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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs482759
log Bayes Factor = 26.5784
Chromosome 6   position 32,195,017  (GRCh37) Explore rs482759 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.001 0.999
G35 Multiple sclerosis
0.000 0.001 0.999
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.004 0.996
E10.1 With ketoacidosis
0.000 0.005 0.995
D50 Iron deficiency anaemia
0.000 0.012 0.988
D50.9 Iron deficiency anaemia, unspecified
0.000 0.013 0.987
D50-D53 Nutritional anaemias
0.000 0.014 0.986
L40.9 Psoriasis, unspecified
0.000 0.016 0.984
E05.9 Thyrotoxicosis, unspecified
0.000 0.022 0.978
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.024 0.976
E14 Unspecified diabetes mellitus
0.000 0.025 0.975
M06.9 Rheumatoid arthritis, unspecified
0.000 0.026 0.974
D51 Vitamin B12 deficiency anaemia
0.000 0.030 0.970
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.037 0.963
E14.9 Without complications
0.000 0.065 0.935
D50.8 Other iron deficiency anaemias
0.000 0.071 0.929
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.073 0.927
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.082 0.918
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.084 0.916
E50-E64 Other nutritional deficiencies
0.000 0.085 0.915
E14.3 With ophthalmic complications
0.000 0.091 0.909
E10.4 With neurological complications
0.000 0.104 0.896
D80-D89 Certain disorders involving the immune mechanism
0.000 0.119 0.881
D86 Sarcoidosis
0.000 0.121 0.879
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.133 0.867
D86.9 Sarcoidosis, unspecified
0.000 0.136 0.864
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.137 0.863
E10.2 With renal complications
0.000 0.139 0.861
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.141 0.859
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.151 0.849
E10.0 With coma
0.000 0.157 0.843
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.162 0.838
D68 Other coagulation defects
0.000 0.168 0.832
E10.5 With peripheral circulatory complications
0.000 0.169 0.831
E55 Vitamin D deficiency
0.000 0.170 0.830
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.171 0.829
E53 Deficiency of other B group vitamins
0.000 0.187 0.813
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.198 0.802
D86.1 Sarcoidosis of lymph nodes
0.000 0.209 0.791
D68.0 Von Willebrand's disease
0.000 0.224 0.776
D53 Other nutritional anaemias
0.000 0.225 0.775
E55.9 Vitamin D deficiency, unspecified
0.000 0.230 0.770
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.234 0.766
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.240 0.760
E16 Other disorders of pancreatic internal secretion
0.000 0.241 0.759
E06 Thyroiditis
0.000 0.245 0.755
E10.6 With other specified complications
0.000 0.252 0.748
D52 Folate deficiency anaemia
0.000 0.253 0.747
E53.8 Deficiency of other specified B group vitamins
0.000 0.278 0.722
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
D86.8 Sarcoidosis of other and combined sites
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.716
D60-D64 Aplastic and other anaemias
0.000 0.286 0.714
E14.4 With neurological complications
0.000 0.287 0.713
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.288 0.712
D50.1 Sideropenic dysphagia
0.000 0.291 0.709
E16.2 Hypoglycaemia, unspecified
0.000 0.292 0.708
E14.7 With multiple complications
0.000 0.301 0.699
E14.6 With other specified complications
0.000 0.301 0.699
E14.1 With ketoacidosis
0.000 0.301 0.699
E14.0 With coma
0.000 0.301 0.699
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.305 0.695
D51.2 Transcobalamin II deficiency
0.000 0.305 0.695
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.305 0.695
D66 Hereditary factor VIII deficiency
0.000 0.308 0.692
E14.5 With peripheral circulatory complications
0.000 0.317 0.683
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.317 0.683
D68.6 Other Thrombophilia
0.000 0.318 0.682
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.320 0.680
D86.0 Sarcoidosis of lung
0.000 0.320 0.680
E03.8 Other specified hypothyroidism
0.000 0.321 0.679
D64 Other anaemias
0.000 0.330 0.670
E05.8 Other thyrotoxicosis
0.000 0.332 0.668
E14.8 With unspecified complications
0.000 0.334 0.666
D68.8 Other specified coagulation defects
0.000 0.336 0.664
D55-D59 Haemolytic anaemias
0.000 0.338 0.662
E10.8 With unspecified complications
0.000 0.339 0.661
D68.9 Coagulation defect, unspecified
0.000 0.339 0.661
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.344 0.656
E63 Other nutritional deficiencies
0.000 0.344 0.656
E56 Other vitamin deficiencies
0.000 0.344 0.656
E50 Vitamin A deficiency
0.000 0.344 0.656
E60 Dietary zinc deficiency
0.000 0.344 0.656
E59 Dietary selenium deficiency
0.000 0.344 0.656
E54 Ascorbic acid deficiency
0.000 0.344 0.656
E52 Niacin deficiency [pellagra]
0.000 0.344 0.656
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.000 0.345 0.655
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.347 0.653
E20-E35 Disorders of other endocrine glands
0.000 0.348 0.652
E07 Other disorders of thyroid
0.000 0.351 0.649
E27 Other disorders of adrenal gland
0.000 0.351 0.649
M06 Other rheumatoid arthritis
0.000 0.351 0.649
E27.1 Primary adrenocortical insufficiency
0.000 0.356 0.644
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.364 0.636
D82 Immunodeficiency associated with other major defects
0.000 0.368 0.632
D81 Combined immunodeficiencies
0.000 0.368 0.632
E53.9 Vitamin B deficiency, unspecified
0.000 0.369 0.631
E51 Thiamine deficiency
0.000 0.370 0.630
D86.3 Sarcoidosis of skin
0.000 0.370 0.630
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.370 0.630
D64.9 Anaemia, unspecified
0.000 0.371 0.629
D53.9 Nutritional anaemia, unspecified
0.000 0.376 0.624
D67 Hereditary factor IX deficiency
0.000 0.381 0.619
E15 Nondiabetic hypoglycaemic coma
0.000 0.384 0.616
D68.1 Hereditary factor XI deficiency
0.000 0.391 0.608
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.393 0.607
R31 Unspecified haematuria
0.604 0.396 0.000
E61 Deficiency of other nutrient elements
0.000 0.397 0.603
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.400 0.600
D68.4 Acquired coagulation factor deficiency
0.000 0.403 0.597
E55.0 Rickets, active
0.000 0.404 0.595
E53.1 Pyridoxine deficiency
0.000 0.417 0.583
E53.0 Riboflavin deficiency
0.000 0.417 0.583
E04 Other non-toxic goitre
0.000 0.419 0.581
D52.9 Folate deficiency anaemia, unspecified
0.000 0.424 0.576
L40 Psoriasis
0.000 0.427 0.573
E06.9 Thyroiditis, unspecified
0.000 0.427 0.573
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.429 0.571
M06.3 Rheumatoid nodule
0.000 0.434 0.566
D61 Other aplastic anaemias
0.000 0.438 0.562
D53.8 Other specified nutritional anaemias
0.000 0.444 0.556
D53.2 Scorbutic anaemia
0.000 0.444 0.556
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.444 0.556
D53.0 Protein deficiency anaemia
0.000 0.444 0.556
E58 Dietary calcium deficiency
0.000 0.446 0.554
E27.2 Addisonian crisis
0.000 0.450 0.550
E06.3 Autoimmune thyroiditis
0.000 0.451 0.548
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.456 0.544
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.456 0.544
E16.4 Abnormal secretion of gastrin
0.000 0.456 0.544
E16.3 Increased secretion of glucagon
0.000 0.456 0.544
M06.4 Inflammatory polyarthropathy
0.000 0.456 0.544
E14.2 Withrenal complications
0.000 0.458 0.541
E06.5 Other chronic thyroiditis
0.000 0.459 0.541
E06.4 Drug-induced thyroiditis
0.000 0.459 0.541
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.459 0.541
E06.1 Subacute thyroiditis
0.000 0.459 0.541
E06.0 Acute thyroiditis
0.000 0.459 0.541
D68.5 Primary Thrombophilia
0.000 0.459 0.541
D83 Common variable immunodeficiency
0.000 0.461 0.539
G37 Other demyelinating diseases of central nervous system
0.000 0.463 0.537
D52.8 Other folate deficiency anaemias
0.000 0.464 0.535
D52.1 Drug-induced folate deficiency anaemia
0.000 0.464 0.535
D52.0 Dietary folate deficiency anaemia
0.000 0.464 0.535
D59 Acquired haemolytic anaemia
0.000 0.466 0.534
D64.8 Other specified anaemias
0.000 0.474 0.526
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.485 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
D68.2 Hereditary deficiency of other clotting factors
0.000 0.486 0.513
E40-E46 Malnutrition
0.001 0.487 0.512
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.488 0.512
E07.8 Other specified disorders of thyroid
0.000 0.494 0.506
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.499 0.501
D84 Other immunodeficiencies
0.001 0.500 0.500
E20 Hypoparathyroidism
0.000 0.502 0.497
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.508 0.492
E04.0 Non-toxic diffuse goitre
0.000 0.508 0.492
E27.9 Disorder of adrenal gland, unspecified
0.000 0.511 0.489
D56 Thalassaemia
0.000 0.516 0.484
D64.4 Congenital dyserythropoietic anaemia
0.000 0.519 0.480
D64.3 Other sideroblastic anaemias
0.000 0.519 0.480
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.519 0.480
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.519 0.480
D64.0 Hereditary sideroblastic anaemia
0.000 0.519 0.480
L40.0 Psoriasis vulgaris
0.000 0.524 0.476
E13 Other specified diabetes mellitus
0.002 0.524 0.474
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.525 0.475
D55 Anaemia due to enzyme disorders
0.000 0.525 0.475
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.528 0.472
D61.9 Aplastic anaemia, unspecified
0.000 0.530 0.470
E50.9 Vitamin A deficiency, unspecified
0.000 0.530 0.470
E50.8 Other manifestations of vitamin A deficiency
0.000 0.530 0.470
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.530 0.470
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.530 0.470
E50.5 Vitamin A deficiency with night blindness
0.000 0.530 0.470
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.530 0.470
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.530 0.470
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.530 0.470
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.530 0.470
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.530 0.470
E56.9 Vitamin deficiency, unspecified
0.000 0.530 0.470
E56.8 Deficiency of other vitamins
0.000 0.530 0.470
E56.1 Deficiency of vitamin K
0.000 0.530 0.470
E56.0 Deficiency of vitamin E
0.000 0.530 0.470
E63.9 Nutritional deficiency, unspecified
0.000 0.530 0.470
E63.8 Other specified nutritional deficiencies
0.000 0.530 0.470
E63.1 Imbalance of constituents of food intake
0.000 0.530 0.470
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.530 0.470
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.530 0.470
E64.8 Sequelae of other nutritional deficiencies
0.000 0.530 0.470
E64.3 Sequelae of rickets
0.000 0.530 0.470
E64.2 Sequelae of vitamin C deficiency
0.000 0.530 0.470
E64.1 Sequelae of vitamin A deficiency
0.000 0.530 0.470
E64.0 Sequelae of protein-energy malnutrition
0.000 0.530 0.470
G36 Other acute disseminated demyelination
0.000 0.532 0.468
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.532 0.467
E32 Diseases of thymus
0.000 0.532 0.467
E31 Polyglandular dysfunction
0.000 0.532 0.467
E30 Disorders of puberty, not elsewhere classified
0.000 0.532 0.467
E25 Adrenogenital disorders
0.000 0.532 0.467
E07.1 Dyshormogenetic goitre
0.000 0.534 0.466
E07.0 Hypersecretion of calcitonin
0.000 0.534 0.466
E27.5 Adrenomedullary hyperfunction
0.000 0.535 0.465
E27.0 Other adrenocortical overactivity
0.000 0.535 0.465
M06.2 Rheumatoid bursitis
0.000 0.535 0.465
M06.1 Adult-onset Still's disease
0.000 0.535 0.465
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.541 0.459
E27.8 Other specified disorders of adrenal gland
0.000 0.544 0.456
D81.9 Combined immunodeficiency, unspecified
0.000 0.547 0.453
D81.8 Other combined immunodeficiencies
0.000 0.547 0.453
D81.7 Major histocompatibility complex class II deficiency
0.000 0.547 0.453
D81.6 Major histocompatibility complex class I deficiency
0.000 0.547 0.453
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.547 0.453
D81.4 Nezelof's syndrome
0.000 0.547 0.453
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.547 0.453
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.547 0.453
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.547 0.453
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.547 0.453
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.547 0.453
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.547 0.453
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.547 0.453
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.547 0.453
D82.2 Immunodeficiency with short-limbed stature
0.000 0.547 0.453
D82.1 Di George's syndrome
0.000 0.547 0.453
D82.0 Wiskott-Aldrich syndrome
0.000 0.547 0.453
E51.9 Thiamine deficiency, unspecified
0.000 0.548 0.452
E51.8 Other manifestations of thiamine deficiency
0.000 0.548 0.452
E51.1 Beriberi
0.000 0.548 0.452
E65-E68 Obesity and other hyperalimentation
0.000 0.550 0.450
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.553 0.447
E70-E90 Metabolic disorders
0.000 0.554 0.446
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.556 0.444
E86 Volume depletion
0.000 0.558 0.442
E61.1 Iron deficiency
0.000 0.560 0.440
M06.8 Other specified rheumatoid arthritis
0.000 0.562 0.438
D57 Sickle-cell disorders
0.000 0.567 0.433
E61.9 Deficiency of nutrient element, unspecified
0.000 0.567 0.432
E61.8 Deficiency of other specified nutrient elements
0.000 0.567 0.432
E61.7 Deficiency of multiple nutrient elements
0.000 0.567 0.432
E61.6 Vanadium deficiency
0.000 0.567 0.432
E61.5 Molybdenum deficiency
0.000 0.567 0.432
E61.4 Chromium deficiency
0.000 0.567 0.432
E61.3 Manganese deficiency
0.000 0.567 0.432
E61.0 Copper deficiency
0.000 0.567 0.432
M06.34 Rheumatoid nodule (Hand)
0.000 0.573 0.427
D59.1 Other autoimmune haemolytic anaemias
0.000 0.573 0.427
E51.2 Wernicke's encephalopathy
0.000 0.573 0.426
D58 Other hereditary haemolytic anaemias
0.000 0.577 0.423
E04.8 Other specified non-toxic goitre
0.000 0.583 0.417
L40.1 Generalised pustular psoriasis
0.000 0.584 0.416
L40.3 Pustulosis palmaris et plantaris
0.000 0.589 0.411
L40.2 Acrodermatitis continua
0.000 0.589 0.411
L40.8 Other psoriasis
0.000 0.590 0.410
E16.1 Other hypoglycaemia
0.000 0.591 0.409
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.594 0.406
M06.38 Rheumatoid nodule (Other)
0.000 0.594 0.406
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.594 0.406
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.594 0.406
M06.33 Rheumatoid nodule (Forearm)
0.000 0.594 0.406
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.594 0.406
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.594 0.406
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.596 0.404
D61.8 Other specified aplastic anaemias
0.000 0.597 0.403
D61.3 Idiopathic aplastic anaemia
0.000 0.597 0.403
D61.2 Aplastic anaemia due to other external agents
0.000 0.597 0.403
D61.1 Drug-induced aplastic anaemia
0.000 0.598 0.402
E04.2 Non-toxic multinodular goitre
0.000 0.598 0.402
E34 Other endocrine disorders
0.000 0.602 0.398
E26 Hyperaldosteronism
0.000 0.607 0.393
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.608 0.392
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.610 0.390
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.610 0.390
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.610 0.390
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.610 0.390
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.610 0.390
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.610 0.390
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.610 0.390
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.610 0.390
E73 Lactose intolerance
0.000 0.611 0.389
E20.9 Hypoparathyroidism, unspecified
0.000 0.613 0.387
D83.8 Other common variable immunodeficiencies
0.000 0.613 0.386
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.613 0.386
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.613 0.386
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.613 0.386
G37.5 Concentric sclerosis [Balo]
0.000 0.615 0.385
G37.4 Subacute necrotising myelitis
0.000 0.615 0.385
G37.2 Central pontine myelinolysis
0.000 0.615 0.385
G37.1 Central demyelination of corpus callosum
0.000 0.615 0.385
G37.0 Diffuse sclerosis
0.000 0.615 0.385
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.616 0.384
D59.8 Other acquired haemolytic anaemias
0.000 0.617 0.383
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.617 0.383
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.617 0.383
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.617 0.383
D59.3 Haemolytic-uraemic syndrome
0.000 0.617 0.383
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.617 0.383
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.617 0.383
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.618 0.382
D61.0 Constitutional aplastic anaemia
0.000 0.623 0.376
D72 Other disorders of white blood cells
0.000 0.628 0.372
E61.2 Magnesium deficiency
0.000 0.631 0.369
E28 Ovarian dysfunction
0.000 0.632 0.368
E44 Protein-energy malnutrition of moderate and mild degree
0.001 0.632 0.367
E45 Retarded development following protein-energy malnutrition
0.001 0.632 0.367
E43 Unspecified severe protein-energy malnutrition
0.001 0.632 0.367
E42 Marasmic kwashiorkor
0.001 0.632 0.367
E41 Nutritional marasmus
0.001 0.632 0.367
E40 Kwashiorkor
0.001 0.632 0.367
D60.9 Acquired pure red cell aplasia, unspecified
0.000 0.633 0.367
D60.8 Other acquired pure red cell aplasias
0.000 0.633 0.367
D60.1 Transient acquired pure red cell aplasia
0.000 0.633 0.367
D60.0 Chronic acquired pure red cell aplasia
0.000 0.633 0.367
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.634 0.365
L40.5 Arthropathic psoriasis
0.000 0.637 0.362
E04.1 Non-toxic single thyroid nodule
0.000 0.638 0.362
D84.8 Other specified immunodeficiencies
0.001 0.641 0.358
D84.1 Defects in the complement system
0.001 0.641 0.358
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.001 0.641 0.358
E20.8 Other hypoparathyroidism
0.000 0.643 0.357
E20.1 Pseudohypoparathyroidism
0.000 0.643 0.357
E20.0 Idiopathic hypoparathyroidism
0.000 0.643 0.357
D56.3 Thalassaemia trait
0.000 0.643 0.356
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.647 0.353
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.647 0.353
D89.3 Immune reconstitution syndrome
0.000 0.647 0.353
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.647 0.353
E22 Hyperfunction of pituitary gland
0.000 0.649 0.351
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.650 0.350
E73.9 Lactose intolerance, unspecified
0.000 0.651 0.349
E24 Cushing's syndrome
0.000 0.652 0.348
D56.9 Thalassaemia, unspecified
0.000 0.653 0.347
D56.8 Other thalassaemias
0.000 0.653 0.347
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.000 0.653 0.347
D56.2 Delta-beta thalassaemia
0.000 0.653 0.347
D56.1 Beta thalassaemia
0.000 0.653 0.347
D56.0 Alpha thalassaemia
0.000 0.653 0.347
L40.4 Guttate psoriasis
0.000 0.655 0.344
D62 Acute posthaemorrhagic anaemia
0.000 0.655 0.345
E13.8 With unspecified complications
0.001 0.659 0.340
E13.7 With multiple complications
0.001 0.659 0.340
E13.6 With other specified complications
0.001 0.659 0.340
E13.5 With peripheral circulatory complications
0.001 0.659 0.340
E13.4 With neurological complications
0.001 0.659 0.340
E13.3 With ophthalmic complications
0.001 0.659 0.340
E13.2 With renal complications
0.001 0.659 0.340
E13.1 With ketoacidosis
0.001 0.659 0.340
E13.0 With coma
0.001 0.659 0.340
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.659 0.340
D55.8 Other anaemias due to enzyme disorders
0.000 0.659 0.340
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.659 0.340
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.659 0.340
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.659 0.340
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.659 0.340
G36.9 Acute disseminated demyelination, unspecified
0.000 0.664 0.336
G36.8 Other specified acute disseminated demyelination
0.000 0.664 0.336
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.664 0.336
G36.0 Neuromyelitis optica [Devic]
0.000 0.664 0.336
E25.9 Adrenogenital disorder, unspecified
0.000 0.665 0.335
E25.8 Other adrenogenital disorders
0.000 0.665 0.335
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.665 0.335
E30.9 Disorder of puberty, unspecified
0.000 0.665 0.335
E30.8 Other disorders of puberty
0.000 0.665 0.335
E30.1 Precocious puberty
0.000 0.665 0.335
E30.0 Delayed puberty
0.000 0.665 0.335
E31.9 Polyglandular dysfunction, unspecified
0.000 0.665 0.335
E31.8 Other polyglandular dysfunction
0.000 0.665 0.335
E31.1 Polyglandular hyperfunction
0.000 0.665 0.335
E31.0 Autoimmune polyglandular failure
0.000 0.665 0.335
E32.9 Disease of thymus, unspecified
0.000 0.665 0.335
E32.8 Other diseases of thymus
0.000 0.665 0.335
E32.1 Abscess of thymus
0.000 0.665 0.335
E32.0 Persistent hyperplasia of thymus
0.000 0.665 0.335
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.665 0.335
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.665 0.335
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.665 0.335
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.666 0.334
M06.18 Adult-onset Still's disease (Other)
0.000 0.666 0.334
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.666 0.334
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.666 0.334
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.666 0.334
M06.14 Adult-onset Still's disease (Hand)
0.000 0.666 0.334
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.666 0.334
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.666 0.334
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.666 0.334
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.666 0.334
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.666 0.334
M06.28 Rheumatoid bursitis (Other)
0.000 0.666 0.334
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.666 0.334
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.666 0.334
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.666 0.334
M06.24 Rheumatoid bursitis (Hand)
0.000 0.666 0.334
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.666 0.334
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.666 0.334
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.666 0.334
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.666 0.334
E29 Testicular dysfunction
0.000 0.669 0.331
D89.1 Cryoglobulinaemia
0.000 0.670 0.330
E07.9 Disorder of thyroid, unspecified
0.000 0.673 0.327
E79 Disorders of purine and pyrimidine metabolism
0.000 0.673 0.327
M06.0 Seronegative rheumatoid arthritis
0.000 0.675 0.324
E67 Other hyperalimentation
0.000 0.677 0.323
E68 Sequelae of hyperalimentation
0.000 0.677 0.323
D75 Other diseases of blood and blood-forming organs
0.000 0.677 0.323
E77 Disorders of glycoprotein metabolism
0.000 0.680 0.320
E76 Disorders of glycosaminoglycan metabolism
0.000 0.680 0.320
E72 Other disorders of amino-acid metabolism
0.000 0.680 0.320
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.680 0.320
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.680 0.320
D74 Methaemoglobinaemia
0.000 0.682 0.318
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.682 0.318
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.682 0.318
D72.8 Other specified disorders of white blood cells
0.000 0.683 0.317
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.686 0.314
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.686 0.314
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.686 0.314
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.686 0.314
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.686 0.314
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.686 0.314
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.686 0.314
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.686 0.314
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.686 0.314
D57.8 Other sickle-cell disorders
0.000 0.689 0.310
D57.3 Sickle-cell trait
0.000 0.689 0.310
D57.2 Double heterozygous sickling disorders
0.000 0.689 0.310
D57.0 Sickle-cell anaemia with crisis
0.000 0.689 0.310
E88 Other metabolic disorders
0.000 0.690 0.310
E74 Other disorders of carbohydrate metabolism
0.000 0.691 0.308
E34.0 Carcinoid syndrome
0.000 0.694 0.306
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.696 0.303
D58.2 Other haemoglobinopathies
0.000 0.696 0.303
D58.1 Hereditary elliptocytosis
0.000 0.696 0.303
E70 Disorders of aromatic amino-acid metabolism
0.000 0.699 0.300
E84 Cystic fibrosis
0.000 0.701 0.299
L40-L45 Papulosquamous disorders
0.002 0.704 0.295
D83.9 Common variable immunodeficiency, unspecified
0.001 0.707 0.293
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.710 0.290
D58.0 Hereditary spherocytosis
0.000 0.710 0.290
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.713 0.287
E22.0 Acromegaly and pituitary gigantism
0.000 0.714 0.285
E34.5 Androgen resistance syndrome
0.000 0.715 0.285
E34.4 Constitutional tall stature
0.000 0.715 0.285
E34.3 Short stature, not elsewhere classified
0.000 0.715 0.285
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.715 0.285
E34.1 Other hypersecretion of intestinal hormones
0.000 0.715 0.285
E23 Hypofunction and other disorders of pituitary gland
0.000 0.715 0.285
D76.3 Other histiocytosis syndromes
0.000 0.717 0.283
E26.9 Hyperaldosteronism, unspecified
0.000 0.718 0.282
E26.8 Other hyperaldosteronism
0.000 0.718 0.282
E26.1 Secondary hyperaldosteronism
0.000 0.718 0.282
E73.8 Other lactose intolerance
0.000 0.721 0.279
E73.1 Secondary lactase deficiency
0.000 0.721 0.279
E73.0 Congenital lactase deficiency
0.000 0.721 0.279
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.722 0.278
D72.1 Eosinophilia
0.000 0.724 0.275
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.730 0.269
D57.1 Sickle-cell anaemia without crisis
0.000 0.731 0.269
E65 Localised adiposity
0.000 0.731 0.269
D72.9 Disorder of white blood cells, unspecified
0.000 0.733 0.267
D72.0 Genetic anomalies of leukocytes
0.000 0.733 0.267
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.734 0.266
E28.9 Ovarian dysfunction, unspecified
0.000 0.736 0.264
E28.8 Other ovarian dysfunction
0.000 0.736 0.264
E28.1 Androgen excess
0.000 0.736 0.264
E28.0 Oestrogen excess
0.000 0.736 0.264

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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