TreeWAS – Variant ID: rs4959090

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E10.9 Without complications	0.000	0.000	1.000
E10 Insulin-dependent diabetes mellitus	0.000	0.000	1.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.000	1.000
E00-E07 Disorders of thyroid gland	0.000	0.000	1.000
E10-E14 Diabetes mellitus	0.000	0.000	1.000
E10.3 With ophthalmic complications	0.000	0.000	1.000
E03 Other hypothyroidism	0.000	0.003	0.997
E03.9 Hypothyroidism, unspecified	0.000	0.004	0.996
L40.9 Psoriasis, unspecified	0.000	0.004	0.996
E10.1 With ketoacidosis	0.000	0.005	0.995
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.006	0.994
D50 Iron deficiency anaemia	0.000	0.011	0.989
D50-D53 Nutritional anaemias	0.000	0.012	0.988
E27 Other disorders of adrenal gland	0.000	0.017	0.983
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.000	0.019	0.981
G35 Multiple sclerosis	0.000	0.020	0.980
E20-E35 Disorders of other endocrine glands	0.000	0.021	0.979
E27.1 Primary adrenocortical insufficiency	0.000	0.021	0.979
L40 Psoriasis	0.000	0.021	0.979
D50.9 Iron deficiency anaemia, unspecified	0.000	0.025	0.975
E05.9 Thyrotoxicosis, unspecified	0.000	0.029	0.971
D80-D89 Certain disorders involving the immune mechanism	0.000	0.031	0.969
D50.8 Other iron deficiency anaemias	0.000	0.031	0.969
D86 Sarcoidosis	0.000	0.036	0.964
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.038	0.962
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.040	0.960
E27.4 Other and unspecified adrenocortical insufficiency	0.000	0.052	0.948
D86.9 Sarcoidosis, unspecified	0.000	0.055	0.945
E16 Other disorders of pancreatic internal secretion	0.000	0.065	0.935
G35-G37 Demyelinating diseases of the central nervous system	0.000	0.069	0.931
C82.9 Follicular non-Hodgkin's lymphoma, unspecified	0.928	0.072	0.000
H36.0 Diabetic retinopathy	0.000	0.078	0.922
E16.2 Hypoglycaemia, unspecified	0.000	0.081	0.919
H36 Retinal disorders in diseases classified elsewhere	0.000	0.083	0.917
Chapter VII Diseases of the eye and adnexa	0.000	0.087	0.913
H30-H36 Disorders of choroid and retina	0.000	0.087	0.913
# Top node	0.000	0.090	0.910
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.000	0.090	0.910
E06 Thyroiditis	0.000	0.092	0.908
L40-L45 Papulosquamous disorders	0.001	0.096	0.904
D51 Vitamin B12 deficiency anaemia	0.000	0.096	0.904
Chapter VI Diseases of the nervous system	0.000	0.100	0.900
E14 Unspecified diabetes mellitus	0.000	0.103	0.897
L40.0 Psoriasis vulgaris	0.000	0.107	0.893
E50-E64 Other nutritional deficiencies	0.000	0.111	0.889
E04 Other non-toxic goitre	0.000	0.112	0.888
Chapter XII Diseases of the skin and subcutaneous tissue	0.000	0.113	0.887
H46-H48 Disorders of optic nerve and visual pathways	0.000	0.116	0.884
H02 Other disorders of eyelid	0.000	0.117	0.883
H00-H06 Disorders of eyelid, lacrimal system and orbit	0.000	0.118	0.882
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.000	0.119	0.881
C82 Follicular [nodular] non-Hodgkin's lymphoma	0.875	0.125	0.000
E27.8 Other specified disorders of adrenal gland	0.000	0.126	0.874
D86.1 Sarcoidosis of lymph nodes	0.000	0.130	0.870
H02.1 Ectropion of eyelid	0.000	0.134	0.866
H33 Retinal detachments and breaks	0.000	0.137	0.863
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.000	0.142	0.858
E10.2 With renal complications	0.000	0.143	0.857
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.000	0.144	0.856
D52 Folate deficiency anaemia	0.000	0.144	0.856
H46 Optic neuritis	0.000	0.154	0.846
H02.8 Other specified disorders of eyelid	0.000	0.156	0.844
E10.0 With coma	0.000	0.159	0.841
E06.3 Autoimmune thyroiditis	0.000	0.160	0.840
H33.3 Retinal breaks without detachment	0.000	0.169	0.831
L40.8 Other psoriasis	0.000	0.178	0.822
D68 Other coagulation defects	0.000	0.181	0.819
E14.3 With ophthalmic complications	0.000	0.182	0.818
E70-E90 Metabolic disorders	0.000	0.187	0.813
D89.2 Hypergammaglobulinaemia, unspecified	0.000	0.188	0.812
E11 Non-insulin-dependent diabetes mellitus	0.000	0.200	0.800
E86 Volume depletion	0.000	0.202	0.798
E55 Vitamin D deficiency	0.000	0.202	0.798
C82.0 Small cleaved cell, follicular	0.794	0.206	0.000
H33.4 Traction detachment of retina	0.000	0.209	0.791
C82.1 Mixed small cleaved and large cell, follicular	0.784	0.216	0.000
D86.8 Sarcoidosis of other and combined sites	0.000	0.218	0.782
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.000	0.220	0.780
E27.9 Disorder of adrenal gland, unspecified	0.000	0.222	0.778
E04.2 Non-toxic multinodular goitre	0.000	0.231	0.769
E07 Other disorders of thyroid	0.000	0.234	0.766
D52.9 Folate deficiency anaemia, unspecified	0.000	0.239	0.761
L40.5 Arthropathic psoriasis	0.000	0.240	0.760
E11.1 With ketoacidosis	0.000	0.244	0.756
H02.5 Other disorders affecting eyelid function	0.000	0.244	0.756
E53 Deficiency of other B group vitamins	0.000	0.245	0.755
D68.0 Von Willebrand's disease	0.000	0.246	0.754
E10.5 With peripheral circulatory complications	0.000	0.247	0.753
C82.3 Follicular lymphoma grade IIIa	0.748	0.252	0.000
E04.0 Non-toxic diffuse goitre	0.000	0.253	0.747
E04.9 Non-toxic goitre, unspecified	0.000	0.256	0.744
H47 Other disorders of optic [2nd] nerve and visual pathways	0.000	0.256	0.744
E10.4 With neurological complications	0.000	0.257	0.743
H20 Iridocyclitis	0.000	0.259	0.741
E27.2 Addisonian crisis	0.000	0.263	0.737
D53 Other nutritional anaemias	0.000	0.266	0.734
E55.9 Vitamin D deficiency, unspecified	0.000	0.267	0.733
L20-L30 Dermatitis and eczema	0.000	0.268	0.732
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.269	0.731
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.000	0.271	0.729
E14.9 Without complications	0.000	0.272	0.728
G90-G99 Other disorders of the nervous system	0.000	0.273	0.727
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.274	0.726
E10.6 With other specified complications	0.000	0.282	0.718
D55-D59 Haemolytic anaemias	0.000	0.283	0.717
E10.7 With multiple complications	0.000	0.283	0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.283	0.717
E00 Congenital iodine-deficiency syndrome	0.000	0.283	0.717
E12 Malnutrition-related diabetes mellitus	0.000	0.283	0.717
L10-L14 Bullous disorders	0.000	0.284	0.716
E11.3 With ophthalmic complications	0.000	0.284	0.716
E03.5 Myxoedema coma	0.000	0.285	0.715
E03.4 Atrophy of thyroid (acquired)	0.000	0.285	0.715
E03.3 Postinfectious hypothyroidism	0.000	0.285	0.715
E03.0 Congenital hypothyroidism with diffuse goitre	0.000	0.285	0.715
E88 Other metabolic disorders	0.000	0.285	0.715
E05.5 Thyroid crisis or storm	0.000	0.287	0.713
E05.4 Thyrotoxicosis factitia	0.000	0.287	0.713
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.287	0.713
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.287	0.713
E05.8 Other thyrotoxicosis	0.000	0.290	0.710
H33.2 Serous retinal detachment	0.000	0.290	0.710
D50.1 Sideropenic dysphagia	0.000	0.291	0.709
D86.0 Sarcoidosis of lung	0.000	0.292	0.708
E27.5 Adrenomedullary hyperfunction	0.000	0.295	0.705
E27.0 Other adrenocortical overactivity	0.000	0.295	0.705
E35 Disorders of endocrine glands in diseases classified elsewhere	0.000	0.298	0.702
E32 Diseases of thymus	0.000	0.298	0.702
E31 Polyglandular dysfunction	0.000	0.298	0.702
E30 Disorders of puberty, not elsewhere classified	0.000	0.298	0.702
L40.3 Pustulosis palmaris et plantaris	0.000	0.298	0.702
L40.2 Acrodermatitis continua	0.000	0.298	0.702
L40.1 Generalised pustular psoriasis	0.000	0.298	0.702
D89.9 Disorder involving the immune mechanism, unspecified	0.000	0.298	0.702
H02.2 Lagophthalmos	0.000	0.299	0.701
E22 Hyperfunction of pituitary gland	0.000	0.303	0.697
D82 Immunodeficiency associated with other major defects	0.000	0.305	0.695
D81 Combined immunodeficiencies	0.000	0.305	0.695
H20.0 Acute and subacute iridocyclitis	0.000	0.306	0.694
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction	0.000	0.307	0.693
D86.3 Sarcoidosis of skin	0.000	0.309	0.691
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.000	0.309	0.691
E15 Nondiabetic hypoglycaemic coma	0.000	0.310	0.690
E10.8 With unspecified complications	0.000	0.313	0.687
H02.9 Disorder of eyelid, unspecified	0.000	0.313	0.687
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.000	0.314	0.686
E14.1 With ketoacidosis	0.000	0.323	0.677
E03.1 Congenital hypothyroidism without goitre	0.000	0.324	0.676
E16.0 Drug-induced hypoglycaemia without coma	0.000	0.324	0.676
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.000	0.326	0.673
E16.9 Disorder of pancreatic internal secretion, unspecified	0.000	0.329	0.671
E16.8 Other specified disorders of pancreatic internal secretion	0.000	0.329	0.671
E16.4 Abnormal secretion of gastrin	0.000	0.329	0.671
E16.3 Increased secretion of glucagon	0.000	0.329	0.671
E27.3 Drug-induced adrenocortical insufficiency	0.000	0.330	0.669
C82.4 Follicular lymphoma grade IIIb	0.669	0.331	0.000
H33.1 Retinoschisis and retinal cysts	0.000	0.332	0.668
D68.8 Other specified coagulation defects	0.000	0.332	0.668
G36 Other acute disseminated demyelination	0.000	0.333	0.667
C82.7 Other types of follicular non-Hodgkin's lymphoma	0.666	0.334	0.000
E06.9 Thyroiditis, unspecified	0.000	0.338	0.662
H16 Keratitis	0.000	0.340	0.660
G30-G32 Other degenerative diseases of the nervous system	0.000	0.342	0.658
D68.5 Primary Thrombophilia	0.000	0.342	0.658
E53.8 Deficiency of other specified B group vitamins	0.000	0.342	0.658
H36.8 Other retinal disorders in diseases classified elsewhere	0.000	0.343	0.657
E85 Amyloidosis	0.000	0.343	0.657
H32 Chorioretinal disorders in diseases classified elsewhere	0.000	0.345	0.655
Chapter XVI Certain conditions originating in the perinatal period	0.000	0.347	0.652
L27 Dermatitis due to substances taken internally	0.000	0.348	0.652
E06.5 Other chronic thyroiditis	0.000	0.349	0.651
E06.4 Drug-induced thyroiditis	0.000	0.349	0.651
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.000	0.349	0.651
E06.1 Subacute thyroiditis	0.000	0.349	0.651
E06.0 Acute thyroiditis	0.000	0.349	0.651
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.000	0.349	0.651
G20-G26 Extrapyramidal and movement disorders	0.000	0.350	0.650
G93 Other disorders of brain	0.000	0.351	0.649
L40.4 Guttate psoriasis	0.000	0.351	0.648
L44 Other papulosquamous disorders	0.001	0.352	0.648
L41 Parapsoriasis	0.001	0.352	0.648
L45 Papulosquamous disorders in diseases classified elsewhere	0.001	0.352	0.648
D51.8 Other vitamin B12 deficiency anaemias	0.000	0.352	0.648
D51.3 Other dietary vitamin B12 deficiency anaemia	0.000	0.352	0.648
D51.2 Transcobalamin II deficiency	0.000	0.352	0.648
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria	0.000	0.352	0.648
E24 Cushing's syndrome	0.000	0.352	0.648
H02.0 Entropion and trichiasis of eyelid	0.000	0.353	0.647
E20 Hypoparathyroidism	0.000	0.356	0.644
E25 Adrenogenital disorders	0.000	0.356	0.644
E14.7 With multiple complications	0.000	0.357	0.643
E14.6 With other specified complications	0.000	0.357	0.643
E14.0 With coma	0.000	0.357	0.643
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.000	0.357	0.643
E07.8 Other specified disorders of thyroid	0.000	0.359	0.641
D59 Acquired haemolytic anaemia	0.000	0.359	0.641
E78.9 Disorder of lipoprotein metabolism, unspecified	0.000	0.360	0.640
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.000	0.360	0.640
E11.4 With neurological complications	0.000	0.361	0.639
E64 Sequelae of malnutrition and other nutritional deficiencies	0.000	0.363	0.637
E63 Other nutritional deficiencies	0.000	0.363	0.637
E56 Other vitamin deficiencies	0.000	0.363	0.637
E51 Thiamine deficiency	0.000	0.363	0.637
E50 Vitamin A deficiency	0.000	0.363	0.637
E60 Dietary zinc deficiency	0.000	0.363	0.637
E59 Dietary selenium deficiency	0.000	0.363	0.637
E54 Ascorbic acid deficiency	0.000	0.363	0.637
E52 Niacin deficiency [pellagra]	0.000	0.363	0.637
E04.8 Other specified non-toxic goitre	0.000	0.364	0.636
E14.8 With unspecified complications	0.000	0.364	0.636
G91 Hydrocephalus	0.000	0.364	0.636
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere	0.000	0.366	0.634
E14.2 Withrenal complications	0.000	0.367	0.633
H02.7 Other degenerative disorders of eyelid and periocular area	0.000	0.367	0.633
H30 Chorioretinal inflammation	0.000	0.368	0.632
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.000	0.368	0.632
D89.3 Immune reconstitution syndrome	0.000	0.368	0.632
D89.0 Polyclonal hypergammaglobulinaemia	0.000	0.368	0.632
C82.2 Large cell, follicular	0.631	0.369	0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere	0.000	0.369	0.631
C82.6 Cutaneous follicle centre lymphoma	0.628	0.372	0.000
C82.5 Diffuse follicle centre lymphoma	0.628	0.372	0.000
G37 Other demyelinating diseases of central nervous system	0.000	0.373	0.627
H20.9 Iridocyclitis, unspecified	0.000	0.373	0.627
E78.4 Other hyperlipidaemia	0.000	0.379	0.621
H16.0 Corneal ulcer	0.000	0.379	0.621
H02.4 Ptosis of eyelid	0.000	0.380	0.620
H02.6 Xanthelasma of eyelid	0.000	0.382	0.618
E03.8 Other specified hypothyroidism	0.000	0.382	0.618
E16.1 Other hypoglycaemia	0.000	0.384	0.616
D67 Hereditary factor IX deficiency	0.000	0.386	0.614
D52.8 Other folate deficiency anaemias	0.000	0.386	0.614
D52.1 Drug-induced folate deficiency anaemia	0.000	0.386	0.614
D52.0 Dietary folate deficiency anaemia	0.000	0.386	0.614
H49 Paralytic strabismus	0.000	0.387	0.613
H20.1 Chronic iridocyclitis	0.000	0.388	0.612
E73 Lactose intolerance	0.000	0.388	0.612
D83 Common variable immunodeficiency	0.000	0.388	0.611
H47.3 Other disorders of optic disk	0.000	0.397	0.603
E78.2 Mixed hyperlipidaemia	0.000	0.400	0.600
H19 Disorders of sclera and cornea in diseases classified elsewhere	0.000	0.402	0.598
E11.8 With unspecified complications	0.000	0.403	0.597
E11.2 With renal complications	0.000	0.403	0.597
H47.2 Optic atrophy	0.000	0.405	0.595
H10-H13 Disorders of conjunctiva	0.000	0.405	0.595
E14.4 With neurological complications	0.000	0.408	0.592
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.000	0.409	0.590
G93.9 Disorder of brain, unspecified	0.000	0.410	0.590
D68.2 Hereditary deficiency of other clotting factors	0.000	0.411	0.589
L21 Seborrhoeic dermatitis	0.000	0.412	0.588
H53-H54 Visual disturbances and blindness	0.000	0.412	0.588
G93.0 Cerebral cysts	0.000	0.413	0.587
E74 Other disorders of carbohydrate metabolism	0.000	0.414	0.586
E79 Disorders of purine and pyrimidine metabolism	0.000	0.417	0.583
E77 Disorders of glycoprotein metabolism	0.000	0.417	0.583
E76 Disorders of glycosaminoglycan metabolism	0.000	0.417	0.583
E72 Other disorders of amino-acid metabolism	0.000	0.417	0.583
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.000	0.417	0.583
E70 Disorders of aromatic amino-acid metabolism	0.000	0.417	0.583
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.000	0.417	0.583
D66 Hereditary factor VIII deficiency	0.000	0.419	0.581
H50 Other strabismus	0.000	0.419	0.581
L27.0 Generalised skin eruption due to drugs and medicaments	0.000	0.420	0.580
L42 Pityriasis rosea	0.001	0.421	0.579
G31 Other degenerative diseases of nervous system, not elsewhere classified	0.000	0.423	0.577
E40-E46 Malnutrition	0.000	0.424	0.576
E11.7 With multiple complications	0.000	0.427	0.573
L13 Other bullous disorders	0.000	0.427	0.573
E14.5 With peripheral circulatory complications	0.000	0.427	0.573
G63 Polyneuropathy in diseases classified elsewhere	0.000	0.427	0.573
E58 Dietary calcium deficiency	0.000	0.427	0.572
D59.1 Other autoimmune haemolytic anaemias	0.000	0.428	0.572
E55.0 Rickets, active	0.000	0.428	0.572
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.000	0.428	0.572
D68.4 Acquired coagulation factor deficiency	0.000	0.429	0.571
L28 Lichen simplex chronicus and prurigo	0.000	0.430	0.570
E88.2 Lipomatosis, not elsewhere classified	0.000	0.432	0.568
G91.9 Hydrocephalus, unspecified	0.000	0.432	0.568
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.000	0.433	0.567
D89.1 Cryoglobulinaemia	0.000	0.437	0.563
E61 Deficiency of other nutrient elements	0.000	0.438	0.562
D84 Other immunodeficiencies	0.000	0.439	0.561
E34 Other endocrine disorders	0.000	0.442	0.558
G25 Other extrapyramidal and movement disorders	0.000	0.442	0.558
G93.4 Encephalopathy, unspecified	0.000	0.443	0.557
D53.9 Nutritional anaemia, unspecified	0.000	0.448	0.551
G94 Other disorders of brain in diseases classified elsewhere	0.000	0.449	0.551
H03 Disorders of eyelid in diseases classified elsewhere	0.000	0.450	0.549
E07.1 Dyshormogenetic goitre	0.000	0.451	0.549
E07.0 Hypersecretion of calcitonin	0.000	0.451	0.549
E13 Other specified diabetes mellitus	0.000	0.453	0.547
H49.0 Third [oculomotor] nerve palsy	0.000	0.453	0.546
E84 Cystic fibrosis	0.000	0.455	0.545
L23 Allergic contact dermatitis	0.000	0.456	0.544
G99 Other disorders of nervous system in diseases classified elsewhere	0.000	0.457	0.543
H47.1 Papilloedema, unspecified	0.000	0.457	0.543
E53.9 Vitamin B deficiency, unspecified	0.000	0.457	0.543
L11 Other acantholytic disorders	0.000	0.458	0.542
E53.1 Pyridoxine deficiency	0.000	0.459	0.541
E53.0 Riboflavin deficiency	0.000	0.459	0.541
E28 Ovarian dysfunction	0.000	0.459	0.541
E78.8 Other disorders of lipoprotein metabolism	0.000	0.459	0.541
D68.1 Hereditary factor XI deficiency	0.000	0.459	0.540
H15 Disorders of sclera	0.000	0.461	0.539
H34 Retinal vascular occlusions	0.000	0.462	0.538
H05 Disorders of orbit	0.000	0.466	0.534
L25 Unspecified contact dermatitis	0.000	0.466	0.533
H47.7 Disorder of visual pathways, unspecified	0.000	0.467	0.533
H47.6 Disorders of visual cortex	0.000	0.467	0.533
H47.5 Disorders of other visual pathways	0.000	0.467	0.533
H47.4 Disorders of optic chiasm	0.000	0.467	0.533
E85.9 Amyloidosis, unspecified	0.000	0.468	0.532
H00 Hordeolum and chalazion	0.000	0.469	0.531
H20.2 Lens-induced iridocyclitis	0.000	0.469	0.531
G93.5 Compression of brain	0.000	0.472	0.528
D68.6 Other Thrombophilia	0.000	0.474	0.526
D53.8 Other specified nutritional anaemias	0.000	0.474	0.526
D53.2 Scorbutic anaemia	0.000	0.474	0.526
D53.1 Other megaloblastic anaemias, not elsewhere classified	0.000	0.474	0.526
D53.0 Protein deficiency anaemia	0.000	0.474	0.526
L24 Irritant contact dermatitis	0.000	0.475	0.525
L26 Exfoliative dermatitis	0.000	0.475	0.525
L22 Diaper [napkin] dermatitis	0.000	0.475	0.525
G63.2 Diabetic polyneuropathy	0.000	0.477	0.523
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system	0.000	0.477	0.523
E29 Testicular dysfunction	0.000	0.477	0.522
H50.5 Heterophoria	0.000	0.478	0.522
G98 Other disorders of nervous system, not elsewhere classified	0.000	0.479	0.521
G92 Toxic encephalopathy	0.000	0.479	0.521
Chapter XXII Codes for special purposes	0.000	0.480	0.520
H47.0 Disorders of optic nerve, not elsewhere classified	0.000	0.480	0.520
E88.8 Other specified metabolic disorders	0.000	0.482	0.518
E65-E68 Obesity and other hyperalimentation	0.000	0.482	0.518
E85.4 Organ-limited amyloidosis	0.000	0.482	0.518
L20 Atopic dermatitis	0.000	0.485	0.515
D55 Anaemia due to enzyme disorders	0.000	0.485	0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.000	0.486	0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.000	0.486	0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.000	0.486	0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.000	0.486	0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.486	0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.000	0.486	0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.000	0.486	0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.000	0.486	0.514
E12.9 Without complications	0.000	0.486	0.514
E12.8 With unspecified complications	0.000	0.486	0.514
E12.7 With multiple complications	0.000	0.486	0.514
E12.6 With other specified complications	0.000	0.486	0.514
E12.5 With peripheral circulatory complications	0.000	0.486	0.514
E12.4 With neurological complications	0.000	0.486	0.514
E12.3 With ophthalmic complications	0.000	0.486	0.514
E12.2 With renal complications	0.000	0.486	0.514
E12.1 With ketoacidosis	0.000	0.486	0.514
E12.0 With coma	0.000	0.486	0.514
L10 Pemphigus	0.000	0.487	0.513
L14 Bullous disorders in diseases classified elsewhere	0.000	0.487	0.513
L12 Pemphigoid	0.000	0.487	0.513
E88.1 Lipodystrophy, not elsewhere classified	0.000	0.487	0.512
E26 Hyperaldosteronism	0.001	0.489	0.510
H49.1 Fourth [trochlear] nerve palsy	0.000	0.491	0.509
E22.0 Acromegaly and pituitary gigantism	0.000	0.491	0.508
E88.3 Tumour lysis syndrome	0.000	0.492	0.508
H01 Other inflammation of eyelid	0.000	0.495	0.505
G31.8 Other specified degenerative diseases of nervous system	0.000	0.496	0.504
E30.9 Disorder of puberty, unspecified	0.000	0.496	0.503
E30.8 Other disorders of puberty	0.000	0.496	0.503
E30.1 Precocious puberty	0.000	0.496	0.503
E30.0 Delayed puberty	0.000	0.496	0.503
E31.9 Polyglandular dysfunction, unspecified	0.000	0.496	0.503
E31.8 Other polyglandular dysfunction	0.000	0.496	0.503
E31.1 Polyglandular hyperfunction	0.000	0.496	0.503
E31.0 Autoimmune polyglandular failure	0.000	0.496	0.503
E32.9 Disease of thymus, unspecified	0.000	0.496	0.503
E32.8 Other diseases of thymus	0.000	0.496	0.503
E32.1 Abscess of thymus	0.000	0.496	0.503
E32.0 Persistent hyperplasia of thymus	0.000	0.496	0.503
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.000	0.496	0.503
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.000	0.496	0.503
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.000	0.496	0.503
E22.9 Hyperfunction of pituitary gland, unspecified	0.000	0.500	0.500
E22.8 Other hyperfunction of pituitary gland	0.000	0.500	0.500
D81.9 Combined immunodeficiency, unspecified	0.000	0.502	0.498
D81.8 Other combined immunodeficiencies	0.000	0.502	0.498
D81.7 Major histocompatibility complex class II deficiency	0.000	0.502	0.498
D81.6 Major histocompatibility complex class I deficiency	0.000	0.502	0.498
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.000	0.502	0.498
D81.4 Nezelof's syndrome	0.000	0.502	0.498
D81.3 Adenosine deaminase [ADA] deficiency	0.000	0.502	0.498
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.000	0.502	0.498
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.000	0.502	0.498
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.000	0.502	0.498
D82.9 Immunodeficiency associated with major defect, unspecified	0.000	0.502	0.498
D82.8 Immunodeficiency associated with other specified major defects	0.000	0.502	0.498
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.000	0.502	0.498
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.000	0.502	0.498
D82.2 Immunodeficiency with short-limbed stature	0.000	0.502	0.498
D82.1 Di George's syndrome	0.000	0.502	0.498
D82.0 Wiskott-Aldrich syndrome	0.000	0.502	0.498
G25.0 Essential tremor	0.000	0.502	0.498
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.000	0.503	0.497
G91.0 Communicating hydrocephalus	0.000	0.504	0.496
D59.9 Acquired haemolytic anaemia, unspecified	0.000	0.505	0.495
D56 Thalassaemia	0.000	0.506	0.494
H22 Disorders of iris and ciliary body in diseases classified elsewhere	0.000	0.506	0.493
H51 Other disorders of binocular movement	0.000	0.507	0.492
E78.6 Lipoprotein deficiency	0.000	0.508	0.492
E78.3 Hyperchylomicronaemia	0.000	0.508	0.492
L27.1 Localised skin eruption due to drugs and medicaments	0.000	0.508	0.492
G91.8 Other hydrocephalus	0.000	0.509	0.490
G11 Hereditary ataxia	0.000	0.509	0.490
L50-L54 Urticaria and erythema	0.000	0.511	0.489
G90 Disorders of autonomic nervous system	0.000	0.513	0.487
L21.9 Seborrhoeic dermatitis, unspecified	0.000	0.515	0.485
E24.0 Pituitary-dependent Cushing's disease	0.000	0.516	0.484
L27.2 Dermatitis due to ingested food	0.000	0.519	0.481
D68.9 Coagulation defect, unspecified	0.000	0.520	0.480
G36.9 Acute disseminated demyelination, unspecified	0.000	0.521	0.478
G36.8 Other specified acute disseminated demyelination	0.000	0.521	0.478
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]	0.000	0.521	0.478
G36.0 Neuromyelitis optica [Devic]	0.000	0.521	0.478
E11.0 With coma	0.000	0.526	0.474
E07.9 Disorder of thyroid, unspecified	0.000	0.526	0.474
H16.8 Other keratitis	0.000	0.527	0.473
H16.4 Corneal neovascularisation	0.000	0.527	0.473
H16.3 Interstitial and deep keratitis	0.000	0.527	0.473
G32 Other degenerative disorders of nervous system in diseases classified elsewhere	0.000	0.528	0.472
E85.8 Other amyloidosis	0.000	0.529	0.471
E85.2 Heredofamilial amyloidosis, unspecified	0.000	0.529	0.471
E85.1 Neuropathic heredofamilial amyloidosis	0.000	0.529	0.471
E85.0 Nonneuropathic heredofamilial amyloidosis	0.000	0.529	0.471
L13.0 Dermatitis herpetiformis	0.000	0.529	0.471
H32.8 Other chorioretinal disorders in diseases classified elsewhere	0.000	0.530	0.469
H32.0 Chorioretinal inflammation in infectious and parasitic diseases classified elsewhere	0.000	0.530	0.469
G31.2 Degeneration of nervous system due to alcohol	0.000	0.530	0.470
D57 Sickle-cell disorders	0.000	0.531	0.469
P90-P96 Other disorders originating in the perinatal period	0.000	0.532	0.468
P80-P83 Conditions involving the integument and temperature regulation of fetus and newborn	0.000	0.532	0.468
P75-P78 Digestive system disorders of fetus and newborn	0.000	0.532	0.468
P70-P74 Transitory endocrine and metabolic disorders specific to fetus and newborn	0.000	0.532	0.468
P50-P61 Haemorrhagic and haematological disorders of fetus and newborn	0.000	0.532	0.468
P35-P39 Infections specific to the perinatal period	0.000	0.532	0.468
P20-P29 Respiratory and cardiovascular disorders specific to the perinatal period	0.000	0.532	0.468
P10-P15 Birth trauma	0.000	0.532	0.468
P05-P08 Disorders related to length of gestation and fetal growth	0.000	0.532	0.468
P00-P04 Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery	0.000	0.532	0.468
L27.9 Dermatitis due to unspecified substance taken internally	0.000	0.533	0.467
L27.8 Dermatitis due to other substances taken internally	0.000	0.533	0.467
E73.9 Lactose intolerance, unspecified	0.000	0.533	0.467
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere	0.000	0.533	0.467
G10 Huntington's disease	0.000	0.533	0.467
H17 Corneal scars and opacities	0.000	0.533	0.466
G23 Other degenerative diseases of basal ganglia	0.000	0.534	0.466
G21 Secondary Parkinsonism	0.000	0.534	0.466
G26 Extrapyramidal and movement disorders in diseases classified elsewhere	0.000	0.534	0.466
G22 Parkinsonism in diseases classified elsewhere	0.000	0.534	0.466
G93.7 Reye's syndrome	0.000	0.535	0.465
L41.9 Parapsoriasis, unspecified	0.001	0.535	0.464
L41.8 Other parapsoriasis	0.001	0.535	0.464
L41.5 Retiform parapsoriasis	0.001	0.535	0.464
L41.4 Large plaque parapsoriasis	0.001	0.535	0.464
L41.3 Small plaque parapsoriasis	0.001	0.535	0.464
L41.2 Lymphomatoid papulosis	0.001	0.535	0.464
L41.1 Pityriasis lichenoides chronica	0.001	0.535	0.464
L41.0 Pityriasis lichenoides et varioliformis acuta	0.001	0.535	0.464
L44.9 Papulosquamous disorder, unspecified	0.001	0.535	0.464
L44.8 Other specified papulosquamous disorders	0.001	0.535	0.464
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]	0.001	0.535	0.464
L44.3 Lichen ruber moniliformis	0.001	0.535	0.464
L44.2 Lichen striatus	0.001	0.535	0.464
L44.1 Lichen nitidus	0.001	0.535	0.464
L44.0 Pityriasis rubra pilaris	0.001	0.535	0.464
E24.8 Other Cushing's syndrome	0.000	0.535	0.464
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.000	0.535	0.464
E24.3 Ectopic ACTH syndrome	0.000	0.535	0.464
E24.2 Drug-induced Cushing's syndrome	0.000	0.535	0.464
E24.1 Nelson's syndrome	0.000	0.535	0.464
G93.1 Anoxic brain damage, not elsewhere classified	0.000	0.537	0.463
H31 Other disorders of choroid	0.000	0.538	0.462
E20.8 Other hypoparathyroidism	0.000	0.538	0.462
E20.1 Pseudohypoparathyroidism	0.000	0.538	0.462
E20.0 Idiopathic hypoparathyroidism	0.000	0.538	0.462
E25.9 Adrenogenital disorder, unspecified	0.000	0.538	0.462
E25.8 Other adrenogenital disorders	0.000	0.538	0.462
G64 Other disorders of peripheral nervous system	0.000	0.539	0.461
H19.3 Keratitis and keratoconjunctivitis in other diseases classified elsewhere	0.000	0.539	0.460
G12 Spinal muscular atrophy and related syndromes	0.000	0.540	0.460
D59.8 Other acquired haemolytic anaemias	0.000	0.540	0.459
D59.6 Haemoglobinuria due to haemolysis from other external causes	0.000	0.540	0.459
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]	0.000	0.540	0.459
D59.4 Other nonautoimmune haemolytic anaemias	0.000	0.540	0.459
D59.3 Haemolytic-uraemic syndrome	0.000	0.540	0.459
D59.2 Drug-induced nonautoimmune haemolytic anaemia	0.000	0.540	0.459
D59.0 Drug-induced autoimmune haemolytic anaemia	0.000	0.540	0.459
H49.9 Paralytic strabismus, unspecified	0.000	0.541	0.459
G97 Postprocedural disorders of nervous system, not elsewhere classified	0.000	0.541	0.458
E50.9 Vitamin A deficiency, unspecified	0.000	0.543	0.457
E50.8 Other manifestations of vitamin A deficiency	0.000	0.543	0.457
E50.7 Other ocular manifestations of vitamin A deficiency	0.000	0.543	0.457
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.000	0.543	0.457
E50.5 Vitamin A deficiency with night blindness	0.000	0.543	0.457

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations