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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs447088
log Bayes Factor = 10.172
Chromosome 6   position 32,979,980  (GRCh37) Explore rs447088 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
E10.3 With ophthalmic complications
1.000 0.000 0.000
E10.4 With neurological complications
0.920 0.080 0.000
E10.2 With renal complications
0.914 0.086 0.000
E10-E14 Diabetes mellitus
0.910 0.090 0.000
E10.6 With other specified complications
0.865 0.135 0.000
E11 Non-insulin-dependent diabetes mellitus
0.862 0.138 0.000
E10.0 With coma
0.855 0.145 0.000
E11.2 With renal complications
0.845 0.155 0.000
E10.8 With unspecified complications
0.845 0.155 0.000
E10.7 With multiple complications
0.834 0.166 0.000
E10.1 With ketoacidosis
0.802 0.198 0.000
E13 Other specified diabetes mellitus
0.783 0.217 0.000
E10.5 With peripheral circulatory complications
0.781 0.219 0.000
E11.3 With ophthalmic complications
0.713 0.287 0.000
E14 Unspecified diabetes mellitus
0.681 0.319 0.000
E11.5 With peripheral circulatory complications
0.673 0.327 0.000
E11.1 With ketoacidosis
0.655 0.345 0.000
E13.9 Without complications
0.654 0.346 0.000
E12 Malnutrition-related diabetes mellitus
0.652 0.348 0.000
E13.3 With ophthalmic complications
0.627 0.373 0.000
E11.7 With multiple complications
0.618 0.382 0.000
E11.6 With other specified complications
0.617 0.383 0.000
E14.3 With ophthalmic complications
0.595 0.405 0.000
E13.8 With unspecified complications
0.561 0.438 0.000
E13.7 With multiple complications
0.561 0.438 0.000
E13.6 With other specified complications
0.561 0.438 0.000
E13.5 With peripheral circulatory complications
0.561 0.438 0.000
E13.4 With neurological complications
0.561 0.438 0.000
E13.2 With renal complications
0.561 0.438 0.000
E13.1 With ketoacidosis
0.561 0.438 0.000
E13.0 With coma
0.561 0.438 0.000
E14.6 With other specified complications
0.560 0.440 0.000
E11.8 With unspecified complications
0.549 0.451 0.000
E11.0 With coma
0.539 0.461 0.000
E14.2 Withrenal complications
0.527 0.473 0.000
E14.8 With unspecified complications
0.490 0.510 0.000
E14.7 With multiple complications
0.488 0.512 0.000
E14.5 With peripheral circulatory complications
0.488 0.512 0.000
E14.0 With coma
0.488 0.512 0.000
E11.4 With neurological complications
0.481 0.519 0.000
E12.9 Without complications
0.468 0.532 0.000
E12.8 With unspecified complications
0.468 0.532 0.000
E12.7 With multiple complications
0.468 0.532 0.000
E12.6 With other specified complications
0.468 0.532 0.000
E12.5 With peripheral circulatory complications
0.468 0.532 0.000
E12.4 With neurological complications
0.468 0.532 0.000
E12.3 With ophthalmic complications
0.468 0.532 0.000
E12.2 With renal complications
0.468 0.532 0.000
E12.1 With ketoacidosis
0.468 0.532 0.000
E12.0 With coma
0.468 0.532 0.000
E14.1 With ketoacidosis
0.459 0.540 0.000
E11.9 Without complications
0.423 0.577 0.000
E14.4 With neurological complications
0.376 0.623 0.000
E14.9 Without complications
0.277 0.723 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.105 0.895 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.099 0.901 0.000
E16 Other disorders of pancreatic internal secretion
0.096 0.904 0.000
E16.2 Hypoglycaemia, unspecified
0.094 0.906 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.082 0.918 0.000
E00-E07 Disorders of thyroid gland
0.079 0.921 0.000
E03 Other hypothyroidism
0.074 0.926 0.000
E40-E46 Malnutrition
0.072 0.927 0.000
E03.9 Hypothyroidism, unspecified
0.072 0.928 0.000
E15 Nondiabetic hypoglycaemic coma
0.071 0.928 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.069 0.931 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.069 0.931 0.000
E16.4 Abnormal secretion of gastrin
0.069 0.931 0.000
E16.3 Increased secretion of glucagon
0.069 0.931 0.000
E50-E64 Other nutritional deficiencies
0.064 0.936 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.000 0.936 0.064
T42.4 Benzodiazepines
0.000 0.936 0.064
T36-T50 Poisoning by drugs, medicaments and biological substances
0.000 0.937 0.063
E06 Thyroiditis
0.062 0.938 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.000 0.940 0.060
T50.9 Other and unspecified drugs, medicaments and biological substances
0.000 0.941 0.059
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.000 0.941 0.059
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.000 0.941 0.059
E02 Subclinical iodine-deficiency hypothyroidism
0.058 0.942 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.000 0.942 0.058
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.057 0.943 0.000
E00 Congenital iodine-deficiency syndrome
0.057 0.943 0.000
E03.8 Other specified hypothyroidism
0.057 0.943 0.000
T39.1 4-Aminophenol derivatives
0.000 0.944 0.056
E53 Deficiency of other B group vitamins
0.054 0.946 0.000
E07 Other disorders of thyroid
0.054 0.946 0.000
E03.5 Myxoedema coma
0.053 0.946 0.000
E03.4 Atrophy of thyroid (acquired)
0.053 0.946 0.000
E03.3 Postinfectious hypothyroidism
0.053 0.946 0.000
E03.1 Congenital hypothyroidism without goitre
0.053 0.946 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.053 0.946 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.052 0.948 0.000
E45 Retarded development following protein-energy malnutrition
0.052 0.948 0.000
E43 Unspecified severe protein-energy malnutrition
0.052 0.948 0.000
E42 Marasmic kwashiorkor
0.052 0.948 0.000
E41 Nutritional marasmus
0.052 0.948 0.000
E40 Kwashiorkor
0.052 0.948 0.000
E06.9 Thyroiditis, unspecified
0.051 0.948 0.000
T40.4 Other synthetic narcotics
0.000 0.948 0.052
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.000 0.949 0.051
T36 Poisoning by systemic antibiotics
0.000 0.949 0.051
E04 Other non-toxic goitre
0.051 0.949 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.000 0.949 0.051
E46 Unspecified protein-energy malnutrition
0.050 0.950 0.000
T40.2 Other opioids
0.000 0.950 0.050
E53.8 Deficiency of other specified B group vitamins
0.049 0.951 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.000 0.951 0.049
T42.0 Hydantoin derivatives
0.000 0.951 0.049
T40.6 Other and unspecified narcotics
0.000 0.952 0.048
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.000 0.952 0.048
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.000 0.952 0.048
E16.1 Other hypoglycaemia
0.046 0.953 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.000 0.953 0.046
E64 Sequelae of malnutrition and other nutritional deficiencies
0.046 0.954 0.000
E63 Other nutritional deficiencies
0.046 0.954 0.000
E56 Other vitamin deficiencies
0.046 0.954 0.000
E51 Thiamine deficiency
0.046 0.954 0.000
E50 Vitamin A deficiency
0.046 0.954 0.000
E60 Dietary zinc deficiency
0.046 0.954 0.000
E59 Dietary selenium deficiency
0.046 0.954 0.000
E58 Dietary calcium deficiency
0.046 0.954 0.000
E54 Ascorbic acid deficiency
0.046 0.954 0.000
E52 Niacin deficiency [pellagra]
0.046 0.954 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.000 0.954 0.046
T42.2 Succinimides and oxazolidinediones
0.000 0.954 0.046
E06.5 Other chronic thyroiditis
0.046 0.954 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.000 0.954 0.045
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.000 0.954 0.045
T41 Poisoning by anaesthetics and therapeutic gases
0.000 0.954 0.045
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.000 0.955 0.045
E06.4 Drug-induced thyroiditis
0.045 0.955 0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.045 0.955 0.000
E06.1 Subacute thyroiditis
0.045 0.955 0.000
E06.0 Acute thyroiditis
0.045 0.955 0.000
E07.9 Disorder of thyroid, unspecified
0.045 0.955 0.000
E04.2 Non-toxic multinodular goitre
0.044 0.956 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.000 0.956 0.044
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.044 0.956 0.000
T47.1 Other antacids and anti-gastric-secretion drugs
0.000 0.956 0.044
T42.1 Iminostilbenes
0.000 0.956 0.043
T50.7 Analeptics and opioid receptor antagonists
0.000 0.957 0.043
T50.6 Antidotes and chelating agents, not elsewhere classified
0.000 0.957 0.043
T50.5 Appetite depressants
0.000 0.957 0.043
T50.4 Drugs affecting uric acid metabolism
0.000 0.957 0.043
T50.3 Electrolytic, caloric and water-balance agents
0.000 0.957 0.043
T50.1 Loop [high-ceiling] diuretics
0.000 0.957 0.043
T50.0 Mineralocorticoids and their antagonists
0.000 0.957 0.043
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.000 0.957 0.043
T40.9 Other and unspecified psychodysleptics [hallucinogens]
0.000 0.957 0.043
T40.8 Lysergide [LSD]
0.000 0.957 0.043
T40.7 Cannabis (derivatives)
0.000 0.957 0.043
T40.3 Methadone
0.000 0.957 0.043
T40.1 Heroin
0.000 0.957 0.043
T40.0 Opium
0.000 0.957 0.043
T36.0 Penicillins
0.000 0.957 0.042
T39.4 Antirheumatics, not elsewhere classified
0.000 0.958 0.042
T39.2 Pyrazolone derivatives
0.000 0.958 0.042
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.000 0.958 0.042
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.000 0.958 0.041
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.000 0.959 0.041
T40.5 Cocaine
0.000 0.959 0.041
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.041 0.959 0.000
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.041 0.959 0.000
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.041 0.959 0.000
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.041 0.959 0.000
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.041 0.959 0.000
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.041 0.959 0.000
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.041 0.959 0.000
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.041 0.959 0.000
E06.3 Autoimmune thyroiditis
0.040 0.959 0.000
T46.1 Calcium-channel blockers
0.000 0.960 0.040
T42.3 Barbiturates
0.000 0.960 0.040
E65-E68 Obesity and other hyperalimentation
0.039 0.960 0.000
E53.1 Pyridoxine deficiency
0.039 0.961 0.000
E53.0 Riboflavin deficiency
0.039 0.961 0.000
E07.1 Dyshormogenetic goitre
0.039 0.961 0.000
E07.0 Hypersecretion of calcitonin
0.039 0.961 0.000
E44.1 Mild protein-energy malnutrition
0.037 0.962 0.000
E44.0 Moderate protein-energy malnutrition
0.037 0.962 0.000
T38.9 Other and unspecified hormone antagonists
0.000 0.963 0.037
T38.8 Other and unspecified hormones and their synthetic substitutes
0.000 0.963 0.037
T38.7 Androgens and anabolic congeners
0.000 0.963 0.037
T38.5 Other oestrogens and progestogens
0.000 0.963 0.037
T38.4 Oral contraceptives
0.000 0.963 0.037
T38.2 Antithyroid drugs
0.000 0.963 0.037
T38.0 Glucocorticoids and synthetic analogues
0.000 0.963 0.037
T36.9 Systemic antibiotic, unspecified
0.000 0.963 0.037
T36.8 Other systemic antibiotics
0.000 0.963 0.037
T36.7 Antifungal antibiotics, systemically used
0.000 0.963 0.037
T36.6 Rifamycins
0.000 0.963 0.037
T36.5 Aminoglycosides
0.000 0.963 0.037
T36.4 Tetracyclines
0.000 0.963 0.037
T36.3 Macrolides
0.000 0.963 0.037
T36.2 Chloramphenicol group
0.000 0.963 0.037
T36.1 Cefalosporins and other Beta-lactam antibiotics
0.000 0.963 0.037
E04.8 Other specified non-toxic goitre
0.037 0.963 0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified
0.000 0.963 0.037
T47.8 Other agents primarily affecting the gastro-intestinal system
0.000 0.963 0.037
T47.7 Emetics
0.000 0.963 0.037
T47.6 Antidiarrhoeal drugs
0.000 0.963 0.037
T47.5 Digestants
0.000 0.963 0.037
T47.4 Other laxatives
0.000 0.963 0.037
T47.3 Saline and osmotic laxatives
0.000 0.963 0.037
T47.2 Stimulant laxatives
0.000 0.963 0.037
T46.3 Coronary vasodilators, not elsewhere classified
0.000 0.964 0.036
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.000 0.964 0.035
T46.8 Antivaricose drugs, including sclerosing agents
0.000 0.964 0.035
T46.7 Peripheral vasodilators
0.000 0.964 0.035
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.000 0.964 0.035
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.000 0.964 0.035
E61 Deficiency of other nutrient elements
0.035 0.965 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.000 0.965 0.035
T37.8 Other specified systemic anti-infectives and antiparasitics
0.000 0.965 0.035
S92.30 Fracture of metatarsal bone (closed)
0.000 0.966 0.034
E53.9 Vitamin B deficiency, unspecified
0.034 0.966 0.000
T50.8 Diagnostic agents
0.000 0.966 0.034
E04.0 Non-toxic diffuse goitre
0.034 0.966 0.000
T37.9 Systemic anti-infective and antiparasitic, unspecified
0.000 0.966 0.033
T37.5 Antiviral drugs
0.000 0.966 0.033
T37.4 Anthelminthics
0.000 0.966 0.033
T37.3 Other antiprotozoal drugs
0.000 0.966 0.033
T37.2 Antimalarials and drugs acting on other blood protozoa
0.000 0.966 0.033
T37.1 Antimycobacterial drugs
0.000 0.966 0.033
T37.0 Sulphonamides
0.000 0.966 0.033
E50.9 Vitamin A deficiency, unspecified
0.033 0.966 0.000
E50.8 Other manifestations of vitamin A deficiency
0.033 0.966 0.000
E50.7 Other ocular manifestations of vitamin A deficiency
0.033 0.966 0.000
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.033 0.966 0.000
E50.5 Vitamin A deficiency with night blindness
0.033 0.966 0.000
E50.4 Vitamin A deficiency with keratomalacia
0.033 0.966 0.000
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.033 0.966 0.000
E50.2 Vitamin A deficiency with corneal xerosis
0.033 0.966 0.000
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.033 0.966 0.000
E50.0 Vitamin A deficiency with conjunctival xerosis
0.033 0.966 0.000
E51.9 Thiamine deficiency, unspecified
0.033 0.966 0.000
E51.8 Other manifestations of thiamine deficiency
0.033 0.966 0.000
E51.1 Beriberi
0.033 0.966 0.000
E56.9 Vitamin deficiency, unspecified
0.033 0.966 0.000
E56.8 Deficiency of other vitamins
0.033 0.966 0.000
E56.1 Deficiency of vitamin K
0.033 0.966 0.000
E56.0 Deficiency of vitamin E
0.033 0.966 0.000
E63.9 Nutritional deficiency, unspecified
0.033 0.966 0.000
E63.8 Other specified nutritional deficiencies
0.033 0.966 0.000
E63.1 Imbalance of constituents of food intake
0.033 0.966 0.000
E63.0 Essential fatty acid [EFA] deficiency
0.033 0.966 0.000
E64.9 Sequelae of unspecified nutritional deficiency
0.033 0.966 0.000
E64.8 Sequelae of other nutritional deficiencies
0.033 0.966 0.000
E64.3 Sequelae of rickets
0.033 0.966 0.000
E64.2 Sequelae of vitamin C deficiency
0.033 0.966 0.000
E64.1 Sequelae of vitamin A deficiency
0.033 0.966 0.000
E64.0 Sequelae of protein-energy malnutrition
0.033 0.966 0.000
E51.2 Wernicke's encephalopathy
0.033 0.966 0.000
T47.0 Histamine H(2)-receptor antagonists
0.000 0.967 0.033
T41.5 Therapeutic gases
0.000 0.967 0.033
T41.4 Anaesthetic, unspecified
0.000 0.967 0.033
T41.3 Local anaesthetics
0.000 0.967 0.033
T41.2 Other and unspecified general anaesthetics
0.000 0.967 0.033
T41.1 Intravenous anaesthetics
0.000 0.967 0.033
T41.0 Inhaled anaesthetics
0.000 0.967 0.033
T48.7 Other and unspecified agents primarily acting on the respiratory system
0.000 0.967 0.033
T48.6 Antiasthmatics, not elsewhere classified
0.000 0.967 0.033
T48.5 Anti-common-cold drugs
0.000 0.967 0.033
T48.4 Expectorants
0.000 0.967 0.033
T48.3 Antitussives
0.000 0.967 0.033
T48.2 Other and unspecified agents primarily acting on muscles
0.000 0.967 0.033
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]
0.000 0.967 0.033
T48.0 Oxytocic drugs
0.000 0.967 0.033
T49.9 Topical agent, unspecified
0.000 0.967 0.033
T49.8 Other topical agents
0.000 0.967 0.033
T49.7 Dental drugs, topically applied
0.000 0.967 0.033
T49.6 Otorhinolaryngological drugs and preparations
0.000 0.967 0.033
T49.5 Ophthalmological drugs and preparations
0.000 0.967 0.033
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations
0.000 0.967 0.033
T49.3 Emollients, demulcents and protectants
0.000 0.967 0.033
T49.2 Local astringents and local detergents
0.000 0.967 0.033
T49.1 Antipruritics
0.000 0.967 0.033
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified
0.000 0.967 0.033
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified
0.000 0.967 0.032
E55 Vitamin D deficiency
0.032 0.968 0.000
T46.5 Other antihypertensive drugs, not elsewhere classified
0.000 0.968 0.032
E04.9 Non-toxic goitre, unspecified
0.031 0.969 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.001 0.969 0.030
T39.0 Salicylates
0.000 0.970 0.030
T45.0 Antiallergic and antiemetic drugs
0.000 0.971 0.029
E67 Other hyperalimentation
0.028 0.971 0.000
E68 Sequelae of hyperalimentation
0.028 0.971 0.000
T38.1 Thyroid hormones and substitutes
0.000 0.971 0.028
T46.4 Angiotensin-converting-enzyme inhibitors
0.000 0.972 0.028
E61.9 Deficiency of nutrient element, unspecified
0.025 0.974 0.000
E61.8 Deficiency of other specified nutrient elements
0.025 0.974 0.000
E61.7 Deficiency of multiple nutrient elements
0.025 0.974 0.000
E61.6 Vanadium deficiency
0.025 0.974 0.000
E61.5 Molybdenum deficiency
0.025 0.974 0.000
E61.4 Chromium deficiency
0.025 0.974 0.000
E61.3 Manganese deficiency
0.025 0.974 0.000
E61.0 Copper deficiency
0.025 0.974 0.000
T45.9 Primarily systemic and haematological agent, unspecified
0.000 0.974 0.025
T45.8 Other primarily systemic and haematological agents
0.000 0.974 0.025
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.000 0.974 0.025
T45.6 Fibrinolysis-affecting drugs
0.000 0.974 0.025
T45.4 Iron and its compounds
0.000 0.974 0.025
T45.3 Enzymes, not elsewhere classified
0.000 0.974 0.025
E04.1 Non-toxic single thyroid nodule
0.025 0.975 0.000
E65 Localised adiposity
0.025 0.975 0.000
E61.2 Magnesium deficiency
0.024 0.975 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.000 0.976 0.024
K22.9 Disease of oesophagus, unspecified
0.024 0.976 0.000
E07.8 Other specified disorders of thyroid
0.023 0.976 0.000
E20-E35 Disorders of other endocrine glands
0.024 0.976 0.000
S92.3 Fracture of metatarsal bone
0.000 0.976 0.024
E55.0 Rickets, active
0.023 0.977 0.000
T45.1 Antineoplastic and immunosuppressive drugs
0.000 0.977 0.023
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified
0.001 0.977 0.022
T44.9 Other and unspecified drugs primarily affecting the nervous system
0.001 0.977 0.022
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified
0.001 0.977 0.022
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified
0.001 0.977 0.022
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified
0.001 0.977 0.022
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified
0.001 0.977 0.022
T44.2 Ganglionic blocking drugs, not elsewhere classified
0.001 0.977 0.022
T44.1 Other parasympathomimetics [cholinergics]
0.001 0.977 0.022
T44.0 Anticholinesterase agents
0.001 0.977 0.022
T45.2 Vitamins, not elsewhere classified
0.000 0.978 0.022
E26 Hyperaldosteronism
0.021 0.979 0.000
E67.8 Other specified hyperalimentation
0.021 0.979 0.000
E67.3 Hypervitaminosis D
0.021 0.979 0.000
E67.2 Megavitamin-B6 syndrome
0.021 0.979 0.000
E67.1 Hypercarotenaemia
0.021 0.979 0.000
E67.0 Hypervitaminosis A
0.021 0.979 0.000
E29 Testicular dysfunction
0.020 0.980 0.000
E26.0 Primary hyperaldosteronism
0.019 0.981 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.000 0.981 0.019
E25 Adrenogenital disorders
0.019 0.981 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.000 0.982 0.018
T43.9 Psychotropic drug, unspecified
0.000 0.982 0.018
T43.8 Other psychotropic drugs, not elsewhere classified
0.000 0.982 0.018
T43.0 Tricyclic and tetracyclic antidepressants
0.000 0.982 0.018
T43.6 Psychostimulants with abuse potential
0.000 0.982 0.017
E26.9 Hyperaldosteronism, unspecified
0.017 0.982 0.000
E29.1 Testicular hypofunction
0.017 0.983 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.017 0.983 0.000
E32 Diseases of thymus
0.017 0.983 0.000
E31 Polyglandular dysfunction
0.017 0.983 0.000
E30 Disorders of puberty, not elsewhere classified
0.017 0.983 0.000
T45.5 Anticoagulants
0.000 0.983 0.017
S92.31 Fracture of metatarsal bone (open)
0.000 0.983 0.017
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.000 0.983 0.017
E20 Hypoparathyroidism
0.017 0.983 0.000
E61.1 Iron deficiency
0.016 0.984 0.000
S92 Fracture of foot, except ankle
0.000 0.984 0.016
E26.8 Other hyperaldosteronism
0.016 0.984 0.000
E26.1 Secondary hyperaldosteronism
0.016 0.984 0.000
E22 Hyperfunction of pituitary gland
0.015 0.984 0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.015 0.985 0.000
E29.9 Testicular dysfunction, unspecified
0.014 0.985 0.000
E29.8 Other testicular dysfunction
0.014 0.985 0.000
E29.0 Testicular hyperfunction
0.014 0.985 0.000
S92.0 Fracture of calcaneus
0.000 0.986 0.014
E25.9 Adrenogenital disorder, unspecified
0.013 0.986 0.000
E25.8 Other adrenogenital disorders
0.013 0.986 0.000
E34 Other endocrine disorders
0.013 0.986 0.000
E22.1 Hyperprolactinaemia
0.013 0.987 0.000
S92.4 Fracture of great toe
0.000 0.987 0.013
E30.9 Disorder of puberty, unspecified
0.012 0.987 0.000
E30.8 Other disorders of puberty
0.012 0.987 0.000
E30.1 Precocious puberty
0.012 0.987 0.000
E30.0 Delayed puberty
0.012 0.987 0.000
E31.9 Polyglandular dysfunction, unspecified
0.012 0.987 0.000
E31.8 Other polyglandular dysfunction
0.012 0.987 0.000
E31.1 Polyglandular hyperfunction
0.012 0.987 0.000
E31.0 Autoimmune polyglandular failure
0.012 0.987 0.000
E32.9 Disease of thymus, unspecified
0.012 0.987 0.000
E32.8 Other diseases of thymus
0.012 0.987 0.000
E32.1 Abscess of thymus
0.012 0.987 0.000
E32.0 Persistent hyperplasia of thymus
0.012 0.987 0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.012 0.987 0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.012 0.987 0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.012 0.987 0.000
S92.2 Fracture of other tarsal bone(s)
0.000 0.987 0.012
S92.00 Fracture of calcaneus (closed)
0.000 0.988 0.012
E24 Cushing's syndrome
0.012 0.988 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.012 0.988 0.000
E20.8 Other hypoparathyroidism
0.012 0.988 0.000
E20.1 Pseudohypoparathyroidism
0.012 0.988 0.000
E20.0 Idiopathic hypoparathyroidism
0.012 0.988 0.000
S92.5 Fracture of other toe
0.000 0.988 0.012
S92.9 Fracture of foot, unspecified
0.000 0.988 0.012
E20.9 Hypoparathyroidism, unspecified
0.012 0.988 0.000
E23 Hypofunction and other disorders of pituitary gland
0.012 0.988 0.000
E28 Ovarian dysfunction
0.011 0.989 0.000
E22.9 Hyperfunction of pituitary gland, unspecified
0.011 0.989 0.000
E22.8 Other hyperfunction of pituitary gland
0.011 0.989 0.000
E34.0 Carcinoid syndrome
0.011 0.989 0.000
S92.1 Fracture of talus
0.000 0.989 0.011
E22.0 Acromegaly and pituitary gigantism
0.011 0.989 0.000
Z45.2 Adjustment and management of vascular access device
0.011 0.989 0.000
S92.41 Fracture of great toe (open)
0.000 0.989 0.011
S92.7 Multiple fractures of foot
0.000 0.989 0.011
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.010 0.990 0.000
S92.51 Fracture of other toe (open)
0.000 0.990 0.010
S92.01 Fracture of calcaneus (open)
0.000 0.990 0.010
E21.4 Other specified disorders of parathyroid gland
0.010 0.990 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.000 0.990 0.010
E34.5 Androgen resistance syndrome
0.010 0.990 0.000
E34.4 Constitutional tall stature
0.010 0.990 0.000
E34.3 Short stature, not elsewhere classified
0.010 0.990 0.000
E34.2 Ectopic hormone secretion, not elsewhere classified
0.010 0.990 0.000
E34.1 Other hypersecretion of intestinal hormones
0.010 0.990 0.000
S92.20 Fracture of other tarsal bone(s) (closed)
0.000 0.990 0.010
T43.2 Other and unspecified antidepressants
0.000 0.990 0.010
E27 Other disorders of adrenal gland
0.010 0.990 0.000
S92.21 Fracture of other tarsal bone(s) (open)
0.000 0.991 0.009
S92.40 Fracture of great toe (closed)
0.000 0.991 0.009
E24.8 Other Cushing's syndrome
0.009 0.991 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.009 0.991 0.000
E24.3 Ectopic ACTH syndrome
0.009 0.991 0.000
E24.1 Nelson's syndrome
0.009 0.991 0.000
E24.0 Pituitary-dependent Cushing's disease
0.009 0.991 0.000
E21.2 Other hyperparathyroidism
0.009 0.991 0.000
E55.9 Vitamin D deficiency, unspecified
0.009 0.991 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.009 0.991 0.000
S92.91 Fracture of foot, unspecified (open)
0.000 0.991 0.008
S92.90 Fracture of foot, unspecified (closed)
0.000 0.991 0.008
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.009 0.991 0.000
E23.1 Drug-induced hypopituitarism
0.009 0.991 0.000
E23.7 Disorder of pituitary gland, unspecified
0.008 0.991 0.000
E28.9 Ovarian dysfunction, unspecified
0.008 0.991 0.000
E28.8 Other ovarian dysfunction
0.008 0.991 0.000
E28.1 Androgen excess
0.008 0.991 0.000
E28.0 Oestrogen excess
0.008 0.991 0.000
E34.8 Other specified endocrine disorders
0.008 0.991 0.000
J32.0 Chronic maxillary sinusitis
0.008 0.992 0.000
S92.11 Fracture of talus (open)
0.000 0.992 0.008
E23.6 Other disorders of pituitary gland
0.008 0.992 0.000
K90.0 Coeliac disease
0.000 0.992 0.008
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified
0.003 0.992 0.005
S92.71 Multiple fractures of foot (open)
0.000 0.992 0.008
N08.3 Glomerular disorders in diabetes mellitus
0.008 0.992 0.000
E27.2 Addisonian crisis
0.008 0.992 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.008 0.992 0.000
K60.3 Anal fistula
0.000 0.992 0.008
E23.2 Diabetes insipidus
0.008 0.992 0.000
S92.10 Fracture of talus (closed)
0.000 0.992 0.008
D41.0 Kidney
0.008 0.992 0.000
S92.50 Fracture of other toe (closed)
0.000 0.992 0.007
E24.2 Drug-induced Cushing's syndrome
0.007 0.992 0.000
E28.3 Primary ovarian failure
0.007 0.993 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.007 0.993 0.000
E27.5 Adrenomedullary hyperfunction
0.007 0.993 0.000
E27.0 Other adrenocortical overactivity
0.007 0.993 0.000
S92.70 Multiple fractures of foot (closed)
0.000 0.993 0.007
H66.9 Otitis media, unspecified
0.000 0.993 0.007
Z57.2 Occupational exposure to dust
0.000 0.993 0.007
E24.9 Cushing's syndrome, unspecified
0.007 0.993 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.006 0.993 0.000
E21.3 Hyperparathyroidism, unspecified
0.007 0.993 0.000
E27.8 Other specified disorders of adrenal gland
0.006 0.993 0.000
E27.9 Disorder of adrenal gland, unspecified
0.006 0.994 0.000
K01.1 Impacted teeth
0.000 0.994 0.006
E05.5 Thyroid crisis or storm
0.006 0.994 0.000
E05.4 Thyrotoxicosis factitia
0.006 0.994 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.006 0.994 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.006 0.994 0.000
E27.1 Primary adrenocortical insufficiency
0.006 0.994 0.000
E66 Obesity
0.005 0.995 0.001
I08.0 Disorders of both mitral and aortic valves
0.000 0.995 0.005
K65.9 Peritonitis, unspecified
0.000 0.995 0.005
E34.9 Endocrine disorder, unspecified
0.004 0.995 0.001
E23.0 Hypopituitarism
0.005 0.995 0.000
M54.39 Sciatica (Site unspecified)
0.000 0.995 0.005
E05.8 Other thyrotoxicosis
0.005 0.995 0.000
E28.2 Polycystic ovarian syndrome
0.005 0.995 0.000
C67.5 Bladder neck
0.000 0.995 0.005
Z50.0 Cardiac rehabilitation
0.000 0.995 0.005
E66.1 Drug-induced obesity
0.004 0.996 0.001
K12.2 Cellulitis and abscess of mouth
0.000 0.996 0.004
D41 Neoplasm of uncertain or unknown behaviour of urinary organs
0.004 0.996 0.000
J13 Pneumonia due to Streptococcus pneumoniae
0.004 0.996 0.000
E66.0 Obesity due to excess calories
0.003 0.996 0.001
M54.36 Sciatica (Lumbar region)
0.000 0.996 0.004
M54.3 Sciatica
0.000 0.996 0.004
H00.1 Chalazion
0.004 0.996 0.000
C71.1 Frontal lobe
0.000 0.996 0.004
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.004 0.996 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.004 0.996 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.004 0.996 0.000
I49.4 Other and unspecified premature depolarisation
0.000 0.996 0.004
K65 Peritonitis
0.000 0.996 0.004
Z57 Occupational exposure to risk-factors
0.000 0.996 0.004
D41.2 Ureter
0.004 0.996 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.003 0.996 0.000
T24.3 Burn of third degree of hip and lower limb, except ankle and foot
0.004 0.996 0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.004 0.996 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.003 0.996 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.003 0.996 0.001
J42 Unspecified chronic bronchitis
0.004 0.996 0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.003 0.997 0.000
K65.0 Acute peritonitis
0.000 0.997 0.003
N43.3 Hydrocele, unspecified
0.000 0.997 0.003
T24.1 Burn of first degree of hip and lower limb, except ankle and foot
0.003 0.997 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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