0.000	0.999	0.001
R82.3 Haemoglobinuria	0.000	0.999	0.001
R82.2 Biliuria	0.000	0.999	0.001
R82.0 Chyluria	0.000	0.999	0.001
S22.1 Multiple fractures of thoracic spine	0.000	0.999	0.001
Y49.2 Other and unspecified antidepressants	0.000	0.999	0.001
Y71.1 Therapeutic (nonsurgical) and rehabilitative devices	0.001	0.999	0.000
Y88.3 Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient or of later complication, without mention of misadventure at the time of the procedure	0.001	0.999	0.000
D58 Other hereditary haemolytic anaemias	0.001	0.999	0.000
Y82 Other and unspecified medical devices associated with adverse incidents	0.001	0.999	0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.001	0.999	0.000
Q53.1 Undescended testicle, unilateral	0.000	0.999	0.001
S22.9 Fracture of bony thorax, part unspecified	0.000	0.999	0.001
S22.8 Fracture of other parts of bony thorax	0.000	0.999	0.001
S98.1 Traumatic amputation of one toe	0.001	0.999	0.000
Y72.2 Prosthetic and other implants, materials and accessory devices	0.001	0.999	0.000
O11 Pre-existing hypertensive disorder with superimposed proteinuria	0.000	0.999	0.001
S95 Injury of blood vessels at ankle and foot level	0.001	0.999	0.000
S94 Injury of nerves at ankle and foot level	0.001	0.999	0.000
M84.99 Disorder of continuity of bone, unspecified (Site unspecified)	0.000	0.999	0.001
M84.98 Disorder of continuity of bone, unspecified (Other)	0.000	0.999	0.001
M84.97 Disorder of continuity of bone, unspecified (Ankle and foot)	0.000	0.999	0.001
M84.96 Disorder of continuity of bone, unspecified (Lower leg)	0.000	0.999	0.001
M84.95 Disorder of continuity of bone, unspecified (Pelvic region and thigh)	0.000	0.999	0.001
M84.94 Disorder of continuity of bone, unspecified (Hand)	0.000	0.999	0.001
M84.93 Disorder of continuity of bone, unspecified (Forearm)	0.000	0.999	0.001
M84.92 Disorder of continuity of bone, unspecified (Upper arm)	0.000	0.999	0.001
M84.91 Disorder of continuity of bone, unspecified (Shoulder region)	0.000	0.999	0.001
M84.90 Disorder of continuity of bone, unspecified (Multiple sites)	0.000	0.999	0.001
N76.1 Subacute and chronic vaginitis	0.001	0.999	0.000
O02.0 Blighted ovum and nonhydatidiform mole	0.001	0.999	0.000
S93.3 Dislocation of other and unspecified parts of foot	0.001	0.999	0.000
S97.8 Crushing injury of other parts of ankle and foot	0.001	0.999	0.000
Z35.9 Supervision of high-risk pregnancy, unspecified	0.001	0.999	0.000
Y80 Physical medicine devices associated with adverse incidents	0.001	0.999	0.000
Y78 Radiological devices associated with adverse incidents	0.001	0.999	0.000
Y75 Neurological devices associated with adverse incidents	0.001	0.999	0.000
Y74 General hospital and personal-use devices associated with adverse incidents	0.001	0.999	0.000
Y70 Anaesthesiology devices associated with adverse incidents	0.001	0.999	0.000
M84.29 Delayed union of fracture (Site unspecified)	0.000	0.999	0.001
M84.28 Delayed union of fracture (Other)	0.000	0.999	0.001
M84.27 Delayed union of fracture (Ankle and foot)	0.000	0.999	0.001
M84.25 Delayed union of fracture (Pelvic region and thigh)	0.000	0.999	0.001
M84.24 Delayed union of fracture (Hand)	0.000	0.999	0.001
M84.23 Delayed union of fracture (Forearm)	0.000	0.999	0.001
M84.22 Delayed union of fracture (Upper arm)	0.000	0.999	0.001
M84.20 Delayed union of fracture (Multiple sites)	0.000	0.999	0.001
Q39.4 Oesophageal web	0.000	0.999	0.001
S97.0 Crushing injury of ankle	0.001	0.999	0.000
Y52.3 Coronary vasodilators, not elsewhere classified	0.000	0.999	0.001
M80.88 Other osteoporosis with pathological fracture (Other)	0.001	0.999	0.000
Y81 General- and plastic-surgery devices associated with adverse incidents	0.001	0.999	0.000
T02.40 Fractures involving multiple regions of both upper limbs (closed)	0.000	0.999	0.001
C18.9 Colon, unspecified	0.001	0.999	0.000
Q43.0 Meckel's diverticulum	0.000	0.999	0.001
M80 Osteoporosis with pathological fracture	0.001	0.999	0.000
M84.39 Stress fracture, not elsewhere classified (Site unspecified)	0.000	0.999	0.001
M84.38 Stress fracture, not elsewhere classified (Other)	0.000	0.999	0.001
M84.36 Stress fracture, not elsewhere classified (Lower leg)	0.000	0.999	0.001
M84.35 Stress fracture, not elsewhere classified (Pelvic region and thigh)	0.000	0.999	0.001
M84.34 Stress fracture, not elsewhere classified (Hand)	0.000	0.999	0.001
M84.33 Stress fracture, not elsewhere classified (Forearm)	0.000	0.999	0.001
M84.32 Stress fracture, not elsewhere classified (Upper arm)	0.000	0.999	0.001
M84.31 Stress fracture, not elsewhere classified (Shoulder region)	0.000	0.999	0.001
M84.30 Stress fracture, not elsewhere classified (Multiple sites)	0.000	0.999	0.001
S02.20 Fracture of nasal bones (closed)	0.001	0.999	0.000
H74.0 Tympanosclerosis	0.001	0.999	0.000
I22.0 Subsequent myocardial infarction of anterior wall	0.000	0.999	0.001
M80.8 Other osteoporosis with pathological fracture	0.001	0.999	0.000
N48.3 Priapism	0.000	0.999	0.001
S98.4 Traumatic amputation of foot, level unspecified	0.001	0.999	0.000
S98.3 Traumatic amputation of other parts of foot	0.001	0.999	0.000
S98.2 Traumatic amputation of two or more toes	0.001	0.999	0.000
S98.0 Traumatic amputation of foot at ankle level	0.001	0.999	0.000
Y72.8 Miscellaneous devices, not elsewhere classified	0.001	0.999	0.000
Y72.3 Surgical instruments, materials and devices (including sutures)	0.001	0.999	0.000
Y72.1 Therapeutic (nonsurgical) and rehabilitative devices	0.001	0.999	0.000
Y72.0 Diagnostic and monitoring devices	0.001	0.999	0.000
Y73.0 Diagnostic and monitoring devices	0.001	0.999	0.000
N76 Other inflammation of vagina and vulva	0.001	0.999	0.000
Y77 Ophthalmic devices associated with adverse incidents	0.001	0.999	0.000
M25.75 Osteophyte (Pelvic region and thigh)	0.001	0.999	0.000
D47.3 Essential (haemorrhagic) thrombocythaemia	0.001	0.999	0.000
Y71.8 Miscellaneous devices, not elsewhere classified	0.001	0.999	0.000
Y71.3 Surgical instruments, materials and devices (including sutures)	0.001	0.999	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations